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KLF9 Gene

protein-coding   GIFtS: 53
GCID: GC09M072999

Kruppel-Like Factor 9

(Previous name: basic transcription element binding protein 1)
(Previous symbol: BTEB1)
  See KLF9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kruppel-Like Factor 91 2     Transcription Factor BTEB12 3
BTEB11 2 3 5     BTE-Binding Protein 12 3
BTEB2 3 5     GC-Box-Binding Protein 12 3
Basic Transcription Element Binding Protein 11 2     Krueppel-Like Factor 92
Basic Transcription Element-Binding Protein 12 3     

External Ids:    HGNC: 11231   Entrez Gene: 6872   Ensembl: ENSG000001191387   OMIM: 6029025   UniProtKB: Q138863   

Export aliases for KLF9 gene to outside databases

Previous GC identifers: GC09M070230 GC09M072189 GC09M042839


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLF9 Gene:
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter.
Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC
box elements activates transcription. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLF9 Gene:
KLF9 (Kruppel-like factor 9) is a protein-coding gene. Diseases associated with KLF9 include kabuki syndrome, and endometrial carcinoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF9_HUMAN, Q13886
Function: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from
genes containing tandem repeats of GC boxes but represses genes with a single GC box

Gene Wiki entry for KLF9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF9 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   Sp1   ARP-1   E2F-2   LCR-F1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KLF9 promoter sequence
   Search Chromatin IP Primers for KLF9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q13   Ensembl cytogenetic band:  9q21.12   HGNC cytogenetic band: 9q21.11

KLF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF9 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M072999:  view genomic region     (about GC identifiers)

Start:
72,999,503 bp from pter      End:
73,029,573 bp from pter
Size:
30,071 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLF9_HUMAN, Q13886 (See protein sequence)
Recommended Name: Krueppel-like factor 9  
Size: 244 amino acids; 27235 Da
Secondary accessions: B2R943 Q16196

Explore the universe of human proteins at neXtProt for KLF9: NX_Q13886

Explore proteomics data for KLF9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLF9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001197.1  
    ENSEMBL proteins: 
     ENSP00000366330  

    KLF9 Human Recombinant Protein Products:

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    antibodies-online proteins for KLF9 (5 products) 

     
    antibodies-online peptides for KLF9

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    antibodies-online antibodies for KLF9 (33 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q13886

    ProtoNet protein and cluster: Q13886

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: KLF9_HUMAN, Q13886
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with KLF9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF9_HUMAN, Q13886
    Function: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from
    genes containing tandem repeats of GC boxes but represses genes with a single GC box

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS1356762
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with KLF9           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Klf9):
     behavior/neurological 

    Find genes that share phenotypes with KLF9           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KLF9

    miRNA
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    miRTarBase miRNAs that target KLF9:
    hsa-mir-93-5p (MIRT028119), hsa-mir-335-5p (MIRT018674), hsa-mir-130b-3p (MIRT020267), hsa-mir-218-5p (MIRT024219), hsa-mir-33a-5p (MIRT028240), hsa-mir-124-3p (MIRT022972), hsa-mir-200c-3p (MIRT006886), hsa-mir-221-3p (MIRT024152), hsa-mir-21-5p (MIRT031013)

    Block miRNA regulation of human, mouse, rat KLF9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF9 (see all 60):
    hsa-miR-124* hsa-miR-579 hsa-miR-549 hsa-miR-548j hsa-miR-140-5p hsa-miR-607 hsa-miR-429 hsa-let-7d
    SwitchGear 3'UTR luciferase reporter plasmidKLF9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLF9

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF9_HUMAN, Q13886: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with KLF9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLF9 About    
    See pathways by source

    SuperPathContained pathways About
    1Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    1 BioSystems Pathway for KLF9
        Diurnally regulated genes with circadian orthologs



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLF9
    Interactions:

        GeneGlobe Interaction Network for KLF9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for KLF9 (Q138863 ENSP000003663304) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PGRP064013, ENSP000003251204I2D: score=2 STRING: ENSP00000325120
    SP1P080473, ENSP000003293574I2D: score=1 STRING: ENSP00000329357
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    HDAC7ENSP000000800594STRING: ENSP00000080059
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1356762
    GO:0007566embryo implantation IEA--
    GO:0050847progesterone receptor signaling pathway IEA--

    Find genes that share ontologies with KLF9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF9

    3 Novoseek inferred chemical compound relationships for KLF9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 45.3 27 16384861 (6), 11751593 (6), 10342837 (5), 17717078 (1)
    chloramphenicol 39.4 1 8257632 (1)
    zinc 28.6 3 8479902 (1), 17548317 (1), 9721211 (1)



    Find genes that share compounds with KLF9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLF9 gene: 
    NM_001206.2  

    Unigene Cluster for KLF9:

    Kruppel-like factor 9
    Hs.150557  [show with all ESTs]
    Unigene Representative Sequence: NM_001206
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377126(uc004aht.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat KLF9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF9 (see all 60):
    hsa-miR-124* hsa-miR-579 hsa-miR-549 hsa-miR-548j hsa-miR-140-5p hsa-miR-607 hsa-miR-429 hsa-let-7d
    SwitchGear 3'UTR luciferase reporter plasmidKLF9 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat KLF9
      QuantiFast Probe-based Assays in human, mouse, rat KLF9

    Additional mRNA sequence: 

    AB451404.1 AK313631.1 BC069431.1 BC074879.2 BC074880.2 D31716.1 S72504.1 

    6 DOTS entries:

    DT.418246  DT.92434819  DT.92434820  DT.100792014  DT.95165364  DT.97812180 

    Selected AceView cDNA sequences (see all 312):

