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KLHL26 Gene

protein-coding   GIFtS: 49
GCID: GC19P018747

Kelch-Like Family Member 26

(Previous name: kelch-like 26 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 261 2
Kelch-Like 26 (Drosophila)1
Kelch-Like 262
Kelch-Like Protein 262

External Ids:    HGNC: 256231   Entrez Gene: 552952   Ensembl: ENSG000001674877   UniProtKB: Q53HC53   

Export aliases for KLHL26 gene to outside databases

Previous GC identifers: GC19P018609 GC19P018309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL26 Gene:
KLHL26 (kelch-like family member 26) is a protein-coding gene. An important paralog of this gene is KLHL42.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL26 gene promoter:
         FOXF2   Pax-5   GCNF   AP-4   E47   GCNF-1   Hand1   Pax-4a   GCNF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL26 promoter sequence
   Search Chromatin IP Primers for KLHL26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

KLHL26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL26 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P018747:  view genomic region     (about GC identifiers)

Start:
18,747,775 bp from pter      End:
18,781,309 bp from pter
Size:
33,535 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLH26_HUMAN, Q53HC5 (See protein sequence)
Recommended Name: Kelch-like protein 26  
Size: 615 amino acids; 68139 Da
Secondary accessions: Q8TAP0 Q9NUX3

Explore the universe of human proteins at neXtProt for KLHL26: NX_Q53HC5

Explore proteomics data for KLHL26 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys329, Lys447, Lys491
  • Modification sites at PhosphoSitePlus

  • See KLHL26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060786.1  
    ENSEMBL proteins: 
     ENSP00000300976   ENSP00000472032   ENSP00000470999   ENSP00000472001   ENSP00000469099  

    KLHL26 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for KLHL26 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q53HC5

    ProtoNet protein and cluster: Q53HC5

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH26_HUMAN, Q53HC5
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Find genes that share domains with KLHL26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KLHL26           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL26:
     Increased cell death in DLD-1  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL26
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    5 qRT-PCR Assays for microRNAs that regulate KLHL26:
    hsa-miR-374b* hsa-miR-4254 hsa-miR-129-3p hsa-miR-129* hsa-miR-3126-5p
    SwitchGear 3'UTR luciferase reporter plasmidKLHL26 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLHL26

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL26


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL26
    Interactions:

        Search GeneGlobe Interaction Network for KLHL26

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KLHL26 (Q53HC52, 3 ENSP000003009764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBQLN4Q9NRR52, 3, ENSP000003572924MINT-2874293 I2D: score=3 STRING: ENSP00000357292
    ACIN1Q9UKV32, 3, ENSP000002627104MINT-65639 I2D: score=4 STRING: ENSP00000262710
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL26 (KLH26)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLHL26 gene: 
    NM_018316.1  

    Unigene Cluster for KLHL26:

    Kelch-like family member 26
    Hs.250632  [show with all ESTs]
    Unigene Representative Sequence: BC026319
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300976(uc002njz.1) ENST00000595182 ENST00000600657 ENST00000599006
    ENST00000595423 ENST00000596843
    miRNA
    Products:
         
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    5 qRT-PCR Assays for microRNAs that regulate KLHL26:
    hsa-miR-374b* hsa-miR-4254 hsa-miR-129-3p hsa-miR-129* hsa-miR-3126-5p
    SwitchGear 3'UTR luciferase reporter plasmidKLHL26 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLHL26
    Clone
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    GenScript: all cDNA clones in your preferred vector: KLHL26 (NM_018316)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL26
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL26
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL26
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL26
      QuantiTect SYBR Green Assays in human, mouse, rat KLHL26
      QuantiFast Probe-based Assays in human, mouse, rat KLHL26

    Additional mRNA sequence: 

    AK001940.1 AK222656.1 AK294074.1 BC026319.1 

    3 DOTS entries:

    DT.112160  DT.100022698  DT.100008761 

    Selected AceView cDNA sequences (see all 105):

