KLHL29 Gene
protein-coding GIFtS : 40
GCID: GC02 P023608
kelch-like family member 29 (Previous names: kelch repeat and BTB (POZ) domain containing 9, kelch-like... ) (Previous symbol: KBTBD9 )
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Aliasesfor KLHL29 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Kelch-Like Family Member 29 1 2 Kelch Repeat And BTB Domain-Containing Protein 92 3 KBTBD91 2 3 Kelch-Like 29 (Drosophila)1 Kelch Repeat And BTB (POZ) Domain Containing 91 2 Kelch-Like 292 KIAA19211 3 Kelch-Like Protein 292
Export aliases for KLHL29 gene to outside databases Previous GC identifers: GC02P023460 GC02P023348
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Summariesfor KLHL29 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor KLHL29 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022184.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KLHL29 gene promoter: TBP Spz1 NRSF form 1 AP-2gamma NRSF form 2 Nkx6-1 AP-2beta STAT3 AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for KLHL29 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KLHL29
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p24.1 Ensembl cytogenetic band: 2p24.1 HGNC cytogenetic band: 2p23.3 KLHL29 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P023608: view genomic region
(about GC identifiers )
Start:
23,608,088 bp from pter
End:
23,931,483 bp from pter
Size:
323,396 bases
Orientation:
plus strand
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Proteinsfor KLHL29 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KLH29_HUMAN, Q96CT2 (See
protein sequence )Recommended Name: Kelch-like protein 29 Size : 655 amino acids; 71468 Da
Caution : Although the complete sequence is not known with certainty, sequence shown here appears to be the mostprobable in accordance with the mouse sequence ortholog
Sequence caution : Sequence=AAH13982.1; Type=Erroneous initiation; Sequence=AAH15667.1; Type=Erroneous initiation;Sequence=CAD39171.2; Type=Erroneous initiation;
Secondary accessions : Q8N388 Q96BF0 Q96PW7Alternative splicing : 2 isoforms : Q96CT2-1 Q96CT2-2 Explore the universe of human proteins at neXtProt for KLHL29: NX_Q96CT2 KLHL29 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_443152.1 ENSEMBL proteins: ENSP00000420659 ENSP00000288548 Human Recombinant Protein Products for KLHL29: KLHL29 Antibody Products: Assay Products for KLHL29:
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Protein
Domains / Familiesfor KLHL29 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KLHL29 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q96CT2 ProtoNet protein and cluster: Q96CT2
3 Blocks protein families : IPB000210 BTB/POZ domain IPB011498 Kelch IPB011705 BTB/Kelch-associated UniProtKB/Swiss-Prot: KLH29_HUMAN, Q96CT2 Similarity : Contains 1 BTB (POZ) domainSimilarity : Contains 6 Kelch repeats
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Functionfor KLHL29 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL29 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL29OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLHL29 (NM_052920 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL29 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLHL29
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL29
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Pathways & Interactionsfor KLHL29 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL29
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Drugs & Compoundsfor KLHL29 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KLHL29 Search CenterWatch for drugs/clinical trials and news about KLHL29 / KLH29
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Transcriptsfor KLHL29 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KLHL29 gene (2 alternative transcripts): NM_025067.1 NM_052920.1 Unigene Cluster for KLHL29:
Kelch-like 29 (Drosophila) Hs.130593 [show with all ESTs ] Unigene Representative Sequence: NM_052920 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000486442 (uc010ykg.2 ) ENST00000489446 (uc002ref.3 ) ENST00000288548 (uc002reg.3 )ENST00000471654 (uc010ykh.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL29 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL29OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLHL29 (NM_052920 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL29 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLHL29
Additional cDNA sequence: AK094600.1 AL834515.1 BC013982.1 BC015667.2 BC069271.1
7 DOTS entries : DT.211114 DT.91850662
DT.91952086 DT.99975266 DT.425307 DT.75180043 DT.91747473 1 AceView cDNA sequence :
BX424349 GeneLoc Exon Structure
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Expression for KLHL29 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KLHL29 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGGGGCGTGGAbout this image KLHL29 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Kidney S-shaped Body Kidney Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
See KLHL29 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KLHL29 SOURCE GeneReport for Unigene cluster: Hs.130593 SABiosciences Custom PCR Arrays for KLHL29 Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KLHL29 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KLHL29 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KLHL29 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL29
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Orthologsfor KLHL29 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for KLHL29 gene from 4/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for KLHL29 (if available)TreeFam Gene Tree for KLHL29 (if available)
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Paralogsfor KLHL29 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KLHL29 gene KLHL38 2 KLHL21 2 KLHL6 2 KLHL23 2 KBTBD3 2 KLHL11 2 KLHL24 2 KLHL25 2 KLHL30 2 KLHL35 2 ENC1 2 CCIN 2 18/23 SIMAP similar genes for KLHL29 using alignment to 3 protein entries: KLH29_HUMAN (see all proteins )
(see all similar genes ):FLJ14106 ZBTB7C KLHL3 BACH2 KLHL24 MYNN KLHL20 ZBTB21 KLHL18 KLHL21 KLHL7 KLHL12 KLHL2 KLHL25 KLHL38 KLHL32 KLHL17 KLHL28
KLHL29 for paralogs About GeneDecksing
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Genomic Variantsfor KLHL29 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KLHL29 (23608088 - 23858088 bp, first 250kb of KLHL29)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for KLHL29 4 CNVs : 5971 89532 97792 73010 2 Indels : 60289 26595
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KLHL29
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Disorders
/ Diseasesfor KLHL29 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section KLHL29 for disorders About MalaCards
KLHL29 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: KLHL29 (5 documents) Export disorders for KLHL29 gene to outside databases
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Publicationsfor KLHL29 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KLHL29 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with KLHL29) Utopia : connect your pdf to the dynamic world of online information
Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484) 1 , 2 , 3 Nagase T....Ohara O. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Genome-wide association study of coronary heart disea se and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282) 1 Lettre G....Boerwinkle E. (2011) Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767) 1 Murea M....Freedman B.I. (2011) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 Bailey S.D....Anand S. (2010) Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121) 1 Talmud P.J.... . (2009) Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061) 1 Trynka G....Wijmenga C. (2009) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004)
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External Searches for KLHL29 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KLHL29 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KLHL29 gene
(According to HUGE )
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Specialized Databases showing KLHL29 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KLHL29 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KLHL29 gene: Search GeneIP for patents involving KLHL29 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KLHL29 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KLHL29 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KLHL29 Browse OriGene genome-wide validated SYBR primer pairs OriGene Protein Over-expression Lysate for KLHL29 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KLHL29 OriGene 3'-UTR Clone for KLHL29 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL29 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLHL29 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KLHL29 OriGene Custom Protein Services for KLHL29 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL29 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KLHL29 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KLHL29 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KLHL29 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KLHL29 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KLHL29
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KLHL29 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL29
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLHL29
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