KLHDC7B Gene
protein-coding GIFtS: 39
GCID: GC22P050986
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|
kelch domain containing 7B
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Aliases
for KLHDC7B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch Domain Containing 7B1 2 | | MGC166351 | | Kelch Domain-Containing Protein 7B2 |
Export aliases for KLHDC7B gene to outside databasesPrevious GC identifers: GC22P049277 GC22P049333 GC22P033877 |
Summaries
for KLHDC7B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLHDC7B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011526.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHDC7B gene promoter:
Sp1 Brachyury MIF-1 RORalpha2 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHDC7B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHDC7B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33 HGNC cytogenetic band: 22q13.33KLHDC7B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P050986: view genomic region
(about GC identifiers)
Start:
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50,986,462 bp from pter |
End:
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50,989,452 bp from pter |
Size:
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2,991 bases |
Orientation:
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plus strand |
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Proteins
for KLHDC7B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLD7B_HUMAN, Q96G42 (See
protein sequence)Recommended Name: Kelch domain-containing protein 7B Size: 594 amino acids; 63314 Da
Caution: It is uncertain whether Met-1 or Met-100 is the initiator
Sequence caution: Sequence=AAH09980.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Explore the universe of human proteins at neXtProt for KLHDC7B: NX_Q96G42
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96G42
KLHDC7B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612442.2
ENSEMBL proteins: ENSP00000379034
Human Recombinant Protein Products for KLHDC7B:
KLHDC7B Antibody Products:
Assay Products for KLHDC7B: |
Protein
Domains /
Families
for KLHDC7B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHDC7B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96G42ProtoNet protein and cluster: Q96G42 UniProtKB/Swiss-Prot: KLD7B_HUMAN, Q96G42Similarity: Contains 5 Kelch repeats |
Function
for KLHDC7B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for KLHDC7B:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLHDC7B (NM_138433) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHDC7B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC7B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC7B |
|
Pathways & Interactions
for KLHDC7B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHDC7B
|
Drugs & Compounds
for KLHDC7B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHDC7B
Search CenterWatch for drugs/clinical trials and news about KLHDC7B / KLD7B
|
Transcripts
for KLHDC7B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHDC7B gene: NM_138433.3 Unigene Cluster for KLHDC7B: Kelch domain containing 7B Hs.137007 [show with all ESTs]Unigene Representative Sequence: NM_1384331 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000395676(uc003bmi.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7B (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHDC7B (NM_138433) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHDC7B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC7B |
Additional cDNA sequence: BC009980.2 2 DOTS entries: DT.100021571 DT.40249922 24/28 AceView cDNA sequences (see all 28): AI631846 BC009980 BX089801 AI272025 BI910665 CN479146 NM_138433 BQ278699 BU537962 BU944606 AW170304 AW794185 AA854620 BU538676 BU944627 BU537910 BU557985 BQ279016 BI759479 BU858268 BU538452 BI060599 BU858006 BQ072748
GeneLoc Exon Structure
|
Expression
for KLHDC7B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHDC7B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KLHDC7B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHDC7B
SOURCE GeneReport for Unigene cluster: Hs.137007
SABiosciences Custom PCR Arrays for KLHDC7B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHDC7B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHDC7B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHDC7B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHDC7B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC7B |
Orthologs
for KLHDC7B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KLHDC7B gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG18126 |
-- |
13(a) |
1 → many |
X(20382574-20386859) |
ENSEMBL Gene Tree for KLHDC7B (if available)
TreeFam Gene Tree for KLHDC7B (if available) |
Paralogs
for KLHDC7B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHDC7B gene
- KLHL422 KLHL132 KLHL222 KLHL262 KLHL342 KBTBD132 KBTBD112 KLHL312
- KLHL92 KLHL322 KLHL142 KLHL152 KLHL362 KLHL332 KLHDC7A2
2 SIMAP similar genes for KLHDC7B using alignment to 1 protein entry: KLD7B_HUMAN:KBTBD11 KLHDC7A
KLHDC7B for paralogs About GeneDecksing
|
Genomic Variants
for KLHDC7B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHDC7B (50986462 - 50989452 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for KLHDC7B
2 CNVs: 4139 5192 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for KLHDC7B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLHDC7B for disorders About GeneDecksing
1  disease for KLHDC7B: About MalaCardsbreast cancer
Export disorders for KLHDC7B gene to outside databases
|
Publications
for KLHDC7B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHDC7B gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHDC7B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Hs.137007 is a novel epigenetic marker hypermethylate d and up-regulated in breast cancer. (PubMed id 20372783)1 Kim T.W....Kim S.J. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for KLHDC7B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLHDC7B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHDC7B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHDC7B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHDC7B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLHDC7B gene:
Search GeneIP for patents involving KLHDC7B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHDC7B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLHDC7B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHDC7B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHDC7B | | | OriGene Protein Over-expression Lysate for KLHDC7B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLHDC7B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for KLHDC7B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHDC7B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHDC7B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHDC7B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHDC7B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHDC7B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHDC7B |
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| | | | Search Tocris compounds for KLHDC7B |
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 | | | KLHDC7B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC7B |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KLHDC7B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC7B |
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