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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL13 Gene

protein-coding   GIFtS: 54
GCID: GC0XM117031

kelch-like family member 13

(Previous names: BTB and kelch domain containing 2, KIAA1309, kelch-like...)
(Previous symbols: BKLHD2, KIAA1309)
 Explore 2 diseases affiliated with
KLHL13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KLHL13    

Aliases
for KLHL13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kelch-Like Family Member 131 2     Kelch-Like 13 (Drosophila)1
BKLHD21 2 3     BTB And Kelch Domain Containing 22
KIAA13091 3     Kelch-Like 132
FLJ102621     Kelch-Like Protein 132
BTB And Kelch Domain Containing 2, KIAA13091     BTB And Kelch Domain-Containing Protein 23

External Ids:    HGNC: 229311   Entrez Gene: 902932   Ensembl: ENSG000000030967   OMIM: 3006555   UniProtKB: Q9P2N73   

Export aliases for KLHL13 gene to outside databases

Previous GC identifers: GC0XM115786 GC0XM116813 GC0XM116915 GC0XM106526


Summaries
for KLHL13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KLHL13:
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing
superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other
proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper
chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants.
(provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: KLH13_HUMAN, Q9P2N7
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic
progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB
and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression
and completion of cytokinesis




Genomic Views
for KLHL13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL13 gene promoter:
         ISGF-3   Sox5   AML1a   Pax-6   Nkx2-2   HSF1 (long)   E4BP4   FOXC1   Cart-1   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLHL13 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHL13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23-q24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq23-q24

KLHL13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL13 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM117031:  view genomic region     (about GC identifiers)

Start:
 117,031,776 bp from pter      End:
 117,251,303 bp from pter
Size:
 219,528 bases      Orientation:
 minus strand

Proteins
for KLHL13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KLH13_HUMAN, Q9P2N7 (See protein sequence)
Recommended Name: Kelch-like protein 13  
Size: 655 amino acids; 73868 Da
Subunit: Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and
RBX1. Interacts with AURKB
Sequence caution: Sequence=BAA92547.1; Type=Erroneous initiation; Sequence=CAC41335.1; Type=Erroneous initiation;
Secondary accessions: B3KV78 B3KWM7 B7Z3S9 B7Z5P2 B7Z802 D3DWH6 Q6P2E3 Q96QI7 Q9UDN9
Alternative splicing: 5 isoforms:  Q9P2N7-1   Q9P2N7-2   Q9P2N7-3   Q9P2N7-4   Q9P2N7-5   

Explore the universe of human proteins at neXtProt for KLHL13: NX_Q9P2N7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2N7

    • KLHL13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001161771.1  NP_001161772.1  NP_001161773.1  NP_001161774.1  NP_001161775.1  NP_277030.2  

    ENSEMBL proteins: 
     ENSP00000360949   ENSP00000360943   ENSP00000360945   ENSP00000412640   ENSP00000419803  
     ENSP00000393807   ENSP00000444450   ENSP00000441029   ENSP00000443191   ENSP00000262820  
     ENSP00000440707  
    Reactome Protein details: Q9P2N7
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: KLHL13
    OriGene Protein Over-expression Lysate: KLHL13
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    Novus Biologicals KLHL13 Protein
    Novus Biologicals KLHL13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KLHL13

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0031463Cul3-RING ubiquitin ligase complex IDA17543862


    KLHL13 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KLHL13

    Protein Domains /
    Families
    for KLHL13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KLHL13 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017096 Kelch-like_gigaxonin
     IPR000210 BTB/POZ-like
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR015916 Gal_Oxidase_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q9P2N7

    ProtoNet protein and cluster: Q9P2N7

    2 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH13_HUMAN, Q9P2N7
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Function
    for KLHL13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KLH13_HUMAN, Q9P2N7
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic
    progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB
    and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression
    and completion of cytokinesis

