Aliases for KLHL23 Gene
Aliases for KLHL23 Gene
External Ids for KLHL23 Gene
- HGNC: 27506
- Entrez Gene: 151230
- Ensembl: ENSG00000213160
- UniProtKB: Q8NBE8
Previous GeneCards Identifiers for KLHL23 Gene
- GC02P170417
- GC02P170260
- GC02P170551
- GC02P162442
Summaries for KLHL23 Gene
GeneCards Summary for KLHL23 Gene
KLHL23 (Kelch Like Family Member 23) is a Protein Coding gene. Among its related pathways are Vitamin B6 metabolism. An important paralog of this gene is KLHL29.
Additional gene information for KLHL23 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL23 Gene
Genomics for KLHL23 Gene
GeneHancer (GH) Regulatory Elements for KLHL23 Gene
Promoters and enhancers for KLHL23 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KLHL23 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KLHL23 gene promoter:
Regulatory Element Products
Genomic Locations for KLHL23 Gene
Genomic Locations for KLHL23 Gene
- chr2:169,694,488-169,776,989
- (GRCh38/hg38)
- Size:
- 82,502 bases
- Orientation:
- Plus strand
- chr2:170,550,998-170,633,499
- (GRCh37/hg19)
Genomic View for KLHL23 Gene
Genes around KLHL23 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q31.1 by Ensembl
- 2q31.1 by Entrez Gene
- 2q31.1 by HGNC
KLHL23 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)


RefSeq DNA sequence for KLHL23 Gene
Proteins for KLHL23 Gene
-
Protein details for KLHL23 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NBE8-KLH23_HUMAN
- Recommended name:
- Kelch-like protein 23
- Protein Accession:
- Q8NBE8
- Q8N9B9
- Q96FT8
Protein attributes for KLHL23 Gene
- Size:
- 558 amino acids
- Molecular mass:
- 63923 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC04490.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for KLHL23 Gene
Post-translational modifications for KLHL23 Gene
- Ubiquitination at posLast=251251 and isoforms=265
Other Protein References for KLHL23 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KLHL23
- Novus Biologicals Antibodies for KLHL23
- Invitrogen Antibodies for KLHL23
- GeneTex KLHL23 antibody for KLHL23
Protein Products
-
OriGene Purified Proteins for KLHL23
- Search Origene for MassSpec and Protein Over-expression Lysates for KLHL23
- Origene Custom Protein Services for KLHL23
- Search GeneTex for Proteins for KLHL23
-
Abcam proteins for KLHL23
Assay Products
No data available for DME Specific Peptides for KLHL23 Gene
Domains & Families for KLHL23 Gene
Gene Families for KLHL23 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KLHL23 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KLHL23 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for KLHL23 Gene
Function for KLHL23 Gene
Phenotypes From GWAS Catalog for KLHL23 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | contributes_to ubiquitin-protein transferase activity | IBA | -- |
GO:0005515 | protein binding | IPI | 25036637 |
Phenotypes for KLHL23 Gene
- GenomeRNAi human phenotypes for KLHL23:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for KLHL23
-
-
ViGene Biosciences lentiviral particle packaged cDNA for KLHL23 gene
-
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- Search ViGene Biosciences for KLHL23
CRISPR Products
-
OriGene CRISPR knockouts for KLHL23
- genomics-online: gRNA clones - Search results for 96 available KLHL23 gene related products
- Overview of 96 available KLHL23 gene related products
- Applied Biological Materials CRISPR for KLHL23
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLHL23
- GenScript: Design CRISPR guide RNA sequences for KLHL23
miRNA for KLHL23 Gene
- miRTarBase miRNAs that target KLHL23
-
- hsa-mir-128-3p (MIRT021998)
- hsa-mir-215-5p (MIRT024447)
- hsa-mir-192-5p (MIRT026423)
- hsa-mir-101-3p (MIRT027259)
- hsa-mir-24-3p (MIRT030436)
- hsa-mir-183-5p (MIRT047139)
- hsa-mir-10a-5p (MIRT047649)
- hsa-mir-518c-5p (MIRT299259)
- hsa-mir-4643 (MIRT407185)
- hsa-mir-1277-5p (MIRT445146)
- hsa-mir-578 (MIRT445147)
- hsa-mir-526b-5p (MIRT445148)
- hsa-mir-190a-3p (MIRT445149)
- hsa-mir-591 (MIRT445150)
- hsa-mir-5011-5p (MIRT445151)
- hsa-mir-410-3p (MIRT445152)
- hsa-mir-620 (MIRT511268)
- hsa-mir-1277-3p (MIRT511269)
- hsa-mir-4789-5p (MIRT511270)
- hsa-mir-3941 (MIRT511271)
- hsa-mir-223-5p (MIRT511272)
- hsa-mir-511-3p (MIRT511273)
- hsa-mir-4789-3p (MIRT511274)
- hsa-mir-603 (MIRT511275)
