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KLHDC3 Gene

protein-coding   GIFtS: 54
GCID: GC06P042981

Kelch Domain Containing 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kelch Domain Containing 31 2
PEAS2 3 5
Testis Intracellular Mediator Protein2 3
dJ20C7.32
Kelch Domain-Containing Protein 32
Protein Peas3

External Ids:    HGNC: 207041   Entrez Gene: 1161382   Ensembl: ENSG000001247027   OMIM: 6112485   UniProtKB: Q9BQ903   

Export aliases for KLHDC3 gene to outside databases

Previous GC identifers: GC06P042983 GC06P043030 GC06P043031 GC06P043089 GC06P042699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLHDC3 Gene:
The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination
activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found
to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and
meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. (provided by RefSeq, Jun
2012)

GeneCards Summary for KLHDC3 Gene:
KLHDC3 (kelch domain containing 3) is a protein-coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is KLHDC2.

UniProtKB/Swiss-Prot: KLDC3_HUMAN, Q9BQ90
Function: May be involved in meiotic recombination process

Gene Wiki entry for KLHDC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLHDC3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   Roaz   C/EBPalpha   Egr-2   CHOP-10   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLHDC3 promoter sequence
   Search Chromatin IP Primers for KLHDC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLHDC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

KLHDC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLHDC3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P042981:  view genomic region     (about GC identifiers)

Start:
42,981,841 bp from pter      End:
42,989,036 bp from pter
Size:
7,196 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLDC3_HUMAN, Q9BQ90 (See protein sequence)
Recommended Name: Kelch domain-containing protein 3  
Size: 382 amino acids; 43088 Da
Secondary accessions: A8K2W9

Explore the universe of human proteins at neXtProt for KLHDC3: NX_Q9BQ90

Explore proteomics data for KLHDC3 at MOPED


See KLHDC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_476502.1  
ENSEMBL proteins: 
 ENSP00000313995   ENSP00000331562   ENSP00000244670  
Reactome Protein details: Q9BQ90

KLHDC3 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR011498 Kelch_2
 IPR015915 Kelch-typ_b-propeller

Graphical View of Domain Structure for InterPro Entry Q9BQ90

ProtoNet protein and cluster: Q9BQ90

1 Blocks protein domain: IPB011498 Kelch

UniProtKB/Swiss-Prot: KLDC3_HUMAN, Q9BQ90
Similarity: Contains 5 Kelch repeats


Find genes that share domains with KLHDC3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: KLDC3_HUMAN, Q9BQ90
Function: May be involved in meiotic recombination process

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003682chromatin binding IDA12606021
GO:0005515protein binding IPI12482870
     
Find genes that share ontologies with KLHDC3           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for KLHDC3:
 Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLHDC3
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLHDC3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLHDC3

miRNA
Products:
    
miRTarBase miRNAs that target KLHDC3:
hsa-mir-324-5p (MIRT043209), hsa-mir-20a-3p (MIRT038971), hsa-mir-93-3p (MIRT038784), hsa-mir-24-3p (MIRT030532), hsa-mir-149-5p (MIRT045462), hsa-mir-877-3p (MIRT036861)

Block miRNA regulation of human, mouse, rat KLHDC3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KLHDC3 (see all 23):
hsa-miR-4286 hsa-miR-513a-5p hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-181a-2* hsa-miR-340 hsa-miR-449a
SwitchGear 3'UTR luciferase reporter plasmidKLHDC3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat KLHDC3

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC3

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
KLDC3_HUMAN, Q9BQ90: Cytoplasm. Note=Also found in meiotic chromatin (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol4
mitochondrion1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000790nuclear chromatin IDA12606021
GO:0005737cytoplasm IDA12606021
GO:0005829cytosol TAS--

Find genes that share ontologies with KLHDC3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for KLHDC3 About    
See pathways by source

SuperPathContained pathways About
1Unfolded Protein Response
Unfolded Protein Response0.61
Activation of Chaperone Genes by XBP1(S)0.59
Activation of Chaperones by IRE1alpha0.61
2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins0.30


Find genes that share SuperPaths with KLHDC3           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for KLHDC3
    XBP1(S) activates chaperone genes


