Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLHDC8A Gene

protein-coding   GIFtS: 44
GCID: GC01M205305

kelch domain containing 8A

 Explore 1 disease affiliated with
KLHDC8A via our new
 Human Malady Compendium 
Biological research products
for KLHDC8A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Kelch Domain Containing 8A1 2
Substitute For Delta-EGFR Expression 12 3
S-Delta-E11
FLJ107481
Kelch Domain-Containing Protein 8A2

External Ids:    HGNC: 255731   Entrez Gene: 552202   Ensembl: ENSG000001628737   OMIM: 6145035   UniProtKB: Q8IYD23   

Export aliases for KLHDC8A gene to outside databases

Previous GC identifers: GC01M202038 GC01M203571 GC01M176471


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLHDC8A:
This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the
encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal
growth factor receptor dependence. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Dec 2012)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLHDC8A gene promoter:
         HOXA9B   HOXA9   Nkx2-2   GCNF   Meis-1b   Nkx6-1   GCNF-1   GCNF-2   LyF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHDC8A promoter sequence
   Search SABiosciences Chromatin IP Primers for KLHDC8A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHDC8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

KLHDC8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHDC8A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205305:  view genomic region     (about GC identifiers)

Start:
205,305,220 bp from pter      End:
205,326,166 bp from pter
Size:
20,947 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLD8A_HUMAN, Q8IYD2 (See protein sequence)
Recommended Name: Kelch domain-containing protein 8A  
Size: 350 amino acids; 38859 Da
Secondary accessions: B3KU70 Q9NVG5

Explore the universe of human proteins at neXtProt for KLHDC8A: NX_Q8IYD2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IYD2

  • KLHDC8A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001258792.1  NP_001258793.1  NP_001258794.1  NP_060673.1  

    ENSEMBL proteins: 
     ENSP00000356123   ENSP00000356124   ENSP00000443447   ENSP00000442229  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: KLHDC8A
    OriGene Custom Protein Services for KLHDC8A 
    GenScript Custom Purified and Recombinant Proteins Services for KLHDC8A
    Novus Biologicals KLHDC8A Protein
    Novus Biologicals KLHDC8A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KLHDC8A


    KLHDC8A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLHDC8A 
    GenScript Custom Superior Antibodies Services for KLHDC8A
    Novus Biologicals KLHDC8A Antibodies
    Search for Antibodies for KLHDC8A at Abcam  
    Uscn Antibodies for KLHDC8A
    Search ThermoFisher Antibodies for KLHDC8A

    Assay Products for KLHDC8A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLHDC8A
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KLHDC8A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KLHDC8A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006652 Kelch_1
     IPR015915 Kelch-typ_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q8IYD2

    ProtoNet protein and cluster: Q8IYD2

    1 Blocks protein family: IPB006651 Kelch repeat signature

    UniProtKB/Swiss-Prot: KLD8A_HUMAN, Q8IYD2
    Similarity: Contains 7 Kelch repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: KLHDC8A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHDC8A
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHDC8A (see all 14):
    hsa-miR-301b hsa-miR-4289 hsa-miR-876-5p hsa-miR-128 hsa-miR-3681* hsa-miR-301a hsa-miR-218 hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidKLHDC8A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHDC8A (see all 4)
    OriGene shRNA RFP: KLHDC8A
    OriGene siRNA: KLHDC8A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHDC8A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLHDC8A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC8A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC8A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KLHDC8A (NM_018203)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHDC8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC8A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLHDC8A
    Search LifeMap BioReagents cell lines for KLHDC8A

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC8A

    1 GenomeRNAi human phenotype for KLHDC8A:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHDC8A

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KLHDC8A (ENSP000003561234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC7ENSP000000800594STRING: ENSP00000080059
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLHDC8A
    Search CenterWatch for drugs/clinical trials and news about KLHDC8A / KLD8A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLHDC8A gene (4 alternative transcripts): 
    NM_001271863.1  NM_001271864.1  NM_001271865.1  NM_018203.2  

    Unigene Cluster for KLHDC8A:

    Kelch domain containing 8A
    Hs.10414  [show with all ESTs]
    Unigene Representative Sequence: NM_001271863
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367155(uc001hcf.1 uc010prg.1) ENST00000367156(uc001hcg.1)
    ENST00000460687 ENST00000491471 ENST00000537168 ENST00000539253

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: KLHDC8A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLHDC8A
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate KLHDC8A (see all 14):
    hsa-miR-301b hsa-miR-4289 hsa-miR-876-5p hsa-miR-128 hsa-miR-3681* hsa-miR-301a hsa-miR-218 hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidKLHDC8A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHDC8A (see all 4)
    OriGene shRNA RFP: KLHDC8A
    OriGene siRNA: KLHDC8A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHDC8A
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC8A (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC8A
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KLHDC8A (NM_018203)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHDC8A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC8A 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHDC8A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHDC8A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHDC8A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHDC8A

    Additional cDNA sequence: 

    AK001610.1 AK096590.1 AK299227.1 BC036076.1 

    8 DOTS entries:

    DT.412212  DT.100017397  DT.100685343  DT.100713874  DT.121454981  DT.92425906  DT.100751652  DT.121454985 

    24/80 AceView cDNA sequences (see all 80):

