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Aliases for KLHL11 Gene

Aliases for KLHL11 Gene

  • Kelch-Like Family Member 11 2 3
  • Kelch-Like 11 (Drosophila) 2

External Ids for KLHL11 Gene

Previous GeneCards Identifiers for KLHL11 Gene

  • GC00U991260
  • GC17M040383
  • GC17M037263
  • GC17M040004
  • GC17M035772
  • GC17M040009

Summaries for KLHL11 Gene

GeneCards Summary for KLHL11 Gene

KLHL11 (Kelch-Like Family Member 11) is a Protein Coding gene. An important paralog of this gene is CCIN.

UniProtKB/Swiss-Prot for KLHL11 Gene

  • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL11 Gene

Genomics for KLHL11 Gene

Regulatory Elements for KLHL11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHL11 Gene

41,853,545 bp from pter
41,865,431 bp from pter
11,887 bases
Minus strand

Genomic View for KLHL11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL11 Gene

Proteins for KLHL11 Gene

  • Protein details for KLHL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 11
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KLHL11 Gene

    708 amino acids
    Molecular mass:
    80148 Da
    Quaternary structure:
    • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer. Interacts with CUL3.

    Three dimensional structures from OCA and Proteopedia for KLHL11 Gene

neXtProt entry for KLHL11 Gene

Proteomics data for KLHL11 Gene at MOPED

Post-translational modifications for KLHL11 Gene

  • Ubiquitination at Lys298, Lys454, Lys469, Lys480, Lys489, Lys521, and Lys682
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KLHL11 Gene

Domains for KLHL11 Gene

Gene Families for KLHL11 Gene

Protein Domains for KLHL11 Gene

Suggested Antigen Peptide Sequences for KLHL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 5 Kelch repeats.
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KLHL11: view

Function for KLHL11 Gene

Molecular function for KLHL11 Gene

UniProtKB/Swiss-Prot Function:
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Gene Ontology (GO) - Molecular Function for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL11: view

Phenotypes for KLHL11 Gene

GenomeRNAi human phenotypes for KLHL11:
genes like me logo Genes that share phenotypes with KLHL11: view

Animal Model Products

miRNA for KLHL11 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL11 Gene

Localization for KLHL11 Gene

Subcellular locations from

Jensen Localization Image for KLHL11 Gene COMPARTMENTS Subcellular localization image for KLHL11 gene
Compartment Confidence
cytosol 2
extracellular 2
endoplasmic reticulum 1
lysosome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL11 Gene

Pathways for KLHL11 Gene

SuperPathways for KLHL11 Gene

No Data Available

Interacting Proteins for KLHL11 Gene

Gene Ontology (GO) - Biological Process for KLHL11 Gene


No data available for Pathways by source for KLHL11 Gene

Transcripts for KLHL11 Gene

mRNA/cDNA for KLHL11 Gene

(125) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL11 Gene

Kelch-like family member 11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHL11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL11 Gene

No ASD Table

Relevant External Links for KLHL11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL11 Gene

mRNA expression in normal human tissues for KLHL11 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL11 Gene

This gene is overexpressed in Testis (6.4).

Protein differential expression in normal tissues for KLHL11 Gene

This gene is overexpressed in Pancreatic juice (29.6), Platelet (11.3), and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL11 Gene

SOURCE GeneReport for Unigene cluster for KLHL11 Gene Hs.592134

genes like me logo Genes that share expressions with KLHL11: view

Expression partners for KLHL11 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL11 Gene

Orthologs for KLHL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHL11 35
  • 91.57 (n)
  • 99.15 (a)
KLHL11 36
  • 100 (a)
(Canis familiaris)
Mammalia KLHL11 35
  • 93.13 (n)
  • 99.44 (a)
KLHL11 36
  • 99 (a)
(Mus musculus)
Mammalia Klhl11 35
  • 89.6 (n)
  • 96.97 (a)
Klhl11 16
Klhl11 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Klhl11 35
  • 89.21 (n)
  • 96.97 (a)
(Monodelphis domestica)
Mammalia KLHL11 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL11 36
  • 83 (a)
(Pan troglodytes)
Mammalia KLHL11 36
  • 100 (a)
(Gallus gallus)
Aves KLHL11 35
  • 75.77 (n)
  • 84.37 (a)
KLHL11 36
  • 81 (a)
(Anolis carolinensis)
Reptilia KLHL11 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl11 35
  • 68.86 (n)
  • 76.61 (a)
(Danio rerio)
Actinopterygii klhl11 35
  • 68.83 (n)
  • 74.54 (a)
wufd21e01 35
klhl11 36
  • 69 (a)
Species with no ortholog for KLHL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL11 Gene

Gene Tree for KLHL11 (if available)
Gene Tree for KLHL11 (if available)

Paralogs for KLHL11 Gene

Paralogs for KLHL11 Gene

genes like me logo Genes that share paralogs with KLHL11: view

Variants for KLHL11 Gene

Sequence variations from dbSNP and Humsavar for KLHL11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2883068 -- 41,863,519(+) CACAG(A/C)ACTAT intron-variant
rs4031019 -- 41,863,345(+) ggcac(A/G)ccacc intron-variant
rs4516280 -- 41,864,249(+) taaat(C/G)AGCTA intron-variant
rs4796617 -- 41,862,060(+) TCTAC(A/G)TTTCC intron-variant
rs4796723 -- 41,855,797(+) ctccc(A/G)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL11 Gene

Variant ID Type Subtype PubMed ID
nsv833447 CNV Loss 17160897
nsv908238 CNV Loss 21882294
dgv456e201 CNV Deletion 23290073
esv2715943 CNV Deletion 23290073

Relevant External Links for KLHL11 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL11 Gene

Disorders for KLHL11 Gene

No disorders were found for KLHL11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KLHL11 Gene

Publications for KLHL11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PMID: 23349464) Canning P. … Bullock A.N. (J. Biol. Chem. 2013) 3 4
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  5. Large-scale analysis of lysine SUMOylation by SUMO remnant immunoaffinity profiling. (PMID: 25391492) Lamoliatte F. … Thibault P. (Nat Commun 2014) 3

Products for KLHL11 Gene

Sources for KLHL11 Gene

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