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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL13 Gene

protein-coding   GIFtS: 56
GCID: GC0XM117031

Kelch-Like Family Member 13

(Previous names: BTB and kelch domain containing 2, KIAA1309, kelch-like...)
(Previous symbols: BKLHD2, KIAA1309)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 131 2     BTB And Kelch Domain Containing 22
BKLHD21 2 3     Kelch-Like 132
KIAA13091 3     Kelch-Like Protein 132
BTB And Kelch Domain Containing 2, KIAA13091     BTB And Kelch Domain-Containing Protein 23
Kelch-Like 13 (Drosophila)1     

External Ids:    HGNC: 229311   Entrez Gene: 902932   Ensembl: ENSG000000030967   OMIM: 3006555   UniProtKB: Q9P2N73   

Export aliases for KLHL13 gene to outside databases

Previous GC identifers: GC0XM115786 GC0XM116813 GC0XM116915 GC0XM106526


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLHL13 Gene:
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing
superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and
other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for
proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Mar 2010)

GeneCards Summary for KLHL13 Gene: 
KLHL13 (kelch-like family member 13) is a protein-coding gene. Diseases associated with KLHL13 include prostate cancer, and prostatitis, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is KLHL42.

UniProtKB/Swiss-Prot: KLH13_HUMAN, Q9P2N7
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the
ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates
faithful mitotic progression and completion of cytokinesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL13 gene promoter:
         ISGF-3   Sox5   AML1a   Pax-6   Nkx2-2   HSF1 (long)   E4BP4   FOXC1   Cart-1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL13 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHL13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23-q24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq23-q24

KLHL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL13 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM117031:  view genomic region     (about GC identifiers)

Start:
117,031,776 bp from pter      End:
117,251,303 bp from pter
Size:
219,528 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLH13_HUMAN, Q9P2N7 (See protein sequence)
Recommended Name: Kelch-like protein 13  
Size: 655 amino acids; 73868 Da
Subunit: Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13
and RBX1. Interacts with AURKB
Sequence caution: Sequence=BAA92547.1; Type=Erroneous initiation; Sequence=CAC41335.1; Type=Erroneous initiation;
Secondary accessions: B3KV78 B3KWM7 B7Z3S9 B7Z5P2 B7Z802 D3DWH6 Q6P2E3 Q96QI7 Q9UDN9
Alternative splicing: 5 isoforms:  Q9P2N7-1   Q9P2N7-2   Q9P2N7-3   Q9P2N7-4   Q9P2N7-5   

Explore the universe of human proteins at neXtProt for KLHL13: NX_Q9P2N7

Explore proteomics data for KLHL13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2N7

  • KLHL13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL13 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001161771.1  NP_001161772.1  NP_001161773.1  NP_001161774.1  NP_001161775.1  NP_277030.2  

    ENSEMBL proteins: 
     ENSP00000360949   ENSP00000360943   ENSP00000360945   ENSP00000412640   ENSP00000419803  
     ENSP00000393807   ENSP00000444450   ENSP00000441029   ENSP00000443191   ENSP00000262820  
     ENSP00000440707  
    Reactome Protein details: Q9P2N7
    Human Recombinant Protein Products for KLHL13: 
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    Novus Biologicals KLHL13 Protein
    Novus Biologicals KLHL13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLHL13 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031463Cul3-RING ubiquitin ligase complex IDA17543862

    KLHL13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    5/7 InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q9P2N7

    ProtoNet protein and cluster: Q9P2N7

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH13_HUMAN, Q9P2N7
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH13_HUMAN, Q9P2N7
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for
    mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the
    ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates
    faithful mitotic progression and completion of cytokinesis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA17543862
    GO:0005515protein binding ----
         
    KLHL13 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KLHL13:
     Cell cycle / mitosis defect  Decreased nuclei size in G2M  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL13 
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    miRNA
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    hsa-miR-548p hsa-miR-938 hsa-miR-218 hsa-miR-646 hsa-miR-421 hsa-miR-4275 hsa-miR-129-3p hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmidKLHL13 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLHL13 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Aurora B signaling
    Aurora B signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KLHL13
        Aurora B signaling

    4        Reactome Pathways for KLHL13
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for KLHL13):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: KLH13_HUMAN, Q9P2N7
    Pathway: Protein modification; protein ubiquitination


    KLHL13 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/27 Interacting proteins for KLHL13 (Q9P2N73 ENSP000002628204) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZMYM6O957893, ENSP000003497084I2D: score=2 STRING: ENSP00000349708
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    ENSG00000271741O957893I2D: score=2 
    KLHL22Q53GT13, ENSP000003316824I2D: score=2 STRING: ENSP00000331682
    NUDCD3Q8IVD93, ENSP000003476264I2D: score=2 STRING: ENSP00000347626
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP17543862
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination IDA17543862

    KLHL13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL13 (KLH13)

    Search CenterWatch for drugs/clinical trials and news about KLHL13 / KLH13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL13 gene (6 alternative transcripts): 
    NM_001168299.1  NM_001168300.1  NM_001168301.1  NM_001168302.1  NM_001168303.1  NM_033495.3  

    Unigene Cluster for KLHL13:

    Kelch-like family member 13
    Hs.348262  [show with all ESTs]
    Unigene Representative Sequence: NM_033495
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371882 ENST00000371876(uc004eqk.3) ENST00000371878 ENST00000447671
    ENST00000469946 ENST00000453826 ENST00000541812(uc022cde.1) ENST00000540167(uc011mtq.2)
    ENST00000539496(uc011mtp.2) ENST00000262820(uc004eql.3 uc011mtn.2 uc011mto.2)
    ENST00000545703(uc004eqm.3)
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL13 (see all 9):
    hsa-miR-548p hsa-miR-938 hsa-miR-218 hsa-miR-646 hsa-miR-421 hsa-miR-4275 hsa-miR-129-3p hsa-miR-2113
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    Additional mRNA sequence: 

