KLHL18 Gene
protein-coding GIFtS: 47
GCID: GC03P047299
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kelch-like family member 18(Previous name: kelch-like 18 (Drosophila) )
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Aliases
for KLHL18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 181 2 | | KIAA07951 3 | | FLJ137031 | | Kelch-Like 18 (Drosophila)1 | | Kelch-Like Protein 182 |
Export aliases for KLHL18 gene to outside databases |
Summaries
for KLHL18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for KLHL18
|
Genomic Views
for KLHL18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL18 gene promoter:
AML1a GCNF AP-4 Ik-3 c-Ets-1 PPAR-alpha AREB6 FOXO4 GCNF-1 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21KLHL18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P047299: view genomic region
(about GC identifiers)
Start:
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47,324,330 bp from pter |
End:
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47,388,306 bp from pter |
Size:
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63,977 bases |
Orientation:
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plus strand |
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Proteins
for KLHL18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLH18_HUMAN, O94889 (See
protein sequence)Recommended Name: Kelch-like protein 18 Size: 574 amino acids; 63638 Da
Sequence caution: Sequence=AAH32620.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAD97920.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K612 Q7Z3E8 Q8N125Alternative splicing: 2 isoforms: O94889-1 O94889-2 Explore the universe of human proteins at neXtProt for KLHL18: NX_O94889
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94889
KLHL18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079286.2
ENSEMBL proteins: ENSP00000407114 ENSP00000411839 ENSP00000232766 ENSP00000392507 ENSP00000405585
Human Recombinant Protein Products:
KLHL18 Antibody Products:
Assay Products for KLHL18: |
Protein
Domains /
Families
for KLHL18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHL18 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O94889ProtoNet protein and cluster: O94889 1 Blocks protein family: IPB000210 BTB/POZ domain
UniProtKB/Swiss-Prot: KLH18_HUMAN, O94889Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats |
Function
for KLHL18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLHL18 (NM_025010) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL18 |
1 GenomeRNAi human phenotype for KLHL18:
|
Pathways & Interactions
for KLHL18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL18
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5 Interacting proteins for KLHL18 (O948893 ENSP000002327664) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KLHL18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL18
Search CenterWatch for drugs/clinical trials and news about KLHL18 / KLH18
|
Transcripts
for KLHL18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL18 gene: NM_025010.4 Unigene Cluster for KLHL18: Kelch-like 18 (Drosophila) Hs.517946 [show with all ESTs]Unigene Representative Sequence: AB0624787 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000433449 ENST00000437353 ENST00000461084(uc003crc.2 uc010hjq.2)
ENST00000232766(uc003crd.3 uc011bav.2) ENST00000442272 ENST00000483201(uc003crb.2)
ENST00000455924
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL18
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHL18 (NM_025010) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL18 |
Additional cDNA sequence: AB018338.1 AB062478.1 AK001337.1 AK023765.1 AK291477.1 AK295292.1 AY714879.1 BC015962.1 BC016388.2 BC032620.1 BX537953.1 9 DOTS entries: DT.215035 DT.100775202 DT.100775198 DT.75131759 DT.102831744 DT.97841631 DT.100651272 DT.91858701 DT.97815828 24/144 AceView cDNA sequences (see all 144): AI867863 T34063 AI754328 AW500390 AW151264 AU280345 BU172490 AA489670 CA398204 Z38488 AI356423 BU625052 AW083400 CA398203 AB062478 AB018338 AA301842 BQ436073 BM976127 BM452344 BM673613 AW241674 AI630602 CA309636
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL18 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 | ^ | 13 | ^ | 14 |
|---|
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| SP1: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KLHL18
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Expression
for KLHL18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTTTGTGT
About this image
See KLHL18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL18
SOURCE GeneReport for Unigene cluster: Hs.517946
SABiosciences Custom PCR Arrays for KLHL18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL18 |
Orthologs
for KLHL18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KLHL18 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for KLHL18 (if available)
TreeFam Gene Tree for KLHL18 (if available) |
Paralogs
for KLHL18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL18 gene
- KLHL172 KLHL202 KLHL52 KLHL122 KEAP12 KLHL282 KLHL42 IPP2
- KLHL32 KLHL82 KLHL102 KLHL12 KLHL22
18/49 SIMAP similar genes for KLHL18 using alignment to 8 protein entries: KLH18_HUMAN (see all proteins)
(see all similar genes):ZBTB4 ZBTB44 KLHL20 KLHL17 KLHL3 KBTBD8
KLHL12 KLHL8 KLHL1 KLHL5 ZBTB10 ZBTB16
KEAP1 DKFZp686P15123 KLHL4 KLHL28 KLHL2 DKFZp686H07112
KLHL18 for paralogs About GeneDecksing
|
Genomic Variants
for KLHL18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHL18 (47324330 - 47388306 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KLHL18
1 Indel: 46414 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL18 |
|
Disorders
/ Diseases
for KLHL18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KLHL18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL18 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with KLHL18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- An interaction network of the mammalian COP9 signalos ome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)1 Olma M.H....Pintard L. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
|
External Searches for KLHL18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLHL18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL18 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KLHL18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLHL18 gene:
Search GeneIP for patents involving KLHL18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLHL18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL18 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLHL18 | | OriGene 3'-UTR Clone for KLHL18 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KLHL18 | | OriGene Custom Protein Services for KLHL18 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL18 |
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| | | | Search Tocris compounds for KLHL18 |
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 | | | KLHL18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL18 |
|  |  |  | | | | ThermoFisher Antibody for KLHL18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL18 |
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