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KLHL21 Gene

protein-coding   GIFtS: 53
GCID: GC01M006650

Kelch-Like Family Member 21

(Previous name: kelch-like 21 (Drosophila))
  Search for KLHL21
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 211 2
Kelch-Like 21 (Drosophila)1
Kelch-Like 212
Kelch-Like Protein 212
KIAA04693

External Ids:    HGNC: 290411   Entrez Gene: 99032   Ensembl: ENSG000001624137   UniProtKB: Q9UJP43   

Export aliases for KLHL21 gene to outside databases

Previous GC identifers: GC01M006586 GC01M005798


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL21 Gene:
KLHL21 (kelch-like family member 21) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is KLHL6.

UniProtKB/Swiss-Prot: KLH21_HUMAN, Q9UJP4
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates
localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and
mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not
lead to its degradation by the proteasome




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL21 gene promoter:
         Bach1   Lmo2   MIF-1   NF-E2 p45   FOXL1   CHOP-10   PPAR-gamma1   PPAR-gamma2   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL21 promoter sequence
   Search Chromatin IP Primers for KLHL21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.31   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36

KLHL21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL21 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006650:  view genomic region     (about GC identifiers)

Start:
6,650,784 bp from pter      End:
6,674,667 bp from pter
Size:
23,884 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLH21_HUMAN, Q9UJP4 (See protein sequence)
Recommended Name: Kelch-like protein 21  
Size: 597 amino acids; 66617 Da
Subunit: Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1
Sequence caution: Sequence=BAA32314.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KQP2 O75057 Q5SY26 Q5SY28 Q8N4I6 Q8NF10
Alternative splicing: 2 isoforms:  Q9UJP4-1   Q9UJP4-2   (Ref.1 (BAA32314) sequence is in conflict in position: 534:G->D)

Explore the universe of human proteins at neXtProt for KLHL21: NX_Q9UJP4

Explore proteomics data for KLHL21 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys33, Lys194, Lys370
  • Modification sites at PhosphoSitePlus

  • See KLHL21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055666.2  
    ENSEMBL proteins: 
     ENSP00000366886   ENSP00000366891   ENSP00000466089   ENSP00000468710   ENSP00000466479  
    Reactome Protein details: Q9UJP4

    KLHL21 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9UJP4

    ProtoNet protein and cluster: Q9UJP4

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH21_HUMAN, Q9UJP4
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH21_HUMAN, Q9UJP4
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
    efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates
    localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and
    mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not
    lead to its degradation by the proteasome

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA19995937
    GO:0005515protein binding ----
         
    KLHL21 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Klhl21):
     cardiovascular system  mortality/aging 

    KLHL21 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL21
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL21
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL21

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLHL21:
    hsa-mir-26b-5p (MIRT029862), hsa-mir-130b-3p (MIRT020304), hsa-mir-19b-3p (MIRT031234)

    Block miRNA regulation of human, mouse, rat KLHL21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL21 (see all 9):
    hsa-miR-3130-3p hsa-miR-3155 hsa-miR-548aa hsa-miR-3921 hsa-miR-484 hsa-miR-146a* hsa-miR-593 hsa-miR-4310
    SwitchGear 3'UTR luciferase reporter plasmidKLHL21 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat KLHL21

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL21

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLH21_HUMAN, Q9UJP4: Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to
    this region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005827polar microtubule IDA19995937
    GO:0031463Cul3-RING ubiquitin ligase complex IDA19995937

    KLHL21 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLHL21 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for KLHL21
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: KLH21_HUMAN, Q9UJP4
    Pathway: Protein modification; protein ubiquitination


    KLHL21 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including KLHL21: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for KLHL21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KLHL21 (Q9UJP43 ENSP000003668864) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKBQ96GD43, ENSP000003139504I2D: score=1 STRING: ENSP00000313950
    CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
    KLHL13Q9P2N73, ENSP000002628204I2D: score=1 STRING: ENSP00000262820
    KLHL9Q9P2J33, ENSP000003519334I2D: score=1 STRING: ENSP00000351933
    BIRC5ENSP000003016334STRING: ENSP00000301633
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination IDA19995937
    GO:0032465regulation of cytokinesis IMP19995937
    GO:0035853chromosome passenger complex localization to spindle midzone IMP19995937

    KLHL21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL21 (KLH21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLHL21 gene: 
    NM_014851.2  

    Unigene Cluster for KLHL21:

    Kelch-like family member 21
    Hs.7764  [show with all ESTs]
    Unigene Representative Sequence: NM_014851
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377658(uc009vme.3 uc001aoa.3) ENST00000377663(uc001anz.1)
    ENST00000467612 ENST00000496707 ENST00000463043
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLHL21 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL21 (see all 9):
    hsa-miR-3130-3p hsa-miR-3155 hsa-miR-548aa hsa-miR-3921 hsa-miR-484 hsa-miR-146a* hsa-miR-593 hsa-miR-4310
    SwitchGear 3'UTR luciferase reporter plasmidKLHL21 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat KLHL21

