Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KLHL12 Gene

protein-coding   GIFtS: 52
GCID: GC01M202860

Kelch-Like Family Member 12

(Previous name: kelch-like 12 (Drosophila))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Kelch-Like Family Member 121 2     DKIR2 5
C3IP12 3     Kelch-Like 12 (Drosophila)1
CUL3-Interacting Protein 12 3     Kelch-Like 122
DKIR Homolog2 3     Kelch-Like Protein 122
hDKIR2 3     Kelch-Like Protein C3IP12

External Ids:    HGNC: 193601   Entrez Gene: 593492   Ensembl: ENSG000001171537   OMIM: 6145225   UniProtKB: Q53G593   

Export aliases for KLHL12 gene to outside databases

Previous GC identifers: GC01M200149 GC01M199591 GC01M201126 GC01M174025


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KLHL12 Gene:
KLHL12 (kelch-like family member 12) is a protein-coding gene. An important paralog of this gene is KLHL17.

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative
regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi
transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required
for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or
SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by
mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates
polyubiquitination of DRD4, without leading to degradation of DRD4

Gene Wiki entry for KLHL12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL12 gene promoter:
         NCX/Ncx   Tal-1beta   Meis-1b   AREB6   HOXA5   Zic1   Meis-1a   Msx-1   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL12 promoter sequence
   Search Chromatin IP Primers for KLHL12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

KLHL12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202860:  view genomic region     (about GC identifiers)

Start:
202,860,228 bp from pter      End:
202,897,764 bp from pter
Size:
37,537 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59 (See protein sequence)
Recommended Name: Kelch-like protein 12  
Size: 568 amino acids; 63277 Da
Subunit: Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1.
This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. Interacts with DRD4,
KLHL12 and SEC31A
1 PDB 3D structure from and Proteopedia for KLHL12:
2VPJ (3D)    
Secondary accessions: A6NEN8 B7Z7B8 Q9HBX5
Alternative splicing: 2 isoforms:  Q53G59-1   Q53G59-2   

Explore the universe of human proteins at neXtProt for KLHL12: NX_Q53G59

Explore proteomics data for KLHL12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLHL12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067646.1  
    ENSEMBL proteins: 
     ENSP00000356230   ENSP00000356228   ENSP00000356227   ENSP00000416886  
    Reactome Protein details: Q53G59

    KLHL12 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KLHL12
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KLHL12
    GenScript Custom Purified and Recombinant Proteins Services for KLHL12
    Novus Biologicals KLHL12 Protein
    Novus Biologicals KLHL12 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLHL12

     
    Search eBioscience for Proteins for KLHL12 

     
    antibodies-online proteins for KLHL12 (4 products) 

     
    antibodies-online peptides for KLHL12

    KLHL12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for KLHL12 
    OriGene Antibodies for KLHL12
    OriGene Custom Antibody Services for KLHL12
    Novus Biologicals KLHL12 Antibodies
    Abcam antibodies for KLHL12
    Cloud-Clone Corp. Antibodies for KLHL12
    ThermoFisher Antibodies for KLHL12
    antibodies-online antibodies for KLHL12 (30 products) 

    KLHL12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLHL12
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLHL12
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLHL12
    Cloud-Clone Corp. CLIAs for KLHL12
    Search eBioscience for ELISAs for KLHL12 
    antibodies-online kits for KLHL12 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin-typ
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q53G59

    ProtoNet protein and cluster: Q53G59

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB006651 Kelch repeat signature
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
    Domain: The BTB domain is required for interaction with CUL3
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    Find genes that share domains with KLHL12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH12_HUMAN, Q53G59
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative
    regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi
    transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required
    for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or
    SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by
    mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates
    polyubiquitination of DRD4, without leading to degradation of DRD4

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with KLHL12           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KLHL12:
     Increased G1 DNA content  Increased cilium length after  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KLHL12

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLHL12:
    hsa-mir-365a-3p (MIRT044028), hsa-mir-28-5p (MIRT050001), hsa-mir-148b-3p (MIRT019284), hsa-mir-373-3p (MIRT002506)

    Block miRNA regulation of human, mouse, rat KLHL12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL12 (see all 23):
    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-106a hsa-miR-93 hsa-miR-889 hsa-miR-3121-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLHL12
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLHL12

    Clone
    Products:
         
    OriGene clones in human, mouse for KLHL12 (see all 6)
    OriGene ORF clones in mouse, rat for KLHL12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL12 (NM_021633)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL12
    Addgene plasmids for KLHL12 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLHL12
    Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL12 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KLH12_HUMAN, Q53G59: Cytoplasmic vesicle, COPII-coated vesicle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IMP--
    GO:0030134ER to Golgi transport vesicle IDA--
    GO:0031463Cul3-RING ubiquitin ligase complex IDA--

