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Aliases for KLHL18 Gene

Aliases for KLHL18 Gene

  • Kelch Like Family Member 18 2 3 5
  • Kelch-Like 18 (Drosophila) 2
  • KIAA0795 4

External Ids for KLHL18 Gene

Previous GeneCards Identifiers for KLHL18 Gene

  • GC03P047299
  • GC03P047325

Summaries for KLHL18 Gene

GeneCards Summary for KLHL18 Gene

KLHL18 (Kelch Like Family Member 18) is a Protein Coding gene. An important paralog of this gene is KLHL5.

Gene Wiki entry for KLHL18 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL18 Gene

Genomics for KLHL18 Gene

Regulatory Elements for KLHL18 Gene

Enhancers for KLHL18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL18 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL18 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL18 Gene

47,282,840 bp from pter
47,346,816 bp from pter
63,977 bases
Plus strand

Genomic View for KLHL18 Gene

Genes around KLHL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL18 Gene

Proteins for KLHL18 Gene

  • Protein details for KLHL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 18
    Protein Accession:
    Secondary Accessions:
    • A8K612
    • Q7Z3E8
    • Q8N125

    Protein attributes for KLHL18 Gene

    574 amino acids
    Molecular mass:
    63638 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH32620.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD97920.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL18 Gene


neXtProt entry for KLHL18 Gene

Proteomics data for KLHL18 Gene at MOPED

Post-translational modifications for KLHL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL18 Gene

No data available for DME Specific Peptides for KLHL18 Gene

Domains & Families for KLHL18 Gene

Gene Families for KLHL18 Gene

Protein Domains for KLHL18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL18: view

Function for KLHL18 Gene

Gene Ontology (GO) - Molecular Function for KLHL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL18: view
genes like me logo Genes that share phenotypes with KLHL18: view

Animal Models for KLHL18 Gene

MGI Knock Outs for KLHL18:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLHL18 Gene

Localization for KLHL18 Gene

Subcellular locations from

Jensen Localization Image for KLHL18 Gene COMPARTMENTS Subcellular localization image for KLHL18 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL18 Gene

Pathways & Interactions for KLHL18 Gene

SuperPathways for KLHL18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHL18 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHL18 Gene

Drugs & Compounds for KLHL18 Gene

No Compound Related Data Available

Transcripts for KLHL18 Gene

Unigene Clusters for KLHL18 Gene

Kelch-like family member 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL18 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14
SP1: - - - - - -
SP2: - -
SP3: - - - - -
SP5: - - -
SP6: - - - - - -
SP7: -
SP8: -

Relevant External Links for KLHL18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL18 Gene

mRNA expression in normal human tissues for KLHL18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL18 Gene

This gene is overexpressed in Retina (39.9) and Testis (29.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL18 Gene

SOURCE GeneReport for Unigene cluster for KLHL18 Gene Hs.517946

genes like me logo Genes that share expression patterns with KLHL18: view

Protein tissue co-expression partners for KLHL18 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL18 Gene

Orthologs for KLHL18 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100847139 35
  • 91.7 (n)
  • 96.69 (a)
KLHL18 36
  • 96 (a)
(Canis familiaris)
Mammalia KLHL18 35
  • 91.41 (n)
  • 96.86 (a)
KLHL18 36
  • 95 (a)
(Mus musculus)
Mammalia Klhl18 35
  • 91.11 (n)
  • 98.43 (a)
Klhl18 16
Klhl18 36
  • 98 (a)
(Pan troglodytes)
Mammalia KLHL18 35
  • 99.54 (n)
  • 99.65 (a)
KLHL18 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhl18 35
  • 90.77 (n)
  • 97.91 (a)
(Monodelphis domestica)
Mammalia KLHL18 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
(Gallus gallus)
Aves KLHL18 35
  • 83.54 (n)
  • 92.39 (a)
KLHL18 36
  • 91 (a)
(Anolis carolinensis)
Reptilia KLHL18 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl18 35
  • 79.63 (n)
  • 88.79 (a)
(Danio rerio)
Actinopterygii klhl18 35
  • 74.63 (n)
  • 83.19 (a)
wufi18c08 35
klhl18 36
  • 82 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011142 35
  • 57.95 (n)
  • 55.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta KLHL18 35
  • 58.23 (n)
  • 54.97 (a)
KLHL18 36
  • 53 (a)
(Caenorhabditis elegans)
Secernentea kel-3 35
  • 50 (n)
  • 45.45 (a)
kel-3 36
  • 43 (a)
Species with no ortholog for KLHL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHL18 Gene

Gene Tree for KLHL18 (if available)
Gene Tree for KLHL18 (if available)

Paralogs for KLHL18 Gene

genes like me logo Genes that share paralogs with KLHL18: view

Variants for KLHL18 Gene

Sequence variations from dbSNP and Humsavar for KLHL18 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs704925 -- 47,336,611(+) ACAGC(A/C)CGCAG reference, synonymous-codon
rs2302278 -- 47,319,592(+) TTTTT(G/T)TTTGT intron-variant
rs295428 -- 47,317,772(+) taggg(G/T)atagt intron-variant
rs295429 -- 47,319,610(+) TGTTT(C/T)GCATT intron-variant
rs295430 -- 47,319,618(+) ATTCC(A/T)CAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL18 Gene

Variant ID Type Subtype PubMed ID
nsv428417 CNV Loss 18775914
nsv876756 CNV Gain 21882294
esv2417653 CNV Deletion 18987734

Variation tolerance for KLHL18 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLHL18 Gene

Disorders for KLHL18 Gene

Relevant External Links for KLHL18

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL18 Gene

Publications for KLHL18 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3

Products for KLHL18 Gene

Sources for KLHL18 Gene