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Aliases for KLHDC7A Gene

Aliases for KLHDC7A Gene

  • Kelch Domain Containing 7A 2 3

External Ids for KLHDC7A Gene

Summaries for KLHDC7A Gene

GeneCards Summary for KLHDC7A Gene

KLHDC7A (Kelch Domain Containing 7A) is a Protein Coding gene. An important paralog of this gene is KLHL36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC7A Gene

Genomics for KLHDC7A Gene

Genomic Location for KLHDC7A Gene

Start:
18,480,930 bp from pter
End:
18,486,126 bp from pter
Size:
5,197 bases
Orientation:
Plus strand

Genomic View for KLHDC7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHDC7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC7A Gene

Regulatory Elements for KLHDC7A Gene

Proteins for KLHDC7A Gene

  • Protein details for KLHDC7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTJ3-KLD7A_HUMAN
    Recommended name:
    Kelch domain-containing protein 7A
    Protein Accession:
    Q5VTJ3
    Secondary Accessions:
    • Q8N8W6

    Protein attributes for KLHDC7A Gene

    Size:
    777 amino acids
    Molecular mass:
    84479 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04695.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH73690.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KLHDC7A Gene

Proteomics data for KLHDC7A Gene at MOPED

Post-translational modifications for KLHDC7A Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn257

Other Protein References for KLHDC7A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC7A Gene

Domains for KLHDC7A Gene

Protein Domains for KLHDC7A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KLD7A_HUMAN
Similarity:
  • Contains 5 Kelch repeats.:
    • Q5VTJ3
genes like me logo Genes that share domains with KLHDC7A: view

No data available for Gene Families for KLHDC7A Gene

Function for KLHDC7A Gene

Gene Ontology (GO) - Molecular Function for KLHDC7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHDC7A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLHDC7A Gene

Localization for KLHDC7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC7A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHDC7A Gene COMPARTMENTS Subcellular localization image for KLHDC7A gene
Compartment Confidence
extracellular 2
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLHDC7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KLHDC7A: view

Pathways for KLHDC7A Gene

SuperPathways for KLHDC7A Gene

No Data Available

Interacting Proteins for KLHDC7A Gene

Gene Ontology (GO) - Biological Process for KLHDC7A Gene

None

No data available for Pathways by source for KLHDC7A Gene

Transcripts for KLHDC7A Gene

mRNA/cDNA for KLHDC7A Gene

(1) REFSEQ mRNAs :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC7A Gene

No ASD Table

Relevant External Links for KLHDC7A Gene

GeneLoc Exon Structure for
KLHDC7A
ECgene alternative splicing isoforms for
KLHDC7A

Expression for KLHDC7A Gene

mRNA expression in normal human tissues for KLHDC7A Gene

mRNA differential expression in normal tissues according to GTEx for KLHDC7A Gene

This gene is overexpressed in Kidney - Cortex (23.2) and Liver (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHDC7A Gene

SOURCE GeneReport for Unigene cluster for KLHDC7A Gene Hs.406913

genes like me logo Genes that share expressions with KLHDC7A: view

Orthologs for KLHDC7A Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLHDC7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHDC7A 36
  • 98.24 (n)
  • 97.04 (a)
KLHDC7A 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHDC7A 36
  • 78.69 (n)
  • 69.46 (a)
KLHDC7A 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHDC7A 36
  • 79.62 (n)
  • 71.41 (a)
KLHDC7A 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhdc7a 36
  • 76.51 (n)
  • 70.22 (a)
Klhdc7a 16
Klhdc7a 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHDC7A 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHDC7A 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhdc7a 36
  • 77.42 (n)
  • 71 (a)
chicken
(Gallus gallus)
Aves KLHDC7A 36
  • 57.6 (n)
  • 50.88 (a)
KLHDC7A 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHDC7A 37
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC799728 36
  • 50.51 (n)
  • 44.2 (a)
Species with no ortholog for KLHDC7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHDC7A Gene

ENSEMBL:
Gene Tree for KLHDC7A (if available)
TreeFam:
Gene Tree for KLHDC7A (if available)

Paralogs for KLHDC7A Gene

Selected SIMAP similar genes for KLHDC7A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KLHDC7A: view

Variants for KLHDC7A Gene

Sequence variations from dbSNP and Humsavar for KLHDC7A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs708088 -- 18,485,822(-) GCTAC(A/G)GGTTC utr-variant-3-prime
rs872355 -- 18,485,682(+) TCAGG(A/G)TGGAA utr-variant-3-prime
rs1360918 -- 18,479,494(-) CCCTA(C/T)GCCGA upstream-variant-2KB
rs1360919 -- 18,479,350(-) TGGGT(A/G)AAAGG upstream-variant-2KB
rs1360920 -- 18,479,204(-) ATCTG(A/G)TCTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLHDC7A Gene

Variant ID Type Subtype PubMed ID
nsv834336 CNV Loss 17160897
nsv871296 CNV Gain 21882294

Relevant External Links for KLHDC7A Gene

HapMap Linkage Disequilibrium report
KLHDC7A

Disorders for KLHDC7A Gene

Relevant External Links for KLHDC7A

Genetic Association Database (GAD)
KLHDC7A
Human Genome Epidemiology (HuGE) Navigator
KLHDC7A
genes like me logo Genes that share disorders with KLHDC7A: view

No data available for UniProtKB/Swiss-Prot for KLHDC7A Gene

Publications for KLHDC7A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Genome-wide meta-analysis for severe diabetic retinopathy. (PMID: 21441570) Grassi M.A. … Nicolae D.L. (Hum. Mol. Genet. 2011) 3
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4

Products for KLHDC7A Gene

Sources for KLHDC7A Gene

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