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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL22 Gene

protein-coding   GIFtS: 47
GCID: GC22M020783

kelch-like family member 22

(Previous name: kelch-like 22 (Drosophila) )
  Search for KLHL22
in
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 Human Malady Compendium 
Biological research products
for KLHL22    

Aliases
for KLHL22 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Kelch-Like Family Member 221 2
KELCHL1 2
FLJ143601
Kelch-Like 22 (Drosophila)1
Kelch-Like 222
Kelch-Like Protein 222

External Ids:    HGNC: 258881   Entrez Gene: 848612   Ensembl: ENSG000000999107   UniProtKB: Q53GT13   
ORGUL members:         
NONCODE:n409440    

Export aliases for KLHL22 gene to outside databases

Previous GC identifers: GC22M019122 GC22M004059


Summaries
for KLHL22 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: KLH22_HUMAN, Q53GT1
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for cell division.
BCR E3 ubiquitin ligase complexes mediate the ubiquitination of target proteins




Genomic Views
for KLHL22 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL22 gene promoter:
         SRF   SRF (504 AA)   Lmo2   Ik-3   POU2F1   NRF-2   FOXO4   POU2F1a   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KLHL22

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

KLHL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL22 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M020783:  view genomic region     (about GC identifiers)

Start:
 20,783,528 bp from pter      End:
 20,850,170 bp from pter
Size:
 66,643 bases      Orientation:
 minus strand

Proteins
for KLHL22 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KLH22_HUMAN, Q53GT1 (See protein sequence)
Recommended Name: Kelch-like protein 22  
Size: 634 amino acids; 71667 Da
Subunit: Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1
Sequence caution: Sequence=BAB55007.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: A8K3Q4 A8MTV3 D3DX30 Q96B68 Q96KC6

Explore the universe of human proteins at neXtProt for KLHL22: NX_Q53GT1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q53GT1

    • KLHL22 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_116164.2  
    ENSEMBL proteins: 
     ENSP00000392268   ENSP00000331682   ENSP00000400095   ENSP00000403999   ENSP00000398616  
     ENSP00000397882   ENSP00000409092   ENSP00000402746   ENSP00000405521  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: KLHL22
    OriGene Protein Over-expression Lysate: KLHL22
    OriGene Custom Protein Services for KLHL22 
    GenScript Custom Purified and Recombinant Proteins Services for KLHL22
    Novus Biologicals KLHL22 Protein
    Novus Biologicals KLHL22 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KLHL22

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031463Cul3-RING ubiquitin ligase complex IDA19995937


    KLHL22 for ontologies           About GeneDecksing



    KLHL22 Antibody Products: 
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    Uscn Antibodies for KLHL22
    ThermoFisher Antibodies for KLHL22

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    Uscn ELISAs and CLIAs for KLHL22

    Protein Domains /
    Families
    for KLHL22 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KLHL22 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017096 Kelch-like_gigaxonin
     IPR000210 BTB/POZ-like
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q53GT1

    ProtoNet protein and cluster: Q53GT1

    2 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH22_HUMAN, Q53GT1
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Function
    for KLHL22 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KLH22_HUMAN, Q53GT1
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for cell division.
    BCR E3 ubiquitin ligase complexes mediate the ubiquitination of target proteins

    miRNA
    Products:            		 OriGene 3'-UTR Clone: KLHL22
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL22
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL22 (see all 9):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-205* hsa-miR-20b hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmid: KLHL22 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL22 (see all 7)
    OriGene shRNA RFP: KLHL22
    OriGene siRNA: KLHL22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL22

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KLHL22

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL22 (see all 3)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL22 

    Cell Line
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    Search LifeMap BioReagents cell lines for KLHL22

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL22

    1 GenomeRNAi human phenotype for KLHL22:
     Decreased viability with pacli 


    Pathways & Interactions
    for KLHL22 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: KLH22_HUMAN, Q53GT1
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for KLHL22 (Q53GT13 ENSP000003316824) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    FAF1Q9UNN53, ENSP000003794574I2D: score=2 STRING: ENSP00000379457
    KLHL13Q9P2N73, ENSP000002628204I2D: score=2 STRING: ENSP00000262820
    UBXN1Q043233, ENSP000002941194I2D: score=2 STRING: ENSP00000294119
    UBXN7O948883, ENSP000002963284I2D: score=2 STRING: ENSP00000296328
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0051301cell division IMP19995937


    KLHL22 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KLHL22 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL22
    Search CenterWatch for drugs/clinical trials and news about KLHL22 / KLH22 

    Transcripts
    for KLHL22 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KLHL22 gene: 
    NM_032775.3  

    Unigene Cluster for KLHL22:

    Kelch-like 22 (Drosophila)
    Hs.517419  [show with all ESTs]
    Unigene Representative Sequence: AK024369
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000429594 ENST00000328879(uc002zsl.2 uc011ahr.2) ENST00000487090
    ENST00000479601 ENST00000451553 ENST00000444967 ENST00000458248 ENST00000443285
    ENST00000494929 ENST00000431430 ENST00000470335 ENST00000490556 ENST00000423364
    ENST00000440659

    miRNA
    Products:             		 OriGene 3'-UTR Clone: KLHL22
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL22
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL22 (see all 9):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-205* hsa-miR-20b hsa-miR-17
    SwitchGear 3'UTR luciferase reporter plasmid: KLHL22 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL22 (see all 7)
    OriGene shRNA RFP: KLHL22
    OriGene siRNA: KLHL22
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL22
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL22
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    GenScript: all cDNA clones in your preferred vector: KLHL22 (NM_032775)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL22 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL22
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL22
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL22
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL22

