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KLHL15 Gene

protein-coding   GIFtS: 50
GCID: GC0XM023911

Kelch-Like Family Member 15

(Previous name: kelch-like 15 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 151 2     Kelch-Like 152
Kelch-Like 15 (Drosophila)1     Kelch-Like Protein 152
HEL-S-3052     KIAA16773
Epididymis Secretory Protein Li 3052     

External Ids:    HGNC: 293471   Entrez Gene: 803112   Ensembl: ENSG000001740107   UniProtKB: Q96M943   

Export aliases for KLHL15 gene to outside databases

Previous GC identifers: GC0XM023364 GC0XM023761 GC0XM021746


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLHL15 Gene:
This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of
an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat
motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. (provided by
RefSeq, Apr 2009)

GeneCards Summary for KLHL15 Gene:
KLHL15 (kelch-like family member 15) is a protein-coding gene. An important paralog of this gene is KLHL42.

UniProtKB/Swiss-Prot: KLH15_HUMAN, Q96M94
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_167197.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL15 gene promoter:
         AhR   STAT1   Sox5   STAT4   STAT1beta   STAT5A   STAT1alpha   Evi-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL15 promoter sequence
   Search Chromatin IP Primers for KLHL15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.1-p21   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.1-p21

KLHL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL15 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM023911:  view genomic region     (about GC identifiers)

Start:
24,001,833 bp from pter      End:
24,045,303 bp from pter
Size:
43,471 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLH15_HUMAN, Q96M94 (See protein sequence)
Recommended Name: Kelch-like protein 15  
Size: 604 amino acids; 69775 Da
Subunit: Interacts with CUL3
Secondary accessions: Q32MN3 Q8NDA3 Q96BM6 Q9C0I6

Explore the universe of human proteins at neXtProt for KLHL15: NX_Q96M94

Explore proteomics data for KLHL15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLHL15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_085127.2  
    ENSEMBL proteins: 
     ENSP00000332791  

    KLHL15 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KLHL15

     
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    antibodies-online antibodies for KLHL15 (15 products) 

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    antibodies-online kits for KLHL15 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR013069 BTB_POZ
     IPR011705 BACK

    Graphical View of Domain Structure for InterPro Entry Q96M94

    ProtoNet protein and cluster: Q96M94

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH15_HUMAN, Q96M94
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 Kelch repeats


    Find genes that share domains with KLHL15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH15_HUMAN, Q96M94
    Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the
    ubiquitination and subsequent proteasomal degradation of target proteins

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KLHL15           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL15:
     Increased cell death HMECs cel 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KLHL15

    miRNA
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    miRTarBase miRNAs that target KLHL15:
    hsa-mir-30b-5p (MIRT046145), hsa-mir-365a-3p (MIRT044038), hsa-mir-425-3p (MIRT042419), hsa-mir-192-5p (MIRT026433), hsa-mir-21-5p (MIRT030865), hsa-mir-20a-5p (MIRT050580), hsa-mir-532-3p (MIRT037925), hsa-mir-378a-3p (MIRT043943), hsa-mir-181a-5p (MIRT047333), hsa-mir-500a-3p (MIRT041147), hsa-mir-96-5p (MIRT048729), hsa-mir-423-3p (MIRT042560), hsa-mir-100-5p (MIRT048469), hsa-mir-744-5p (MIRT037424), hsa-mir-30c-5p (MIRT047915), hsa-mir-92a-3p (MIRT049095)

    Block miRNA regulation of human, mouse, rat KLHL15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL15 (see all 153):
    hsa-miR-193a-3p hsa-miR-640 hsa-miR-520f hsa-miR-106a hsa-miR-508-5p hsa-miR-130b hsa-miR-92b hsa-miR-520b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: KLH15_HUMAN, Q96M94
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL15
    Interactions:

        Search GeneGlobe Interaction Network for KLHL15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for KLHL15 (Q96M943 ENSP000003327914) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    DVL2O146413I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with KLHL15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL15 (KLH15)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLHL15 gene: 
    NM_030624.2  

    Unigene Cluster for KLHL15:

    Kelch-like family member 15
    Hs.495854  [show with all ESTs]
    Unigene Representative Sequence: NM_030624
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328046(uc004dba.4)
    miRNA
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    Block miRNA regulation of human, mouse, rat KLHL15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL15 (see all 153):
    hsa-miR-193a-3p hsa-miR-640 hsa-miR-520f hsa-miR-106a hsa-miR-508-5p hsa-miR-130b hsa-miR-92b hsa-miR-520b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL15
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    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL15
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL15
      QuantiTect SYBR Green Assays in human, mouse, rat KLHL15
      QuantiFast Probe-based Assays in human, mouse, rat KLHL15

