Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KLHL12 Gene

protein-coding GIFtS: 52
GCID: GC01M202860

kelch-like family member 12

(Previous name: kelch-like 12 (Drosophila) )

Explore 4 diseases affiliated with
KLHL12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kelch-Like Family Member 12¹ ²		Kelch-Like 12 (Drosophila)¹
C3IP1¹ ² ³		DKIR²
CUL3-Interacting Protein 1² ³		Kelch-Like 12²
DKIR Homolog² ³		Kelch-Like Protein 12²
HDKIR¹		Kelch-Like Protein C3IP1²

External Ids:	HGNC: 19360¹	Entrez Gene: 59349²	Ensembl: ENSG00000117153⁷	OMIM: 614522⁵	UniProtKB: Q53G59³

Export aliases for KLHL12 gene to outside databases

Previous GC identifers: GC01M200149 GC01M199591 GC01M201126 GC01M174025

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59

Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative

regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport

by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic

stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the

BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and

subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to

degradation of DRD4

Gene Wiki entry for KLHL12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLHL12 gene promoter:
NCX/Ncx Tal-1beta Meis-1b AREB6 HOXA5 Zic1 Meis-1a Msx-1 ITF-2 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLHL12 promoter sequence

Search SABiosciences Chromatin IP Primers for KLHL12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1

KLHL12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL12 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M202860: view genomic region (about GC identifiers)

Start:	202,860,228 bp from pter	End:	202,897,764 bp from pter
Size:	37,537 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59 (See protein sequence)

Recommended Name: Kelch-like protein 12

Size: 568 amino acids; 63277 Da

Subunit: Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. This

complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. Interacts with DRD4, KLHL12 and

SEC31A

Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle

1 PDB 3D structure from and Proteopedia for KLHL12:

2VPJ (3D)

Secondary accessions: A6NEN8 B7Z7B8 Q9HBX5

Alternative splicing: 2 isoforms: Q53G59-1 Q53G59-2

Explore the universe of human proteins at neXtProt for KLHL12: NX_Q53G59

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q53G59

KLHL12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_067646.1

ENSEMBL proteins:

ENSP00000356230 ENSP00000356228 ENSP00000356227 ENSP00000416886

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: KLHL12 OriGene Custom Protein Services for KLHL12
	GenScript Custom Purified and Recombinant Proteins Services for KLHL12
	Novus Biologicals KLHL12 Protein Novus Biologicals KLHL12 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KLHL12

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030134	ER to Golgi transport vesicle	IDA	--
GO:0031463	Cul3-RING ubiquitin ligase complex	IDA	--

KLHL12 for ontologies About GeneDecksing

KLHL12 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for KLHL12
	Browse OriGene Antibodies OriGene Custom Antibody Services for KLHL12
	GenScript Custom Superior Antibodies Services for KLHL12
	Novus Biologicals KLHL12 Antibodies
	Search for Antibodies for KLHL12 at Abcam
	Uscn Antibodies for KLHL12
	ThermoFisher Antibodies for KLHL12

Assay Products for KLHL12:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KLHL12
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLHL12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLHL12 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR017096 Kelch-like_gigaxonin

IPR000210 BTB/POZ-like

IPR006652 Kelch_1

IPR011333 BTB/POZ_fold

IPR015916 Gal_Oxidase_b-propeller

Graphical View of Domain Structure for InterPro Entry Q53G59

ProtoNet protein and cluster: Q53G59

3 Blocks protein families:

IPB000210 BTB/POZ domain

IPB006651 Kelch repeat signature

IPB011705 BTB/Kelch-associated

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59

Domain: The BTB domain is required for interaction with CUL3

Similarity: Contains 1 BACK (BTB/Kelch associated) domain

Similarity: Contains 1 BTB (POZ) domain

Similarity: Contains 6 Kelch repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59

Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative

regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport

by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic

stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the

BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and

subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to

degradation of DRD4

miRNA Products:		miRTarBase miRNAs that target KLHL12: hsa-mir-373 (MIRT002506)

		OriGene 3'-UTR Clone: KLHL12 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL12
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL12 (see all 23):
		hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-106a hsa-miR-93 hsa-miR-889 hsa-miR-3121-3p hsa-miR-526b*

