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Aliases for KLHL31 Gene

Aliases for KLHL31 Gene

  • Kelch Like Family Member 31 2 3 5
  • Kelch Repeat And BTB Domain-Containing Protein 1 3 4
  • Kelch Repeat And BTB (POZ) Domain Containing 1 2 3
  • BTB And Kelch Domain-Containing Protein 6 3 4
  • Kelch-Like Protein KLHL 3 4
  • KBTBD1 3 4
  • BKLHD6 3 4
  • KLHL 3 4
  • Kelch-Like Family Member 31 3
  • Kelch-Like 31 (Drosophila) 2
  • BA345L23.2 3

External Ids for KLHL31 Gene

Previous HGNC Symbols for KLHL31 Gene

  • KBTBD1

Previous GeneCards Identifiers for KLHL31 Gene

  • GC06M053513
  • GC06M053344

Summaries for KLHL31 Gene

GeneCards Summary for KLHL31 Gene

KLHL31 (Kelch Like Family Member 31) is a Protein Coding gene. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL31 Gene

  • Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL31 Gene

Genomics for KLHL31 Gene

Regulatory Elements for KLHL31 Gene

Promoters for KLHL31 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL31 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL31 Gene

Chromosome:
6
Start:
53,647,901 bp from pter
End:
53,665,846 bp from pter
Size:
17,946 bases
Orientation:
Minus strand

Genomic View for KLHL31 Gene

Genes around KLHL31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL31 Gene

Proteins for KLHL31 Gene

  • Protein details for KLHL31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H511-KLH31_HUMAN
    Recommended name:
    Kelch-like protein 31
    Protein Accession:
    Q9H511
    Secondary Accessions:
    • A6N9J2
    • B2RP49

    Protein attributes for KLHL31 Gene

    Size:
    634 amino acids
    Molecular mass:
    70246 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL31 Gene

Proteomics data for KLHL31 Gene at MOPED

Post-translational modifications for KLHL31 Gene

Other Protein References for KLHL31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KLHL31 Gene

Domains & Families for KLHL31 Gene

Gene Families for KLHL31 Gene

Suggested Antigen Peptide Sequences for KLHL31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H511

UniProtKB/Swiss-Prot:

KLH31_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL31: view

Function for KLHL31 Gene

Molecular function for KLHL31 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Gene Ontology (GO) - Molecular Function for KLHL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL31: view
genes like me logo Genes that share phenotypes with KLHL31: view

Animal Model Products

miRNA for KLHL31 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL31 Gene

Localization for KLHL31 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL31 Gene COMPARTMENTS Subcellular localization image for KLHL31 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL31 Gene

Pathways & Interactions for KLHL31 Gene

SuperPathways for KLHL31 Gene

No Data Available

Interacting Proteins for KLHL31 Gene

Gene Ontology (GO) - Biological Process for KLHL31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with KLHL31: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL31 Gene

Drugs & Compounds for KLHL31 Gene

No Compound Related Data Available

Transcripts for KLHL31 Gene

mRNA/cDNA for KLHL31 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL31 Gene

Kelch-like family member 31:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL31 Gene

No ASD Table

Relevant External Links for KLHL31 Gene

GeneLoc Exon Structure for
KLHL31
ECgene alternative splicing isoforms for
KLHL31

Expression for KLHL31 Gene

mRNA expression in normal human tissues for KLHL31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL31 Gene

This gene is overexpressed in Heart - Left Ventricle (x23.1), Heart - Atrial Appendage (x13.2), and Muscle - Skeletal (x9.4).

Protein differential expression in normal tissues from HIPED for KLHL31 Gene

This gene is overexpressed in Heart (55.8) and Fetal heart (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL31 Gene



SOURCE GeneReport for Unigene cluster for KLHL31 Gene Hs.131064

mRNA Expression by UniProt/SwissProt for KLHL31 Gene

Q9H511-KLH31_HUMAN
Tissue specificity: Strongly expressed in skeletal muscle and weakly in heart. According to PubMed:15302408, not expressed in other tissues. According to PubMed:18719355, abundantly expressed in both embryonic skeletal and heart tissues.
genes like me logo Genes that share expression patterns with KLHL31: view

Protein tissue co-expression partners for KLHL31 Gene

Primer Products

In Situ Assay Products

Orthologs for KLHL31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL31 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia KLHL31 35
  • 91.13 (n)
  • 92.63 (a)
KLHL31 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl31 35
  • 87.13 (n)
  • 91.99 (a)
Klhl31 16
Klhl31 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHL31 35
  • 99.26 (n)
  • 99.05 (a)
KLHL31 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl31 35
  • 87.34 (n)
  • 91.35 (a)
cow
(Bos Taurus)
Mammalia KLHL31 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL31 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves KLHL31 35
  • 77.07 (n)
  • 84.15 (a)
KLHL31 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL31 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl31 35
  • 73.93 (n)
  • 80.77 (a)
zebrafish
(Danio rerio)
Actinopterygii klhl31 35
  • 69.82 (n)
  • 75.48 (a)
klhl31 36
  • 76 (a)
OneToOne
Species with no ortholog for KLHL31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL31 Gene

ENSEMBL:
Gene Tree for KLHL31 (if available)
TreeFam:
Gene Tree for KLHL31 (if available)

Paralogs for KLHL31 Gene

(12) SIMAP similar genes for KLHL31 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHL31: view

Variants for KLHL31 Gene

Sequence variations from dbSNP and Humsavar for KLHL31 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6908377 - 53,655,241(+) CTTTG(C/T)TCTTT reference, missense
rs3799260 - 53,654,807(-) CTCTT(A/G)TAAAG reference, missense
rs3799261 - 53,651,981(-) ACTGC(A/G)CGGTC reference, missense
rs997604 -- 53,649,264(+) CTCGC(C/T)AATGT utr-variant-3-prime
rs1326546 -- 53,653,833(+) TCTCT(A/G)GGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL31 Gene

Variant ID Type Subtype PubMed ID
nsv519037 CNV Loss 19592680
esv2732097 CNV Deletion 23290073

Variation tolerance for KLHL31 Gene

Residual Variation Intolerance Score: 72.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL31 Gene

HapMap Linkage Disequilibrium report
KLHL31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL31 Gene

Disorders for KLHL31 Gene

Relevant External Links for KLHL31

Genetic Association Database (GAD)
KLHL31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL31

No disorders were found for KLHL31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL31 Gene

Publications for KLHL31 Gene

  1. A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. (PMID: 15302408) Wu Y.L. … Gong Z. (Gene 2004) 3 4 23 67
  2. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE. (PMID: 18719355) Yu W. … Wu X. (Mol. Cells 2008) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for KLHL31 Gene

Sources for KLHL31 Gene

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