Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KLHDC4 Gene

protein-coding   GIFtS: 50
GCID: GC16M087741

Kelch Domain Containing 4

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Kelch Domain Containing 41 2
Kelch Domain-Containing Protein 42

External Ids:    HGNC: 252721   Entrez Gene: 547582   Ensembl: ENSG000001047317   UniProtKB: Q8TBB53   

Export aliases for KLHDC4 gene to outside databases

Previous GC identifers: GC00U916984 GC16M086298 GC16M073482


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for KLHDC4 Gene:
KLHDC4 (kelch domain containing 4) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHDC4 gene promoter:
         SRF   AML1a   GCNF   SRF (504 AA)   FOXL1   POU2F1   POU2F1a   GCNF-1   GCNF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHDC4 promoter sequence
   Search Chromatin IP Primers for KLHDC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHDC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24

KLHDC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHDC4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M087741:  view genomic region     (about GC identifiers)

Start:
87,730,091 bp from pter      End:
87,799,598 bp from pter
Size:
69,508 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KLDC4_HUMAN, Q8TBB5 (See protein sequence)
Recommended Name: Kelch domain-containing protein 4  
Size: 520 amino acids; 57892 Da
Secondary accessions: D3DUN3 D3DUN4 D3DUN5 Q96F29 Q9BVN3
Alternative splicing: 3 isoforms:  Q8TBB5-1   Q8TBB5-2   Q8TBB5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLHDC4: NX_Q8TBB5

Explore proteomics data for KLHDC4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys252
  • Modification sites at PhosphoSitePlus

  • See KLHDC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171783.1  NP_001171785.1  NP_060036.2  

    ENSEMBL proteins: 
     ENSP00000457570   ENSP00000262530   ENSP00000325717   ENSP00000270583   ENSP00000455824  
     ENSP00000455780   ENSP00000455666   ENSP00000455214   ENSP00000457990   ENSP00000457098  
     ENSP00000454681   ENSP00000457857  

    KLHDC4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for KLHDC4
    OriGene Protein Over-expression Lysate for KLHDC4
    OriGene MassSpec for KLHDC4
    OriGene Custom Protein Services for KLHDC4
    GenScript Custom Purified and Recombinant Proteins Services for KLHDC4
    Novus Biologicals KLHDC4 Protein
    Novus Biologicals KLHDC4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLHDC4

     
    Search eBioscience for Proteins for KLHDC4 

     
    antibodies-online proteins for KLHDC4 (3 products) 

     
    antibodies-online peptides for KLHDC4

    KLHDC4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLHDC4
    Novus Biologicals KLHDC4 Antibodies
    Abcam antibodies for KLHDC4
    Cloud-Clone Corp. Antibodies for KLHDC4
    ThermoFisher Antibodies for KLHDC4
    antibodies-online antibodies for KLHDC4 (32 products) 

    KLHDC4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLHDC4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLHDC4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLHDC4
    Cloud-Clone Corp. CLIAs for KLHDC4
    Search eBioscience for ELISAs for KLHDC4 
    antibodies-online kits for KLHDC4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR011498 Kelch_2
     IPR015915 Kelch-typ_b-propeller

    Graphical View of Domain Structure for InterPro Entry Q8TBB5

    ProtoNet protein and cluster: Q8TBB5

    1 Blocks protein domain: IPB011498 Kelch

    UniProtKB/Swiss-Prot: KLDC4_HUMAN, Q8TBB5
    Similarity: Contains 6 Kelch repeats


    Find genes that share domains with KLHDC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with KLHDC4           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KLHDC4

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLHDC4:
    hsa-mir-1 (MIRT023572)

    Block miRNA regulation of human, mouse, rat KLHDC4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLHDC4
    SwitchGear 3'UTR luciferase reporter plasmidKLHDC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLHDC4
    Predesigned siRNA for gene silencing in human, mouse, rat KLHDC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLHDC4

    Clone
    Products:
         
    OriGene clones in human, mouse for KLHDC4 (see all 16)
    OriGene ORF clones in mouse, rat for KLHDC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): KLHDC4 (NM_017566)
    Sino Biological Human cDNA Clone for KLHDC4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHDC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLHDC4
    Browse ESI BIO Cell Lines and PureStem Progenitors for KLHDC4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHDC4
    Interactions:

        Search GeneGlobe Interaction Network for KLHDC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for KLHDC4 (Q8TBB51, 3 ENSP000002705834) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119403, ENSP000003130074I2D: score=2 STRING: ENSP00000313007
    PNO1Q9NRX13, ENSP000002636574I2D: score=4 STRING: ENSP00000263657
    PHBP352323, ENSP000003004084I2D: score=4 STRING: ENSP00000300408
    WDR1O750833I2D: score=5 
    DYNC1H1Q142043I2D: score=3 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLHDC4 (KLDC4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KLHDC4 gene (3 alternative transcripts): 
    NM_001184854.1  NM_001184856.1  NM_017566.3  

