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KLHL10 Gene

protein-coding   GIFtS: 48
GCID: GC17P039992

Kelch-Like Family Member 10

(Previous name: kelch-like 10 (Drosophila))
  See KLHL10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 101 2
SPGF112 5
Kelch-Like 10 (Drosophila)1
Kelch-Like 102
Kelch-Like Protein 102

External Ids:    HGNC: 188291   Entrez Gene: 3177192   Ensembl: ENSG000001615947   OMIM: 6087785   UniProtKB: Q6JEL23   

Export aliases for KLHL10 gene to outside databases

Previous GC identifers: GC17U900007 GC17P039902 GC17P040367 GC17P037248 GC17P035755


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLHL10 Gene:
KLHL10 (kelch-like family member 10) is a protein-coding gene. Diseases associated with KLHL10 include spermatogenic failure 11, and oligospermia. An important paralog of this gene is KLHL17.

UniProtKB/Swiss-Prot: KLH10_HUMAN, Q6JEL2
Function: May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates
the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL10 gene promoter:
         GR   USF1   RFX1   MIF-1   XBP-1   Cdc5   SRY   USF-1   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL10 promoter sequence
   Search Chromatin IP Primers for KLHL10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.2

KLHL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL10 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P039992:  view genomic region     (about GC identifiers)

Start:
39,991,937 bp from pter      End:
40,004,636 bp from pter
Size:
12,700 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003571052 124,433-134,989     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLH10_HUMAN, Q6JEL2 (See protein sequence)
Recommended Name: Kelch-like protein 10  
Size: 608 amino acids; 68942 Da
Subunit: Self-associates (Probable). Interacts with CUL3; indicative for the participation in an E3 ubiquitin
ligase complex (By similarity)
Sequence caution: Sequence=BAB71387.1; Type=Erroneous termination; Positions=609; Note=Translated as stop;
Secondary accessions: Q6NW28 Q96MC0

Explore the universe of human proteins at neXtProt for KLHL10: NX_Q6JEL2

Explore proteomics data for KLHL10 at MOPED


See KLHL10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689680.2  
ENSEMBL proteins: 
 ENSP00000391983   ENSP00000293303   ENSP00000416221  

KLHL10 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for KLHL10

 
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antibodies-online proteins for KLHL10 (4 products) 

 
antibodies-online peptides for KLHL10

KLHL10 Antibody Products:

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antibodies-online antibodies for KLHL10 (12 products) 

KLHL10 Assay Products:

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antibodies-online kits for KLHL10 (6 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
BTBD: BTB/POZ domain containing
KLHL: Kelch-like

Selected InterPro protein domains (see all 7):
 IPR006652 Kelch_1
 IPR011333 BTB/POZ_fold
 IPR017096 Kelch-like_gigaxonin-typ
 IPR015916 Gal_Oxidase_b-propeller
 IPR013069 BTB_POZ

Graphical View of Domain Structure for InterPro Entry Q6JEL2

ProtoNet protein and cluster: Q6JEL2

3 Blocks protein domains:
IPB000210 BTB/POZ domain
IPB006651 Kelch repeat signature
IPB011705 BTB/Kelch-associated


UniProtKB/Swiss-Prot: KLH10_HUMAN, Q6JEL2
Similarity: Contains 1 BTB (POZ) domain
Similarity: Contains 6 Kelch repeats


Find genes that share domains with KLHL10           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: KLH10_HUMAN, Q6JEL2
Function: May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates
the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with KLHL10           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for KLHL10:
 Decreased viability with pacli 

     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Klhl10):
 endocrine/exocrine gland  reproductive system 

Find genes that share phenotypes with KLHL10           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Klhl10tm1Zuk for KLHL10

   genOway: Develop your customized and physiologically relevant rodent model for KLHL10

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat KLHL10 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate KLHL10:
hsa-miR-137
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Inhib. RNA
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Gene Editing
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL10

Cell Line
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
KLH10_HUMAN, Q6JEL2: Cytoplasm (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--

Find genes that share ontologies with KLHL10           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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UniProtKB/Swiss-Prot: KLH10_HUMAN, Q6JEL2
Pathway: Protein modification; protein ubiquitination

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL10
Interactions:

    Search GeneGlobe Interaction Network for KLHL10

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for KLHL10 (Q6JEL23 ENSP000002933034) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

InteractantInteraction Details
GeneCardExternal ID(s)
PIWIL1Q96J943I2D: score=1 
BIRC6ENSP000003935964STRING: ENSP00000393596
CUL3ENSP000002644144STRING: ENSP00000264414
CUL4AENSP000003645894STRING: ENSP00000364589
CUL4BENSP000003841094STRING: ENSP00000384109
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000902cell morphogenesis IEA--
GO:0007286spermatid development IEA--
GO:0008584male gonad development IEA--
GO:0009566fertilization IEA--
GO:0016567protein ubiquitination IEA--

Find genes that share ontologies with KLHL10           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for KLHL10 (KLH10)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for KLHL10 gene: 
NM_152467.3  

Unigene Cluster for KLHL10:

Kelch-like family member 10
Hs.127510  [show with all ESTs]
Unigene Representative Sequence: AY495339
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000448203 ENST00000293303(uc010cxr.3 uc010wfv.1 uc010wfw.2)
ENST00000438813 ENST00000485613
miRNA
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1 qRT-PCR Assays for microRNA that regulate KLHL10:
hsa-miR-137
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for KLHL10
Predesigned siRNA for gene silencing in human, mouse, rat KLHL10
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OriGene ORF clones in mouse, rat for KLHL10
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GenScript: all cDNA clones in your preferred vector: KLHL10 (NM_152467)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL10
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL10
  QuantiTect SYBR Green Assays in human, mouse, rat KLHL10
  QuantiFast Probe-based Assays in human, mouse, rat KLHL10

