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KLHL25 Gene

protein-coding   GIFtS: 48
GCID: GC15M086302

Kelch-Like Family Member 25

(Previous name: kelch-like 25 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 251 2     Kelch-Like 25 (Drosophila)1
Ectodermal-Neural Cortex 21 2     BTB/POZ KELCH Domain Protein2
Ectoderm-Neural Cortex Protein 22 3     Kelch-Like 252
ENC-22 3     Kelch-Like Protein 252
ENC22 3     

External Ids:    HGNC: 257321   Entrez Gene: 644102   Ensembl: ENSG000001836557   UniProtKB: Q9H0H33   

Export aliases for KLHL25 gene to outside databases

Previous GC identifers: GC15M084105 GC15M062365


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL25 Gene:
KLHL25 (kelch-like family member 25) is a protein-coding gene. An important paralog of this gene is KLHL21.

UniProtKB/Swiss-Prot: KLH25_HUMAN, Q9H0H3
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for
translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of
hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1
(4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when
eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or
associated with eIF4E

Gene Wiki entry for KLHL25 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL25 gene promoter:
         Sp1   Pbx1a   AML1a   POU6F1 (c2)   Gfi-1   S8   SRY   HFH-1   ARP-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL25 promoter sequence
   Search Chromatin IP Primers for KLHL25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.3   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q25.3

KLHL25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL25 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M086302:  view genomic region     (about GC identifiers)

Start:
86,302,554 bp from pter      End:
86,338,261 bp from pter
Size:
35,708 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLH25_HUMAN, Q9H0H3 (See protein sequence)
Recommended Name: Kelch-like protein 25  
Size: 589 amino acids; 65923 Da
Subunit: Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1.
Interacts with EIF4EBP1 (when hypophosphorylated)
Secondary accessions: B2RDH2 B3KRT7

Explore the universe of human proteins at neXtProt for KLHL25: NX_Q9H0H3

Explore proteomics data for KLHL25 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys263
  • Modification sites at PhosphoSitePlus

  • See KLHL25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071925.2  
    ENSEMBL proteins: 
     ENSP00000336800   ENSP00000444739  

    KLHL25 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KLHL25 

     
    antibodies-online proteins for KLHL25 (5 products) 

     
    antibodies-online peptides for KLHL25

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR013069 BTB_POZ
     IPR011705 BACK

    Graphical View of Domain Structure for InterPro Entry Q9H0H3

    ProtoNet protein and cluster: Q9H0H3

    1 Blocks protein domain: IPB011705 BTB/Kelch-associated

    UniProtKB/Swiss-Prot: KLH25_HUMAN, Q9H0H3
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Find genes that share domains with KLHL25           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH25_HUMAN, Q9H0H3
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for
    translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of
    hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1
    (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when
    eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or
    associated with eIF4E

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KLHL25           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL25:
     Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KLHL25

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    SwitchGear 3'UTR luciferase reporter plasmidKLHL25 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0031463Cul3-RING ubiquitin ligase complex IDA--

    Find genes that share ontologies with KLHL25           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: KLH25_HUMAN, Q9H0H3
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL25
    Interactions:

        Search GeneGlobe Interaction Network for KLHL25

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for KLHL25 (ENSP000003368004) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL3ENSP000002644144STRING: ENSP00000264414
    EIF4EBP1ENSP000003406914STRING: ENSP00000340691
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006446regulation of translational initiation IDA--
    GO:0016567protein ubiquitination IDA--
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA--

    Find genes that share ontologies with KLHL25           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL25 (KLH25)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLHL25 gene: 
    NM_022480.3  

    Unigene Cluster for KLHL25:

    Kelch-like family member 25
    Hs.498371  [show with all ESTs]
    Unigene Representative Sequence: NM_022480
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337975(uc002bly.3) ENST00000559131 ENST00000536947
    miRNA
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    hsa-miR-29c hsa-miR-29a hsa-miR-3652 hsa-miR-764 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidKLHL25 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat KLHL25
      QuantiFast Probe-based Assays in human, mouse, rat KLHL25

    Additional mRNA sequence: 

    AK022649.1 AK056663.1 AK092231.1 AK315541.1 AL109693.1 AY764034.1 

    7 DOTS entries:

    DT.100749600  DT.208771  DT.100749596  DT.100749595  DT.95324844  DT.100756376  DT.102826444 

    Selected AceView cDNA sequences (see all 73):

    BI789221 AL109693 T08897 NM_022480 AI937771 CB049579 BU168436 BC028100 
    AI810324 BM926999 AL136796 AI500269 BU181004 BQ707818 AI929723 CD674605 
    AI815612 BF793506 BG222381 AA312668 BI789083 BM471571 AA904509 AK056663 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL25 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTTTCCC
    KLHL25 Expression
    About this image

