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KLHL17 Gene

protein-coding   GIFtS: 45
GCID: GC01P000885

Kelch-Like Family Member 17

(Previous name: kelch-like 17 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 171 2
actinfilin1 2
Kelch-Like 17 (Drosophila)1
Kelch-Like 172
Kelch-Like Protein 172
Actinfilin3

External Ids:    HGNC: 240231   Entrez Gene: 3394512   Ensembl: ENSG000001879617   UniProtKB: Q6TDP43   

Export aliases for KLHL17 gene to outside databases

Previous GC identifers: GC01P000936 GC01P000166


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLHL17 Gene:
The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal
BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to
F-actin. This protein may play a key role in the regulation of actin-based neuronal function. (provided by
RefSeq, Aug 2010)

GeneCards Summary for KLHL17 Gene:
KLHL17 (kelch-like family member 17) is a protein-coding gene. Diseases associated with KLHL17 include neuronitis, and malaria. GO annotations related to this gene include actin filament binding and POZ domain binding. An important paralog of this gene is KLHL18.

UniProtKB/Swiss-Prot: KLH17_HUMAN, Q6TDP4
Function: Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein
ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role
in the actin-based neuronal function (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL17 gene promoter:
         CREB   Max   Max1   deltaCREB   XBP-1   YY1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL17 promoter sequence
   Search Chromatin IP Primers for KLHL17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36

KLHL17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL17 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P000885:  view genomic region     (about GC identifiers)

Start:
895,967 bp from pter      End:
901,099 bp from pter
Size:
5,133 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLH17_HUMAN, Q6TDP4 (See protein sequence)
Recommended Name: Kelch-like protein 17  
Size: 642 amino acids; 69874 Da
Subunit: Interacts with F-actin; the interaction disruptes the F-actin structures and leads to marked changes of
neuronal morphology. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts
directly with PDZK1 (via PDZ1 domain); the interaction is important for integrity of actin cytoskeleton
structures in neurons. Interacts with DLG4 and SYNGAP1. Interacts (via kelch repeats) with GRIK2 (via
C-terminus); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway. Interacts with
GRIK1. Interacts with (via BTB domain) CUL3; the interaction regulates surface GRIK2 expression (By similarity)
Secondary accessions: Q5SV94

Explore the universe of human proteins at neXtProt for KLHL17: NX_Q6TDP4

Explore proteomics data for KLHL17 at MOPED


See KLHL17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_938073.1  
ENSEMBL proteins: 
 ENSP00000343930   ENSP00000463694  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
BTBD: BTB/POZ domain containing
KLHL: Kelch-like

Selected InterPro protein domains (see all 8):
 IPR011043 Gal_Oxase/kelch_b-propeller
 IPR006652 Kelch_1
 IPR011333 BTB/POZ_fold
 IPR017096 Kelch-like_gigaxonin-typ
 IPR015916 Gal_Oxidase_b-propeller

Graphical View of Domain Structure for InterPro Entry Q6TDP4

ProtoNet protein and cluster: Q6TDP4

2 Blocks protein domains:
IPB000210 BTB/POZ domain
IPB011705 BTB/Kelch-associated


UniProtKB/Swiss-Prot: KLH17_HUMAN, Q6TDP4
Similarity: Contains 1 BACK (BTB/Kelch associated) domain
Similarity: Contains 1 BTB (POZ) domain
Similarity: Contains 6 Kelch repeats


KLHL17 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: KLH17_HUMAN, Q6TDP4
Function: Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein
ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role
in the actin-based neuronal function (By similarity)

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0031208POZ domain binding IEA--
GO:0032947protein complex scaffold ISS--
GO:0051015actin filament binding IEA--
     
KLHL17 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL17
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miRNA
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miRTarBase miRNAs that target KLHL17:
hsa-mir-335-5p (MIRT018687)

Block miRNA regulation of human, mouse, rat KLHL17 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KLHL17 (see all 10):
hsa-miR-3910 hsa-miR-137 hsa-miR-124 hsa-miR-654-5p hsa-miR-19b hsa-miR-506 hsa-miR-19a hsa-miR-30b*
SwitchGear 3'UTR luciferase reporter plasmidKLHL17 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat KLHL17

