Aliases for KLHL17 Gene
External Ids for KLHL17 Gene
Previous GeneCards Identifiers for KLHL17 Gene
The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]
GeneCards Summary for KLHL17 Gene
KLHL17 (Kelch-Like Family Member 17) is a Protein Coding gene. GO annotations related to this gene include actin filament binding and POZ domain binding. An important paralog of this gene is KLHL10.
UniProtKB/Swiss-Prot for KLHL17 Gene
Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).