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Aliases for KLHDC2 Gene

Aliases for KLHDC2 Gene

  • Kelch Domain Containing 2 2 3
  • Hepatocellular Carcinoma-Associated Antigen 33 3 4
  • Host Cell Factor-Like Protein 1 3 4
  • Host Cell Factor Homolog LCP 3 4
  • HCLP-1 3 4
  • HCLP1 3 6
  • Kelch Domain-Containing Protein 2 3
  • HCA33 4
  • LCP 3

External Ids for KLHDC2 Gene

Previous GeneCards Identifiers for KLHDC2 Gene

  • GC14P044030
  • GC14P048224
  • GC14P049304
  • GC14P050234
  • GC14P030362

Summaries for KLHDC2 Gene

GeneCards Summary for KLHDC2 Gene

KLHDC2 (Kelch Domain Containing 2) is a Protein Coding gene. Diseases associated with KLHDC2 include hepatocellular carcinoma. An important paralog of this gene is KLHDC1.

UniProtKB/Swiss-Prot for KLHDC2 Gene

  • Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC2 Gene

Genomics for KLHDC2 Gene

Regulatory Elements for KLHDC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHDC2 Gene

49,767,589 bp from pter
49,786,385 bp from pter
18,797 bases
Plus strand

Genomic View for KLHDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC2 Gene

Proteins for KLHDC2 Gene

  • Protein details for KLHDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B3KPF9
    • Q6IAF0
    • Q86TY9

    Protein attributes for KLHDC2 Gene

    406 amino acids
    Molecular mass:
    46099 Da
    Quaternary structure:
    • Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA and herpes simplex virus transactivator VP16.

    Alternative splice isoforms for KLHDC2 Gene


neXtProt entry for KLHDC2 Gene

Proteomics data for KLHDC2 Gene at MOPED

Post-translational modifications for KLHDC2 Gene

  • Ubiquitination at Lys51 and Lys117
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHDC2 Gene

Antibody Products

No data available for DME Specific Peptides for KLHDC2 Gene

Domains for KLHDC2 Gene

Protein Domains for KLHDC2 Gene


Suggested Antigen Peptide Sequences for KLHDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 Kelch repeats.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHDC2: view

No data available for Gene Families for KLHDC2 Gene

Function for KLHDC2 Gene

Molecular function for KLHDC2 Gene

UniProtKB/Swiss-Prot Function:
Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.

Gene Ontology (GO) - Molecular Function for KLHDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHDC2: view
genes like me logo Genes that share phenotypes with KLHDC2: view

Animal Model Products

miRNA for KLHDC2 Gene

miRTarBase miRNAs that target KLHDC2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHDC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC2 Gene

Localization for KLHDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC2 Gene

Subcellular locations from

Jensen Localization Image for KLHDC2 Gene COMPARTMENTS Subcellular localization image for KLHDC2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KLHDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLHDC2: view

Pathways for KLHDC2 Gene

SuperPathways for KLHDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC2 Gene


No data available for Pathways by source for KLHDC2 Gene

Transcripts for KLHDC2 Gene

Unigene Clusters for KLHDC2 Gene

Kelch domain containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHDC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2: - - -
SP3: -
SP6: -

Relevant External Links for KLHDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHDC2 Gene

mRNA expression in normal human tissues for KLHDC2 Gene

Protein differential expression in normal tissues for KLHDC2 Gene

This gene is overexpressed in Adrenal (47.7) and Placenta (21.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHDC2 Gene

SOURCE GeneReport for Unigene cluster for KLHDC2 Gene Hs.509264

mRNA Expression by UniProt/SwissProt for KLHDC2 Gene

Tissue specificity: Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes.
genes like me logo Genes that share expressions with KLHDC2: view

Expression partners for KLHDC2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KLHDC2 Gene

Orthologs for KLHDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLHDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHDC2 35
  • 94.09 (n)
  • 96.8 (a)
  • 97 (a)
(Canis familiaris)
Mammalia KLHDC2 35
  • 95.81 (n)
  • 98.77 (a)
  • 99 (a)
(Mus musculus)
Mammalia Klhdc2 35
  • 91.46 (n)
  • 96.8 (a)
Klhdc2 16
Klhdc2 36
  • 97 (a)
(Pan troglodytes)
Mammalia KLHDC2 35
  • 99.75 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhdc2 35
  • 91.79 (n)
  • 97.04 (a)
(Monodelphis domestica)
Mammalia KLHDC2 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia KLHDC2 36
  • 89 (a)
(Gallus gallus)
Aves KLHDC2 35
  • 79.06 (n)
  • 84.98 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia KLHDC2 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc2 35
  • 69.82 (n)
  • 64.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19210 35
(Danio rerio)
Actinopterygii Dr.15588 35
zgc:162310 35
  • 59.49 (n)
  • 55.7 (a)
  • 50 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEL1 36
  • 8 (a)
KEL2 36
  • 10 (a)
Species with no ortholog for KLHDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHDC2 Gene

Gene Tree for KLHDC2 (if available)
Gene Tree for KLHDC2 (if available)

Paralogs for KLHDC2 Gene

Paralogs for KLHDC2 Gene

(1) SIMAP similar genes for KLHDC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KLHDC2: view

Variants for KLHDC2 Gene

Sequence variations from dbSNP and Humsavar for KLHDC2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1128454 -- 49,779,771(+) CTTCA(A/C)TATCT missense, reference
rs4243563 -- 49,770,050(+) TCAAT(C/G)ACACT intron-variant
rs4284545 -- 49,770,623(+) CTCCA(C/T)CATTA intron-variant
rs4354830 -- 49,771,853(+) TAGCC(A/G)GGCAT intron-variant
rs4391967 -- 49,767,859(+) CAATC(C/T)GGCTA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHDC2 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545
nsv1269 CNV Insertion 18451855
nsv509533 CNV Insertion 20534489
nsv901937 CNV Loss 21882294

Relevant External Links for KLHDC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC2 Gene

Disorders for KLHDC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for KLHDC2 Gene in MalaCards »

(1) Disease for KLHDC2 Gene

Relevant External Links for KLHDC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KLHDC2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KLHDC2 Gene

Publications for KLHDC2 Gene

  1. Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2. (PMID: 16964437) Chin K.-T. … Jin D.-Y. (Mol. Cell. Biochem. 2007) 3 4 23
  2. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. (PMID: 11384994) Zhou H.-J. … Jin D.-Y. (J. Biol. Chem. 2001) 2 3 4
  3. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KLHDC2 Gene

Sources for KLHDC2 Gene

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