Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLHL25 Gene

Aliases for KLHL25 Gene

  • Kelch Like Family Member 25 2 3 5
  • Ectoderm-Neural Cortex Protein 2 3 4
  • Ectodermal-Neural Cortex 2 2 3
  • ENC-2 3 4
  • ENC2 3 4
  • BTB/POZ KELCH Domain Protein 3
  • Kelch-Like Family Member 25 3
  • Kelch-Like 25 (Drosophila) 2
  • Kelch-Like 25 3

External Ids for KLHL25 Gene

Previous GeneCards Identifiers for KLHL25 Gene

  • GC15M084105
  • GC15M086302
  • GC15M062365
  • GC15M085771
  • GC15M085783

Summaries for KLHL25 Gene

GeneCards Summary for KLHL25 Gene

KLHL25 (Kelch Like Family Member 25) is a Protein Coding gene. An important paralog of this gene is KBTBD4.

UniProtKB/Swiss-Prot for KLHL25 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Gene Wiki entry for KLHL25 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL25 Gene

Genomics for KLHL25 Gene

Regulatory Elements for KLHL25 Gene

Enhancers for KLHL25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL25 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL25 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL25 Gene

Chromosome:
15
Start:
85,759,323 bp from pter
End:
85,795,030 bp from pter
Size:
35,708 bases
Orientation:
Minus strand

Genomic View for KLHL25 Gene

Genes around KLHL25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL25 Gene

Proteins for KLHL25 Gene

  • Protein details for KLHL25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0H3-KLH25_HUMAN
    Recommended name:
    Kelch-like protein 25
    Protein Accession:
    Q9H0H3
    Secondary Accessions:
    • B2RDH2
    • B3KRT7

    Protein attributes for KLHL25 Gene

    Size:
    589 amino acids
    Molecular mass:
    65923 Da
    Quaternary structure:
    • Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. Interacts with EIF4EBP1 (when hypophosphorylated).

neXtProt entry for KLHL25 Gene

Proteomics data for KLHL25 Gene at MOPED

Post-translational modifications for KLHL25 Gene

  • Ubiquitination at Lys 263
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL25 Gene

Domains & Families for KLHL25 Gene

Gene Families for KLHL25 Gene

Protein Domains for KLHL25 Gene

Suggested Antigen Peptide Sequences for KLHL25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0H3

UniProtKB/Swiss-Prot:

KLH25_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL25: view

Function for KLHL25 Gene

Molecular function for KLHL25 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Phenotypes for KLHL25 Gene

genes like me logo Genes that share phenotypes with KLHL25: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL25 Gene

Localization for KLHL25 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL25 Gene COMPARTMENTS Subcellular localization image for KLHL25 gene
Compartment Confidence
cytosol 4
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL25 Gene

Pathways & Interactions for KLHL25 Gene

SuperPathways for KLHL25 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H0H3-KLH25_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for KLHL25 Gene

Gene Ontology (GO) - Biological Process for KLHL25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IDA 22578813
genes like me logo Genes that share ontologies with KLHL25: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL25 Gene

Drugs & Compounds for KLHL25 Gene

No Compound Related Data Available

Transcripts for KLHL25 Gene

mRNA/cDNA for KLHL25 Gene

Unigene Clusters for KLHL25 Gene

Kelch-like family member 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL25 Gene

No ASD Table

Relevant External Links for KLHL25 Gene

GeneLoc Exon Structure for
KLHL25
ECgene alternative splicing isoforms for
KLHL25

Expression for KLHL25 Gene

mRNA expression in normal human tissues for KLHL25 Gene

Protein differential expression in normal tissues from HIPED for KLHL25 Gene

This gene is overexpressed in Esophagus (37.2) and Stomach (31.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL25 Gene



SOURCE GeneReport for Unigene cluster for KLHL25 Gene Hs.498371

genes like me logo Genes that share expression patterns with KLHL25: view

Protein tissue co-expression partners for KLHL25 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL25 Gene

Orthologs for KLHL25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL25 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHL25 35
  • 88.79 (n)
  • 95.59 (a)
KLHL25 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL25 35
  • 91.4 (n)
  • 97.79 (a)
KLHL25 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl25 35
  • 87.72 (n)
  • 94.91 (a)
Klhl25 16
Klhl25 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHL25 35
  • 99.38 (n)
  • 99.83 (a)
KLHL25 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl25 35
  • 87.66 (n)
  • 94.74 (a)
oppossum
(Monodelphis domestica)
Mammalia KLHL25 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL25 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL25 35
  • 80.48 (n)
  • 90.15 (a)
KLHL25 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL25 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl25 35
  • 72.72 (n)
  • 85.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6382 35
zebrafish
(Danio rerio)
Actinopterygii enc3 36
  • 72 (a)
ManyToMany
si:ch211-256e16.3 36
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for KLHL25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL25 Gene

ENSEMBL:
Gene Tree for KLHL25 (if available)
TreeFam:
Gene Tree for KLHL25 (if available)

Paralogs for KLHL25 Gene

(19) SIMAP similar genes for KLHL25 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KLHL25 Gene

genes like me logo Genes that share paralogs with KLHL25: view

Variants for KLHL25 Gene

Sequence variations from dbSNP and Humsavar for KLHL25 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs35582838 - 85,769,063(+) GGAGA(C/T)GGCCT reference, missense
rs36031133 - 85,769,042(+) TGCCA(A/T)GAGGA reference, missense
rs5814216 -- 85,789,388(+) ATCCC(-/T)TTTTT intron-variant
rs888370 -- 85,781,106(-) ccacc(C/T)acctt intron-variant
rs12232254 -- 85,775,892(+) AAAGC(A/G)GCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL25 Gene

Variant ID Type Subtype PubMed ID
nsv516322 CNV Loss 19592680
nsv904464 CNV Loss 21882294
nsv471258 CNV Loss 18288195

Variation tolerance for KLHL25 Gene

Residual Variation Intolerance Score: 6.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLHL25 Gene

Disorders for KLHL25 Gene

Relevant External Links for KLHL25

Genetic Association Database (GAD)
KLHL25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL25

No disorders were found for KLHL25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL25 Gene

Publications for KLHL25 Gene

  1. Translational homeostasis via the mRNA cap-binding protein, eIF4E. (PMID: 22578813) Yanagiya A. … Sonenberg N. (Mol. Cell 2012) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. (PMID: 23594818) Ikeda M. … Iwata N. (Neuropsychopharmacology 2013) 3
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  5. A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. (PMID: 24025145) Chung S. … Nakamura Y. (Breast Cancer Res. 2013) 3

Products for KLHL25 Gene

Sources for KLHL25 Gene

Content