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Aliases for KLHL23 Gene

Aliases for KLHL23 Gene

  • Kelch Like Family Member 23 2 3 5
  • Kelch-Like 23 (Drosophila) 2
  • Kelch-Like Protein 23 3
  • Kelch-Like 23 3
  • DITHP 3

External Ids for KLHL23 Gene

Previous GeneCards Identifiers for KLHL23 Gene

  • GC02P170417
  • GC02P170260
  • GC02P170551
  • GC02P162442

Summaries for KLHL23 Gene

GeneCards Summary for KLHL23 Gene

KLHL23 (Kelch Like Family Member 23) is a Protein Coding gene. Among its related pathways are Vitamin B6 metabolism. An important paralog of this gene is KLHL29.

Additional gene information for KLHL23 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL23 Gene

Genomics for KLHL23 Gene

Regulatory Elements for KLHL23 Gene

Enhancers for KLHL23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H169761 0.9 ENCODE 9.7 +67.4 67426 1 ELF3 TBP FOXA2 ATF1 ARID4B THRB RAD21 RARA YY1 SLC30A9 SSB PPIG LOC100421689 CCDC173 KLHL23 PHOSPHO2 LOC171417 GC02P169749
GH02H169507 1.5 Ensembl ENCODE dbSUPER 5.3 -183.5 -183507 7 PKNOX1 FOXA2 FEZF1 FOS JUNB TSHZ1 MEF2D MAFF SMARCA4 KDM1A BBS5 PPIG CCDC173 PHOSPHO2 FASTKD1 KLHL23 KLHL41 GC02P169518
GH02H169572 1.4 ENCODE dbSUPER 5.3 -120.9 -120889 1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FASTKD1 PHOSPHO2 KLHL23 GC02M169527
GH02H170084 1.2 ENCODE dbSUPER 6 +391.2 391220 2 HDAC1 PKNOX1 ATF1 NFRKB TCF12 ZNF766 ATF7 RUNX3 CEBPB ZEB2 MYO3B METTL5 UBR3 KLHL23 SSB LOC100421689 RNU6-1006P
GH02H169477 1.1 ENCODE 5.4 -215.4 -215351 2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP5 PHOSPHO2 FASTKD1 KLHL23 BBS5 GC02P169409
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL23 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000126010 112 1601 HDGF ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143 SP3 SP5

Genomic Location for KLHL23 Gene

Chromosome:
2
Start:
169,694,488 bp from pter
End:
169,776,989 bp from pter
Size:
82,502 bases
Orientation:
Plus strand

Genomic View for KLHL23 Gene

Genes around KLHL23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL23 Gene

Proteins for KLHL23 Gene

  • Protein details for KLHL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBE8-KLH23_HUMAN
    Recommended name:
    Kelch-like protein 23
    Protein Accession:
    Q8NBE8
    Secondary Accessions:
    • Q8N9B9
    • Q96FT8

    Protein attributes for KLHL23 Gene

    Size:
    558 amino acids
    Molecular mass:
    63923 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04490.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KLHL23 Gene

Post-translational modifications for KLHL23 Gene

  • Ubiquitination at isoforms=251 and posLast=265265
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL23 Gene

No data available for DME Specific Peptides for KLHL23 Gene

Domains & Families for KLHL23 Gene

Gene Families for KLHL23 Gene

Suggested Antigen Peptide Sequences for KLHL23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL23: view

No data available for UniProtKB/Swiss-Prot for KLHL23 Gene

Function for KLHL23 Gene

Phenotypes From GWAS Catalog for KLHL23 Gene

Gene Ontology (GO) - Molecular Function for KLHL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 25036637
genes like me logo Genes that share ontologies with KLHL23: view

Phenotypes for KLHL23 Gene

genes like me logo Genes that share phenotypes with KLHL23: view

Animal Model Products

CRISPR Products

miRNA for KLHL23 Gene

miRTarBase miRNAs that target KLHL23

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KLHL23
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL23 Gene

Localization for KLHL23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL23 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLHL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL23 Gene

Pathways & Interactions for KLHL23 Gene

SuperPathways for KLHL23 Gene

SuperPathway Contained pathways
1 Vitamin B6 metabolism
genes like me logo Genes that share pathways with KLHL23: view

Pathways by source for KLHL23 Gene

1 BioSystems pathway for KLHL23 Gene

Gene Ontology (GO) - Biological Process for KLHL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL23: view

No data available for SIGNOR curated interactions for KLHL23 Gene

Drugs & Compounds for KLHL23 Gene

No Compound Related Data Available

Transcripts for KLHL23 Gene

Unigene Clusters for KLHL23 Gene

Kelch-like family member 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KLHL23
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL23 Gene

No ASD Table

Relevant External Links for KLHL23 Gene

GeneLoc Exon Structure for
KLHL23
ECgene alternative splicing isoforms for
KLHL23

Expression for KLHL23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL23 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL23 Gene



Protein tissue co-expression partners for KLHL23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLHL23 Gene:

KLHL23

SOURCE GeneReport for Unigene cluster for KLHL23 Gene:

Hs.655150

Evidence on tissue expression from TISSUES for KLHL23 Gene

  • Nervous system(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with KLHL23: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL23 Gene

Orthologs for KLHL23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL23 33 34
  • 99.82 (n)
cow
(Bos Taurus)
Mammalia KLHL23 33 34
  • 94.09 (n)
dog
(Canis familiaris)
Mammalia KLHL23 33 34
  • 94.03 (n)
mouse
(Mus musculus)
Mammalia Klhl23 33 34
  • 90.2 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL23 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl23 33
  • 89.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL23 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL23 33 34
  • 71.48 (n)
lizard
(Anolis carolinensis)
Reptilia KLHL23 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl23 33
  • 68.94 (n)
zebrafish
(Danio rerio)
Actinopterygii klhl23 33 34
  • 64.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for KLHL23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL23 Gene

ENSEMBL:
Gene Tree for KLHL23 (if available)
TreeFam:
Gene Tree for KLHL23 (if available)

Paralogs for KLHL23 Gene

genes like me logo Genes that share paralogs with KLHL23: view

Variants for KLHL23 Gene

Sequence variations from dbSNP and Humsavar for KLHL23 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000065296 -- 169,734,341(+) GGCGG(C/G)ACGCG intron-variant
rs1000069295 -- 169,746,863(+) ACTAT(A/C)ATTTT intron-variant
rs1000177785 -- 169,740,281(+) CTACT(G/T)TTTTA intron-variant
rs1000280247 -- 169,737,551(+) TGATT(C/T)TGTTT intron-variant
rs1000332388 -- 169,737,294(+) AATGT(C/T)GGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL23 Gene

Variant ID Type Subtype PubMed ID
esv1586748 CNV insertion 17803354
esv1784706 CNV insertion 17803354
esv2721119 CNV deletion 23290073
nsv1007492 CNV gain 25217958
nsv1011368 CNV loss 25217958
nsv10201 CNV loss 18304495
nsv1072045 CNV deletion 25765185
nsv583606 CNV loss 21841781
nsv583607 CNV gain 21841781
nsv834454 CNV loss 17160897

Variation tolerance for KLHL23 Gene

Residual Variation Intolerance Score: 9.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL23 Gene

Disorders for KLHL23 Gene

Relevant External Links for KLHL23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL23

No disorders were found for KLHL23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL23 Gene

Publications for KLHL23 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 60

Products for KLHL23 Gene

Sources for KLHL23 Gene

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