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Aliases for KLHL25 Gene

Aliases for KLHL25 Gene

  • Kelch Like Family Member 25 2 3 5
  • Ectoderm-Neural Cortex Protein 2 3 4
  • Ectodermal-Neural Cortex 2 2 3
  • ENC-2 3 4
  • ENC2 3 4
  • BTB/POZ KELCH Domain Protein 3
  • Kelch-Like 25 (Drosophila) 2
  • Kelch-Like Protein 25 3
  • Kelch-Like 25 3

External Ids for KLHL25 Gene

Previous GeneCards Identifiers for KLHL25 Gene

  • GC15M084105
  • GC15M086302
  • GC15M062365
  • GC15M085771
  • GC15M085783
  • GC15M085797
  • GC15M085816

Summaries for KLHL25 Gene

GeneCards Summary for KLHL25 Gene

KLHL25 (Kelch Like Family Member 25) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ENC1.

UniProtKB/Swiss-Prot for KLHL25 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Gene Wiki entry for KLHL25 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL25 Gene

Genomics for KLHL25 Gene

Regulatory Elements for KLHL25 Gene

Enhancers for KLHL25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F085836 1.5 Ensembl ENCODE 23.7 -43.7 -43679 4.6 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 SLC30A9 KLHL25 MIR1276 LOC105370952 ENSG00000259608
GH15F085832 0.4 Ensembl 22 -37.5 -37471 0.7 KLHL25 MIR1276 LOC105370952 MIR548AP
GH15F085824 0.4 ENCODE 17.8 -30.2 -30245 0.8 ZNF217 SREBF1 ZHX2 MNT ZBTB40 KLHL25 ENSG00000259407 MIR548AP RNU6-231P
GH15F085831 0.7 Ensembl ENCODE 15.7 -36.8 -36771 0.4 CTCF CBX1 ZNF654 SMARCA4 ARID4B SMC3 RAD21 KLHL25 MIR1276 LOC105370952 MIR548AP
GH15F085757 0.6 Ensembl 11.9 +37.9 37930 0.2 ZNF263 CEBPB KLHL25 ENSG00000259407 ENSG00000259762 LOC101929679
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KLHL25 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128216 330 1801 PKNOX1 ARID4B SIN3A YY1 GLIS2 ZNF143 FOS ZNF263 SP3 NFYC

Genomic Location for KLHL25 Gene

Chromosome:
15
Start:
85,759,323 bp from pter
End:
85,795,030 bp from pter
Size:
35,708 bases
Orientation:
Minus strand

Genomic View for KLHL25 Gene

Genes around KLHL25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL25 Gene

Proteins for KLHL25 Gene

  • Protein details for KLHL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0H3-KLH25_HUMAN
    Recommended name:
    Kelch-like protein 25
    Protein Accession:
    Q9H0H3
    Secondary Accessions:
    • B2RDH2
    • B3KRT7

    Protein attributes for KLHL25 Gene

    Size:
    589 amino acids
    Molecular mass:
    65923 Da
    Quaternary structure:
    • Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. Interacts with EIF4EBP1 (when hypophosphorylated).

neXtProt entry for KLHL25 Gene

Post-translational modifications for KLHL25 Gene

  • Ubiquitination at Lys 263
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL25 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KLHL25
  • Santa Cruz Biotechnology (SCBT) Antibodies for KLHL25

No data available for DME Specific Peptides for KLHL25 Gene

Domains & Families for KLHL25 Gene

Gene Families for KLHL25 Gene

Suggested Antigen Peptide Sequences for KLHL25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0H3

UniProtKB/Swiss-Prot:

KLH25_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL25: view

Function for KLHL25 Gene

Molecular function for KLHL25 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Phenotypes for KLHL25 Gene

genes like me logo Genes that share phenotypes with KLHL25: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL25 Gene

Localization for KLHL25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL25 Gene COMPARTMENTS Subcellular localization image for KLHL25 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for KLHL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 22578813
genes like me logo Genes that share ontologies with KLHL25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL25 Gene

