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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL12 Gene

protein-coding   GIFtS: 55
GCID: GC01M202860

Kelch-Like Family Member 12

(Previous name: kelch-like 12 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 121 2     Kelch-Like 12 (Drosophila)1
C3IP12 3     DKIR2
CUL3-Interacting Protein 12 3     Kelch-Like 122
DKIR Homolog2 3     Kelch-Like Protein 122
hDKIR2 3     Kelch-Like Protein C3IP12

External Ids:    HGNC: 193601   Entrez Gene: 593492   Ensembl: ENSG000001171537   OMIM: 6145225   UniProtKB: Q53G593   

Export aliases for KLHL12 gene to outside databases

Previous GC identifers: GC01M200149 GC01M199591 GC01M201126 GC01M174025


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLHL12 Gene: 
KLHL12 (kelch-like family member 12) is a protein-coding gene. Diseases associated with KLHL12 include typhoid fever, and essential hypertension. GO annotations related to this gene include protein binding. An important paralog of this gene is KLHL17.

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative
regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi
transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required
for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or
SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by
mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates
polyubiquitination of DRD4, without leading to degradation of DRD4

Gene Wiki entry for KLHL12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL12 gene promoter:
         NCX/Ncx   Tal-1beta   Meis-1b   AREB6   HOXA5   Zic1   Meis-1a   Msx-1   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL12 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHL12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

KLHL12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202860:  view genomic region     (about GC identifiers)

Start:
202,860,228 bp from pter      End:
202,897,764 bp from pter
Size:
37,537 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59 (See protein sequence)
Recommended Name: Kelch-like protein 12  
Size: 568 amino acids; 63277 Da
Subunit: Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1.
This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. Interacts with DRD4,
KLHL12 and SEC31A
Subcellular location: Cytoplasmic vesicle, COPII-coated vesicle
1 PDB 3D structure from and Proteopedia for KLHL12:
2VPJ (3D)    
Secondary accessions: A6NEN8 B7Z7B8 Q9HBX5
Alternative splicing: 2 isoforms:  Q53G59-1   Q53G59-2   

Explore the universe of human proteins at neXtProt for KLHL12: NX_Q53G59

Explore proteomics data for KLHL12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q53G59

  • KLHL12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL12 Protein Expression
    REFSEQ proteins: NP_067646.1  
    ENSEMBL proteins: 
     ENSP00000356230   ENSP00000356228   ENSP00000356227   ENSP00000416886  

    Human Recombinant Protein Products for KLHL12: 
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    Cloud-Clone Corp. Proteins for KLHL12 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030134ER to Golgi transport vesicle IDA--
    GO:0031463Cul3-RING ubiquitin ligase complex IDA--

    KLHL12 for ontologies           About GeneDecksing



    KLHL12 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    5/7 InterPro protein domains (see all 7):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR017096 Kelch-like_gigaxonin
     IPR015916 Gal_Oxidase_b-propeller
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q53G59

    ProtoNet protein and cluster: Q53G59

    3 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB006651 Kelch repeat signature
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
    Domain: The BTB domain is required for interaction with CUL3
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 6 Kelch repeats


    KLHL12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH12_HUMAN, Q53G59
    Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative
    regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi
    transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required
    for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or
    SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by
    mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates
    polyubiquitination of DRD4, without leading to degradation of DRD4

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    KLHL12 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KLHL12:
     Increased G1 DNA content  Increased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHL12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL12 

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLHL12:
    hsa-mir-373 (MIRT002506)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL12
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL12 (see all 23):
    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-106a hsa-miR-93 hsa-miR-889 hsa-miR-3121-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL12 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLHL12 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Canonical Wnt signaling pathway
    Canonical Wnt signaling pathway
    2Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KLHL12
        Protein Stability

    1 BioSystems Pathway for KLHL12
        Canonical Wnt signaling pathway


    UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
    Pathway: Protein modification; protein ubiquitination


    KLHL12 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLHL12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for KLHL12 (Q53G591, 2, 3 ENSP000003562304) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-740929,EBI-930964 MINT-2875559 MINT-2855203 I2D: score=3 STRING: ENSP00000244769
    ENSG00000096155P463792, 3MINT-66953 I2D: score=5 
    ENSG00000227761P463792, 3MINT-66953 I2D: score=5 
    ENSG00000228760P463792, 3MINT-66953 I2D: score=5 
    ENSG00000229524P463792, 3MINT-66953 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006513protein monoubiquitination IDA--
    GO:0006888ER to Golgi vesicle-mediated transport IDA--
    GO:0016055Wnt receptor signaling pathway IMP--
    GO:0048208COPII vesicle coating IMP--

    KLHL12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL12 (KLH12)

    Search CenterWatch for drugs/clinical trials and news about KLHL12 / KLH12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL12 gene: 
    NM_021633.2  

    Unigene Cluster for KLHL12:

    Kelch-like family member 12
    Hs.706793  [show with all ESTs]
    Unigene Representative Sequence: NM_021633
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367261(uc001gyn.1 uc001gyo.1 uc009xah.1 uc010pqc.1)
    ENST00000367259(uc001gym.1) ENST00000367258 ENST00000435533
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHL12
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHL12 (see all 23):
    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-3664-5p hsa-miR-106a hsa-miR-93 hsa-miR-889 hsa-miR-3121-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidKLHL12 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL12
    Clone
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    GenScript: all cDNA clones in your preferred vector: KLHL12 (NM_021633)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL12
    Sirion Biotech Customized lentivirus for stable overexpression of KLHL12 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL12

    Additional mRNA sequence: 

