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Aliases for KLHDC9 Gene

Aliases for KLHDC9 Gene

  • Kelch Domain Containing 9 2 3 5
  • Kelch/Ankyrin Repeat-Containing Cyclin A1-Interacting Protein 3 4
  • KARCA1 3 4
  • Kelch/Ankyrin Repeat Containing Cyclin A1 Interacting Protein 2

External Ids for KLHDC9 Gene

Previous GeneCards Identifiers for KLHDC9 Gene

  • GC01P159335
  • GC01P161068
  • GC01P132425

Summaries for KLHDC9 Gene

GeneCards Summary for KLHDC9 Gene

KLHDC9 (Kelch Domain Containing 9) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC9 Gene

Genomics for KLHDC9 Gene

Regulatory Elements for KLHDC9 Gene

Promoters for KLHDC9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHDC9 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHDC9 Gene

Chromosome:
1
Start:
161,098,361 bp from pter
End:
161,100,348 bp from pter
Size:
1,988 bases
Orientation:
Plus strand

Genomic View for KLHDC9 Gene

Genes around KLHDC9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC9 Gene

Proteins for KLHDC9 Gene

  • Protein details for KLHDC9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEP7-KLDC9_HUMAN
    Recommended name:
    Kelch domain-containing protein 9
    Protein Accession:
    Q8NEP7
    Secondary Accessions:
    • Q5SY56
    • Q6NXT9
    • Q6PKN4
    • Q8N5E1
    • Q8NA16

    Protein attributes for KLHDC9 Gene

    Size:
    349 amino acids
    Molecular mass:
    37754 Da
    Quaternary structure:
    • Interacts with CCNA1.

    Alternative splice isoforms for KLHDC9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHDC9 Gene

Proteomics data for KLHDC9 Gene at MOPED

Post-translational modifications for KLHDC9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHDC9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC9 Gene

Domains & Families for KLHDC9 Gene

Protein Domains for KLHDC9 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEP7

UniProtKB/Swiss-Prot:

KLDC9_HUMAN :
  • Contains 3 Kelch repeats.
Similarity:
  • Contains 3 Kelch repeats.
genes like me logo Genes that share domains with KLHDC9: view

No data available for Gene Families for KLHDC9 Gene

Function for KLHDC9 Gene

genes like me logo Genes that share phenotypes with KLHDC9: view

Animal Model Products

miRNA for KLHDC9 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC9 Gene

Localization for KLHDC9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHDC9 Gene COMPARTMENTS Subcellular localization image for KLHDC9 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHDC9 Gene

Pathways & Interactions for KLHDC9 Gene

SuperPathways for KLHDC9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KLHDC9 Gene

Drugs & Compounds for KLHDC9 Gene

No Compound Related Data Available

Transcripts for KLHDC9 Gene

Unigene Clusters for KLHDC9 Gene

Kelch domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC9 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: - -
SP2:
SP3: -
SP4: -
SP5: - - -

Relevant External Links for KLHDC9 Gene

GeneLoc Exon Structure for
KLHDC9
ECgene alternative splicing isoforms for
KLHDC9

Expression for KLHDC9 Gene

mRNA expression in normal human tissues for KLHDC9 Gene

mRNA differential expression in normal tissues according to GTEx for KLHDC9 Gene

This gene is overexpressed in Testis (x7.9).

SOURCE GeneReport for Unigene cluster for KLHDC9 Gene Hs.507290

genes like me logo Genes that share expression patterns with KLHDC9: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KLHDC9 Gene

Orthologs for KLHDC9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHDC9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHDC9 35
  • 85.98 (n)
  • 88.18 (a)
KLHDC9 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHDC9 35
  • 81.94 (n)
  • 82.93 (a)
KLHDC9 36
  • 40 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhdc9 35
  • 82.52 (n)
  • 83.67 (a)
Klhdc9 16
Klhdc9 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHDC9 35
  • 99.62 (n)
  • 99.43 (a)
KLHDC9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhdc9 35
  • 82.14 (n)
  • 83.38 (a)
oppossum
(Monodelphis domestica)
Mammalia KLHDC9 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHDC9 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc9 35
  • 58.88 (n)
  • 54.19 (a)
Species with no ortholog for KLHDC9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLHDC9 Gene

ENSEMBL:
Gene Tree for KLHDC9 (if available)
TreeFam:
Gene Tree for KLHDC9 (if available)

Paralogs for KLHDC9 Gene

(1) SIMAP similar genes for KLHDC9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHDC9: view

No data available for Paralogs for KLHDC9 Gene

Variants for KLHDC9 Gene

Sequence variations from dbSNP and Humsavar for KLHDC9 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11576830 - 161,099,046(+) ACCCC(A/C)GCGCC nc-transcript-variant, reference, missense
rs1128750 -, - 161,099,754(+) CCAGA(A/G/T)CTAGA nc-transcript-variant, reference, missense
rs1128747 -- 161,098,802(+) GACGG(A/C/G)CGTTG nc-transcript-variant, reference, synonymous-codon
rs3813611 -- 161,098,450(+) GGGAA(A/G)CCCGC intron-variant, utr-variant-5-prime
rs4656288 -- 161,096,656(+) TTTCT(A/C)TCCAG upstream-variant-2KB

Variation tolerance for KLHDC9 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.41; 63.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHDC9 Gene

HapMap Linkage Disequilibrium report
KLHDC9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLHDC9 Gene

Disorders for KLHDC9 Gene

Relevant External Links for KLHDC9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHDC9

No disorders were found for KLHDC9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC9 Gene

Publications for KLHDC9 Gene

  1. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. (PMID: 15159402) Diederichs S. … Mueller-Tidow C. (J. Biol. Chem. 2004) 2 3 4 67
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  3. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PMID: 16751776) Girard A. … Carmell M.A. (Nature 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for KLHDC9 Gene

Sources for KLHDC9 Gene

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