Pathways & Interactions for KLHL25 Gene

genes like me logo Genes that share pathways with KLHL25: view

UniProtKB/Swiss-Prot Q9H0H3-KLH25_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KLHL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0006446 regulation of translational initiation IDA 22578813
GO:0016567 protein ubiquitination IDA 22578813
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 22578813
genes like me logo Genes that share ontologies with KLHL25: view

No data available for SIGNOR curated interactions for KLHL25 Gene

Transcripts for KLHL25 Gene

mRNA/cDNA for KLHL25 Gene

Unigene Clusters for KLHL25 Gene

Kelch-like family member 25:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL25 Gene

No ASD Table

Relevant External Links for KLHL25 Gene

GeneLoc Exon Structure for
KLHL25
ECgene alternative splicing isoforms for
KLHL25

Expression for KLHL25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLHL25 Gene

Protein differential expression in normal tissues from HIPED for KLHL25 Gene

This gene is overexpressed in Esophagus (37.2) and Stomach (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHL25 Gene



Protein tissue co-expression partners for KLHL25 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL25 Gene:

KLHL25

SOURCE GeneReport for Unigene cluster for KLHL25 Gene:

Hs.498371
genes like me logo Genes that share expression patterns with KLHL25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL25 Gene

Orthologs for KLHL25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL25 34 35
  • 99.38 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL25 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL25 34 35
  • 91.4 (n)
cow
(Bos Taurus)
Mammalia KLHL25 34 35
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Klhl25 34 16 35
  • 87.72 (n)
rat
(Rattus norvegicus)
Mammalia Klhl25 34
  • 87.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL25 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL25 34 35
  • 80.48 (n)
lizard
(Anolis carolinensis)
Reptilia KLHL25 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl25 34
  • 72.72 (n)
zebrafish
(Danio rerio)
Actinopterygii enc3 35
  • 72 (a)
ManyToMany
si:ch211-256e16.3 35
  • 28 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6382 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for KLHL25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL25 Gene

ENSEMBL:
Gene Tree for KLHL25 (if available)
TreeFam:
Gene Tree for KLHL25 (if available)

Paralogs for KLHL25 Gene

Paralogs for KLHL25 Gene

(19) SIMAP similar genes for KLHL25 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KLHL25 Gene

genes like me logo Genes that share paralogs with KLHL25: view

Variants for KLHL25 Gene

Sequence variations from dbSNP and Humsavar for KLHL25 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10535328 -- 85,775,865(+) CGTTT(-/AA)AAAAA intron-variant
rs11073537 -- 85,769,450(-) CACTG(C/T)TGGAG reference, synonymous-codon
rs111264798 -- 85,789,401(+) TTTTT(C/G)ACAGA intron-variant
rs111577038 -- 85,783,448(+) GCACT(C/T)TGGGA intron-variant
rs111578069 -- 85,794,782(+) ATCCC(C/T)GCCGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL25 Gene

Variant ID Type Subtype PubMed ID
dgv2649n100 CNV gain 25217958
dgv2650n100 CNV gain 25217958
dgv2651n100 CNV loss 25217958
esv2760369 CNV loss 21179565
esv3637123 CNV loss 21293372
nsv471258 CNV loss 18288195
nsv516322 CNV loss 19592680
nsv570353 CNV loss 21841781
nsv570354 CNV loss 21841781
nsv977753 CNV duplication 23825009

Variation tolerance for KLHL25 Gene

Residual Variation Intolerance Score: 6.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL25 Gene

Disorders for KLHL25 Gene

Relevant External Links for KLHL25

Genetic Association Database (GAD)
KLHL25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL25

No disorders were found for KLHL25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL25 Gene

Publications for KLHL25 Gene

  1. Translational homeostasis via the mRNA cap-binding protein, eIF4E. (PMID: 22578813) Yanagiya A. … Sonenberg N. (Mol. Cell 2012) 3 4 64
  2. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta K.L. … Murabito J.M. (BMC Med. Genet. 2007) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64

Products for KLHL25 Gene

Sources for KLHL25 Gene

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