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Aliases for KLHL23 Gene

Aliases for KLHL23 Gene

  • Kelch Like Family Member 23 2 3 5
  • Kelch-Like Family Member 23 3
  • Kelch-Like 23 (Drosophila) 2
  • Kelch-Like 23 3
  • DITHP 3

External Ids for KLHL23 Gene

Previous GeneCards Identifiers for KLHL23 Gene

  • GC02P170417
  • GC02P170260
  • GC02P170551
  • GC02P162442

Summaries for KLHL23 Gene

GeneCards Summary for KLHL23 Gene

KLHL23 (Kelch Like Family Member 23) is a Protein Coding gene. Among its related pathways are Vitamin B6 metabolism. An important paralog of this gene is KBTBD4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL23 Gene

Genomics for KLHL23 Gene

Regulatory Elements for KLHL23 Gene

Enhancers for KLHL23 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL23 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL23 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL23 Gene

169,694,488 bp from pter
169,776,989 bp from pter
82,502 bases
Plus strand

Genomic View for KLHL23 Gene

Genes around KLHL23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL23 Gene

Proteins for KLHL23 Gene

  • Protein details for KLHL23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 23
    Protein Accession:
    Secondary Accessions:
    • Q8N9B9
    • Q96FT8

    Protein attributes for KLHL23 Gene

    558 amino acids
    Molecular mass:
    63923 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04490.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KLHL23 Gene

Proteomics data for KLHL23 Gene at MOPED

Post-translational modifications for KLHL23 Gene

  • Ubiquitination at Lys 251 and Lys 265
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL23 Gene

No data available for DME Specific Peptides for KLHL23 Gene

Domains & Families for KLHL23 Gene

Gene Families for KLHL23 Gene

Suggested Antigen Peptide Sequences for KLHL23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL23: view

Function for KLHL23 Gene

Gene Ontology (GO) - Molecular Function for KLHL23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL23: view

Phenotypes for KLHL23 Gene

genes like me logo Genes that share phenotypes with KLHL23: view

Animal Model Products

miRNA for KLHL23 Gene

miRTarBase miRNAs that target KLHL23

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL23 Gene

Localization for KLHL23 Gene

Subcellular locations from

Jensen Localization Image for KLHL23 Gene COMPARTMENTS Subcellular localization image for KLHL23 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL23 Gene

Pathways & Interactions for KLHL23 Gene

SuperPathways for KLHL23 Gene

Superpath Contained pathways
1 Vitamin B6 metabolism
genes like me logo Genes that share pathways with KLHL23: view

Pathways by source for KLHL23 Gene

1 BioSystems pathway for KLHL23 Gene

Gene Ontology (GO) - Biological Process for KLHL23 Gene


No data available for SIGNOR curated interactions for KLHL23 Gene

Drugs & Compounds for KLHL23 Gene

No Compound Related Data Available

Transcripts for KLHL23 Gene

Unigene Clusters for KLHL23 Gene

Kelch-like family member 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL23 Gene

No ASD Table

Relevant External Links for KLHL23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL23 Gene

mRNA expression in normal human tissues for KLHL23 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLHL23 Gene

SOURCE GeneReport for Unigene cluster for KLHL23 Gene Hs.655150

genes like me logo Genes that share expression patterns with KLHL23: view

Protein tissue co-expression partners for KLHL23 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL23 Gene

Orthologs for KLHL23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL23 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL23 35
  • 94.09 (n)
  • 98.39 (a)
KLHL23 36
  • 98 (a)
(Canis familiaris)
Mammalia KLHL23 35
  • 94.03 (n)
  • 98.57 (a)
KLHL23 36
  • 99 (a)
(Mus musculus)
Mammalia Klhl23 35
  • 90.2 (n)
  • 97.13 (a)
Klhl23 36
  • 97 (a)
(Pan troglodytes)
Mammalia KLHL23 35
  • 99.82 (n)
  • 99.82 (a)
KLHL23 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhl23 35
  • 89.21 (n)
  • 96.94 (a)
(Monodelphis domestica)
Mammalia KLHL23 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL23 36
  • 80 (a)
(Gallus gallus)
Aves KLHL23 35
  • 71.48 (n)
  • 73.3 (a)
KLHL23 36
  • 74 (a)
(Anolis carolinensis)
Reptilia KLHL23 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl23 35
  • 68.94 (n)
  • 71.15 (a)
(Danio rerio)
Actinopterygii klhl23 35
  • 64.09 (n)
  • 60.61 (a)
klhl23 36
  • 61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for KLHL23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL23 Gene

Gene Tree for KLHL23 (if available)
Gene Tree for KLHL23 (if available)

Paralogs for KLHL23 Gene

genes like me logo Genes that share paralogs with KLHL23: view

Variants for KLHL23 Gene

Structural Variations from Database of Genomic Variants (DGV) for KLHL23 Gene

Variant ID Type Subtype PubMed ID
nsv834454 CNV Loss 17160897
nsv10201 CNV Loss 18304495
esv2721119 CNV Deletion 23290073
esv1784706 CNV Insertion 17803354
esv1586748 CNV Insertion 17803354

Variation tolerance for KLHL23 Gene

Residual Variation Intolerance Score: 9.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for KLHL23 Gene

Disorders for KLHL23 Gene

Relevant External Links for KLHL23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL23 Gene

Publications for KLHL23 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KLHL23 Gene

Sources for KLHL23 Gene