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Aliases for KLHL11 Gene

Aliases for KLHL11 Gene

  • Kelch Like Family Member 11 2 3 5
  • Kelch-Like 11 (Drosophila) 2

External Ids for KLHL11 Gene

Previous GeneCards Identifiers for KLHL11 Gene

  • GC00U991260
  • GC17M040383
  • GC17M037263
  • GC17M040004
  • GC17M035772
  • GC17M040009

Summaries for KLHL11 Gene

GeneCards Summary for KLHL11 Gene

KLHL11 (Kelch Like Family Member 11) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is CCIN.

UniProtKB/Swiss-Prot for KLHL11 Gene

  • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL11 Gene

Genomics for KLHL11 Gene

Regulatory Elements for KLHL11 Gene

Promoters for KLHL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHL11 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHL11 Gene

Chromosome:
17
Start:
41,848,518 bp from pter
End:
41,865,431 bp from pter
Size:
16,914 bases
Orientation:
Minus strand

Genomic View for KLHL11 Gene

Genes around KLHL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL11 Gene

Proteins for KLHL11 Gene

  • Protein details for KLHL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVR0-KLH11_HUMAN
    Recommended name:
    Kelch-like protein 11
    Protein Accession:
    Q9NVR0

    Protein attributes for KLHL11 Gene

    Size:
    708 amino acids
    Molecular mass:
    80148 Da
    Quaternary structure:
    • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer. Interacts with CUL3.

    Three dimensional structures from OCA and Proteopedia for KLHL11 Gene

neXtProt entry for KLHL11 Gene

Proteomics data for KLHL11 Gene at MOPED

Post-translational modifications for KLHL11 Gene

  • Ubiquitination at Lys 298, Lys 454, Lys 469, Lys 480, Lys 489, Lys 521, and Lys 682
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL11 Gene

Domains & Families for KLHL11 Gene

Gene Families for KLHL11 Gene

Protein Domains for KLHL11 Gene

Suggested Antigen Peptide Sequences for KLHL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVR0

UniProtKB/Swiss-Prot:

KLH11_HUMAN :
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 5 Kelch repeats.
Domain:
  • Contains 1 BACK (BTB/Kelch associated) domain.
  • Contains 1 BTB (POZ) domain.
Similarity:
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KLHL11: view

Function for KLHL11 Gene

Molecular function for KLHL11 Gene

UniProtKB/Swiss-Prot Function:
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
genes like me logo Genes that share phenotypes with KLHL11: view

Animal Model Products

miRNA for KLHL11 Gene

miRTarBase miRNAs that target KLHL11

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHL11 Gene

Localization for KLHL11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHL11 Gene COMPARTMENTS Subcellular localization image for KLHL11 gene
Compartment Confidence
cytosol 2
extracellular 2
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHL11 Gene

Pathways & Interactions for KLHL11 Gene

genes like me logo Genes that share pathways with KLHL11: view

Interacting Proteins for KLHL11 Gene

Gene Ontology (GO) - Biological Process for KLHL11 Gene

None

No data available for SIGNOR curated interactions for KLHL11 Gene

Drugs & Compounds for KLHL11 Gene

No Compound Related Data Available

Transcripts for KLHL11 Gene

mRNA/cDNA for KLHL11 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(125) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHL11 Gene

Kelch-like family member 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL11 Gene

No ASD Table

Relevant External Links for KLHL11 Gene

GeneLoc Exon Structure for
KLHL11
ECgene alternative splicing isoforms for
KLHL11

Expression for KLHL11 Gene

mRNA expression in normal human tissues for KLHL11 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL11 Gene

This gene is overexpressed in Testis (x6.4).

Protein differential expression in normal tissues from HIPED for KLHL11 Gene

This gene is overexpressed in Pancreatic juice (29.6), Platelet (11.3), and Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHL11 Gene



SOURCE GeneReport for Unigene cluster for KLHL11 Gene Hs.592134

genes like me logo Genes that share expression patterns with KLHL11: view

Protein tissue co-expression partners for KLHL11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL11 Gene

Orthologs for KLHL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHL11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHL11 35
  • 91.57 (n)
  • 99.15 (a)
KLHL11 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHL11 35
  • 93.13 (n)
  • 99.44 (a)
KLHL11 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhl11 35
  • 89.6 (n)
  • 96.97 (a)
Klhl11 16
Klhl11 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhl11 35
  • 89.21 (n)
  • 96.97 (a)
oppossum
(Monodelphis domestica)
Mammalia KLHL11 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHL11 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHL11 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHL11 35
  • 75.77 (n)
  • 84.37 (a)
KLHL11 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHL11 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl11 35
  • 68.86 (n)
  • 76.61 (a)
zebrafish
(Danio rerio)
Actinopterygii klhl11 35
  • 68.83 (n)
  • 74.54 (a)
wufd21e01 35
klhl11 36
  • 69 (a)
OneToOne
Species with no ortholog for KLHL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL11 Gene

ENSEMBL:
Gene Tree for KLHL11 (if available)
TreeFam:
Gene Tree for KLHL11 (if available)

Paralogs for KLHL11 Gene

Paralogs for KLHL11 Gene

genes like me logo Genes that share paralogs with KLHL11: view

Variants for KLHL11 Gene

Sequence variations from dbSNP and Humsavar for KLHL11 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2883068 -- 41,863,519(+) CACAG(A/C)ACTAT intron-variant
rs4031019 -- 41,863,345(+) ggcac(A/G)ccacc intron-variant
rs3744782 -- 41,854,727(-) GGATA(C/T)TTTGT reference, synonymous-codon
rs4516280 -- 41,864,249(+) taaat(C/G/T)AGCTA intron-variant
rs5004986 -- 41,852,602(+) CCTGG(G/T)CAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHL11 Gene

Variant ID Type Subtype PubMed ID
nsv833447 CNV Loss 17160897
nsv908238 CNV Loss 21882294
dgv456e201 CNV Deletion 23290073
esv2715943 CNV Deletion 23290073

Variation tolerance for KLHL11 Gene

Residual Variation Intolerance Score: 9.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHL11 Gene

HapMap Linkage Disequilibrium report
KLHL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL11 Gene

Disorders for KLHL11 Gene

Relevant External Links for KLHL11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHL11

No disorders were found for KLHL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHL11 Gene

Publications for KLHL11 Gene

  1. Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases. (PMID: 23349464) Canning P. … Bullock A.N. (J. Biol. Chem. 2013) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  4. Update on the Kelch-like (KLHL) gene family. (PMID: 23676014) Dhanoa B.S. … Friedman J.S. (Hum. Genomics 2013) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for KLHL11 Gene

Sources for KLHL11 Gene

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