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Aliases for KLHL24 Gene

Aliases for KLHL24 Gene

  • Kelch-Like Family Member 24 2 3
  • Kainate Receptor-Interacting Protein For GluR6 3 4
  • KRIP6 3 4
  • DRE1 3 4
  • Kainate Receptor Interacting Protein For GluR6 3
  • Kelch-Like 24 (Drosophila) 2
  • Kelch-Like 24 3
  • Protein DRE1 4

External Ids for KLHL24 Gene

Previous GeneCards Identifiers for KLHL24 Gene

  • GC03P184837
  • GC03P183353
  • GC03P180759

Summaries for KLHL24 Gene

GeneCards Summary for KLHL24 Gene

KLHL24 (Kelch-Like Family Member 24) is a Protein Coding gene. Diseases associated with KLHL24 include urethral stricture and urethral obstruction. An important paralog of this gene is KBTBD6.

UniProtKB/Swiss-Prot for KLHL24 Gene

  • Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL24 Gene

Genomics for KLHL24 Gene

Regulatory Elements for KLHL24 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL24 Gene

Chromosome:
3
Start:
183,635,011 bp from pter
End:
183,684,519 bp from pter
Size:
49,509 bases
Orientation:
Plus strand

Genomic View for KLHL24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL24 Gene

Proteins for KLHL24 Gene

  • Protein details for KLHL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6TFL4-KLH24_HUMAN
    Recommended name:
    Kelch-like protein 24
    Protein Accession:
    Q6TFL4
    Secondary Accessions:
    • A5PLN8
    • Q9H620
    • Q9NXT9

    Protein attributes for KLHL24 Gene

    Size:
    600 amino acids
    Molecular mass:
    68361 Da
    Quaternary structure:
    • Forms homodimers. Interacts with GRIK2 (By similarity).
    SequenceCaution:
    • Sequence=BAA90921.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15447.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL24 Gene

Proteomics data for KLHL24 Gene at MOPED

Post-translational modifications for KLHL24 Gene

  • Ubiquitination at Lys 181 and Lys 441
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KLHL24 Gene

Domains & Families for KLHL24 Gene

Gene Families for KLHL24 Gene

Suggested Antigen Peptide Sequences for KLHL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6TFL4

UniProtKB/Swiss-Prot:

KLH24_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL24: view

Function for KLHL24 Gene

Molecular function for KLHL24 Gene

UniProtKB/Swiss-Prot Function:
Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.

Gene Ontology (GO) - Molecular Function for KLHL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL24: view

Phenotypes for KLHL24 Gene

GenomeRNAi human phenotypes for KLHL24:
genes like me logo Genes that share phenotypes with KLHL24: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL24

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL24 Gene

Localization for KLHL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL24 Gene

Perikaryon. Cell projection, axon. Cytoplasm.

Gene Ontology (GO) - Cellular Components for KLHL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0030424 axon IEA --
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
GO:0043204 perikaryon IEA --
genes like me logo Genes that share ontologies with KLHL24: view

No data available for Subcellular locations from COMPARTMENTS for KLHL24 Gene

Pathways & Interactions for KLHL24 Gene

SuperPathways for KLHL24 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for KLHL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
GO:2000312 regulation of kainate selective glutamate receptor activity --
genes like me logo Genes that share ontologies with KLHL24: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL24 Gene

Drugs & Compounds for KLHL24 Gene

No Compound Related Data Available

Transcripts for KLHL24 Gene

Unigene Clusters for KLHL24 Gene

Kelch-like family member 24:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL24

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL24 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - - - - - -
SP10: -
SP11: - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - -
SP14: -

Relevant External Links for KLHL24 Gene

GeneLoc Exon Structure for
KLHL24
ECgene alternative splicing isoforms for
KLHL24

Expression for KLHL24 Gene

mRNA expression in normal human tissues for KLHL24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLHL24 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

SOURCE GeneReport for Unigene cluster for KLHL24 Gene Hs.407709

genes like me logo Genes that share expression patterns with KLHL24: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KLHL24 Gene

Orthologs for KLHL24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHL24 35
  • 95.28 (n)
  • 99.67 (a)
KLHL24 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL24 35
  • 95.44 (n)
  • 99.83 (a)
KLHL24 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl24 35
  • 91.94 (n)
  • 99.33 (a)
Klhl24 16
Klhl24 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHL24 35
  • 99.72 (n)
  • 99.83 (a)
KLHL24 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl24 35
  • 91.22 (n)
  • 99.33 (a)
oppossum
(Monodelphis domestica)
Mammalia KLHL24 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL24 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL24 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL24 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl24 35
  • 78.78 (n)
  • 90.83 (a)
zebrafish
(Danio rerio)
Actinopterygii klhl24a 35
  • 70.07 (n)
  • 78.39 (a)
zgc63606 35
klhl24a 36
  • 78 (a)
OneToMany
klhl24b 36
  • 85 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for KLHL24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL24 Gene

ENSEMBL:
Gene Tree for KLHL24 (if available)
TreeFam:
Gene Tree for KLHL24 (if available)

Paralogs for KLHL24 Gene

genes like me logo Genes that share paralogs with KLHL24: view

Variants for KLHL24 Gene

Sequence variations from dbSNP and Humsavar for KLHL24 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9813 -- 183,684,341(-) TTCTT(C/T)CCACT utr-variant-3-prime, nc-transcript-variant
rs830179 -- 183,662,247(-) AATCA(C/T)GTACC intron-variant
rs1055706 -- 183,680,590(+) AATCA(A/T)CATTT utr-variant-3-prime, nc-transcript-variant
rs1456330 -- 183,683,179(-) CGAGG(C/T)GGGCG utr-variant-3-prime, nc-transcript-variant
rs1979251 -- 183,667,215(-) GTCTC(A/G)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL24 Gene

Variant ID Type Subtype PubMed ID
esv2660932 CNV Deletion 23128226
esv1329997 CNV Insertion 17803354
esv27076 CNV Loss 19812545

Variation tolerance for KLHL24 Gene

Residual Variation Intolerance Score: 13.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.38; 71.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL24 Gene

HapMap Linkage Disequilibrium report
KLHL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL24 Gene

Disorders for KLHL24 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KLHL24 Gene - From: DISEASES

Disorder Aliases PubMed IDs
urethral stricture
urethral obstruction
  • obstruction of urethra
- elite association

Relevant External Links for KLHL24

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL24
genes like me logo Genes that share disorders with KLHL24: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLHL24 Gene

Publications for KLHL24 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 67
  3. A microRNA encoded by HSV-1 inhibits a cellular transcriptional repressor of viral immediate early and early genes. (PMID: 23512275) Wu W. … Li Q. (Sci China Life Sci 2013) 67
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 67
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 67

Products for KLHL24 Gene

Sources for KLHL24 Gene

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