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Aliases for KLHDC10 Gene

Aliases for KLHDC10 Gene

  • Kelch Domain Containing 10 2 3
  • Slim 3 6
  • Scruin Like At The Midline Homolog (Drosophila) 2
  • Kelch Domain-Containing Protein 10 3
  • Scruin Like At The Midline Homolog 3
  • PNAS-119 3
  • KIAA0265 4

External Ids for KLHDC10 Gene

Previous GeneCards Identifiers for KLHDC10 Gene

  • GC07P129498
  • GC07P129710
  • GC07P124072

Summaries for KLHDC10 Gene

GeneCards Summary for KLHDC10 Gene

KLHDC10 (Kelch Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is KLHDC1.

UniProtKB/Swiss-Prot for KLHDC10 Gene

  • Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC10 Gene

Genomics for KLHDC10 Gene

Regulatory Elements for KLHDC10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLHDC10 Gene

130,070,509 bp from pter
130,135,720 bp from pter
65,212 bases
Plus strand

Genomic View for KLHDC10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLHDC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC10 Gene

Proteins for KLHDC10 Gene

  • Protein details for KLHDC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • Q86Y99
    • Q92554

    Protein attributes for KLHDC10 Gene

    442 amino acids
    Molecular mass:
    49098 Da
    Quaternary structure:
    • Interacts with CUL2, TCEB1 and TCEB2; may be the substrate recognition component of an E3 ubiquitin ligase complex. Interacts (via the 6 Kelch repeats) with PPP5C.
    • Sequence=BAA13395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHDC10 Gene


neXtProt entry for KLHDC10 Gene

Proteomics data for KLHDC10 Gene at MOPED

Post-translational modifications for KLHDC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHDC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC10 Gene

Domains for KLHDC10 Gene

Protein Domains for KLHDC10 Gene


Suggested Antigen Peptide Sequences for KLHDC10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 Kelch repeats.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHDC10: view

No data available for Gene Families for KLHDC10 Gene

Function for KLHDC10 Gene

Molecular function for KLHDC10 Gene

UniProtKB/Swiss-Prot Function:
Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.

Gene Ontology (GO) - Molecular Function for KLHDC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
genes like me logo Genes that share ontologies with KLHDC10: view

Animal Model Products

CRISPR Products

miRNA for KLHDC10 Gene

miRTarBase miRNAs that target KLHDC10

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC10 Gene

Localization for KLHDC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC10 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for KLHDC10 Gene COMPARTMENTS Subcellular localization image for KLHDC10 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KLHDC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KLHDC10: view

Pathways for KLHDC10 Gene

SuperPathways for KLHDC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC10 Gene


No data available for Pathways by source for KLHDC10 Gene

Transcripts for KLHDC10 Gene

Unigene Clusters for KLHDC10 Gene

Kelch domain containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP3: - -

Relevant External Links for KLHDC10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHDC10 Gene

mRNA expression in normal human tissues for KLHDC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KLHDC10 Gene

This gene is overexpressed in Pancreatic juice (23.4), Heart (21.2), and Platelet (20.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHDC10 Gene

SOURCE GeneReport for Unigene cluster for KLHDC10 Gene Hs.520710

genes like me logo Genes that share expressions with KLHDC10: view

Expression partners for KLHDC10 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHDC10 Gene

Orthologs for KLHDC10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHDC10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHDC10 35
  • 95.78 (n)
  • 99.55 (a)
KLHDC10 36
  • 100 (a)
(Canis familiaris)
Mammalia KLHDC10 35
  • 96.32 (n)
  • 99.49 (a)
KLHDC10 36
  • 99 (a)
(Mus musculus)
Mammalia Klhdc10 35
  • 90.81 (n)
  • 97.04 (a)
Klhdc10 16
Klhdc10 36
  • 97 (a)
(Pan troglodytes)
Mammalia KLHDC10 35
  • 99.85 (n)
  • 100 (a)
KLHDC10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhdc10 35
  • 89.51 (n)
  • 96.83 (a)
(Monodelphis domestica)
Mammalia KLHDC10 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia KLHDC10 36
  • 91 (a)
(Gallus gallus)
Aves KLHDC10 35
  • 80.46 (n)
  • 89.2 (a)
KLHDC10 36
  • 83 (a)
(Anolis carolinensis)
Reptilia KLHDC10 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc10 35
  • 75.92 (n)
  • 83.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21326 35
(Danio rerio)
Actinopterygii klhdc10 35
  • 75.82 (n)
  • 85.07 (a)
zgc55663 35
klhdc10 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005004 35
  • 48.26 (n)
  • 42.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta slim 35
  • 48.59 (n)
  • 42.78 (a)
slim 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y67H2A.2 35
  • 45.3 (n)
  • 34.67 (a)
Y67H2A.2 36
  • 18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2435 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8396 36
  • 44 (a)
Species with no ortholog for KLHDC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHDC10 Gene

Gene Tree for KLHDC10 (if available)
Gene Tree for KLHDC10 (if available)

Paralogs for KLHDC10 Gene

Paralogs for KLHDC10 Gene

genes like me logo Genes that share paralogs with KLHDC10: view

Variants for KLHDC10 Gene

Sequence variations from dbSNP and Humsavar for KLHDC10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6821 -- 130,134,874(+) AACTC(C/T)AGACG utr-variant-3-prime
rs1062154 -- 130,070,684(+) GAGGG(C/G)AGGAG missense, reference
rs1137778 -- 130,133,585(+) TCCAA(C/T)TCTTA utr-variant-3-prime
rs1138035 -- 130,135,567(+) TTTCC(A/C)CTTTA utr-variant-3-prime
rs1138040 -- 130,135,669(+) GTTTT(C/T)TAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLHDC10 Gene

Variant ID Type Subtype PubMed ID
nsv510968 CNV Complex 20534489
nsv366394 CNV Loss 16902084

Relevant External Links for KLHDC10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLHDC10 Gene

Disorders for KLHDC10 Gene

Relevant External Links for KLHDC10

Genetic Association Database (GAD)

No disorders were found for KLHDC10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KLHDC10 Gene

Publications for KLHDC10 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  2. The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. (PMID: 23102700) Sekine Y. … Ichijo H. (Mol. Cell 2012) 3 4
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for KLHDC10 Gene

Sources for KLHDC10 Gene

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