		SwitchGear 3'UTR luciferase reporter plasmid: KLHL12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL12 (see all 7) OriGene shRNA RFP: KLHL12 OriGene siRNA: KLHL12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL12

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KLHL12

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL12 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KLHL12 (NM_021633)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL12

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KLHL12
		Search LifeMap BioReagents cell lines for KLHL12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL12

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16713569

KLHL12 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for KLHL12:

Increased G1 DNA content

Increased cilium length after

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Canonical Wnt signaling pathway

Canonical Wnt signaling pathway

1.00

Protein Stability

Protein Stability

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for KLHL12

Protein Stability

1 BioSystems Pathway for KLHL12

Canonical Wnt signaling pathway

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59

Pathway: Protein modification; protein ubiquitination

KLHL12 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLHL12

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for KLHL12 (Q53G59^{1, 2, 3} ENSP00000356230⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN1	P54253¹^,²^,³, ENSP00000244769⁴	EBI-740929,EBI-930964 MINT-2875559 MINT-2855203 I2D: score=3 STRING: ENSP00000244769
CPSF6	Q16630²^,³, ENSP00000391774⁴	MINT-67222 I2D: score=5 STRING: ENSP00000391774
LNX1	Q8TBB1²^,³, ENSP00000263925⁴	MINT-66959 I2D: score=5 STRING: ENSP00000263925
MED28	Q9H204²^,³, ENSP00000237380⁴	MINT-66369 I2D: score=5 STRING: ENSP00000237380
PRR13	Q9NZ81²^,³, ENSP00000412064⁴	MINT-66126 I2D: score=4 STRING: ENSP00000412064

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006513	protein monoubiquitination	IDA	--
GO:0006888	ER to Golgi vesicle-mediated transport	IDA	--
GO:0016055	Wnt receptor signaling pathway	IMP	--
GO:0048208	COPII vesicle coating	IMP	--

KLHL12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLHL12
Search CenterWatch for drugs/clinical trials and news about KLHL12 / KLH12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLHL12 gene:

NM_021633.2

Unigene Cluster for KLHL12:

Kelch-like 12 (Drosophila)

Hs.706793 [show with all ESTs]

Unigene Representative Sequence: NM_021633

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367261(uc001gyn.1 uc001gyo.1 uc009xah.1 uc010pqc.1)

ENST00000367259(uc001gym.1) ENST00000367258 ENST00000435533

miRNA Products:		OriGene 3'-UTR Clone: KLHL12 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL12
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL12 (see all 23):
		hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-106a hsa-miR-93 hsa-miR-889 hsa-miR-3121-3p hsa-miR-526b*

		SwitchGear 3'UTR luciferase reporter plasmid: KLHL12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL12 (see all 7) OriGene shRNA RFP: KLHL12 OriGene siRNA: KLHL12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL12

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL12 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL12 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KLHL12 (NM_021633)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL12
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KLHL12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL12

Additional cDNA sequence:

AF190900.1 AF306687.1 AF306689.1 AK024412.1 AK027656.1 AK130662.1 AK223072.1 AK301791.1

BC003183.1 BC004175.2

9 DOTS entries:

DT.116274 DT.100784180 DT.100025398 DT.100784179 DT.97846638 DT.100784178 DT.85105660 DT.120668416

DT.95206014

24/246 AceView cDNA sequences (see all 246):

AI283713 BM141755 AA227427 BM713730 BM785054 T09114 AI379069 AW473241

BX280504 AI804096 BQ000421 AF190900 AI279719 BC003183 CK819843 AI262801

AI128884 AI436238 AI468687 BQ422098 AA314329 CK819844 AF306689 BM826174

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLHL12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTGAAATT

About this image
See KLHL12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL12

SOURCE GeneReport for Unigene cluster: Hs.706793

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59

Tissue specificity: Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular

salivary gland

SABiosciences Custom PCR Arrays for KLHL12

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KLHL12
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KLHL12 gene from 5/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KLHL12¹	kelch-like 12 (Drosophila)	79.85(n) 96.82(a)		421171 XM_419251.3 XP_419251.3
lizard (Anolis carolinensis)	Reptilia	KLHL12⁶	--	96(a)	1 ↔ 1	4(133708567-133726541)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32296²	Xenopus laevis transcribed sequence with moderate similarity more	76.25(n)		BU915884.1
zebrafish (Danio rerio)	Actinopterygii	wufi60g03²	Transcribed sequence with moderate similarity to protein more	76.68(n)		BM890001.1
worm (Caenorhabditis elegans)	Secernentea	C53A5.9⁶ C53A5.11⁶ (see all 7)	Protein C53A5.11 (see all 7)	18(a) 17(a) (see all 7)	possible ortholog possible ortholog (see all 7)	V(14557023-14558903) V(14562550-14564624)

