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Aliases for KLHL13 Gene

Aliases for KLHL13 Gene

  • Kelch-Like Family Member 13 2 3
  • BKLHD2 3 4
  • BTB And Kelch Domain Containing 2, KIAA1309 2
  • BTB And Kelch Domain-Containing Protein 2 4
  • BTB And Kelch Domain Containing 2 3
  • Kelch-Like 13 (Drosophila) 2
  • Kelch-Like 13 3
  • KIAA1309 4

External Ids for KLHL13 Gene

Previous HGNC Symbols for KLHL13 Gene

  • BKLHD2
  • KIAA1309

Previous GeneCards Identifiers for KLHL13 Gene

  • GC0XM115786
  • GC0XM116813
  • GC0XM116915
  • GC0XM117031
  • GC0XM106526

Summaries for KLHL13 Gene

Entrez Gene Summary for KLHL13 Gene

  • This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for KLHL13 Gene

KLHL13 (Kelch-Like Family Member 13) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is KLHL36.

UniProtKB/Swiss-Prot for KLHL13 Gene

  • Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL13 Gene

Genomics for KLHL13 Gene

Regulatory Elements for KLHL13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL13 Gene

Chromosome:
X
Start:
117,897,813 bp from pter
End:
118,117,340 bp from pter
Size:
219,528 bases
Orientation:
Minus strand

Genomic View for KLHL13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL13 Gene

Proteins for KLHL13 Gene

  • Protein details for KLHL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2N7-KLH13_HUMAN
    Recommended name:
    Kelch-like protein 13
    Protein Accession:
    Q9P2N7
    Secondary Accessions:
    • B3KV78
    • B3KWM7
    • B7Z3S9
    • B7Z5P2
    • B7Z802
    • D3DWH6
    • Q6P2E3
    • Q96QI7
    • Q9UDN9

    Protein attributes for KLHL13 Gene

    Size:
    655 amino acids
    Molecular mass:
    73868 Da
    Quaternary structure:
    • Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB.
    SequenceCaution:
    • Sequence=BAA92547.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC41335.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHL13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHL13 Gene

Proteomics data for KLHL13 Gene at MOPED

Post-translational modifications for KLHL13 Gene

  • Ubiquitination at Lys 213, Lys 221, Lys 277, Lys 280, and Lys 370
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for KLHL13 Gene

Domains & Families for KLHL13 Gene

Gene Families for KLHL13 Gene

Suggested Antigen Peptide Sequences for KLHL13 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2N7

UniProtKB/Swiss-Prot:

KLH13_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 6 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL13: view

Function for KLHL13 Gene

Molecular function for KLHL13 Gene

UniProtKB/Swiss-Prot Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Gene Ontology (GO) - Molecular Function for KLHL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 17543862
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL13: view

Phenotypes for KLHL13 Gene

genes like me logo Genes that share phenotypes with KLHL13: view

Animal Model Products

miRNA for KLHL13 Gene

miRTarBase miRNAs that target KLHL13

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL13 Gene

Localization for KLHL13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL13 Gene COMPARTMENTS Subcellular localization image for KLHL13 gene
Compartment Confidence
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for KLHL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030496 midbody IBA --
GO:0031463 Cul3-RING ubiquitin ligase complex IDA 17543862
genes like me logo Genes that share ontologies with KLHL13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL13 Gene

Pathways & Interactions for KLHL13 Gene

genes like me logo Genes that share pathways with KLHL13: view

Pathways by source for KLHL13 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9P2N7-KLH13_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for KLHL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 17543862
GO:0007067 mitotic nuclear division IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL13: view

No data available for SIGNOR curated interactions for KLHL13 Gene

Drugs & Compounds for KLHL13 Gene

No Compound Related Data Available

Transcripts for KLHL13 Gene

Unigene Clusters for KLHL13 Gene

Kelch-like family member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL13 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
SP1: - -
SP2:
SP3: - - - -
SP4: -
SP5:

Relevant External Links for KLHL13 Gene

GeneLoc Exon Structure for
KLHL13
ECgene alternative splicing isoforms for
KLHL13

Expression for KLHL13 Gene

mRNA expression in normal human tissues for KLHL13 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL13 Gene

This gene is overexpressed in Uterus (x4.3).

Protein differential expression in normal tissues from HIPED for KLHL13 Gene

This gene is overexpressed in Plasma (55.1) and Gallbladder (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL13 Gene



SOURCE GeneReport for Unigene cluster for KLHL13 Gene Hs.348262

genes like me logo Genes that share expression patterns with KLHL13: view

Protein tissue co-expression partners for KLHL13 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL13 Gene

Orthologs for KLHL13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHL13 35
  • 95.01 (n)
  • 99.69 (a)
KLHL13 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL13 35
  • 94.53 (n)
  • 99.68 (a)
KLHL13 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl13 35
  • 91.04 (n)
  • 95.33 (a)
Klhl13 16
Klhl13 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHL13 35
  • 94.74 (n)
  • 93.56 (a)
rat
(Rattus norvegicus)
Mammalia Klhl13 35
  • 91.03 (n)
  • 95.87 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
chicken
(Gallus gallus)
Aves KLHL13 36
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3560 35
zebrafish
(Danio rerio)
Actinopterygii klhl13 36
  • 91 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToMany
Species with no ortholog for KLHL13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL13 Gene

ENSEMBL:
Gene Tree for KLHL13 (if available)
TreeFam:
Gene Tree for KLHL13 (if available)

Paralogs for KLHL13 Gene

Pseudogenes.org Pseudogenes for KLHL13 Gene

genes like me logo Genes that share paralogs with KLHL13: view

Variants for KLHL13 Gene

Sequence variations from dbSNP and Humsavar for KLHL13 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs725716 -- 117,970,416(+) TCAGA(A/T)TTGAA intron-variant
rs765236 -- 117,989,472(-) GGAGG(A/G)GAGGT intron-variant
rs877902 -- 117,922,856(+) TAACC(A/T)CTGTT intron-variant
rs879370 -- 117,923,522(-) TTGTT(C/T)TTTAG intron-variant
rs1985828 -- 118,106,085(+) ttttg(G/T)atttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL13 Gene

Variant ID Type Subtype PubMed ID
esv271191 CNV Insertion 20981092
nsv510855 CNV Loss 20534489
nsv526997 CNV Gain 19592680
esv270236 CNV Insertion 20981092

Variation tolerance for KLHL13 Gene

Residual Variation Intolerance Score: 15.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL13 Gene

HapMap Linkage Disequilibrium report
KLHL13
Human Gene Mutation Database (HGMD)
KLHL13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL13 Gene

Disorders for KLHL13 Gene

Relevant External Links for KLHL13

Genetic Association Database (GAD)
KLHL13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL13
genes like me logo Genes that share disorders with KLHL13: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL13 Gene

Publications for KLHL13 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 67
  5. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 67

Products for KLHL13 Gene

Sources for KLHL13 Gene

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