    AK001124.1 AK122724.1 AK125356.1 AK296324.1 AK297523.1 AK299257.1 AK302713.1 AK316509.1 
    AL591986.1 BC008729.2 BC064576.1 

    8 DOTS entries:

    DT.100666713  DT.100743166  DT.121307029  DT.110413  DT.121306993  DT.121307071  DT.92420770  DT.95184327 

    24/66 AceView cDNA sequences (see all 66):

    AI753736 AB037730 AA620455 NM_033495 BM699109 BC064576 BC008729 AW519303 
    N22179 BM669767 CR614631 AI800541 AA086182 BI549139 BM680509 BU607845 
    BU618521 AI755242 AK122724 AL591986 AI628964 BU620975 AI651535 BU941989 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL13    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                      -     -                                             
    SP2:                                                                                          
    SP3:                    -     -           -     -                                             
    SP4:                    -                                                                     
    SP5:                                                                                          


    ECgene alternative splicing isoforms for KLHL13

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL13 expression in normal human tissues (normalized intensities)      KLHL13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATCTTT
    KLHL13 Expression
    About this image


    KLHL13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See KLHL13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL13

    SOURCE GeneReport for Unigene cluster: Hs.348262
        SABiosciences Expression via Pathway-Focused PCR Arrays including KLHL13: 
              Prostate Cancer in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL13 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl131 , 5 kelch-like 13 (Drosophila)1, 5 91.04(n)1
    95.33(a)1
      X (17.22 cM)5
    674551  NM_026167.31  NP_080443.11 
     232192715 
    chicken
    (Gallus gallus)
    Aves KLHL96
    kelch-like protein 13
    89(a)
    1 → many
    4(3175772-3206798)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    89(a)
    1 → many
    GL343403.1(203973-276002)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.35602 Transcribed sequence with strong similarity to protein more 84.97(n)    AL847812.2 
    zebrafish
    (Danio rerio)
    Actinopterygii KLHL96
    si:rp71-68n21.96
    si:rp71-68n21.9
    91(a)
    55(a)
    1 ↔ many
    possible ortholog
    5(38943853-39040612)
    9(22198362-22208981)


    ENSEMBL Gene Tree for KLHL13 (if available)
    TreeFam Gene Tree for KLHL13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL13 gene
    KLHL422  KLHL222  KLHL262  KLHL342  KLHL312  KBTBD132  KBTBD112  KLHL322  
    KLHL92  KLHL142  KLHL152  KLHDC7B2  KLHL362  KLHL332  KLHDC7A2  
    18/28 SIMAP similar genes for KLHL13 using alignment to 3 protein entries:     KLH13_HUMAN (see all proteins) (see all similar genes):
    DKFZp686L0695    KLHL9    KLHL26    FLJ00127    KBTBD3    KLHL36
    KLHL31    BACH2    KLHL32    KLHL3    KIAA1900    KLHL14
    KLHL15    DKFZp761P1717    KLHL2    KLHL23    KLHL5    KLHL28

    KLHL13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KLHL13
    PGOHUM00000260454


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3310 SNPs in KLHL13 are shown (see all 3310)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0694234
    ----see VAR_0694232 T S mis40--------
    VAR_0647254
    ----see VAR_0647252 F I mis40--------
    rs626092131,2
    C,F--117026642(+) GATCAT/CAATAC 6 -- ds50011Minor allele frequency- C:0.00NA 2
    rs1491209191,2
    --117026725(+) TAAGGC/TAATTT 6 -- ds50010--------
    rs1923650771,2
    --117026779(+) TCAGGA/GAGACT 6 -- ds50010--------
    rs66454121,2
    C,F,A,H--117026791(+) AACTCA/GGAATT 6 -- ds500113Minor allele frequency- G:0.85NS EA NA 1402
    rs1478360731,2
    C--117026853(+) AAAGCC/TAGTTA 6 -- ds50010--------
    rs1837034781,2
    --117026916(+) ATAAGG/TTTAGA 6 -- ds50010--------
    rs626092141,2
    C,F--117027047(+) GTCAAG/ATCAGA 6 -- ds50011Minor allele frequency- A:0.00NA 2
    rs2013423131,2
    --117027452(+) TTTTT-/AAAAAA 6 -- ut310--------

    HapMap Linkage Disequilibrium report for KLHL13 (117031776 - 117251303 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLHL13:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv270236CNV Insertion20981092
    esv271191CNV Insertion20981092
    nsv510855CNV Loss20534489
    nsv526997CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): KLHL13
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL13
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300655    OMIM disorders: --

    2 diseases for KLHL13:    About MalaCards
    prostate cancer    prostatitis


    KLHL13 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLHL13

    Export disorders for KLHL13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL13 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with KLHL13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PubMed id 19995937)1, 2 Maerki S....Peter M. (2009)
    3. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PubMed id 19084217)1, 4 Benyamin B....Visscher P.M. (2009)
    4. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. (PubMed id 17543862)1, 2 Sumara I....Peter M. (2007)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    9. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    10. Diagnostic exome sequencing in persons with severe intellectual disability. (PubMed id 23033978)2 de Ligt J.... Vissers L.E. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90293 HGNC: 22931 AceView: KLHL13 Ensembl:ENSG00000003096 euGenes: HUgn90293
    ECgene: KLHL13 Kegg: 90293 H-InvDB: KLHL13

    (According to HUGE)
    About This Section
    HUGE: KIAA1309

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL13 gene:
    Search GeneIP for patents involving KLHL13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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