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KLHL18 Gene

protein-coding   GIFtS: 49
GCID: GC03P047325

Kelch-Like Family Member 18

(Previous name: kelch-like 18 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 181 2
Kelch-Like 18 (Drosophila)1
Kelch-Like Protein 182
KIAA07953

External Ids:    HGNC: 291201   Entrez Gene: 232762   Ensembl: ENSG000001146487   UniProtKB: O948893   

Export aliases for KLHL18 gene to outside databases

Previous GC identifer: GC03P047299


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL18 Gene:
KLHL18 (kelch-like family member 18) is a protein-coding gene. An important paralog of this gene is KLHL17.

Gene Wiki entry for KLHL18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL18 gene promoter:
         AML1a   GCNF   AP-4   Ik-3   c-Ets-1   PPAR-alpha   AREB6   FOXO4   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL18 promoter sequence
   Search Chromatin IP Primers for KLHL18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

KLHL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL18 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P047325:  view genomic region     (about GC identifiers)

Start:
47,324,330 bp from pter      End:
47,388,306 bp from pter
Size:
63,977 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLH18_HUMAN, O94889 (See protein sequence)
Recommended Name: Kelch-like protein 18  
Size: 574 amino acids; 63638 Da
Sequence caution: Sequence=AAH32620.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD97920.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K612 Q7Z3E8 Q8N125
Alternative splicing: 2 isoforms:  O94889-1   O94889-2   

Explore the universe of human proteins at neXtProt for KLHL18: NX_O94889

Explore proteomics data for KLHL18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLHL18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079286.2  
    ENSEMBL proteins: 
     ENSP00000407114   ENSP00000411839   ENSP00000232766   ENSP00000392507   ENSP00000405585  

    KLHL18 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLHL18

     
    Search eBioscience for Proteins for KLHL18 

     
    antibodies-online proteins for KLHL18 (2 products) 

     
    Search antibodies-online for peptides for KLHL18

    KLHL18 Antibody Products:

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    Abcam antibodies for KLHL18
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    ThermoFisher Antibody for KLHL18
    antibodies-online antibodies for KLHL18 (4 products) 

    KLHL18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for KLHL18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLHL18
    Cloud-Clone Corp. CLIAs for KLHL18
    Search eBioscience for ELISAs for KLHL18 
    antibodies-online kits for KLHL18 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O94889

    ProtoNet protein and cluster: O94889

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KLH18_HUMAN, O94889
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Find genes that share domains with KLHL18           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KLHL18           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL18:
     Decreased Wnt reporter activit 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Klhl18):
     hearing/vestibular/ear 

    Find genes that share phenotypes with KLHL18           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KLHL18

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLHL18:
    hsa-mir-103a-3p (MIRT027008)

    Block miRNA regulation of human, mouse, rat KLHL18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL18 (see all 83):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-3916 hsa-miR-1243 hsa-miR-3909 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidKLHL18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLHL18
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL18

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for KLHL18 (see all 7)
    OriGene ORF clones in mouse, rat for KLHL18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL18 (NM_025010)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL18

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL18 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL18
    Interactions:

        Search GeneGlobe Interaction Network for KLHL18

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for KLHL18 (O948893 ENSP000002327664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    COPS6Q7L5N13, ENSP000003041024I2D: score=1 STRING: ENSP00000304102
    EEF1GP266413I2D: score=2 
    RBL1P287493I2D: score=1 
    TRIM37O949723I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL18 (KLH18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLHL18 gene: 
    NM_025010.4  

    Unigene Cluster for KLHL18:

    Kelch-like family member 18
    Hs.517946  [show with all ESTs]
    Unigene Representative Sequence: AB062478
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433449 ENST00000437353 ENST00000461084(uc003crc.2 uc010hjq.2)
    ENST00000232766(uc003crd.3 uc011bav.2) ENST00000442272 ENST00000483201(uc003crb.2)
    ENST00000455924
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLHL18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL18 (see all 83):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-3916 hsa-miR-1243 hsa-miR-3909 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidKLHL18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLHL18
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL18
    Clone
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    OriGene clones in human, mouse for KLHL18 (see all 7)
    OriGene ORF clones in mouse, rat for KLHL18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL18 (NM_025010)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL18
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL18
      QuantiTect SYBR Green Assays in human, mouse, rat KLHL18
      QuantiFast Probe-based Assays in human, mouse, rat KLHL18

    Additional mRNA sequence: 

    AB018338.1 AB062478.1 AK001337.1 AK023765.1 AK291477.1 AK295292.1 AY714879.1 BC015962.1 
    BC016388.2 BC032620.1 BX537953.1 

