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Aliases for KLHDC10 Gene

Aliases for KLHDC10 Gene

  • Kelch Domain Containing 10 2 3 5
  • Scruin Like At The Midline Homolog (Drosophila) 2
  • Scruin Like At The Midline Homolog 3
  • PNAS-119 3
  • KIAA0265 4
  • SLIM 3

External Ids for KLHDC10 Gene

Previous GeneCards Identifiers for KLHDC10 Gene

  • GC07P129498
  • GC07P129710
  • GC07P124072

Summaries for KLHDC10 Gene

GeneCards Summary for KLHDC10 Gene

KLHDC10 (Kelch Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is KLHDC1.

UniProtKB/Swiss-Prot for KLHDC10 Gene

  • Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLHDC10 Gene

Genomics for KLHDC10 Gene

Regulatory Elements for KLHDC10 Gene

Enhancers for KLHDC10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLHDC10 on UCSC Golden Path with GeneCards custom track

Promoters for KLHDC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLHDC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLHDC10 Gene

130,070,509 bp from pter
130,135,720 bp from pter
65,212 bases
Plus strand

Genomic View for KLHDC10 Gene

Genes around KLHDC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLHDC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLHDC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLHDC10 Gene

Proteins for KLHDC10 Gene

  • Protein details for KLHDC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kelch domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • Q86Y99
    • Q92554

    Protein attributes for KLHDC10 Gene

    442 amino acids
    Molecular mass:
    49098 Da
    Quaternary structure:
    • Interacts with CUL2, TCEB1 and TCEB2; may be the substrate recognition component of an E3 ubiquitin ligase complex. Interacts (via the 6 Kelch repeats) with PPP5C.
    • Sequence=BAA13395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLHDC10 Gene


neXtProt entry for KLHDC10 Gene

Proteomics data for KLHDC10 Gene at MOPED

Post-translational modifications for KLHDC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLHDC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLHDC10 Gene

Domains & Families for KLHDC10 Gene

Protein Domains for KLHDC10 Gene


Suggested Antigen Peptide Sequences for KLHDC10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 Kelch repeats.
  • Contains 6 Kelch repeats.
genes like me logo Genes that share domains with KLHDC10: view

No data available for Gene Families for KLHDC10 Gene

Function for KLHDC10 Gene

Molecular function for KLHDC10 Gene

UniProtKB/Swiss-Prot Function:
Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.
genes like me logo Genes that share phenotypes with KLHDC10: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLHDC10 Gene

Localization for KLHDC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLHDC10 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for KLHDC10 Gene COMPARTMENTS Subcellular localization image for KLHDC10 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for KLHDC10 Gene

Pathways & Interactions for KLHDC10 Gene

SuperPathways for KLHDC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLHDC10 Gene


No data available for Pathways by source and SIGNOR curated interactions for KLHDC10 Gene

Drugs & Compounds for KLHDC10 Gene

No Compound Related Data Available

Transcripts for KLHDC10 Gene

Unigene Clusters for KLHDC10 Gene

Kelch domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP3: - -

Relevant External Links for KLHDC10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLHDC10 Gene

mRNA expression in normal human tissues for KLHDC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLHDC10 Gene

This gene is overexpressed in Pancreatic juice (23.4), Heart (21.2), and Platelet (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLHDC10 Gene

SOURCE GeneReport for Unigene cluster for KLHDC10 Gene Hs.520710

genes like me logo Genes that share expression patterns with KLHDC10: view

Protein tissue co-expression partners for KLHDC10 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLHDC10 Gene

Orthologs for KLHDC10 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLHDC10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KLHDC10 35
  • 95.78 (n)
  • 99.55 (a)
KLHDC10 36
  • 100 (a)
(Canis familiaris)
Mammalia KLHDC10 35
  • 96.32 (n)
  • 99.49 (a)
KLHDC10 36
  • 99 (a)
(Mus musculus)
Mammalia Klhdc10 35
  • 90.81 (n)
  • 97.04 (a)
Klhdc10 16
Klhdc10 36
  • 97 (a)
(Pan troglodytes)
Mammalia KLHDC10 35
  • 99.85 (n)
  • 100 (a)
KLHDC10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Klhdc10 35
  • 89.51 (n)
  • 96.83 (a)
(Monodelphis domestica)
Mammalia KLHDC10 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia KLHDC10 36
  • 91 (a)
(Gallus gallus)
Aves KLHDC10 35
  • 80.46 (n)
  • 89.2 (a)
KLHDC10 36
  • 83 (a)
(Anolis carolinensis)
Reptilia KLHDC10 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia klhdc10 35
  • 75.92 (n)
  • 83.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21326 35
(Danio rerio)
Actinopterygii klhdc10 35
  • 75.82 (n)
  • 85.07 (a)
zgc55663 35
klhdc10 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005004 35
  • 48.26 (n)
  • 42.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta slim 35
  • 48.59 (n)
  • 42.78 (a)
slim 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y67H2A.2 35
  • 45.3 (n)
  • 34.67 (a)
Y67H2A.2 36
  • 18 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2435 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8396 36
  • 44 (a)
Species with no ortholog for KLHDC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLHDC10 Gene

Gene Tree for KLHDC10 (if available)
Gene Tree for KLHDC10 (if available)

Paralogs for KLHDC10 Gene

Paralogs for KLHDC10 Gene

genes like me logo Genes that share paralogs with KLHDC10: view

Variants for KLHDC10 Gene

Sequence variations from dbSNP and Humsavar for KLHDC10 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3734928 - 130,070,648(+) CATGT(C/T)GGCCG reference, missense
rs17854337 - 130,120,821(+) CAATG(A/G)CGTCC reference, missense
rs17854336 - 130,124,491(+) TTTAC(A/G)TCTTG reference, missense
rs17857292 - 130,125,884(+) CCTTG(A/G)AACGA reference, missense
rs10241894 - 130,130,726(+) AGGGA(A/C)TCATC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KLHDC10 Gene

Variant ID Type Subtype PubMed ID
nsv510968 CNV Complex 20534489
nsv366394 CNV Loss 16902084

Variation tolerance for KLHDC10 Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KLHDC10 Gene

Disorders for KLHDC10 Gene

Relevant External Links for KLHDC10

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLHDC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLHDC10 Gene

Publications for KLHDC10 Gene

  1. The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. (PMID: 23102700) Sekine Y. … Ichijo H. (Mol. Cell 2012) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for KLHDC10 Gene

Sources for KLHDC10 Gene