Aliases for KLHL2 Gene
External Ids for KLHL2 Gene
Previous GeneCards Identifiers for KLHL2 Gene
GeneCards Summary for KLHL2 Gene
KLHL2 (Kelch Like Family Member 2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include actin binding. An important paralog of this gene is KLHL3.
UniProtKB/Swiss-Prot for KLHL2 Gene
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.