Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL17 Gene

protein-coding   GIFtS: 45
GCID: GC01P000885

Kelch-Like Family Member 17

(Previous name: kelch-like 17 (Drosophila))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 171 2     Kelch-Like 172
actinfilin1 2     Kelch-Like Protein 172
Kelch-Like 17 (Drosophila)1     Actinfilin3
RP11-54O7.62     

External Ids:    HGNC: 240231   Entrez Gene: 3394512   Ensembl: ENSG000001879617   UniProtKB: Q6TDP43   

Export aliases for KLHL17 gene to outside databases

Previous GC identifers: GC01P000936 GC01P000166


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLHL17 Gene:
The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal
BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to
F-actin. This protein may play a key role in the regulation of actin-based neuronal function. (provided by
RefSeq, Aug 2010)

GeneCards Summary for KLHL17 Gene: 
KLHL17 (kelch-like family member 17) is a protein-coding gene. Diseases associated with KLHL17 include neuronitis. GO annotations related to this gene include actin filament binding and POZ domain binding. An important paralog of this gene is KLHL18.

UniProtKB/Swiss-Prot: KLH17_HUMAN, Q6TDP4
Function: Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein
ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role
in the actin-based neuronal function (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL17 gene promoter:
         CREB   Max   Max1   deltaCREB   XBP-1   YY1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL17 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHL17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

KLHL17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL17 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P000885:  view genomic region     (about GC identifiers)

Start:
895,967 bp from pter      End:
901,099 bp from pter
Size:
5,133 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLH17_HUMAN, Q6TDP4 (See protein sequence)
Recommended Name: Kelch-like protein 17  
Size: 642 amino acids; 69874 Da
Subunit: Interacts with F-actin; the interaction disruptes the F-actin structures and leads to marked changes of
neuronal morphology. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts
directly with PDZK1 (via PDZ1 domain); the interaction is important for integrity of actin cytoskeleton
structures in neurons. Interacts with DLG4 and SYNGAP1. Interacts (via kelch repeats) with GRIK2 (via
C-terminus); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway. Interacts with
GRIK1. Interacts with (via BTB domain) CUL3; the interaction regulates surface GRIK2 expression (By similarity)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity).
Cell junction, synapse (By similarity). Note=Postsynaptic density (By similarity)
Secondary accessions: Q5SV94

Explore the universe of human proteins at neXtProt for KLHL17: NX_Q6TDP4

Explore proteomics data for KLHL17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6TDP4

  • KLHL17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL17 Protein Expression
    REFSEQ proteins: NP_938073.1  
    ENSEMBL proteins: 
     ENSP00000343930   ENSP00000463694  

    Human Recombinant Protein Products for KLHL17: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KLHL17
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for KLHL17
    GenScript Custom Purified and Recombinant Proteins Services for KLHL17
    Novus Biologicals KLHL17 Protein
    Novus Biologicals KLHL17 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0014069postsynaptic density IEA--
    GO:0015629actin cytoskeleton ISS--
    GO:0030054cell junction IEA--
    GO:0032839dendrite cytoplasm IEA--

    KLHL17 for ontologies           About GeneDecksing



    KLHL17 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLHL17
    GenScript Custom Superior Antibodies Services for KLHL17
    Novus Biologicals KLHL17 Antibodies
    Abcam antibodies for KLHL17
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for KLHL17
    Search LSBio for Antibodies for KLHL17 

    Assay Products for KLHL17: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLHL17
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLHL17
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    5/7 InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q6TDP4

    ProtoNet protein and cluster: Q6TDP4

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH17_HUMAN, Q6TDP4
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH17_HUMAN, Q6TDP4
    Function: Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein
    ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role
    in the actin-based neuronal function (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0031208POZ domain binding IEA--
    GO:0032947protein complex scaffold ISS--
    GO:0051015actin filament binding IEA--
         
    KLHL17 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL17 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL17 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL17 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL17
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL17 (see all 10):
    hsa-miR-3910 hsa-miR-137 hsa-miR-124 hsa-miR-654-5p hsa-miR-19b hsa-miR-506 hsa-miR-19a hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL17 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLHL17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL17

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLHL17
    Sirion Biotech Customized adenovirus for overexpression of KLHL17

