Aliases for KLHL17 Gene
External Ids for KLHL17 Gene
The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]
GeneCards Summary for KLHL17 Gene
KLHL17 (Kelch-Like Family Member 17) is a Protein Coding gene. GO annotations related to this gene include actin filament binding and POZ domain binding. An important paralog of this gene is KLHL10.
UniProtKB/Swiss-Prot for KLHL17 Gene
Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).