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Aliases for KLHL25 Gene

Aliases for KLHL25 Gene

  • Kelch Like Family Member 25 2 3 5
  • Ectoderm-Neural Cortex Protein 2 3 4
  • Ectodermal-Neural Cortex 2 2 3
  • ENC-2 3 4
  • ENC2 3 4
  • BTB/POZ KELCH Domain Protein 3
  • Kelch-Like 25 (Drosophila) 2
  • Kelch-Like Protein 25 3
  • Kelch-Like 25 3

External Ids for KLHL25 Gene

Previous GeneCards Identifiers for KLHL25 Gene

  • GC15M084105
  • GC15M086302
  • GC15M062365
  • GC15M085771
  • GC15M085783
  • GC15M085797
  • GC15M085816
  • GC15M085826

Summaries for KLHL25 Gene

GeneCards Summary for KLHL25 Gene

KLHL25 (Kelch Like Family Member 25) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ENC1.

UniProtKB/Swiss-Prot for KLHL25 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Gene Wiki entry for KLHL25 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL25 Gene

Genomics for KLHL25 Gene

Regulatory Elements for KLHL25 Gene

Enhancers for KLHL25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G085836 1.3 Ensembl ENCODE 23.7 -43.7 -43679 4.6 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 KLHL25 MIR1276 LOC105370952 ENSG00000259608
GH15G085824 0.6 ENCODE 17.8 -30.2 -30245 0.8 ZNF217 SREBF1 ZNF10 ZHX2 MNT ZBTB40 KLHL25 ENSG00000259407 RNU6-231P MIR548AP
GH15G085701 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +89.6 89593 8.7 HDGF PKNOX1 ATF1 FOXA2 MLX WRNIP1 ARID4B ZNF48 YY1 GATA2 ENSG00000259276 RNU6-1280P RNU6-231P ENSG00000259407 AKAP13 ENSG00000259762 KLHL25 ENSG00000259453 ENSG00000259544
GH15G085825 0.8 ENCODE 11.5 -30.8 -30815 0.0 PKNOX1 SIN3A RAD21 CTBP1 GATA3 RCOR1 ZNF687 MAZ ZNF10 ZHX2 KLHL25 MIR548AP LOC105370952
GH15G085768 0.7 dbSUPER 11.8 +25.4 25375 2.2 MAFG MAX FOXA1 YY1 JUND SMARCA4 ATF3 HNF4G NFE2 HNF4A ENSG00000259276 KLHL25 LOC101929679 ENSG00000259407 MIR1276
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL25 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080611 430 1601 PKNOX1 ARID4B SIN3A ZBTB7B YY1 GLIS2 ZNF143 FOS ZNF263 SP3

Genomic Location for KLHL25 Gene

Chromosome:
15
Start:
85,759,323 bp from pter
End:
85,795,030 bp from pter
Size:
35,708 bases
Orientation:
Minus strand

Genomic View for KLHL25 Gene

Genes around KLHL25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL25 Gene

Proteins for KLHL25 Gene

  • Protein details for KLHL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0H3-KLH25_HUMAN
    Recommended name:
    Kelch-like protein 25
    Protein Accession:
    Q9H0H3
    Secondary Accessions:
    • B2RDH2
    • B3KRT7

    Protein attributes for KLHL25 Gene

    Size:
    589 amino acids
    Molecular mass:
    65923 Da
    Quaternary structure:
    • Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. Interacts with EIF4EBP1 (when hypophosphorylated).

neXtProt entry for KLHL25 Gene

Post-translational modifications for KLHL25 Gene

  • Ubiquitination at posLast=263263
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL25 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KLHL25
  • Santa Cruz Biotechnology (SCBT) Antibodies for KLHL25

No data available for DME Specific Peptides for KLHL25 Gene

Domains & Families for KLHL25 Gene

Gene Families for KLHL25 Gene

Suggested Antigen Peptide Sequences for KLHL25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL25: view

No data available for UniProtKB/Swiss-Prot for KLHL25 Gene

Function for KLHL25 Gene

Molecular function for KLHL25 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Phenotypes for KLHL25 Gene

genes like me logo Genes that share phenotypes with KLHL25: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL25 Gene