    AF190900.1 AF306687.1 AF306689.1 AK024412.1 AK027656.1 AK130662.1 AK223072.1 AK301791.1 
    BC003183.1 BC004175.2 

    9 DOTS entries:

    DT.116274  DT.100784180  DT.100025398  DT.100784179  DT.97846638  DT.100784178  DT.85105660  DT.120668416 
    DT.95206014 

    24/246 AceView cDNA sequences (see all 246):

    BM713730 AF190900 R63038 BX359647 BM141755 CB155441 W03357 N24733 
    BM670604 AA424925 BC004175 AI129289 AA227427 AI279719 BQ000421 BX361618 
    BM785054 BQ013245 AI373159 AI283713 AI468687 AI217593 AA442554 AI378400 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGAAATT
    KLHL12 Expression
    About this image


    See KLHL12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL12

    SOURCE GeneReport for Unigene cluster: Hs.706793

    UniProtKB/Swiss-Prot: KLH12_HUMAN, Q53G59
    Tissue specificity: Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular
    salivary gland

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL12 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl121 , 5 kelch-like 12 (Drosophila)1, 5 91(n)1
    99.26(a)1
      1 (58.23 cM)5
    2407561  NM_153128.21  NP_694768.11 
     1344555315 
    chicken
    (Gallus gallus)
    Aves KLHL121 kelch-like 12 (Drosophila) 79.85(n)
    96.82(a)
      421171  XM_419251.3  XP_419251.3 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL126
    Uncharacterized protein
    96(a)
    1 ↔ 1
    4(133704511-133726541)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.322962 Xenopus laevis transcribed sequence with moderate similarity more 76.25(n)    BU915884.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi60g032 Transcribed sequence with moderate similarity to protein more 76.68(n)    BM890001.1 


    ENSEMBL Gene Tree for KLHL12 (if available)
    TreeFam Gene Tree for KLHL12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL12 gene
    KLHL172  KLHL182  KLHL202  KLHL52  KEAP12  KLHL282  KLHL42  KLHL32  
    IPP2  KLHL82  KLHL102  KLHL12  KLHL22  
    18/33 SIMAP similar genes for KLHL12 using alignment to 3 protein entries:     KLH12_HUMAN (see all proteins) (see all similar genes):
    BACH2    KBTBD3    KLHL3    KLHL20    KLHL4    KLHL17
    KLHL1    DKFZp686H07112    KLHL18    KLHL28    KLHL32    DKFZp686P15123
    DKFZp761P1717    KLHL5    KLHL2    DKFZp781C1855    KLHL8    IVNS1ABP

    KLHL12 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KLHL12
    PGOHUM00000259714


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/813 SNPs in KLHL12 are shown (see all 813)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887840161,2
    --202860629(+) TAAAAG/TAATGG 1 -- ut310--------
    rs1395157821,2
    C--202860631(+) AAAGAA/CTGGGG 1 -- ut310--------
    rs64279761,2
    C,F,A,H--202860739(+) ACAAAG/TAAAGG 1 -- ut3114Minor allele frequency- T:0.03NS EA NA WA 1838
    rs1496935911,2
    --202860933(+) TCGGGA/GAAATA 1 -- ut310--------
    rs1928777101,2
    C--202861087(+) AAGAAC/GTGTCA 1 -- ut310--------
    rs2013753571,2
    C--202861211(+) TCCTGA/GAAAAA 1 -- ut310--------
    rs1412852951,2
    C--202861212(+) AAAAA-/A/AA  
            
    GACTT
    2 -- ut310--------
    rs2002468881,2
    C--202861225(-) CAAGTC/TTNNNN 1 -- ut310--------
    rs120895661,2
    C,F,H--202861342(+) ACAACA/GTACAT 1 -- ut3118Minor allele frequency- G:0.30NS EA NA WA CSA 1990
    rs747079061,2
    C--202861463(+) AATAT-/CTGGTTAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for KLHL12 (202860228 - 202897764 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLHL12:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832359CNV Loss17160897
    nsv873108CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614522    OMIM disorders: --

    3 diseases for KLHL12:    About MalaCards
    typhoid fever    essential hypertension    hypertension


    KLHL12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLHL12
    Human Genome Epidemiology (HuGE) Navigator: KLHL12 (1 document)

    Export disorders for KLHL12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL12 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with KLHL12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. KLHL12-mediated ubiquitination of the dopamine D4 rec eptor does not target the receptor for degradation. (PubMed id 20100572)1, 2 Rondou P....Van Craenenbroeck K. (2010)
    2. Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (2009)
    3. BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. (PubMed id 18303015)1, 2 Rondou P....Van Craenenbroeck K. (2008)
    4. The KLHL12-cullin-3 ubiquitin ligase negatively regulates the Wnt- beta-catenin pathway by targeting Dishevelled for degradation. (PubMed id 16547521)1, 2 Angers S.... Moon R.T. (2006)
    5. Identification of specific autoantigens in Sjoegren's syndrome by SEREX. (PubMed id 16108817)1, 2 Uchida K.... Kozaki K. (2005)
    6. hDKIR, a human homologue of the Drosophila kelch protein, involved in a ring-like structure. (PubMed id 15383316)1, 2 Mai A....Yonehara S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    10. Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PubMed id 23349464)2 Canning P.... Bullock A.N. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59349 HGNC: 19360 AceView: KLHL12 Ensembl:ENSG00000117153 euGenes: HUgn59349
    ECgene: KLHL12 H-InvDB: KLHL12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL12 gene:
    Search GeneIP for patents involving KLHL12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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