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Aliases for KLHDC9 Gene

Aliases for KLHDC9 Gene

  • Kelch Domain Containing 9 2 3 5
  • Kelch/Ankyrin Repeat-Containing Cyclin A1-Interacting Protein 3 4
  • KARCA1 3 4
  • Kelch/Ankyrin Repeat Containing Cyclin A1 Interacting Protein 2
  • Kelch Domain-Containing Protein 9 3

External Ids for KLHDC9 Gene

Previous GeneCards Identifiers for KLHDC9 Gene

  • GC01P159335
  • GC01P161068
  • GC01P132425

Summaries for KLHDC9 Gene

GeneCards Summary for KLHDC9 Gene

KLHDC9 (Kelch Domain Containing 9) is a Protein Coding gene.

Additional gene information for KLHDC9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC9 Gene

Genomics for KLHDC9 Gene

GeneHancer (GH) Regulatory Elements for KLHDC9 Gene

Promoters and enhancers for KLHDC9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I161096 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 567.8 -0.7 -683 2.9 YBX1 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 MCM3 KLHDC9 USP21 DUSP12 PPOX LOC100287049 DEDD NCSTN RPSAP18 LOC148430 DCAF8
GH01I161011 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 22.3 -81.1 -81148 11.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 DUSP12 USP21 LOC100287049 DEDD PPOX TSTD1 LOC148430 B4GALT3 ARHGAP30 KLHDC9
GH01I161066 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.2 -29.7 -29746 5.1 HDGF PKNOX1 BMI1 ZBTB40 KLF5 IRF4 ZNF207 ZNF143 ATF7 ETV6 ARHGAP30 FCGR2A TSTD1 DUSP12 USP21 PPOX F11R DEDD NECTIN4 ENSG00000232879
GH01I161043 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.6 -51.5 -51472 5.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 PIR33280 USF1 GC01P161046 DEDD TSTD1 LOC100287049 ARHGAP30 LOC105371471 NECTIN4 KLHDC9
GH01I161008 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.9 -88.6 -88649 2.1 PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF121 ZNF766 GATA2 ATF7 NCOA1 ENSG00000232879 TSTD1 USF1 ARHGAP30 LOC105371471 NECTIN4 DEDD KLHDC9 ENSG00000228863 F11R
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLHDC9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLHDC9 gene promoter:

Genomic Locations for KLHDC9 Gene

Genomic Locations for KLHDC9 Gene
chr1:161,098,361-161,100,348
(GRCh38/hg38)
Size:
1,988 bases
Orientation:
Plus strand
chr1:161,068,151-161,070,138
(GRCh37/hg19)

Genomic View for KLHDC9 Gene

Genes around KLHDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC9 Gene

Proteins for KLHDC9 Gene

  • Protein details for KLHDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEP7-KLDC9_HUMAN
    Recommended name:
    Kelch domain-containing protein 9
    Protein Accession:
    Q8NEP7
    Secondary Accessions:
    • Q5SY56
    • Q6NXT9
    • Q6PKN4
    • Q8N5E1
    • Q8NA16

    Protein attributes for KLHDC9 Gene

    Size:
    349 amino acids
    Molecular mass:
    37754 Da
    Quaternary structure:
    • Interacts with CCNA1.

    Alternative splice isoforms for KLHDC9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHDC9 Gene

Post-translational modifications for KLHDC9 Gene

No Post-translational modifications

Other Protein References for KLHDC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC9 Gene

Domains & Families for KLHDC9 Gene

Gene Families for KLHDC9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KLHDC9 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KLHDC9: view

No data available for UniProtKB/Swiss-Prot for KLHDC9 Gene

Function for KLHDC9 Gene

Phenotypes From GWAS Catalog for KLHDC9 Gene

Gene Ontology (GO) - Molecular Function for KLHDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030332 cyclin binding IPI 15159402
genes like me logo Genes that share ontologies with KLHDC9: view
genes like me logo Genes that share phenotypes with KLHDC9: view

Animal Model Products

miRNA for KLHDC9 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC9 Gene

Localization for KLHDC9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLHDC9 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLHDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with KLHDC9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KLHDC9 Gene

Pathways & Interactions for KLHDC9 Gene

SuperPathways for KLHDC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KLHDC9: view

No data available for Pathways by source and SIGNOR curated interactions for KLHDC9 Gene

Drugs & Compounds for KLHDC9 Gene

No Compound Related Data Available

Transcripts for KLHDC9 Gene

Unigene Clusters for KLHDC9 Gene

Kelch domain containing 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: - -
SP2:
SP3: -
SP4: -
SP5: - - -

Relevant External Links for KLHDC9 Gene

GeneLoc Exon Structure for
KLHDC9
ECgene alternative splicing isoforms for
KLHDC9

Expression for KLHDC9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLHDC9 Gene

mRNA differential expression in normal tissues according to GTEx for KLHDC9 Gene

This gene is overexpressed in Testis (x7.9).

NURSA nuclear receptor signaling pathways regulating expression of KLHDC9 Gene:

KLHDC9

SOURCE GeneReport for Unigene cluster for KLHDC9 Gene:

Hs.507290

Evidence on tissue expression from TISSUES for KLHDC9 Gene

  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with KLHDC9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLHDC9 Gene

Orthologs for KLHDC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHDC9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHDC9 33 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia KLHDC9 33 34
  • 85.98 (n)
mouse
(Mus musculus)
Mammalia Klhdc9 33 16 34
  • 82.52 (n)
rat
(Rattus norvegicus)
Mammalia Klhdc9 33
  • 82.14 (n)
dog
(Canis familiaris)
Mammalia KLHDC9 33 34
  • 81.94 (n)
oppossum
(Monodelphis domestica)
Mammalia KLHDC9 34
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHDC9 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc9 33
  • 58.88 (n)
Species where no ortholog for KLHDC9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLHDC9 Gene

ENSEMBL:
Gene Tree for KLHDC9 (if available)
TreeFam:
Gene Tree for KLHDC9 (if available)

Paralogs for KLHDC9 Gene

(1) SIMAP similar genes for KLHDC9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHDC9: view

No data available for Paralogs for KLHDC9 Gene

Variants for KLHDC9 Gene

Sequence variations from dbSNP and Humsavar for KLHDC9 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000362393 -- 161,099,213(+) T/C intron_variant
rs1000473365 -- 161,098,841(+) C/A/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000766825 -- 161,097,524(+) T/C upstream_transcript_variant
rs1001093052 -- 161,097,698(+) C/A/T upstream_transcript_variant
rs1001370496 -- 161,096,879(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KLHDC9 Gene

Variant ID Type Subtype PubMed ID
nsv1161729 CNV duplication 26073780

Variation tolerance for KLHDC9 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLHDC9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLHDC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC9 Gene

Disorders for KLHDC9 Gene

Additional Disease Information for KLHDC9

No disorders were found for KLHDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC9 Gene

Publications for KLHDC9 Gene

  1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PMID: 15159402) Diederichs S … Müller-Tidow C (The Journal of biological chemistry 2004) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A … Carmell MA (Nature 2006) 3 58

Products for KLHDC9 Gene

Sources for KLHDC9 Gene

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