    CB141613 R56283 AW139401 Z39616 AA908205 CB054762 CR593027 BE220757 
    BM716664 AI918283 BF447914 AL519859 F08992 F08996 BF939563 CR618248 
    F11332 BM712830 AA738248 AU130999 AI457481 AA293895 F11336 AA398335 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLHDC8A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTGATGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    KLHDC8A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    BrainMidbrain tegmentumBrain
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KLHDC8A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLHDC8A

    SOURCE GeneReport for Unigene cluster: Hs.10414
        SABiosciences Custom PCR Arrays for KLHDC8A
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHDC8A
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHDC8A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHDC8A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHDC8A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC8A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLHDC8A gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves KLHDC8A1 kelch domain containing 8A 79.43(n)
    84.57(a)
      419829  XM_417963.3  XP_417963.3 
    lizard
    (Anolis carolinensis)
    Reptilia KLHDC8A6
    --
    83(a)
    1 ↔ 1
    4(115902973-115917775)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.1082 Transcribed sequence with moderate similarity to protein more 76.28(n)    BG348571.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7942581 kelch domain-containing protein 8A-like 60.73(n)
    56.03(a)
      794258  XM_001334158.3  XP_001334194.3 
    worm
    (Caenorhabditis elegans)
    Secernentea spe-266
    tag-1476
    (see all 7)
    Spermatocyte protein spe-26
    Temporarily Assigned Gene name family member (tag-...
    (see all 7)
    9(a)
    7(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    IV(10389556-10391924)
    X(12624588-12634286)


    ENSEMBL Gene Tree for KLHDC8A (if available)
    TreeFam Gene Tree for KLHDC8A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLHDC8A gene
    KLHDC8B2  IVNS1ABP2  
    1 SIMAP similar gene for KLHDC8A using alignment to 2 protein entries:     KLD8A_HUMAN (see all proteins):
    KLHDC8B

    KLHDC8A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10 NCBI SNPs in KLHDC8A are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559626991,2
    C,F,--176486079(+) TTATCT/ATTGAA 1 -- int14Minor allele frequency- A:0.50WA CSA 8
    rs618241631,2
    --176486485(+) AGGTCT/GGGAGT 1 -- int11Minor allele frequency- G:0.00CSA 1
    rs1394982511,2
    C,--205311952(+) CCTGA-/GGACTTA
    GTGAAACGC
    GGCCA
    1 -- int10--------
    rs575910141,2
    C--205311954(+) TGAGG-/ACTTAGT
    GAAACGCGG
    CCAGA
    1 -- int11Minor allele frequency- ACTTAGTGAAACGCGG:0.00NA 2
    rs765131321,2
    --205311967(+) AAACGA/CGGCCA 1 -- int10--------
    rs580416711,2
    C--205319956(+) CATGCGTGTGTGTGT
    GTGCATGC
    /-
    ATGTG
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs599691761,2
    C,--205320730(+) ATAGT-/CAAAAAAA 1 -- int10--------
    rs715244831,2
    C--205320730(+) ATAGTA/CAAAAA 1 -- int11Minor allele frequency- C:0.00NA 2
    rs601222171,2
    ----205320730(+) ATAGT-/CAAAAAA 1 -- int10--------
    rs1996621581,2
    ----205311954(+) TGAGGA/CCTTAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for KLHDC8A (205305220 - 205326166 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KLHDC8A: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHDC8A
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHDC8A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KLHDC8A for disorders           About GeneDecksing

    OMIM gene information: 614503    OMIM disorders: --

    1 disease for KLHDC8A:    About MalaCards
    malaria


    Export disorders for KLHDC8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLHDC8A gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KLHDC8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    4. Mutant EGFR is required for maintenance of glioma gro wth in vivo, and its ablation leads to escape from receptor dependence. (PubMed id 20133782)1 Mukasa A....Furnari F. (2010)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55220 HGNC: 25573 AceView: FLJ10748 Ensembl:ENSG00000162873 euGenes: HUgn55220
    ECgene: KLHDC8A H-InvDB: KLHDC8A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLHDC8A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLHDC8A gene:
    Search GeneIP for patents involving KLHDC8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for KLHDC8A  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHDC8A   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHDC8A  
     OriGene Protein Over-expression Lysate for KLHDC8A   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KLHDC8A   OriGene 3'-UTR Clone for KLHDC8A  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC8A   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC8A  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLHDC8A   OriGene Custom Protein Services for KLHDC8A  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHDC8A
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHDC8A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHDC8A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHDC8A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHDC8A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHDC8A
     GenScript Custom Purified and Recombinant Proteins Services for KLHDC8A GenScript cDNA clones with any tag delivered in your preferred vector for KLHDC8A
     GenScript Custom Assay Services for KLHDC8A GenScript Custom Superior Antibodies Services for KLHDC8A
     GenScript Custom overexpressing Cell Line Services for KLHDC8A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLHDC8A promoter
     Search Chromatin IP Primers for KLHDC8A
     RT2 qPCR Primer Assay in human, mouse, rat KLHDC8A
     Search GNC Networks for KLHDC8A
     SABiosciences Custom PCR Arrays for KLHDC8A
     Search Tocris compounds for KLHDC8A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLHDC8A antibodies
     KLHDC8A proteins
     KLHDC8A lysates
     Search for Antibodies for KLHDC8A at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KLHDC8A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KLHDC8A Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KLHDC8A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC8A
     SwitchGear 3'UTR luciferase reporter plasmids for KLHDC8A
     SwitchGear Promoter luciferase reporter plasmids for KLHDC8A
     Search ThermoFisher Antibodies for KLHDC8A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC8A
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLHDC8A gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4