Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KLHL31 Gene

protein-coding   GIFtS: 48
GCID: GC06M053513

Kelch-Like Family Member 31

(Previous names: kelch repeat and BTB (POZ) domain containing 1, kelch-like...)
(Previous symbol: KBTBD1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Kelch-Like Family Member 311 2     BKLHD62 3
KBTBD11 2 3     BTB And Kelch Domain-Containing Protein 62 3
KLHL2 3 5     Kelch-Like 31 (Drosophila)1
Kelch Repeat And BTB (POZ) Domain Containing 11 2     bA345L23.22
Kelch Repeat And BTB Domain-Containing Protein 12 3     Kelch-Like Protein 312
Kelch-Like Protein KLHL2 3     

External Ids:    HGNC: 213531   Entrez Gene: 4012652   Ensembl: ENSG000001247437   OMIM: 6107495   UniProtKB: Q9H5113   

Export aliases for KLHL31 gene to outside databases

Previous GC identifers: GC06M053625 GC06M053344


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KLHL31 Gene:
KLHL31 (kelch-like family member 31) is a protein-coding gene. An important paralog of this gene is KLHL42.

UniProtKB/Swiss-Prot: KLH31_HUMAN, Q9H511
Function: Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression
inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL31 gene promoter:
         MEF-2   CUTL1   Roaz   C/EBPalpha   MEF-2A   RORalpha1   POU2F1   HOXA5   POU2F1a   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL31 promoter sequence
   Search Chromatin IP Primers for KLHL31

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL31


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.1

KLHL31 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL31 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M053513:  view genomic region     (about GC identifiers)

Start:
53,512,699 bp from pter      End:
53,530,506 bp from pter
Size:
17,808 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KLH31_HUMAN, Q9H511 (See protein sequence)
Recommended Name: Kelch-like protein 31  
Size: 634 amino acids; 70246 Da
Secondary accessions: A6N9J2 B2RP49

Explore the universe of human proteins at neXtProt for KLHL31: NX_Q9H511

Explore proteomics data for KLHL31 at MOPED

Post-translational modifications: 

  • N-terminus is methylated by METTL11A/NTM1 (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLHL31 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001003760.2  
    ENSEMBL proteins: 
     ENSP00000384644   ENSP00000359942  

    KLHL31 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KLHL31
    OriGene Protein Over-expression Lysate for KLHL31
    OriGene MassSpec for KLHL31
    OriGene Custom Protein Services for KLHL31
    GenScript Custom Purified and Recombinant Proteins Services for KLHL31
    Novus Biologicals KLHL31 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLHL31

     
    Search eBioscience for Proteins for KLHL31 

    KLHL31 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLHL31
    Novus Biologicals KLHL31 Antibodies
    Abcam antibodies for KLHL31
    Cloud-Clone Corp. Antibodies for KLHL31
    Search ThermoFisher Antibodies for KLHL31
    LSBio Antibodies in human, mouse, rat for KLHL31

    KLHL31 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLHL31
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLHL31
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLHL31
    Cloud-Clone Corp. CLIAs for KLHL31
    Search eBioscience for ELISAs for KLHL31 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9H511

    ProtoNet protein and cluster: Q9H511

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011498 Kelch
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH31_HUMAN, Q9H511
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Find genes that share domains with KLHL31           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH31_HUMAN, Q9H511
    Function: Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression
    inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KLHL31           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL31:
     Increased cell death in DLD-1  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL31
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLHL31

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL31
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL31

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLHL31:
    hsa-mir-218-5p (MIRT046987)

    Block miRNA regulation of human, mouse, rat KLHL31 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL31 (see all 48):
    hsa-miR-3130-5p hsa-miR-4307 hsa-miR-607 hsa-miR-4254 hsa-let-7d hsa-miR-513a-5p hsa-miR-128 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidKLHL31 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLHL31
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL31

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLHL31

    Clone
    Products:
         