    CB070344 BU620854 BM830636 N47890 BU850078 AI796101 BM930972 BF001374 
    BM831331 BQ071358 CK825077 NM_018316 AA806614 AK001940 BQ064469 BQ648889 
    BU552943 AA295803 AI741755 BU074530 BU553994 AW511593 BI547987 BU846487 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL26    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                                -     -               
    SP2:                    -           -     -               
    SP3:                    -                                 
    SP4:                    -           -                     


    ECgene alternative splicing isoforms for KLHL26

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAAGAATTA
    KLHL26 Expression
    About this image

    KLHL26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250632
        Custom PCR Arrays for KLHL26
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL26

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL26 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl261 , 5 kelch-like 26 (Drosophila)5
    kelch-like 261
    83.05(n)1
    87.16(a)1
      8 (34.15 cM)5
    2343781  NM_178771.31  NP_848886.11 
     704502285 
    chicken
    (Gallus gallus)
    Aves KLHL261 kelch-like 26 (Drosophila) 78.38(n)
    86.69(a)
      420121  XM_004948904.1  XP_004948961.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    30(a)
    many ↔ many
    GL343498.1(170741-173027)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klhl261 kelch-like family member 26 68.13(n)
    82.57(a)
      100494192  XM_004915481.1  XP_004915538.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi20e102 wufi20e10 78.03(n)   327621  CF348269.1 


    ENSEMBL Gene Tree for KLHL26 (if available)
    TreeFam Gene Tree for KLHL26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL26 gene
    KLHL422  KLHL132  KLHL222  KLHL342  KLHL312  KBTBD132  KBTBD112  KLHL322  
    KLHL92  KLHL142  KLHL152  KLHL362  KLHDC7B2  KLHL332  KLHDC7A2  
    Selected SIMAP similar genes for KLHL26 using alignment to 5 protein entries:     KLH26_HUMAN (see all proteins) (see all similar genes):
    BTBD9    KLHL24    ZBTB7C    DKFZp686L0695    KLHL13    KLHL36
    KLHL9    KLHL22    ZBTB44    KLHL28    KBTBD3    Bach2
    KBTBD4    KLHL10    KLHL31    ZBTB49    BACH2    ZBTB21

    Find genes that share paralogs with KLHL26           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL26 (see all 706)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459237901,2
    C--18745938(+) CAAGG-/GTGTGTG 1 -- us2k10--------
    rs612768341,2
    C--18745939(+) GTGTG-/GT/TG 
            
    CAGAG
    1 -- us2k10--------
    rs1496480891,2
    --18745988(+) ATGCAC/TGCGTG 1 -- us2k10--------
    rs1819237211,2
    --18746022(+) ACTGTA/GTATTG 1 -- us2k10--------
    rs1443897121,2
    --18746054(+) AGCACC/TTGGTA 1 -- us2k10--------
    rs1147243451,2
    C,F--18746102(+) TGTAAC/TGATTG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1858974321,2
    --18746143(+) GGAGAA/TGCTGG 1 -- us2k10--------
    rs762604731,2
    C,F--18746248(+) ACTGAC/TGGGAA 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1904536071,2
    --18746295(+) GCCCAA/GGACTG 1 -- us2k10--------
    rs1826922701,2
    --18746385(+) GCTTAC/TCAGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLHL26 (18747775 - 18781309 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KLHL26:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833776CNV Loss17160897
    esv25959CNV Loss19812545
    dgv3784n71CNV Loss21882294
    nsv911282CNV Loss21882294
    nsv911281CNV Loss21882294
    esv24559CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL26
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with KLHL26           About GenesLikeMe

    Genetic Association Database (GAD): KLHL26

    Export disorders for KLHL26 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL26 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with KLHL26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PubMed id 22419666)1, 4 Shi M....Beaty T.H. (Am. J. Med. Genet. A 2012)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55295 HGNC: 25623 AceView: FLJ11078 Ensembl:ENSG00000167487 euGenes: HUgn55295
    ECgene: KLHL26 H-InvDB: KLHL26

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLHL26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KLHL26 gene:
    Search GeneIP for patents involving KLHL26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Search Addgene for plasmids for KLHL26
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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