KLHL26 Gene
protein-coding GIFtS: 45
GCID: GC19P018747
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kelch-like family member 26(Previous name: kelch-like 26 (Drosophila) )
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Aliases
for KLHL26 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 261 2 | | Kelch-Like 26 (Drosophila)1 | | Kelch-Like 262 | | Kelch-Like Protein 262 |
Export aliases for KLHL26 gene to outside databasesPrevious GC identifers: GC19P018609 GC19P018309 |
Summaries
for KLHL26 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLHL26 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL26 gene promoter:
FOXF2 Pax-5 GCNF AP-4 E47 GCNF-1 Hand1 Pax-4a GCNF-2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL26
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL26 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11KLHL26 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P018747: view genomic region
(about GC identifiers)
Start:
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18,747,838 bp from pter |
End:
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18,781,302 bp from pter |
Size:
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33,465 bases |
Orientation:
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plus strand |
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Proteins
for KLHL26 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLH26_HUMAN, Q53HC5 (See
protein sequence)Recommended Name: Kelch-like protein 26 Size: 615 amino acids; 68139 Da
Secondary accessions: Q8TAP0 Q9NUX3Explore the universe of human proteins at neXtProt for KLHL26: NX_Q53HC5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q53HC5
KLHL26 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060786.1
ENSEMBL proteins: ENSP00000300976
Human Recombinant Protein Products:
KLHL26 Antibody Products:
Assay Products for KLHL26: |
Protein
Domains /
Families
for KLHL26 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHL26 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q53HC5ProtoNet protein and cluster: Q53HC5 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KLH26_HUMAN, Q53HC5Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats |
Function
for KLHL26 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL26 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL26
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for KLHL26 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL26 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL26 |
1 GenomeRNAi human phenotype for KLHL26:
|
Pathways & Interactions
for KLHL26 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL26
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for KLHL26 (Q53HC52, 3 ENSP000003009764) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for KLHL26 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL26
Search CenterWatch for drugs/clinical trials and news about KLHL26 / KLH26
|
Transcripts
for KLHL26 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL26 gene: NM_018316.1 Unigene Cluster for KLHL26: Kelch-like 26 (Drosophila) Hs.250632 [show with all ESTs]Unigene Representative Sequence: BC0263191 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000300976(uc002njz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL26 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL26
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHL26 (NM_018316) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL26 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL26 |
Additional cDNA sequence: AK001940.1 AK222656.1 AK294074.1 BC026319.1 3 DOTS entries: DT.112160 DT.100022698 DT.100008761 24/105 AceView cDNA sequences (see all 105): CK825077 BM831331 BQ648889 BQ064469 BU850078 AA295803 NM_018316 BU620854 BM930972 BU552943 CB070344 AI741755 BQ071358 BF001374 BM830636 N47890 AA806614 AK001940 AI796101 BM834801 BM272514 BC026319 BG683339 BG682779
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL26 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
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| SP1: | | | | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | | | | | | |
ECgene alternative splicing isoforms for KLHL26
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Expression
for KLHL26 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAGAATTA
About this image
See KLHL26 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL26
SOURCE GeneReport for Unigene cluster: Hs.250632
SABiosciences Custom PCR Arrays for KLHL26
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL26
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL26 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL26 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL26 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL26 |
Orthologs
for KLHL26 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KLHL26 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for KLHL26 (if available)
TreeFam Gene Tree for KLHL26 (if available) |
Paralogs
for KLHL26 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL26 gene
- KLHL422 KLHL132 KLHL222 KLHL342 KBTBD132 KBTBD112 KLHL312 KLHL92
- KLHL322 KLHL142 KLHDC7B2 KLHL152 KLHL362 KLHL332 KLHDC7A2
17 SIMAP similar genes for KLHL26 using alignment to 5 protein entries: KLH26_HUMAN (see all proteins):DKFZp686L0695 KLHL13 KLHL9 KBTBD3 KLHL31 KLHL36
KLHL22 KLHL18 KLHL4 KLHL5 KLHL1 KLHL15
KLHL2 KLHL20 KLHL3 KLHL32 KLHL14
KLHL26 for paralogs About GeneDecksing
|
Genomic Variants
for KLHL26 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHL26 (18747838 - 18781302 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KLHL26
2 CNVs: 73324 73323 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL26 |
|
Disorders
/ Diseases
for KLHL26 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLHL26 for disorders About GeneDecksing
1  disease for KLHL26: About MalaCardsataxia
Export disorders for KLHL26 gene to outside databases
|
Publications
for KLHL26 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL26 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with KLHL26) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Genome wide study of maternal and parent-of-origin eff ects on the etiology of orofacial clefts. (PubMed id 22419666)1 Shi M....Beaty T.H. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
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External Searches for KLHL26 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KLHL26 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL26 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHL26 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL26 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for KLHL26 gene:
Search GeneIP for patents involving KLHL26
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL26 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLHL26 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL26 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL26 | | | OriGene Protein Over-expression Lysate for KLHL26 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLHL26 | | OriGene 3'-UTR Clone for KLHL26 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL26 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL26 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | KLHL26 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL26 |
|  |  |  | | | | Search ThermoFisher Antibodies for KLHL26 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL26 |
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