    OriGene clones in human, mouse for KLHL31 (see all 5)
    OriGene ORF clones in mouse, rat for KLHL31
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL31 (NM_001003760)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL31
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL31

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLHL31
    Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL31 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL31


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL31
    Interactions:

        Search GeneGlobe Interaction Network for KLHL31

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with KLHL31           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL31 (KLH31)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KLHL31 gene: 
    NM_001003760.4  

    Unigene Cluster for KLHL31:

    Kelch-like family member 31
    Hs.131064  [show with all ESTs]
    Unigene Representative Sequence: NM_001003760
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407079 ENST00000370905(uc003pcb.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLHL31 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL31 (see all 48):
    hsa-miR-3130-5p hsa-miR-4307 hsa-miR-607 hsa-miR-4254 hsa-let-7d hsa-miR-513a-5p hsa-miR-128 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidKLHL31 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLHL31
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL31
    Clone
    Products:
         
    OriGene clones in human, mouse for KLHL31 (see all 5)
    OriGene ORF clones in mouse, rat for KLHL31
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL31 (NM_001003760)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL31
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL31
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL31
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL31
      QuantiTect SYBR Green Assays in human, mouse, rat KLHL31
      QuantiFast Probe-based Assays in human, mouse, rat KLHL31

    Additional mRNA sequence: 

    BC137267.1 BC137269.1 EF633513.1 

    2 DOTS entries:

    DT.40262426  DT.86857662 

    4 AceView cDNA sequences:

    NM_001003760 AW294693 BF824983 R57328 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KLHL31 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAAAAACC
    KLHL31 Expression
    About this image


    KLHL31 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
    KLHL31 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL31 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131064

    UniProtKB/Swiss-Prot: KLH31_HUMAN, Q9H511
    Tissue specificity: Strongly expressed in skeletal muscle and weakly in heart. According to PubMed:15302408, not
    expressed in other tissues. According to PubMed:18719355, abundantly expressed in both embryonic skeletal and
    heart tissues

        Custom PCR Arrays for KLHL31
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL31
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL31
    QuantiTect SYBR Green Assays in human, mouse, rat KLHL31
    QuantiFast Probe-based Assays in human, mouse, rat KLHL31
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL31

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL31 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl311 , 5 kelch-like 31 (Drosophila)5
    kelch-like 311
    87.13(n)1
    91.99(a)1
      9 (43.36 cM)5
    2449231  NM_172925.21  NP_766513.21 
     776365005 
    chicken
    (Gallus gallus)
    Aves KLHL311 kelch-like 31 (Drosophila) 77.07(n)
    84.15(a)
      421893  XM_419909.4  XP_419909.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL316
    kelch-like family member 31
    70(a)
    1 ↔ 1
    1(151315951-151356897)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klhl311 kelch-like family member 31 73.93(n)
    80.77(a)
      100495906  XM_002934853.2  XP_002934899.1 
    zebrafish
    (Danio rerio)
    Actinopterygii klhl311 kelch-like 31 (Drosophila) 69.82(n)
    75.48(a)
      407079  NM_001003727.2  NP_001003727.1 


    ENSEMBL Gene Tree for KLHL31 (if available)
    TreeFam Gene Tree for KLHL31 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KLHL31 gene
    KLHL422  KLHL132  KLHL222  KLHL262  KLHL342  KBTBD132  KBTBD112  KLHL322  
    KLHL92  KLHL142  KLHL152  KLHDC7B2  KLHL362  KLHL332  KLHDC7A2  
    12 SIMAP similar genes for KLHL31 using alignment to 1 protein entry:     KLH31_HUMAN:
    KLHL9    DKFZp686L0695    KLHL13    KLHL26    KLHL36    KLHL17
    KLHL28    KLHL15    KLHL22    KLHL32    KLHL14    KLHL18

