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KLHL1 Gene

protein-coding   GIFtS: 55
GCID: GC13M070274

Kelch-Like Family Member 1

(Previous names: kelch (Drosophila)-like 1, kelch-like 1 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch-Like Family Member 11 2     Kelch-Like 1 (Drosophila)1
Kelch-Like Protein 11 2     MRP22
Mayven-Related Protein 21 2     KIAA14903
Kelch (Drosophila)-Like 11     

External Ids:    HGNC: 63521   Entrez Gene: 576262   Ensembl: ENSG000001503617   OMIM: 6053325   UniProtKB: Q9NR643   

Export aliases for KLHL1 gene to outside databases

Previous GC identifers: GC13M068242 GC13M064269 GC13M069211 GC13M068072 GC13M069172 GC13M050976


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLHL1 Gene:
The KLHL1 protein belongs to a family of actin-organizing proteins related to Drosophila Kelch (Nemes et al., 2000
(PubMed 10888605)).(supplied by OMIM, Feb 2010)

GeneCards Summary for KLHL1 Gene:
KLHL1 (kelch-like family member 1) is a protein-coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is KLHL17.

UniProtKB/Swiss-Prot: KLHL1_HUMAN, Q9NR64
Function: May play a role in organizing the actin cytoskeleton of the brain cells

Gene Wiki entry for KLHL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHL1 gene promoter:
         TBP   NF-AT2   Pax-5   TFIID   Nkx2-5   NF-AT   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHL1 promoter sequence
   Search Chromatin IP Primers for KLHL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q21   Ensembl cytogenetic band:  13q21.33   HGNC cytogenetic band: 13q21

KLHL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHL1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M070274:  view genomic region     (about GC identifiers)

Start:
70,274,725 bp from pter      End:
70,682,625 bp from pter
Size:
407,901 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLHL1_HUMAN, Q9NR64 (See protein sequence)
Recommended Name: Kelch-like protein 1  
Size: 748 amino acids; 82680 Da
Sequence caution: Sequence=BAA96014.1; Type=Erroneous initiation;
Secondary accessions: A8K5X0 Q5VZ64 Q9H4X4 Q9NR65 Q9P238

Explore the universe of human proteins at neXtProt for KLHL1: NX_Q9NR64

Explore proteomics data for KLHL1 at MOPED


See KLHL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001273654.1  NP_065917.1  

ENSEMBL proteins: 
 ENSP00000367075   ENSP00000439602  

KLHL1 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
BTBD: BTB/POZ domain containing
KLHL: Kelch-like

Selected InterPro protein domains (see all 6):
 IPR006652 Kelch_1
 IPR011333 BTB/POZ_fold
 IPR015916 Gal_Oxidase_b-propeller
 IPR013069 BTB_POZ
 IPR011705 BACK

Graphical View of Domain Structure for InterPro Entry Q9NR64

ProtoNet protein and cluster: Q9NR64

2 Blocks protein domains:
IPB000210 BTB/POZ domain
IPB011705 BTB/Kelch-associated


UniProtKB/Swiss-Prot: KLHL1_HUMAN, Q9NR64
Similarity: Contains 1 BTB (POZ) domain
Similarity: Contains 6 Kelch repeats


Find genes that share domains with KLHL1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: KLHL1_HUMAN, Q9NR64
Function: May play a role in organizing the actin cytoskeleton of the brain cells

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003779actin binding NAS10888605
GO:0005515protein binding ----
     
Find genes that share ontologies with KLHL1           About GenesLikeMe


Phenotypes:
     7 GenomeRNAi human phenotypes for KLHL1:
 Decreased Tat-dependent transc  Decreased p24 protein expressi  Decreased viability with pacli  Increased S DNA content 
 Increased cell death HMECs cel  Increased cilium length after   Increased homologous recombina 

     2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klhl1):
 behavior/neurological  nervous system 

Find genes that share phenotypes with KLHL1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Klhl1/Atxn8osKlhl1/tm1.1Mdk for KLHL1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHL1
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHL1

miRNA
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miRTarBase miRNAs that target KLHL1:
hsa-mir-335-5p (MIRT017546)

