Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KLHDC8B Gene

protein-coding   GIFtS: 50
GCID: GC03P049209

Kelch Domain Containing 8B

  See KLHDC8B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Kelch Domain Containing 8B1 2
Kelch Domain-Containing Protein 8B2

External Ids:    HGNC: 285571   Entrez Gene: 2009422   Ensembl: ENSG000001859097   OMIM: 6131695   UniProtKB: Q8IXV73   

Export aliases for KLHDC8B gene to outside databases

Previous GC identifer: GC03P049185


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KLHDC8B Gene:
This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for
protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma. (provided by
RefSeq, Sep 2010)

GeneCards Summary for KLHDC8B Gene:
KLHDC8B (kelch domain containing 8B) is a protein-coding gene. Diseases associated with KLHDC8B include hodgkin's lymphoma. An important paralog of this gene is GAN.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHDC8B gene promoter:
         E2F-4   E2F-3a   E2F-1   MAZR   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHDC8B promoter sequence
   Search Chromatin IP Primers for KLHDC8B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHDC8B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

KLHDC8B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHDC8B gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P049209:  view genomic region     (about GC identifiers)

Start:
49,209,018 bp from pter      End:
49,213,919 bp from pter
Size:
4,902 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KLD8B_HUMAN, Q8IXV7 (See protein sequence)
Recommended Name: Kelch domain-containing protein 8B  
Size: 354 amino acids; 37676 Da
Developmental stage: Transcribed predominantly during S phase, translated exclusively during mitosis and
cytokinesis and rapidly degraded after cell division

Explore the universe of human proteins at neXtProt for KLHDC8B: NX_Q8IXV7

Explore proteomics data for KLHDC8B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLHDC8B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775817.1  
    ENSEMBL proteins: 
     ENSP00000327468  

    KLHDC8B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KLHDC8B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KLHDC8B
    GenScript Custom Purified and Recombinant Proteins Services for KLHDC8B
    Novus Biologicals KLHDC8B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLHDC8B

     
    Search eBioscience for Proteins for KLHDC8B 

    KLHDC8B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for KLHDC8B
    OriGene Custom Antibody Services for KLHDC8B
    Novus Biologicals KLHDC8B Antibodies
    Abcam antibodies for KLHDC8B
    Cloud-Clone Corp. Antibodies for KLHDC8B
    Search ThermoFisher Antibodies for KLHDC8B
    LSBio Antibodies in human, mouse, rat for KLHDC8B

    KLHDC8B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLHDC8B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLHDC8B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLHDC8B
    Cloud-Clone Corp. CLIAs for KLHDC8B
    Search eBioscience for ELISAs for KLHDC8B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR006652 Kelch_1
     IPR015915 Kelch-typ_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q8IXV7

    ProtoNet protein and cluster: Q8IXV7

    1 Blocks protein domain: IPB006651 Kelch repeat signature

    UniProtKB/Swiss-Prot: KLD8B_HUMAN, Q8IXV7
    Similarity: Contains 8 Kelch repeats


    Find genes that share domains with KLHDC8B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with KLHDC8B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLHDC8B:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHDC8B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLHDC8B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHDC8B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHDC8B

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLHDC8B:
    hsa-mir-375 (MIRT019701)

    Block miRNA regulation of human, mouse, rat KLHDC8B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHDC8B (see all 29):
    hsa-miR-146b-3p hsa-let-7d hsa-miR-15a hsa-miR-202 hsa-let-7c hsa-miR-3605-5p hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidKLHDC8B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLHDC8B
    Predesigned siRNA for gene silencing in human, mouse, rat KLHDC8B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLHDC8B

    Clone
    Products:
         
    OriGene clones in human, mouse for KLHDC8B (see all 7)
    OriGene ORF clones in mouse, rat for KLHDC8B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHDC8B (NM_173546)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHDC8B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC8B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLHDC8B
    Browse ESI BIO Cell Lines and PureStem Progenitors for KLHDC8B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC8B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KLD8B_HUMAN, Q8IXV7: Cytoplasm. Note=In mitotic cells, concentrates in the midbody of the cytoplasmic bridge
    linking daughter cells as they are about to separate during cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with KLHDC8B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHDC8B
    Interactions:

        Search GeneGlobe Interaction Network for KLHDC8B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for KLHDC8B (Q8IXV72 ENSP000003274684) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    --P310162MINT-8107405
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHDC8B (KLD8B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KLHDC8B gene: 
    NM_173546.2  

    Unigene Cluster for KLHDC8B:

