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KLHL11 Gene

protein-coding   GIFtS: 46
GCID: GC17M040009

Kelch-Like Family Member 11

(Previous name: kelch-like 11 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 111 2
Kelch-Like 11 (Drosophila)1
Kelch-Like 112
Kelch-Like Protein 112

External Ids:    HGNC: 190081   Entrez Gene: 551752   Ensembl: ENSG000001785027   UniProtKB: Q9NVR03   

Export aliases for KLHL11 gene to outside databases

Previous GC identifers: GC00U991260 GC17M040383 GC17M037263 GC17M040004 GC17M035772


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL11 Gene:
KLHL11 (kelch-like family member 11) is a protein-coding gene. An important paralog of this gene is CCIN.

UniProtKB/Swiss-Prot: KLH11_HUMAN, Q9NVR0
Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates
the ubiquitination of target proteins, leading most often to their proteasomal degradation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL11 gene promoter:
         Max1   STAT5B   NF-1   SREBP-1c   MyoD   SREBP-1b   N-Myc   SREBP-1a   GATA-6   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL11 promoter sequence
   Search Chromatin IP Primers for KLHL11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21

KLHL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL11 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M040009:  view genomic region     (about GC identifiers)

Start:
40,009,797 bp from pter      End:
40,021,684 bp from pter
Size:
11,888 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003571052 140,189-152,018     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLH11_HUMAN, Q9NVR0 (See protein sequence)
Recommended Name: Kelch-like protein 11 precursor  
Size: 708 amino acids; 80148 Da
Subunit: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity).
Homodimer. Interacts with CUL3
3 PDB 3D structures from and Proteopedia for KLHL11:
3I3N (3D)        4AP2 (3D)        4APF (3D)    

Explore the universe of human proteins at neXtProt for KLHL11: NX_Q9NVR0

Explore proteomics data for KLHL11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys298, Lys454, Lys469, Lys480, Lys489, Lys521, Lys682
  • Modification sites at PhosphoSitePlus

  • See KLHL11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060613.1  
    ENSEMBL proteins: 
     ENSP00000314608  

    KLHL11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for KLHL11

     
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    antibodies-online proteins for KLHL11 (4 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    KLHL: Kelch-like

    Selected InterPro protein domains (see all 6):
     IPR006652 Kelch_1
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ
     IPR011705 BACK
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q9NVR0

    ProtoNet protein and cluster: Q9NVR0

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB011705 BTB/Kelch-associated


    UniProtKB/Swiss-Prot: KLH11_HUMAN, Q9NVR0
    Similarity: Contains 1 BACK (BTB/Kelch associated) domain
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 Kelch repeats


    Find genes that share domains with KLHL11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLH11_HUMAN, Q9NVR0
    Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates
    the ubiquitination of target proteins, leading most often to their proteasomal degradation (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KLHL11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHL11:
     Increased cell death in HCT116 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KLHL11

    miRNA
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    miRTarBase miRNAs that target KLHL11:
    hsa-mir-335-5p (MIRT018273), hsa-let-7b-5p (MIRT052056), hsa-mir-92a-3p (MIRT049484), hsa-mir-615-3p (MIRT040230)

    Block miRNA regulation of human, mouse, rat KLHL11 using miScript Target Protectors
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    Addgene plasmids for KLHL11 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    endoplasmic reticulum1
    lysosome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL11
    Interactions:

        Search GeneGlobe Interaction Network for KLHL11

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for KLHL11 (Q9NVR03 ENSP000003146084) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    ENSG00000235712P287023I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHL11 (KLH11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLHL11 gene: 
    NM_018143.1  

    Unigene Cluster for KLHL11:

    Kelch-like family member 11
    Hs.592134  [show with all ESTs]
    Unigene Representative Sequence: BC034470
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000319121(uc002hyf.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat KLHL11

    Additional mRNA sequence: 

    AK001434.1 AK301952.1 BC034470.1 

    2 DOTS entries:

    DT.317660  DT.100743163 

    Selected AceView cDNA sequences (see all 125):