ENSEMBL Gene Tree for KLHL12 (if available)
TreeFam Gene Tree for KLHL12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KLHL12 gene

KLHL17² KLHL18² KLHL20² KLHL5² KEAP1² KLHL28² KLHL4² IPP²

KLHL3² KLHL8² KLHL10² KLHL1² KLHL2²

18/36 SIMAP similar genes for KLHL12 using alignment to 3 protein entries: KLH12_HUMAN (see all proteins) (see all similar genes):

BACH2 KBTBD3 KLHL3 KLHL20 KLHL4 KLHL17

KLHL1 DKFZp686H07112 KLHL18 KLHL28 KLHL5 KLHL32

KLHL2 DKFZp686P15123 DKFZp761P1717 DKFZp781C1855 KLHL8 IVNS1ABP

KLHL12 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KLHL12
PGOHUM00000259714

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188784016^1,2		--	202860629(+)	`TAAAAG/TAATGG`	1	--	ut3¹		0	--	--	--	--
rs139515782^1,2		--	202860631(+)	`AAAGAA/CTGGGG`	1	--	ut3¹		0	--	--	--	--
rs6427976^1,2	C,F,A,H,	--	202860739(+)	`ACAAAG/TAAAGG`	1	--	ut3¹		14		NS EA NA WA	1838
rs149693591^1,2		--	202860933(+)	`TCGGGA/GAAATA`	1	--	ut3¹		0	--	--	--	--
rs192877710^1,2		--	202861087(+)	`AAGAAC/GTGTCA`	1	--	ut3¹		0	--	--	--	--
rs201375357^1,2	C	--	202861211(+)	`TCCTGA/GAAAAA`	1	--	ut3¹		0	--	--	--	--
rs200246888^1,2	C	--	202861225(-)	`CAAGTC/TTNNNN`	1	--	ut3¹		0	--	--	--	--
rs74707906^1,2	C,	--	202861463(+)	`AATAT-/CTGGTTAC`	2	--	ut3¹		0	--	--	--	--
rs35443455^1,2	C	--	202861464(+)	`AATAT-/CTGTTACC`	2	--	ut3¹		4		NA CSA	8
rs200666052^1,2	C	--	202861464(+)	`AATATC/TTNNNN`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KLHL12 (202860228 - 202897764 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLHL12: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL12

DNA2.0 Custom Variant and Variant Library Synthesis for KLHL12

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLHL12 for disorders           About GeneDecksing

OMIM gene information: 614522    OMIM disorders: --

4 diseases for KLHL12:    About MalaCards

typhoid fever essential hypertension hypertension ataxia

Human Genome Epidemiology (HuGE) Navigator: KLHL12 (1 document)

Export disorders for KLHL12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KLHL12 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with KLHL12)

Utopia: connect your pdf to the dynamic
world of online information

KLHL12-mediated ubiquitination of the dopamine D4 rec eptor does not target the receptor for degradation. (PubMed id 20100572)^{1, 2} Rondou P....Van Craenenbroeck K. (2010)
BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. (PubMed id 18303015)^{1, 2} Rondou P....Van Craenenbroeck K. (2008)
The KLHL12-cullin-3 ubiquitin ligase negatively regulates the Wnt- beta-catenin pathway by targeting Dishevelled for degradation. (PubMed id 16547521)^{1, 2} Angers S.... Moon R.T. (2006)
Identification of specific autoantigens in Sjoegren's syndrome by SEREX. (PubMed id 16108817)^{1, 2} Uchida K.... Kozaki K. (2005)
hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure. (PubMed id 15383316)^{1, 2} Mai A....Yonehara S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Ubiquitin-dependent regulation of COPII coat size and function. (PubMed id 22358839)² Jin L.... Rape M. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 59349	HGNC: 19360	AceView: KLHL12	Ensembl:ENSG00000117153	euGenes: HUgn59349
ECgene: KLHL12	H-InvDB: KLHL12

