KLHL23 Gene
protein-coding GIFtS: 44
GCID: GC02P170551
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kelch-like family member 23(Previous name: kelch-like 23 (Drosophila) )
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Aliases
for KLHL23 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 231 2 | | Kelch-Like 23 (Drosophila)1 | | FLJ378121 | | DITHP2 | | MGC226791 | | Kelch-Like 232 | | MGC26101 | | Kelch-Like Protein 232 |
Export aliases for KLHL23 gene to outside databasesPrevious GC identifers: GC02P170417 GC02P170260 GC02P162442 |
Summaries
for KLHL23 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLHL23 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL23 gene promoter:
CREB FOXF2 HSF2 FOXO1a IRF-1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) HNF-3beta POU3F2 FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL23
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL23 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q31.1 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q31.1KLHL23 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P170551: view genomic region
(about GC identifiers)
Start:
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170,550,998 bp from pter |
End:
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170,633,499 bp from pter |
Size:
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82,502 bases |
Orientation:
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plus strand |
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Proteins
for KLHL23 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLH23_HUMAN, Q8NBE8 (See
protein sequence)Recommended Name: Kelch-like protein 23 Size: 558 amino acids; 63923 Da
Sequence caution: Sequence=BAC04490.1; Type=Erroneous initiation;
Secondary accessions: Q8N9B9 Q96FT8Explore the universe of human proteins at neXtProt for KLHL23: NX_Q8NBE8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NBE8
KLHL23 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653312.2
ENSEMBL proteins: ENSP00000272797 ENSP00000376419 ENSP00000394732 ENSP00000400833
Human Recombinant Protein Products:
KLHL23 Antibody Products:
Assay Products for KLHL23: |
Protein
Domains /
Families
for KLHL23 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHL23 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8NBE8ProtoNet protein and cluster: Q8NBE8 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KLH23_HUMAN, Q8NBE8Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats |
Function
for KLHL23 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL23 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLHL23 (NM_144711) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL23 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL23 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL23 |
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Pathways & Interactions
for KLHL23 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL23
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/6 Interacting proteins for KLHL23 (Q8NBE82, 3 ENSP000002727974) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
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Drugs & Compounds
for KLHL23 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL23
Search CenterWatch for drugs/clinical trials and news about KLHL23 / KLH23
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Transcripts
for KLHL23 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL23 gene: NM_144711.5 Unigene Cluster for KLHL23: Kelch-like 23 (Drosophila) Hs.655150 [show with all ESTs]Unigene Representative Sequence: NM_0011992906 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000498202 ENST00000272797 ENST00000392647(uc002ufh.2 uc002ufi.2)
ENST00000437875 ENST00000494387 ENST00000448589
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL23 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL23 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHL23 (NM_144711) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL23 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL23 |
Additional cDNA sequence: AK095131.1 AK123454.1 BC010437.1 BC012382.1 BC016950.1 5 DOTS entries: DT.75139201 DT.422027 DT.95253930 DT.65288454 DT.97822293 24/82 AceView cDNA sequences (see all 82): BM762290 AA610474 BQ229603 BM820383 AW117330 AW592552 AA883515 AA348884 AA918024 AK090653 AI304487 AA774547 BG029072 AI691127 BM763772 AX746559 AI018553 AA348620 BQ879272 BG106656 BX500650 AI139809 CR602210 AI286028
GeneLoc Exon Structure
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Expression
for KLHL23 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL23 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAAGGTAA
About this image
See KLHL23 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL23
SOURCE GeneReport for Unigene cluster: Hs.655150
SABiosciences Custom PCR Arrays for KLHL23
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL23
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL23 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL23 |
Orthologs
for KLHL23 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KLHL23 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for KLHL23 (if available)
TreeFam Gene Tree for KLHL23 (if available) |
Paralogs
for KLHL23 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL23 gene
- PHOSPHO2-KLHL23 KLHL382 KLHL212 KLHL292 KLHL62 KBTBD32 KLHL112 KLHL242
- KLHL252 KLHL302 KLHL352 ENC12 CCIN2
17 SIMAP similar genes for KLHL23 using alignment to 4 protein entries: KLH23_HUMAN (see all proteins):KBTBD3 KLHL17 KLHL20 KLHL13 ENC1 KLHL25
KLHL5 KLHL1 KLHL10 KLHL2 KLHL24 KLHL6
KLHL3 KLHL38 KLHL12 KLHL21 KLHL30
KLHL23 for paralogs About GeneDecksing
|
Genomic Variants
for KLHL23 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for KLHL23 (170550998 - 170633499 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLHL23: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL23 |
|
Disorders
/ Diseases
for KLHL23 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLHL23 for disorders About GeneDecksing
1  disease for KLHL23: About MalaCardscone-rod dystrophy
1 disease from the University of Copenhagen DISEASES database for KLHL23:cone-rod dystrophy Export disorders for KLHL23 gene to outside databases
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Publications
for KLHL23 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL23 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHL23) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Downregulation of two novel genes in Sl/Sld and W(LacZ)/Wv mouse jejunum. (PubMed id 16765319)1 Wouters M.M....Smans K.A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
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External Searches for KLHL23 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing KLHL23 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL23 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHL23 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL23 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for KLHL23 gene:
Search GeneIP for patents involving KLHL23
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL23 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL23 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL23 | | | OriGene Protein Over-expression Lysate for KLHL23 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for KLHL23 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL23 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL23 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KLHL23 | | OriGene Custom Protein Services for KLHL23 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL23 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL23 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL23 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL23 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL23 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL23 |
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| | | | Search Tocris compounds for KLHL23 |
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 | | | KLHL23 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL23 |
|  |  |  | | | | ThermoFisher Antibody for KLHL23 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL23 |
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