Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLHL22 Gene

Aliases for KLHL22 Gene

  • Kelch Like Family Member 22 2 3 5
  • Kelch-Like Family Member 22 3
  • Kelch-Like 22 (Drosophila) 2
  • Kelch-Like 22 3
  • KELCHL 3

External Ids for KLHL22 Gene

Previous GeneCards Identifiers for KLHL22 Gene

  • GC22M019122
  • GC22M020783
  • GC22M004059

Summaries for KLHL22 Gene

GeneCards Summary for KLHL22 Gene

KLHL22 (Kelch Like Family Member 22) is a Protein Coding gene. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL22 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL22 Gene

Genomics for KLHL22 Gene

Regulatory Elements for KLHL22 Gene

Enhancers for KLHL22 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL22 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL22 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL22 Gene

Chromosome:
22
Start:
20,441,519 bp from pter
End:
20,495,883 bp from pter
Size:
54,365 bases
Orientation:
Minus strand

Genomic View for KLHL22 Gene

Genes around KLHL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL22 Gene

Proteins for KLHL22 Gene

  • Protein details for KLHL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53GT1-KLH22_HUMAN
    Recommended name:
    Kelch-like protein 22
    Protein Accession:
    Q53GT1
    Secondary Accessions:
    • A8K3Q4
    • A8MTV3
    • B7Z2G1
    • D3DX30
    • Q96B68
    • Q96KC6

    Protein attributes for KLHL22 Gene

    Size:
    634 amino acids
    Molecular mass:
    71667 Da
    Quaternary structure:
    • Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1. Interacts with PLK1.
    SequenceCaution:
    • Sequence=BAB55007.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL22 Gene

Proteomics data for KLHL22 Gene at MOPED

Post-translational modifications for KLHL22 Gene

  • Ubiquitination at Lys 12, Lys 329, and Lys 433
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL22 Gene

Antibody Products

No data available for DME Specific Peptides for KLHL22 Gene

Domains & Families for KLHL22 Gene

Gene Families for KLHL22 Gene

Suggested Antigen Peptide Sequences for KLHL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53GT1

UniProtKB/Swiss-Prot:

KLH22_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL22: view

Function for KLHL22 Gene

Molecular function for KLHL22 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

Gene Ontology (GO) - Molecular Function for KLHL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL22: view
genes like me logo Genes that share phenotypes with KLHL22: view

Animal Model Products

miRNA for KLHL22 Gene

miRTarBase miRNAs that target KLHL22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL22 Gene

Localization for KLHL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL22 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL22 Gene COMPARTMENTS Subcellular localization image for KLHL22 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLHL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IEA,IDA 19995937
genes like me logo Genes that share ontologies with KLHL22: view

Pathways & Interactions for KLHL22 Gene

SuperPathways for KLHL22 Gene

No Data Available

UniProtKB/Swiss-Prot Q53GT1-KLH22_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KLHL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007094 mitotic spindle assembly checkpoint IMP 23455478
GO:0051301 cell division IEA,IMP 19995937
genes like me logo Genes that share ontologies with KLHL22: view

No data available for Pathways by source and SIGNOR curated interactions for KLHL22 Gene

Drugs & Compounds for KLHL22 Gene

No Compound Related Data Available

Transcripts for KLHL22 Gene

Unigene Clusters for KLHL22 Gene

Kelch-like family member 22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL22 Gene

No ASD Table

Relevant External Links for KLHL22 Gene

GeneLoc Exon Structure for
KLHL22
ECgene alternative splicing isoforms for
KLHL22

Expression for KLHL22 Gene

mRNA expression in normal human tissues for KLHL22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL22 Gene

This gene is overexpressed in Testis (8.6) and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL22 Gene



SOURCE GeneReport for Unigene cluster for KLHL22 Gene Hs.517419

genes like me logo Genes that share expression patterns with KLHL22: view

Protein tissue co-expression partners for KLHL22 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL22 Gene

Orthologs for KLHL22 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHL22 35
  • 86.86 (n)
  • 94.16 (a)
KLHL22 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL22 35
  • 90.75 (n)
  • 98.42 (a)
KLHL22 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl22 35
  • 87.28 (n)
  • 94.64 (a)
Klhl22 16
Klhl22 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHL22 35
  • 99.64 (n)
  • 99.82 (a)
KLHL22 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl22 35
  • 87.38 (n)
  • 95.11 (a)
oppossum
(Monodelphis domestica)
Mammalia KLHL22 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL22 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL22 35
  • 72.4 (n)
  • 78.55 (a)
KLHL22 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl22 35
  • 66.61 (n)
  • 69.56 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100333714 35
  • 62.66 (n)
  • 61.35 (a)
klhl22 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7057 35
fruit fly
(Drosophila melanogaster)
Insecta CG1812 35
  • 45.62 (n)
  • 30.12 (a)
CG1812 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for KLHL22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL22 Gene

ENSEMBL:
Gene Tree for KLHL22 (if available)
TreeFam:
Gene Tree for KLHL22 (if available)

Paralogs for KLHL22 Gene

genes like me logo Genes that share paralogs with KLHL22: view

Variants for KLHL22 Gene

Sequence variations from dbSNP and Humsavar for KLHL22 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs8353 -- 20,441,830(+) GGAAG(G/T)CCAAA nc-transcript-variant, utr-variant-3-prime
rs8748 -- 20,446,548(+) GGCCC(A/G)TCAGC nc-transcript-variant, reference, synonymous-codon
rs9997 -- 20,441,888(+) CTGCA(C/T)GGCCC nc-transcript-variant, utr-variant-3-prime
rs2108742 -- 20,453,260(+) ttctt(C/T)ttttt intron-variant
rs2287256 -- 20,441,639(+) CTCTG(C/T)TCCTC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL22 Gene

Variant ID Type Subtype PubMed ID
nsv518950 CNV Gain 19592680
nsv436867 CNV Insertion 17901297
nsv436864 CNV Insertion 17901297
nsv828954 CNV Gain 20364138
nsv914390 CNV Gain 21882294
dgv4867n71 CNV Gain 21882294
nsv914393 CNV Gain 21882294
nsv834135 CNV Gain 17160897
nsv834136 CNV Loss 17160897
dgv4868n71 CNV Loss 21882294
nsv509809 CNV Insertion 20534489
nsv523162 CNV Loss 19592680
nsv834138 CNV Loss 17160897
nsv914400 CNV Loss 21882294
nsv3561 CNV Insertion 18451855
nsv509810 CNV Insertion 20534489

Variation tolerance for KLHL22 Gene

Residual Variation Intolerance Score: 4.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL22 Gene

HapMap Linkage Disequilibrium report
KLHL22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL22 Gene

Disorders for KLHL22 Gene

Relevant External Links for KLHL22

Genetic Association Database (GAD)
KLHL22
Human Genome Epidemiology (HuGE) Navigator
KLHL22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL22

No disorders were found for KLHL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL22 Gene

Publications for KLHL22 Gene

  1. Ubiquitylation-dependent localization of PLK1 in mitosis. (PMID: 23455478) Beck J. … Sumara I. (Nat. Cell Biol. 2013) 3 4 67
  2. CUL3 and protein kinases: insights from PLK1/KLHL22 interaction. (PMID: 24067371) Metzger T. … Sumara I. (Cell Cycle 2013) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. Genome-wide association study of retinopathy in individuals without diabetes. (PMID: 23393555) Jensen R.A. … Wong T.Y. (PLoS ONE 2013) 3
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3

Products for KLHL22 Gene

Sources for KLHL22 Gene

Content