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Aliases for KLHL22 Gene

Aliases for KLHL22 Gene

  • Kelch-Like Family Member 22 2 3
  • Kelch-Like 22 (Drosophila) 2
  • Kelch-Like Protein 22 3
  • Kelch-Like 22 3
  • KELCHL 3

External Ids for KLHL22 Gene

Previous GeneCards Identifiers for KLHL22 Gene

  • GC22M019122
  • GC22M020783
  • GC22M004059

Summaries for KLHL22 Gene

GeneCards Summary for KLHL22 Gene

KLHL22 (Kelch-Like Family Member 22) is a Protein Coding gene. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL22 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL22 Gene

Genomics for KLHL22 Gene

Regulatory Elements for KLHL22 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL22 Gene

Start:
20,441,519 bp from pter
End:
20,495,883 bp from pter
Size:
54,365 bases
Orientation:
Minus strand

Genomic View for KLHL22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL22 Gene

Proteins for KLHL22 Gene

  • Protein details for KLHL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53GT1-KLH22_HUMAN
    Recommended name:
    Kelch-like protein 22
    Protein Accession:
    Q53GT1
    Secondary Accessions:
    • A8K3Q4
    • A8MTV3
    • B7Z2G1
    • D3DX30
    • Q96B68
    • Q96KC6

    Protein attributes for KLHL22 Gene

    Size:
    634 amino acids
    Molecular mass:
    71667 Da
    Quaternary structure:
    • Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1. Interacts with PLK1.
    SequenceCaution:
    • Sequence=BAB55007.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL22 Gene

Proteomics data for KLHL22 Gene at MOPED

Post-translational modifications for KLHL22 Gene

  • Ubiquitination at Lys12, Lys329, and Lys433
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL22 Gene

No data available for DME Specific Peptides for KLHL22 Gene

Domains for KLHL22 Gene

Gene Families for KLHL22 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53GT1

UniProtKB/Swiss-Prot:

KLH22_HUMAN :
  • Q53GT1
Domain:
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL22: view

Function for KLHL22 Gene

Molecular function for KLHL22 Gene

UniProtKB/Swiss-Prot Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.

Gene Ontology (GO) - Molecular Function for KLHL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455478
genes like me logo Genes that share ontologies with KLHL22: view

Phenotypes for KLHL22 Gene

GenomeRNAi human phenotypes for KLHL22:
genes like me logo Genes that share phenotypes with KLHL22: view

Animal Model Products

CRISPR Products

miRNA for KLHL22 Gene

miRTarBase miRNAs that target KLHL22

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL22 Gene

Localization for KLHL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL22 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL22 Gene COMPARTMENTS Subcellular localization image for KLHL22 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLHL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 23455478
GO:0005813 centrosome IDA 23455478
GO:0005827 polar microtubule IDA 23455478
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 19995937
GO:0072686 mitotic spindle IDA 23455478
genes like me logo Genes that share ontologies with KLHL22: view

Pathways for KLHL22 Gene

SuperPathways for KLHL22 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q53GT1-KLH22_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for KLHL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IMP 23455478
GO:0006513 protein monoubiquitination IDA 23455478
GO:0007094 mitotic spindle assembly checkpoint IMP 23455478
GO:0051301 cell division IMP 19995937
genes like me logo Genes that share ontologies with KLHL22: view

No data available for Pathways by source for KLHL22 Gene

Transcripts for KLHL22 Gene

Unigene Clusters for KLHL22 Gene

Kelch-like family member 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL22

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL22 Gene

No ASD Table

Relevant External Links for KLHL22 Gene

GeneLoc Exon Structure for
KLHL22
ECgene alternative splicing isoforms for
KLHL22

Expression for KLHL22 Gene

mRNA expression in normal human tissues for KLHL22 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL22 Gene

SOURCE GeneReport for Unigene cluster for KLHL22 Gene Hs.517419

genes like me logo Genes that share expressions with KLHL22: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL22 Gene

Orthologs for KLHL22 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL22 35
  • 99.64 (n)
  • 99.82 (a)
KLHL22 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHL22 35
  • 86.86 (n)
  • 94.16 (a)
KLHL22 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL22 35
  • 90.75 (n)
  • 98.42 (a)
KLHL22 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl22 35
  • 87.28 (n)
  • 94.64 (a)
Klhl22 16
Klhl22 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL22 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL22 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl22 35
  • 87.38 (n)
  • 95.11 (a)
chicken
(Gallus gallus)
Aves KLHL22 35
  • 72.4 (n)
  • 78.55 (a)
KLHL22 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl22 35
  • 66.61 (n)
  • 69.56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7057 35
zebrafish
(Danio rerio)
Actinopterygii klhl22 36
  • 60 (a)
OneToOne
LOC100333714 35
  • 62.66 (n)
  • 61.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1812 35
  • 45.62 (n)
  • 30.12 (a)
CG1812 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for KLHL22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL22 Gene

ENSEMBL:
Gene Tree for KLHL22 (if available)
TreeFam:
Gene Tree for KLHL22 (if available)

Paralogs for KLHL22 Gene

genes like me logo Genes that share paralogs with KLHL22: view

Variants for KLHL22 Gene

Sequence variations from dbSNP and Humsavar for KLHL22 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs8353 -- 20,441,830(+) GGAAG(G/T)CCAAA utr-variant-3-prime, nc-transcript-variant
rs8748 -- 20,446,548(+) GGCCC(A/G)TCAGC synonymous-codon, reference, nc-transcript-variant
rs9997 -- 20,441,888(+) CTGCA(C/T)GGCCC utr-variant-3-prime, nc-transcript-variant
rs98399 -- 20,463,817(+) GGCCA(A/G)CAGTA intron-variant
rs165613 -- 20,489,598(+) CAATT(G/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL22 Gene

Variant ID Type Subtype PubMed ID
nsv518950 CNV Gain 19592680
nsv436867 CNV Insertion 17901297
nsv436864 CNV Insertion 17901297
nsv828954 CNV Gain 20364138
nsv914390 CNV Gain 21882294
dgv4867n71 CNV Gain 21882294
nsv914393 CNV Gain 21882294
nsv834135 CNV Gain 17160897
nsv834136 CNV Loss 17160897
dgv4868n71 CNV Loss 21882294
nsv509809 CNV Insertion 20534489
nsv523162 CNV Loss 19592680
nsv834138 CNV Loss 17160897
nsv914400 CNV Loss 21882294
nsv3561 CNV Insertion 18451855
nsv509810 CNV Insertion 20534489

Relevant External Links for KLHL22 Gene

HapMap Linkage Disequilibrium report
KLHL22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL22 Gene

Disorders for KLHL22 Gene

Relevant External Links for KLHL22

Genetic Association Database (GAD)
KLHL22
Human Genome Epidemiology (HuGE) Navigator
KLHL22
genes like me logo Genes that share disorders with KLHL22: view

No data available for UniProtKB/Swiss-Prot for KLHL22 Gene

Publications for KLHL22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PMID: 19995937) Maerki S. … Peter M. (J. Cell Biol. 2009) 3 4
  5. Ubiquitylation-dependent localization of PLK1 in mitosis. (PMID: 23455478) Beck J. … Sumara I. (Nat. Cell Biol. 2013) 3 4

Products for KLHL22 Gene

Sources for KLHL22 Gene

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