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for KLHL17 (see all 7)
    OriGene ORF clones in mouse, rat for KLHL17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL17 (NM_198317)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL17
    Sirion Biotech Customized lentivirus for stable overexpression of KLHL17 
                         Customized lentivirus expression plasmids for stable overexpression of KLHL17 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLHL17
    Search LifeMap BioReagents cell lines for KLHL17
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL17


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: KLH17_HUMAN, Q6TDP4
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL17

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for KLHL17 (Q6TDP43 ENSP000003439304) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTC1P680323, ENSP000002903784I2D: score=1 STRING: ENSP00000290378
    ENSG00000227460Q96PV03I2D: score=1 
    SYNGAP1Q96PV03I2D: score=1 
    ACTBP607093I2D: score=1 
    DLG4P783523I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007420brain development IEA--
    GO:0016567protein ubiquitination IEA--
    GO:0030036actin cytoskeleton organization ISS--

    KLHL17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL17 (KLH17)

    Search CenterWatch for drugs/clinical trials and news about KLHL17 / KLH17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL17 gene: 
    NM_198317.2  

    Unigene Cluster for KLHL17:

    Kelch-like family member 17
    Hs.109212  [show with all ESTs]
    Unigene Representative Sequence: NM_198317
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338591(uc001aca.2) ENST00000463212(uc001acb.1 uc010nya.1)
    ENST00000466300 ENST00000481067
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL17
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL17 (see all 10):
    hsa-miR-3910 hsa-miR-137 hsa-miR-124 hsa-miR-654-5p hsa-miR-19b hsa-miR-506 hsa-miR-19a hsa-miR-30b*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL17 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for KLHL17
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL17
    Clone
    Products:
         
    OriGene clones in human, mouse for KLHL17 (see all 7)
    OriGene ORF clones in mouse, rat for KLHL17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL17 (NM_198317)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL17
    Sirion Biotech Customized lentivirus for stable overexpression of KLHL17 
                         Customized lentivirus expression plasmids for stable overexpression of KLHL17 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL17
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL17
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL17
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL17

    Additional mRNA sequence: 

    AK127585.1 AK293258.1 AY423763.1 BC033192.1 BC045768.1 BC105742.1 

    7 DOTS entries:

    DT.100706932  DT.95256710  DT.101981933  DT.100748864  DT.97825011  DT.100741610  DT.99954446 

    24/63 AceView cDNA sequences (see all 63):

    AY423763 CA489312 NM_198317 BX108296 BX402912 BM773087 AL536811 AA308909 
    CA314565 BM728025 AI150576 BM742493 BQ002785 BM932272 BC033192 BM849888 
    AK127585 BQ027734 BM765088 BM847622 AA774437 BM741506 BC045768 BM806379 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL17 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                                -     -                             -                       -                                             
    SP2:                                                                                            -                       -                     
    SP3:                                                                                                                                          
    SP4:                                                                                                                    -                     
    SP5:                                                                    -                                                                     


    ECgene alternative splicing isoforms for KLHL17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGGGTCCC
    KLHL17 Expression
    About this image


    See KLHL17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL17

    SOURCE GeneReport for Unigene cluster: Hs.109212
        SABiosciences Custom PCR Arrays for KLHL17
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL17
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL17
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL17
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL17
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLHL17 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl171 , 5 kelch-like 17 (Drosophila)1, 5 86.93(n)1
    98.12(a)1
      4 (88.63 cM)5
    2310031  NM_198305.21  NP_938047.11 
     1562290445 
    chicken
    (Gallus gallus)
    Aves KLHL171 kelch-like 17 (Drosophila) 82.43(n)
    91.53(a)
      419432  XM_417591.2  XP_417591.2 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL176
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343334.1(803479-820296)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.23532 Xenopus laevis transcribed sequence with weak similarity more 75.04(n)    48026223 
    zebrafish
    (Danio rerio)
    Actinopterygii klhl171 kelch-like 17 (Drosophila) 78.25(n)
    90(a)
      336187  XM_003201200.1  XP_003201248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG150971 CG15097 59.52(n)
    56.58(a)
      37172  NM_001202044.1  NP_001188973.1 


    ENSEMBL Gene Tree for KLHL17 (if available)
    TreeFam Gene Tree for KLHL17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL17 gene
    KLHL182  KLHL202  KLHL52  KLHL122  KEAP12  KLHL282  KLHL42  KLHL32  
    IPP2  KLHL82  KLHL102  KLHL12  KLHL22  
    18/36 SIMAP similar genes for KLHL17 using alignment to 4 protein entries:     KLH17_HUMAN (see all proteins) (see all similar genes):
    KLHL20    BACH2    KLHL3    KLHL1    KLHL2    KBTBD8
    DKFZp686P15123    KBTBD7    KLHL5    KLHL4    KLHL28    KLHL18
    DKFZp761P1717    KLHL32    KLHL8    KLHL12    DKFZp686H07112    KLHL21

