Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLHL24 Gene

Aliases for KLHL24 Gene

  • Kelch-Like Family Member 24 2 3
  • KRIP6 3 4 6
  • Kainate Receptor-Interacting Protein For GluR6 3 4
  • DRE1 3 4
  • Kainate Receptor Interacting Protein For GluR6 3
  • Kelch-Like 24 (Drosophila) 2
  • Kelch-Like Protein 24 3
  • Kelch-Like 24 3
  • Protein DRE1 4

External Ids for KLHL24 Gene

Previous GeneCards Identifiers for KLHL24 Gene

  • GC03P184837
  • GC03P183353
  • GC03P180759

Summaries for KLHL24 Gene

GeneCards Summary for KLHL24 Gene

KLHL24 (Kelch-Like Family Member 24) is a Protein Coding gene. Diseases associated with KLHL24 include urethral stricture and neurogenic bladder. An important paralog of this gene is KBTBD6.

UniProtKB/Swiss-Prot for KLHL24 Gene

  • Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL24 Gene

Genomics for KLHL24 Gene

Regulatory Elements for KLHL24 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL24 Gene

Start:
183,635,568 bp from pter
End:
183,684,519 bp from pter
Size:
48,952 bases
Orientation:
Plus strand

Genomic View for KLHL24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL24 Gene

Proteins for KLHL24 Gene

  • Protein details for KLHL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6TFL4-KLH24_HUMAN
    Recommended name:
    Kelch-like protein 24
    Protein Accession:
    Q6TFL4
    Secondary Accessions:
    • A5PLN8
    • Q9H620
    • Q9NXT9

    Protein attributes for KLHL24 Gene

    Size:
    600 amino acids
    Molecular mass:
    68361 Da
    Quaternary structure:
    • Forms homodimers. Interacts with GRIK2 (By similarity).
    SequenceCaution:
    • Sequence=BAA90921.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15447.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL24 Gene

Proteomics data for KLHL24 Gene at MOPED

Post-translational modifications for KLHL24 Gene

  • Ubiquitination at Lys181 and Lys441
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KLHL24 Gene

Domains for KLHL24 Gene

Gene Families for KLHL24 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6TFL4

UniProtKB/Swiss-Prot:

KLH24_HUMAN :
  • Q6TFL4
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL24: view

Function for KLHL24 Gene

Molecular function for KLHL24 Gene

UniProtKB/Swiss-Prot Function: Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.

Gene Ontology (GO) - Molecular Function for KLHL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL24: view

Phenotypes for KLHL24 Gene

GenomeRNAi human phenotypes for KLHL24:
genes like me logo Genes that share phenotypes with KLHL24: view

Animal Model Products

CRISPR Products

miRNA for KLHL24 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL24

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL24 Gene

Localization for KLHL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL24 Gene

Perikaryon. Cell projection, axon. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL24 Gene COMPARTMENTS Subcellular localization image for KLHL24 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KLHL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0030424 axon IEA --
GO:0042995 cell projection --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with KLHL24: view

Pathways for KLHL24 Gene

SuperPathways for KLHL24 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KLHL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2000312 regulation of kainate selective glutamate receptor activity IEA --
genes like me logo Genes that share ontologies with KLHL24: view

No data available for Pathways by source for KLHL24 Gene

Transcripts for KLHL24 Gene

Unigene Clusters for KLHL24 Gene

Kelch-like family member 24:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL24

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KLHL24

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL24 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: -
SP11: - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - -
SP14: -

Relevant External Links for KLHL24 Gene

GeneLoc Exon Structure for
KLHL24
ECgene alternative splicing isoforms for
KLHL24

Expression for KLHL24 Gene

mRNA expression in normal human tissues for KLHL24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL24 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

SOURCE GeneReport for Unigene cluster for KLHL24 Gene Hs.407709

genes like me logo Genes that share expressions with KLHL24: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for KLHL24 Gene

Orthologs for KLHL24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL24 35
  • 99.72 (n)
  • 99.83 (a)
KLHL24 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHL24 35
  • 95.28 (n)
  • 99.67 (a)
KLHL24 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL24 35
  • 95.44 (n)
  • 99.83 (a)
KLHL24 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl24 35
  • 91.94 (n)
  • 99.33 (a)
Klhl24 16
Klhl24 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL24 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL24 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl24 35
  • 91.22 (n)
  • 99.33 (a)
chicken
(Gallus gallus)
Aves KLHL24 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL24 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl24 35
  • 78.78 (n)
  • 90.83 (a)
zebrafish
(Danio rerio)
Actinopterygii klhl24a 35
  • 70.07 (n)
  • 78.39 (a)
klhl24a 36
  • 78 (a)
OneToMany
klhl24b 36
  • 85 (a)
OneToMany
zgc63606 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for KLHL24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL24 Gene

ENSEMBL:
Gene Tree for KLHL24 (if available)
TreeFam:
Gene Tree for KLHL24 (if available)

Paralogs for KLHL24 Gene

genes like me logo Genes that share paralogs with KLHL24: view

Variants for KLHL24 Gene

Sequence variations from dbSNP and Humsavar for KLHL24 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9813 -- 183,684,341(-) TTCTT(C/T)CCACT utr-variant-3-prime, nc-transcript-variant
rs830179 -- 183,662,247(-) AATCA(C/T)GTACC intron-variant
rs1055706 -- 183,680,590(+) AATCA(A/T)CATTT utr-variant-3-prime, nc-transcript-variant
rs1456330 -- 183,683,179(-) CGAGG(C/T)GGGCG utr-variant-3-prime, nc-transcript-variant
rs1979251 -- 183,667,215(-) GTCTC(A/G)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL24 Gene

Variant ID Type Subtype PubMed ID
esv2660932 CNV Deletion 23128226
esv1329997 CNV Insertion 17803354
esv27076 CNV Loss 19812545

Relevant External Links for KLHL24 Gene

HapMap Linkage Disequilibrium report
KLHL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL24 Gene

Disorders for KLHL24 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for KLHL24 Gene including...

Search for KLHL24 Gene in MalaCards »

(2) University of Copenhagen DISEASES for KLHL24 Gene

genes like me logo Genes that share disorders with KLHL24: view

No data available for UniProtKB/Swiss-Prot for KLHL24 Gene

Publications for KLHL24 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. KRIP6: a novel BTB/kelch protein regulating function of kainate receptors. (PMID: 17254796) Laezza F. … Craig A.M. (Mol. Cell. Neurosci. 2007) 3
  3. The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptors. (PMID: 18692513) Laezza F. … Huettner J.E. (Neuropharmacology 2008) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for KLHL24 Gene

Sources for KLHL24 Gene

Back to Top

Content