KLHDC10 Gene
protein-coding GIFtS: 43
GCID: GC07P129710
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kelch domain containing 10
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Aliases
for KLHDC10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kelch Domain Containing 101 2 | | Slim1 | | KIAA02651 3 | | PNAS-1192 | | Kelch Domain-Containing Protein 102 | | Scruin Like At The Midline Homolog2 |
Export aliases for KLHDC10 gene to outside databasesPrevious GC identifers: GC07P129498 GC07P124072 |
Summaries
for KLHDC10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KLHDC10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLHDC10 gene promoter:
Max1 GATA-1 AREB6 Max CBF-A CBF-B STAT3 c-Myc CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLHDC10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLHDC10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q32.2 Ensembl cytogenetic band: 7q32.2 HGNC cytogenetic band: 7q32.2KLHDC10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P129710: view genomic region
(about GC identifiers)
Start:
|
129,710,349 bp from pter |
End:
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129,775,560 bp from pter |
Size:
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65,212 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 129,095,715-129,160,935 |
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Proteins
for KLHDC10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLD10_HUMAN, Q6PID8 (See
protein sequence)Recommended Name: Kelch domain-containing protein 10 Size: 442 amino acids; 49098 Da
Developmental stage: Expressed in fetal brain, liver, lung, kidney and placenta
Sequence caution: Sequence=BAA13395.1; Type=Erroneous initiation;
Secondary accessions: Q86Y99 Q92554Alternative splicing: 2 isoforms: Q6PID8-1 Q6PID8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KLHDC10: NX_Q6PID8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PID8
KLHDC10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055812.1
ENSEMBL proteins: ENSP00000334140 ENSP00000420083 ENSP00000420034
Human Recombinant Protein Products for KLHDC10:
KLHDC10 Antibody Products:
Assay Products for KLHDC10: |
Protein
Domains /
Families
for KLHDC10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLHDC10 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PID8ProtoNet protein and cluster: Q6PID8 UniProtKB/Swiss-Prot: KLD10_HUMAN, Q6PID8Similarity: Contains 6 Kelch repeats |
Function
for KLHDC10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLHDC10 (NM_014997) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHDC10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC10 |
|
Pathways & Interactions
for KLHDC10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLHDC10
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/261 Interacting proteins for KLHDC10 (Q6PID83 ENSP000003341404) via UniProtKB, MINT, STRING, and/or I2D (see all 261)About this table
|
Drugs & Compounds
for KLHDC10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLHDC10
Search CenterWatch for drugs/clinical trials and news about KLHDC10 / KLD10
|
Transcripts
for KLHDC10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLHDC10 gene: NM_014997.3 Unigene Cluster for KLHDC10: Kelch domain containing 10 Hs.520710 [show with all ESTs]Unigene Representative Sequence: NM_0149974 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335420(uc003vpj.2 uc003vpk.2 uc010lmb.2) ENST00000463413
ENST00000468226 ENST00000495724
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC10
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLHDC10 (NM_014997) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLHDC10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC10 |
Additional cDNA sequence: AF268385.1 AF277175.1 AF277177.1 BC009977.2 BC036464.2 BC044884.1 D87454.1 7 DOTS entries: DT.316710 DT.97806266 DT.92432685 DT.95079754 DT.40253332 DT.95079753 DT.95218936 24/270 AceView cDNA sequences (see all 270): AA468765 W72688 BF447120 BC036464 BM312356 AA468745 AA412218 D87454 AI536633 AA829417 AA480331 BF478100 BQ436702 AA703195 BQ268309 BU184054 AA769540 AI674145 AI146839 BQ581723 R86088 BU177441 CA446815 NM_014997
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KLHDC10 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
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| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KLHDC10
|
Expression
for KLHDC10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLHDC10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCATATGATC
About this image
See KLHDC10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLHDC10
SOURCE GeneReport for Unigene cluster: Hs.520710
SABiosciences Custom PCR Arrays for KLHDC10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHDC10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLHDC10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLHDC10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLHDC10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC10 |
Orthologs
for KLHDC10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KLHDC10 gene from 8/26 species (see all 26) About this table
ENSEMBL Gene Tree for KLHDC10 (if available)
TreeFam Gene Tree for KLHDC10 (if available) |
Paralogs
for KLHDC10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLHDC10 gene
- KLHDC22 HCFC12 KLHDC32 KLHDC12 LZTR12 RABEPK2 HCFC22
KLHDC10 for paralogs About GeneDecksing
|
Genomic Variants
for KLHDC10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLHDC10 (129710349 - 129775560 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KLHDC10
1 CNV: 6573 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLHDC10 |
|
Disorders
/ Diseases
for KLHDC10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KLHDC10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLHDC10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLHDC10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
- The Kelch repeat protein KLHDC10 regulates oxidative s tress-induced ASK1 activation by suppressing PP5. (PubMed id 23102700)1 Sekine Y....Ichijo H. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST- flanking region at human chromosome 7q32. (PubMed id 14962666)2 Yamada T.... Kishino T. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KLHDC10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLHDC10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLHDC10 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KLHDC10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLHDC10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLHDC10 gene:
Search GeneIP for patents involving KLHDC10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLHDC10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KLHDC10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLHDC10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLHDC10 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KLHDC10 | | OriGene 3'-UTR Clone for KLHDC10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLHDC10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | Search Tocris compounds for KLHDC10 |
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 | | | KLHDC10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLHDC10 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLHDC10 |
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