    KLHL17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/392 SNPs in KLHL17 are shown (see all 392)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs284153731,2
    C,F,H--880802(+) TCAGCC/TCCTCT 1 -- us2k17Minor allele frequency- T:0.01NS NA CSA WA 1036
    rs1392962811,2
    --880815(+) CCTTCC/TTTTCC 1 -- us2k10--------
    rs1138070531,2
    --880821(+) TTTCCG/CTCCCC 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1841865121,2
    --880862(+) GCGGTG/TATTTC 1 -- us2k10--------
    rs1886916151,2
    --880923(+) TCACCA/TACATA 1 -- us2k10--------
    rs1922905411,2
    --880989(+) TGAAAA/GAGTAA 1 -- us2k10--------
    rs1828621791,2
    --880991(+) AAAGAA/GTAAGT 1 -- us2k10--------
    rs1442170191,2
    C,F--881151(+) CGCCCG/AGCTTA 1 -- us2k12Minor allele frequency- A:0.00NA EU 4345
    rs2010784041,2
    --881177(+) GCCTCA/GCGTGC 1 -- us2k10--------
    rs2000367351,2
    C--881203(+) TTGTGA/GAGAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLHL17 (895967 - 901099 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for KLHL17 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726139CNV Deletion23290073
    esv2727250CNV Deletion23290073
    esv2725028CNV Deletion23290073
    esv1003697CNV Deletion20482838
    nsv509035CNV Insertion20534489
    nsv159315CNV Loss16902084
    dgv9n71CNV Loss21882294
    dgv10n71CNV Loss21882294
    nsv870660CNV Loss21882294
    dgv11n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing KLHL17
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for KLHL17:    About MalaCards
    neuronitis    


    KLHL17 for disorders           About GeneDecksing


    Export disorders for KLHL17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL17 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KLHL17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Actinfilin, a brain-specific actin-binding protein in postsynaptic density. (PubMed id 12063253)1, 3 Chen Y....Li M. (2002)
    3. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    6. Interactions between CAP70 and actinfilin are importa nt for integrity of actin cytoskeleton structures in neurons. (PubMed id 16054660)9 Chen Y. and Li M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339451 HGNC: 24023 AceView: KLHL17 Ensembl:ENSG00000187961 euGenes: HUgn339451
    ECgene: KLHL17 H-InvDB: KLHL17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL17 gene:
    Search GeneIP for patents involving KLHL17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLHL17  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KLHL17  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KLHL17  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLHL17   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KLHL17   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLHL17   OriGene Custom Protein Services for KLHL17  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL17
     QIAGEN SeqTarget long-range PCR primers for resequencing KLHL17
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL17
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL17
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL17
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL17
     GenScript Custom Purified and Recombinant Proteins Services for KLHL17 GenScript cDNA clones with any tag delivered in your preferred vector for KLHL17
     GenScript Custom Assay Services for KLHL17 GenScript Custom Superior Antibodies Services for KLHL17
     GenScript Custom overexpressing Cell Line Services for KLHL17 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLHL17 promoter
     Search Chromatin IP Primers for KLHL17
     RT2 qPCR Primer Assay in human, mouse, rat KLHL17
     Search GNC Networks for KLHL17
     SABiosciences Custom PCR Arrays for KLHL17
     Search Tocris compounds for KLHL17 (KLH17)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLHL17 antibodies
     KLHL17 proteins
     KLHL17 lysates
     Antibodies for KLHL17
     See all of Abcam's Antibodies, Kits and Proteins for KLHL17
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for KLHL17
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL17
     SwitchGear 3'UTR luciferase reporter plasmids for KLHL17
     SwitchGear Promoter luciferase reporter plasmids for KLHL17
     ThermoFisher Antibodies for KLHL17
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL17
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL17
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL17
    Customized:
     lentivirus for stable overexpression of KLHL17
     lentivirus expression plasmids for stable overexpression of KLHL17
     adenovirus for overexpression of KLHL17
     Search LSBio for Antibodies for KLHL17
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLHL17 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4