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Aliases for KLHL15 Gene

Aliases for KLHL15 Gene

  • Kelch Like Family Member 15 2 3 5
  • Epididymis Secretory Protein Li 305 3
  • Kelch-Like Family Member 15 3
  • Kelch-Like 15 (Drosophila) 2
  • Kelch-Like 15 3
  • HEL-S-305 3
  • KIAA1677 4

External Ids for KLHL15 Gene

Previous GeneCards Identifiers for KLHL15 Gene

  • GC0XM023364
  • GC0XM023761
  • GC0XM021746

Summaries for KLHL15 Gene

Entrez Gene Summary for KLHL15 Gene

  • This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. [provided by RefSeq, Apr 2009]

GeneCards Summary for KLHL15 Gene

KLHL15 (Kelch Like Family Member 15) is a Protein Coding gene. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL15 Gene

  • Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL15 Gene

Genomics for KLHL15 Gene

Regulatory Elements for KLHL15 Gene

Enhancers for KLHL15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHL15 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL15 Gene

23,983,716 bp from pter
24,027,186 bp from pter
43,471 bases
Minus strand

Genomic View for KLHL15 Gene

Genes around KLHL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL15 Gene

Proteins for KLHL15 Gene

  • Protein details for KLHL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 15
    Protein Accession:
    Secondary Accessions:
    • Q32MN3
    • Q8NDA3
    • Q96BM6
    • Q9C0I6

    Protein attributes for KLHL15 Gene

    604 amino acids
    Molecular mass:
    69775 Da
    Quaternary structure:
    • Interacts with CUL3.

neXtProt entry for KLHL15 Gene

Proteomics data for KLHL15 Gene at MOPED

Post-translational modifications for KLHL15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL15 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KLHL15 Gene

Domains & Families for KLHL15 Gene

Gene Families for KLHL15 Gene

Suggested Antigen Peptide Sequences for KLHL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 5 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KLHL15: view

Function for KLHL15 Gene

Molecular function for KLHL15 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for KLHL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with KLHL15: view
genes like me logo Genes that share phenotypes with KLHL15: view

Animal Model Products

miRNA for KLHL15 Gene

miRTarBase miRNAs that target KLHL15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL15 Gene

Localization for KLHL15 Gene

Subcellular locations from

Jensen Localization Image for KLHL15 Gene COMPARTMENTS Subcellular localization image for KLHL15 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL15 Gene

Pathways & Interactions for KLHL15 Gene

SuperPathways for KLHL15 Gene

No Data Available

UniProtKB/Swiss-Prot Q96M94-KLH15_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for KLHL15 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHL15 Gene

Drugs & Compounds for KLHL15 Gene

No Compound Related Data Available

Transcripts for KLHL15 Gene

mRNA/cDNA for KLHL15 Gene

Unigene Clusters for KLHL15 Gene

Kelch-like family member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL15 Gene

No ASD Table

Relevant External Links for KLHL15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL15 Gene

mRNA expression in normal human tissues for KLHL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHL15 Gene

This gene is overexpressed in Testis (50.0) and Fetal testis (19.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL15 Gene

SOURCE GeneReport for Unigene cluster for KLHL15 Gene Hs.495854

genes like me logo Genes that share expression patterns with KLHL15: view

Protein tissue co-expression partners for KLHL15 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL15 Gene

Orthologs for KLHL15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL15 35
  • 93.43 (n)
  • 98.51 (a)
KLHL15 36
  • 99 (a)
(Canis familiaris)
Mammalia KLHL15 35
  • 93.6 (n)
  • 99.01 (a)
KLHL15 36
  • 99 (a)
(Mus musculus)
Mammalia Klhl15 35
  • 90.84 (n)
  • 99.34 (a)
Klhl15 16
Klhl15 36
  • 99 (a)
(Pan troglodytes)
Mammalia KLHL15 35
  • 99.72 (n)
  • 99.83 (a)
KLHL15 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhl15 35
  • 91.28 (n)
  • 99.34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
-- 36
  • 95 (a)
-- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL15 36
  • 90 (a)
(Gallus gallus)
Aves KLHL15 35
  • 84.44 (n)
  • 94.21 (a)
KLHL15 36
  • 94 (a)
(Anolis carolinensis)
Reptilia KLHL15 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl15 35
  • 78.42 (n)
  • 90.56 (a)
Str.20207 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19515 35
(Danio rerio)
Actinopterygii Dr.28665 35
klhl15 35
  • 72.74 (n)
  • 85.26 (a)
klhl15 36
  • 79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
-- 36
  • 30 (a)
CSA.449 36
  • 27 (a)
Species with no ortholog for KLHL15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL15 Gene

Gene Tree for KLHL15 (if available)
Gene Tree for KLHL15 (if available)

Paralogs for KLHL15 Gene

(11) SIMAP similar genes for KLHL15 Gene using alignment to 2 proteins: Pseudogenes for KLHL15 Gene

genes like me logo Genes that share paralogs with KLHL15: view

Variants for KLHL15 Gene

Sequence variations from dbSNP and Humsavar for KLHL15 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747819253 -- 24,007,320(+) AAACT(C/T)CAACT intron-variant
rs747837487 -- 23,994,627(+) GTATG(A/G)AAAGA intron-variant
rs747838167 -- 23,987,898(+) GCCTC(-/TT)TTTTT utr-variant-3-prime
rs747916137 -- 23,986,285(+) CAAAA(-/AAAC)AAACA utr-variant-3-prime
rs747922695 -- 24,023,893(+) CAATT(C/T)TCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL15 Gene

Variant ID Type Subtype PubMed ID
esv2740010 CNV Deletion 23290073
esv2660439 CNV Deletion 23128226
nsv524256 CNV Gain 19592680
esv22476 CNV Loss 19812545

Variation tolerance for KLHL15 Gene

Residual Variation Intolerance Score: 6.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL15 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL15 Gene

Disorders for KLHL15 Gene

Relevant External Links for KLHL15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHL15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL15 Gene

Publications for KLHL15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Identification and characterization of a novel kelch-like gene KLHL15 in silico. (PMID: 15870933) Yoshida K. (Oncol. Rep. 2005) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3

Products for KLHL15 Gene

Sources for KLHL15 Gene