Localization for KLHL25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL25 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for KLHL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 22578813
genes like me logo Genes that share ontologies with KLHL25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL25 Gene

Pathways & Interactions for KLHL25 Gene

genes like me logo Genes that share pathways with KLHL25: view

UniProtKB/Swiss-Prot Q9H0H3-KLH25_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KLHL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006446 regulation of translational initiation IDA 22578813
GO:0016567 protein ubiquitination IDA 22578813
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 22578813
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with KLHL25: view

No data available for SIGNOR curated interactions for KLHL25 Gene

Transcripts for KLHL25 Gene

mRNA/cDNA for KLHL25 Gene

Unigene Clusters for KLHL25 Gene

Kelch-like family member 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL25 Gene

No ASD Table

Relevant External Links for KLHL25 Gene

GeneLoc Exon Structure for
KLHL25
ECgene alternative splicing isoforms for
KLHL25

Expression for KLHL25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL25 Gene

Protein differential expression in normal tissues from HIPED for KLHL25 Gene

This gene is overexpressed in Esophagus (37.2) and Stomach (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHL25 Gene



Protein tissue co-expression partners for KLHL25 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL25 Gene:

KLHL25

SOURCE GeneReport for Unigene cluster for KLHL25 Gene:

Hs.498371

Evidence on tissue expression from TISSUES for KLHL25 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with KLHL25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL25 Gene

Orthologs for KLHL25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL25 34 35
  • 99.38 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL25 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL25 34 35
  • 91.4 (n)
cow
(Bos Taurus)
Mammalia KLHL25 34 35
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Klhl25 34 16 35
  • 87.72 (n)
rat
(Rattus norvegicus)
Mammalia Klhl25 34
  • 87.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL25 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL25 34 35
  • 80.48 (n)
lizard
(Anolis carolinensis)
Reptilia KLHL25 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl25 34
  • 72.72 (n)
zebrafish
(Danio rerio)
Actinopterygii enc3 35
  • 72 (a)
ManyToMany
si:ch211-256e16.3 35
  • 28 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6382 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for KLHL25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL25 Gene

ENSEMBL:
Gene Tree for KLHL25 (if available)
TreeFam:
Gene Tree for KLHL25 (if available)

Paralogs for KLHL25 Gene

(19) SIMAP similar genes for KLHL25 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KLHL25 Gene

genes like me logo Genes that share paralogs with KLHL25: view

Variants for KLHL25 Gene

Sequence variations from dbSNP and Humsavar for KLHL25 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000016188 -- 85,765,077(+) CCTCT(C/G)GTCTG intron-variant
rs1000076838 -- 85,770,869(+) CTCAA(A/T)CTAGG intron-variant, upstream-variant-2KB
rs1000206012 -- 85,759,541(+) TTCGG(A/G)CAGCT upstream-variant-2KB, utr-variant-3-prime
rs1000274426 -- 85,779,973(+) CCGTC(C/G)TAAAA intron-variant
rs1000280066 -- 85,766,579(+) CAGAT(A/G)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL25 Gene

Variant ID Type Subtype PubMed ID
dgv2649n100 CNV gain 25217958
dgv2650n100 CNV gain 25217958
dgv2651n100 CNV loss 25217958
esv2760369 CNV loss 21179565
esv3637123 CNV loss 21293372
nsv471258 CNV loss 18288195
nsv516322 CNV loss 19592680
nsv570353 CNV loss 21841781
nsv570354 CNV loss 21841781
nsv977753 CNV duplication 23825009

Variation tolerance for KLHL25 Gene

Residual Variation Intolerance Score: 6.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL25 Gene

Human Gene Mutation Database (HGMD)
KLHL25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL25 Gene

Disorders for KLHL25 Gene

Relevant External Links for KLHL25

Genetic Association Database (GAD)
KLHL25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL25

No disorders were found for KLHL25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL25 Gene

Publications for KLHL25 Gene

  1. Translational homeostasis via the mRNA cap-binding protein, eIF4E. (PMID: 22578813) Yanagiya A. … Sonenberg N. (Mol. Cell 2012) 3 4 64
  2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for KLHL25 Gene

Sources for KLHL25 Gene

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