Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL18 Gene

protein-coding   GIFtS: 48
GCID: GC03P047299

Kelch-Like Family Member 18

(Previous name: kelch-like 18 (Drosophila))
  Search for KLHL18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 181 2
Kelch-Like 18 (Drosophila)1
Kelch-Like Protein 182
KIAA07953

External Ids:    HGNC: 291201   Entrez Gene: 232762   Ensembl: ENSG000001146487   UniProtKB: O948893   

Export aliases for KLHL18 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLHL18 Gene: 
KLHL18 (kelch-like family member 18) is a protein-coding gene. An important paralog of this gene is KLHL17.

Gene Wiki entry for KLHL18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL18 gene promoter:
         AML1a   GCNF   AP-4   Ik-3   c-Ets-1   PPAR-alpha   AREB6   FOXO4   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL18 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHL18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

KLHL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL18 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P047299:  view genomic region     (about GC identifiers)

Start:
47,324,330 bp from pter      End:
47,388,306 bp from pter
Size:
63,977 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLH18_HUMAN, O94889 (See protein sequence)
Recommended Name: Kelch-like protein 18  
Size: 574 amino acids; 63638 Da
Sequence caution: Sequence=AAH32620.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD97920.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K612 Q7Z3E8 Q8N125
Alternative splicing: 2 isoforms:  O94889-1   O94889-2   

Explore the universe of human proteins at neXtProt for KLHL18: NX_O94889

Explore proteomics data for KLHL18 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94889

  • KLHL18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL18 Protein Expression
    REFSEQ proteins: NP_079286.2  
    ENSEMBL proteins: 
     ENSP00000407114   ENSP00000411839   ENSP00000232766   ENSP00000392507   ENSP00000405585  

    Human Recombinant Protein Products for KLHL18: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KLHL18
    GenScript Custom Purified and Recombinant Proteins Services for KLHL18
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLHL18 


    KLHL18 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLHL18
    GenScript Custom Superior Antibodies Services for KLHL18
    Novus Biologicals KLHL18 Antibodies
    Abcam antibodies for KLHL18
    Cloud-Clone Corp. Antibodies for KLHL18 
    ThermoFisher Antibody for KLHL18
    LSBio Antibodies in human, mouse, rat for KLHL18 

    Assay Products for KLHL18: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLHL18
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLHL18
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLHL18 
    Cloud-Clone Corp. CLIAs for KLHL18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    5/7 InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry O94889

    ProtoNet protein and cluster: O94889

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: KLH18_HUMAN, O94889
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KLHL18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL18:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL18 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL18 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL18 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL18
    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL18 (see all 83):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-3916 hsa-miR-1243 hsa-miR-3909 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidKLHL18 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLHL18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLHL18
    Sirion Biotech Customized adenovirus for overexpression of KLHL18

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KLHL18 (see all 8)
    OriGene ORF clones in mouse, rat for KLHL18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL18 (NM_025010)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL18
    Sirion Biotech Customized lentivirus for stable overexpression of KLHL18 
                         Customized lentivirus expression plasmids for stable overexpression of KLHL18 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLHL18
    Search LifeMap BioReagents cell lines for KLHL18
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL18


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL18

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5 Interacting proteins for KLHL18 (O948893 ENSP000002327664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    COPS6Q7L5N13, ENSP000003041024I2D: score=1 STRING: ENSP00000304102
    EEF1GP266413I2D: score=2 
    RBL1P287493I2D: score=1 
    TRIM37O949723I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL18 (KLH18)

    Search CenterWatch for drugs/clinical trials and news about KLHL18 / KLH18

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL18 gene: 
    NM_025010.4  

    Unigene Cluster for KLHL18:

    Kelch-like family member 18
    Hs.517946  [show with all ESTs]
    Unigene Representative Sequence: AB062478
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433449 ENST00000437353 ENST00000461084(uc003crc.2 uc010hjq.2)
    ENST00000232766(uc003crd.3 uc011bav.2) ENST00000442272 ENST00000483201(uc003crb.2)
    ENST00000455924
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL18
    8/83 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL18 (see all 83):
    hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-128 hsa-miR-3916 hsa-miR-1243 hsa-miR-3909 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidKLHL18 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLHL18
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL18
    Clone
    Products:
         
    OriGene clones in human, mouse for KLHL18 (see all 8)
    OriGene ORF clones in mouse, rat for KLHL18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL18 (NM_025010)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL18
    Sirion Biotech Customized lentivirus for stable overexpression of KLHL18 
                         Customized lentivirus expression plasmids for stable overexpression of KLHL18 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL18
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL18
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL18
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL18

    Additional mRNA sequence: 

    AB018338.1 AB062478.1 AK001337.1 AK023765.1 AK291477.1 AK295292.1 AY714879.1 BC015962.1 
    BC016388.2 BC032620.1 BX537953.1 

    9 DOTS entries:

    DT.215035  DT.100775202  DT.100775198  DT.75131759  DT.102831744  DT.97841631  DT.100651272  DT.91858701 
    DT.97815828 

    24/144 AceView cDNA sequences (see all 144):

    AU280345 BU625052 BM142120 AI754328 AA489670 AI147462 AW151264 AI630602 
    BM976127 BM696639 BQ436073 AW083400 AW241674 AB018338 AI356423 BU172490 
    AB062478 CA398203 AI867863 CA309636 T34063 AW500390 CA398204 BM452344 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL18 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14
    SP1:              -     -     -     -                                                                 -                 -                     
    SP2:                                                                                                  -                 -                     
    SP3:              -     -     -     -                                                                 -                                       
    SP4:                                                                                                                                          
    SP5:              -           -     -                                                                                                         


