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Aliases for KLHL28 Gene

Aliases for KLHL28 Gene

  • Kelch-Like Family Member 28 2 3
  • BTB/POZ Domain-Containing Protein 5 3 4
  • BTB (POZ) Domain Containing 5 2 3
  • BTBD5 3 4
  • Kelch-Like 28 (Drosophila) 2
  • Kelch-Like Protein 28 3
  • Kelch-Like 28 3

External Ids for KLHL28 Gene

Previous HGNC Symbols for KLHL28 Gene

  • BTBD5

Previous GeneCards Identifiers for KLHL28 Gene

  • GC14M044468
  • GC14M045393
  • GC14M025504

Summaries for KLHL28 Gene

GeneCards Summary for KLHL28 Gene

KLHL28 (Kelch-Like Family Member 28) is a Protein Coding gene. An important paralog of this gene is KLHL10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL28 Gene

Genomics for KLHL28 Gene

Regulatory Elements for KLHL28 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL28 Gene

Start:
44,924,319 bp from pter
End:
45,042,322 bp from pter
Size:
118,004 bases
Orientation:
Minus strand

Genomic View for KLHL28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL28 Gene

Proteins for KLHL28 Gene

  • Protein details for KLHL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXS3-KLH28_HUMAN
    Recommended name:
    Kelch-like protein 28
    Protein Accession:
    Q9NXS3
    Secondary Accessions:
    • Q0VAL5

    Protein attributes for KLHL28 Gene

    Size:
    571 amino acids
    Molecular mass:
    64192 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLHL28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL28 Gene

Proteomics data for KLHL28 Gene at MOPED

Post-translational modifications for KLHL28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL28 Gene

No data available for DME Specific Peptides for KLHL28 Gene

Domains for KLHL28 Gene

Gene Families for KLHL28 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXS3

UniProtKB/Swiss-Prot:

KLH28_HUMAN :
  • Q9NXS3
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL28: view

Function for KLHL28 Gene

Gene Ontology (GO) - Molecular Function for KLHL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL28: view

Phenotypes for KLHL28 Gene

GenomeRNAi human phenotypes for KLHL28:
genes like me logo Genes that share phenotypes with KLHL28: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL28

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL28 Gene

Localization for KLHL28 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL28 Gene COMPARTMENTS Subcellular localization image for KLHL28 gene
Compartment Confidence
cytosol 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL28 Gene

Pathways for KLHL28 Gene

SuperPathways for KLHL28 Gene

No Data Available

Interacting Proteins for KLHL28 Gene

Gene Ontology (GO) - Biological Process for KLHL28 Gene

None

No data available for Pathways by source for KLHL28 Gene

Transcripts for KLHL28 Gene

Unigene Clusters for KLHL28 Gene

Kelch-like family member 28:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL28

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KLHL28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL28 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: -
SP2:
SP3: - -
SP4:
SP5: - -
SP6: -

Relevant External Links for KLHL28 Gene

GeneLoc Exon Structure for
KLHL28
ECgene alternative splicing isoforms for
KLHL28

Expression for KLHL28 Gene

mRNA expression in normal human tissues for KLHL28 Gene

SOURCE GeneReport for Unigene cluster for KLHL28 Gene Hs.550906

genes like me logo Genes that share expressions with KLHL28: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for KLHL28 Gene

Orthologs for KLHL28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL28 35
  • 99.77 (n)
  • 99.65 (a)
KLHL28 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHL28 35
  • 94.63 (n)
  • 99.12 (a)
KLHL28 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL28 35
  • 95.62 (n)
  • 99.12 (a)
KLHL28 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl28 35
  • 91.13 (n)
  • 97.02 (a)
Klhl28 16
Klhl28 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL28 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL28 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl28 35
  • 91.3 (n)
  • 97.55 (a)
chicken
(Gallus gallus)
Aves KLHL28 35
  • 80.27 (n)
  • 92.64 (a)
KLHL28 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL28 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl28 35
  • 79.16 (n)
  • 87.39 (a)
zebrafish
(Danio rerio)
Actinopterygii klhl28 35
  • 68.88 (n)
  • 83.4 (a)
KLHL28 36
  • 82 (a)
OneToOne
Species with no ortholog for KLHL28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL28 Gene

ENSEMBL:
Gene Tree for KLHL28 (if available)
TreeFam:
Gene Tree for KLHL28 (if available)

Paralogs for KLHL28 Gene

genes like me logo Genes that share paralogs with KLHL28: view

Variants for KLHL28 Gene

Sequence variations from dbSNP and Humsavar for KLHL28 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1955669 -- 44,926,787(+) acagg(C/G)gtgag utr-variant-3-prime
rs6572290 -- 44,927,962(+) TTGGC(A/G)TAATC utr-variant-3-prime
rs6572291 -- 44,951,903(+) tggcc(A/G)gggtg intron-variant
rs7145870 -- 44,951,761(+) AAACA(A/G)TGTCA intron-variant
rs7151557 -- 44,926,663(+) CACAA(C/T)GCCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL28 Gene

Variant ID Type Subtype PubMed ID
nsv901832 CNV Loss 21882294
nsv901841 CNV Loss 21882294
nsv819173 CNV Loss 19587683
nsv1259 CNV Loss 18451855

Relevant External Links for KLHL28 Gene

HapMap Linkage Disequilibrium report
KLHL28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL28 Gene

Disorders for KLHL28 Gene

No disorders were found for KLHL28 Gene.

No data available for UniProtKB/Swiss-Prot for KLHL28 Gene

Publications for KLHL28 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for KLHL28 Gene

Sources for KLHL28 Gene

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