    Additional mRNA sequence: 

    AB051464.1 AK057298.1 AL834313.1 BC015415.1 BC109058.2 BC109059.2 

    3 DOTS entries:

    DT.410075  DT.101986119  DT.95108112 

    Selected AceView cDNA sequences (see all 60):

    AA918190 CB216931 AW151819 AK057298 AB051464 AI167401 AW627710 AA031900 
    AI915056 BQ940126 AW015035 AW207538 BX114718 BM720658 BF055476 AL834313 
    AA489351 BC015415 AA127514 AA031773 CD558147 AI650934 BE047834 BM549521 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATGCTAT
    KLHL15 Expression
    About this image


    KLHL15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    KLHL15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495854
        Custom PCR Arrays for KLHL15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL15 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl151 , 5 kelch-like 15 (Drosophila)5
    kelch-like 151
    90.84(n)1
    99.34(a)1
      X (41.53 cM)5
    2369041  NM_001039061.11  NP_001034150.11 
     942345995 
    chicken
    (Gallus gallus)
    Aves KLHL151 kelch-like 15 (Drosophila) 84.44(n)
    94.21(a)
      418598  NM_001143670.1  NP_001137142.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL156
    kelch-like family member 15
    93(a)
    1 ↔ 1
    3(125745300-125764182)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195152 Xenopus laevis transcribed sequence with weak similarity more 81.47(n)    BQ386636.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.286652 Transcribed sequence with weak similarity to protein more 75.4(n)    57035122 


    ENSEMBL Gene Tree for KLHL15 (if available)
    TreeFam Gene Tree for KLHL15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL15 gene
    KLHL422  KLHL132  KLHL222  KLHL262  KLHL342  KLHL312  KBTBD132  KBTBD112  
    KLHL322  KLHL92  KLHL142  KLHDC7B2  KLHL362  KLHL332  KLHDC7A2  
    11 SIMAP similar genes for KLHL15 using alignment to 2 protein entries:     KLH15_HUMAN (see all proteins):
    BACH2    KBTBD3    KLHL32    DKFZp686L0695    KLHL9    BTBD3
    KLHL13    KLHL22    KLHL26    KLHL31    KLHL36

    Find genes that share paralogs with KLHL15           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KLHL15
    PGOHUM00000236339


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL15 (see all 720)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59259691,2
    C,F,A,H--23916201(+) AGAGGC/TTGGAA 1 -- ds500115Minor allele frequency- T:0.27NS EA NA 1983
    rs1424297651,2
    --23916369(+) GGAAAC/TCTAAA 1 -- ds50010--------
    rs1855351001,2
    --23916551(+) TCTGCA/GGCTGA 1 -- ds50010--------
    rs66297811,2
    C,H--23916834(+) ATTACC/TTGACA 1 -- ut31 ese32Minor allele frequency- T:0.01NS NA 180
    rs413114971,2
    C--23917193(+) TAATAC/TTGAAG 1 -- ut311Minor allele frequency- T:0.00CSA 1
    rs1907893761,2
    --23917472(+) GCCATA/GTAGCC 1 -- ut310--------
    rs1830194351,2
    --23917836(+) AAAGGC/TGCTGC 1 -- ut310--------
    rs1385455821,2
    --23918036(+) TTAAGA/GAAAGG 1 -- ut310--------
    rs1411402071,2
    C--23918101(+) AGAGAA/CCAAAT 1 -- ut310--------
    rs1508108941,2
    --23918502(+) TAAAGC/TTCAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KLHL15 (24001833 - 24045303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLHL15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660439CNV Deletion23128226
    esv2740010CNV Deletion23290073
    esv22476CNV Loss19812545
    nsv524256CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): KLHL15

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL15 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with KLHL15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. (PubMed id 14528312)1, 2 Furukawa M.... Xiong Y. (Nat. Cell Biol. 2003)
    5. Identification and characterization of a novel kelch-like gene KLHL15 in silico. (PubMed id 15870933)1, 9 Yoshida K. (Oncol. Rep. 2005)
    6. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    7. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    8. Selective proteasomal degradation of the B'I^ subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. (PubMed id 23135275)1 Oberg E.A....Strack S. (J. Biol. Chem. 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80311 HGNC: 29347 AceView: KLHL15 Ensembl:ENSG00000174010 euGenes: HUgn80311
    ECgene: KLHL15 H-InvDB: KLHL15

    (According to HUGE)
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    HUGE: KIAA1677

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLHL15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL15 gene:
    Search GeneIP for patents involving KLHL15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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