    KLHL25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.498371
        Custom PCR Arrays for KLHL25
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL25 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl251 , 5 kelch-like 25 (Drosophila)5
    kelch-like 251
    87.72(n)1
    94.91(a)1
      7 (43.81 cM)5
    2079521  NM_001122780.11  NP_001116252.11 
     758483385 
    chicken
    (Gallus gallus)
    Aves KLHL251 kelch-like 25 (Drosophila) 80.48(n)
    90.15(a)
      770701  XM_004943856.1  XP_004943913.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL256
    kelch-like family member 25
    88(a)
    1 ↔ 1
    GL343922.1(100600-102369)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klhl251 kelch-like family member 25 72.72(n)
    85.06(a)
      779996  NM_001079073.1  NP_001072541.1 
    zebrafish
    (Danio rerio)
    Actinopterygii enc36
    si:ch211-256e16.36
    si:ch211-256e16.3
    72(a)
    28(a)
    many ↔ many
    many ↔ many
    22(10892044-10906103) ENSDARG00000058322
    3(59001028-59022290) ENSDARG00000052426


    ENSEMBL Gene Tree for KLHL25 (if available)
    TreeFam Gene Tree for KLHL25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL25 gene
    KLHL212  KLHL62  KBTBD82  KLHL412  KBTBD122  KBTBD22  KLHL242  ENC12  
    KLHL382  KLHL292  KBTBD32  KLHL232  KLHL402  KBTBD72  KLHL302  KBTBD62  
    KLHL352  
    Selected SIMAP similar genes for KLHL25 using alignment to 1 protein entry:     KLH25_HUMAN(see all similar genes):
    ENC1    KBTBD3    KLHL20    KLHL29    KLHL5    KLHL12
    KLHL17    KLHL23    KLHL3    KLHL2    KLHL30    KLHL38
    KLHL4    KEAP1    KLHL1    KLHL18    KLHL21    KLHL24

    Find genes that share paralogs with KLHL25           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KLHL25
    PGOHUM00000237566


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL25 (see all 927)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105353281,2
    C,F--62382204(+) CGTTT-/A/A   
       A
    /AAA
    aaaaa
    1 -- int12NA 4
    rs1500542601,2
    --86302112(+) TAGCCC/TAGGGC 1 -- ds50010--------
    rs1466400431,2
    --86302115(+) CCCAGA/GGCCCA 1 -- ds50010--------
    rs1902409341,2
    --86302159(+) CTGGCA/GCTGCG 1 -- ds50010--------
    rs1144063271,2
    F--86302208(+) AATGGC/TGCTCG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs8883681,2
    C,F,A--86302283(+) TCCCAA/GCTTCT 1 -- ds50019Minor allele frequency- G:0.30NA WA EA 370
    rs1411734911,2
    C--86302309(+) CAGGAC/GAGAAT 1 -- ds50010--------
    rs1928177241,2
    --86302353(+) TCCACA/GGAATC 1 -- ds50010--------
    rs1857417541,2
    --86302548(+) AGGCAA/GGCAAA 1 -- ds50010--------
    rs25541,2
    C,F,H--86302643(-) ATCACA/GTAGCA 1 -- ut31 ese318Minor allele frequency- G:0.13NA NS EA WA 2094

    HapMap Linkage Disequilibrium report for KLHL25 (86302554 - 86338261 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLHL25:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471258CNV Loss18288195
    nsv516322CNV Loss19592680
    nsv904464CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with KLHL25           About GenesLikeMe

    Genetic Association Database (GAD): KLHL25

    Export disorders for KLHL25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL25 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with KLHL25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Translational homeostasis via the mRNA cap-binding protein, eIF4E. (PubMed id 22578813)1, 2 Yanagiya A....Sonenberg N. (Mol. Cell 2012)
    2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PubMed id 17903295)1, 4 Lunetta K.L....Murabito J.M. (BMC Med. Genet. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. (PubMed id 24025145)1 Chung S....Nakamura Y. (Breast Cancer Res. 2013)
    7. Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. (PubMed id 23594818)1 Ikeda M....Iwata N. (Neuropsychopharmacology 2013)
    8. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64410 HGNC: 25732 AceView: FLJ12587 Ensembl:ENSG00000183655 euGenes: HUgn64410
    ECgene: KLHL25 H-InvDB: KLHL25

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLHL25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL25 gene:
    Search GeneIP for patents involving KLHL25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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