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Aliases for KLHL26 Gene

Aliases for KLHL26 Gene

  • Kelch-Like Family Member 26 2 3
  • Kelch-Like 26 (Drosophila) 2

External Ids for KLHL26 Gene

Previous GeneCards Identifiers for KLHL26 Gene

  • GC19P018609
  • GC19P018747
  • GC19P018309

Summaries for KLHL26 Gene

GeneCards Summary for KLHL26 Gene

KLHL26 (Kelch-Like Family Member 26) is a Protein Coding gene. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL26 Gene

Genomics for KLHL26 Gene

Regulatory Elements for KLHL26 Gene

Genomic Location for KLHL26 Gene

18,636,965 bp from pter
18,671,714 bp from pter
34,750 bases
Plus strand

Genomic View for KLHL26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL26 Gene

Proteins for KLHL26 Gene

  • Protein details for KLHL26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 26
    Protein Accession:
    Secondary Accessions:
    • Q8TAP0
    • Q9NUX3

    Protein attributes for KLHL26 Gene

    615 amino acids
    Molecular mass:
    68139 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHL26 Gene

Proteomics data for KLHL26 Gene at MOPED

Post-translational modifications for KLHL26 Gene

  • Ubiquitination at Lys329, Lys447, and Lys491
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL26 Gene

Antibody Products

No data available for DME Specific Peptides for KLHL26 Gene

Domains for KLHL26 Gene

Gene Families for KLHL26 Gene

  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL26 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q53HC5
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL26: view

Function for KLHL26 Gene

Gene Ontology (GO) - Molecular Function for KLHL26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL26: view

Phenotypes for KLHL26 Gene

GenomeRNAi human phenotypes for KLHL26:
genes like me logo Genes that share phenotypes with KLHL26: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL26

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLHL26 Gene

Localization for KLHL26 Gene

Subcellular locations from

Jensen Localization Image for KLHL26 Gene COMPARTMENTS Subcellular localization image for KLHL26 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL26 Gene

Pathways for KLHL26 Gene

SuperPathways for KLHL26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL26 Gene


No data available for Pathways by source for KLHL26 Gene

Transcripts for KLHL26 Gene

mRNA/cDNA for KLHL26 Gene

Unigene Clusters for KLHL26 Gene

Kelch-like family member 26:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL26

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL26 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for KLHL26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL26 Gene

mRNA expression in normal human tissues for KLHL26 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL26 Gene

This gene is overexpressed in Artery - Tibial (4.0).

Protein differential expression in normal tissues for KLHL26 Gene

This gene is overexpressed in Testis (20.3), Gallbladder (14.2), CD8 Tcells (8.7), Retina (8.3), Colon (8.2), and Fetal ovary (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL26 Gene

SOURCE GeneReport for Unigene cluster for KLHL26 Gene Hs.250632

genes like me logo Genes that share expressions with KLHL26: view

Expression partners for KLHL26 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL26 Gene

Orthologs for KLHL26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL26 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL26 35
  • 90.82 (n)
  • 95.78 (a)
KLHL26 36
  • 94 (a)
(Canis familiaris)
Mammalia KLHL26 35
  • 89.53 (n)
  • 96.79 (a)
KLHL26 36
  • 85 (a)
(Mus musculus)
Mammalia Klhl26 35
  • 83.05 (n)
  • 87.16 (a)
Klhl26 16
Klhl26 36
  • 87 (a)
(Pan troglodytes)
Mammalia KLHL26 35
  • 99.72 (n)
  • 100 (a)
KLHL26 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhl26 35
  • 83.33 (n)
  • 87.33 (a)
(Monodelphis domestica)
Mammalia KLHL26 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL26 36
  • 85 (a)
(Gallus gallus)
Aves KLHL26 35
  • 78.38 (n)
  • 86.69 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl26 35
  • 68.13 (n)
  • 82.57 (a)
(Danio rerio)
Actinopterygii klhl26 35
  • 70.57 (n)
  • 78.44 (a)
wufi20e10 35
klhl26 36
  • 77 (a)
Species with no ortholog for KLHL26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL26 Gene

Gene Tree for KLHL26 (if available)
Gene Tree for KLHL26 (if available)

Paralogs for KLHL26 Gene

genes like me logo Genes that share paralogs with KLHL26: view

Variants for KLHL26 Gene

Sequence variations from dbSNP and Humsavar for KLHL26 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3220 -- 18,670,383(-) CAATC(A/G)TCTGT utr-variant-3-prime
rs733715 -- 18,651,898(-) TCCCC(C/G)GACTT intron-variant
rs739852 -- 18,663,891(+) CGTGT(A/G)TCCTT intron-variant
rs752981 -- 18,663,980(+) ACAGT(G/T)GTATG intron-variant
rs754245 -- 18,649,757(+) TTCCT(A/G)CCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL26 Gene

Variant ID Type Subtype PubMed ID
nsv911281 CNV Loss 21882294
nsv911282 CNV Loss 21882294
nsv833776 CNV Loss 17160897
dgv3784n71 CNV Loss 21882294
esv25959 CNV Loss 19812545
esv24559 CNV Gain 19812545

Relevant External Links for KLHL26 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL26 Gene

Disorders for KLHL26 Gene

Relevant External Links for KLHL26

Genetic Association Database (GAD)

No disorders were found for KLHL26 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KLHL26 Gene

Publications for KLHL26 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. (PMID: 22419666) Shi M. … Beaty T.H. (Am. J. Med. Genet. A 2012) 3 48
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KLHL26 Gene

Sources for KLHL26 Gene

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