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Aliases for KLHL10 Gene

Aliases for KLHL10 Gene

  • Kelch-Like Family Member 10 2 3
  • SPGF11 3 6
  • Kelch-Like 10 (Drosophila) 2
  • Kelch-Like Protein 10 3
  • Kelch-Like 10 3

External Ids for KLHL10 Gene

Previous GeneCards Identifiers for KLHL10 Gene

  • GC17U900007
  • GC17P039902
  • GC17P040367
  • GC17P037248
  • GC17P039992
  • GC17P035755

Summaries for KLHL10 Gene

GeneCards Summary for KLHL10 Gene

KLHL10 (Kelch-Like Family Member 10) is a Protein Coding gene. Diseases associated with KLHL10 include spermatogenic failure 11 and oligospermia. An important paralog of this gene is KLHL5.

UniProtKB/Swiss-Prot for KLHL10 Gene

  • May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHL10 Gene

Genomics for KLHL10 Gene

Regulatory Elements for KLHL10 Gene

Genomic Location for KLHL10 Gene

41,835,685 bp from pter
41,848,384 bp from pter
12,700 bases
Plus strand

Genomic View for KLHL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHL10 Gene

Proteins for KLHL10 Gene

  • Protein details for KLHL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch-like protein 10
    Protein Accession:
    Secondary Accessions:
    • Q6NW28
    • Q96MC0

    Protein attributes for KLHL10 Gene

    608 amino acids
    Molecular mass:
    68942 Da
    Quaternary structure:
    • Self-associates (Probable). Interacts with CUL3; indicative for the participation in an E3 ubiquitin ligase complex (By similarity).
    • Sequence=BAB71387.1; Type=Erroneous termination; Positions=609; Note=Translated as stop.; Evidence={ECO:0000305};

neXtProt entry for KLHL10 Gene

Proteomics data for KLHL10 Gene at MOPED

Post-translational modifications for KLHL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHL10 Gene

Domains for KLHL10 Gene

Gene Families for KLHL10 Gene

  • BTBD :BTB/POZ domain containing
  • KLHL :Kelch-like

Suggested Antigen Peptide Sequences for KLHL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6JEL2
  • Contains 1 BTB (POZ) domain.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHL10: view

Function for KLHL10 Gene

Molecular function for KLHL10 Gene

UniProtKB/Swiss-Prot Function: May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis

Gene Ontology (GO) - Molecular Function for KLHL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHL10: view

Phenotypes for KLHL10 Gene

genes like me logo Genes that share phenotypes with KLHL10: view

Animal Models for KLHL10 Gene

MGI Knock Outs for KLHL10:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KLHL10 Gene

Localization for KLHL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHL10 Gene


Subcellular locations from

Jensen Localization Image for KLHL10 Gene COMPARTMENTS Subcellular localization image for KLHL10 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for KLHL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0031463 Cul3-RING ubiquitin ligase complex IEA --
genes like me logo Genes that share ontologies with KLHL10: view

Pathways for KLHL10 Gene

SuperPathways for KLHL10 Gene

No Data Available

UniProtKB/Swiss-Prot Q6JEL2-KLH10_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for KLHL10 Gene

Gene Ontology (GO) - Biological Process for KLHL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0007286 spermatid development IEA --
GO:0008584 male gonad development IEA --
GO:0009566 fertilization IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with KLHL10: view

No data available for Pathways by source for KLHL10 Gene

Transcripts for KLHL10 Gene

mRNA/cDNA for KLHL10 Gene

Unigene Clusters for KLHL10 Gene

Kelch-like family member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHL10 Gene

No ASD Table

Relevant External Links for KLHL10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHL10 Gene

mRNA expression in normal human tissues for KLHL10 Gene

mRNA differential expression in normal tissues according to GTEx for KLHL10 Gene

This gene is overexpressed in Testis (38.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLHL10 Gene

SOURCE GeneReport for Unigene cluster for KLHL10 Gene Hs.127510

genes like me logo Genes that share expressions with KLHL10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KLHL10 Gene

Orthologs for KLHL10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHL10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLHL10 35
  • 99.73 (n)
  • 99.67 (a)
KLHL10 36
  • 100 (a)
(Bos Taurus)
Mammalia KLHL10 35
  • 94.02 (n)
  • 98.85 (a)
KLHL10 36
  • 99 (a)
(Canis familiaris)
Mammalia KLHL10 35
  • 93.31 (n)
  • 98.68 (a)
KLHL10 36
  • 99 (a)
(Mus musculus)
Mammalia Klhl10 35
  • 91.34 (n)
  • 98.85 (a)
Klhl10 16
Klhl10 36
  • 99 (a)
(Monodelphis domestica)
Mammalia KLHL10 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia KLHL10 36
  • 65 (a)
(Rattus norvegicus)
Mammalia Klhl10 35
  • 91.28 (n)
  • 98.85 (a)
(Gallus gallus)
Aves KLHL10 35
  • 75.34 (n)
  • 80.14 (a)
KLHL10 36
  • 80 (a)
(Anolis carolinensis)
Reptilia KLHL10 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhl10 35
  • 62.67 (n)
  • 59.39 (a)
(Danio rerio)
Actinopterygii KLHL10 (2 of 3) 36
  • 57 (a)
KLHL10 (3 of 3) 36
  • 57 (a)
klhl10a 36
  • 56 (a)
LOC560458 35
  • 63.43 (n)
  • 58.16 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003895 35
  • 51.28 (n)
  • 45.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta klhl10 35
  • 52.88 (n)
  • 46.83 (a)
klhl10 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
-- 36
  • 45 (a)
Species with no ortholog for KLHL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHL10 Gene

Gene Tree for KLHL10 (if available)
Gene Tree for KLHL10 (if available)

Paralogs for KLHL10 Gene

genes like me logo Genes that share paralogs with KLHL10: view

Variants for KLHL10 Gene

Sequence variations from dbSNP and Humsavar for KLHL10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1044777 -- 41,848,632(-) AGAAC(A/C)CCTTG downstream-variant-500B
rs1529933 -- 41,841,889(-) ATGTC(A/G)GGAGA reference, synonymous-codon
rs4372739 -- 41,839,201(+) tggtc(A/G)gtctg intron-variant
rs4378664 -- 41,839,974(+) TCCCA(A/T)GTTCA intron-variant
rs4513146 -- 41,839,053(+) gtggc(C/G)tgatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHL10 Gene

Variant ID Type Subtype PubMed ID
nsv833447 CNV Loss 17160897
nsv908238 CNV Loss 21882294

Relevant External Links for KLHL10 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHL10 Gene

Disorders for KLHL10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for KLHL10 Gene including...

Search for KLHL10 Gene in MalaCards »

(1) OMIM Diseases for KLHL10 Gene (608778)


  • Spermatogenic failure 11 (SPGF11) [MIM:615081]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Oligozoospermia is usually observed in SPGF11 patients. In addition to oligozoospermia, teratozoospermia and moderate asthenozoospermia is observed in some cases. {ECO:0000269 PubMed:17047026}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KLHL10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KLHL10: view

Publications for KLHL10 Gene

  1. Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. (PMID: 15136734) Yan W. … Matzuk M.M. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. (PMID: 17047026) Yatsenko A.N. … Matzuk M.M. (Hum. Mol. Genet. 2006) 3 4
  4. [Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. (PMID: 20218307) Qiu Q.M. … Lu G.X. (Zhonghua Nan Ke Xue 2009) 3 48
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for KLHL10 Gene

Sources for KLHL10 Gene

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