KLHL11 Gene
protein-coding GIFtS: 43
GCID: GC17M040009
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kelch-like family member 11(Previous name: kelch-like 11 (Drosophila) )
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Aliases
for KLHL11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 111 2 | | FLJ105721 | | Kelch-Like 11 (Drosophila)1 | | Kelch-Like 112 | | Kelch-Like Protein 112 |
Export aliases for KLHL11 gene to outside databasesPrevious GC identifers: GC00U991260 GC17M040383 GC17M037263 GC17M040004 GC17M035772 |
Summaries
for KLHL11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLHL11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL11 gene promoter:
Max1 STAT5B NF-1 SREBP-1c MyoD SREBP-1b N-Myc SREBP-1a GATA-6 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21KLHL11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M040009: view genomic region
(about GC identifiers)
Start:
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40,009,797 bp from pter |
End:
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40,021,684 bp from pter |
Size:
|
11,888 bases |
Orientation:
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minus strand |
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Proteins
for KLHL11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLH11_HUMAN, Q9NVR0 (See
protein sequence)Recommended Name: Kelch-like protein 11 precursor Size: 708 amino acids; 80148 Da
Subcellular location: Secreted (Potential)
3 PDB 3D structures from  and Proteopedia  for KLHL11:3I3N (3D)
4AP2 (3D)
4APF (3D)
Explore the universe of human proteins at neXtProt for KLHL11: NX_Q9NVR0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NVR0
KLHL11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060613.1
ENSEMBL proteins: ENSP00000314608
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
KLHL11 for ontologies About GeneDecksing
KLHL11 Antibody Products:
Assay Products for KLHL11: |
Protein
Domains /
Families
for KLHL11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHL11 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9NVR0ProtoNet protein and cluster: Q9NVR0 2 Blocks protein families: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KLH11_HUMAN, Q9NVR0Similarity: Contains 1 BACK (BTB/Kelch associated) domainSimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 5 Kelch repeats |
Function
for KLHL11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for KLHL11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL11 |
1 GenomeRNAi human phenotype for KLHL11:
|
Pathways & Interactions
for KLHL11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL11
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for KLHL11 (Q9NVR03 ENSP000003146084) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KLHL11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL11
Search CenterWatch for drugs/clinical trials and news about KLHL11 / KLH11
|
Transcripts
for KLHL11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL11 gene: NM_018143.1 Unigene Cluster for KLHL11: Kelch-like 11 (Drosophila) Hs.592134 [show with all ESTs]Unigene Representative Sequence: BC0344701 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000319121(uc002hyf.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHL11 (NM_018143) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL11 |
Additional cDNA sequence: AK001434.1 AK301952.1 BC034470.1 2 DOTS entries: DT.317660 DT.100743163 24/125 AceView cDNA sequences (see all 125): T92836 BM698378 AK001434 AA461516 BX092160 BG740359 NM_018143 AA460589 BM718756 CK823381 AL157681 BC040976 AL704740 BM967043 AW015346 CB143699 BM796357 AA126852 BU728591 BC034470 AW516406 BU742400 AI474432 AI333913
GeneLoc Exon Structure
|
Expression
for KLHL11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCATTTTGT
About this image
See KLHL11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL11
SOURCE GeneReport for Unigene cluster: Hs.592134
SABiosciences Custom PCR Arrays for KLHL11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL11 |
Orthologs
for KLHL11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for KLHL11 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KLHL111 |
kelch-like 11 (Drosophila) |
75.77(n)
84.37(a) |
|
428313 XM_003642822.1 XP_003642870.1 |
lizard
(Anolis carolinensis) |
Reptilia |
KLHL116 |
-- |
78(a) |
1 ↔ 1 |
6(66556686-66560645) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480126402 |
-- |
78.02(n) |
|
48012640 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufd21e012 |
wufd21e01 |
75.4(n) |
|
327313 BC045881.1 |
ENSEMBL Gene Tree for KLHL11 (if available)
TreeFam Gene Tree for KLHL11 (if available) |
Paralogs
for KLHL11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL11 gene
- KLHL382 KLHL212 KLHL292 KLHL62 KLHL232 KBTBD32 KLHL242 KLHL252
- KLHL302 KLHL352 ENC12 CCIN2
KLHL11 for paralogs About GeneDecksing
|
Genomic Variants
for KLHL11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHL11 (40009797 - 40021684 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLHL11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL11 |
|
Disorders
/ Diseases
for KLHL11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KLHL11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHL11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KLHL11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing KLHL11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHL11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLHL11 gene:
Search GeneIP for patents involving KLHL11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLHL11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL11 | | | OriGene Protein Over-expression Lysate for KLHL11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLHL11 | | OriGene 3'-UTR Clone for KLHL11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KLHL11 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL11 |
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| |  |  |  |  | | | | |
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 | | | KLHL11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL11 |
|  |  |  | | | | ThermoFisher Antibody for KLHL11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL11 |
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