    T92836 NM_018143 BG740359 BX092160 AA461516 AK001434 AA460589 BM698378 
    BM718756 BM967256 BM477711 BU728591 AI474432 AL157681 BU933013 AA017177 
    BX496527 AW970177 AI742257 AL704740 H85851 AI278190 AW673239 Z39316 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLHL11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCATTTTGT
    KLHL11 Expression
    About this image

    KLHL11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHL11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592134
        Custom PCR Arrays for KLHL11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLHL11 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhl111 , 5 kelch-like 11 (Drosophila)5
    kelch-like 111
    89.6(n)1
    96.97(a)1
      11 (63.47 cM)5
    2171941  NM_172565.21  NP_766153.11 
     1004626145 
    chicken
    (Gallus gallus)
    Aves KLHL111 kelch-like 11 (Drosophila) 75.77(n)
    84.37(a)
      428313  XM_003642822.2  XP_003642870.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHL116
    kelch-like family member 11
    78(a)
    1 ↔ 1
    6(66556686-66560645)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480126402   -- 78.02(n)    48012640 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd21e012 wufd21e01 75.4(n)   327313  BC045881.1 


    ENSEMBL Gene Tree for KLHL11 (if available)
    TreeFam Gene Tree for KLHL11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLHL11 gene
    CCIN2  

    Find genes that share paralogs with KLHL11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLHL11 (see all 307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465489691,2
    --35771286(+) CCAACG/TACCGT 1 -- ds50010--------
    rs1839288001,2
    --35771334(+) CTAATA/GAAAAA 1 -- ds50010--------
    rs1876771141,2
    --35771379(+) TCATCA/GGTCAC 1 -- ds50010--------
    rs65036721,2
    C,F,A,H--35771658(+) GGAGTT/CATAAC 1 -- ds500125Minor allele frequency- C:0.24NS EA NA WA CSA 2354
    rs793138801,2
    C,F--35771918(+) CTTCAC/TGAAAC 1 -- ut313Minor allele frequency- T:0.04NA EA EU 1563
    rs174988751,2
    C,F,H--35771923(+) CGAAAC/TGGGTG 1 -- ut31 ese318Minor allele frequency- T:0.05NA NS EA WA EU 3353
    rs1412722021,2
    C--35771947(+) CGGCAA/C/TGCTTG 2 -- ut310--------
    rs1461391231,2
    C,F--35771997(+) TCATGT/CTCAGG 2 /N /S mis12Minor allele frequency- C:0.00NA EU 5873
    rs346847771,2
    C,F--35772038(+) ATGCGG/ATCCTT 2 /D syn13Minor allele frequency- A:0.01NA EU 5949
    rs1422878391,2
    C,F--35772107(+) GGGATC/TCTCAC 2 R syn11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for KLHL11 (40009797 - 40021684 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLHL11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715943CNV Deletion23290073
    dgv456e201CNV Deletion23290073
    nsv833447CNV Loss17160897
    nsv908238CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHL11
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHL11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL11 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with KLHL11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PubMed id 23349464)1, 2 Canning P.... Bullock A.N. (J. Biol. Chem. 2013)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55175 HGNC: 19008 AceView: KLHL11 Ensembl:ENSG00000178502 euGenes: HUgn55175
    ECgene: KLHL11 H-InvDB: KLHL11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLHL11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL11 gene:
    Search GeneIP for patents involving KLHL11

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLHL11  
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     Block miRNA regulation of human, mouse, rat KLHL11 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLHL11
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL11 Predesigned siRNA for gene silencing in human, mouse, rat KLHL11
     QuantiFast Probe-based Assays in human, mouse, rat KLHL11 QuantiTect SYBR Green Assays in human, mouse, rat KLHL11
     Custom PCR Arrays for KLHL11 Search Chromatin IP Primers for KLHL11
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for KLHL11
     Gene Synthesis
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     SwitchGear 3'UTR luciferase reporter plasmids for KLHL11
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL11
     Browse compounds at ApexBio
     Addgene plasmids for KLHL11
      Search eBioscience for proteins for KLHL11
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     genOway: Develop your customized and physiologically relevant rodent model for KLHL11
     antibodies-online antibodies for KLHL11 (26 products)
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      Search antibodies-online for peptides for KLHL11
     antibodies-online proteins for KLHL11 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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