Aliases for KLHL22 Gene
External Ids for KLHL22 Gene
Previous GeneCards Identifiers for KLHL22 Gene
GeneCards Summary for KLHL22 Gene
KLHL22 (Kelch-Like Family Member 22) is a Protein Coding gene. An important paralog of this gene is KLHL36.
UniProtKB/Swiss-Prot for KLHL22 Gene
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.