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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL15 Gene

protein-coding   GIFtS: 48
GCID: GC0XM023911

Kelch-Like Family Member 15

(Previous name: kelch-like 15 (Drosophila))
  Search for KLHL15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 151 2
Kelch-Like 15 (Drosophila)1
Kelch-Like 152
Kelch-Like Protein 152
KIAA16773

External Ids:    HGNC: 293471   Entrez Gene: 803112   Ensembl: ENSG000001740107   UniProtKB: Q96M943   

Export aliases for KLHL15 gene to outside databases

Previous GC identifers: GC0XM023364 GC0XM023761 GC0XM021746


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLHL15 Gene:
This gene encodes a member of the kelch-like family of proteins that share a common domain structure consisting of
an N-terminal broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger domain and C-terminal kelch repeat
motifs. The encoded protein may be involved in protein ubiquitination and cytoskeletal organization. (provided by
RefSeq, Apr 2009)

GeneCards Summary for KLHL15 Gene: 
KLHL15 (kelch-like family member 15) is a protein-coding gene. An important paralog of this gene is KLHL42.

UniProtKB/Swiss-Prot: KLH15_HUMAN, Q96M94
Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the
ubiquitination and subsequent proteasomal degradation of target proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL15 gene promoter:
         AhR   STAT1   Sox5   STAT4   STAT1beta   STAT5A   STAT1alpha   Evi-1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL15 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHL15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.1-p21   Ensembl cytogenetic band:  Xp22.11   HGNC cytogenetic band: Xp22.1-p21

KLHL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL15 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM023911:  view genomic region     (about GC identifiers)

Start:
24,001,833 bp from pter      End:
24,045,303 bp from pter
Size:
43,471 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLH15_HUMAN, Q96M94 (See protein sequence)
Recommended Name: Kelch-like protein 15  
Size: 604 amino acids; 69775 Da
Subunit: Interacts with CUL3
Secondary accessions: Q32MN3 Q8NDA3 Q96BM6 Q9C0I6

Explore the universe of human proteins at neXtProt for KLHL15: NX_Q96M94

Explore proteomics data for KLHL15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96M94

  • KLHL15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL15 Protein Expression
    REFSEQ proteins: NP_085127.2  
    ENSEMBL proteins: 
     ENSP00000332791  

    Human Recombinant Protein Products for KLHL15: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    5/7 InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin
     IPR013069 BTB_POZ
     IPR011705 BACK

    Graphical View of Domain Structure for InterPro Entry Q96M94

    ProtoNet protein and cluster: Q96M94

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH15_HUMAN, Q96M94
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 Kelch repeats


    KLHL15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH15_HUMAN, Q96M94
    Function: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the
    ubiquitination and subsequent proteasomal degradation of target proteins

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KLHL15 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL15:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL15

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: KLH15_HUMAN, Q96M94
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for KLHL15 (Q96M943 ENSP000003327914) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    DVL2O146413I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    KLHL15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL15 (KLH15)

    Search CenterWatch for drugs/clinical trials and news about KLHL15 / KLH15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL15 gene: 
    NM_030624.2  

    Unigene Cluster for KLHL15:

    Kelch-like family member 15
    Hs.495854  [show with all ESTs]
    Unigene Representative Sequence: NM_030624
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000328046(uc004dba.4)
    miRNA
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    hsa-miR-193a-3p hsa-miR-640 hsa-miR-520f hsa-miR-106a hsa-miR-508-5p hsa-miR-130b hsa-miR-92b hsa-miR-520b
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL15

    Additional mRNA sequence: 

    AB051464.1 AK057298.1 AL834313.1 BC015415.1 BC109058.2 BC109059.2 

    3 DOTS entries:

    DT.410075  DT.101986119  DT.95108112 

    24/60 AceView cDNA sequences (see all 60):

    AW151819 AW015035 BF055476 AW627710 AA918190 AA031900 AK057298 AB051464 
    AL834313 BQ940126 BX114718 BC015415 BM720658 CB216931 AI915056 AW207538 
    AA489351 AI167401 BE047834 AI650934 BF980594 AA679710 AL048237 BX493272 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL15 expression in normal human tissues (normalized intensities)      KLHL15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATGCTAT
    KLHL15 Expression
    About this image


