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Aliases for KLHDC7B Gene

Aliases for KLHDC7B Gene

  • Kelch Domain Containing 7B 2 3

External Ids for KLHDC7B Gene

Previous GeneCards Identifiers for KLHDC7B Gene

  • GC22P049277
  • GC22P049333
  • GC22P050986
  • GC22P033877

Summaries for KLHDC7B Gene

GeneCards Summary for KLHDC7B Gene

KLHDC7B (Kelch Domain Containing 7B) is a Protein Coding gene. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC7B Gene

Genomics for KLHDC7B Gene

Regulatory Elements for KLHDC7B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHDC7B Gene

Chromosome:
22
Start:
50,548,033 bp from pter
End:
50,551,023 bp from pter
Size:
2,991 bases
Orientation:
Plus strand

Genomic View for KLHDC7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHDC7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC7B Gene

Proteins for KLHDC7B Gene

  • Protein details for KLHDC7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G42-KLD7B_HUMAN
    Recommended name:
    Kelch domain-containing protein 7B
    Protein Accession:
    Q96G42

    Protein attributes for KLHDC7B Gene

    Size:
    594 amino acids
    Molecular mass:
    63314 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH09980.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for KLHDC7B Gene

Proteomics data for KLHDC7B Gene at MOPED

Post-translational modifications for KLHDC7B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHDC7B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC7B Gene

Domains & Families for KLHDC7B Gene

Protein Domains for KLHDC7B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLHDC7B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G42

UniProtKB/Swiss-Prot:

KLD7B_HUMAN :
  • Contains 5 Kelch repeats.
Similarity:
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KLHDC7B: view

No data available for Gene Families for KLHDC7B Gene

Function for KLHDC7B Gene

Gene Ontology (GO) - Molecular Function for KLHDC7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHDC7B: view

Phenotypes for KLHDC7B Gene

genes like me logo Genes that share phenotypes with KLHDC7B: view

Animal Model Products

CRISPR Products

miRNA for KLHDC7B Gene

miRTarBase miRNAs that target KLHDC7B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHDC7B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC7B Gene

Localization for KLHDC7B Gene

Gene Ontology (GO) - Cellular Components for KLHDC7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031463 Cul3-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with KLHDC7B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for KLHDC7B Gene

Pathways & Interactions for KLHDC7B Gene

SuperPathways for KLHDC7B Gene

No Data Available

Interacting Proteins for KLHDC7B Gene

Gene Ontology (GO) - Biological Process for KLHDC7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
genes like me logo Genes that share ontologies with KLHDC7B: view

No data available for Pathways by source and SIGNOR curated interactions for KLHDC7B Gene

Drugs & Compounds for KLHDC7B Gene

No Compound Related Data Available

Transcripts for KLHDC7B Gene

mRNA/cDNA for KLHDC7B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLHDC7B Gene

Kelch domain containing 7B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHDC7B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC7B Gene

No ASD Table

Relevant External Links for KLHDC7B Gene

GeneLoc Exon Structure for
KLHDC7B
ECgene alternative splicing isoforms for
KLHDC7B

Expression for KLHDC7B Gene

mRNA expression in normal human tissues for KLHDC7B Gene

mRNA differential expression in normal tissues according to GTEx for KLHDC7B Gene

This gene is overexpressed in Whole Blood (x8.0), Spleen (x6.9), and Kidney - Cortex (x5.6).

SOURCE GeneReport for Unigene cluster for KLHDC7B Gene Hs.137007

genes like me logo Genes that share expression patterns with KLHDC7B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KLHDC7B Gene

Orthologs for KLHDC7B Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHDC7B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLHDC7B 35
  • 79.43 (n)
  • 72.79 (a)
KLHDC7B 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhdc7b 35
  • 75.59 (n)
  • 72.37 (a)
Klhdc7b 16
Klhdc7b 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLHDC7B 35
  • 98.76 (n)
  • 97.44 (a)
rat
(Rattus norvegicus)
Mammalia Klhdc7b 35
  • 76.05 (n)
  • 73.38 (a)
oppossum
(Monodelphis domestica)
Mammalia KLHDC7B 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHDC7B 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc7b 35
  • 51.97 (n)
  • 46.83 (a)
Species with no ortholog for KLHDC7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLHDC7B Gene

ENSEMBL:
Gene Tree for KLHDC7B (if available)
TreeFam:
Gene Tree for KLHDC7B (if available)

Paralogs for KLHDC7B Gene

(2) SIMAP similar genes for KLHDC7B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLHDC7B: view

Variants for KLHDC7B Gene

Sequence variations from dbSNP and Humsavar for KLHDC7B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs131779 -- 50,549,764(-) TGCAG(C/T)GCAGT reference, missense
rs140519 -- 50,549,633(-) AGTGC(A/C)ACGAT reference, synonymous-codon
rs4575819 -- 50,547,931(+) agccc(C/T)aaccc upstream-variant-2KB
rs5770881 -- 50,546,840(+) TCCTC(C/T)CGCCA upstream-variant-2KB
rs5770882 -- 50,547,274(+) CCCAG(A/G)CTCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLHDC7B Gene

Variant ID Type Subtype PubMed ID
nsv915495 CNV Loss 21882294
nsv914525 CNV Loss 21882294
dgv5062n71 CNV Loss 21882294
nsv834238 CNV Loss 17160897
nsv471224 CNV Loss 18288195
nsv914542 CNV Loss 21882294
nsv914543 CNV Loss 21882294
dgv5065n71 CNV Loss 21882294
nsv834239 CNV Loss 17160897
dgv1422e1 CNV Complex 17122850
dgv5066n71 CNV Loss 21882294
nsv914554 CNV Loss 21882294
nsv829340 CNV Gain 20364138
dgv5067n71 CNV Loss 21882294
nsv914556 CNV Loss 21882294
nsv914559 CNV Loss 21882294

Variation tolerance for KLHDC7B Gene

Gene Damage Index Score: 11.88; 93.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLHDC7B Gene

HapMap Linkage Disequilibrium report
KLHDC7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC7B Gene

Disorders for KLHDC7B Gene

Relevant External Links for KLHDC7B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLHDC7B
genes like me logo Genes that share disorders with KLHDC7B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC7B Gene

Publications for KLHDC7B Gene

  1. Hs.137007 is a novel epigenetic marker hypermethylated and up-regulated in breast cancer. (PMID: 20372783) Kim T.W. … Kim S.J. (Int. J. Oncol. 2010) 67
  2. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 67

Products for KLHDC7B Gene

Sources for KLHDC7B Gene

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