Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLHL21 Gene

Aliases for KLHL21 Gene

  • Kelch-Like Family Member 21 2 3
  • Kelch-Like 21 (Drosophila) 2
  • KIAA0469 4

External Ids for KLHL21 Gene

Previous GeneCards Identifiers for KLHL21 Gene

  • GC01M006586
  • GC01M005798
  • GC01M006650

Summaries for KLHL21 Gene

GeneCards Summary for KLHL21 Gene

KLHL21 (Kelch-Like Family Member 21) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KBTBD6.

UniProtKB/Swiss-Prot for KLHL21 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL21 Gene

Genomics for KLHL21 Gene

Regulatory Elements for KLHL21 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL21 Gene

Start:
6,590,724 bp from pter
End:
6,614,607 bp from pter
Size:
23,884 bases
Orientation:
Minus strand

Genomic View for KLHL21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL21 Gene

Proteins for KLHL21 Gene

  • Protein details for KLHL21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJP4-KLH21_HUMAN
    Recommended name:
    Kelch-like protein 21
    Protein Accession:
    Q9UJP4
    Secondary Accessions:
    • B3KQP2
    • O75057
    • Q5SY26
    • Q5SY28
    • Q8N4I6
    • Q8NF10

    Protein attributes for KLHL21 Gene

    Size:
    597 amino acids
    Molecular mass:
    66617 Da
    Quaternary structure:
    • Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1.
    SequenceCaution:
    • Sequence=BAA32314.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL21 Gene

Proteomics data for KLHL21 Gene at MOPED

Post-translational modifications for KLHL21 Gene

  • Ubiquitination at Lys33, Lys194, and Lys370
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL21 Gene

No data available for DME Specific Peptides for KLHL21 Gene

Domains for KLHL21 Gene

Gene Families for KLHL21 Gene

HGNC:
  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJP4

UniProtKB/Swiss-Prot:

KLH21_HUMAN :
  • Q9UJP4
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL21: view

Function for KLHL21 Gene

Molecular function for KLHL21 Gene

UniProtKB/Swiss-Prot Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

Gene Ontology (GO) - Molecular Function for KLHL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19995937
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL21: view

Phenotypes for KLHL21 Gene

genes like me logo Genes that share phenotypes with KLHL21: view

Animal Model Products

CRISPR Products

miRNA for KLHL21 Gene

miRTarBase miRNAs that target KLHL21

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL21 Gene

Localization for KLHL21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL21 Gene

Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to this region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL21 Gene COMPARTMENTS Subcellular localization image for KLHL21 gene
Compartment Confidence
cytoskeleton 5
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
GO:0005827 polar microtubule IDA 19995937
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 19995937
genes like me logo Genes that share ontologies with KLHL21: view

Pathways for KLHL21 Gene

genes like me logo Genes that share pathways with KLHL21: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9UJP4-KLH21_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for KLHL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0016567 protein ubiquitination IEA --
GO:0032465 regulation of cytokinesis IMP 19995937
GO:0035853 chromosome passenger complex localization to spindle midzone IMP 19995937
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with KLHL21: view

Transcripts for KLHL21 Gene

mRNA/cDNA for KLHL21 Gene

(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL21 Gene

Kelch-like family member 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL21

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL21 Gene

No ASD Table

Relevant External Links for KLHL21 Gene

GeneLoc Exon Structure for
KLHL21
ECgene alternative splicing isoforms for
KLHL21

Expression for KLHL21 Gene

mRNA expression in normal human tissues for KLHL21 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL21 Gene

This gene is overexpressed in Muscle - Skeletal (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL21 Gene

SOURCE GeneReport for Unigene cluster for KLHL21 Gene Hs.7764

genes like me logo Genes that share expressions with KLHL21: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KLHL21 Gene

Orthologs for KLHL21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL21 35
  • 98.81 (n)
  • 99.55 (a)
KLHL21 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHL21 35
  • 91.96 (n)
  • 96.98 (a)
KLHL21 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL21 35
  • 92.52 (n)
  • 97.15 (a)
KLHL21 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl21 35
  • 89.61 (n)
  • 96.65 (a)
Klhl21 16
Klhl21 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHL21 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL21 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl21 35
  • 90.03 (n)
  • 97.42 (a)
chicken
(Gallus gallus)
Aves KLHL21 35
  • 79.52 (n)
  • 82.04 (a)
KLHL21 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl21 35
  • 68.98 (n)
  • 74.31 (a)
Str.8269 35
zebrafish
(Danio rerio)
Actinopterygii klhl21 35
  • 67.85 (n)
  • 73.13 (a)
klhl21 36
  • 67 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for KLHL21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL21 Gene

ENSEMBL:
Gene Tree for KLHL21 (if available)
TreeFam:
Gene Tree for KLHL21 (if available)

Paralogs for KLHL21 Gene

genes like me logo Genes that share paralogs with KLHL21: view

Variants for KLHL21 Gene

Sequence variations from dbSNP and Humsavar for KLHL21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs183901 -- 6,598,845(+) gccac(A/T)gcact intron-variant
rs201158 -- 6,598,851(+) gcact(C/G)cagcc intron-variant
rs201159 -- 6,598,831(+) tgagc(C/G/T)gagat intron-variant
rs201171 -- 6,591,033(-) AGATG(C/T)TGGGA utr-variant-3-prime
rs1043868 -- 6,590,843(-) CCCCA(A/G)AGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL21 Gene

Variant ID Type Subtype PubMed ID
nsv7880 CNV Gain+Loss 18304495
nsv831536 CNV Loss 17160897
dgv129n71 CNV Loss 21882294
nsv871348 CNV Gain 21882294
nsv870646 CNV Loss 21882294
dgv130n71 CNV Loss 21882294
nsv826253 CNV Gain 20364138

Relevant External Links for KLHL21 Gene

HapMap Linkage Disequilibrium report
KLHL21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL21 Gene

Disorders for KLHL21 Gene

Relevant External Links for KLHL21

Genetic Association Database (GAD)
KLHL21
genes like me logo Genes that share disorders with KLHL21: view

No data available for UniProtKB/Swiss-Prot for KLHL21 Gene

Publications for KLHL21 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PMID: 19995937) Maerki S. … Peter M. (J. Cell Biol. 2009) 3 4
  4. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KLHL21 Gene

  • antibodies-online proteins for KLHL21
  • antibodies-online antibodies for KLHL21
  • antibodies-online kits for KLHL21

Sources for KLHL21 Gene

Back to Top

Content