    Kelch domain containing 8B
    Hs.13781  [show with all ESTs]
    Unigene Representative Sequence: NM_173546
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332780(uc003cwh.3 uc003cwi.1) ENST00000459846 ENST00000476495
    ENST00000471811 ENST00000462582
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLHDC8B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLHDC8B (see all 29):
    hsa-miR-146b-3p hsa-let-7d hsa-miR-15a hsa-miR-202 hsa-let-7c hsa-miR-3605-5p hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidKLHDC8B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLHDC8B
    Predesigned siRNA for gene silencing in human, mouse, rat KLHDC8B
    Clone
    Products:
         
    OriGene clones in human, mouse for KLHDC8B (see all 7)
    OriGene ORF clones in mouse, rat for KLHDC8B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLHDC8B (NM_173546)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHDC8B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC8B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KLHDC8B
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHDC8B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHDC8B
      QuantiTect SYBR Green Assays in human, mouse, rat KLHDC8B
      QuantiFast Probe-based Assays in human, mouse, rat KLHDC8B

    Additional mRNA sequence: 

    AK294160.1 AY129011.1 BC013110.2 BC039083.1 

    6 DOTS entries:

    DT.413119  DT.95073065  DT.95073067  DT.100792822  DT.100792818  DT.100792820 

    Selected AceView cDNA sequences (see all 171):

    AA398041 T08504 BM995365 BG742019 AI740580 N90056 AI741581 AL562549 
    AI671837 N75850 NM_173546 CA397861 BX117590 BG115244 BX441438 CD515742 
    AW513166 BU168511 AI540497 BU526851 AI709284 CB268927 AA291587 BC039083 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC8B    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
    SP1:                    -     -                 -                       -               
    SP2:                                                                    -               
    SP3:              -     -     -                                                         
    SP4:                          -                 -                                       
    SP5:                                            -                                       


    ECgene alternative splicing isoforms for KLHDC8B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KLHDC8B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTCAGGG
    KLHDC8B Expression
    About this image

    KLHDC8B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHDC8B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13781
        Custom PCR Arrays for KLHDC8B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KLHDC8B
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHDC8B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHDC8B
    QuantiTect SYBR Green Assays in human, mouse, rat KLHDC8B
    QuantiFast Probe-based Assays in human, mouse, rat KLHDC8B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC8B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for KLHDC8B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhdc8b1 , 5 kelch domain containing 8B1, 5 89.92(n)1
    97.74(a)1
      9 (59.37 cM)5
    782671  NM_030075.21  NP_084351.11 
     1084476585 
    chicken
    (Gallus gallus)
    Aves KLHDC8B1 kelch domain containing 8B 70.55(n)
    69.32(a)
      416054  XM_414393.3  XP_414393.2 
    lizard
    (Anolis carolinensis)
    Reptilia KLHDC8B6
    kelch domain containing 8B
    70(a)
    1 ↔ 1
    GL343723.1(60456-118593)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klhdc8b1 kelch domain containing 8B 67.31(n)
    66.54(a)
      100488297  XM_002933072.2  XP_002933118.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7991891 kelch domain-containing protein 8B-like 62.93(n)
    63.51(a)
      799189  XM_001339539.2  XP_001339575.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C53A5.116
    C53A5.96
    (see all 3)
    Protein C53A5.9 (C53A5.9) mRNA, complete cds
    (see all 3)
    14(a)
    13(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(14562565-14564639) WBGene00008269
    V(14557038-14558866) WBGene00008267


    ENSEMBL Gene Tree for KLHDC8B (if available)
    TreeFam Gene Tree for KLHDC8B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KLHDC8B gene
    GAN2  KLHL72  IPP2  IVNS1ABP2  KLHDC8A2  
    1 SIMAP similar gene for KLHDC8B using alignment to 2 protein entries:     KLD8B_HUMAN (see all proteins):
    KLHDC8A

    Find genes that share paralogs with KLHDC8B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KLHDC8B (see all 136)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846791401,2
    --49139356(+) TCCAGC/GCTGAG 1 -- us2k10--------
    rs98138131,2
    C--49139394(+) AAAAAA/TAAATA 1 -- us2k1 tfbs30--------
    rs2000340211,2
    --49139394(+) AAAAA-/TAAATA 1 -- us2k10--------
    rs1808530091,2
    --49139442(+) CAGGAC/GGGAGT 1 -- us2k10--------
    rs1160942971,2
    F--49139839(+) ACAGTG/ACCCCA 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1874139051,2
    --49139954(+) TCTGTA/GCAGGC 1 -- us2k10--------
    rs1146127441,2
    F--49139961(+) AGGCCG/AACTGA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1405121601,2
    --49139997(+) GCAAAA/GGCTCT 1 -- us2k10--------
    rs98149871,2
    C,F,A,H--49140150(+) CCTTGT/CTCTTG 1 -- us2k118Minor allele frequency- C:0.10NS EA NA WA 2342
    rs1504244071,2
    --49140179(+) GGCCTA/GTGTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLHDC8B (49209018 - 49213919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for KLHDC8B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834686CNV Loss17160897
    nsv876764CNV Loss21882294

