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Aliases for KLHL22 Gene

Aliases for KLHL22 Gene

  • Kelch Like Family Member 22 2 3 5
  • Kelch-Like 22 (Drosophila) 2
  • Kelch-Like Protein 22 3
  • Kelch-Like 22 3
  • KELCHL 3

External Ids for KLHL22 Gene

Previous GeneCards Identifiers for KLHL22 Gene

  • GC22M019122
  • GC22M020783
  • GC22M004059

Summaries for KLHL22 Gene

GeneCards Summary for KLHL22 Gene

KLHL22 (Kelch Like Family Member 22) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL22 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL22 Gene

Genomics for KLHL22 Gene

Regulatory Elements for KLHL22 Gene

Enhancers for KLHL22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G020548 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -58.0 -58032 10.5 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A YBX1 MED15 SCARF2 LOC100420177 THAP7 PI4KA THAP7-AS1 ENSG00000236003 ABHD17AP4 KLHL22 DGCR8
GH22G020543 1.6 Ensembl ENCODE dbSUPER 11.6 -49.7 -49679 3.6 HDGF PKNOX1 CREB3L1 ARNT ZNF766 KLF13 MCM3 ZNF592 MEF2D SREBF1 MED15 SCARF2 ABHD17AP4 KLHL22 RNU6-225P SERPIND1 ZNF74 ENSG00000236003 CCDC74BP1
GH22G020576 1.1 ENCODE dbSUPER 11.2 -81.0 -81012 1.3 HDAC1 BCOR HDGF CTCF RB1 HINFP ZMYM3 ZIC2 ZFHX2 GATA2 MED15 ENSG00000236003 KLHL22 PI4KA SERPIND1 ZNF74 CCDC74BP1
GH22G020462 1 Ensembl ENCODE 12 +31.9 31854 2.8 HDAC1 KLF1 TSC22D4 YBX1 ZNF384 RBBP5 RELA POLR2A KDM5B PRDM10 MED15 SCARF2 RNU6-225P KLHL22 ABHD17AP4 ZNF74 USP41 ENSG00000236003 LZTR1 RNY1P9
GH22G020582 0.9 dbSUPER 11.2 -87.8 -87812 2.1 HDGF HNRNPUL1 PKNOX1 TBL1XR1 AGO1 RAD21 EGR1 PRPF4 KLF13 CREM MED15 DGCR8 RPL7AP70 THAP7 ENSG00000236003 KLHL22 PI4KA SERPIND1 RPL8P5 TBX1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL22 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143902 83 2001 CREB3L1 FEZF1 YBX1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 SP3 MEF2D

Genomic Location for KLHL22 Gene

Chromosome:
22
Start:
20,441,519 bp from pter
End:
20,495,883 bp from pter
Size:
54,365 bases
Orientation:
Minus strand

Genomic View for KLHL22 Gene

Genes around KLHL22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL22 Gene

Proteins for KLHL22 Gene

  • Protein details for KLHL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53GT1-KLH22_HUMAN
    Recommended name:
    Kelch-like protein 22
    Protein Accession:
    Q53GT1
    Secondary Accessions:
    • A8K3Q4
    • A8MTV3
    • B7Z2G1
    • D3DX30
    • Q96B68
    • Q96KC6

    Protein attributes for KLHL22 Gene

    Size:
    634 amino acids
    Molecular mass:
    71667 Da
    Quaternary structure:
    • Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1. Interacts with PLK1.
    SequenceCaution:
    • Sequence=BAB55007.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL22 Gene

Post-translational modifications for KLHL22 Gene

  • Ubiquitination at posLast=1212, posLast=329329, and isoforms=3433
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KLHL22 Gene

Domains & Families for KLHL22 Gene

Gene Families for KLHL22 Gene

Suggested Antigen Peptide Sequences for KLHL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL22: view

No data available for UniProtKB/Swiss-Prot for KLHL22 Gene

Function for KLHL22 Gene

Molecular function for KLHL22 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

Gene Ontology (GO) - Molecular Function for KLHL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 23455478
genes like me logo Genes that share ontologies with KLHL22: view
genes like me logo Genes that share phenotypes with KLHL22: view

Animal Model Products

CRISPR Products

miRNA for KLHL22 Gene

miRTarBase miRNAs that target KLHL22

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL22 Gene

Localization for KLHL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL22 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL22 gene
Compartment Confidence
cytoskeleton 5
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 23455478
GO:0005813 centrosome IDA 23455478
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle IEA --
GO:0005827 polar microtubule IDA 23455478
genes like me logo Genes that share ontologies with KLHL22: view