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL17

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
KLH17_HUMAN, Q6TDP4: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity).
Cell junction, synapse (By similarity). Note=Postsynaptic density (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton4
cytosol3
nucleus3
plasma membrane3

Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IDA--
GO:0014069postsynaptic density IEA--
GO:0015629actin cytoskeleton ISS--
GO:0030054cell junction IEA--
GO:0032839dendrite cytoplasm IEA--

KLHL17 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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UniProtKB/Swiss-Prot: KLH17_HUMAN, Q6TDP4
Pathway: Protein modification; protein ubiquitination

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL17
Interactions:

    Search GeneGlobe Interaction Network for KLHL17

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for KLHL17 (Q6TDP43 ENSP000003439304) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

InteractantInteraction Details
GeneCardExternal ID(s)
ENSG00000227460Q96PV03, ENSP000004142594I2D: score=1 STRING: ENSP00000414259
SYNGAP1Q96PV03, ENSP000004036364I2D: score=1 STRING: ENSP00000403636
ACTC1P680323, ENSP000002903784I2D: score=1 STRING: ENSP00000290378
PDZK1Q5T2W13, ENSP000003421434I2D: score=1 STRING: ENSP00000342143
ACTBP607093I2D: score=1 
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007420brain development IEA--
GO:0016567protein ubiquitination IEA--
GO:0030036actin cytoskeleton organization ISS--

KLHL17 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for KLHL17 (KLH17)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for KLHL17 gene: 
NM_198317.2  

Unigene Cluster for KLHL17:

Kelch-like family member 17
Hs.109212  [show with all ESTs]
Unigene Representative Sequence: NM_198317
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000338591(uc001aca.2) ENST00000463212(uc001acb.1 uc010nya.1)
ENST00000466300 ENST00000481067
miRNA
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Block miRNA regulation of human, mouse, rat KLHL17 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KLHL17 (see all 10):
hsa-miR-3910 hsa-miR-137 hsa-miR-124 hsa-miR-654-5p hsa-miR-19b hsa-miR-506 hsa-miR-19a hsa-miR-30b*
SwitchGear 3'UTR luciferase reporter plasmidKLHL17 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for KLHL17
Predesigned siRNA for gene silencing in human, mouse, rat KLHL17
Clone
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OriGene ORF clones in mouse, rat for KLHL17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: KLHL17 (NM_198317)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL17
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL17
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for KLHL17
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL17
  QuantiTect SYBR Green Assays in human, mouse, rat KLHL17
  QuantiFast Probe-based Assays in human, mouse, rat KLHL17

Additional mRNA sequence: 

AK127585.1 AK293258.1 AY423763.1 BC033192.1 BC045768.1 BC105742.1 

7 DOTS entries:

DT.100706932  DT.95256710  DT.101981933  DT.100748864  DT.97825011  DT.100741610  DT.99954446 

Selected AceView cDNA sequences (see all 63):

BX108296 AY423763 NM_198317 BX402912 BM773087 CA489312 BM765088 BM847622 
BM932272 BQ027734 CA314565 BC045768 AK127585 BM742493 AI150576 BM752566 
BM741506 AL555656 BM849888 BM806379 AA308909 BQ002785 AA774437 AL536811 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLHL17 (see all 7)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1:                                -     -                             -                       -                                             
SP2:                                                                                            -                       -                     
SP3:                                                                                                                                          
SP4:                                                                                                                    -                     
SP5:                                                                    -                                                                     


ECgene alternative splicing isoforms for KLHL17

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KLHL17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCGGGGTCCC
KLHL17 Expression
About this image

KLHL17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KLHL17 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.109212
    Custom PCR Arrays for KLHL17
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL17

