KLHL10 Gene
protein-coding GIFtS: 48
GCID: GC17P039992
|
|
kelch-like family member 10(Previous name: kelch-like 10 (Drosophila) )
| |
Aliases
for KLHL10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch-Like Family Member 101 2 | | FLJ326621 | | Kelch-Like 10 (Drosophila)1 | | Kelch-Like 102 | | Kelch-Like Protein 102 |
Export aliases for KLHL10 gene to outside databasesPrevious GC identifers: GC17U900007 GC17P039902 GC17P040367 GC17P037248 GC17P035755 |
Summaries
for KLHL10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLHL10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHL10 gene promoter:
GR USF1 RFX1 MIF-1 XBP-1 Cdc5 SRY USF-1 STAT3 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHL10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.2KLHL10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P039992: view genomic region
(about GC identifiers)
Start:
|
39,991,937 bp from pter |
End:
|
40,004,636 bp from pter |
Size:
|
12,700 bases |
Orientation:
|
plus strand |
|
Proteins
for KLHL10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLH10_HUMAN, Q6JEL2 (See
protein sequence)Recommended Name: Kelch-like protein 10 Size: 608 amino acids; 68942 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAB71387.1; Type=Erroneous termination; Positions=609; Note=Translated as stop;
Secondary accessions: Q6NW28 Q96MC0Explore the universe of human proteins at neXtProt for KLHL10: NX_Q6JEL2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6JEL2
KLHL10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689680.2
ENSEMBL proteins: ENSP00000391983 ENSP00000293303 ENSP00000416221
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
KLHL10 for ontologies About GeneDecksing
KLHL10 Antibody Products:
Assay Products for KLHL10: |
Protein
Domains /
Families
for KLHL10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHL10 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q6JEL2ProtoNet protein and cluster: Q6JEL2 3 Blocks protein families: IPB000210 BTB/POZ domain IPB006651 Kelch repeat signature IPB011705 BTB/Kelch-associated
UniProtKB/Swiss-Prot: KLH10_HUMAN, Q6JEL2Similarity: Contains 1 BTB (POZ) domainSimilarity: Contains 6 Kelch repeats |
Function
for KLHL10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLHL10 (NM_152467) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL10 |
1 GenomeRNAi human phenotype for KLHL10:
Animal Models:
Mouse knock-out Klhl10tm1Zuk for KLHL10
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Klhl10):
KLHL10 for phenotypes About GeneDecksing
|
Pathways & Interactions
for KLHL10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHL10
1 Interacting protein for KLHL10 (Q6JEL23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
KLHL10 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLHL10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHL10
Search CenterWatch for drugs/clinical trials and news about KLHL10 / KLH10
|
Transcripts
for KLHL10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHL10 gene: NM_152467.3 Unigene Cluster for KLHL10: Kelch-like 10 (Drosophila) Hs.127510 [show with all ESTs]Unigene Representative Sequence: AY4953394 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000448203 ENST00000293303(uc010cxr.3 uc010wfv.1 uc010wfw.2)
ENST00000438813 ENST00000485613
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL10
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHL10 (NM_152467) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHL10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL10 |
Additional cDNA sequence: AK301797.1 AK302141.1 AY495339.1 BC067753.1 3 DOTS entries: DT.99952125 DT.91666521 DT.120946473 19 AceView cDNA sequences: AA953988 AY495339 BC067753 BP371285 BP371679 BM908026 BI550674 BI826055 AW003288 AI187883 BM559877 NM_152467 BG718980 AK057224 BP370284 BP370606 BI459506 BI459761 AI126337
GeneLoc Exon Structure
|
Expression
for KLHL10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHL10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTATATACC
About this image
See KLHL10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHL10
SOURCE GeneReport for Unigene cluster: Hs.127510
SABiosciences Custom PCR Arrays for KLHL10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHL10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL10 |
Orthologs
for KLHL10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KLHL10 gene from 5/23 species (see all 23) About this table
ENSEMBL Gene Tree for KLHL10 (if available)
TreeFam Gene Tree for KLHL10 (if available) |
Paralogs
for KLHL10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHL10 gene
- KLHL172 KLHL182 KLHL202 KLHL52 KLHL122 KEAP12 KLHL282 KLHL42
- IPP2 KLHL32 KLHL82 KLHL12 KLHL22
18/33 SIMAP similar genes for KLHL10 using alignment to 3 protein entries: KLH10_HUMAN (see all proteins)
(see all similar genes):ZBTB7C ZBTB21 HIC1 ZBTB14 ZBTB38 KLHL28
KLHL2 KLHL12 ZBTB16 KLHL18 KLHL24 KLHL1
KLHL17 KLHL3 KLHL32 KLHL36 KLHL4 MYNN
KLHL10 for paralogs About GeneDecksing
|
Genomic Variants
for KLHL10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHL10 (39991937 - 40004636 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLHL10: --
Human Gene Mutation Database (HGMD): KLHL10
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL10 |
|
Disorders
/ Diseases
for KLHL10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLHL10 for disorders About GeneDecksing
OMIM gene information: 608778
OMIM disorders: --
4  diseases for KLHL10: About MalaCardsmale infertility oligospermia infertility azoospermia
1 disease from the University of Copenhagen DISEASES database for KLHL10:Male infertility Human Genome Epidemiology (HuGE) Navigator: KLHL10 (1 document)
Export disorders for KLHL10 gene to outside databases
|
Publications
for KLHL10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHL10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHL10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. (PubMed id 15136734)1, 2, 9 Yan W.... Matzuk M.M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- [Mutation of KLHL-10 in idiopathic infertile males wi th azoospermia, oligospermia or asthenospermia] (PubMed id 20218307)1 Qiu Q.M....Lu G.X. (2009)
- Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. (PubMed id 17047026)1 Yatsenko A.N....Matzuk M.M. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KLHL10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLHL10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHL10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHL10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHL10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLHL10 gene:
Search GeneIP for patents involving KLHL10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHL10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLHL10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHL10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHL10 | | | OriGene Protein Over-expression Lysate for KLHL10 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLHL10 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHL10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KLHL10 | | OriGene Custom Protein Services for KLHL10 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHL10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHL10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHL10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHL10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHL10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHL10 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for KLHL10 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | KLHL10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL10 |
|  |  |  | | | | Search ThermoFisher Antibodies for KLHL10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL10 |
|
|
|
|
