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Aliases for KLHDC3 Gene

Aliases for KLHDC3 Gene

  • Kelch Domain Containing 3 2 3
  • PEAS 3 4 6
  • Testis Intracellular Mediator Protein 3 4
  • Kelch Domain-Containing Protein 3 3
  • Protein Peas 4
  • DJ20C7.3 3

External Ids for KLHDC3 Gene

Previous GeneCards Identifiers for KLHDC3 Gene

  • GC06P042983
  • GC06P043030
  • GC06P043031
  • GC06P043089
  • GC06P042981
  • GC06P042699

Summaries for KLHDC3 Gene

Entrez Gene Summary for KLHDC3 Gene

  • The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012]

GeneCards Summary for KLHDC3 Gene

KLHDC3 (Kelch Domain Containing 3) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include chromatin binding. An important paralog of this gene is KLHDC1.

UniProtKB/Swiss-Prot for KLHDC3 Gene

  • May be involved in meiotic recombination process

Gene Wiki entry for KLHDC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC3 Gene

Genomics for KLHDC3 Gene

Regulatory Elements for KLHDC3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHDC3 Gene

43,014,103 bp from pter
43,021,298 bp from pter
7,196 bases
Plus strand

Genomic View for KLHDC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC3 Gene

Proteins for KLHDC3 Gene

  • Protein details for KLHDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K2W9

    Protein attributes for KLHDC3 Gene

    382 amino acids
    Molecular mass:
    43088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHDC3 Gene

Proteomics data for KLHDC3 Gene at MOPED

Post-translational modifications for KLHDC3 Gene

No Post-translational modifications

Other Protein References for KLHDC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KLHDC3 Gene

Domains for KLHDC3 Gene

Protein Domains for KLHDC3 Gene


Suggested Antigen Peptide Sequences for KLHDC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 Kelch repeats.
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KLHDC3: view

No data available for Gene Families for KLHDC3 Gene

Function for KLHDC3 Gene

Molecular function for KLHDC3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in meiotic recombination process

Gene Ontology (GO) - Molecular Function for KLHDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 12606021
GO:0005515 protein binding IPI 12482870
genes like me logo Genes that share ontologies with KLHDC3: view

Phenotypes for KLHDC3 Gene

GenomeRNAi human phenotypes for KLHDC3:
genes like me logo Genes that share phenotypes with KLHDC3: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHDC3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC3 Gene

Localization for KLHDC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC3 Gene

Cytoplasm. Note=Also found in meiotic chromatin. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for KLHDC3 Gene COMPARTMENTS Subcellular localization image for KLHDC3 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 12606021
GO:0005737 cytoplasm IDA 12606021
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KLHDC3: view

Pathways for KLHDC3 Gene

genes like me logo Genes that share pathways with KLHDC3: view

Gene Ontology (GO) - Biological Process for KLHDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0007131 reciprocal meiotic recombination NAS 12606021
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with KLHDC3: view

Transcripts for KLHDC3 Gene

Unigene Clusters for KLHDC3 Gene

Kelch domain containing 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHDC3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - - - - - - - - - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - -

Relevant External Links for KLHDC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHDC3 Gene

mRNA expression in normal human tissues for KLHDC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KLHDC3 Gene

This gene is overexpressed in Testis (37.1) and CD8 Tcells (31.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHDC3 Gene

SOURCE GeneReport for Unigene cluster for KLHDC3 Gene Hs.412468

genes like me logo Genes that share expressions with KLHDC3: view

Expression partners for KLHDC3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHDC3 Gene

Orthologs for KLHDC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KLHDC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHDC3 35
  • 93.63 (n)
  • 97.91 (a)
  • 61 (a)
(Canis familiaris)
Mammalia KLHDC3 35
  • 94.76 (n)
  • 97.91 (a)
  • 61 (a)
(Mus musculus)
Mammalia Klhdc3 35
  • 90.58 (n)
  • 96.6 (a)
Klhdc3 16
Klhdc3 36
  • 97 (a)
(Pan troglodytes)
Mammalia KLHDC3 35
  • 99.65 (n)
  • 99.74 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhdc3 35
  • 90.84 (n)
  • 97.12 (a)
(Monodelphis domestica)
Mammalia KLHDC3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia KLHDC3 36
  • 90 (a)
(Gallus gallus)
Aves KLHDC3 35
  • 77.57 (n)
  • 86.65 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia KLHDC3 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc3 35
  • 71.08 (n)
  • 76.72 (a)
Str.10302 35
African clawed frog
(Xenopus laevis)
Amphibia klhdc3-prov 35
(Danio rerio)
Actinopterygii Dr.16735 35
klhdc3 35
  • 72.74 (n)
  • 79.11 (a)
klhdc3 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009495 35
  • 50.97 (n)
  • 44.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12081 35
  • 54.84 (n)
  • 49.87 (a)
CG12081 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea F53E4.1 35
  • 51.1 (n)
  • 45.6 (a)
F53E4.1 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEL1 36
  • 6 (a)
KEL2 36
  • 9 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18610 35
  • 44.52 (n)
  • 31.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1216 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1927 36
  • 52 (a)
Species with no ortholog for KLHDC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHDC3 Gene

Gene Tree for KLHDC3 (if available)
Gene Tree for KLHDC3 (if available)

Paralogs for KLHDC3 Gene

Paralogs for KLHDC3 Gene

genes like me logo Genes that share paralogs with KLHDC3: view

Variants for KLHDC3 Gene

Sequence variations from dbSNP and Humsavar for KLHDC3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2295982 -- 43,017,099(+) AGCCT(C/T)GCCTG intron-variant
rs6904371 -- 43,018,625(+) TCTCT(C/T)CTTCC intron-variant
rs6926418 -- 43,018,235(+) TTTTT(C/T)TCCCA intron-variant
rs17854156 -- 43,018,686(+) TGAAC(C/T)GGCAC reference, missense, nc-transcript-variant
rs34597116 -- 43,018,891(+) GAACC(G/T)AAGGG reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHDC3 Gene

Variant ID Type Subtype PubMed ID
nsv462927 CNV Loss 19166990
nsv462930 CNV Loss 19166990
nsv885839 CNV Loss 21882294

Relevant External Links for KLHDC3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC3 Gene

Disorders for KLHDC3 Gene

No disorders were found for KLHDC3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KLHDC3 Gene

Publications for KLHDC3 Gene

  1. A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. (PMID: 12606021) Ohinata Y. … Mitsui Y. (FEBS Lett. 2003) 2 3 4 23
  2. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. (PMID: 12444059) Ohinata Y. … Mitsui Y. (Biol. Reprod. 2002) 2 3
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KLHDC3 Gene

Sources for KLHDC3 Gene

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