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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHL11 Gene

protein-coding   GIFtS: 44
GCID: GC17M040009

Kelch-Like Family Member 11

(Previous name: kelch-like 11 (Drosophila))
  Search for KLHL11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kelch-Like Family Member 111 2
Kelch-Like 11 (Drosophila)1
Kelch-Like 112
Kelch-Like Protein 112

External Ids:    HGNC: 190081   Entrez Gene: 551752   Ensembl: ENSG000001785027   UniProtKB: Q9NVR03   

Export aliases for KLHL11 gene to outside databases

Previous GC identifers: GC00U991260 GC17M040383 GC17M037263 GC17M040004 GC17M035772


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLHL11 Gene: 
KLHL11 (kelch-like family member 11) is a protein-coding gene. An important paralog of this gene is CCIN.

UniProtKB/Swiss-Prot: KLH11_HUMAN, Q9NVR0
Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates
the ubiquitination of target proteins, leading most often to their proteasomal degradation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHL11 gene promoter:
         Max1   STAT5B   NF-1   SREBP-1c   MyoD   SREBP-1b   N-Myc   SREBP-1a   GATA-6   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL11 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHL11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

KLHL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040009:  view genomic region     (about GC identifiers)

Start:
40,009,797 bp from pter      End:
40,021,684 bp from pter
Size:
11,888 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003571052 140,189-152,018     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLH11_HUMAN, Q9NVR0 (See protein sequence)
Recommended Name: Kelch-like protein 11 precursor  
Size: 708 amino acids; 80148 Da
Subunit: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity).
Homodimer. Interacts with CUL3
3 PDB 3D structures from and Proteopedia for KLHL11:
3I3N (3D)        4AP2 (3D)        4APF (3D)    

Explore the universe of human proteins at neXtProt for KLHL11: NX_Q9NVR0

Explore proteomics data for KLHL11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVR0

  • KLHL11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLHL11 Protein Expression
    REFSEQ proteins: NP_060613.1  
    ENSEMBL proteins: 
     ENSP00000314608  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    5/6 InterPro protein domains (see all 6):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ
     IPR011705 BACK
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q9NVR0

    ProtoNet protein and cluster: Q9NVR0

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH11_HUMAN, Q9NVR0
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 Kelch repeats


    KLHL11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH11_HUMAN, Q9NVR0
    Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates
    the ubiquitination of target proteins, leading most often to their proteasomal degradation (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KLHL11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL11:
     Increased cell death in HCT116 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL11

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL11

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/8 Interacting proteins for KLHL11 (Q9NVR03 ENSP000003146084) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    ENSG00000235712P287023I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHL11 (KLH11)

    Search CenterWatch for drugs/clinical trials and news about KLHL11 / KLH11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHL11 gene: 
    NM_018143.1  

    Unigene Cluster for KLHL11:

    Kelch-like family member 11
    Hs.592134  [show with all ESTs]
    Unigene Representative Sequence: BC034470
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000319121(uc002hyf.1)
    miRNA
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    Inhib. RNA
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    Primer
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    Additional mRNA sequence: 

    AK001434.1 AK301952.1 BC034470.1 

    2 DOTS entries:

    DT.317660  DT.100743163 

    24/125 AceView cDNA sequences (see all 125):

    NM_018143 BM718756 AK001434 BX092160 T92836 AA461516 BM698378 BG740359 
    AA460589 BX409825 BU933013 BQ422825 AI333913 BG719371 BI463857 AA126855 
    BM471751 AK096415 BM967256 AW673239 AW516406 Z39316 BM796357 AI474432 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHL11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCATTTTGT
    KLHL11 Expression
    About this image


    See KLHL11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHL11

    SOURCE GeneReport for Unigene cluster: Hs.592134
        SABiosciences Custom PCR Arrays for KLHL11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL11 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl111 , 5 kelch-like 11 (Drosophila)1, 5 89.41(n)1
    96.75(a)1
      11 (63.47 cM)5
    2171941  NM_172565.21  NP_766153.11 
     1004626145 
    chicken
    (Gallus gallus)
    Aves KLHL111 kelch-like 11 (Drosophila) 75.77(n)
    84.37(a)
      428313  XM_003642822.1  XP_003642870.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL116
    Uncharacterized protein
    78(a)
    1 ↔ 1
    6(66556686-66560645)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480126402   -- 78.02(n)    48012640 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd21e012 wufd21e01 75.4(n)   327313  BC045881.1 


    ENSEMBL Gene Tree for KLHL11 (if available)
    TreeFam Gene Tree for KLHL11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHL11 gene
    CCIN2  

    KLHL11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/307 SNPs in KLHL11 are shown (see all 307)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465489691,2
    --35771286(+) CCAACG/TACCGT 1 -- ds50010--------
    rs1839288001,2
    --35771334(+) CTAATA/GAAAAA 1 -- ds50010--------
    rs1876771141,2
    --35771379(+) TCATCA/GGTCAC 1 -- ds50010--------
    rs65036721,2
    C,F,A,H--35771658(+) GGAGTT/CATAAC 1 -- ds500125Minor allele frequency- C:0.24NS EA NA WA CSA 2354
    rs793138801,2
    C,F--35771918(+) CTTCAC/TGAAAC 1 -- ut313Minor allele frequency- T:0.04NA EA EU 1563
    rs174988751,2
    C,F,H--35771923(+) CGAAAC/TGGGTG 1 -- ut31 ese318Minor allele frequency- T:0.05NA NS EA WA EU 3353
    rs1412722021,2
    C--35771947(+) CGGCAA/C/TGCTTG 2 -- ut310--------
    rs1461391231,2
    C,F--35771997(+) TCATGT/CTCAGG 2 /N /S mis12Minor allele frequency- C:0.00NA EU 5873
    rs346847771,2
    C,F--35772038(+) ATGCGG/ATCCTT 2 /D syn13Minor allele frequency- A:0.01NA EU 5949
    rs1422878391,2
    C,F--35772107(+) GGGATC/TCTCAC 2 R syn11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for KLHL11 (40009797 - 40021684 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLHL11:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715943CNV Deletion23290073
    dgv456e201CNV Deletion23290073
    nsv833447CNV Loss17160897
    nsv908238CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHL11 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with KLHL11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PubMed id 23349464)1, 2 Canning P.... Bullock A.N. (2013)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    5. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55175 HGNC: 19008 AceView: KLHL11 Ensembl:ENSG00000178502 euGenes: HUgn55175
    ECgene: KLHL11 H-InvDB: KLHL11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHL11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHL11 gene:
    Search GeneIP for patents involving KLHL11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Proteins for KLHL11
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL11
     SwitchGear 3'UTR luciferase reporter plasmids for KLHL11
     SwitchGear Promoter luciferase reporter plasmids for KLHL11
     ThermoFisher Antibody for KLHL11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL11
     inGenious Targeting Laboratory - Custom generated mouse model solutions for KLHL11
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLHL11
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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