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Aliases for KLHL28 Gene

Aliases for KLHL28 Gene

  • Kelch Like Family Member 28 2 3 5
  • BTB/POZ Domain-Containing Protein 5 3 4
  • BTB (POZ) Domain Containing 5 2 3
  • BTBD5 3 4
  • Kelch-Like Family Member 28 3
  • Kelch-Like 28 (Drosophila) 2
  • Kelch-Like 28 3

External Ids for KLHL28 Gene

Previous HGNC Symbols for KLHL28 Gene

  • BTBD5

Previous GeneCards Identifiers for KLHL28 Gene

  • GC14M044468
  • GC14M045393
  • GC14M025504

Summaries for KLHL28 Gene

GeneCards Summary for KLHL28 Gene

KLHL28 (Kelch Like Family Member 28) is a Protein Coding gene. An important paralog of this gene is KLHL5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL28 Gene

Genomics for KLHL28 Gene

Regulatory Elements for KLHL28 Gene

Genomic Location for KLHL28 Gene

44,924,319 bp from pter
45,042,322 bp from pter
118,004 bases
Minus strand

Genomic View for KLHL28 Gene

Genes around KLHL28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL28 Gene

Proteins for KLHL28 Gene

  • Protein details for KLHL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 28
    Protein Accession:
    Secondary Accessions:
    • Q0VAL5

    Protein attributes for KLHL28 Gene

    571 amino acids
    Molecular mass:
    64192 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLHL28 Gene


neXtProt entry for KLHL28 Gene

Proteomics data for KLHL28 Gene at MOPED

Post-translational modifications for KLHL28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL28 Gene

No data available for DME Specific Peptides for KLHL28 Gene

Domains & Families for KLHL28 Gene

Gene Families for KLHL28 Gene

Suggested Antigen Peptide Sequences for KLHL28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL28: view

Function for KLHL28 Gene

Gene Ontology (GO) - Molecular Function for KLHL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL28: view

Phenotypes for KLHL28 Gene

genes like me logo Genes that share phenotypes with KLHL28: view

Animal Model Products

miRNA for KLHL28 Gene

miRTarBase miRNAs that target KLHL28

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL28 Gene

Localization for KLHL28 Gene

Subcellular locations from

Jensen Localization Image for KLHL28 Gene COMPARTMENTS Subcellular localization image for KLHL28 gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL28 Gene

Pathways & Interactions for KLHL28 Gene

SuperPathways for KLHL28 Gene

No Data Available

Interacting Proteins for KLHL28 Gene

Gene Ontology (GO) - Biological Process for KLHL28 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHL28 Gene

Drugs & Compounds for KLHL28 Gene

No Compound Related Data Available

Transcripts for KLHL28 Gene

Unigene Clusters for KLHL28 Gene

Kelch-like family member 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL28 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: -
SP3: - -
SP5: - -
SP6: -

Relevant External Links for KLHL28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL28 Gene

mRNA expression in normal human tissues for KLHL28 Gene

SOURCE GeneReport for Unigene cluster for KLHL28 Gene Hs.550906

genes like me logo Genes that share expression patterns with KLHL28: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KLHL28 Gene

Orthologs for KLHL28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL28 35
  • 94.63 (n)
  • 99.12 (a)
KLHL28 36
  • 99 (a)
(Canis familiaris)
Mammalia KLHL28 35
  • 95.62 (n)
  • 99.12 (a)
KLHL28 36
  • 99 (a)
(Mus musculus)
Mammalia Klhl28 35
  • 91.13 (n)
  • 97.02 (a)
Klhl28 16
Klhl28 36
  • 97 (a)
(Pan troglodytes)
Mammalia KLHL28 35
  • 99.77 (n)
  • 99.65 (a)
KLHL28 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Klhl28 35
  • 91.3 (n)
  • 97.55 (a)
(Monodelphis domestica)
Mammalia KLHL28 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL28 36
  • 82 (a)
(Gallus gallus)
Aves KLHL28 35
  • 80.27 (n)
  • 92.64 (a)
KLHL28 36
  • 92 (a)
(Anolis carolinensis)
Reptilia KLHL28 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl28 35
  • 79.16 (n)
  • 87.39 (a)
(Danio rerio)
Actinopterygii klhl28 35
  • 68.88 (n)
  • 83.4 (a)
KLHL28 36
  • 82 (a)
Species with no ortholog for KLHL28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL28 Gene

Gene Tree for KLHL28 (if available)
Gene Tree for KLHL28 (if available)

Paralogs for KLHL28 Gene

genes like me logo Genes that share paralogs with KLHL28: view

Variants for KLHL28 Gene

Sequence variations from dbSNP and Humsavar for KLHL28 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs35728857 - 44,934,413(-) TCACT(A/G)TCAGA reference, missense
rs1955669 -- 44,926,787(+) acagg(C/G/T)gtgag utr-variant-3-prime
rs6572290 -- 44,927,962(+) TTGGC(A/G)TAATC utr-variant-3-prime
rs6572291 -- 44,951,903(+) tggcc(A/G)gggtg intron-variant
rs7154959 -- 44,939,452(+) aagtc(C/T)ttctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL28 Gene

Variant ID Type Subtype PubMed ID
nsv901832 CNV Loss 21882294
nsv901841 CNV Loss 21882294
nsv819173 CNV Loss 19587683
nsv1259 CNV Loss 18451855

Variation tolerance for KLHL28 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL28 Gene

Disorders for KLHL28 Gene

Relevant External Links for KLHL28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL28 Gene

Publications for KLHL28 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for KLHL28 Gene

Sources for KLHL28 Gene

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