    Find genes that share ontologies with KLHL12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KLHL12 About    
    See pathways by source

    SuperPathContained pathways About
    1Protein Stability
    Protein Stability
    2Canonical Wnt signaling pathway
    Canonical Wnt signaling pathway


    Find genes that share SuperPaths with KLHL12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KLHL12
        Protein Stability

    1 BioSystems Pathway for KLHL12
        Canonical Wnt signaling pathway

    1 Reactome Pathway for KLHL12
        degradation of DVL


    UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL12
    Interactions:

        GeneGlobe Interaction Network for KLHL12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KLHL12 (Q53G591, 2, 3 ENSP000003562304) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-740929,EBI-930964 MINT-2875559 MINT-2855203 I2D: score=3 STRING: ENSP00000244769
    ENSG00000096155P463792, 3MINT-66953 I2D: score=5 
    ENSG00000227761P463792, 3MINT-66953 I2D: score=5 
    ENSG00000228760P463792, 3MINT-66953 I2D: score=5 
    ENSG00000229524P463792, 3MINT-66953 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006513protein monoubiquitination IDA--
    GO:0006888ER to Golgi vesicle-mediated transport IDA--
    GO:0016055Wnt signaling pathway IMP--
    GO:0048208COPII vesicle coating IMP--

    Find genes that share ontologies with KLHL12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL12 (KLH12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KLHL12 gene: 
    NM_021633.2  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367261(uc001gyn.1 uc001gyo.1 uc009xah.1 uc010pqc.1)
    ENST00000367259(uc001gym.1) ENST00000367258 ENST00000435533
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLHL12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHL12 (see all 23):
    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-106a hsa-miR-93 hsa-miR-889 hsa-miR-3121-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL12 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLHL12
    Predesigned siRNA for gene silencing in human, mouse, rat KLHL12
    Clone
    Products:
         
    OriGene clones in human, mouse for KLHL12 (see all 6)
    OriGene ORF clones in mouse, rat for KLHL12
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHL12 (NM_021633)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL12
    Addgene plasmids for KLHL12 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KLHL12
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL12
      QuantiTect SYBR Green Assays in human, mouse, rat KLHL12
      QuantiFast Probe-based Assays in human, mouse, rat KLHL12

    Selected AceView cDNA sequences (see all 246):

    AI276997 BX359647 AA455606 AA314329 W03357 BM998417 AA133404 AI378400 
    AF306689 AW474598 AA993170 BP358207 AI373159 BM141755 CB155441 BQ013245 
    N67795 AA227427 AU142066 AI129289 AA424925 CK819844 BX361618 AW473241 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KLHL12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGAAATT
    KLHL12 Expression
    About this image

    KLHL12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL12 Protein Expression

    UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
    Tissue specificity: Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular
    salivary gland

        Custom PCR Arrays for KLHL12
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KLHL12
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHL12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL12
    QuantiTect SYBR Green Assays in human, mouse, rat KLHL12
    QuantiFast Probe-based Assays in human, mouse, rat KLHL12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL12 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl121 , 5 kelch-like 12 (Drosophila)5
    kelch-like 121
    91(n)1
    99.26(a)1
      1 (58.23 cM)5
    2407561  NM_153128.21  NP_694768.11 
     1344555315 
    chicken
    (Gallus gallus)
    Aves LOC1017489771 kelch-like protein 12-like 77.76(n)
    92.63(a)
      101748977  XM_004934834.1  XP_004934891.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL126
    kelch-like family member 12
    96(a)
    1 ↔ 1
    4(133704511-133726541)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.322962 Xenopus laevis transcribed sequence with moderate similarity more 76.25(n)    BU915884.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi60g032 Transcribed sequence with moderate similarity to protein more 76.68(n)    BM890001.1 


    ENSEMBL Gene Tree for KLHL12 (if available)
    TreeFam Gene Tree for KLHL12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KLHL12 gene
    KLHL172  KLHL182  KLHL202  KLHL52  KEAP12  KLHL282  KLHL42  KLHL32  
    KLHL82  KLHL102  KLHL12  KLHL22  
    Selected SIMAP similar genes for KLHL12 using alignment to 3 protein entries:     KLH12_HUMAN (see all proteins) (see all similar genes):
    BACH2    KBTBD3    KLHL3    KLHL20    KLHL4    KLHL17
    KLHL1    DKFZp686H07112    KLHL18    KLHL28    KLHL32    DKFZp686P15123
    DKFZp761P1717    KLHL5    KLHL2    DKFZp781C1855    KLHL8    IVNS1ABP

    Find genes that share paralogs with KLHL12           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KLHL12
    PGOHUM00000259714