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for KLHL17 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Klhl171 , 5 kelch-like 17 (Drosophila)5
kelch-like 171
86.46(n)1
97.34(a)1
  4 (88.63 cM)5
2310031  NM_198305.21  NP_938047.11 
 1562290445 
chicken
(Gallus gallus)
Aves KLHL171 kelch-like 17 (Drosophila) 82.43(n)
91.53(a)
  419432  XM_417591.3  XP_417591.2 
lizard
(Anolis carolinensis)
Reptilia KLHL176
kelch-like family member 17
89(a)
1 ↔ 1
GL343334.1(803479-820296)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23532 Xenopus laevis transcribed sequence with weak similarity more 75.04(n)    48026223 
zebrafish
(Danio rerio)
Actinopterygii klhl171 kelch-like 17 (Drosophila) 78.25(n)
90(a)
  336187  XM_005162205.1  XP_005162262.1 
fruit fly
(Drosophila melanogaster)
Insecta CG150971 CG15097 59.39(n)
56.17(a)
  37172  NM_001274150.1  NP_001261079.1 
worm
(Caenorhabditis elegans)
Secernentea kel-16
Protein KEL-1, isoform a
34(a)
1 ↔ 1
II(11688970-11696062) WBGene00002184


ENSEMBL Gene Tree for KLHL17 (if available)
TreeFam Gene Tree for KLHL17 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KLHL17 gene
KLHL182  KLHL202  KLHL52  KLHL122  KEAP12  KLHL282  KLHL42  KLHL32  
KLHL82  KLHL102  KLHL12  KLHL22  
Selected SIMAP similar genes for KLHL17 using alignment to 4 protein entries:     KLH17_HUMAN (see all proteins) (see all similar genes):
KLHL20    BACH2    KLHL3    KLHL1    KLHL2    KBTBD8
DKFZp686P15123    KBTBD7    KLHL5    KLHL4    KLHL28    KLHL18
DKFZp761P1717    KLHL32    KLHL8    KLHL12    DKFZp686H07112    KLHL21

KLHL17 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KLHL17 (see all 392)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs284153731,2
C,F,H--880802(+) TCAGCC/TCCTCT 1 -- us2k17Minor allele frequency- T:0.01NS NA CSA WA 1036
rs1392962811,2
--880815(+) CCTTCC/TTTTCC 1 -- us2k10--------
rs1138070531,2
--880821(+) TTTCCG/CTCCCC 1 -- us2k11Minor allele frequency- C:0.50CSA 2
rs1841865121,2
--880862(+) GCGGTG/TATTTC 1 -- us2k10--------
rs1886916151,2
--880923(+) TCACCA/TACATA 1 -- us2k10--------
rs1922905411,2
--880989(+) TGAAAA/GAGTAA 1 -- us2k10--------
rs1828621791,2
--880991(+) AAAGAA/GTAAGT 1 -- us2k10--------
rs1442170191,2
C,F--881151(+) CGCCCG/AGCTTA 1 -- us2k12Minor allele frequency- A:0.00NA EU 4345
rs2010784041,2
--881177(+) GCCTCA/GCGTGC 1 -- us2k10--------
rs2000367351,2
C--881203(+) TTGTGA/GAGAAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for KLHL17 (895967 - 901099 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for KLHL17 (see all 21):    About this table    
Variant IDTypeSubtypePubMed ID
esv2726139CNV Deletion23290073
esv2727250CNV Deletion23290073
esv2725028CNV Deletion23290073
esv1003697CNV Deletion20482838
nsv509035CNV Insertion20534489
nsv159315CNV Loss16902084
dgv9n71CNV Loss21882294
dgv10n71CNV Loss21882294
nsv870660CNV Loss21882294
dgv11n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing KLHL17
DNA2.0 Custom Variant and Variant Library Synthesis for KLHL17

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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2 diseases for KLHL17:    
About MalaCards
neuronitis    malaria


KLHL17 for disorders           About GeneDecksing


Export disorders for KLHL17 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KLHL17 gene integrated from 10 sources:
(articles sorted by number of sources associating them with KLHL17)
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  1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  2. Actinfilin, a brain-specific actin-binding protein in postsynaptic density. (PubMed id 12063253)1, 3 Chen Y....Li M. (J. Biol. Chem. 2002)
  3. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. (PubMed id )2 
  7. Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons. (PubMed id 16054660)9 Chen Y. and Li M. (Neuropharmacology 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 339451 HGNC: 24023 AceView: KLHL17 Ensembl:ENSG00000187961 euGenes: HUgn339451
ECgene: KLHL17 H-InvDB: KLHL17

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KLHL17 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KLHL17 gene:
Search GeneIP for patents involving KLHL17

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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