KLHL28 Gene
protein-coding GIFtS: 43
GCID: GC14M045393
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kelch-like family member 28(Previous names: BTB (POZ) domain containing 5, kelch-like 28 (Drosophila)...)
(Previous symbol: BTBD5)
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Aliases
for KLHL28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 281 2 | | FLJ200811 | | BTBD51 2 3 | | Kelch-Like 28 (Drosophila)1 | | BTB (POZ) Domain Containing 51 2 | | Kelch-Like 282 | | BTB/POZ Domain-Containing Protein 52 3 | | Kelch-Like Protein 282 |
Export aliases for KLHL28 gene to outside databasesPrevious GC identifers: GC14M044468 GC14M025504 |
Summaries
for KLHL28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLHL28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL28 gene promoter:
Nkx3-1 E2F-3a E2F-4 E2F-5 Nkx3-1 v4 Nkx3-1 v1 E2F-2 Nkx3-1 v2 E2F-1 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL28
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL28 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q21.2 Ensembl cytogenetic band: 14q21.2 HGNC cytogenetic band: 14q21.1KLHL28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M045393: view genomic region
(about GC identifiers)
Start:
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45,393,527 bp from pter |
End:
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45,511,525 bp from pter |
Size:
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117,999 bases |
Orientation:
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minus strand |
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Proteins
for KLHL28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLH28_HUMAN, Q9NXS3 (See
protein sequence)Recommended Name: Kelch-like protein 28 Size: 571 amino acids; 64192 Da
Secondary accessions: Q0VAL5Alternative splicing: 2 isoforms: Q9NXS3-1 Q9NXS3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KLHL28: NX_Q9NXS3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXS3
KLHL28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060128.2
ENSEMBL proteins: ENSP00000379434 ENSP00000347193 ENSP00000462025 ENSP00000452061 ENSP00000452591 ENSP00000450788
Human Recombinant Protein Products:
KLHL28 Antibody Products:
Assay Products for KLHL28: |
Protein
Domains /
Families
for KLHL28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHL28 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9NXS3ProtoNet protein and cluster: Q9NXS3 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KLH28_HUMAN, Q9NXS3Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats |
Function
for KLHL28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL28 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL28
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLHL28 (NM_017658) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL28 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL28 |
2 GenomeRNAi human phenotypes for KLHL28:
|
Pathways & Interactions
for KLHL28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL28
2 Interacting proteins for KLHL28 (Q9NXS33) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KLHL28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL28
Search CenterWatch for drugs/clinical trials and news about KLHL28 / KLH28
|
Transcripts
for KLHL28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL28 gene: NM_017658.3 Unigene Cluster for KLHL28: Kelch-like 28 (Drosophila) Hs.550906 [show with all ESTs]Unigene Representative Sequence: NM_0176587 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396128(uc001wvq.3 uc001wvr.3) ENST00000355081 ENST00000579157
ENST00000556500 ENST00000556239 ENST00000557468 ENST00000553817
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL28 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL28
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHL28 (NM_017658) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL28 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL28 |
Additional cDNA sequence: AK090972.1 AK289855.1 BC012473.2 BC057794.1 BC121009.1 BC121010.1 7 DOTS entries: DT.408682 DT.92418158 DT.97794569 DT.40131028 DT.40310257 DT.100690232 DT.40119719 24/41 AceView cDNA sequences (see all 41): AA459463 BP350853 AI247249 NM_017658 AA705318 AW294280 AI277394 BX118266 BC012473 CA433205 AW270960 AI349316 AA459242 BU543670 BC057794 BP351027 BQ710953 AL713035 BP359589 AW118922 BX461237 AA455180 BI222474 AK000088
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL28 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 |
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KLHL28
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Expression
for KLHL28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCTTTTTA
About this image
See KLHL28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL28
SOURCE GeneReport for Unigene cluster: Hs.550906
SABiosciences Custom PCR Arrays for KLHL28
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL28
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL28 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL28 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL28 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL28 |
Orthologs
for KLHL28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KLHL28 gene from 4/19 species (see all 19) About this table
ENSEMBL Gene Tree for KLHL28 (if available)
TreeFam Gene Tree for KLHL28 (if available) |
Paralogs
for KLHL28 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL28 gene
- KLHL172 KLHL182 KLHL202 KLHL52 KLHL122 KEAP12 KLHL42 IPP2
- KLHL32 KLHL82 KLHL102 KLHL12 KLHL22
18/51 SIMAP similar genes for KLHL28 using alignment to 6 protein entries: KLH28_HUMAN (see all proteins)
(see all similar genes):KLHL14 ZBTB44 KBTBD8 ZBTB21 ZNF295 KLHL20
KLHL17 KBTBD3 KLHL3 KLHL4 KLHL1 KLHL5
KLHL12 HIC1 KLHL2 KLHL32 ZBTB3 ZBTB14
KLHL28 for paralogs About GeneDecksing
|
Genomic Variants
for KLHL28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHL28 (45393527 - 45511525 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KLHL28
1 Indel: 58675 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL28 |
|
Disorders
/ Diseases
for KLHL28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KLHL28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL28 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHL28) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KLHL28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KLHL28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL28 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHL28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL28 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KLHL28 gene:
Search GeneIP for patents involving KLHL28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLHL28 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL28 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL28 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLHL28 | | OriGene 3'-UTR Clone for KLHL28 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL28 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL28 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | KLHL28 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL28 |
|  |  |  | | | | Search ThermoFisher Antibodies for KLHL28 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL28 |
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