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Aliases for KLHDC3 Gene

Aliases for KLHDC3 Gene

  • Kelch Domain Containing 3 2 3
  • PEAS 3 4 6
  • Testis Intracellular Mediator Protein 3 4
  • Kelch Domain-Containing Protein 3 3
  • Protein Peas 4
  • DJ20C7.3 3

External Ids for KLHDC3 Gene

Summaries for KLHDC3 Gene

Entrez Gene Summary for KLHDC3 Gene

  • The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specifically in testis. Its expression in pachytene spermatocytes is localized to cytoplasma and meiotic chromatin, suggesting that this gene may be involved in meiotic recombination. [provided by RefSeq, Jun 2012]

GeneCards Summary for KLHDC3 Gene

KLHDC3 (Kelch Domain Containing 3) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. GO annotations related to this gene include chromatin binding. An important paralog of this gene is KLHDC1.

UniProtKB/Swiss-Prot for KLHDC3 Gene

  • May be involved in meiotic recombination process

Gene Wiki entry for KLHDC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC3 Gene

Genomics for KLHDC3 Gene

Genomic Location for KLHDC3 Gene

Start:
43,014,103 bp from pter
End:
43,021,298 bp from pter
Size:
7,196 bases
Orientation:
Plus strand

Genomic View for KLHDC3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHDC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC3 Gene

Regulatory Elements for KLHDC3 Gene

Proteins for KLHDC3 Gene

  • Protein details for KLHDC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ90-KLDC3_HUMAN
    Recommended name:
    Kelch domain-containing protein 3
    Protein Accession:
    Q9BQ90
    Secondary Accessions:
    • A8K2W9

    Protein attributes for KLHDC3 Gene

    Size:
    382 amino acids
    Molecular mass:
    43088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLHDC3 Gene

Proteomics data for KLHDC3 Gene at MOPED

Post-translational modifications for KLHDC3 Gene

No Post-translational modifications

Other Protein References for KLHDC3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC3 Gene

Domains for KLHDC3 Gene

Protein Domains for KLHDC3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

KLDC3_HUMAN
Similarity:
  • Contains 5 Kelch repeats.:
    • Q9BQ90
genes like me logo Genes that share domains with KLHDC3: view

No data available for Gene Families for KLHDC3 Gene

Function for KLHDC3 Gene

Molecular function for KLHDC3 Gene

UniProtKB/Swiss-Prot Function: May be involved in meiotic recombination process

Gene Ontology (GO) - Molecular Function for KLHDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 12606021
GO:0005515 protein binding IPI 12482870
genes like me logo Genes that share ontologies with KLHDC3: view

Phenotypes for KLHDC3 Gene

GenomeRNAi human phenotypes for KLHDC3:
genes like me logo Genes that share phenotypes with KLHDC3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHDC3 Gene

Localization for KLHDC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC3 Gene

Cytoplasm. Note=Also found in meiotic chromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHDC3 Gene COMPARTMENTS Subcellular localization image for KLHDC3 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 12606021
GO:0005737 cytoplasm IDA 12606021
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KLHDC3: view

Pathways for KLHDC3 Gene

genes like me logo Genes that share pathways with KLHDC3: view

Gene Ontology (GO) - Biological Process for KLHDC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0007131 reciprocal meiotic recombination NAS 12606021
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with KLHDC3: view

Transcripts for KLHDC3 Gene

Unigene Clusters for KLHDC3 Gene

Kelch domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - - - - - - - - - - - - - -
SP6: - - -
SP7: - - - - -
SP8: - - -
SP9:
SP10:

Relevant External Links for KLHDC3 Gene

GeneLoc Exon Structure for
KLHDC3
ECgene alternative splicing isoforms for
KLHDC3

Expression for KLHDC3 Gene

mRNA expression in normal human tissues for KLHDC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHDC3 Gene

SOURCE GeneReport for Unigene cluster for KLHDC3 Gene Hs.412468

genes like me logo Genes that share expressions with KLHDC3: view

Orthologs for KLHDC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KLHDC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHDC3 36
  • 99.65 (n)
  • 99.74 (a)
KLHDC3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHDC3 36
  • 93.63 (n)
  • 97.91 (a)
KLHDC3 37
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHDC3 36
  • 94.76 (n)
  • 97.91 (a)
KLHDC3 37
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhdc3 36
  • 90.58 (n)
  • 96.6 (a)
Klhdc3 16
Klhdc3 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHDC3 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHDC3 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhdc3 36
  • 90.84 (n)
  • 97.12 (a)
chicken
(Gallus gallus)
Aves KLHDC3 36
  • 77.57 (n)
  • 86.65 (a)
KLHDC3 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHDC3 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia klhdc3-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc3 36
  • 71.08 (n)
  • 76.72 (a)
Str.10302 36
zebrafish
(Danio rerio)
Actinopterygii Dr.16735 36
klhdc3 36
  • 72.74 (n)
  • 79.11 (a)
klhdc3 37
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009495 36
  • 50.97 (n)
  • 44.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12081 36
  • 54.84 (n)
  • 49.87 (a)
CG12081 37
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F53E4.1 36
  • 51.1 (n)
  • 45.6 (a)
F53E4.1 37
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEL1 37
  • 6 (a)
ManyToMany
KEL2 37
  • 9 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G18610 36
  • 44.52 (n)
  • 31.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1216 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1927 37
  • 52 (a)
OneToOne
Species with no ortholog for KLHDC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHDC3 Gene

ENSEMBL:
Gene Tree for KLHDC3 (if available)
TreeFam:
Gene Tree for KLHDC3 (if available)

Paralogs for KLHDC3 Gene

Paralogs for KLHDC3 Gene

genes like me logo Genes that share paralogs with KLHDC3: view

Variants for KLHDC3 Gene

Sequence variations from dbSNP and Humsavar for KLHDC3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2295982 -- 43,017,099(+) AGCCT(C/T)GCCTG intron-variant
rs6904371 -- 43,018,625(+) TCTCT(C/T)CTTCC intron-variant
rs6926418 -- 43,018,235(+) TTTTT(C/T)TCCCA intron-variant
rs17854156 -- 43,018,686(+) TGAAC(C/T)GGCAC reference, missense, nc-transcript-variant
rs34597116 -- 43,018,891(+) GAACC(G/T)AAGGG reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for KLHDC3 Gene

Variant ID Type Subtype PubMed ID
nsv462927 CNV Loss 19166990
nsv462930 CNV Loss 19166990
nsv885839 CNV Loss 21882294

Relevant External Links for KLHDC3 Gene

HapMap Linkage Disequilibrium report
KLHDC3

Disorders for KLHDC3 Gene

No disorders were found for KLHDC3 Gene.

No data available for UniProtKB/Swiss-Prot for KLHDC3 Gene

Publications for KLHDC3 Gene

  1. A novel testis-specific RAG2-like protein, Peas: its expression in pachytene spermatocyte cytoplasm and meiotic chromatin. (PMID: 12606021) Ohinata Y. … Mitsui Y. (FEBS Lett. 2003) 2 3 4 23
  2. Male-enhanced antigen-1 gene flanked by two overlapping genes is expressed in late spermatogenesis. (PMID: 12444059) Ohinata Y. … Mitsui Y. (Biol. Reprod. 2002) 2 3
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KLHDC3 Gene

Sources for KLHDC3 Gene

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