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KLHL12 (see all 813)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887840161,2
    --202860629(+) TAAAAG/TAATGG 1 -- ut310--------
    rs1395157821,2
    C--202860631(+) AAAGAA/CTGGGG 1 -- ut310--------
    rs64279761,2
    C,F,A,H--202860739(+) ACAAAG/TAAAGG 1 -- ut3114Minor allele frequency- T:0.03NS EA NA WA 1838
    rs1496935911,2
    --202860933(+) TCGGGA/GAAATA 1 -- ut310--------
    rs1928777101,2
    C--202861087(+) AAGAAC/GTGTCA 1 -- ut310--------
    rs2013753571,2
    C--202861211(+) TCCTGA/GAAAAA 1 -- ut310--------
    rs1412852951,2
    C--202861212(+) AAAAA-/A/AA  
            
    GACTT
    2 -- ut310--------
    rs2002468881,2
    C--202861225(-) CAAGTC/TTNNNN 1 -- ut310--------
    rs120895661,2
    C,F,H--202861342(+) ACAACA/GTACAT 1 -- ut3118Minor allele frequency- G:0.30NS EA NA WA CSA 1990
    rs747079061,2
    C--202861463(+) AATAT-/CTGGTTAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for KLHL12 (202860228 - 202897764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLHL12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832359CNV Loss17160897
    nsv873108CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL12
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614522    OMIM disorders: --


    Find genes that share disorders with KLHL12           About GenesLikeMe

    Genetic Association Database (GAD): KLHL12
    Human Genome Epidemiology (HuGE) Navigator: KLHL12 (1 document)

    Export disorders for KLHL12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KLHL12 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with KLHL12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation. (PubMed id 20100572)1, 2 Rondou P.... Van Craenenbroeck K. (Cell. Signal. 2010)
    2. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    3. BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. (PubMed id 18303015)1, 2 Rondou P.... Van Craenenbroeck K. (J. Biol. Chem. 2008)
    4. The KLHL12-cullin-3 ubiquitin ligase negatively regulates the Wnt- beta-catenin pathway by targeting Dishevelled for degradation. (PubMed id 16547521)1, 2 Angers S.... Moon R.T. (Nat. Cell Biol. 2006)
    5. Identification of specific autoantigens in Sjoegren's syndrome by SEREX. (PubMed id 16108817)1, 2 Uchida K.... Kozaki K. (Immunology 2005)
    6. hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure. (PubMed id 15383316)1, 2 Mai A.... Yonehara S. (Exp. Cell Res. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PubMed id 23349464)2 Canning P.... Bullock A.N. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 59349 HGNC: 19360 AceView: KLHL12 Ensembl:ENSG00000117153 euGenes: HUgn59349
    ECgene: KLHL12 H-InvDB: KLHL12

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KLHL12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KLHL12 gene:
    Search GeneIP for patents involving KLHL12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KLHL12   OriGene RNAi products in human, mouse, rat for KLHL12  
     OriGene qPCR primer pairs and template standards for KLHL12   OriGene Protein Over-expression Lysate for KLHL12  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KLHL12  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLHL12   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KLHL12   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLHL12   OriGene Custom Protein Services for KLHL12  

     
     
     Block miRNA regulation of human, mouse, rat KLHL12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLHL12
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL12 Predesigned siRNA for gene silencing in human, mouse, rat KLHL12
     QuantiFast Probe-based Assays in human, mouse, rat KLHL12 QuantiTect SYBR Green Assays in human, mouse, rat KLHL12
     Custom PCR Arrays for KLHL12 Search Chromatin IP Primers for KLHL12
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL12  GeneGlobe Interaction Network for KLHL12
     Regulatory tfbs in KLHL12 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KLHL12 GenScript cDNA clones with any tag delivered in your preferred vector for KLHL12
     GenScript Custom Assay Services for KLHL12 GenScript Custom overexpressing Cell Line Services for KLHL12
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for KLHL12 

     Search Tocris compounds for KLHL12 (KLH12)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KLHL12 antibodies
     KLHL12 proteins
     KLHL12 lysates
     Antibodies for KLHL12
     See all of Abcam's Antibodies, Kits and Proteins for KLHL12
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KLHL12
     Antibodies for KLHL12
     ELISAs for KLHL12
     CLIAs for KLHL12



     Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL12
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL12
     SwitchGear 3'UTR luciferase reporter plasmids for KLHL12
     SwitchGear Promoter luciferase reporter plasmids for KLHL12
     ThermoFisher Antibodies for KLHL12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL12
     Browse compounds at ApexBio
     Addgene plasmids for KLHL12
      Search eBioscience for proteins for KLHL12
      Search eBioscience for elisas for KLHL12
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for KLHL12
     antibodies-online antibodies for KLHL12 (30 products)
     antibodies-online kits for KLHL12 (6 products)
     antibodies-online peptides for KLHL12
     antibodies-online proteins for KLHL12 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLHL12 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4