- hsa-mir-362-3p (MIRT511276)
- hsa-mir-329-3p (MIRT511277)
- hsa-mir-8485 (MIRT511278)
- hsa-mir-5580-3p (MIRT522830)
- hsa-mir-665 (MIRT625580)
- hsa-mir-4443 (MIRT625581)
- hsa-mir-516b-5p (MIRT625582)
- hsa-mir-623 (MIRT625583)
- hsa-mir-650 (MIRT625584)
- hsa-mir-3612 (MIRT625585)
- hsa-mir-7160-5p (MIRT625586)
- hsa-mir-4722-5p (MIRT625587)
- hsa-mir-6884-5p (MIRT625588)
- hsa-mir-485-5p (MIRT625589)
- hsa-mir-1827 (MIRT625590)
- hsa-mir-4649-3p (MIRT625591)
- hsa-mir-6780b-3p (MIRT625592)
- hsa-mir-4780 (MIRT625593)
- hsa-mir-4768-3p (MIRT625594)
- hsa-mir-5690 (MIRT625595)
- hsa-mir-6866-3p (MIRT625596)
- hsa-mir-188-5p (MIRT625597)
- hsa-mir-4478 (MIRT625598)
- hsa-mir-4419b (MIRT625599)
- hsa-mir-3929 (MIRT625600)
- hsa-mir-940 (MIRT625601)
- hsa-mir-6893-5p (MIRT625602)
- hsa-mir-6808-5p (MIRT625603)
- hsa-mir-3664-5p (MIRT625604)
- hsa-mir-514a-5p (MIRT625605)
- hsa-mir-4714-5p (MIRT625606)
- hsa-mir-7977 (MIRT639273)
- hsa-mir-4540 (MIRT639274)
- hsa-mir-6723-5p (MIRT639275)
- hsa-mir-2114-5p (MIRT639276)
- hsa-mir-5588-3p (MIRT639277)
- hsa-mir-3924 (MIRT708079)
- hsa-mir-4666a-5p (MIRT708080)
- hsa-mir-466 (MIRT708081)
- hsa-mir-892a (MIRT708082)
- hsa-mir-574-5p (MIRT708083)
- hsa-mir-6867-5p (MIRT708084)
miRNA Products
- Search ViGene Biosciences for KLHL23
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for KLHL23
- Browse OriGene Inhibitory RNA Products For KLHL23
- genomics-online: shRNA clones - Search results for 96 available KLHL23 gene related products
- Overview of 96 available KLHL23 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KLHL23 gene
Clone Products
- Sino Biological Human cDNA Clone for KLHL23
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KLHL23
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLHL23
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for KLHL23
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KLHL23
-
ViGene Biosciences adenoviral particle packaged cDNA for KLHL23 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for KLHL23 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KLHL23 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL23 Gene
Localization for KLHL23 Gene
- Actin filaments (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0031463 | Cul3-RING ubiquitin ligase complex | IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL23 Gene
Pathways & Interactions for KLHL23 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vitamin B6 metabolism |
Pathways by source for KLHL23 Gene
1 BioSystems pathway for KLHL23 Gene
Interacting Proteins for KLHL23 Gene
Selected Interacting proteins:
ENSP00000272797
Q8NBE8-KLH23_HUMAN
for KLHL23 Gene via
STRING
IID
MINT
UniProtKB
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016567 | protein ubiquitination | IEA | -- |
No data available for SIGNOR curated interactions for KLHL23 Gene
Transcripts for KLHL23 Gene
mRNA/cDNA for KLHL23 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (82) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for KLHL23 Gene
- Kelch-like family member 23:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for KLHL23
- genomics-online: gRNA clones - Search results for 96 available KLHL23 gene related products
- Overview of 96 available KLHL23 gene related products
- Applied Biological Materials CRISPR for KLHL23
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLHL23
- GenScript: Design CRISPR guide RNA sequences for KLHL23
miRNA Products
- Search ViGene Biosciences for KLHL23
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for KLHL23
- Browse OriGene Inhibitory RNA Products For KLHL23
- genomics-online: shRNA clones - Search results for 96 available KLHL23 gene related products
- Overview of 96 available KLHL23 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KLHL23 gene
Clone Products
- Sino Biological Human cDNA Clone for KLHL23
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for KLHL23
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLHL23
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for KLHL23
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KLHL23 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL23 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of KLHL23 Gene:
KLHL23SOURCE GeneReport for Unigene cluster for KLHL23 Gene:
