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Aliases for KLHL31 Gene

Aliases for KLHL31 Gene

  • Kelch-Like Family Member 31 2 3
  • KLHL 3 4 6
  • Kelch Repeat And BTB Domain-Containing Protein 1 3 4
  • Kelch Repeat And BTB (POZ) Domain Containing 1 2 3
  • BTB And Kelch Domain-Containing Protein 6 3 4
  • Kelch-Like Protein KLHL 3 4
  • KBTBD1 3 4
  • BKLHD6 3 4
  • Kelch-Like 31 (Drosophila) 2
  • Kelch-Like Protein 31 3
  • BA345L23.2 3

External Ids for KLHL31 Gene

Previous HGNC Symbols for KLHL31 Gene

  • KBTBD1

Previous GeneCards Identifiers for KLHL31 Gene

  • GC06M053513
  • GC06M053344

Summaries for KLHL31 Gene

GeneCards Summary for KLHL31 Gene

KLHL31 (Kelch-Like Family Member 31) is a Protein Coding gene. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL31 Gene

  • Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL31 Gene

Genomics for KLHL31 Gene

Regulatory Elements for KLHL31 Gene

Genomic Location for KLHL31 Gene

53,647,901 bp from pter
53,665,708 bp from pter
17,808 bases
Minus strand

Genomic View for KLHL31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL31 Gene

Proteins for KLHL31 Gene

  • Protein details for KLHL31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 31
    Protein Accession:
    Secondary Accessions:
    • A6N9J2
    • B2RP49

    Protein attributes for KLHL31 Gene

    634 amino acids
    Molecular mass:
    70246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL31 Gene

Proteomics data for KLHL31 Gene at MOPED

Post-translational modifications for KLHL31 Gene

Other Protein References for KLHL31 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL31 Gene

Domains for KLHL31 Gene

Gene Families for KLHL31 Gene

  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H511
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL31: view

Function for KLHL31 Gene

Molecular function for KLHL31 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Gene Ontology (GO) - Molecular Function for KLHL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL31: view

Phenotypes for KLHL31 Gene

GenomeRNAi human phenotypes for KLHL31:
genes like me logo Genes that share phenotypes with KLHL31: view

Animal Model Products

CRISPR Products

miRNA for KLHL31 Gene

miRTarBase miRNAs that target KLHL31

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL31

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL31 Gene

Localization for KLHL31 Gene

Subcellular locations from

Jensen Localization Image for KLHL31 Gene COMPARTMENTS Subcellular localization image for KLHL31 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL31 Gene

Pathways for KLHL31 Gene

SuperPathways for KLHL31 Gene

No Data Available

Interacting Proteins for KLHL31 Gene

Gene Ontology (GO) - Biological Process for KLHL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with KLHL31: view

No data available for Pathways by source for KLHL31 Gene

Transcripts for KLHL31 Gene

mRNA/cDNA for KLHL31 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL31 Gene

Kelch-like family member 31:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL31

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KLHL31

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL31 Gene

No ASD Table

Relevant External Links for KLHL31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL31 Gene

mRNA expression in normal human tissues for KLHL31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL31 Gene

This gene is overexpressed in Heart - Left Ventricle (23.1), Heart - Atrial Appendage (13.2), and Muscle - Skeletal (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLHL31 Gene

SOURCE GeneReport for Unigene cluster for KLHL31 Gene Hs.131064

mRNA Expression by UniProt/SwissProt for KLHL31 Gene

Tissue specificity: Strongly expressed in skeletal muscle and weakly in heart. According to PubMed:15302408, not expressed in other tissues. According to PubMed:18719355, abundantly expressed in both embryonic skeletal and heart tissues.
genes like me logo Genes that share expressions with KLHL31: view

In Situ Assay Products

Orthologs for KLHL31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL31 35
  • 99.26 (n)
  • 99.05 (a)
KLHL31 36
  • 99 (a)
(Bos Taurus)
Mammalia KLHL31 36
  • 92 (a)
(Canis familiaris)
Mammalia KLHL31 35
  • 91.13 (n)
  • 92.63 (a)
KLHL31 36
  • 93 (a)
(Mus musculus)
Mammalia Klhl31 35
  • 87.13 (n)
  • 91.99 (a)
Klhl31 16
Klhl31 36
  • 92 (a)
(Monodelphis domestica)
Mammalia KLHL31 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
-- 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Klhl31 35
  • 87.34 (n)
  • 91.35 (a)
(Gallus gallus)
Aves KLHL31 35
  • 77.07 (n)
  • 84.15 (a)
KLHL31 36
  • 84 (a)
(Anolis carolinensis)
Reptilia KLHL31 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl31 35
  • 73.93 (n)
  • 80.77 (a)
(Danio rerio)
Actinopterygii klhl31 35
  • 69.82 (n)
  • 75.48 (a)
klhl31 36
  • 76 (a)
Species with no ortholog for KLHL31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL31 Gene

Gene Tree for KLHL31 (if available)
Gene Tree for KLHL31 (if available)

Paralogs for KLHL31 Gene

Selected SIMAP similar genes for KLHL31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHL31: view

Variants for KLHL31 Gene

Sequence variations from dbSNP and Humsavar for KLHL31 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs997604 -- 53,649,264(+) CTCGC(C/T)AATGT utr-variant-3-prime
rs1326546 -- 53,653,833(+) TCTCT(A/G)GGTAT intron-variant
rs1326548 -- 53,658,121(+) GGGCA(G/T)CCCAG intron-variant
rs1326549 -- 53,658,208(+) AGGAG(C/G)TAGGT intron-variant
rs1326550 -- 53,658,311(+) GCTTG(C/T)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL31 Gene

Variant ID Type Subtype PubMed ID
nsv519037 CNV Loss 19592680
esv2732097 CNV Deletion 23290073

Relevant External Links for KLHL31 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL31 Gene

Disorders for KLHL31 Gene

Relevant External Links for KLHL31

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with KLHL31: view

No data available for UniProtKB/Swiss-Prot for KLHL31 Gene

Publications for KLHL31 Gene

  1. A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. (PMID: 15302408) Wu Y.L. … Gong Z. (Gene 2004) 3 4 23
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE. (PMID: 18719355) Yu W. … Wu X. (Mol. Cells 2008) 3 4
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3

Products for KLHL31 Gene

Sources for KLHL31 Gene

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