KLHDC8A Gene
protein-coding GIFtS : 44
GCID: GC01 M205305
kelch domain containing 8A
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Aliasesfor KLHDC8A gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Kelch Domain Containing 8A 1 2 Substitute For Delta-EGFR Expression 12 3 S-Delta-E11 FLJ107481 Kelch Domain-Containing Protein 8A2
Export aliases for KLHDC8A gene to outside databases Previous GC identifers: GC01M202038 GC01M203571 GC01M176471
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Summariesfor KLHDC8A gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for KLHDC8A : This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor dependence. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2012)
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Genomic Viewsfor KLHDC8A gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004487.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KLHDC8A gene promoter: HOXA9B HOXA9 Nkx2-2 GCNF Meis-1b Nkx6-1 GCNF-1 GCNF-2 LyF-1 Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for KLHDC8A Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHDC8A
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1 KLHDC8A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M205305: view genomic region
(about GC identifiers )
Start:
205,305,220 bp from pter
End:
205,326,166 bp from pter
Size:
20,947 bases
Orientation:
minus strand
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Proteinsfor KLHDC8A gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KLD8A_HUMAN, Q8IYD2 (See
protein sequence )Recommended Name: Kelch domain-containing protein 8A Size : 350 amino acids; 38859 Da
Secondary accessions : B3KU70 Q9NVG5Explore the universe of human proteins at neXtProt for KLHDC8A: NX_Q8IYD2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8IYD2 KLHDC8A Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (4 alternative transcripts):
NP_001258792.1 NP_001258793.1 NP_001258794.1 NP_060673.1 ENSEMBL proteins: ENSP00000356123 ENSP00000356124 ENSP00000443447 ENSP00000442229 Human Recombinant Protein Products: KLHDC8A Antibody Products: Assay Products for KLHDC8A:
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Protein
Domains / Familiesfor KLHDC8A gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KLHDC8A for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8IYD2 ProtoNet protein and cluster: Q8IYD2
1 Blocks protein family : IPB006651 Kelch repeat signature UniProtKB/Swiss-Prot: KLD8A_HUMAN, Q8IYD2 Similarity : Contains 7 Kelch repeats
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Functionfor KLHDC8A gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLHDC8A (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLHDC8AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLHDC8A (NM_018203 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHDC8A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLHDC8A
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC8A
1 GenomeRNAi human phenotype for KLHDC8A :
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Pathways & Interactionsfor KLHDC8A gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHDC8A STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for KLHDC8A (ENSP00000356123 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor KLHDC8A gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KLHDC8A Search CenterWatch for drugs/clinical trials and news about KLHDC8A / KLD8A
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Transcriptsfor KLHDC8A gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KLHDC8A gene (4 alternative transcripts): NM_001271863.1 NM_001271864.1 NM_001271865.1 NM_018203.2 Unigene Cluster for KLHDC8A:
Kelch domain containing 8A Hs.10414 [show with all ESTs ] Unigene Representative Sequence: NM_001271863 6 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000367155 (uc001hcf.1 uc010prg.1 ) ENST00000367156 (uc001hcg.1 )ENST00000460687 ENST00000491471 ENST00000537168 ENST00000539253 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLHDC8A (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLHDC8AOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLHDC8A (NM_018203 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHDC8A Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLHDC8A
Additional cDNA sequence: AK001610.1 AK096590.1 AK299227.1 BC036076.1
8 DOTS entries : DT.412212 DT.100017397
DT.100685343 DT.100713874 DT.121454981 DT.92425906 DT.100751652 DT.121454985 24/80 AceView cDNA sequences (see all 80 ):
CB141613 R56283 AW139401 Z39616 AA908205 CB054762 CR593027 BE220757 BM716664 AI918283 BF447914 AL519859 F08992 F08996 BF939563 CR618248 F11332 BM712830 AA738248 AU130999 AI457481 AA293895 F11336 AA398335 GeneLoc Exon Structure
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Expression for KLHDC8A gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KLHDC8A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGTGATGGGG
About this image KLHDC8A expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See KLHDC8A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KLHDC8A SOURCE GeneReport for Unigene cluster: Hs.10414 SABiosciences Custom PCR Arrays for KLHDC8A Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KLHDC8ABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KLHDC8A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KLHDC8A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KLHDC8A In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC8A
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Orthologsfor KLHDC8A gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for KLHDC8A gene from 5/21 species (see all 21 ) About this table
ENSEMBL Gene Tree for KLHDC8A (if available)TreeFam Gene Tree for KLHDC8A (if available)
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Paralogsfor KLHDC8A gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KLHDC8A gene KLHDC8B 2 IVNS1ABP 2 1 SIMAP similar gene for KLHDC8A using alignment to 2 protein entries: KLD8A_HUMAN (see all proteins ):KLHDC8B
KLHDC8A for paralogs About GeneDecksing
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Genomic Variantsfor KLHDC8A gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for KLHDC8A (205305220 - 205326166 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for KLHDC8A: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KLHDC8A
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Disorders
/ Diseasesfor KLHDC8A gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
KLHDC8A for disorders About GeneDecksing
OMIM gene information: 614503
OMIM disorders : --1 disease for KLHDC8A : About MalaCards malaria Export disorders for KLHDC8A gene to outside databases
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Publicationsfor KLHDC8A gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KLHDC8A gene integrated from 9 sources : (articles sorted by number of sources associating them with KLHDC8A) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606) 1 Lin Y.Y....Boeke J.D. (2012) Mutant EGFR is required for maintenance of glioma gro wth in vivo, and its ablation leads to escape from receptor dependence. (PubMed id 20133782) 1 Mukasa A....Furnari F. (2010) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 2 Gregory S.G.... Bentley D.R. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for KLHDC8A gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KLHDC8A gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KLHDC8A gene
(According to HUGE )
About This Section --
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Specialized Databases showing KLHDC8A gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KLHDC8A Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KLHDC8A gene: Search GeneIP for patents involving KLHDC8A GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KLHDC8A gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KLHDC8A OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KLHDC8A OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KLHDC8A OriGene Protein Over-expression Lysate for KLHDC8A Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KLHDC8A OriGene 3'-UTR Clone for KLHDC8A OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLHDC8A OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLHDC8A Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KLHDC8A OriGene Custom Protein Services for KLHDC8A OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHDC8A QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KLHDC8A QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHDC8A QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KLHDC8A QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KLHDC8A QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KLHDC8A
Search Tocris compounds for KLHDC8A
KLHDC8A Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC8A
Search ThermoFisher Antibodies for KLHDC8A
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLHDC8A
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Domains / Families for KLHDC8A
Drugs / Compounds for KLHDC8A
Expression for KLHDC8A
Function for KLHDC8A
Genomic Views for KLHDC8A
Intellectual Property for KLHDC8A
Orthologs for KLHDC8A
Paralogs for KLHDC8A
Pathways / Interactions for KLHDC8A
Products for KLHDC8A
Proteins for KLHDC8A
Publications for KLHDC8A
Search Box for KLHDC8A
Summaries for KLHDC8A
Transcripts for KLHDC8A
Variants for KLHDC8A
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