    KLHL15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retina   
     
     Ovary (Reproductive System)
             oocyte   

    See KLHL15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL15

    SOURCE GeneReport for Unigene cluster: Hs.495854
        SABiosciences Custom PCR Arrays for KLHL15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL15 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl151 , 5 kelch-like 15 (Drosophila)1, 5 90.84(n)1
    99.34(a)1
      X (41.53 cM)5
    2369041  NM_001039061.11  NP_001034150.11 
     942345995 
    chicken
    (Gallus gallus)
    Aves KLHL151 kelch-like 15 (Drosophila) 84.44(n)
    94.21(a)
      418598  NM_001143670.1  NP_001137142.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL156
    Uncharacterized protein
    93(a)
    1 ↔ 1
    3(125745300-125764182)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195152 Xenopus laevis transcribed sequence with weak similarity more 81.47(n)    BQ386636.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.286652 Transcribed sequence with weak similarity to protein more 75.4(n)    57035122 


    ENSEMBL Gene Tree for KLHL15 (if available)
    TreeFam Gene Tree for KLHL15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL15 gene
    KLHL422  KLHL132  KLHL222  KLHL262  KLHL342  KLHL312  KBTBD132  KBTBD112  
    KLHL322  KLHL92  KLHL142  KLHDC7B2  KLHL362  KLHL332  KLHDC7A2  
    11 SIMAP similar genes for KLHL15 using alignment to 2 protein entries:     KLH15_HUMAN (see all proteins):
    BACH2    KBTBD3    KLHL32    DKFZp686L0695    KLHL9    BTBD3
    KLHL13    KLHL22    KLHL26    KLHL31    KLHL36

    KLHL15 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KLHL15
    PGOHUM00000236339


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/720 SNPs in KLHL15 are shown (see all 720)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59259691,2
    C,F,A,H--23916201(+) AGAGGC/TTGGAA 1 -- ds500115Minor allele frequency- T:0.27NS EA NA 1983
    rs1424297651,2
    --23916369(+) GGAAAC/TCTAAA 1 -- ds50010--------
    rs1855351001,2
    --23916551(+) TCTGCA/GGCTGA 1 -- ds50010--------
    rs66297811,2
    C,H--23916834(+) ATTACC/TTGACA 1 -- ut31 ese32Minor allele frequency- T:0.01NS NA 180
    rs413114971,2
    C--23917193(+) TAATAC/TTGAAG 1 -- ut311Minor allele frequency- T:0.00CSA 1
    rs1907893761,2
    --23917472(+) GCCATA/GTAGCC 1 -- ut310--------
    rs1830194351,2
    --23917836(+) AAAGGC/TGCTGC 1 -- ut310--------
    rs1385455821,2
    --23918036(+) TTAAGA/GAAAGG 1 -- ut310--------
    rs1411402071,2
    C--23918101(+) AGAGAA/CCAAAT 1 -- ut310--------
    rs1508108941,2
    --23918502(+) TAAAGC/TTCAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KLHL15 (24001833 - 24045303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLHL15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660439CNV Deletion23128226
    esv2740010CNV Deletion23290073
    esv22476CNV Loss19812545
    nsv524256CNV Gain19592680


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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL15 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with KLHL15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. (PubMed id 14528312)1, 2 Furukawa M.... Xiong Y. (2003)
    5. Identification and characterization of a novel kelch-like gene KLHL15 in silico. (PubMed id 15870933)1, 9 Yoshida K. (2005)
    6. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    7. Selective proteasomal degradation of the B'b subunit o f protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. (PubMed id 23135275)1 Oberg E.A....Strack S. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80311 HGNC: 29347 AceView: KLHL15 Ensembl:ENSG00000174010 euGenes: HUgn80311
    ECgene: KLHL15 H-InvDB: KLHL15

    (According to HUGE)
    About This Section
    HUGE: KIAA1677

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL15 gene:
    Search GeneIP for patents involving KLHL15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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