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Aliases for KLHDC9 Gene

Aliases for KLHDC9 Gene

  • Kelch Domain Containing 9 2 3 5
  • Kelch/Ankyrin Repeat-Containing Cyclin A1-Interacting Protein 3 4
  • KARCA1 3 4
  • Kelch/Ankyrin Repeat Containing Cyclin A1 Interacting Protein 2
  • Kelch Domain-Containing Protein 9 3

External Ids for KLHDC9 Gene

Previous GeneCards Identifiers for KLHDC9 Gene

  • GC01P159335
  • GC01P161068
  • GC01P132425

Summaries for KLHDC9 Gene

GeneCards Summary for KLHDC9 Gene

KLHDC9 (Kelch Domain Containing 9) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC9 Gene

Genomics for KLHDC9 Gene

Regulatory Elements for KLHDC9 Gene

Enhancers for KLHDC9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G161011 1.9 FANTOM5 ENCODE dbSUPER 22.3 -81.1 -81148 11.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TSTD1 ARHGAP30 KLHDC9 FCGR2A USF1 RPSAP18 DEDD LOC105371471 NECTIN4 F11R
GH01G161096 1.2 ENCODE 17.8 -0.7 -683 2.9 AGO1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 TBX21 DUSP12 RPSAP18 ENSG00000228606 KLHDC9 ATF6 FCER1G NDUFS2 B4GALT3 NIT1 NECTIN4
GH01G161066 1.7 FANTOM5 ENCODE dbSUPER 11.2 -29.7 -29747 5.1 HDGF PKNOX1 AGO1 WRNIP1 SIN3A YY1 GLIS2 ELK1 ZNF143 ZNF207 FCGR2A TSTD1 ARHGAP30 F11R DUSP12 DEDD NECTIN4 ENSG00000232879 KLHDC9 USF1
GH01G161008 1.6 Ensembl ENCODE dbSUPER 10.9 -88.6 -88649 2.1 PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF766 ZNF263 SP5 ZNF592 MIER3 TSTD1 ENSG00000232879 USF1 ARHGAP30 LOC105371471 NECTIN4 DEDD KLHDC9 ENSG00000228863 F11R
GH01G161043 1.4 ENCODE dbSUPER 11.6 -51.5 -51473 5.8 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D TSTD1 ARHGAP30 LOC105371471 NECTIN4 KLHDC9 UFC1 USP21 ENSG00000224985 PPOX DEDD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLHDC9 on UCSC Golden Path with GeneCards custom track

Promoters for KLHDC9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014635 -61 1001 AGO1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 TBX21

Genomic Location for KLHDC9 Gene

Chromosome:
1
Start:
161,098,361 bp from pter
End:
161,100,348 bp from pter
Size:
1,988 bases
Orientation:
Plus strand

Genomic View for KLHDC9 Gene

Genes around KLHDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC9 Gene

Proteins for KLHDC9 Gene

  • Protein details for KLHDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEP7-KLDC9_HUMAN
    Recommended name:
    Kelch domain-containing protein 9
    Protein Accession:
    Q8NEP7
    Secondary Accessions:
    • Q5SY56
    • Q6NXT9
    • Q6PKN4
    • Q8N5E1
    • Q8NA16

    Protein attributes for KLHDC9 Gene

    Size:
    349 amino acids
    Molecular mass:
    37754 Da
    Quaternary structure:
    • Interacts with CCNA1.

    Alternative splice isoforms for KLHDC9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHDC9 Gene

Post-translational modifications for KLHDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHDC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC9 Gene

Domains & Families for KLHDC9 Gene

Protein Domains for KLHDC9 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHDC9: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KLHDC9 Gene

Function for KLHDC9 Gene

genes like me logo Genes that share phenotypes with KLHDC9: view

Animal Model Products

CRISPR Products

miRNA for KLHDC9 Gene

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC9 Gene

Localization for KLHDC9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHDC9 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHDC9 Gene

Pathways & Interactions for KLHDC9 Gene

SuperPathways for KLHDC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KLHDC9 Gene

Drugs & Compounds for KLHDC9 Gene

No Compound Related Data Available

Transcripts for KLHDC9 Gene

Unigene Clusters for KLHDC9 Gene

Kelch domain containing 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: - -
SP2:
SP3: -
SP4: -
SP5: - - -

Relevant External Links for KLHDC9 Gene

GeneLoc Exon Structure for
KLHDC9
ECgene alternative splicing isoforms for
KLHDC9

Expression for KLHDC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHDC9 Gene

mRNA differential expression in normal tissues according to GTEx for KLHDC9 Gene

This gene is overexpressed in Testis (x7.9).

NURSA nuclear receptor signaling pathways regulating expression of KLHDC9 Gene:

KLHDC9

SOURCE GeneReport for Unigene cluster for KLHDC9 Gene:

Hs.507290
genes like me logo Genes that share expression patterns with KLHDC9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHDC9 Gene

Orthologs for KLHDC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHDC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHDC9 34 35
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia KLHDC9 34 35
  • 85.98 (n)
mouse
(Mus musculus)
Mammalia Klhdc9 34 16 35
  • 82.52 (n)
rat
(Rattus norvegicus)
Mammalia Klhdc9 34
  • 82.14 (n)
dog
(Canis familiaris)
Mammalia KLHDC9 34 35
  • 81.94 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHDC9 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHDC9 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc9 34
  • 58.88 (n)
Species where no ortholog for KLHDC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLHDC9 Gene

ENSEMBL:
Gene Tree for KLHDC9 (if available)
TreeFam:
Gene Tree for KLHDC9 (if available)

Paralogs for KLHDC9 Gene

(1) SIMAP similar genes for KLHDC9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHDC9: view

No data available for Paralogs for KLHDC9 Gene

Variants for KLHDC9 Gene

Sequence variations from dbSNP and Humsavar for KLHDC9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000362393 -- 161,099,213(+) CTCTC(C/T)ACAGT intron-variant
rs1000473365 -- 161,098,841(+) TCTCG(A/C)CGCTT nc-transcript-variant, reference, synonymous-codon
rs1000766825 -- 161,097,524(+) TTGCA(C/T)CTGGG upstream-variant-2KB
rs1001093052 -- 161,097,698(+) TCTCT(A/C/T)TCTCT upstream-variant-2KB
rs1001370496 -- 161,096,879(+) TCAGC(A/C)AAGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLHDC9 Gene

Variant ID Type Subtype PubMed ID
nsv1161729 CNV duplication 26073780

Variation tolerance for KLHDC9 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHDC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHDC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC9 Gene

Disorders for KLHDC9 Gene

Relevant External Links for KLHDC9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHDC9

No disorders were found for KLHDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC9 Gene

Publications for KLHDC9 Gene

  1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PMID: 15159402) Diederichs S. … Mueller-Tidow C. (J. Biol. Chem. 2004) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64

Products for KLHDC9 Gene

Sources for KLHDC9 Gene

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