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Aliases for KLHL15 Gene

Aliases for KLHL15 Gene

  • Kelch-Like Family Member 15 2 3
  • Epididymis Secretory Protein Li 305 3
  • Kelch-Like 15 (Drosophila) 2
  • Kelch-Like Protein 15 3
  • Kelch-Like 15 3
  • HEL-S-305 3
  • KIAA1677 4

External Ids for KLHL15 Gene

Previous GeneCards Identifiers for KLHL15 Gene

  • GC0XM023364
  • GC0XM023761
  • GC0XM021746

Summaries for KLHL15 Gene

Entrez Gene Summary for KLHL15 Gene

  • This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. [provided by RefSeq, Apr 2009]

GeneCards Summary for KLHL15 Gene

KLHL15 (Kelch-Like Family Member 15) is a Protein Coding gene. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL15 Gene

  • Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL15 Gene

Genomics for KLHL15 Gene

Regulatory Elements for KLHL15 Gene

Genomic Location for KLHL15 Gene

23,983,716 bp from pter
24,027,186 bp from pter
43,471 bases
Minus strand

Genomic View for KLHL15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL15 Gene

Proteins for KLHL15 Gene

  • Protein details for KLHL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 15
    Protein Accession:
    Secondary Accessions:
    • Q32MN3
    • Q8NDA3
    • Q96BM6
    • Q9C0I6

    Protein attributes for KLHL15 Gene

    604 amino acids
    Molecular mass:
    69775 Da
    Quaternary structure:
    • Interacts with CUL3.

neXtProt entry for KLHL15 Gene

Proteomics data for KLHL15 Gene at MOPED

Post-translational modifications for KLHL15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL15 Gene

Domains for KLHL15 Gene

Gene Families for KLHL15 Gene

  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96M94
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KLHL15: view

Function for KLHL15 Gene

Molecular function for KLHL15 Gene

UniProtKB/Swiss-Prot Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for KLHL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL15: view

Phenotypes for KLHL15 Gene

GenomeRNAi human phenotypes for KLHL15:
genes like me logo Genes that share phenotypes with KLHL15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHL15 Gene

Localization for KLHL15 Gene

Subcellular locations from

Jensen Localization Image for KLHL15 Gene COMPARTMENTS Subcellular localization image for KLHL15 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IEA --
genes like me logo Genes that share ontologies with KLHL15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL15 Gene

Pathways for KLHL15 Gene

SuperPathways for KLHL15 Gene

No Data Available

UniProtKB/Swiss-Prot Q96M94-KLH15_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for KLHL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL15: view

No data available for Pathways by source for KLHL15 Gene

Transcripts for KLHL15 Gene

mRNA/cDNA for KLHL15 Gene

Unigene Clusters for KLHL15 Gene

Kelch-like family member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL15 Gene

No ASD Table

Relevant External Links for KLHL15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL15 Gene

mRNA expression in normal human tissues for KLHL15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL15 Gene

SOURCE GeneReport for Unigene cluster for KLHL15 Gene Hs.495854

genes like me logo Genes that share expressions with KLHL15: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHL15 Gene

Orthologs for KLHL15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL15 35
  • 99.72 (n)
  • 99.83 (a)
KLHL15 36
  • 100 (a)
(Bos Taurus)
Mammalia KLHL15 35
  • 93.43 (n)
  • 98.51 (a)
KLHL15 36
  • 99 (a)
(Canis familiaris)
Mammalia KLHL15 35
  • 93.6 (n)
  • 99.01 (a)
KLHL15 36
  • 99 (a)
(Mus musculus)
Mammalia Klhl15 35
  • 90.84 (n)
  • 99.34 (a)
Klhl15 16
Klhl15 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
-- 36
  • 95 (a)
-- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL15 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Klhl15 35
  • 91.28 (n)
  • 99.34 (a)
(Gallus gallus)
Aves KLHL15 35
  • 84.44 (n)
  • 94.21 (a)
KLHL15 36
  • 94 (a)
(Anolis carolinensis)
Reptilia KLHL15 36
  • 93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19515 35
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl15 35
  • 78.42 (n)
  • 90.56 (a)
Str.20207 35
(Danio rerio)
Actinopterygii Dr.28665 35
klhl15 35
  • 72.74 (n)
  • 85.26 (a)
klhl15 36
  • 79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
-- 36
  • 30 (a)
CSA.449 36
  • 27 (a)
Species with no ortholog for KLHL15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL15 Gene

Gene Tree for KLHL15 (if available)
Gene Tree for KLHL15 (if available)

Paralogs for KLHL15 Gene

Selected SIMAP similar genes for KLHL15 Gene using alignment to 2 proteins: Pseudogenes for KLHL15 Gene

genes like me logo Genes that share paralogs with KLHL15: view

Variants for KLHL15 Gene

Sequence variations from dbSNP and Humsavar for KLHL15 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3073993 -- 23,985,942(+) TTTTT(-/TTT)AAATG utr-variant-3-prime
rs3813165 -- 23,986,969(+) CAGGG(C/T)AACGT utr-variant-3-prime
rs3829712 -- 23,987,327(+) TAGGT(C/T)GTATG utr-variant-3-prime
rs3922951 -- 23,993,208(+) GCTT(C/G)AGGCT intron-variant
rs4428823 -- 24,019,628(-) TCTTA(C/T)ACTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL15 Gene

Variant ID Type Subtype PubMed ID
esv2740010 CNV Deletion 23290073
esv2660439 CNV Deletion 23128226
nsv524256 CNV Gain 19592680
esv22476 CNV Loss 19812545

Relevant External Links for KLHL15 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL15 Gene

Disorders for KLHL15 Gene

No disorders were found for KLHL15 Gene.

No data available for UniProtKB/Swiss-Prot for KLHL15 Gene

Publications for KLHL15 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Identification and characterization of a novel kelch-like gene KLHL15 in silico. (PMID: 15870933) Yoshida K. (Oncol. Rep. 2005) 3 23
  4. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. (PMID: 14528312) Furukawa M. … Xiong Y. (Nat. Cell Biol. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KLHL15 Gene

Sources for KLHL15 Gene

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