Pathways & Interactions for KLHL22 Gene

genes like me logo Genes that share pathways with KLHL22: view

UniProtKB/Swiss-Prot Q53GT1-KLH22_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KLHL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 23455478
GO:0006513 protein monoubiquitination IDA 23455478
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint IMP 23455478
genes like me logo Genes that share ontologies with KLHL22: view

No data available for SIGNOR curated interactions for KLHL22 Gene

Drugs & Compounds for KLHL22 Gene

No Compound Related Data Available

Transcripts for KLHL22 Gene

Unigene Clusters for KLHL22 Gene

Kelch-like family member 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL22 Gene

No ASD Table

Relevant External Links for KLHL22 Gene

GeneLoc Exon Structure for
KLHL22
ECgene alternative splicing isoforms for
KLHL22

Expression for KLHL22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL22 Gene

This gene is overexpressed in Testis (8.6) and Fetal Brain (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHL22 Gene



Protein tissue co-expression partners for KLHL22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLHL22 Gene:

KLHL22

SOURCE GeneReport for Unigene cluster for KLHL22 Gene:

Hs.517419

Evidence on tissue expression from TISSUES for KLHL22 Gene

  • Nervous system(4.8)
  • Kidney(4.2)
  • Liver(4.1)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with KLHL22: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL22 Gene

Orthologs for KLHL22 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL22 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia KLHL22 34 35
  • 90.75 (n)
rat
(Rattus norvegicus)
Mammalia Klhl22 34
  • 87.38 (n)
mouse
(Mus musculus)
Mammalia Klhl22 34 16 35
  • 87.28 (n)
cow
(Bos Taurus)
Mammalia KLHL22 34 35
  • 86.86 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL22 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL22 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL22 34 35
  • 72.4 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl22 34
  • 66.61 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333714 34
  • 62.66 (n)
klhl22 35
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7057 34
fruit fly
(Drosophila melanogaster)
Insecta CG1812 34 35
  • 45.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for KLHL22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL22 Gene

ENSEMBL:
Gene Tree for KLHL22 (if available)
TreeFam:
Gene Tree for KLHL22 (if available)

Paralogs for KLHL22 Gene

Variants for KLHL22 Gene

Sequence variations from dbSNP and Humsavar for KLHL22 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000108991 -- 20,480,884(+) TGGAA(G/T)GCAGT intron-variant
rs1000110972 -- 20,444,119(+) GGACT(C/T)AACCT intron-variant
rs1000137524 -- 20,441,042(+) ACCTG(A/G)CAAAC intron-variant, downstream-variant-500B
rs1000186142 -- 20,481,666(+) CTTGG(C/T)TTGGC intron-variant
rs1000224527 -- 20,449,295(+) GACCT(C/T)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL22 Gene

Variant ID Type Subtype PubMed ID
dgv10n35 CNV novel sequence insertion 20440878
dgv4483n100 CNV gain 25217958
dgv7993n54 CNV gain 21841781
esv3647292 CNV gain 21293372
esv3893438 CNV gain 25118596
nsv1056614 CNV loss 25217958
nsv1109451 CNV deletion 24896259
nsv1123576 CNV deletion 24896259
nsv3561 CNV insertion 18451855
nsv436864 CNV insertion 17901297
nsv479206 CNV novel sequence insertion 20440878
nsv479247 CNV novel sequence insertion 20440878
nsv509809 CNV insertion 20534489
nsv509810 CNV insertion 20534489
nsv523162 CNV loss 19592680
nsv588293 CNV gain 21841781
nsv828954 CNV gain 20364138
nsv834135 CNV gain 17160897
nsv834136 CNV loss 17160897
nsv834138 CNV loss 17160897
nsv953032 CNV deletion 24416366
nsv962758 CNV duplication 23825009
nsv966079 CNV duplication 23825009

Variation tolerance for KLHL22 Gene

Residual Variation Intolerance Score: 4.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL22 Gene

Disorders for KLHL22 Gene

Relevant External Links for KLHL22

Genetic Association Database (GAD)
KLHL22
Human Genome Epidemiology (HuGE) Navigator
KLHL22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL22

No disorders were found for KLHL22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL22 Gene

Publications for KLHL22 Gene

  1. CUL3 and protein kinases: insights from PLK1/KLHL22 interaction. (PMID: 24067371) Metzger T. … Sumara I. (Cell Cycle 2013) 2 3 64
  2. Ubiquitylation-dependent localization of PLK1 in mitosis. (PMID: 23455478) Beck J. … Sumara I. (Nat. Cell Biol. 2013) 3 4 64
  3. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PMID: 19995937) Maerki S. … Peter M. (J. Cell Biol. 2009) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64

Products for KLHL22 Gene

Sources for KLHL22 Gene

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