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Aliases for KLHDC3 Gene

Aliases for KLHDC3 Gene

  • Kelch Domain Containing 3 2 3 5
  • Testis Intracellular Mediator Protein 3 4
  • PEAS 3 4
  • Protein Peas 4
  • DJ20C7.3 3

External Ids for KLHDC3 Gene

Previous GeneCards Identifiers for KLHDC3 Gene

  • GC06P042983
  • GC06P043030
  • GC06P043031
  • GC06P043089
  • GC06P042981
  • GC06P042699

Summaries for KLHDC3 Gene

Entrez Gene Summary for KLHDC3 Gene

  • The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012]

GeneCards Summary for KLHDC3 Gene

KLHDC3 (Kelch Domain Containing 3) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Transport to the Golgi and subsequent modification. GO annotations related to this gene include chromatin binding. An important paralog of this gene is KLHDC1.

UniProtKB/Swiss-Prot for KLHDC3 Gene

  • May be involved in meiotic recombination process.

Gene Wiki entry for KLHDC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC3 Gene

Genomics for KLHDC3 Gene

Regulatory Elements for KLHDC3 Gene

Enhancers for KLHDC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHDC3 on UCSC Golden Path with GeneCards custom track

Promoters for KLHDC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHDC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHDC3 Gene

43,014,103 bp from pter
43,021,298 bp from pter
7,196 bases
Plus strand

Genomic View for KLHDC3 Gene

Genes around KLHDC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC3 Gene

Proteins for KLHDC3 Gene

  • Protein details for KLHDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K2W9

    Protein attributes for KLHDC3 Gene

    382 amino acids
    Molecular mass:
    43088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHDC3 Gene

Proteomics data for KLHDC3 Gene at MOPED

Post-translational modifications for KLHDC3 Gene

No Post-translational modifications

Other Protein References for KLHDC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC3 Gene

Domains & Families for KLHDC3 Gene

Protein Domains for KLHDC3 Gene


Suggested Antigen Peptide Sequences for KLHDC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 Kelch repeats.
  • Contains 5 Kelch repeats.
genes like me logo Genes that share domains with KLHDC3: view

No data available for Gene Families for KLHDC3 Gene

Function for KLHDC3 Gene

Molecular function for KLHDC3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in meiotic recombination process.
genes like me logo Genes that share phenotypes with KLHDC3: view

Animal Model Products

miRNA for KLHDC3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC3 Gene

Localization for KLHDC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC3 Gene

Cytoplasm. Note=Also found in meiotic chromatin. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for KLHDC3 Gene COMPARTMENTS Subcellular localization image for KLHDC3 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KLHDC3 Gene

Pathways & Interactions for KLHDC3 Gene

genes like me logo Genes that share pathways with KLHDC3: view

Gene Ontology (GO) - Biological Process for KLHDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007131 reciprocal meiotic recombination NAS 12606021
genes like me logo Genes that share ontologies with KLHDC3: view

No data available for SIGNOR curated interactions for KLHDC3 Gene

Drugs & Compounds for KLHDC3 Gene

No Compound Related Data Available

Transcripts for KLHDC3 Gene

Unigene Clusters for KLHDC3 Gene

Kelch domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - - - - - - - - - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - -

Relevant External Links for KLHDC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHDC3 Gene

mRNA expression in normal human tissues for KLHDC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHDC3 Gene

This gene is overexpressed in Testis (37.1) and CD8 Tcells (31.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHDC3 Gene

SOURCE GeneReport for Unigene cluster for KLHDC3 Gene Hs.412468

genes like me logo Genes that share expression patterns with KLHDC3: view

Protein tissue co-expression partners for KLHDC3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHDC3 Gene

Orthologs for KLHDC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KLHDC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHDC3 35
  • 93.63 (n)
  • 97.91 (a)
  • 61 (a)
(Canis familiaris)
Mammalia KLHDC3 35
  • 94.76 (n)
  • 97.91 (a)
  • 61 (a)
(Mus musculus)
Mammalia Klhdc3 35
  • 90.58 (n)
  • 96.6 (a)
Klhdc3 16
Klhdc3 36
  • 97 (a)
(Pan troglodytes)
Mammalia KLHDC3 35
  • 99.65 (n)
  • 99.74 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhdc3 35
  • 90.84 (n)
  • 97.12 (a)
(Monodelphis domestica)
Mammalia KLHDC3 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia KLHDC3 36
  • 90 (a)
(Gallus gallus)
Aves KLHDC3 35
  • 77.57 (n)
  • 86.65 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia KLHDC3 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc3 35
  • 71.08 (n)
  • 76.72 (a)
Str.10302 35
African clawed frog
(Xenopus laevis)
Amphibia klhdc3-prov 35
(Danio rerio)
Actinopterygii Dr.16735 35
klhdc3 35
  • 72.74 (n)
  • 79.11 (a)
klhdc3 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009495 35
  • 50.97 (n)
  • 44.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12081 35
  • 54.84 (n)
  • 49.87 (a)
CG12081 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea F53E4.1 35
  • 51.1 (n)
  • 45.6 (a)
F53E4.1 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEL1 36
  • 6 (a)
KEL2 36
  • 9 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18610 35
  • 44.52 (n)
  • 31.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1216 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1927 36
  • 52 (a)
Species with no ortholog for KLHDC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHDC3 Gene

Gene Tree for KLHDC3 (if available)
Gene Tree for KLHDC3 (if available)

Paralogs for KLHDC3 Gene

Paralogs for KLHDC3 Gene

genes like me logo Genes that share paralogs with KLHDC3: view

Variants for KLHDC3 Gene

Sequence variations from dbSNP and Humsavar for KLHDC3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs368631793 -- 43,019,405(+) GAGGG(C/T)GAGTG intron-variant
rs34650379 -- 43,019,334(+) TATAA(C/T)CTAGA nc-transcript-variant, reference, synonymous-codon
rs138663915 -- 43,019,267(+) TCCTT(C/T)CCACA intron-variant
rs537313696 -- 43,019,393(+) GAGGG(A/T)TTGAG intron-variant
rs371880247 -- 43,019,244(+) TCCTT(C/T)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHDC3 Gene

Variant ID Type Subtype PubMed ID
nsv462927 CNV Loss 19166990
nsv462930 CNV Loss 19166990
nsv885839 CNV Loss 21882294

Variation tolerance for KLHDC3 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLHDC3 Gene

Disorders for KLHDC3 Gene

Relevant External Links for KLHDC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHDC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC3 Gene

Publications for KLHDC3 Gene

  1. A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. (PMID: 12606021) Ohinata Y. … Mitsui Y. (FEBS Lett. 2003) 2 3 4 23 67
  2. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. (PMID: 12444059) Ohinata Y. … Mitsui Y. (Biol. Reprod. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PMID: 23455922) Varjosalo M. … Superti-Furga G. (Nat. Methods 2013) 3

Products for KLHDC3 Gene

Sources for KLHDC3 Gene