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Aliases for KLHDC2 Gene

Aliases for KLHDC2 Gene

  • Kelch Domain Containing 2 2 3
  • Hepatocellular Carcinoma-Associated Antigen 33 3 4
  • Host Cell Factor-Like Protein 1 3 4
  • Host Cell Factor Homolog LCP 3 4
  • HCLP-1 3 4
  • HCLP1 3 6
  • Kelch Domain-Containing Protein 2 3
  • HCA33 4
  • LCP 3

External Ids for KLHDC2 Gene

Previous GeneCards Identifiers for KLHDC2 Gene

  • GC14P044030
  • GC14P048224
  • GC14P049304
  • GC14P050234
  • GC14P030362

Summaries for KLHDC2 Gene

GeneCards Summary for KLHDC2 Gene

KLHDC2 (Kelch Domain Containing 2) is a Protein Coding gene. Diseases associated with KLHDC2 include hepatocellular carcinoma. An important paralog of this gene is KLHDC1.

UniProtKB/Swiss-Prot for KLHDC2 Gene

  • Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC2 Gene

Genomics for KLHDC2 Gene

Regulatory Elements for KLHDC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHDC2 Gene

Start:
49,767,589 bp from pter
End:
49,786,385 bp from pter
Size:
18,797 bases
Orientation:
Plus strand

Genomic View for KLHDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC2 Gene

Proteins for KLHDC2 Gene

  • Protein details for KLHDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2U9-KLDC2_HUMAN
    Recommended name:
    Kelch domain-containing protein 2
    Protein Accession:
    Q9Y2U9
    Secondary Accessions:
    • B3KPF9
    • Q6IAF0
    • Q86TY9

    Protein attributes for KLHDC2 Gene

    Size:
    406 amino acids
    Molecular mass:
    46099 Da
    Quaternary structure:
    • Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA and herpes simplex virus transactivator VP16.

    Alternative splice isoforms for KLHDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLHDC2 Gene

Proteomics data for KLHDC2 Gene at MOPED

Post-translational modifications for KLHDC2 Gene

  • Ubiquitination at Lys51 and Lys117
  • Modification sites at PhosphoSitePlus

Other Protein References for KLHDC2 Gene

No data available for DME Specific Peptides for KLHDC2 Gene

Domains for KLHDC2 Gene

Protein Domains for KLHDC2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for KLHDC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y2U9

UniProtKB/Swiss-Prot:

KLDC2_HUMAN :
  • Q9Y2U9
Similarity:
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHDC2: view

No data available for Gene Families for KLHDC2 Gene

Function for KLHDC2 Gene

Molecular function for KLHDC2 Gene

UniProtKB/Swiss-Prot Function: Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.

Gene Ontology (GO) - Molecular Function for KLHDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KLHDC2: view
genes like me logo Genes that share phenotypes with KLHDC2: view

Animal Model Products

CRISPR Products

miRNA for KLHDC2 Gene

miRTarBase miRNAs that target KLHDC2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHDC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLHDC2 Gene

Localization for KLHDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLHDC2 Gene COMPARTMENTS Subcellular localization image for KLHDC2 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KLHDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLHDC2: view

Pathways for KLHDC2 Gene

SuperPathways for KLHDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC2 Gene

None

No data available for Pathways by source for KLHDC2 Gene

Transcripts for KLHDC2 Gene

Unigene Clusters for KLHDC2 Gene

Kelch domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLHDC2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6: -

Relevant External Links for KLHDC2 Gene

GeneLoc Exon Structure for
KLHDC2
ECgene alternative splicing isoforms for
KLHDC2

Expression for KLHDC2 Gene

mRNA expression in normal human tissues for KLHDC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHDC2 Gene

SOURCE GeneReport for Unigene cluster for KLHDC2 Gene Hs.509264

mRNA Expression by UniProt/SwissProt for KLHDC2 Gene

Q9Y2U9-KLDC2_HUMAN
Tissue specificity: Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes.
genes like me logo Genes that share expressions with KLHDC2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KLHDC2 Gene

Orthologs for KLHDC2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLHDC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLHDC2 35
  • 99.75 (n)
  • 100 (a)
KLHDC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLHDC2 35
  • 94.09 (n)
  • 96.8 (a)
KLHDC2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLHDC2 35
  • 95.81 (n)
  • 98.77 (a)
KLHDC2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klhdc2 35
  • 91.46 (n)
  • 96.8 (a)
Klhdc2 16
Klhdc2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLHDC2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLHDC2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klhdc2 35
  • 91.79 (n)
  • 97.04 (a)
chicken
(Gallus gallus)
Aves KLHDC2 35
  • 79.06 (n)
  • 84.98 (a)
KLHDC2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLHDC2 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19210 35
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc2 35
  • 69.82 (n)
  • 64.19 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.15588 35
KLHDC2 36
  • 50 (a)
OneToOne
zgc:162310 35
  • 59.49 (n)
  • 55.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KEL1 36
  • 8 (a)
ManyToMany
KEL2 36
  • 10 (a)
ManyToMany
Species with no ortholog for KLHDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLHDC2 Gene

ENSEMBL:
Gene Tree for KLHDC2 (if available)
TreeFam:
Gene Tree for KLHDC2 (if available)

Paralogs for KLHDC2 Gene

Paralogs for KLHDC2 Gene

Selected SIMAP similar genes for KLHDC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KLHDC2: view

Variants for KLHDC2 Gene

Sequence variations from dbSNP and Humsavar for KLHDC2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1128454 -- 49,779,771(+) CTTCA(A/C)TATCT missense, reference
rs4243563 -- 49,770,050(+) TCAAT(C/G)ACACT intron-variant
rs4284545 -- 49,770,623(+) CTCCA(C/T)CATTA intron-variant
rs4354830 -- 49,771,853(+) TAGCC(A/G)GGCAT intron-variant
rs4391967 -- 49,767,859(+) CAATC(C/T)GGCTA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHDC2 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545
nsv1269 CNV Insertion 18451855
nsv509533 CNV Insertion 20534489
nsv901937 CNV Loss 21882294

Relevant External Links for KLHDC2 Gene

HapMap Linkage Disequilibrium report
KLHDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC2 Gene

Disorders for KLHDC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KLHDC2 Gene including...

Search for KLHDC2 Gene in MalaCards »

Relevant External Links for KLHDC2

Genetic Association Database (GAD)
KLHDC2
Human Genome Epidemiology (HuGE) Navigator
KLHDC2
genes like me logo Genes that share disorders with KLHDC2: view

No data available for UniProtKB/Swiss-Prot for KLHDC2 Gene

Publications for KLHDC2 Gene

  1. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. (PMID: 11384994) Zhou H.-J. … Jin D.-Y. (J. Biol. Chem. 2001) 2 3 4
  2. Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2. (PMID: 16964437) Chin K.-T. … Jin D.-Y. (Mol. Cell. Biochem. 2007) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 3 4

Products for KLHDC2 Gene

Sources for KLHDC2 Gene

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