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KLHL14 Gene

protein-coding   GIFtS: 49
GCID: GC18M030252

Kelch-Like Family Member 14

(Previous name: kelch-like 14 (Drosophila))
  Search for KLHL14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 141 2     Kelch-Like 14 (Drosophila)1
printor1 2     Kelch-Like 142
Protein Interactor Of Torsin-1A2 3     Kelch-Like Protein 142
Protein Interactor Of TorsinA2 3     Printor3
KIAA13843 5     PRINTOR5

External Ids:    HGNC: 292661   Entrez Gene: 575652   Ensembl: ENSG000001977057   OMIM: 6137725   UniProtKB: Q9P2G33   

Export aliases for KLHL14 gene to outside databases

Previous GC identifers: GC18M028505 GC18M028506 GC18M027110


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL14 Gene:
KLHL14 (kelch-like family member 14) is a protein-coding gene. An important paralog of this gene is KLHL42.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL14 gene promoter:
         Sp1   p53   Evi-1   MEF-2A   Pax-3   PPAR-gamma1   POU2F1   POU2F1a   aMEF-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL14 promoter sequence
   Search Chromatin IP Primers for KLHL14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q12.1   Ensembl cytogenetic band:  18q12.1   HGNC cytogenetic band: 18q12.1

KLHL14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL14 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M030252:  view genomic region     (about GC identifiers)

Start:
30,252,634 bp from pter      End:
30,353,025 bp from pter
Size:
100,392 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLH14_HUMAN, Q9P2G3 (See protein sequence)
Recommended Name: Kelch-like protein 14  
Size: 628 amino acids; 70714 Da
Subunit: Interacts with TOR1A, preferentially with the ATP-free form
Sequence caution: Sequence=BAA92622.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAG58061.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NNW1 B4DHA0 Q8WU41
Alternative splicing: 2 isoforms:  Q9P2G3-1   Q9P2G3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLHL14: NX_Q9P2G3

Explore proteomics data for KLHL14 at MOPED


See KLHL14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_065856.1  
ENSEMBL proteins: 
 ENSP00000352314   ENSP00000350808   ENSP00000463803  

KLHL14 Human Recombinant Protein Products:

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LSBio Antibodies in human, mouse, rat for KLHL14

KLHL14 Assay Products:

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Search eBioscience for ELISAs for KLHL14 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
BTBD: BTB/POZ domain containing
KLHL: Kelch-like

Selected InterPro protein domains (see all 7):
 IPR006652 Kelch_1
 IPR011333 BTB/POZ_fold
 IPR017096 Kelch-like_gigaxonin-typ
 IPR013069 BTB_POZ
 IPR011705 BACK

Graphical View of Domain Structure for InterPro Entry Q9P2G3

ProtoNet protein and cluster: Q9P2G3

2 Blocks protein domains:
IPB000210 BTB/POZ domain
IPB011705 BTB/Kelch-associated


UniProtKB/Swiss-Prot: KLH14_HUMAN, Q9P2G3
Similarity: Contains 1 BACK (BTB/Kelch associated) domain
Similarity: Contains 1 BTB (POZ) domain
Similarity: Contains 6 Kelch repeats


Find genes that share domains with KLHL14           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with KLHL14           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for KLHL14:
 Increased HPV18 LCR reporter a 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL14
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLHL14

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL14
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL14

miRNA
Products:
    
miRTarBase miRNAs that target KLHL14:
hsa-mir-124-3p (MIRT023024)

Block miRNA regulation of human, mouse, rat KLHL14 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KLHL14 (see all 39):
hsa-miR-142-5p hsa-miR-579 hsa-miR-3164 hsa-miR-562 hsa-miR-429 hsa-miR-330-5p hsa-miR-134 hsa-miR-25
SwitchGear 3'UTR luciferase reporter plasmidKLHL14 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for KLHL14
Predesigned siRNA for gene silencing in human, mouse, rat KLHL14

Gene Editing
Products:
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OriGene ORF clones in mouse, rat for KLHL14
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GenScript: all cDNA clones in your preferred vector: KLHL14 (NM_020805)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL14
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL14