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLHDC3
Interactions:

    Search GeneGlobe Interaction Network for KLHDC3

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

Selected Interacting proteins for KLHDC3 (Q9BQ903 ENSP000003139954) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
InteractantInteraction Details
GeneCardExternal ID(s)
DLG3Q927963, ENSP000003634804I2D: score=2 STRING: ENSP00000363480
UBXN7O948883, ENSP000002963284I2D: score=2 STRING: ENSP00000296328
ADI1ENSP000003336664STRING: ENSP00000333666
CUL2ENSP000003638804STRING: ENSP00000363880
TCEB1ENSP000002848114STRING: ENSP00000284811
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
GO:0007131reciprocal meiotic recombination NAS12606021
GO:0030968endoplasmic reticulum unfolded protein response TAS--
GO:0044267cellular protein metabolic process TAS--

Find genes that share ontologies with KLHDC3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for KLHDC3 (KLDC3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for KLHDC3 gene (2 alternative transcripts): 
NM_057161.3  NM_001242872.1  

Unigene Cluster for KLHDC3:

Kelch domain containing 3
Hs.412468  [show with all ESTs]
Unigene Representative Sequence: NM_057161
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000326974(uc003otl.3 uc003otn.3 uc003otm.3 uc021yzr.1)
ENST00000332245(uc003oto.3) ENST00000244670
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat KLHDC3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate KLHDC3 (see all 23):
hsa-miR-4286 hsa-miR-513a-5p hsa-miR-202 hsa-miR-29c hsa-miR-29a hsa-miR-181a-2* hsa-miR-340 hsa-miR-449a
SwitchGear 3'UTR luciferase reporter plasmidKLHDC3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for KLHDC3
Predesigned siRNA for gene silencing in human, mouse, rat KLHDC3
Clone
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OriGene ORF clones in mouse, rat for KLHDC3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: KLHDC3 (NM_057161)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLHDC3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC3
Primer
Products:
    
OriGene qPCR primer pairs and template standards for KLHDC3
OriGene qSTAR qPCR primer pairs in human, mouse for KLHDC3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLHDC3
  QuantiTect SYBR Green Assays in human, mouse, rat KLHDC3
  QuantiFast Probe-based Assays in human, mouse, rat KLHDC3

Additional mRNA sequence: 

AB055925.1 AK097719.1 AK290384.1 BC000295.2 BC001789.1 BC001793.2 BC007296.1 BC021546.1 
BC041793.1 BC045612.1 NR_040101.1 

Selected DOTS entries (see all 31):

DT.100802149  DT.100892388  DT.455288  DT.87017301  DT.121385652  DT.100892383  DT.100892375  DT.121385680 
DT.121385719  DT.95331722  DT.100892356  DT.100892389  DT.121385672  DT.121385666  DT.92467136  DT.95340143 
DT.100045338  DT.40223712  DT.95339998  DT.100759070  DT.121385592  DT.121385620  DT.121385626  DT.121385653 

Selected AceView cDNA sequences (see all 971):

BQ889674 BF477690 BQ063579 CR620802 BC001793 CF264682 BQ059682 AA348636 
F07309 BQ063092 BF063121 AI050914 BX424626 BM766155 BM562610 BC001789 
CR598438 BE775102 BM672564 BG056962 CB153451 BP372210 AA378904 BU156243 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC3 (see all 10)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1:                                      -                                                                                                   
SP2:                                      -                                                                                                   
SP3:                                -     -                                                                                                   
SP4:                                      -     -                                                                                             
SP5:                    -     -           -                 -     -     -     -     -     -     -     -     -     -     -     -               


ECgene alternative splicing isoforms for KLHDC3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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KLHDC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGACCTCCTT
KLHDC3 Expression
About this image


KLHDC3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebral Cortex
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Placenta (Extraembryonic Tissues)
KLHDC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

