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Aliases for KLHL29 Gene

Aliases for KLHL29 Gene

  • Kelch Like Family Member 29 2 3 5
  • Kelch Repeat And BTB Domain-Containing Protein 9 3 4
  • Kelch Repeat And BTB (POZ) Domain Containing 9 2 3
  • KBTBD9 3 4
  • Kelch-Like Family Member 29 3
  • Kelch-Like 29 (Drosophila) 2
  • Kelch-Like 29 3
  • KIAA1921 4

External Ids for KLHL29 Gene

Previous HGNC Symbols for KLHL29 Gene

  • KBTBD9

Previous GeneCards Identifiers for KLHL29 Gene

  • GC02P023460
  • GC02P023608

Summaries for KLHL29 Gene

GeneCards Summary for KLHL29 Gene

KLHL29 (Kelch Like Family Member 29) is a Protein Coding gene. An important paralog of this gene is KBTBD4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL29 Gene

Genomics for KLHL29 Gene

Regulatory Elements for KLHL29 Gene

Enhancers for KLHL29 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL29 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL29 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL29 Gene

Chromosome:
2
Start:
23,385,217 bp from pter
End:
23,708,613 bp from pter
Size:
323,397 bases
Orientation:
Plus strand

Genomic View for KLHL29 Gene

Genes around KLHL29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL29 Gene

Proteins for KLHL29 Gene

  • Protein details for KLHL29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CT2-KLH29_HUMAN
    Recommended name:
    Kelch-like protein 29
    Protein Accession:
    Q96CT2
    Secondary Accessions:
    • Q8N388
    • Q96BF0
    • Q96PW7

    Protein attributes for KLHL29 Gene

    Size:
    875 amino acids
    Molecular mass:
    94228 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13982.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH15667.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB67814.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAD39171.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL29 Gene

Proteomics data for KLHL29 Gene at MOPED

Post-translational modifications for KLHL29 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL29 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL29 Gene

Domains & Families for KLHL29 Gene

Gene Families for KLHL29 Gene

Protein Domains for KLHL29 Gene

Suggested Antigen Peptide Sequences for KLHL29 Gene

Graphical View of Domain Structure for InterPro Entry

Q96CT2

UniProtKB/Swiss-Prot:

KLH29_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL29: view

Function for KLHL29 Gene

Gene Ontology (GO) - Molecular Function for KLHL29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL29: view
genes like me logo Genes that share phenotypes with KLHL29: view

Animal Models for KLHL29 Gene

MGI Knock Outs for KLHL29:

Animal Model Products

miRNA for KLHL29 Gene

miRTarBase miRNAs that target KLHL29

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHL29 Gene

Localization for KLHL29 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL29 Gene COMPARTMENTS Subcellular localization image for KLHL29 gene
Compartment Confidence
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL29 Gene

Pathways & Interactions for KLHL29 Gene

SuperPathways for KLHL29 Gene

No Data Available

Interacting Proteins for KLHL29 Gene

Gene Ontology (GO) - Biological Process for KLHL29 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KLHL29 Gene

Drugs & Compounds for KLHL29 Gene

No Compound Related Data Available

Transcripts for KLHL29 Gene

mRNA/cDNA for KLHL29 Gene

(4) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL29 Gene

Kelch-like family member 29:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL29 Gene

No ASD Table

Relevant External Links for KLHL29 Gene

GeneLoc Exon Structure for
KLHL29
ECgene alternative splicing isoforms for
KLHL29

Expression for KLHL29 Gene

mRNA expression in normal human tissues for KLHL29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL29 Gene

This gene is overexpressed in Plasma (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL29 Gene



SOURCE GeneReport for Unigene cluster for KLHL29 Gene Hs.130593

genes like me logo Genes that share expression patterns with KLHL29: view

Protein tissue co-expression partners for KLHL29 Gene

- Elite partner

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL29 Gene

Orthologs for KLHL29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL29 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHL29 35
  • 92.27 (n)
  • 96.46 (a)
KLHL29 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL29 35
  • 93.64 (n)
  • 97.49 (a)
KLHL29 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl29 35
  • 90.32 (n)
  • 97.03 (a)
Klhl29 16
Klhl29 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHL29 35
  • 99.66 (n)
  • 99.89 (a)
KLHL29 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl29 35
  • 91.09 (n)
  • 97.83 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL29 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL29 35
  • 79.06 (n)
  • 85.8 (a)
KLHL29 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL29 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl29 35
  • 74.27 (n)
  • 80.32 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334314 35
  • 71.83 (n)
  • 73.71 (a)
KLHL29 36
  • 75 (a)
OneToMany
KLHL29 (1 of 2) 36
  • 73 (a)
OneToMany
Species with no ortholog for KLHL29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL29 Gene

ENSEMBL:
Gene Tree for KLHL29 (if available)
TreeFam:
Gene Tree for KLHL29 (if available)

Paralogs for KLHL29 Gene

genes like me logo Genes that share paralogs with KLHL29: view

Variants for KLHL29 Gene

Sequence variations from dbSNP and Humsavar for KLHL29 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs472798 -- 23,601,749(+) TAGGT(C/T)CCCAG intron-variant
rs473553 -- 23,627,298(+) GGGGC(C/T)AAAGA intron-variant
rs475309 -- 23,627,443(+) CCACC(A/G)CGGAG intron-variant
rs477284 -- 23,627,705(+) AGGTC(A/G)CTGAG intron-variant
rs482525 -- 23,637,670(+) GCGTC(A/G)AAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL29 Gene

Variant ID Type Subtype PubMed ID
nsv873730 CNV Gain 21882294
esv27159 CNV Loss 19812545
esv2552237 CNV Deletion 19546169
nsv833570 CNV Gain 17160897
esv9475 CNV Gain 19470904
nsv873731 CNV Loss 21882294
esv2719812 CNV Deletion 23290073
nsv873732 CNV Loss 21882294
nsv214546 CNV Loss 16902084
esv2639907 CNV Deletion 19546169
esv1295316 CNV Deletion 17803354
nsv2639 CNV Insertion 18451855
nsv527636 CNV Gain 19592680
nsv455886 CNV Loss 19166990
esv2719813 CNV Deletion 23290073

Variation tolerance for KLHL29 Gene

Gene Damage Index Score: 2.80; 47.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLHL29 Gene

Disorders for KLHL29 Gene

Relevant External Links for KLHL29

Genetic Association Database (GAD)
KLHL29
Human Genome Epidemiology (HuGE) Navigator
KLHL29
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL29

No disorders were found for KLHL29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL29 Gene

Publications for KLHL29 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  3. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for KLHL29 Gene

Sources for KLHL29 Gene

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