Aliases for KLHL25 Gene
External Ids for KLHL25 Gene
GeneCards Summary for KLHL25 Gene
KLHL25 (Kelch-Like Family Member 25) is a Protein Coding gene. An important paralog of this gene is KBTBD6.
UniProtKB/Swiss-Prot for KLHL25 Gene
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.