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KLHL12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KLHL12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KLHL12 gene:
Search GeneIP for patents involving KLHL12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for KLHL12
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL12		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL12
	OriGene Protein Over-expression Lysate for KLHL12		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for KLHL12		OriGene 3'-UTR Clone for KLHL12
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL12		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL12
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for KLHL12		OriGene Custom Protein Services for KLHL12
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL12
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL12
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL12
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL12
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL12
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL12

	GenScript Custom Purified and Recombinant Proteins Services for KLHL12		GenScript cDNA clones with any tag delivered in your preferred vector for KLHL12
	GenScript Custom Assay Services for KLHL12		GenScript Custom Superior Antibodies Services for KLHL12
	GenScript Custom overexpressing Cell Line Services for KLHL12		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for KLHL12

	Regulatory tfbs in KLHL12 promoter
	Search Chromatin IP Primers for KLHL12
	RT² qPCR Primer Assay in human, mouse, rat KLHL12
	GNC Network for KLHL12
	SABiosciences Custom PCR Arrays for KLHL12

Search Tocris compounds for KLHL12

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	KLHL12 antibodies
	KLHL12 proteins
	KLHL12 lysates

	Search for Antibodies for KLHL12 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for KLHL12
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

KLHL12 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for KLHL12

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL12

	SwitchGear 3'UTR luciferase reporter plasmids for KLHL12
	SwitchGear Promoter luciferase reporter plasmids for KLHL12

ThermoFisher Antibodies for KLHL12

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL12

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KLHL12 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

KLHL12 Gene

kelch-like family member 12

Aliases
for KLHL12 gene

Summaries
for KLHL12 gene

Genomic Views
for KLHL12 gene

Proteins
for KLHL12 gene

Protein Domains /
Families
for KLHL12 gene

Function
for KLHL12 gene

Pathways & Interactions
for KLHL12 gene

Drugs & Compounds
for KLHL12 gene

Transcripts
for KLHL12 gene

Expression
for KLHL12 gene

Orthologs
for KLHL12 gene

Paralogs
for KLHL12 gene

Genomic Variants
for KLHL12 gene

Disorders / Diseases
for KLHL12 gene

Publications
for KLHL12 gene

External Searches for KLHL12 gene

Genome Databases showing KLHL12 gene

Other Databases showing KLHL12 gene

Specialized Databases showing KLHL12 gene

Intellectual Property
for KLHL12 gene

Products
for KLHL12 gene

View Random Gene

Advanced Search

Export list of displayed genes

KLHL12 Gene

kelch-like family member 12

Aliasesfor KLHL12 gene

Summariesfor KLHL12 gene

Genomic Viewsfor KLHL12 gene

Proteinsfor KLHL12 gene

Protein Domains /Familiesfor KLHL12 gene

Functionfor KLHL12 gene

Pathways & Interactionsfor KLHL12 gene

Drugs & Compoundsfor KLHL12 gene

Transcriptsfor KLHL12 gene

Expression for KLHL12 gene

Orthologsfor KLHL12 gene

Paralogsfor KLHL12 gene

Genomic Variantsfor KLHL12 gene

Disorders / Diseasesfor KLHL12 gene

Publicationsfor KLHL12 gene

External Searches for KLHL12 gene

Genome Databases showing KLHL12 gene

Other Databases showing KLHL12 gene

Specialized Databases showing KLHL12 gene

Intellectual Propertyfor KLHL12 gene

Productsfor KLHL12 gene

View Random Gene

Aliases
for KLHL12 gene

Summaries
for KLHL12 gene

Genomic Views
for KLHL12 gene

Proteins
for KLHL12 gene

Protein Domains /
Families
for KLHL12 gene

Function
for KLHL12 gene

Pathways & Interactions
for KLHL12 gene

Drugs & Compounds
for KLHL12 gene

Transcripts
for KLHL12 gene

Expression
for KLHL12 gene

Orthologs
for KLHL12 gene

Paralogs
for KLHL12 gene

Genomic Variants
for KLHL12 gene

Disorders / Diseases
for KLHL12 gene

Publications
for KLHL12 gene

Intellectual Property
for KLHL12 gene

Products
for KLHL12 gene