Hs.655150Evidence on tissue expression from TISSUES for KLHL23 Gene
- Nervous system(4.2)
- Eye(4)
Primer Products
-
OriGene qPCR primer pairs for KLHL23
-
OriGene qPCR primer pairs and template standards for KLHL23
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL23 Gene
Orthologs for KLHL23 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | KLHL23 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | KLHL23 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | KLHL23 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Klhl23 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | KLHL23 34 |
|
OneToOne | |
rat (Rattus norvegicus) |
Mammalia | Klhl23 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | KLHL23 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | KLHL23 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | KLHL23 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | klhl23 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | klhl23 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for KLHL23 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for KLHL23 Gene
Paralogs for KLHL23 Gene
(17) SIMAP similar genes for KLHL23 Gene using alignment to 6 proteins:
Variants for KLHL23 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000065296 | -- | 169,734,341(+) | C/G | intron_variant | |
rs1000069295 | -- | 169,746,863(+) | C/A | intron_variant | |
rs1000177785 | -- | 169,740,281(+) | T/G | intron_variant | |
rs1000280247 | -- | 169,737,551(+) | C/T | intron_variant | |
rs1000332388 | -- | 169,737,294(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1586748 | CNV | insertion | 17803354 |
esv1784706 | CNV | insertion | 17803354 |
esv2721119 | CNV | deletion | 23290073 |
nsv1007492 | CNV | gain | 25217958 |
nsv1011368 | CNV | loss | 25217958 |
nsv10201 | CNV | loss | 18304495 |
nsv1072045 | CNV | deletion | 25765185 |
nsv583606 | CNV | loss | 21841781 |
nsv583607 | CNV | gain | 21841781 |
nsv834454 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
9.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.33;
26.39% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLHL23 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KLHL23
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL23 Gene
Disorders for KLHL23 Gene
Additional Disease Information for KLHL23
No disorders were found for KLHL23 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL23 Gene
Publications for KLHL23 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 58
Products for KLHL23 Gene
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- Invitrogen Antibodies for KLHL23
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for KLHL23
- VectorBuilder custom plasmid, inducible vectors for KLHL23
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLHL23
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available KLHL23 related products ranked by validation data
- antibodies-online: Search results for available KLHL23 related products ranked by validation data
- antibodies-online: Search results for available KLHL23 related products ranked by validation data
- GeneTex KLHL23 antibody for KLHL23
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- ViGene Biosciences adenoviral particle packaged cDNA for KLHL23 gene
- ViGene Biosciences lentiviral particle packaged cDNA for KLHL23 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KLHL23 gene
- Search ViGene Biosciences for KLHL23
- Horizon Cell Lines for KLHL23
- genomics-online: cdna clones - Search results for 96 available KLHL23 gene related products
- Overview of 96 available KLHL23 gene related products
- orf clones - Search results for 96 available KLHL23 gene related products
- Overview of 96 available KLHL23 gene related products
- genomics-online: gRNA clones - Search results for 96 available KLHL23 gene related products
- Overview of 96 available KLHL23 gene related products
- genomics-online: primer clones - Search results for 96 available KLHL23 gene related products
- Overview of 96 available KLHL23 gene related products
- genomics-online: shRNA clones - Search results for 96 available KLHL23 gene related products
- Overview of 96 available KLHL23 gene related products
Sources for KLHL23 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
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