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Aliases for KLHL11 Gene

Aliases for KLHL11 Gene

  • Kelch Like Family Member 11 2 3 5
  • Kelch-Like 11 (Drosophila) 2

External Ids for KLHL11 Gene

Previous GeneCards Identifiers for KLHL11 Gene

  • GC00U991260
  • GC17M040383
  • GC17M037263
  • GC17M040004
  • GC17M035772
  • GC17M040009

Summaries for KLHL11 Gene

GeneCards Summary for KLHL11 Gene

KLHL11 (Kelch Like Family Member 11) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is CCIN.

UniProtKB/Swiss-Prot for KLHL11 Gene

  • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL11 Gene

Genomics for KLHL11 Gene

Regulatory Elements for KLHL11 Gene

Enhancers for KLHL11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G041798 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +64.9 64930 3.5 HDGF ARID4B SIN3A ZNF2 SLC30A9 ZNF143 DEK PAF1 ZNF263 SP3 JUP NT5C3B KLHL11 KLHL10 CNP TTC25 KRT19 KRT17 KRT15 KRT16
GH17G041791 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +71.2 71227 5.1 HDGF PKNOX1 FOXA2 MLX ARNT SIN3A ARID4B YY1 ZNF766 FOS JUP NT5C3B KLHL11 KRT15 ENSG00000267632 TUBG2 ACLY KRT19 KRT16 KRT17
GH17G041687 1.7 Ensembl ENCODE dbSUPER 10.2 +175.0 175033 6.1 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 CNTNAP1 ENSG00000267758 ENSG00000259623 KLHL10 TMEM99 HSD17B1P1 HAP1 TUBG2 CCR10 HSD17B1
GH17G041959 1.6 Ensembl ENCODE dbSUPER 10.7 -94.4 -94448 1.7 HDGF PKNOX1 CREB3L1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 SLC30A9 NT5C3B LOC108783654 ENSG00000267758 KLHL11 CNP GC17M041929
GH17G041956 1.5 Ensembl ENCODE dbSUPER 10.9 -92.1 -92130 1.8 HDGF ATF1 MLX ZFP64 ARID4B DMAP1 SLC30A9 GATA2 ZNF207 PPARG NT5C3B KLHL11 CNP GC17M041929
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHL11 on UCSC Golden Path with GeneCards custom track

Promoters for KLHL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000094300 431 1601 HDGF HNRNPUL1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for KLHL11 Gene

Chromosome:
17
Start:
41,848,518 bp from pter
End:
41,865,431 bp from pter
Size:
16,914 bases
Orientation:
Minus strand

Genomic View for KLHL11 Gene

Genes around KLHL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL11 Gene

Proteins for KLHL11 Gene

  • Protein details for KLHL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVR0-KLH11_HUMAN
    Recommended name:
    Kelch-like protein 11
    Protein Accession:
    Q9NVR0

    Protein attributes for KLHL11 Gene

    Size:
    708 amino acids
    Molecular mass:
    80148 Da
    Quaternary structure:
    • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer. Interacts with CUL3.

    Three dimensional structures from OCA and Proteopedia for KLHL11 Gene

neXtProt entry for KLHL11 Gene

Post-translational modifications for KLHL11 Gene

  • Ubiquitination at isoforms=298, posLast=454454, posLast=469469, posLast=480480, isoforms=489, isoforms=521, and posLast=682682
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL11 Gene

Domains & Families for KLHL11 Gene

Gene Families for KLHL11 Gene

Suggested Antigen Peptide Sequences for KLHL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHL11: view

No data available for UniProtKB/Swiss-Prot for KLHL11 Gene

Function for KLHL11 Gene

Molecular function for KLHL11 Gene

UniProtKB/Swiss-Prot Function:
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Gene Ontology (GO) - Molecular Function for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with KLHL11: view
genes like me logo Genes that share phenotypes with KLHL11: view

Animal Model Products

CRISPR Products

miRNA for KLHL11 Gene

miRTarBase miRNAs that target KLHL11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL11 Gene

Localization for KLHL11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHL11 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0019005 SCF ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHL11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHL11 Gene

Pathways & Interactions for KLHL11 Gene

genes like me logo Genes that share pathways with KLHL11: view

Gene Ontology (GO) - Biological Process for KLHL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030162 regulation of proteolysis IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with KLHL11: view

No data available for SIGNOR curated interactions for KLHL11 Gene

Transcripts for KLHL11 Gene

mRNA/cDNA for KLHL11 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL11 Gene

Kelch-like family member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL11 Gene

No ASD Table

Relevant External Links for KLHL11 Gene

GeneLoc Exon Structure for
KLHL11
ECgene alternative splicing isoforms for
KLHL11

Expression for KLHL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHL11 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL11 Gene

This gene is overexpressed in Testis (x6.4).

Protein differential expression in normal tissues from HIPED for KLHL11 Gene

This gene is overexpressed in Pancreatic juice (29.6), Platelet (11.3), and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLHL11 Gene



Protein tissue co-expression partners for KLHL11 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLHL11 Gene:

KLHL11

SOURCE GeneReport for Unigene cluster for KLHL11 Gene:

Hs.592134
genes like me logo Genes that share expression patterns with KLHL11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHL11 Gene

Orthologs for KLHL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHL11 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL11 34 35
  • 93.13 (n)
cow
(Bos Taurus)
Mammalia KLHL11 34 35
  • 91.57 (n)
mouse
(Mus musculus)
Mammalia Klhl11 34 16 35
  • 89.6 (n)
rat
(Rattus norvegicus)
Mammalia Klhl11 34
  • 89.21 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHL11 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL11 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL11 34 35
  • 75.77 (n)
lizard
(Anolis carolinensis)
Reptilia KLHL11 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl11 34
  • 68.86 (n)
zebrafish
(Danio rerio)
Actinopterygii klhl11 34 35
  • 68.83 (n)
wufd21e01 34
Species where no ortholog for KLHL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL11 Gene

ENSEMBL:
Gene Tree for KLHL11 (if available)
TreeFam:
Gene Tree for KLHL11 (if available)

Paralogs for KLHL11 Gene

Paralogs for KLHL11 Gene

genes like me logo Genes that share paralogs with KLHL11: view

Variants for KLHL11 Gene

Sequence variations from dbSNP and Humsavar for KLHL11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000043828 -- 41,864,776(+) GCATC(C/T)CCCCC intron-variant
rs1000049906 -- 41,861,591(+) TGAGG(C/G)AGGAA intron-variant
rs1000142918 -- 41,861,373(+) CTTTT(C/T)TCTGT intron-variant
rs1000251684 -- 41,854,632(+) ATCCA(A/G)CAACA nc-transcript-variant, reference, missense
rs1000512178 -- 41,866,479(+) CTCCC(A/G)AAGTG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLHL11 Gene

Variant ID Type Subtype PubMed ID
dgv415e201 CNV deletion 23290073
esv2715943 CNV deletion 23290073
esv3640596 CNV loss 21293372
nsv1057008 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv833447 CNV loss 17160897

Variation tolerance for KLHL11 Gene

Residual Variation Intolerance Score: 9.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL11 Gene

Disorders for KLHL11 Gene

Relevant External Links for KLHL11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL11

No disorders were found for KLHL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL11 Gene

Publications for KLHL11 Gene

  1. Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PMID: 23349464) Canning P. … Bullock A.N. (J. Biol. Chem. 2013) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 64

Products for KLHL11 Gene

Sources for KLHL11 Gene

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