    Unigene Cluster for KLHDC4:

    Kelch domain containing 4
    Hs.123450  [show with all ESTs]
    Unigene Representative Sequence: AY251274
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000568444 ENST00000567298(uc002fkh.1) ENST00000568346 ENST00000568499
    ENST00000316853(uc010cht.2) ENST00000353170 ENST00000347925(uc002fkj.3)
    ENST00000566349 ENST00000270583(uc002fki.3 uc002fkl.3) ENST00000569487
    ENST00000562155 ENST00000562261 ENST00000566661(uc010chu.1) ENST00000562913
    ENST00000567513 ENST00000562872 ENST00000564484 ENST00000565328
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLHDC4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate KLHDC4
    SwitchGear 3'UTR luciferase reporter plasmidKLHDC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLHDC4
    Predesigned siRNA for gene silencing in human, mouse, rat KLHDC4
    Clone
    Products:
         
    OriGene clones in human, mouse for KLHDC4 (see all 16)
    OriGene ORF clones in mouse, rat for KLHDC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): KLHDC4 (NM_017566)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHDC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHDC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHDC4
      QuantiTect SYBR Green Assays in human, mouse, rat KLHDC4
      QuantiFast Probe-based Assays in human, mouse, rat KLHDC4

    Additional mRNA sequence: 

    AK001742.1 AK023986.1 AK024496.1 AK057211.1 AK092895.1 AK097097.1 AK098630.1 AL133107.1 
    AY251274.1 BC001044.2 BC011680.2 BC022969.1 

    21 DOTS entries:

    DT.91741629  DT.309421  DT.100036618  DT.91741634  DT.100036617  DT.95151206  DT.75148878  DT.100787895 
    DT.91675958  DT.120710349  DT.120710391  DT.92053471  DT.100787896  DT.101978603  DT.120710322  DT.120710347 
    DT.120710380  DT.120710382  DT.120710384  DT.91658278  DT.120710400 

    Selected AceView cDNA sequences (see all 190):

    BQ013761 BC022969 BG281965 AW088490 BG152666 BQ421078 CA392235 BM988049 
    BC011680 BP870449 BE407092 BM556502 CD721952 AI276461 BM760792 AL133107 
    BX096670 BM715028 AI160590 CR600527 BC001044 AX747795 AK092895 BM843663 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC4 (see all 24)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
    SP1:                                      -     -     -           -                 -     -                                               -     -     -         
    SP2:                                      -     -     -           -                 -     -                                               -     -     -     -   
    SP3:                                      -     -     -     -     -     -     -     -     -                                               -     -     -         
    SP4:                                                                                                                                            -     -         
    SP5:                                                                                                                                      -     -     -         

    ExUns: 11c · 11d · 11e ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17a · 17b ^ 18
    SP1:              -     -                                         -                 -               
    SP2:  -     -     -     -                                         -                 -               
    SP3:              -     -                                         -                 -               
    SP4:              -     -                                         -                 -               
    SP5:              -     -                                         -                                 


    ECgene alternative splicing isoforms for KLHDC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KLHDC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLHDC4 Expression
    About this image


    KLHDC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
    KLHDC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLHDC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.123450
        Custom PCR Arrays for KLHDC4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for KLHDC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHDC4
    QuantiTect SYBR Green Assays in human, mouse, rat KLHDC4
    QuantiFast Probe-based Assays in human, mouse, rat KLHDC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for KLHDC4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klhdc41 , 5 kelch domain containing 41, 5 80.35(n)1
    80.28(a)1
      8 (70.76 cM)5
    2348251  NM_145605.21  NP_663580.21 
     1217963135 
    chicken
    (Gallus gallus)
    Aves KLHDC41 kelch domain containing 4 74.01(n)
    76.19(a)
      415831  NM_001030578.1  NP_001025749.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLHDC46
    kelch domain containing 4
    52(a)
    1 ↔ 1
    GL344378.1(1384-11439)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC533952 hypothetical protein MGC53395 72.86(n)    BC043978.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb95f042 Transcribed sequence with weak similarity to protein more 77.64(n)    BQ617456.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40691 CG4069 50.91(n)
    42.01(a)
      39437  NM_140333.3  NP_648590.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KEL3(YPL263C)4 Cytoplasmic protein of unknown function   --   16(46506-44551) 855865  NP_015060.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G503101 AT5G50310 50.51(n)
    41.07(a)
      835096  NM_124410.3  NP_568723.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g04836001 Os04g0483600 48.89(n)
    41.25(a)
      4336203  NM_001059661.1  NP_001053126.1 


