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Aliases for KLHL25 Gene

Aliases for KLHL25 Gene

  • Kelch-Like Family Member 25 2 3
  • Ectoderm-Neural Cortex Protein 2 3 4
  • Ectodermal-Neural Cortex 2 2 3
  • ENC-2 3 4
  • ENC2 3 4
  • BTB/POZ KELCH Domain Protein 3
  • Kelch-Like 25 (Drosophila) 2
  • Kelch-Like Protein 25 3
  • Kelch-Like 25 3

External Ids for KLHL25 Gene

Summaries for KLHL25 Gene

GeneCards Summary for KLHL25 Gene

KLHL25 (Kelch-Like Family Member 25) is a Protein Coding gene. An important paralog of this gene is KBTBD6.

UniProtKB/Swiss-Prot for KLHL25 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Gene Wiki entry for KLHL25 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL25 Gene

Genomics for KLHL25 Gene

Genomic Location for KLHL25 Gene

Start:
85,759,323 bp from pter
End:
85,795,030 bp from pter
Size:
35,708 bases
Orientation:
Minus strand

Genomic View for KLHL25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL25 Gene

Regulatory Elements for KLHL25 Gene

Proteins for KLHL25 Gene

  • Protein details for KLHL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0H3-KLH25_HUMAN
    Recommended name:
    Kelch-like protein 25
    Protein Accession:
    Q9H0H3
    Secondary Accessions:
    • B2RDH2
    • B3KRT7

    Protein attributes for KLHL25 Gene

    Size:
    589 amino acids
    Molecular mass:
    65923 Da
    Quaternary structure:
    • Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. Interacts with EIF4EBP1 (when hypophosphorylated).

neXtProt entry for KLHL25 Gene

Proteomics data for KLHL25 Gene at MOPED

Post-translational modifications for KLHL25 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys263

Other Protein References for KLHL25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL25 Gene

Domains for KLHL25 Gene

Gene Families for KLHL25 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

UniProtKB/Swiss-Prot:

KLH25_HUMAN
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.:
    • Q9H0H3
  • Contains 1 BTB (POZ) domain.:
    • Q9H0H3
Similarity:
  • Contains 6 Kelch repeats.:
    • Q9H0H3
genes like me logo Genes that share domains with KLHL25: view

Function for KLHL25 Gene

Molecular function for KLHL25 Gene

UniProtKB/Swiss-Prot Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Gene Ontology (GO) - Molecular Function for KLHL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL25: view

Phenotypes for KLHL25 Gene

GenomeRNAi human phenotypes for KLHL25:
genes like me logo Genes that share phenotypes with KLHL25: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLHL25 Gene

Localization for KLHL25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL25 Gene COMPARTMENTS Subcellular localization image for KLHL25 gene
Compartment Confidence
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for KLHL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 22578813
genes like me logo Genes that share ontologies with KLHL25: view

Pathways for KLHL25 Gene

SuperPathways for KLHL25 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H0H3-KLH25_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for KLHL25 Gene

Gene Ontology (GO) - Biological Process for KLHL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006446 regulation of translational initiation IDA 22578813
GO:0016567 protein ubiquitination IDA 22578813
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 22578813
genes like me logo Genes that share ontologies with KLHL25: view

No data available for Pathways by source for KLHL25 Gene

Transcripts for KLHL25 Gene

mRNA/cDNA for KLHL25 Gene

Unigene Clusters for KLHL25 Gene

Kelch-like family member 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL25 Gene

No ASD Table

Relevant External Links for KLHL25 Gene

GeneLoc Exon Structure for
KLHL25
ECgene alternative splicing isoforms for
KLHL25

Expression for KLHL25 Gene

mRNA expression in normal human tissues for KLHL25 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL25 Gene

SOURCE GeneReport for Unigene cluster for KLHL25 Gene Hs.498371

genes like me logo Genes that share expressions with KLHL25: view

Orthologs for KLHL25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL25 36
  • 99.38 (n)
  • 99.83 (a)
KLHL25 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHL25 36
  • 88.79 (n)
  • 95.59 (a)
KLHL25 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL25 36
  • 91.4 (n)
  • 97.79 (a)
KLHL25 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl25 36
  • 87.72 (n)
  • 94.91 (a)
Klhl25 16
Klhl25 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL25 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL25 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl25 36
  • 87.66 (n)
  • 94.74 (a)
chicken
(Gallus gallus)
Aves KLHL25 36
  • 80.48 (n)
  • 90.15 (a)
KLHL25 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL25 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl25 36
  • 72.72 (n)
  • 85.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6382 36
zebrafish
(Danio rerio)
Actinopterygii enc3 37
  • 72 (a)
ManyToMany
si:ch211-256e16.3 37
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToMany
Species with no ortholog for KLHL25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL25 Gene

ENSEMBL:
Gene Tree for KLHL25 (if available)
TreeFam:
Gene Tree for KLHL25 (if available)

Paralogs for KLHL25 Gene

Selected SIMAP similar genes for KLHL25 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KLHL25 Gene

genes like me logo Genes that share paralogs with KLHL25: view

Variants for KLHL25 Gene

Sequence variations from dbSNP and Humsavar for KLHL25 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs888370 -- 85,781,106(-) ccacc(C/T)acctt intron-variant, upstream-variant-2KB
rs1138052 -- 85,787,996(-) ccaca(A/G)cctct intron-variant
rs1978391 -- 85,768,464(-) GTTTT(C/T)GGAGG reference, synonymous-codon
rs2248675 -- 85,775,555(+) CAGGA(C/G)TTCCA intron-variant
rs2252527 -- 85,784,813(+) ACTTG(G/T)GAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL25 Gene

Variant ID Type Subtype PubMed ID
nsv516322 CNV Loss 19592680
nsv904464 CNV Loss 21882294
nsv471258 CNV Loss 18288195

Relevant External Links for KLHL25 Gene

HapMap Linkage Disequilibrium report
KLHL25

Disorders for KLHL25 Gene

Relevant External Links for KLHL25

Genetic Association Database (GAD)
KLHL25
genes like me logo Genes that share disorders with KLHL25: view

No data available for UniProtKB/Swiss-Prot for KLHL25 Gene

Publications for KLHL25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 3 49
  5. Translational homeostasis via the mRNA cap-binding protein, eIF4E. (PMID: 22578813) Yanagiya A. … Sonenberg N. (Mol. Cell 2012) 3 4

Products for KLHL25 Gene

Sources for KLHL25 Gene

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