Block miRNA regulation of human, mouse, rat KLHL1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KLHL1 (see all 9):
hsa-miR-3163 hsa-miR-520d-5p hsa-miR-101* hsa-miR-618 hsa-miR-33a* hsa-miR-9 hsa-miR-4302 hsa-miR-524-5p
SwitchGear 3'UTR luciferase reporter plasmidKLHL1 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat KLHL1

Gene Editing
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL1

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
KLHL1_HUMAN, Q9NR64: Cytoplasm, cytoskeleton
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton5
cytosol3
endosome1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IDA10888605
GO:0005856cytoskeleton IEA--
GO:0030425dendrite IEA--
GO:0043025neuronal cell body IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHL1
Interactions:

    GeneGlobe Interaction Network for KLHL1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for KLHL1 (Q9NR643 ENSP000003670754) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
BMPR1BO002383, ENSP000002645684I2D: score=2 STRING: ENSP00000264568
TGFBR1P368973, ENSP000003641334I2D: score=2 STRING: ENSP00000364133
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007626locomotory behavior ----
GO:0007628adult walking behavior IEA--
GO:0016358dendrite development IEA--
GO:0021680cerebellar Purkinje cell layer development IEA--
GO:0030036actin cytoskeleton organization NAS10888605

Find genes that share ontologies with KLHL1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for KLHL1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for KLHL1 gene (2 alternative transcripts): 
NM_001286725.1  NM_020866.2  

Unigene Cluster for KLHL1:

Kelch-like family member 1
Hs.508201  [show with all ESTs]
Unigene Representative Sequence: NM_020866
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000377844(uc001vip.3 uc010thm.2) ENST00000545028
miRNA
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Block miRNA regulation of human, mouse, rat KLHL1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KLHL1 (see all 9):
hsa-miR-3163 hsa-miR-520d-5p hsa-miR-101* hsa-miR-618 hsa-miR-33a* hsa-miR-9 hsa-miR-4302 hsa-miR-524-5p
SwitchGear 3'UTR luciferase reporter plasmidKLHL1 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat KLHL1
Clone
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GenScript: all cDNA clones in your preferred vector: KLHL1 (NM_025010)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHL1
Primer
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OriGene qPCR primer pairs and template standards for KLHL1
OriGene qSTAR qPCR primer pairs in human, mouse for KLHL1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHL1
  QuantiTect SYBR Green Assays in human, mouse, rat KLHL1
  QuantiFast Probe-based Assays in human, mouse, rat KLHL1

Additional mRNA sequence: 

AB040923.1 AF252283.1 AK054609.1 AK291435.1 AK295939.1 BC022460.1 

3 DOTS entries:

DT.205884  DT.95293922  DT.120794577 

1 AceView cDNA sequence:

BG703629 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for KLHL1    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:                                                                    -                           
SP2:                                                                                                
SP3:              -                                                                                 


ECgene alternative splicing isoforms for KLHL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KLHL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
KLHL1 Expression
About this image


KLHL1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
 
 Neurons
         Mature Rod Cells Outer Nuclear Layer
 
 Eye (Sensory Organs)
         Mature Rod Cells Outer Nuclear Layer
 
 Brain (Nervous System)
         Medulla Oblongata
KLHL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KLHL1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.508201

UniProtKB/Swiss-Prot: KLHL1_HUMAN, Q9NR64
Tissue specificity: Highly expressed in brain

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for KLHL1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Klhl11 , 5 kelch-like 1 (Drosophila)5
kelch-like 11
89.26(n)1
95.59(a)1
  14 (46.92 cM)5
936881  NM_053105.21  NP_444335.21 
 961052595 
chicken
(Gallus gallus)
Aves KLHL11 kelch-like 1 (Drosophila) 82.43(n)
90.49(a)
  418799  XM_416994.3  XP_416994.2 
lizard
(Anolis carolinensis)
Reptilia KLHL16
kelch-like family member 1
88(a)
1 ↔ 1
3(81488384-81690829)
fruit fly
(Drosophila melanogaster)
Insecta CG177543   -- 58(a)
(best of 3)
  8D10   --


