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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL2 Gene

protein-coding   GIFtS: 56
GCID: GC04P166128

Kelch-Like Family Member 2

(Previous names: kelch (Drosophila)-like 2 (Mayven), kelch-like 2, Mayven...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 21 2     ABP-KELCH2
Actin-Binding Protein Mayven2 3     MAV2
MAYVEN2 5     kelch2
Kelch (Drosophila)-Like 2 (Mayven)1     Kelch-Like 2, Mayven2
Kelch-Like 2, Mayven (Drosophila)1     Kelch-Like Protein 22
mayven1     

External Ids:    HGNC: 63531   Entrez Gene: 112752   Ensembl: ENSG000001094667   OMIM: 6057745   UniProtKB: O951983   

Export aliases for KLHL2 gene to outside databases

Previous GC identifers: GC04P166992 GC04P166557 GC04P166706 GC04P166486 GC04P166348 GC04P161880


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLHL2 Gene: 
KLHL2 (kelch-like family member 2) is a protein-coding gene. Diseases associated with KLHL2 include contagious pustular dermatitis, and monkeypox. GO annotations related to this gene include actin binding and transporter activity. An important paralog of this gene is KLHL17.

UniProtKB/Swiss-Prot: KLHL2_HUMAN, O95198
Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates
the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By
similarity). Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in
oligodendrocyte precursors




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL2 gene promoter:
         Nkx3-1   Nkx3-1 v4   AP-1   ATF-2   Nkx3-1 v1   Nkx3-1 v2   STAT3   Nkx3-1 v3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.2   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q21.2

KLHL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P166128:  view genomic region     (about GC identifiers)

Start:
166,128,770 bp from pter      End:
166,244,308 bp from pter
Size:
115,539 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLHL2_HUMAN, O95198 (See protein sequence)
Recommended Name: Kelch-like protein 2  
Size: 593 amino acids; 65975 Da
Subunit: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Interacts with
NPTXR and CUL3 (By similarity). Binds actin. Interacts with KLHL12. Interacts (via N-terminus) with FYN (via SH3
domain)
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection (By similarity). Cell
projection, lamellipodium (By similarity). Cytoplasm, cytosol. Note=A proportion colocalizes with the actin
cytoskeleton. When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity)
1 PDB 3D structure from and Proteopedia for KLHL2:
2XN4 (3D)    
Secondary accessions: A6NCM7 B4DFH7 F5H6M3 Q8N484 Q8TBH5
Alternative splicing: 3 isoforms:  O95198-1   O95198-2   O95198-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for KLHL2: NX_O95198

Explore proteomics data for KLHL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95198

  • KLHL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001154993.1  NP_001154994.1  NP_009177.3  

    ENSEMBL proteins: 
     ENSP00000226725   ENSP00000422113   ENSP00000421324   ENSP00000424198   ENSP00000421844  
     ENSP00000408974   ENSP00000424108   ENSP00000437526  

    Human Recombinant Protein Products for KLHL2: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for KLHL2 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol IEA--
    GO:0015629actin cytoskeleton IDA10397770
    GO:0030027lamellipodium IEA--

    KLHL2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    5/7 InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O95198

    ProtoNet protein and cluster: O95198

    2 Blocks protein domains:
    IPB011498 Kelch
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLHL2_HUMAN, O95198
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLHL2_HUMAN, O95198
    Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates
    the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By
    similarity). Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in
    oligodendrocyte precursors

         Genatlas biochemistry entry for KLHL2:
    Kelch (Drosophila)-like 2,actin-binding protein,termed Mayven,predominantly expressed in brain,that may be
    translocated along axonal processes and might be involved in the dynamic organization of the actin cytoskeleton
    in brain cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA10397770
    GO:0005515protein binding IPI--
         
    KLHL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL2:
     Increased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL2 
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    hsa-miR-193a-3p hsa-miR-892b hsa-miR-181c hsa-miR-3664-5p hsa-miR-1271 hsa-miR-1278 hsa-miR-340 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL2 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLHL2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for KLHL2 (O951982, 3 ENSP000002267254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLHL12Q53G592, 3, ENSP000003562304MINT-66974 I2D: score=6 STRING: ENSP00000356230
    CUL3Q136183I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination ISS--

    KLHL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL2

    Search CenterWatch for drugs/clinical trials and news about KLHL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL2 gene (3 alternative transcripts): 
    NM_001161521.1  NM_001161522.1  NM_007246.3  

    Unigene Cluster for KLHL2:

    Kelch-like family member 2
    Hs.388668  [show with all ESTs]
    Unigene Representative Sequence: BC022503
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226725(uc003irb.3) ENST00000511305 ENST00000509704 ENST00000514860
    ENST00000506824 ENST00000421009 ENST00000506541 ENST00000506761 ENST00000509028
    ENST00000538127(uc011cjm.2 uc003irc.3 uc010ira.3)
    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL2 (see all 24):
    hsa-miR-193a-3p hsa-miR-892b hsa-miR-181c hsa-miR-3664-5p hsa-miR-1271 hsa-miR-1278 hsa-miR-340 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209727.1 AF059569.1 AK025289.1 AK294103.1 AK294336.1 AK308940.1 AK315372.1 BC022503.1 
    BC036468.2 BX647776.1 

    9 DOTS entries:

    DT.308481  DT.92425498  DT.121225319  DT.92425499  DT.121225310  DT.121225325  DT.433589  DT.92425500 
    DT.92425501 

    24/68 AceView cDNA sequences (see all 68):

    BM996343 BG117651 BC036468 AW104903 AK025289 BM718818 AI583009 BU608540 
    CB241258 D81411 BM675125 BM680706 BQ017177 CA393754 BM972676 AA330533 
    BI457602 BX452163 BQ421470 AI814691 BM744516 AA812982 BC022503 CB143650 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:        -     -                       -                                                                           
    SP2:                          -           -                                                                           
    SP3:                                                                                                                  
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for KLHL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL2 expression in normal human tissues (normalized intensities)      KLHL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTCTTGA
    KLHL2 Expression
    About this image


    KLHL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells ( Generation of mesendoderm and definitive endoderm...