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL14


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
KLH14_HUMAN, Q9P2G3: Cytoplasm, cytosol. Endoplasmic reticulum membrane. Note=Colocalizes with TOR1A at the
endoplasmic reticulum level
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol5
endoplasmic reticulum5
nucleus2
cytoskeleton1
mitochondrion1
peroxisome1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005783endoplasmic reticulum IDA19535332
GO:0005789endoplasmic reticulum membrane IEA--
GO:0005829cytosol IEA--
GO:0043005neuron projection IEA--
GO:0043025neuronal cell body IEA--

Find genes that share ontologies with KLHL14           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL14
Interactions:

    Search GeneGlobe Interaction Network for KLHL14

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for KLHL14 (ENSP000003523144) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TGFBR1ENSP000003641334STRING: ENSP00000364133
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for KLHL14 (KLH14)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for KLHL14 gene: 
NM_020805.1  

Unigene Cluster for KLHL14:

Kelch-like family member 14
Hs.446164  [show with all ESTs]
Unigene Representative Sequence: AB037805
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000359358(uc002kxm.1) ENST00000358095 ENST00000583263
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat KLHL14 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KLHL14 (see all 39):
hsa-miR-142-5p hsa-miR-579 hsa-miR-3164 hsa-miR-562 hsa-miR-429 hsa-miR-330-5p hsa-miR-134 hsa-miR-25
SwitchGear 3'UTR luciferase reporter plasmidKLHL14 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for KLHL14
Predesigned siRNA for gene silencing in human, mouse, rat KLHL14
Clone
Products:
     
OriGene clones in human, mouse for KLHL14 (see all 6)
OriGene ORF clones in mouse, rat for KLHL14
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: KLHL14 (NM_020805)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL14
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL14
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for KLHL14
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL14
  QuantiTect SYBR Green Assays in human, mouse, rat KLHL14
  QuantiFast Probe-based Assays in human, mouse, rat KLHL14

Additional mRNA sequence: 

AB037805.1 AK294996.1 BC021267.2 

3 DOTS entries:

DT.455130  DT.97822013  DT.100688897 

Selected AceView cDNA sequences (see all 43):

BM473521 AA843853 BI915048 AB037805 AI539017 AW572056 BM683505 BX386279 
AA262223 CR604173 AI741736 AW473777 AI091311 BC021267 AW419074 AW504050 
AW591052 AA465329 BM718460 BG423085 AA761274 BI915130 AI051108 BX348902 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KLHL14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATAGAATGA
KLHL14 Expression
About this image


KLHL14 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
         Epiblast Cells Epiblast
         Epiblast-like cells
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Mature B-Cells Peripheral Blood
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Spinal Ventral Columns
 
 Testis (Reproductive System)
         Sertoli cells Seminiferous Tubules
KLHL14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KLHL14 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.446164
    Custom PCR Arrays for KLHL14
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for KLHL14
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL14
QuantiTect SYBR Green Assays in human, mouse, rat KLHL14
QuantiFast Probe-based Assays in human, mouse, rat KLHL14
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL14

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for KLHL14 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Klhl141 , 5 kelch-like 14 (Drosophila)5
kelch-like 141
91.93(n)1
98.09(a)1
  18 (11.96 cM)5
2252661  NM_001081403.11  NP_001074872.11 
 215503795 
chicken
(Gallus gallus)
Aves KLHL141 kelch-like 14 (Drosophila) 88.42(n)
96.75(a)
  421100  NM_001012866.1  NP_001012884.1 
lizard
(Anolis carolinensis)
Reptilia KLHL146
kelch-like family member 14
98(a)
1 ↔ 1
GL343207.1(3145987-3189190)
tropical clawed frog
(Xenopus tropicalis)
Amphibia klhl141 kelch-like family member 14 81.42(n)
95.57(a)
  100493162  XM_002934117.2  XP_002934163.1 
zebrafish
(Danio rerio)
Actinopterygii klhl141 kelch-like family member 14 81.41(n)
91.58(a)
  794722  XM_001334693.4  XP_001334729.4 


ENSEMBL Gene Tree for KLHL14 (if available)
TreeFam Gene Tree for KLHL14 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KLHL14 gene
KLHL422  KLHL132  KLHL222  KLHL262  KLHL342  KLHL312  KBTBD132  KBTBD112  
KLHL322  KLHL92  KLHL152  KLHL362  KLHDC7B2  KLHL332  KLHDC7A2  
18 SIMAP similar genes for KLHL14 using alignment to 2 protein entries:     KLH14_HUMAN (see all proteins):
KLHL24    ZBTB7C    BACH2    KLHL28    ZNF131    DKFZp686L0695
HIC1    ZBTB4    KLHL36    FLJ00127    KLHL32    BCL6B
KLHL13    ZBTB38    KLHL9    KLHL31    KLHL5    DKFZp761P1717

