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Aliases for KLHL32 Gene

Aliases for KLHL32 Gene

  • Kelch Like Family Member 32 2 3 5
  • KIAA1900 2 3 4
  • BTB And Kelch Domain Containing 5 2 3
  • BKLHD5 3 4
  • BTB And Kelch Domain-Containing Protein 5 4
  • Kelch-Like 32 (Drosophila) 2
  • Kelch-Like Protein 32 3
  • UG0030H05 3
  • DJ21F7.1 3

External Ids for KLHL32 Gene

Previous HGNC Symbols for KLHL32 Gene

  • BKLHD5
  • KIAA1900

Previous GeneCards Identifiers for KLHL32 Gene

  • GC06P097480
  • GC06P097372
  • GC06P094806

Summaries for KLHL32 Gene

GeneCards Summary for KLHL32 Gene

KLHL32 (Kelch Like Family Member 32) is a Protein Coding gene. An important paralog of this gene is KLHL9.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL32 Gene

Genomics for KLHL32 Gene

Regulatory Elements for KLHL32 Gene

Enhancers for KLHL32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G096923 1.3 ENCODE dbSUPER 6.9 +26.4 26446 2.1 HDGF ARNT FEZF1 DMAP1 ZNF2 ZNF766 ZNF416 ZNF263 SP3 MXD4 KLHL32 RN7SL509P LOC101927314
GH06G096810 0.9 dbSUPER 9.7 -85.5 -85495 3.2 ZNF493 ZFP64 ZNF155 ZNF121 ZNF138 ZNF366 ZNF354C KLF7 ZNF202 ZNF654 GPR63 NDUFAF4 KLHL32 PIR60553
GH06G096965 0.5 dbSUPER 15.4 +68.7 68666 1.5 GATA3 ZNF133 FOXA1 KLHL32 GPR63 NDUFAF4 RN7SL509P LOC101927314
GH06G097023 0.6 dbSUPER 11 +129.1 129059 7.8 CTCF RFX1 JUNB EP300 SMARCA4 CREB1 WT1 ZBTB17 KLHL32 NDUFAF4 RN7SL509P LOC101927314
GH06G096967 0.4 dbSUPER 15.1 +71.2 71196 3.1 CREB1 CEBPB KLHL32 GPR63 RN7SL509P LOC101927314
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL32 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000200143 -113 2201 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for KLHL32 Gene

Chromosome:
6
Start:
96,898,013 bp from pter
End:
97,142,614 bp from pter
Size:
244,602 bases
Orientation:
Plus strand

Genomic View for KLHL32 Gene

Genes around KLHL32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL32 Gene

Proteins for KLHL32 Gene

  • Protein details for KLHL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NJ5-KLH32_HUMAN
    Recommended name:
    Kelch-like protein 32
    Protein Accession:
    Q96NJ5
    Secondary Accessions:
    • B7Z346
    • B7Z4E2
    • E1P528
    • Q5THT0
    • Q96PY7

    Protein attributes for KLHL32 Gene

    Size:
    620 amino acids
    Molecular mass:
    70362 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLHL32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL32 Gene

Post-translational modifications for KLHL32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLHL32 Gene

Domains & Families for KLHL32 Gene

No data available for UniProtKB/Swiss-Prot for KLHL32 Gene

Function for KLHL32 Gene

Gene Ontology (GO) - Molecular Function for KLHL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with KLHL32: view
genes like me logo Genes that share phenotypes with KLHL32: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL32 Gene

Localization for KLHL32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL32 gene
Compartment Confidence
nucleus 2
cytosol 2

Gene Ontology (GO) - Cellular Components for KLHL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL32 Gene

Pathways & Interactions for KLHL32 Gene

SuperPathways for KLHL32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IBA --
GO:0008584 male gonad development IBA --
GO:0009566 fertilization IBA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL32: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL32 Gene