    ECgene alternative splicing isoforms for KLHL18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTTGTGT
    KLHL18 Expression
    About this image


    See KLHL18 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL18

    SOURCE GeneReport for Unigene cluster: Hs.517946
        SABiosciences Custom PCR Arrays for KLHL18
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL18
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL18
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL18
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLHL18 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl181 , 5 kelch-like 18 (Drosophila)1, 5 91.11(n)1
    98.43(a)1
      9 (59.92 cM)5
    2702011  NM_177771.51  NP_808439.21 
     1104259285 
    chicken
    (Gallus gallus)
    Aves KLHL181 kelch-like 18 (Drosophila) 83.54(n)
    92.39(a)
      420406  NM_001030960.2  NP_001026131.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL186
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343865.1(112865-143431)
    zebrafish
    (Danio rerio)
    Actinopterygii wufi18c082 wufi18c08 76.83(n)   327574  BC045319.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta KLHL181 CG3571-PA 57.39(n)
    53.7(a)
      41458  NM_141886.2  NP_650143.1 
    worm
    (Caenorhabditis elegans)
    Secernentea kel-31 Protein KEL-3 49.94(n)
    45.45(a)
      176775  NM_067383.3  NP_499784.2 


    ENSEMBL Gene Tree for KLHL18 (if available)
    TreeFam Gene Tree for KLHL18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL18 gene
    KLHL172  KLHL202  KLHL52  KLHL122  KEAP12  KLHL282  KLHL42  KLHL32  
    IPP2  KLHL82  KLHL102  KLHL12  KLHL22  
    18/49 SIMAP similar genes for KLHL18 using alignment to 8 protein entries:     KLH18_HUMAN (see all proteins) (see all similar genes):
    ZBTB4    ZBTB44    KLHL20    KLHL17    KLHL3    KBTBD8
    KLHL12    KLHL8    KLHL1    ZBTB16    KEAP1    KLHL5
    DKFZp686P15123    KLHL4    KLHL2    KLHL28    ZBTB45    DKFZp686H07112

    KLHL18 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1085 SNPs in KLHL18 are shown (see all 1085)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs556958491,2
    C--47341345(+) AAAAA-/A/AA  
            
    GATTG
    1 -- int11NA 2
    rs668672181,2
    C--47357256(-) TTTCC-/TGAGA 
            
    TATTT
    1 -- int12Minor allele frequency- TGAGA:0.25NA 4
    rs716154601,2
    C--47358217(+) TGTGTA/GTATAT 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1132952841,2
    C,F--47365401(+) CACCCG/ATCTTG 1 -- us2k12Minor allele frequency- A:0.01CSA EU 570
    rs1147175131,2
    F--47365504(+) ACGTCG/ACTTCA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1900093491,2
    --47365515(+) TTTGAA/GTGGGT 1 -- us2k10--------
    rs8079361,2
    C,F,O,A,H--47365528(+) CAGTTC/TCCAAA 1 -- us2k127Minor allele frequency- T:0.47NA NS EA WA CSA 2496
    rs1448860361,2
    --47365535(+) CAAAAC/TTAAAT 1 -- us2k10--------
    rs1928388201,2
    --47365569(+) TTGTGC/TTTTTT 1 -- us2k10--------
    rs1848526451,2
    --47365621(+) GCACAA/GAGTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLHL18 (47324330 - 47388306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLHL18:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2417653CNV Deletion18987734
    nsv428417CNV Loss18775914
    nsv876756CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL18
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL18 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with KLHL18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    5. An interaction network of the mammalian COP9 signalos ome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)1 Olma M.H....Pintard L. (2009)
    6. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    9. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    10. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23276 HGNC: 29120 AceView: KLHL18 Ensembl:ENSG00000114648 euGenes: HUgn23276
    ECgene: KLHL18 H-InvDB: KLHL18

    (According to HUGE)
    About This Section
    HUGE: KIAA0795

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL18 gene:
    Search GeneIP for patents involving KLHL18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLHL18  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KLHL18  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLHL18   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KLHL18   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLHL18   OriGene Custom Protein Services for KLHL18  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL18
     QIAGEN SeqTarget long-range PCR primers for resequencing KLHL18
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL18
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL18
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL18
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL18
     GenScript Custom Purified and Recombinant Proteins Services for KLHL18 GenScript cDNA clones with any tag delivered in your preferred vector for KLHL18
     GenScript Custom Assay Services for KLHL18 GenScript Custom Superior Antibodies Services for KLHL18
     GenScript Custom overexpressing Cell Line Services for KLHL18 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLHL18 promoter
     Search Chromatin IP Primers for KLHL18
     RT2 qPCR Primer Assay in human, mouse, rat KLHL18
     Search GNC Networks for KLHL18
     SABiosciences Custom PCR Arrays for KLHL18
     Search Tocris compounds for KLHL18 (KLH18)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLHL18 antibodies
     Antibodies for KLHL18
     See all of Abcam's Antibodies, Kits and Proteins for KLHL18
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for KLHL18
     Antibodies for KLHL18
     ELISAs for KLHL18
     CLIAs for KLHL18
     Search LifeMap BioReagents cell lines for KLHL18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL18
     SwitchGear 3'UTR luciferase reporter plasmids for KLHL18
     SwitchGear Promoter luciferase reporter plasmids for KLHL18
     ThermoFisher Antibody for KLHL18
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL18
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL18
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL18
    Customized:
     lentivirus for stable overexpression of KLHL18
     lentivirus expression plasmids for stable overexpression of KLHL18
     adenovirus for overexpression of KLHL18
     LSBio Antibodies in human, mouse, rat for KLHL18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLHL18 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4