Find genes that share paralogs with KLHL14           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KLHL14 (see all 1936)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 18 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs758678761,2
F--30252158(+) CAAGCC/TTTAGT 1 -- ds50012Minor allele frequency- T:0.01WA NA 238
rs1491888031,2
--30252279(+) TGTGTA/GACTCA 1 -- ds50010--------
rs1857072361,2
--30252295(+) TCTTTA/GAAAAG 1 -- ds50010--------
rs1434174391,2
--30252334(+) CTTCTA/TATAAT 1 -- ds50010--------
rs1483709811,2
C--30252370(+) CTCAGA/GTAAGT 1 -- ds50010--------
rs18460131,2
C,F,A,H--30252515(+) GCCAAA/GTAACA 1 -- ds500118Minor allele frequency- G:0.19NS EA NA WA 2336
rs1415671161,2
--30252987(+) ACTTTC/TCTTTC 1 -- ut310--------
rs1999736391,2
C--30253010(+) TGTTTC/TAAGGA 1 -- ut310--------
rs717954371,2
C--30253011(+) TTTTA-/CAGGAA 1 -- ut310--------
rs2000722751,2
C--30253011(+) GTTTTA/CAGGAA 1 -- ut310--------

HapMap Linkage Disequilibrium report for KLHL14 (30252634 - 30353025 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for KLHL14:    About this table    
Variant IDTypeSubtypePubMed ID
esv998622CNV Deletion20482838
nsv909526CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing KLHL14
DNA2.0 Custom Variant and Variant Library Synthesis for KLHL14

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613772    OMIM disorders: --


Find genes that share disorders with KLHL14           About GenesLikeMe

Genetic Association Database (GAD): KLHL14
Human Genome Epidemiology (HuGE) Navigator: KLHL14 (1 document)

Export disorders for KLHL14 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KLHL14 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with KLHL14)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis. (PubMed id 19535332)1, 2, 3 Giles L.M.... Chin L.S. (J. Biol. Chem. 2009)
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  4. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
  5. Regulation of Torsin ATPases by LAP1 and LULL1. (PubMed id 23569223)1 Zhao C....Schlieker C. (Proc. Natl. Acad. Sci. U.S.A. 2013)
  6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
  7. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
  8. DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (Nature 2005)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57565 HGNC: 29266 AceView: KLHL14 Ensembl:ENSG00000197705 euGenes: HUgn57565
ECgene: KLHL14 H-InvDB: KLHL14

(According to HUGE)
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HUGE: KIAA1384

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KLHL14 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KLHL14 gene:
Search GeneIP for patents involving KLHL14

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLHL14  
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 Block miRNA regulation of human, mouse, rat KLHL14 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLHL14
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL14 Predesigned siRNA for gene silencing in human, mouse, rat KLHL14
 QuantiFast Probe-based Assays in human, mouse, rat KLHL14 QuantiTect SYBR Green Assays in human, mouse, rat KLHL14
 Custom PCR Arrays for KLHL14 Search Chromatin IP Primers for KLHL14
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL14  Search GeneGlobe Interaction Network for KLHL14
 Regulatory tfbs in KLHL14 promoter
 GenScript Custom Purified and Recombinant Proteins Services for KLHL14 GenScript cDNA clones with any tag delivered in your preferred vector for KLHL14
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 Search Tocris compounds for KLHL14 (KLH14)
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 Novus Tissue Slides
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 Proteins for KLHL14
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 Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL14
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL14
 SwitchGear 3'UTR luciferase reporter plasmids for KLHL14
 SwitchGear Promoter luciferase reporter plasmids for KLHL14
 Search ThermoFisher Antibodies for KLHL14
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL14
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL14
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLHL14
 LSBio Antibodies in human, mouse, rat for KLHL14
Customized transgenic rodents for:
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 Browse compounds at ApexBio
 Search Addgene for plasmids for KLHL14
  Search eBioscience for proteins for KLHL14
  Search eBioscience for elisas for KLHL14
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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