    Find genes that share paralogs with KLHL31           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KLHL31 (see all 568)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734438111,2
    C,F--53512300(+) TTACTT/CGCTCA 1 -- ds50012Minor allele frequency- C:0.04WA 120
    rs1158630061,2
    C,F--53512320(+) GTAAGG/ATAGAA 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1924084961,2
    C--53512398(+) TGATGA/GTGAAC 1 -- ds50010--------
    rs1153021091,2
    F--53512442(+) AGGAAG/AAGAAA 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1848598031,2
    --53512472(+) TCTAAA/GTAGTC 1 -- ds50010--------
    rs43085561,2
    H--53512486(+) GCTGAG/TCTAGA 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
    rs1388197781,2
    --53512498(+) CAGAGC/TTGGGC 1 -- ds50010--------
    rs1422018481,2
    --53512621(+) TCTAGA/GTGAAT 1 -- ds50010--------
    rs1880108151,2
    --53512699(+) GTCCAC/TATTTA 1 -- ut310--------
    rs589865311,2
    C,F--53512724(+) TCTTAT/CTGAAT 1 -- ut316Minor allele frequency- C:0.17WA CSA NA EA 364

    HapMap Linkage Disequilibrium report for KLHL31 (53512699 - 53530506 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLHL31:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732097CNV Deletion23290073
    nsv519037CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL31
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL31

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610749    OMIM disorders: --


    Find genes that share disorders with KLHL31           About GenesLikeMe

    Genetic Association Database (GAD): KLHL31

    Export disorders for KLHL31 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KLHL31 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KLHL31)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. (PubMed id 15302408)1, 2, 9 Wu Y.L. and Gong Z. (Gene 2004)
    2. A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE. (PubMed id 18719355)1, 2 Yu W.... Wu X. (Mol. Cells 2008)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 401265 HGNC: 21353 AceView: KLHL.1 Ensembl:ENSG00000124743 euGenes: HUgn401265
    ECgene: KLHL31 H-InvDB: KLHL31

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KLHL31 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KLHL31 gene:
    Search GeneIP for patents involving KLHL31

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLHL31  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KLHL31  
     OriGene MassSpec something-or-other for KLHL31   OriGene clones in human, mouse for KLHL31  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLHL31   OriGene Purified Protein for KLHL31  
     OriGene ORF clones in mouse, rat for KLHL31   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLHL31   OriGene Custom Protein Services for KLHL31  

     
     
     Block miRNA regulation of human, mouse, rat KLHL31 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLHL31
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL31 Predesigned siRNA for gene silencing in human, mouse, rat KLHL31
     QuantiFast Probe-based Assays in human, mouse, rat KLHL31 QuantiTect SYBR Green Assays in human, mouse, rat KLHL31
     Custom PCR Arrays for KLHL31 Search Chromatin IP Primers for KLHL31
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL31  Search GeneGlobe Interaction Network for KLHL31
     Regulatory tfbs in KLHL31 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KLHL31 GenScript cDNA clones with any tag delivered in your preferred vector for KLHL31
     GenScript Custom Assay Services for KLHL31 GenScript Custom overexpressing Cell Line Services for KLHL31
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KLHL31 (KLH31)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KLHL31 antibodies
     KLHL31 lysates
     Antibodies for KLHL31
     See all of Abcam's Antibodies, Kits and Proteins for KLHL31
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KLHL31
     Antibodies for KLHL31
     ELISAs for KLHL31
     CLIAs for KLHL31



     Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL31
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL31
     SwitchGear 3'UTR luciferase reporter plasmids for KLHL31
     SwitchGear Promoter luciferase reporter plasmids for KLHL31
     Search ThermoFisher Antibodies for KLHL31
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL31
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL31
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLHL31
     LSBio Antibodies in human, mouse, rat for KLHL31
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for KLHL31
      Search eBioscience for proteins for KLHL31
      Search eBioscience for elisas for KLHL31
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLHL31 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4