Drugs & Compounds for KLHL32 Gene

No Compound Related Data Available

Transcripts for KLHL32 Gene

Unigene Clusters for KLHL32 Gene

Kelch-like family member 32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL32 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - -
SP5:
SP6: -

Relevant External Links for KLHL32 Gene

GeneLoc Exon Structure for
KLHL32
ECgene alternative splicing isoforms for
KLHL32

Expression for KLHL32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL32 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.5), Brain - Hippocampus (x5.3), Brain - Substantia nigra (x5.1), Brain - Hypothalamus (x4.2), and Brain - Amygdala (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of KLHL32 Gene:

KLHL32

SOURCE GeneReport for Unigene cluster for KLHL32 Gene:

Hs.45056

Evidence on tissue expression from TISSUES for KLHL32 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with KLHL32: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL32 Gene

Orthologs for KLHL32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL32 34 35
  • 99.52 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL32 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL32 34 35
  • 93.49 (n)
cow
(Bos Taurus)
Mammalia KLHL32 34 35
  • 92.8 (n)
rat
(Rattus norvegicus)
Mammalia Klhl32 34
  • 91.61 (n)
mouse
(Mus musculus)
Mammalia Klhl32 34 16 35
  • 91.34 (n)
chicken
(Gallus gallus)
Aves KLHL32 34 35
  • 82.9 (n)
lizard
(Anolis carolinensis)
Reptilia KLHL32 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14602 34
zebrafish
(Danio rerio)
Actinopterygii klhl32 34 35
  • 72.31 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.449 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
Species where no ortholog for KLHL32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL32 Gene

ENSEMBL:
Gene Tree for KLHL32 (if available)
TreeFam:
Gene Tree for KLHL32 (if available)

Paralogs for KLHL32 Gene

genes like me logo Genes that share paralogs with KLHL32: view

Variants for KLHL32 Gene

Sequence variations from dbSNP and Humsavar for KLHL32 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs63751061 Pathogenic 96,896,790(-) GTTTC(C/T)AAAAG upstream-variant-2KB, reference, missense
rs755636317 Likely benign 96,896,746(+) TACCT(A/G/T)CAAGG upstream-variant-2KB, reference, stop-gained
rs372635399 Uncertain significance 96,897,850(+) ACACC(A/C/G/T)GCGCA upstream-variant-2KB, utr-variant-5-prime
rs749427985 Uncertain significance 96,897,841(+) CACGT(A/C/G)GGAAC upstream-variant-2KB, utr-variant-5-prime
rs78567928 Uncertain significance 96,896,800(+) CGACA(A/G)CAGCT upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KLHL32 Gene

Variant ID Type Subtype PubMed ID
esv1215963 CNV insertion 17803354
esv2370829 CNV deletion 18987734
esv2396648 CNV deletion 18987734
esv2604268 CNV deletion 19546169
esv2656950 CNV deletion 23128226
esv2661411 CNV deletion 23128226
esv2676410 CNV deletion 23128226
esv2732463 CNV deletion 23290073
esv2732464 CNV deletion 23290073
esv27575 CNV loss 19812545
esv3540181 CNV deletion 23714750
esv3540182 CNV deletion 23714750
esv3571308 CNV loss 25503493
esv3610082 CNV loss 21293372
esv8405 CNV loss 19470904
nsv436524 CNV deletion 17901297
nsv472682 CNV novel sequence insertion 20440878
nsv474329 CNV novel sequence insertion 20440878
nsv524695 CNV loss 19592680
nsv5402 CNV insertion 18451855
nsv956549 CNV deletion 24416366

Variation tolerance for KLHL32 Gene

Residual Variation Intolerance Score: 14.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.71; 66.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL32 Gene

Disorders for KLHL32 Gene

Relevant External Links for KLHL32

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL32

No disorders were found for KLHL32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL32 Gene

Publications for KLHL32 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia. (PMID: 24954895) Simino J. … Rao D.C. (Am. J. Hum. Genet. 2014) 3 64
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3 64

Products for KLHL32 Gene

Sources for KLHL32 Gene

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