    9 DOTS entries:

    DT.215035  DT.100775202  DT.100775198  DT.75131759  DT.102831744  DT.97841631  DT.100651272  DT.91858701 
    DT.97815828 

    Selected AceView cDNA sequences (see all 144):

    BM452344 BU625052 AB018338 T34063 AB062478 BM142120 BU172490 AA301842 
    AI754328 Z38488 AW151264 AI867863 AI147462 BF111989 BQ436073 CA398203 
    BM673613 AW083400 AI630602 AI356423 AA489670 BM976127 CA309636 CA398204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLHL18 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14
    SP1:              -     -     -     -                                                                 -                 -                     
    SP2:                                                                                                  -                 -                     
    SP3:              -     -     -     -                                                                 -                                       
    SP4:                                                                                                                                          
    SP5:              -           -     -                                                                                                         


    ECgene alternative splicing isoforms for KLHL18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTTGTGT
    KLHL18 Expression
    About this image

    KLHL18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517946
        Custom PCR Arrays for KLHL18
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL18
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KLHL18 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl181 , 5 kelch-like 18 (Drosophila)5
    kelch-like 181
    91.11(n)1
    98.43(a)1
      9 (59.92 cM)5
    2702011  NM_177771.51  NP_808439.21 
     1104259285 
    chicken
    (Gallus gallus)
    Aves KLHL181 kelch-like 18 (Drosophila) 83.54(n)
    92.39(a)
      420406  NM_001030960.2  NP_001026131.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL186
    kelch-like family member 18
    89(a)
    1 ↔ 1
    GL343865.1(112865-143431)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klhl181 kelch-like family member 18 79.63(n)
    88.79(a)
      100170176  NM_001129932.1  NP_001123404.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi18c082 wufi18c08 76.83(n)   327574  BC045319.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta KLHL181 KLHL18 58.23(n)
    54.97(a)
      41458  NM_001275565.1  NP_001262494.1 
    worm
    (Caenorhabditis elegans)
    Secernentea kel-31 kel-3 50(n)
    45.45(a)
      176775  NM_067383.4  NP_499784.2 


    ENSEMBL Gene Tree for KLHL18 (if available)
    TreeFam Gene Tree for KLHL18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL18 gene
    KLHL172  KLHL202  KLHL52  KLHL122  KEAP12  KLHL282  KLHL42  KLHL32  
    KLHL82  KLHL102  KLHL12  KLHL22  
    Selected SIMAP similar genes for KLHL18 using alignment to 8 protein entries:     KLH18_HUMAN (see all proteins) (see all similar genes):
    ZBTB4    ZBTB44    KLHL20    KLHL17    KLHL3    KBTBD8
    KLHL12    KLHL8    KLHL1    ZBTB16    KEAP1    KLHL5
    DKFZp686P15123    KLHL4    KLHL2    KLHL28    ZBTB45    DKFZp686H07112

    Find genes that share paralogs with KLHL18           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL18 (see all 1085)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs556958491,2
    C--47341345(+) AAAAA-/A/AA  
            
    GATTG
    1 -- int11NA 2
    rs668672181,2
    C--47357256(-) TTTCC-/TGAGA 
            
    TATTT
    1 -- int12Minor allele frequency- TGAGA:0.25NA 4
    rs716154601,2
    C--47358217(+) TGTGTA/GTATAT 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1132952841,2
    C,F--47365401(+) CACCCG/ATCTTG 1 -- us2k12Minor allele frequency- A:0.01CSA EU 570
    rs1147175131,2
    F--47365504(+) ACGTCG/ACTTCA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1900093491,2
    --47365515(+) TTTGAA/GTGGGT 1 -- us2k10--------
    rs8079361,2
    C,F,O,A,H--47365528(+) CAGTTC/TCCAAA 1 -- us2k127Minor allele frequency- T:0.47NA NS EA WA CSA 2496
    rs1448860361,2
    --47365535(+) CAAAAC/TTAAAT 1 -- us2k10--------
    rs1928388201,2
    --47365569(+) TTGTGC/TTTTTT 1 -- us2k10--------
    rs1848526451,2
    --47365621(+) GCACAA/GAGTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLHL18 (47324330 - 47388306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLHL18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2417653CNV Deletion18987734
    nsv428417CNV Loss18775914
    nsv876756CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL18
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL18 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with KLHL18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    6. An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)1 Olma M.H....Pintard L. (J. Cell. Sci. 2009)
    7. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23276 HGNC: 29120 AceView: KLHL18 Ensembl:ENSG00000114648 euGenes: HUgn23276
    ECgene: KLHL18 H-InvDB: KLHL18

    (According to HUGE)
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    HUGE: KIAA0795

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLHL18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL18 gene:
    Search GeneIP for patents involving KLHL18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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