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Aliases for KLHL21 Gene

Aliases for KLHL21 Gene

  • Kelch Like Family Member 21 2 3 5
  • Kelch-Like 21 (Drosophila) 2
  • KIAA0469 4

External Ids for KLHL21 Gene

Previous GeneCards Identifiers for KLHL21 Gene

  • GC01M006586
  • GC01M005798
  • GC01M006650

Summaries for KLHL21 Gene

GeneCards Summary for KLHL21 Gene

KLHL21 (Kelch Like Family Member 21) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KLHL30.

UniProtKB/Swiss-Prot for KLHL21 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL21 Gene

Genomics for KLHL21 Gene

Regulatory Elements for KLHL21 Gene

Enhancers for KLHL21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F006598 1.1 FANTOM5 ENCODE 29.9 +12.4 12396 6.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 KLHL21 THAP3 RPL22 HES3 LOC102725193 ZBTB48 PHF13 PIR47122 PIR44711
GH01F006591 0.2 ENCODE 13 +23.0 22964 0.2 THAP3 KLHL21 PHF13 GC01M006590 PIR58337
GH01F006589 0.4 ENCODE 13 +25.2 25154 0.8 KLF1 ZFHX2 POLR2A SCRT2 ZBTB33 ZNF600 EGR2 THAP3 PHF13 KLHL21 TAS1R1 NOL9 ENSG00000229519 RNU6-731P DNAJC11 GC01M006590 ZBTB48
GH01F006587 0.4 ENCODE 12.5 +26.4 26383 1.5 POLR2A SCRT2 ZBTB33 TAS1R1 NOL9 PHF13 KLHL21 ENSG00000229519 RNU6-731P THAP3 DNAJC11 GC01M006590 ZBTB48
GH01F006649 0.3 FANTOM5 11 -34.5 -34489 0.1 THAP3 DNAJC11 KLHL21 PHF13 GC01M006638
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KLHL21 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001517014 507 4200 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3

Genomic Location for KLHL21 Gene

Chromosome:
1
Start:
6,590,724 bp from pter
End:
6,614,607 bp from pter
Size:
23,884 bases
Orientation:
Minus strand

Genomic View for KLHL21 Gene

Genes around KLHL21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL21 Gene

Proteins for KLHL21 Gene

  • Protein details for KLHL21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJP4-KLH21_HUMAN
    Recommended name:
    Kelch-like protein 21
    Protein Accession:
    Q9UJP4
    Secondary Accessions:
    • B3KQP2
    • O75057
    • Q5SY26
    • Q5SY28
    • Q8N4I6
    • Q8NF10

    Protein attributes for KLHL21 Gene

    Size:
    597 amino acids
    Molecular mass:
    66617 Da
    Quaternary structure:
    • Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.
    SequenceCaution:
    • Sequence=BAA32314.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL21 Gene

Post-translational modifications for KLHL21 Gene

  • Ubiquitination at Lys 33, Lys 194, and Lys 370
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL21 Gene

No data available for DME Specific Peptides for KLHL21 Gene

Domains & Families for KLHL21 Gene

Gene Families for KLHL21 Gene

Suggested Antigen Peptide Sequences for KLHL21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJP4

UniProtKB/Swiss-Prot:

KLH21_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL21: view

Function for KLHL21 Gene

Molecular function for KLHL21 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

Gene Ontology (GO) - Molecular Function for KLHL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19995937
genes like me logo Genes that share ontologies with KLHL21: view
genes like me logo Genes that share phenotypes with KLHL21: view

Animal Models for KLHL21 Gene

MGI Knock Outs for KLHL21:

Animal Model Products

miRNA for KLHL21 Gene

miRTarBase miRNAs that target KLHL21

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHL21 Gene

Localization for KLHL21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL21 Gene

Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to this region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL21 Gene COMPARTMENTS Subcellular localization image for KLHL21 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005819 spindle IEA --
GO:0005827 polar microtubule IDA 19995937
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with KLHL21: view

Pathways & Interactions for KLHL21 Gene

genes like me logo Genes that share pathways with KLHL21: view

UniProtKB/Swiss-Prot Q9UJP4-KLH21_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KLHL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0016567 protein ubiquitination IEA,IDA 19995937
GO:0032465 regulation of cytokinesis IMP 19995937
GO:0035853 chromosome passenger complex localization to spindle midzone IMP 19995937
genes like me logo Genes that share ontologies with KLHL21: view

No data available for SIGNOR curated interactions for KLHL21 Gene

Transcripts for KLHL21 Gene

mRNA/cDNA for KLHL21 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL21 Gene

Kelch-like family member 21:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL21 Gene

No ASD Table

Relevant External Links for KLHL21 Gene

GeneLoc Exon Structure for
KLHL21
ECgene alternative splicing isoforms for
KLHL21

Expression for KLHL21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLHL21 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL21 Gene

This gene is overexpressed in Muscle - Skeletal (x5.5).

Protein differential expression in normal tissues from HIPED for KLHL21 Gene

This gene is overexpressed in Bone (30.7) and Platelet (25.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHL21 Gene



NURSA nuclear receptor signaling pathways regulating expression of KLHL21 Gene:

KLHL21

SOURCE GeneReport for Unigene cluster for KLHL21 Gene:

Hs.7764
genes like me logo Genes that share expression patterns with KLHL21: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KLHL21 Gene

Orthologs for KLHL21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL21 34 35
  • 98.81 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL21 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL21 34 35
  • 92.52 (n)
cow
(Bos Taurus)
Mammalia KLHL21 34 35
  • 91.96 (n)
rat
(Rattus norvegicus)
Mammalia Klhl21 34
  • 90.03 (n)
mouse
(Mus musculus)
Mammalia Klhl21 34 16 35
  • 89.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL21 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL21 34 35
  • 79.52 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl21 34
  • 68.98 (n)
Str.8269 34
zebrafish
(Danio rerio)
Actinopterygii klhl21 34 35
  • 67.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
OneToOne
Species where no ortholog for KLHL21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL21 Gene

ENSEMBL:
Gene Tree for KLHL21 (if available)
TreeFam:
Gene Tree for KLHL21 (if available)

Paralogs for KLHL21 Gene

Paralogs for KLHL21 Gene

genes like me logo Genes that share paralogs with KLHL21: view

Variants for KLHL21 Gene

Sequence variations from dbSNP and Humsavar for KLHL21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1043868 -- 6,590,843(-) CCCCA(A/G)AGGGT utr-variant-3-prime
rs11122102 -- 6,598,710(+) ACCCC(A/G)TCTCT intron-variant
rs111401024 -- 6,604,761(+) CTCAC(A/G)CCTGT intron-variant, upstream-variant-2KB
rs111407998 -- 6,591,289(+) GGCAC(A/C)ATCCC utr-variant-3-prime
rs111512176 -- 6,599,394(+) CACTC(A/G)TTCAC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for KLHL21 Gene

Variant ID Type Subtype PubMed ID
nsv545269 CNV loss 21841781
nsv7880 CNV gain+loss 18304495
nsv826253 CNV gain 20364138
nsv831536 CNV loss 17160897
nsv955151 CNV deletion 24416366

Variation tolerance for KLHL21 Gene

Gene Damage Index Score: 2.84; 47.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL21 Gene

Disorders for KLHL21 Gene

Relevant External Links for KLHL21

Genetic Association Database (GAD)
KLHL21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL21

No disorders were found for KLHL21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL21 Gene

Publications for KLHL21 Gene

  1. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PMID: 19995937) Maerki S. … Peter M. (J. Cell Biol. 2009) 3 4 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for KLHL21 Gene

Sources for KLHL21 Gene

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