    Additional cDNA sequence: 

    AK024369.1 AK027266.1 AK222850.1 AK290669.1 AK294682.1 BC015923.1 CR456352.1 NR_033825.1 

    23 DOTS entries:

    DT.101977829  DT.100785509  DT.95112966  DT.110787  DT.75103855  DT.100794476  DT.100794478  DT.100785508 
    DT.97823228  DT.100844204  DT.120668491  DT.91653402  DT.101963487  DT.91779995  DT.100721512  DT.100794475 
    DT.100844616  DT.120668053  DT.92422114  DT.100000235  DT.75190219  DT.91918844  DT.92009127 

    24/354 AceView cDNA sequences (see all 354):

    BM691064 AW249671 AI365375 CR456352 AI701297 AW593304 AI467996 AI803662 
    AI127800 BM663110 AU119574 BI489030 AI312865 AI084861 AA256005 BQ898562 
    AA350442 BX371231 BX340267 CR610654 BM547673 BU622985 BM264532 AF088043 

    GeneLoc Exon Structure


    Expression
    for KLHL22 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGTTGGTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See KLHL22 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL22

    SOURCE GeneReport for Unigene cluster: Hs.517419
        SABiosciences Expression via Pathway-Focused PCR Array including KLHL22: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL22

    Orthologs
    for KLHL22 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KLHL22 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KLHL221 kelch-like 22 (Drosophila) 72.34(n)
    78.55(a)    		   416940  XM_415234.3  XP_415234.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 63(a)
    56(a)
    		 1 ↔ many
    1 ↔ many
    		 GL343376.1(903839-910818)
    GL343538.1(116948-128164)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003337141 kelch-like 13-like 62.66(n)
    61.35(a)    		   100333714  XM_003199151.1  XP_003199199.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG18121 CG1812 45.65(n)
    30.7(a)    		   33049  NM_134553.2  NP_608397.1 


    ENSEMBL Gene Tree for KLHL22 (if available)
    TreeFam Gene Tree for KLHL22 (if available) 

    Paralogs
    for KLHL22 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL22 gene
    KLHL422  KLHL132  KLHL262  KLHL342  KBTBD132  KBTBD112  KLHL312  KLHL92  
    KLHL322  KLHL142  KLHDC7B2  KLHL152  KLHL362  KLHL332  KLHDC7A2  
    18/24 SIMAP similar genes for KLHL22 using alignment to 9 protein entries:     KLH22_HUMAN (see all proteins) (see all similar genes):
    ZBTB7C    IVNS1ABP    KLHL32    KLHL1    KLHL36    ZBTB21
    ZBTB44    KLHL3    FLJ00127    KBTBD8    BTBD3    KLHL28
    KLHL26    DKFZp686L0695    KLHL9    KLHL5    KLHL15    MYNN

    KLHL22 for paralogs           About GeneDecksing



    Genomic Variants
    for KLHL22 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/936 NCBI SNPs in KLHL22 are shown (see all 936)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1882625601,2
    		--20795315(+) GGTGCC/GTAAGG 2 -- int1 ds50010--------
    rs738793731,2
    		C,--20795322(+) AAGGGT/CTACCT 2 -- int1 ds50012Minor allele frequency- C:0.04WA 120
    rs1820367421,2
    		--20795418(+) CCCCCA/CCACCG 2 -- int1 ds50010--------
    rs605748401,2
    		C,--20795420(+) CCCCCA/GCCGAC 2 -- ds5001 int13Minor allele frequency- G:0.41NA EA 242
    rs1863762781,2
    		--20795441(+) TGCCCC/TGCTCC 2 -- int1 ds50010--------
    rs622190321,2
    		C,--20795454(+) GGTGCT/CGAAGC 2 -- int1 ds50013Minor allele frequency- C:0.20NA WA 240
    rs1490449731,2
    		--20795733(+) CTGACA/CCCAGA 2 -- ds5001 int10--------
    rs11534271,2
    		C,F,A,H,--20795757(+) GGGGAC/TGCAGC 2 -- int1 ds500128Minor allele frequency- A:0.01EA NA NS WA CSA 3576
    rs1145668761,2
    		C,F,--20795858(+) ATGGGG/TTCTGA 2 -- nc-transcript-variantut311Minor allele frequency- T:0.03WA 118
    rs22872561,2
    		C,F,--20795926(+) CTCTGC/TTCCTC 2 -- nc-transcript-variantut311Minor allele frequency- T:0.05EA 120

    HapMap Linkage Disequilibrium report for KLHL22 (20783528 - 20850170 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for KLHL22
         3 CNVs: 31071 35983 5169

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL22
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL22

    Disorders / Diseases
    for KLHL22 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KLHL22 for disorders           About MalaCards

    KLHL22 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: KLHL22 (1 document)

    Export disorders for KLHL22 gene to outside databases

    Publications
    for KLHL22 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL22 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with KLHL22)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PubMed id 19995937)1, 2 Maerki S....Peter M. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    External Searches for KLHL22 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing KLHL22 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84861 HGNC: 25888 AceView: SCARF2andKELCHL Ensembl:ENSG00000099910 euGenes: HUgn84861
    ECgene: KLHL22 H-InvDB: KLHL22

    Other Databases showing KLHL22 gene

    (According to HUGE)
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    Specialized Databases showing KLHL22 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL22 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KLHL22 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for KLHL22 gene:
    Search GeneIP for patents involving KLHL22

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