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Aliases for KLHL26 Gene

Aliases for KLHL26 Gene

  • Kelch Like Family Member 26 2 3 5
  • Kelch-Like 26 (Drosophila) 2

External Ids for KLHL26 Gene

Previous GeneCards Identifiers for KLHL26 Gene

  • GC19P018609
  • GC19P018747
  • GC19P018309

Summaries for KLHL26 Gene

GeneCards Summary for KLHL26 Gene

KLHL26 (Kelch Like Family Member 26) is a Protein Coding gene. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL26 Gene

Genomics for KLHL26 Gene

Regulatory Elements for KLHL26 Gene

Enhancers for KLHL26 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL26 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL26 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL26 Gene

18,636,965 bp from pter
18,671,714 bp from pter
34,750 bases
Plus strand

Genomic View for KLHL26 Gene

Genes around KLHL26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL26 Gene

Proteins for KLHL26 Gene

  • Protein details for KLHL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 26
    Protein Accession:
    Secondary Accessions:
    • Q8TAP0
    • Q9NUX3

    Protein attributes for KLHL26 Gene

    615 amino acids
    Molecular mass:
    68139 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL26 Gene

Proteomics data for KLHL26 Gene at MOPED

Post-translational modifications for KLHL26 Gene

  • Ubiquitination at Lys 329, Lys 447, and Lys 491
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL26 Gene

No data available for DME Specific Peptides for KLHL26 Gene

Domains & Families for KLHL26 Gene

Gene Families for KLHL26 Gene

Suggested Antigen Peptide Sequences for KLHL26 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL26: view

Function for KLHL26 Gene

Gene Ontology (GO) - Molecular Function for KLHL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL26: view
genes like me logo Genes that share phenotypes with KLHL26: view

Animal Model Products

miRNA for KLHL26 Gene

miRTarBase miRNAs that target KLHL26

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL26 Gene

Localization for KLHL26 Gene

Subcellular locations from

Jensen Localization Image for KLHL26 Gene COMPARTMENTS Subcellular localization image for KLHL26 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL26 Gene

Pathways & Interactions for KLHL26 Gene

SuperPathways for KLHL26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL26 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHL26 Gene

Drugs & Compounds for KLHL26 Gene

No Compound Related Data Available

Transcripts for KLHL26 Gene

Unigene Clusters for KLHL26 Gene

Kelch-like family member 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL26 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for KLHL26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL26 Gene

mRNA expression in normal human tissues for KLHL26 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL26 Gene

This gene is overexpressed in Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for KLHL26 Gene

This gene is overexpressed in Testis (20.3), Gallbladder (14.2), CD8 Tcells (8.7), Retina (8.3), Colon (8.2), and Fetal ovary (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL26 Gene

SOURCE GeneReport for Unigene cluster for KLHL26 Gene Hs.250632

genes like me logo Genes that share expression patterns with KLHL26: view

Protein tissue co-expression partners for KLHL26 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL26 Gene

Orthologs for KLHL26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL26 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL26 35
  • 90.82 (n)
  • 95.78 (a)
KLHL26 36
  • 94 (a)
(Canis familiaris)
Mammalia KLHL26 35
  • 89.53 (n)
  • 96.79 (a)
KLHL26 36
  • 85 (a)
(Mus musculus)
Mammalia Klhl26 35
  • 83.05 (n)
  • 87.16 (a)
Klhl26 16
Klhl26 36
  • 87 (a)
(Pan troglodytes)
Mammalia KLHL26 35
  • 99.72 (n)
  • 100 (a)
KLHL26 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhl26 35
  • 83.33 (n)
  • 87.33 (a)
(Monodelphis domestica)
Mammalia KLHL26 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL26 36
  • 85 (a)
(Gallus gallus)
Aves KLHL26 35
  • 78.38 (n)
  • 86.69 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl26 35
  • 68.13 (n)
  • 82.57 (a)
(Danio rerio)
Actinopterygii klhl26 35
  • 70.57 (n)
  • 78.44 (a)
wufi20e10 35
klhl26 36
  • 77 (a)
Species with no ortholog for KLHL26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL26 Gene

Gene Tree for KLHL26 (if available)
Gene Tree for KLHL26 (if available)

Paralogs for KLHL26 Gene

genes like me logo Genes that share paralogs with KLHL26: view

Variants for KLHL26 Gene

Sequence variations from dbSNP and Humsavar for KLHL26 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17852384 - 18,669,021(+) CCAGC(A/G/T)TGAGC reference, missense
rs757350 -- 18,664,000(+) CCTCT(A/G)TCTAG intron-variant
rs7259914 -- 18,650,408(+) CCTCT(A/C)TGTTG intron-variant
rs12975964 -- 18,655,163(+) CATCT(A/G)TAGAG intron-variant
rs12976113 -- 18,656,670(+) GCGCA(A/G)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL26 Gene

Variant ID Type Subtype PubMed ID
nsv911281 CNV Loss 21882294
nsv911282 CNV Loss 21882294
nsv833776 CNV Loss 17160897
dgv3784n71 CNV Loss 21882294
esv25959 CNV Loss 19812545
esv24559 CNV Gain 19812545

Variation tolerance for KLHL26 Gene

Residual Variation Intolerance Score: 2.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 27.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLHL26 Gene

Disorders for KLHL26 Gene

Relevant External Links for KLHL26

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL26 Gene

Publications for KLHL26 Gene

  1. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PMID: 22419666) Shi M. … Beaty T.H. (Am. J. Med. Genet. A 2012) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for KLHL26 Gene

Sources for KLHL26 Gene