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Aliases for KLHL28 Gene

Aliases for KLHL28 Gene

  • Kelch Like Family Member 28 2 3 5
  • BTB/POZ Domain-Containing Protein 5 3 4
  • BTB (POZ) Domain Containing 5 2 3
  • BTBD5 3 4
  • Kelch-Like 28 (Drosophila) 2
  • Kelch-Like Protein 28 3
  • Kelch-Like 28 3

External Ids for KLHL28 Gene

Previous HGNC Symbols for KLHL28 Gene

  • BTBD5

Previous GeneCards Identifiers for KLHL28 Gene

  • GC14M044468
  • GC14M045393
  • GC14M025504

Summaries for KLHL28 Gene

GeneCards Summary for KLHL28 Gene

KLHL28 (Kelch Like Family Member 28) is a Protein Coding gene. An important paralog of this gene is KLHL20.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL28 Gene

Genomics for KLHL28 Gene

Regulatory Elements for KLHL28 Gene

Enhancers for KLHL28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F045249 1.5 FANTOM5 ENCODE 10.9 -209.7 -209708 6.0 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 MIS18BP1 FANCM FAM179B KLHL28 PRPF39 GC14M044793
GH14F045133 1.1 ENCODE 10.7 -92.9 -92890 3.5 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS C14orf28 KLHL28 ENSG00000258998 GC14M045133 SNORD127
GH14F045083 1 ENCODE 10.8 -42.3 -42328 2.4 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48 ZNF2 YY1 C14orf28 KLHL28 ENSG00000258998 PRPF39 ENSG00000212615
GH14F044988 0.6 Ensembl 12.3 +53.4 53422 0.2 OSR2 SMARCA4 POLR2A FEZF1 TRIM28 KLHL28 FAM179B ENSG00000212615 PRPF39 LOC105370474 GC14P044998
GH14F045138 0.4 FANTOM5 10.4 -96.2 -96151 0.4 PRDM1 ENSG00000212615 LOC105370474 PRPF39 KLHL28 FAM179B SNORD127 ENSG00000258998 FANCM GC14M044793
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL28 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL28 Gene

Chromosome:
14
Start:
44,924,319 bp from pter
End:
45,042,322 bp from pter
Size:
118,004 bases
Orientation:
Minus strand

Genomic View for KLHL28 Gene

Genes around KLHL28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL28 Gene

Proteins for KLHL28 Gene

  • Protein details for KLHL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXS3-KLH28_HUMAN
    Recommended name:
    Kelch-like protein 28
    Protein Accession:
    Q9NXS3
    Secondary Accessions:
    • Q0VAL5

    Protein attributes for KLHL28 Gene

    Size:
    571 amino acids
    Molecular mass:
    64192 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLHL28 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL28 Gene

Post-translational modifications for KLHL28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLHL28 Gene

Domains & Families for KLHL28 Gene

Gene Families for KLHL28 Gene

Suggested Antigen Peptide Sequences for KLHL28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXS3

UniProtKB/Swiss-Prot:

KLH28_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL28: view

Function for KLHL28 Gene

Gene Ontology (GO) - Molecular Function for KLHL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL28: view
genes like me logo Genes that share phenotypes with KLHL28: view

Animal Model Products

miRNA for KLHL28 Gene

miRTarBase miRNAs that target KLHL28

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL28 Gene

Localization for KLHL28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL28 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KLHL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL28: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL28 Gene

Pathways & Interactions for KLHL28 Gene

SuperPathways for KLHL28 Gene

No Data Available

Interacting Proteins for KLHL28 Gene

Gene Ontology (GO) - Biological Process for KLHL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with KLHL28: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL28 Gene

Transcripts for KLHL28 Gene

Unigene Clusters for KLHL28 Gene

Kelch-like family member 28:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL28 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8
SP1: -
SP2:
SP3: - -
SP4:
SP5: - -
SP6: -

Relevant External Links for KLHL28 Gene

GeneLoc Exon Structure for
KLHL28
ECgene alternative splicing isoforms for
KLHL28

Expression for KLHL28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLHL28 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL28 Gene:

KLHL28

SOURCE GeneReport for Unigene cluster for KLHL28 Gene:

Hs.550906
genes like me logo Genes that share expression patterns with KLHL28: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KLHL28 Gene

Orthologs for KLHL28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL28 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia KLHL28 34 35
  • 95.62 (n)
cow
(Bos Taurus)
Mammalia KLHL28 34 35
  • 94.63 (n)
rat
(Rattus norvegicus)
Mammalia Klhl28 34
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Klhl28 34 16 35
  • 91.13 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL28 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL28 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL28 34 35
  • 80.27 (n)
lizard
(Anolis carolinensis)
Reptilia KLHL28 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl28 34
  • 79.16 (n)
zebrafish
(Danio rerio)
Actinopterygii KLHL28 35
  • 82 (a)
OneToOne
klhl28 34
  • 68.88 (n)
Species where no ortholog for KLHL28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL28 Gene

ENSEMBL:
Gene Tree for KLHL28 (if available)
TreeFam:
Gene Tree for KLHL28 (if available)

Paralogs for KLHL28 Gene

Variants for KLHL28 Gene

Sequence variations from dbSNP and Humsavar for KLHL28 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10129201 -- 44,950,969(+) TATGA(A/G)CCATT intron-variant
rs10129456 -- 44,928,404(+) ATCAT(A/G)ATAAT utr-variant-3-prime
rs10131595 -- 44,955,396(+) tagca(A/T)tcaga intron-variant
rs10135494 -- 44,943,825(+) tcctc(C/T)tgcct intron-variant
rs10136741 -- 44,948,303(+) AAAAC(A/G)TGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL28 Gene

Variant ID Type Subtype PubMed ID
dgv1904n100 CNV loss 25217958
nsv1053437 CNV loss 25217958
nsv1259 CNV deletion 18451855
nsv564642 CNV loss 21841781
nsv819173 CNV loss 19587683

Variation tolerance for KLHL28 Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL28 Gene

Disorders for KLHL28 Gene

Relevant External Links for KLHL28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL28

No disorders were found for KLHL28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL28 Gene

Publications for KLHL28 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3 64
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for KLHL28 Gene

Sources for KLHL28 Gene

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