    Human Gene Mutation Database (HGMD): KLHDC8B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHDC8B
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHDC8B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613169   
    OMIM disorders: 236000  
    UniProtKB/Swiss-Prot: KLD8B_HUMAN, Q8IXV7
  • Hodgkin lymphoma (HL) [MIM:236000]: A malignant disease characterized by progressive enlargement of the
    lymph nodes, spleen and general lymphoid tissue, and the presence of large, usually multinucleate, cells
    (Reed-Sternberg cells). Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is
    composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils,
    eosinophils and histiocytes. Note=The disease is caused by mutations affecting the gene represented in this
    entry. A variant in the 5'-UTR of KLHDC8B, responsible for decreasing its expression, is associated with classic
    Hodgkin lymphoma and segregates with the disease in some families (PubMed:19706467)
  • Note=A chromosomal aberration disrupting KLHDC8B has been found in a family with the nodular sclerosis
    type of Hodgkin lymphoma. Translocation t(2,3)(q11.2;p21.31)

  • 1 disease for KLHDC8B:    
    About MalaCards
    hodgkin's lymphoma

    1 disease from the University of Copenhagen DISEASES database for KLHDC8B:
    Hodgkin's lymphoma

    Find genes that share disorders with KLHDC8B           About GenesLikeMe

    Genetic Association Database (GAD): KLHDC8B

    Export disorders for KLHDC8B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KLHDC8B gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with KLHDC8B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    2. Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells. (PubMed id 19706467)1, 2 Salipante S.J.... Horwitz M.S. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. The kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability. (PubMed id 22988245)1 Krem M.M....Horwitz M.S. (J. Biol. Chem. 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    8. Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma. (PubMed id 20107318)1 Krem M.M....Horwitz M.S. (Cell Cycle 2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 200942 HGNC: 28557 AceView: MGC35097 Ensembl:ENSG00000185909 euGenes: HUgn200942
    ECgene: KLHDC8B H-InvDB: KLHDC8B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KLHDC8B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KLHDC8B gene:
    Search GeneIP for patents involving KLHDC8B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KLHDC8B   OriGene RNAi products in human, mouse, rat for KLHDC8B  
     OriGene qPCR primer pairs and template standards for KLHDC8B   OriGene Protein Over-expression Lysate for KLHDC8B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KLHDC8B  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLHDC8B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KLHDC8B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLHDC8B   OriGene Custom Protein Services for KLHDC8B  

     
     
     Block miRNA regulation of human, mouse, rat KLHDC8B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLHDC8B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHDC8B Predesigned siRNA for gene silencing in human, mouse, rat KLHDC8B
     QuantiFast Probe-based Assays in human, mouse, rat KLHDC8B QuantiTect SYBR Green Assays in human, mouse, rat KLHDC8B
     Custom PCR Arrays for KLHDC8B Search Chromatin IP Primers for KLHDC8B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHDC8B  Search GeneGlobe Interaction Network for KLHDC8B
     Regulatory tfbs in KLHDC8B promoter
     GenScript Custom Purified and Recombinant Proteins Services for KLHDC8B GenScript cDNA clones with any tag delivered in your preferred vector for KLHDC8B
     GenScript Custom Assay Services for KLHDC8B GenScript Custom overexpressing Cell Line Services for KLHDC8B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KLHDC8B (KLD8B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KLHDC8B antibodies
     KLHDC8B lysates
     Antibodies for KLHDC8B
     See all of Abcam's Antibodies, Kits and Proteins for KLHDC8B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KLHDC8B
     Antibodies for KLHDC8B
     ELISAs for KLHDC8B
     CLIAs for KLHDC8B



     Browse ESI BIO Cell Lines and PureStem Progenitors for KLHDC8B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC8B
     SwitchGear 3'UTR luciferase reporter plasmids for KLHDC8B
     SwitchGear Promoter luciferase reporter plasmids for KLHDC8B
     Search ThermoFisher Antibodies for KLHDC8B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC8B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHDC8B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLHDC8B
     LSBio Antibodies in human, mouse, rat for KLHDC8B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for KLHDC8B
      Search eBioscience for proteins for KLHDC8B
      Search eBioscience for elisas for KLHDC8B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLHDC8B gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4