    F03196 AA424380 BQ549122 CB306556 BF059013 CA311545 BU607769 AI342161 
    BM857812 AA939089 AI522233 AI364351 BQ771906 BM856189 AI416998 CK825403 
    AW236113 BQ268308 CF529862 AI682544 AW024734 BU630576 BQ631031 BQ787843 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTCTTGA
    KLF9 Expression
    About this image


    KLF9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Ovary (Reproductive System)
             Secondary follicles
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
    KLF9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150557
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLF9 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf91 , 5 Kruppel-like factor 91, 5 94.13(n)1
    96.72(a)1
      19 (17.90 cM)5
    166011  NM_010638.41  NP_034768.21 
     231412265 
    chicken
    (Gallus gallus)
    Aves KLF91 Kruppel-like factor 9 74.17(n)
    78.79(a)
      770238  XM_003643019.2  XP_003643067.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLF96
    Kruppel-like factor 9
    60(a)
    1 ↔ 1
    2(49095337-49123764)
    African clawed frog
    (Xenopus laevis)
    Amphibia bteb1-A2 basic transcription element binding protein 1 77.8(n)    U35408.1 
    zebrafish
    (Danio rerio)
    Actinopterygii klf96
    Kruppel-like factor 9
    47(a)
    1 ↔ 1
    5(27719779-27722714) ENSDARG00000068194


    ENSEMBL Gene Tree for KLF9 (if available)
    TreeFam Gene Tree for KLF9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF9 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  
    SP22  KLF102  KLF42  SP12  KLF162  KLF122  KLF32  SP72  
    SP92  
    Selected SIMAP similar genes for KLF9 using alignment to 2 protein entries:     KLF9_HUMAN (see all proteins) (see all similar genes):
    KLF13    SP5    DKFZp686O1631    SP3    KLF11    KLF7
    TIEG2    KLF2    ZNF860    KLF1    SP4    KLF8
    SP2    ZNF76    KLF4    SP7    KLF17    SP1

    Find genes that share paralogs with KLF9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF9 (see all 640)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343771211,2
    C--72999061(+) AATCT-/CA    
       
    /CACA
    CACAC
    1 -- ds50010--------
    rs590864511,2
    C--72999087(+) CACAC-/AC    
       
    /ACAC
    TTTGA
    1 -- ds50011NA 2
    rs1133829221,2
    F--72999150(+) ACTTGC/TGTGTT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1815378681,2
    --72999418(+) ATCTTC/TGCACT 1 -- ds50010--------
    rs1870263051,2
    --72999647(+) ACTAAC/TACTGT 1 -- ut310--------
    rs794064461,2
    F--72999779(+) AACTGA/GCAAAC 1 -- ut310--------
    rs1911142551,2
    --72999785(+) CAAACG/TAATCA 1 -- ut310--------
    rs1491332891,2
    C--72999832(+) GAGAAA/GCATGA 1 -- ut310--------
    rs1833805101,2
    --73000027(+) AAATTC/TAGTTT 1 -- ut310--------
    rs559772691,2
    C,F--73000156(+) AGTCCT/CATTTG 1 -- ut313Minor allele frequency- C:0.09WA 122

    HapMap Linkage Disequilibrium report for KLF9 (72999503 - 73029573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLF9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1491500CNV Insertion17803354
    nsv428219CNV Loss18775914
    nsv831615CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF9
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602902    OMIM disorders: --

    2 diseases for KLF9:    
    About MalaCards
    kabuki syndrome    endometrial carcinoma


    Find genes that share disorders with KLF9           About GenesLikeMe

    2 Novoseek inferred disease relationships for KLF9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometrial carcinoma 54.6 9 16384861 (2), 17717078 (1), 11476943 (1), 11751593 (1)
    immunodeficiency 10.4 4 8257632 (2), 1356762 (1), 8051167 (1)


    Export disorders for KLF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF9 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with KLF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region. (PubMed id 8051167)1, 2, 9 Imataka H....Hayami M. (J. Biol. Chem. 1994)
    2. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. (PubMed id 1356762)1, 3, 9 Imataka H....Fujii-Kuriyama Y. (EMBO J. 1992)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein. (PubMed id 8291025)1, 2 Ohe N....Fujii-Kuriyama Y. (Somat. Cell Mol. Genet. 1993)
    6. Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. (PubMed id 17717078)1, 9 Velarde M.C....Simmen R.C. (Mol. Endocrinol. 2007)
    7. Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of KrA1ppel-like factor 9/basic transcription element binding protein-1. (PubMed id 16384861)1, 9 Velarde M.C....Simmen R.C. (Endocrinology 2006)
    8. Activation of the human immunodeficiency virus type 1 long terminal repeat by BTEB, a GC box-binding transcription factor. (PubMed id 8257632)1, 9 Imataka H....Hayami M. (AIDS Res. Hum. Retroviruses 1993)
    9. Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control. (PubMed id 8269949)1, 9 Hashimoto H....Kamataki T. (Eur. J. Biochem. 1993)
    10. The evaluation of the FOXO1, KLF9 and YT521 genes expression in human endometrial cancer. (PubMed id 23865345)1 Korani M....Maleki J. (Clin. Lab. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 687 HGNC: 1123 AceView: BTEB1 Ensembl:ENSG00000119138 euGenes: HUgn687
    ECgene: KLF9 H-InvDB: KLF9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLF9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLF9 gene:
    Search GeneIP for patents involving KLF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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