    Additional mRNA sequence: 

    AK057164.1 AK075305.1 AK090472.1 AK307564.1 BC034039.1 BC064980.1 BC091648.1 BC111766.1 

    12 DOTS entries:

    DT.100790856  DT.95279151  DT.414837  DT.100790853  DT.92442673  DT.100790852  DT.121348553  DT.121348589 
    DT.70100058  DT.87013624  DT.91833629  DT.95153309 

    1 AceView cDNA sequence:

    AL079660 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL21 expression in normal human tissues (normalized intensities)      KLHL21 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAGAATCC
    KLHL21 Expression
    About this image


    KLHL21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
    KLHL21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL21 Protein Expression

    Genevestigator expression for KLHL21

    SOURCE GeneReport for Unigene cluster: Hs.7764
        Pathway & Disease-focused RT2 Profiler PCR Array including KLHL21: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL21 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl211 , 5 kelch-like 21 (Drosophila)5
    kelch-like 211
    89.61(n)1
    96.65(a)1
      4 (82.82 cM)5
    2427851  NM_001033352.31  NP_001028524.11 
     1520088035 
    chicken
    (Gallus gallus)
    Aves KLHL211 kelch-like 21 (Drosophila) 79.52(n)
    82.04(a)
      428175  XM_003642517.2  XP_003642565.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.82692 Transcribed sequence with weak similarity to protein spQ9UJP4 (H.sapiens) Y469_HUMAN Hypothetical protein KIAA0469 less 76.28(n)    CF224081.1 
    zebrafish
    (Danio rerio)
    Actinopterygii klhl211 kelch-like 21 (Drosophila) 67.85(n)
    73.13(a)
      404613  NM_207081.1  NP_996964.1 


    ENSEMBL Gene Tree for KLHL21 (if available)
    TreeFam Gene Tree for KLHL21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL21 gene
    KLHL62  KBTBD82  KLHL412  KBTBD122  KBTBD22  KLHL242  ENC12  KLHL382  
    KLHL292  KBTBD32  KLHL232  KLHL402  KBTBD72  KLHL302  KBTBD62  KLHL252  
    KLHL352  
    Selected SIMAP similar genes for KLHL21 using alignment to 6 protein entries:     KLH21_HUMAN (see all proteins) (see all similar genes):
    KLHL17    IVNS1ABP    KLHL20    KBTBD3    KLHL24    KLHL29
    KLHL32    BACH2    KLHL30    KLHL3    KLHL2    KLHL6
    BTBD3    KLHDC8A    KLHL18    KLHL25    KLHL38    ENC1

    KLHL21 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL21 (see all 373)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1162899531,2
    F--6650316(+) TCATCG/CCAGAT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1915855681,2
    --6650363(+) AAGAAA/GGGCTG 1 -- int10--------
    rs1153039941,2
    F--6650377(+) GAGCCG/AGGCCC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1825100991,2
    --6650380(+) CCGGGC/TCCGGG 1 -- int10--------
    rs1851756001,2
    --6650431(+) GTTTCC/GTGGGC 1 -- int10--------
    rs1907694371,2
    --6650441(+) CATCAG/TCTGTT 1 -- int10--------
    rs1833260051,2
    --6650467(+) CTCAGA/GCCTCT 1 -- int10--------
    rs786556811,2
    C--6650476(+) CTCTC-/TTTAAAT 1 -- int10--------
    rs2002847171,2
    C--6650477(+) TCTCTC/TTAAAT 1 -- int10--------
    rs1422128351,2
    --6650603(+) CCTCTG/TGGGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for KLHL21 (6650784 - 6674667 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for KLHL21:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831536CNV Loss17160897
    dgv129n71CNV Loss21882294
    dgv130n71CNV Loss21882294
    nsv870646CNV Loss21882294
    nsv826253CNV Gain20364138
    nsv871348CNV Gain21882294
    nsv7880CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL21
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    KLHL21 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLHL21

    Export disorders for KLHL21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL21 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with KLHL21)
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    1. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PubMed id 19995937)1, 2 Maerki S.... Peter M. (J. Cell Biol. 2009)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
    5. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    6. Ubiquitylation-dependent localization of PLK1 in mitosis. (PubMed id 23455478)1 Beck J.... Sumara I. (Nat. Cell Biol. 2013)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9903 HGNC: 29041 AceView: KIAA0469.1 Ensembl:ENSG00000162413 euGenes: HUgn9903
    ECgene: KLHL21 H-InvDB: KLHL21

    (According to HUGE)
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    HUGE: KIAA0469

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLHL21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLHL21 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL21 gene:
    Search GeneIP for patents involving KLHL21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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