Additional mRNA sequence: 

AK301797.1 AK302141.1 AY495339.1 BC067753.1 

3 DOTS entries:

DT.99952125  DT.91666521  DT.120946473 

19 AceView cDNA sequences:

AA953988 AY495339 BG718980 NM_152467 BI550674 AK057224 BC067753 BM908026 
BP371679 AI187883 BP370284 AW003288 BM559877 BP371285 BI826055 BP370606 
BI459506 BI459761 AI126337 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KLHL10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGTATATACC
KLHL10 Expression
About this image

KLHL10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KLHL10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.127510
    Custom PCR Arrays for KLHL10
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for KLHL10
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL10
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for KLHL10 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Klhl101 , 5 kelch-like 10 (Drosophila)5
kelch-like 101
91.34(n)1
98.85(a)1
  11 (63.47 cM)5
667201  NM_025727.31  NP_080003.11 
 1004419175 
chicken
(Gallus gallus)
Aves KLHL101 kelch-like 10 (Drosophila) 75.34(n)
80.14(a)
  420033  NM_001277298.1  NP_001264227.1 
lizard
(Anolis carolinensis)
Reptilia KLHL106
kelch-like family member 10
88(a)
1 ↔ 1
GL344401.1(35039-44784)
tropical clawed frog
(Xenopus tropicalis)
Amphibia klhl101 kelch-like family member 10 62.67(n)
59.39(a)
  100486163  XM_002943925.2  XP_002943971.2 
zebrafish
(Danio rerio)
Actinopterygii LOC5604581 kelch-like protein 10-like 63.43(n)
58.16(a)
  560458  XM_683858.3  XP_688950.1 
fruit fly
(Drosophila melanogaster)
Insecta klhl101 klhl10 52.88(n)
46.83(a)
  3354863  NM_001015101.2  NP_001015101.2 


ENSEMBL Gene Tree for KLHL10 (if available)
TreeFam Gene Tree for KLHL10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KLHL10 gene
KLHL172  KLHL182  KLHL202  KLHL52  KLHL122  KEAP12  KLHL282  KLHL42  
KLHL32  KLHL82  KLHL12  KLHL22  
Selected SIMAP similar genes for KLHL10 using alignment to 3 protein entries:     KLH10_HUMAN (see all proteins) (see all similar genes):
ZBTB7C    ZBTB21    HIC1    ZBTB14    ZBTB38    KLHL28
KLHL2    KLHL12    KLHL26    ZBTB16    KLHL18    KLHL24
KLHL1    KLHL17    KLHL3    KLHL32    KLHL36    KLHL4

Find genes that share paralogs with KLHL10           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KLHL10 (see all 269)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0693584
Spermatogenic failure 11 (SPGF11)4--see VAR_0693582 A T mis40--------
VAR_0693574
Spermatogenic failure 11 (SPGF11)4--see VAR_0693572 Q P mis40--------
rs1818822161,2
--39994702(+) AGAGAG/TGGAGT 1 -- int10--------
rs1388959621,2
--39994855(+) AAGAGA/GCATGA 1 -- int10--------
rs80646181,2
C,F,H--39994879(+) CttttC/Ttctct 1 -- int1 trp37Minor allele frequency- T:0.21NA WA 14
rs590760481,2
C--39994908(+) TTTTT-/TCCTTT 1 -- int12Minor allele frequency- T:0.00NA CSA 4
rs1869686741,2
--39995003(+) TGGCGC/GCATCT 1 -- int10--------
rs1910098651,2
--39995010(+) ATCTCA/GGCTCA 1 -- int10--------
rs1818341231,2
C--39995275(+) GTCTCA/GCTTTG 1 -- int10--------
rs45131461,2
C,F,A,H--39995305(+) gtggcC/Gtgatc 1 -- int18Minor allele frequency- G:0.24NA WA CSA 17

HapMap Linkage Disequilibrium report for KLHL10 (39991937 - 40004636 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for KLHL10:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833447CNV Loss17160897
nsv908238CNV Loss21882294

Human Gene Mutation Database (HGMD): KLHL10
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing KLHL10
DNA2.0 Custom Variant and Variant Library Synthesis for KLHL10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608778   
OMIM disorders: 615081  
UniProtKB/Swiss-Prot: KLH10_HUMAN, Q6JEL2
  • Spermatogenic failure 11 (SPGF11) [MIM:615081]: An infertility disorder caused by spermatogenesis
    defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects.
    Oligozoospermia is usually observed in SPGF11 patients. In addition to oligozoospermia, teratozoospermia and
    moderate asthenozoospermia is observed in some cases. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 2 diseases for KLHL10:    
    About MalaCards
    spermatogenic failure 11    oligospermia


    Find genes that share disorders with KLHL10           About GenesLikeMe

    Genetic Association Database (GAD): KLHL10
    Human Genome Epidemiology (HuGE) Navigator: KLHL10 (1 document)

    Export disorders for KLHL10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLHL10 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KLHL10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. (PubMed id 15136734)1, 2, 9 Yan W.... Matzuk M.M. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. [Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. (PubMed id 20218307)1, 4 Qiu Q.M....Lu G.X. (Zhonghua Nan Ke Xue 2009)
    3. Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. (PubMed id 17047026)1, 2 Yatsenko A.N....Matzuk M.M. (Hum. Mol. Genet. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
    6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 317719 HGNC: 18829 AceView: KLHL10 Ensembl:ENSG00000161594 euGenes: HUgn317719
    ECgene: KLHL10 H-InvDB: KLHL10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLHL10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLHL10 gene:
    Search GeneIP for patents involving KLHL10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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