    See KLHL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL2

    SOURCE GeneReport for Unigene cluster: Hs.388668

    UniProtKB/Swiss-Prot: KLHL2_HUMAN, O95198
    Tissue specificity: Ubiquitous. Detected throughout the brain

        SABiosciences Expression via Pathway-Focused PCR Array including KLHL2: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLHL2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl21 , 5 kelch-like 2, Mayven (Drosophila)1, 5 88.76(n)1
    98.82(a)1
      8 (32.30 cM)5
    771131  NM_178633.21  NP_848748.21 
     647398635 
    chicken
    (Gallus gallus)
    Aves KLHL21 kelch-like 2, Mayven (Drosophila) 83.73(n)
    92.52(a)
      422422  XM_420390.3  XP_420390.2 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL26
    kelch-like family member 2
    88(a)
    1 ↔ 1
    GL343317.1(25973-74531)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-287c11.11 si:ch211-287c11.1 72.58(n)
    81.74(a)
      567966  XM_691277.5  XP_696369.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta kel3 oogenesis actin binding 61(a)
    (best of 4)
      36D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea kel-13 ring canal protein like 41(a)
    (best of 3)
      II(11688872-11695905)   --


    ENSEMBL Gene Tree for KLHL2 (if available)
    TreeFam Gene Tree for KLHL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL2 gene
    KLHL172  KLHL182  KLHL202  KLHL52  KLHL122  KEAP12  KLHL282  KLHL42  
    KLHL32  IPP2  KLHL82  KLHL102  KLHL12  
    18/82 SIMAP similar genes for KLHL2 using alignment to 7 protein entries:     KLHL2_HUMAN (see all proteins) (see all similar genes):
    KLHL3    ZNF738    AURA2    SHANK2    EIF3L    TMEM14B
    FAM129C    ZBTB7C    NF2    GLT8D2    NEK4    ZBTB4
    ZNF564    MED15    FAM175A    FAM3A    SEPT2    BACH1

    KLHL2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for KLHL2
    PGOHUM00000259954 PGOHUM00000259955


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2095 SNPs in KLHL2 are shown (see all 2095)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927669611,2
    C--166126841(+) ATCTCA/GGCTCA 1 -- us2k10--------
    rs1479912481,2
    --166126875(+) CGAGTC/GATTCT 1 -- us2k10--------
    rs1145043341,2
    F--166126932(+) ACACCC/TGGCTA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1406880691,2
    C--166127033(+) GTGCTA/GGGATT 1 -- us2k10--------
    rs1824875051,2
    --166127055(+) CCACCG/TCGCCC 1 -- us2k10--------
    rs1151602931,2
    F--166127208(+) AGACGG/TAGTTT 1 -- us2k11Minor allele frequency- T:0.05NA 120
    rs1868108161,2
    --166127285(+) CCTAGA/TTCAAG 1 -- us2k10--------
    rs68428751,2
    C--166127333(+) acaggC/Tatgca 1 -- us2k10--------
    rs100113841,2
    C--166127470(+) caggcA/Gtgagc 1 -- us2k10--------
    rs1133179891,2
    C,F--166127557(+) CAGATG/CAAGCT 1 -- us2k11Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for KLHL2 (166128770 - 166244308 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLHL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv26333CNV Loss19812545
    esv21788CNV Loss19812545
    nsv881168CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605774    OMIM disorders: --

    9 diseases for KLHL2:    About MalaCards
    contagious pustular dermatitis    monkeypox    smallpox    cowpox
    vaccinia    skin disease    dermatitis    breast cancer
    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for KLHL2:
    Cowpox     Monkeypox     Smallpox

    KLHL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLHL2
    Human Genome Epidemiology (HuGE) Navigator: KLHL2 (1 document)

    Export disorders for KLHL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with KLHL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. (PubMed id 10397770)1, 2, 3, 9 Soltysik-Espanola M.B.... Avraham S. (1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Role of Mayven, a kelch-related protein in oligodendrocyte process formation. (PubMed id 16035103)1, 3 Williams S.K....Barnett S.C. (2005)
    4. hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure. (PubMed id 15383316)1, 2 Mai A....Yonehara S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells. (PubMed id 15735724)1, 9 Bu X....Avraham S. (2005)
    7. Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PubMed id 23349464)2 Canning P.... Bullock A.N. (2013)
    8. KLHL2 interacts with and ubiquitinates WNK kinases. (PubMed id 23838290)1 Takahashi D....Uchida S. (2013)
    9. Interaction of an intracellular pentraxin with a BTB- Kelch protein is associated with ubiquitylation, aggregation and neuronal apopt osis. (PubMed id 21549840)1 Tseng L.A. and Bixby J.L. (2011)
    10. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11275 HGNC: 6353 AceView: KLHL2 Ensembl:ENSG00000109466 euGenes: HUgn11275
    ECgene: KLHL2 H-InvDB: KLHL2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL2 gene:
    Search GeneIP for patents involving KLHL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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