KLHDC7A Gene
protein-coding GIFtS: 36
GCID: GC01P018807
|
|
kelch domain containing 7A
| |
Aliases
for KLHDC7A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch Domain Containing 7A1 2 | | FLJ387531 | | RP11-422P22.22 | | Kelch Domain-Containing Protein 7A2 |
Export aliases for KLHDC7A gene to outside databasesPrevious GC identifers: GC01P018554 GC01P018680 GC01P017055 |
Summaries
for KLHDC7A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLHDC7A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHDC7A gene promoter:
SRF AhR NF-1 SRF (504 AA) AP-4 Arnt AREB6 PPAR-alpha MZF-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHDC7A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHDC7A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13KLHDC7A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P018807: view genomic region
(about GC identifiers)
Start:
|
18,807,424 bp from pter |
End:
|
18,812,493 bp from pter |
Size:
|
5,070 bases |
Orientation:
|
plus strand |
|
Proteins
for KLHDC7A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLD7A_HUMAN, Q5VTJ3 (See
protein sequence)Recommended Name: Kelch domain-containing protein 7A Size: 777 amino acids; 84479 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAC04695.1; Type=Erroneous initiation; Sequence=CAH73690.2; Type=Erroneous initiation;
Secondary accessions: Q8N8W6Explore the universe of human proteins at neXtProt for KLHDC7A: NX_Q5VTJ3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VTJ3
KLHDC7A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689588.2
ENSEMBL proteins: ENSP00000383505
Human Recombinant Protein Products for KLHDC7A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
KLHDC7A for ontologies About GeneDecksing
KLHDC7A Antibody Products:
Assay Products for KLHDC7A: |
Protein
Domains /
Families
for KLHDC7A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHDC7A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VTJ3ProtoNet protein and cluster: Q5VTJ3 UniProtKB/Swiss-Prot: KLD7A_HUMAN, Q5VTJ3Similarity: Contains 5 Kelch repeats |
Function
for KLHDC7A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLHDC7A (NM_152375) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHDC7A | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KLHDC7A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC7A |
|
Pathways & Interactions
for KLHDC7A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHDC7A
|
Drugs & Compounds
for KLHDC7A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHDC7A
Search CenterWatch for drugs/clinical trials and news about KLHDC7A / KLD7A
|
Transcripts
for KLHDC7A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHDC7A gene: NM_152375.2 Unigene Clusters for KLHDC7A: Kelch domain containing 7A Hs.406913 [show with all ESTs], Hs.710799 [show with all ESTs]Unigene Representative Sequences: NM_152375, BC1512051 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000400664(uc001bax.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHDC7A (NM_152375) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHDC7A | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KLHDC7A |
Additional cDNA sequence: BC151205.1 1 DOTS entry: DT.40118808 18 AceView cDNA sequences: AW299244 AI084830 AI792005 BM976939 NM_152375 AA989406 BE170473 AK096072 BU684635 CA503355 AI820608 AI609332 AI800235 AK056173 AI928476 AW614109 AA340756 CD637795
GeneLoc Exon Structure
|
Expression
for KLHDC7A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHDC7A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KLHDC7A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHDC7A
SOURCE GeneReport for Unigene clusters: Hs.406913 Hs.710799
SABiosciences Custom PCR Arrays for KLHDC7A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHDC7A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHDC7A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHDC7A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHDC7A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC7A |
Orthologs
for KLHDC7A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KLHDC7A gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for KLHDC7A (if available)
TreeFam Gene Tree for KLHDC7A (if available) |
Paralogs
for KLHDC7A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHDC7A gene
- KLHL422 KLHL132 KLHL222 KLHL262 KLHL342 KBTBD132 KBTBD112 KLHL312
- KLHL92 KLHL322 KLHL142 KLHDC7B2 KLHL152 KLHL362 KLHL332
1 SIMAP similar gene for KLHDC7A using alignment to 3 protein entries: KLD7A_HUMAN (see all proteins):KLHDC7B
KLHDC7A for paralogs About GeneDecksing
|
Genomic Variants
for KLHDC7A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHDC7A (18807424 - 18812493 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLHDC7A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHDC7A |
|
Disorders
/ Diseases
for KLHDC7A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 KLHDC7A for disorders About MalaCards
KLHDC7A for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: KLHDC7A (1 document)
Export disorders for KLHDC7A gene to outside databases
|
Publications
for KLHDC7A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHDC7A gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHDC7A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Genome-wide meta-analysis for severe diabetic retinop athy. (PubMed id 21441570)1 Grassi M.A....Nicolae D.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KLHDC7A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLHDC7A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHDC7A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLHDC7A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHDC7A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLHDC7A gene:
Search GeneIP for patents involving KLHDC7A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHDC7A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLHDC7A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHDC7A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHDC7A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLHDC7A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC7A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for KLHDC7A | | OriGene Custom Protein Services for KLHDC7A | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLHDC7A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHDC7A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHDC7A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLHDC7A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHDC7A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHDC7A |
| |
 |  |  |  | |
| | | | Search Tocris compounds for KLHDC7A |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | KLHDC7A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC7A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for KLHDC7A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KLHDC7A |
| |  | |
|
|
|