ENSEMBL Gene Tree for KLHL1 (if available)
TreeFam Gene Tree for KLHL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KLHL1 gene
KLHL172  KLHL182  KLHL202  KLHL52  KLHL122  KEAP12  KLHL282  KLHL42  
KLHL32  KLHL82  KLHL102  KLHL22  
Selected SIMAP similar genes for KLHL1 using alignment to 4 protein entries:     KLHL1_HUMAN (see all proteins) (see all similar genes):
DKFZp761P1717    KLHL5    KLHL4    KLHL20    KLHL17    KLHL3
KLHL32    KLHL28    KLHL12    KLHL2    KLHL8    KLHL18
DKFZp686P15123    DKFZp686H07112    KBTBD8    DKFZp781C1855    KLHL22    KLHL10

Find genes that share paralogs with KLHL1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KLHL1 (see all 9432)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs675791891,2
C--51056265(+) TATAT-/GTATATA 1 -- int11Minor allele frequency- GT:0.00NA 2
rs58044671,2
C--51312858(+) TTTTT-/T/TT  
        
CTGTC
1 -- int1 trp31NA 2
rs105556751,2
C--51377423(+) TTGTC-/CT    
   T
/TTC
CAACT
2 -- int1 cds10--------
rs664826781,2
C--51377424(+) TGTCC-/TTCAACTA 1 -- int11Minor allele frequency- TTC:0.00NA 2
rs1885865531,2
--70274232(+) TATTAC/TCCTAT 1 -- ds50010--------
rs2017645891,2
C--70274240(+) TATTA-/TTTTTT 1 -- ds50010--------
rs1913776711,2
--70274295(+) TTTGAC/TCATGT 1 -- ds50010--------
rs1832504811,2
--70274371(+) CTTGGA/TTGTTA 1 -- ds50010--------
rs1167120921,2
C,F--70274397(+) TGGCTA/CCCTAA 1 -- ds50011Minor allele frequency- C:0.03WA 118
rs95722401,2
C--70274454(+) AGGTTT/GTCTTG 1 -- ds50011Minor allele frequency- G:0.00NA 2

HapMap Linkage Disequilibrium report for KLHL1 (70274725 - 70524725 bp, first 250kb of KLHL1)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for KLHL1 (see all 23):    About this table    
Variant IDTypeSubtypePubMed ID
esv2659407CNV Deletion23128226
esv2422425CNV Deletion17116639
nsv436166CNV Deletion17901297
esv2678945CNV Deletion23128226
esv2405237CNV Deletion18987734
esv2747588CNV Deletion23290073
esv2564277CNV Deletion19546169
nsv900482CNV Loss21882294
nsv900481CNV Loss21882294
nsv510347CNV Loss20534489

Human Gene Mutation Database (HGMD): KLHL1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing KLHL1
DNA2.0 Custom Variant and Variant Library Synthesis for KLHL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605332    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for KLHL1:
Spinocerebellar ataxia

Find genes that share disorders with KLHL1           About GenesLikeMe

Genetic Association Database (GAD): KLHL1
Human Genome Epidemiology (HuGE) Navigator: KLHL1 (2 documents)

Export disorders for KLHL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KLHL1 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with KLHL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1). (PubMed id 10888605)1, 2, 3, 9 Koob M.D.... Benzow K.A. (Hum. Mol. Genet. 2000)
  2. UGT1A1 is a major locus influencing bilirubin levels in African Americans. (PubMed id 22085899)1, 4 Chen G....Rotimi C.N. (Eur. J. Hum. Genet. 2012)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
  7. The Kelch-like protein 1 modulates P/Q-type calcium current density. (PubMed id 17289272)1, 9 Aromolaran K.A....Piedras-RenterA-a E.S. (Neuroscience 2007)
  8. Update on the Kelch-like (KLHL) gene family. (PubMed id 23676014)1 Dhanoa B.S....Friedman J.S. (Hum. Genomics 2013)
  9. Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). (PubMed id 22952603)1 Hart A.B....Palmer A.A. (PLoS ONE 2012)
  10. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
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OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57626 HGNC: 6352 AceView: KLHL1.1 Ensembl:ENSG00000150361 euGenes: HUgn57626
ECgene: KLHL1 H-InvDB: KLHL1

(According to HUGE)
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HUGE: KIAA1490

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KLHL1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KLHL1 gene:
Search GeneIP for patents involving KLHL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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