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Aliases for KLHDC4 Gene

Aliases for KLHDC4 Gene

  • Kelch Domain Containing 4 2 3

External Ids for KLHDC4 Gene

Previous GeneCards Identifiers for KLHDC4 Gene

  • GC00U916984
  • GC16M086298
  • GC16M073482

Summaries for KLHDC4 Gene

GeneCards Summary for KLHDC4 Gene

KLHDC4 (Kelch Domain Containing 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC4 Gene

Genomics for KLHDC4 Gene

Regulatory Elements for KLHDC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHDC4 Gene

Start:
87,696,485 bp from pter
End:
87,765,997 bp from pter
Size:
69,513 bases
Orientation:
Minus strand

Genomic View for KLHDC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHDC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC4 Gene

Proteins for KLHDC4 Gene

  • Protein details for KLHDC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBB5-KLDC4_HUMAN
    Recommended name:
    Kelch domain-containing protein 4
    Protein Accession:
    Q8TBB5
    Secondary Accessions:
    • D3DUN3
    • D3DUN4
    • D3DUN5
    • Q96F29
    • Q9BVN3

    Protein attributes for KLHDC4 Gene

    Size:
    520 amino acids
    Molecular mass:
    57892 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLHDC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHDC4 Gene

Proteomics data for KLHDC4 Gene at MOPED

Post-translational modifications for KLHDC4 Gene

  • Ubiquitination at Lys252
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KLHDC4 Gene

Domains for KLHDC4 Gene

Protein Domains for KLHDC4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KLHDC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TBB5

UniProtKB/Swiss-Prot:

KLDC4_HUMAN :
  • Q8TBB5
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHDC4: view

No data available for Gene Families for KLHDC4 Gene

Function for KLHDC4 Gene

Gene Ontology (GO) - Molecular Function for KLHDC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with KLHDC4: view

Animal Model Products

CRISPR Products

miRNA for KLHDC4 Gene

miRTarBase miRNAs that target KLHDC4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHDC4 Gene

Localization for KLHDC4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHDC4 Gene COMPARTMENTS Subcellular localization image for KLHDC4 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KLHDC4 Gene

Pathways for KLHDC4 Gene

SuperPathways for KLHDC4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC4 Gene

None

No data available for Pathways by source for KLHDC4 Gene

Transcripts for KLHDC4 Gene

Unigene Clusters for KLHDC4 Gene

Kelch domain containing 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHDC4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KLHDC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - -
SP15: - - - - - - - -
SP16: - -
SP17: - - - - - - -
SP18: - - - - -
SP19: - - - - - - - - - - - - - -
SP20: - - - - - - -
SP21:
SP22: - - - -
SP23:
SP24:

ExUns: 11c · 11d · 11e ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: - - -
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11: - -
SP12: - - - -
SP13:
SP14:
SP15: -
SP16: - - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: - -

Relevant External Links for KLHDC4 Gene

GeneLoc Exon Structure for
KLHDC4
ECgene alternative splicing isoforms for
KLHDC4

Expression for KLHDC4 Gene

mRNA expression in normal human tissues for KLHDC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHDC4 Gene

SOURCE GeneReport for Unigene cluster for KLHDC4 Gene Hs.123450

genes like me logo Genes that share expressions with KLHDC4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHDC4 Gene

Orthologs for KLHDC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KLHDC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHDC4 35
  • 98.85 (n)
  • 98.27 (a)
KLHDC4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHDC4 35
  • 82.54 (n)
  • 83.02 (a)
KLHDC4 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHDC4 35
  • 81.9 (n)
  • 81.46 (a)
KLHDC4 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhdc4 35
  • 80.35 (n)
  • 80.28 (a)
Klhdc4 16
Klhdc4 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHDC4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHDC4 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLHDC4 35
  • 74.01 (n)
  • 76.19 (a)
KLHDC4 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHDC4 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53395 35
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc4 35
  • 68.53 (n)
  • 73.05 (a)
LOC394683 35
zebrafish
(Danio rerio)
Actinopterygii klhdc4 35
  • 68.33 (n)
  • 71.86 (a)
klhdc4 36
  • 62 (a)
OneToOne
wufb95f04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005007 35
  • 52.51 (n)
  • 42.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4069 35
  • 50.91 (n)
  • 42.01 (a)
CG4069 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEL3 36
  • 24 (a)
OneToOne
KEL3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G50310 35
  • 50.51 (n)
  • 41.07 (a)
rice
(Oryza sativa)
Liliopsida Os04g0483600 35
  • 48.89 (n)
  • 41.25 (a)
Species with no ortholog for KLHDC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHDC4 Gene

ENSEMBL:
Gene Tree for KLHDC4 (if available)
TreeFam:
Gene Tree for KLHDC4 (if available)

Paralogs for KLHDC4 Gene

Selected SIMAP similar genes for KLHDC4 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for KLHDC4 Gene

genes like me logo Genes that share paralogs with KLHDC4: view

No data available for Paralogs for KLHDC4 Gene

Variants for KLHDC4 Gene

Sequence variations from dbSNP and Humsavar for KLHDC4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs737637 -- 87,746,074(+) ACCTG(G/T)GCAAC intron-variant
rs746721 -- 87,727,693(-) TAATT(C/G)TGTCA intron-variant
rs746803 -- 87,746,895(-) TAAAC(A/G)GACAC intron-variant
rs888649 -- 87,746,701(-) TCACT(C/G)TCTTC intron-variant
rs1014628 -- 87,720,932(+) GAACC(G/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHDC4 Gene

Variant ID Type Subtype PubMed ID
nsv907153 CNV Loss 21882294
dgv2953n71 CNV Loss 21882294
dgv2954n71 CNV Loss 21882294
dgv2955n71 CNV Loss 21882294
nsv907177 CNV Loss 21882294
nsv907182 CNV Loss 21882294
dgv2956n71 CNV Loss 21882294
dgv2957n71 CNV Loss 21882294
dgv504n67 CNV Gain 20364138
nsv457616 CNV Gain 19166990
nsv833322 CNV Loss 17160897
esv28345 CNV Gain+Loss 19812545
esv993111 CNV Deletion 20482838
esv1590350 CNV Deletion 17803354
esv1006084 CNV Deletion 20482838
esv1228666 CNV Deletion 17803354
esv2714934 CNV Deletion 23290073
esv3822 CNV Deletion 18987735
esv2714935 CNV Deletion 23290073
esv2657033 CNV Deletion 23128226
esv1374631 CNV Deletion 17803354
esv2674128 CNV Deletion 23128226
nsv907194 CNV Loss 21882294

Relevant External Links for KLHDC4 Gene

HapMap Linkage Disequilibrium report
KLHDC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC4 Gene

Disorders for KLHDC4 Gene

Relevant External Links for KLHDC4

Genetic Association Database (GAD)
KLHDC4
genes like me logo Genes that share disorders with KLHDC4: view

No data available for UniProtKB/Swiss-Prot for KLHDC4 Gene

Publications for KLHDC4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Dystonia Overview (PMID: 20301334) Pagon R.A. … Stephens K. ( 1993) 3
  4. Huntington Disease-Like 2 (PMID: 20301701) Pagon R.A. … Stephens K. ( 1993) 3
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3

Products for KLHDC4 Gene

Sources for KLHDC4 Gene

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