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL13
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL13 (see all 9):
    hsa-miR-548p hsa-miR-938 hsa-miR-218 hsa-miR-646 hsa-miR-421 hsa-miR-4275 hsa-miR-129-3p hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmid: KLHL13 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL13 (see all 3)
    OriGene siRNA: KLHL13
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KLHL13

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL13 (see all 7)
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL13

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA17543862


    KLHL13 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for KLHL13:
     Cell cycle / mitosis defect  Decreased nuclei size in G2M  Increased G1 DNA content 


    Pathways & Interactions
    for KLHL13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    		Ubiquitin mediated proteolysis0.36
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3Aurora B signaling
    		Aurora B signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for KLHL13 
        Aurora B signaling

    5        Reactome Pathways for KLHL13
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for KLHL13):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: KLH13_HUMAN, Q9P2N7
    Pathway: Protein modification; protein ubiquitination


    KLHL13 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for KLHL13 (Q9P2N73 ENSP000002628204) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    KLHL22Q53GT13, ENSP000003316824I2D: score=2 STRING: ENSP00000331682
    NUDCD3Q8IVD93, ENSP000003476264I2D: score=2 STRING: ENSP00000347626
    UBXN7O948883, ENSP000002963284I2D: score=2 STRING: ENSP00000296328
    ZMYM4Q5VZL53, ENSP000003229154I2D: score=2 STRING: ENSP00000322915
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP17543862
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination IDA17543862


    KLHL13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KLHL13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL13
    Search CenterWatch for drugs/clinical trials and news about KLHL13 / KLH13 

    Transcripts
    for KLHL13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KLHL13 gene (6 alternative transcripts): 
    NM_001168299.1  NM_001168300.1  NM_001168301.1  NM_001168302.1  NM_001168303.1  NM_033495.3  

    Unigene Cluster for KLHL13:

    Kelch-like 13 (Drosophila)
    Hs.348262  [show with all ESTs]
    Unigene Representative Sequence: NM_033495
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371882 ENST00000371876(uc004eqk.3) ENST00000371878 ENST00000447671
    ENST00000469946 ENST00000453826 ENST00000541812(uc022cde.1) ENST00000540167(uc011mtq.2)
    ENST00000539496(uc011mtp.2) ENST00000262820(uc004eql.3 uc011mtn.2 uc011mto.2)
    ENST00000545703(uc004eqm.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: KLHL13
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL13
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL13 (see all 9):
    hsa-miR-548p hsa-miR-938 hsa-miR-218 hsa-miR-646 hsa-miR-421 hsa-miR-4275 hsa-miR-129-3p hsa-miR-2113
    SwitchGear 3'UTR luciferase reporter plasmid: KLHL13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL13 (see all 3)
    OriGene siRNA: KLHL13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL13
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL13 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL13 (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): KLHL13 (NM_033495)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL13 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL13

    Additional cDNA sequence: 

    AK001124.1 AK122724.1 AK125356.1 AK296324.1 AK297523.1 AK299257.1 AK302713.1 AK316509.1 
    AL591986.1 BC008729.2 BC064576.1 

    8 DOTS entries:

    DT.100666713  DT.100743166  DT.121307029  DT.110413  DT.121306993  DT.121307071  DT.92420770  DT.95184327 

    24/66 AceView cDNA sequences (see all 66):

    BI549139 BC064576 AW519303 BU618521 BM699109 AK122724 BM680509 AA620455 
    BC008729 AA086182 N22179 AL591986 AI755242 NM_033495 BM669767 AI628964 
    AB037730 BU607845 AI800541 AI753736 CR614631 BP360232 BM718058 AU120580 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL13    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                      -     -                                             
    SP2:                                                                                          
    SP3:                    -     -           -     -                                             
    SP4:                    -                                                                     
    SP5:                                                                                          


    ECgene alternative splicing isoforms for KLHL13

    Expression
    for KLHL13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTATCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KLHL13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See KLHL13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL13

    SOURCE GeneReport for Unigene cluster: Hs.348262
        SABiosciences Expression via Pathway-Focused PCR Arrays including KLHL13: 
              Prostate Cancer in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL13