KLHDC3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.412468
    Custom PCR Arrays for KLHDC3
Primer
Products:
OriGene qPCR primer pairs and template standards for KLHDC3
OriGene qSTAR qPCR primer pairs in human, mouse for KLHDC3
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QuantiTect SYBR Green Assays in human, mouse, rat KLHDC3
QuantiFast Probe-based Assays in human, mouse, rat KLHDC3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for KLHDC3 gene from Selected species (see all 19)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Klhdc31 , 5 kelch domain containing 31, 5 90.58(n)1
96.6(a)1
  17 (22.90 cM)5
717651  NM_001163729.21  NP_001157201.21 
 466745505 
chicken
(Gallus gallus)
Aves KLHDC31 kelch domain containing 3 77.57(n)
86.65(a)
  421251  XM_419323.4  XP_419323.3 
lizard
(Anolis carolinensis)
Reptilia KLHDC36
kelch domain containing 3
87(a)
1 ↔ 1
2(144726157-144758787)
African clawed frog
(Xenopus laevis)
Amphibia klhdc3-prov2 kelch domain containing 3 74.66(n)    BC056132.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.167352 Transcribed sequence with moderate similarity to protein more 77.89(n)    CK030046.1 
fruit fly
(Drosophila melanogaster)
Insecta CG120811 CG12081 54.84(n)
49.87(a)
  31799  NM_132266.2  NP_572494.1 
worm
(Caenorhabditis elegans)
Secernentea F53E4.11 F53E4.1 51.1(n)
45.6(a)
  180050  NM_001129476.3  NP_001122948.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEL26
KEL16
Protein that functions in a complex with Kel1p to ...
Protein required for proper cell fusion and cell m...
9(a)
6(a)
many ↔ many
many ↔ many
VII(966039-968687) YGR238C
VIII(413685-417179) YHR158C
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G186101 AT1G18610 44.52(n)
31.56(a)
  838442  NM_101719.6  NP_173296.3 


ENSEMBL Gene Tree for KLHDC3 (if available)
TreeFam Gene Tree for KLHDC3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for KLHDC3 gene
KLHDC22  HCFC12  KLHDC12  LZTR12  RABEPK2  KLHDC102  HCFC22  

Find genes that share paralogs with KLHDC3           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for KLHDC3 (see all 107)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1878021781,2
--42983780(+) GCAATA/TCTCCT 2 -- int10--------
rs1923782841,2
--42983792(+) CCTCAA/GCCTCC 2 -- int10--------
rs1847793031,2
--42984157(+) ACATAC/TCTTTC 2 -- int10--------
rs1435357861,2
--42984178(+) CCTGGC/TAGCAT 2 -- int10--------
rs1471279471,2
--42984209(+) GAACTC/GCTTGT 2 -- int10--------
rs1394883951,2
--42984291(+) CCAACC/TGCGGT 2 -- int10--------
rs1896108701,2
--42984294(+) ACCGCA/GGTAAC 2 -- int10--------
rs1918502321,2
--42984328(+) GTCCCA/GCCCTA 2 -- int10--------
rs1843273471,2
--42984525(+) CAAGAC/GAATAT 2 -- int10--------
rs1890503601,2
--42984532(+) ATATAC/TCGTTT 2 -- int10--------

HapMap Linkage Disequilibrium report for KLHDC3 (42981841 - 42989036 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for KLHDC3:    About this table    
Variant IDTypeSubtypePubMed ID
nsv462930CNV Loss19166990
nsv885839CNV Loss21882294
nsv462927CNV Loss19166990

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611248    OMIM disorders: --


Find genes that share disorders with KLHDC3           About GenesLikeMe


Export disorders for KLHDC3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for KLHDC3 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with KLHDC3)
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  1. A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. (PubMed id 12606021)1, 2, 3, 9 Ohinata Y.... Mitsui Y. (FEBS Lett. 2003)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  5. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. (PubMed id 12444059)1, 3 Ohinata Y....Mitsui Y. (Biol. Reprod. 2002)
  6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
  7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  9. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
  10. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. (PubMed id 18775313)1 Alexandru G....Deshaies R.J. (Cell 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 116138 HGNC: 20704 AceView: PPP2R5D Ensembl:ENSG00000124702 euGenes: HUgn116138
ECgene: KLHDC3 H-InvDB: KLHDC3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for KLHDC3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for KLHDC3 gene:
Search GeneIP for patents involving KLHDC3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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