    ENSEMBL Gene Tree for KLHDC4 (if available)
    TreeFam Gene Tree for KLHDC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KLHDC4 gene
    1 SIMAP similar gene for KLHDC4 using alignment to 8 protein entries:     KLDC4_HUMAN (see all proteins):
    DKFZp434G0522

    Find genes that share paralogs with KLHDC4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KLHDC4
    PGOHUM00000246106


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KLHDC4 (see all 2356)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889575961,2
    --87740919(+) AGCCTC/GCCTTC 3 -- int10--------
    rs561680791,2
    C,F--87740930(+) CTGTCG/ACTTTG 3 -- int12Minor allele frequency- A:0.10WA 120
    rs1502244601,2
    --87740946(+) GCTAAA/TCCTAA 3 -- int10--------
    rs1929402411,2
    C--87740996(+) CCACAG/TCCTCC 3 -- int10--------
    rs1391683241,2
    --87741012(+) ACCACA/GCGGCG 3 -- int10--------
    rs1429805491,2
    --87741077(+) CCCCCA/GTGTGC 3 -- int10--------
    rs1474676981,2
    --87741116(+) AGAACC/TGGGAA 3 -- int10--------
    rs770168611,2
    C--87741168(+) AGAGGC/TTGATC 3 -- int14Minor allele frequency- T:0.13CSA WA NA EA 359
    rs1401876401,2
    --87741178(+) CCCAAC/GTGTGA 3 -- int10--------
    rs118595211,2
    C,F,H--87741225(+) CAGAAG/AGAAAG 3 -- int13Minor allele frequency- A:0.03NA WA 244

    HapMap Linkage Disequilibrium report for KLHDC4 (87730091 - 87799598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KLHDC4 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv993111CNV Deletion20482838
    esv1228666CNV Deletion17803354
    esv2657033CNV Deletion23128226
    esv1374631CNV Deletion17803354
    esv2714935CNV Deletion23290073
    esv1590350CNV Deletion17803354
    esv2714934CNV Deletion23290073
    esv2674128CNV Deletion23128226
    esv3822CNV Deletion18987735
    esv1006084CNV Deletion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLHDC4
    DNA2.0 Custom Variant and Variant Library Synthesis for KLHDC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with KLHDC4           About GenesLikeMe

    Genetic Association Database (GAD): KLHDC4

    Export disorders for KLHDC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KLHDC4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with KLHDC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    9. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (J. Proteome Res. 2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54758 HGNC: 25272 AceView: KLHDC4 Ensembl:ENSG00000104731 euGenes: HUgn54758
    ECgene: KLHDC4 H-InvDB: KLHDC4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KLHDC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KLHDC4 gene:
    Search GeneIP for patents involving KLHDC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for KLHDC4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for KLHDC4  
     OriGene MassSpec for KLHDC4   OriGene clones in human, mouse for KLHDC4  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLHDC4   OriGene Purified Protein for KLHDC4  
     OriGene ORF clones in mouse, rat for KLHDC4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLHDC4   OriGene Custom Protein Services for KLHDC4  

     
     
     Block miRNA regulation of human, mouse, rat KLHDC4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLHDC4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHDC4 Predesigned siRNA for gene silencing in human, mouse, rat KLHDC4
     QuantiFast Probe-based Assays in human, mouse, rat KLHDC4 QuantiTect SYBR Green Assays in human, mouse, rat KLHDC4
     Custom PCR Arrays for KLHDC4 Search Chromatin IP Primers for KLHDC4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHDC4  Search GeneGlobe Interaction Network for KLHDC4
     Regulatory tfbs in KLHDC4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KLHDC4 GenScript cDNA clones with any tag delivered in your preferred vector for KLHDC4
     GenScript Custom Assay Services for KLHDC4 GenScript Custom overexpressing Cell Line Services for KLHDC4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for KLHDC4 (KLDC4)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for KLHDC4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KLHDC4 antibodies
     KLHDC4 proteins
     KLHDC4 lysates
     Antibodies for KLHDC4
     See all of Abcam's Antibodies, Kits and Proteins for KLHDC4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KLHDC4
     Antibodies for KLHDC4
     ELISAs for KLHDC4
     CLIAs for KLHDC4



     Browse ESI BIO Cell Lines and PureStem Progenitors for KLHDC4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC4
     SwitchGear 3'UTR luciferase reporter plasmids for KLHDC4
     SwitchGear Promoter luciferase reporter plasmids for KLHDC4
     ThermoFisher Antibodies for KLHDC4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC4
     Browse compounds at ApexBio
     Search Addgene for plasmids for KLHDC4
      Search eBioscience for proteins for KLHDC4
      Search eBioscience for elisas for KLHDC4
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for KLHDC4
     antibodies-online antibodies for KLHDC4 (32 products)
     antibodies-online kits for KLHDC4 (4 products)
     antibodies-online peptides for KLHDC4
     antibodies-online proteins for KLHDC4 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLHDC4 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4