KLHL24 Gene
protein-coding GIFtS: 48
GCID: GC03P183353
|
|
kelch-like family member 24(Previous name: kelch-like 24 (Drosophila) )
| |
Aliases
for KLHL24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 241 2 | | Kelch-Like 24 (Drosophila)1 | | DRE11 2 3 | | Kainate Receptor Interacting Protein For GluR62 | | Kainate Receptor-Interacting Protein For GluR62 3 | | Kelch-Like 242 | | KRIP62 3 | | Kelch-Like Protein 242 | | FLJ200591 | | Protein DRE13 |
Export aliases for KLHL24 gene to outside databasesPrevious GC identifers: GC03P184837 GC03P180759 |
Summaries
for KLHL24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KLH24_HUMAN, Q6TFL4Function: Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulatingchannel properties (By similarity)
|
Genomic Views
for KLHL24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL24 gene promoter:
ER-alpha NF-1 GATA-3 AML1a GATA-1 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27.1KLHL24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P183353: view genomic region
(about GC identifiers)
Start:
|
183,353,356 bp from pter |
End:
|
183,402,307 bp from pter |
Size:
|
48,952 bases |
Orientation:
|
plus strand |
|
Proteins
for KLHL24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLH24_HUMAN, Q6TFL4 (See
protein sequence)Recommended Name: Kelch-like protein 24 Size: 600 amino acids; 68361 Da
Subunit: Forms homodimers. Interacts with GRIK2 (By similarity)
Subcellular location: Perikaryon. Cell projection, axon (By similarity). Cytoplasm (By similarity)
Sequence caution: Sequence=BAA90921.1; Type=Erroneous initiation; Sequence=BAB15447.1; Type=Miscellaneous discrepancy;Note=Aberrant splicing;
Secondary accessions: A5PLN8 Q9H620 Q9NXT9Alternative splicing: 2 isoforms: Q6TFL4-1 Q6TFL4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KLHL24: NX_Q6TFL4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6TFL4
KLHL24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060114.2
ENSEMBL proteins: ENSP00000242810 ENSP00000417347 ENSP00000408516 ENSP00000416836 ENSP00000419120 ENSP00000420207 ENSP00000408567 ENSP00000417275 ENSP00000395012 ENSP00000418922 ENSP00000419010
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
KLHL24 for ontologies About GeneDecksing
KLHL24 Antibody Products:
Assay Products for KLHL24: |
Protein
Domains /
Families
for KLHL24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHL24 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q6TFL4ProtoNet protein and cluster: Q6TFL4 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KLH24_HUMAN, Q6TFL4Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats |
Function
for KLHL24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KLH24_HUMAN, Q6TFL4Function: Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulatingchannel properties (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL24 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: KLHL24 (NM_017644) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL24 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL24 |
1 GenomeRNAi human phenotype for KLHL24:
|
Pathways & Interactions
for KLHL24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL24
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for KLHL24 (Q6TFL43 ENSP000002428104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KLHL24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL24
Search CenterWatch for drugs/clinical trials and news about KLHL24 / KLH24
|
Transcripts
for KLHL24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL24 gene: NM_017644.3 Unigene Cluster for KLHL24: Kelch-like 24 (Drosophila) Hs.407709 [show with all ESTs]Unigene Representative Sequence: NM_01764415 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000242810 ENST00000493074 ENST00000437402 ENST00000454495 ENST00000461813
ENST00000473045 ENST00000468101 ENST00000427201 ENST00000482138 ENST00000454652(uc003flv.3 uc003flw.3)
ENST00000481126 ENST00000475827 ENST00000468001 ENST00000476808(uc003flx.3)
ENST00000492409
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL24 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL24
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHL24 (NM_017644) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL24 |
Additional cDNA sequence: AK024270.1 AK026326.1 AK098662.1 AY422472.1 BC142993.1 BX648466.1 BX648812.1 DQ925701.1 11 DOTS entries: DT.97823461 DT.97819697 DT.86836411 DT.211826 DT.95366851 DT.91708990 DT.99996614 DT.40296602 DT.97806228 DT.120899573 DT.86839446 24/87 AceView cDNA sequences (see all 87): AI919185 AA897658 AK098662 CF139527 AA283143 AA743489 BX485702 BU608337 AW003730 AW001771 CK902487 NM_017644 AA714790 CK902488 AA282914 AY422472 AI889572 AI494013 BX648466 T57430 N80089 AI375165 AW006750 N64655
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL24 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | · | 6i | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KLHL24
|
Expression
for KLHL24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGTTTAA
About this image
See KLHL24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL24
SOURCE GeneReport for Unigene cluster: Hs.407709
SABiosciences Expression via Pathway-Focused PCR Array including KLHL24:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL24
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL24 |
Orthologs
for KLHL24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KLHL24 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KLHL241 |
kelch-like 24 (Drosophila) |
81.84(n)
96.75(a) |
|
424763 NM_001031304.1 NP_001026475.1 |
lizard
(Anolis carolinensis) |
Reptilia |
KLHL246 |
-- |
95(a) |
1 ↔ 1 |
3(37835509-37844204) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc636062 |
hypothetical protein MGC63606 |
79.16(n) |
|
393412 BC054921.1 |
ENSEMBL Gene Tree for KLHL24 (if available)
TreeFam Gene Tree for KLHL24 (if available) |
Paralogs
for KLHL24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL24 gene
- KLHL382 KLHL212 KLHL292 KLHL62 KLHL232 KBTBD32 KLHL112 ENC12
- KLHL252 KLHL302 KLHL352 CCIN2
18/34 SIMAP similar genes for KLHL24 using alignment to 9 protein entries: KLH24_HUMAN (see all proteins)
(see all similar genes):KLHL14 KBTBD2 FLJ00029 KBTBD3 ZBTB7C ZNF131
KLHL6 SPOP KLHL3 KLHL2 KBTBD8 KLHL20
KLHL35 BACH2 KLHL17 KLHL29 KLHL32 KLHL36
KLHL24 for paralogs About GeneDecksing
|
Genomic Variants
for KLHL24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHL24 (183353356 - 183402307 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KLHL24
1 CNV: 23672
1 Indel: 68512 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL24 |
|
Disorders
/ Diseases
for KLHL24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLHL24 for disorders About GeneDecksing
OMIM gene information: 611295
OMIM disorders: --
4  diseases for KLHL24: About MalaCardsurethral stricture neurogenic bladder urethritis neuronitis
2 diseases from the University of Copenhagen DISEASES database for KLHL24:Urethral stricture Neurogenic bladder Export disorders for KLHL24 gene to outside databases
|
Publications
for KLHL24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL24 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with KLHL24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptors. (PubMed id 18692513)1 Laezza F....Huettner J.E. (2008)
- KRIP6: a novel BTB/kelch protein regulating function of kainate receptors. (PubMed id 17254796)1 Laezza F....Craig A.M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KLHL24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLHL24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHL24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLHL24 gene:
Search GeneIP for patents involving KLHL24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL24 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL24 |
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