    Orthologs
    for KLHL13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KLHL13 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.35602 Transcribed sequence with strong similarity to protein more 84.97(n)    AL847812.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1630086
    si:rp71-68n21.96
    		 si:rp71-68n21.9
    		 90(a)
    55(a)
    		 1 ↔ many
    possible ortholog
    		 5(38943853-39040612)
    9(22198362-22208981)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG18126
    		 --
    		 25(a)
    		 1 → many
    		 X(20382574-20386859)


    ENSEMBL Gene Tree for KLHL13 (if available)
    TreeFam Gene Tree for KLHL13 (if available) 

    Paralogs
    for KLHL13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL13 gene
    KLHL422  KLHL222  KLHL262  KLHL342  KBTBD132  KBTBD112  KLHL312  KLHL92  
    KLHL322  KLHL142  KLHDC7B2  KLHL152  KLHL362  KLHL332  KLHDC7A2  
    18/28 SIMAP similar genes for KLHL13 using alignment to 3 protein entries:     KLH13_HUMAN (see all proteins) (see all similar genes):
    DKFZp686L0695    KLHL9    KLHL26    FLJ00127    KBTBD3    KLHL36
    KLHL31    BACH2    KLHL32    KLHL3    KIAA1900    KLHL14
    KLHL15    KLHL5    DKFZp761P1717    KLHL2    KLHL23    KLHL28

    KLHL13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KLHL13
    PGOHUM00000260454


    Genomic Variants
    for KLHL13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2834 NCBI SNPs in KLHL13 are shown (see all 2834)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs626092131,2
    		C,--117031339(+) GATCAT/CAATAC 6 -- ds50011Minor allele frequency- C:0.00NA 2
    rs1491209191,2
    		--117031422(+) TAAGGC/TAATTT 6 -- ds50010--------
    rs1923650771,2
    		--117031476(+) TCAGGA/GAGACT 6 -- ds50010--------
    rs66454121,2
    		C,F,A,H,--117031488(+) AACTCA/GGAATT 6 -- ds500113Minor allele frequency- G:0.85NS EA NA 1402
    rs1478360731,2
    		--117031550(+) AAAGCC/TAGTTA 6 -- ds50010--------
    rs1837034781,2
    		--117031613(+) ATAAGG/TTTAGA 6 -- ds50010--------
    rs626092141,2
    		C,--117031744(+) GTCAAG/ATCAGA 6 -- ds50011Minor allele frequency- A:0.00NA 2
    rs2013423131,2
    		--117032149(+) TTTTT-/AAAAAA 6 -- ut310--------
    rs66454131,2
    		C,--117032177(+) GTGCAC/TGTGTG 6 -- ut31 ese30--------
    rs1391644551,2
    		--117032290(+) TCTCCG/TGTGTG 6 -- ut310--------

    HapMap Linkage Disequilibrium report for KLHL13 (117031776 - 117251303 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KLHL13: --
    Locus Specific Mutation Databases (LSDB): KLHL13

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    Disorders / Diseases
    for KLHL13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KLHL13 for disorders           About GeneDecksing

    OMIM gene information: 300655    OMIM disorders: --

    2 diseases for KLHL13:    About MalaCards
    prostate cancer    prostatitis


    Export disorders for KLHL13 gene to outside databases

    Publications
    for KLHL13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL13 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with KLHL13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. (PubMed id 19995937)1, 2 Maerki S....Peter M. (2009)
    3. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. (PubMed id 17543862)1, 2 Sumara I....Peter M. (2007)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)2 Varela I....Futreal P.A. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    External Searches for KLHL13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing KLHL13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90293 HGNC: 22931 AceView: KLHL13 Ensembl:ENSG00000003096 euGenes: HUgn90293
    ECgene: KLHL13 Kegg: 90293 H-InvDB: KLHL13

    Other Databases showing KLHL13 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1309

    Specialized Databases showing KLHL13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL13 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KLHL13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KLHL13 gene:
    Search GeneIP for patents involving KLHL13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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