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Aliases for KLF9 Gene

Aliases for KLF9 Gene

  • Kruppel-Like Factor 9 2 3 5
  • Basic Transcription Element Binding Protein 1 2 3
  • Basic Transcription Element-Binding Protein 1 3 4
  • Transcription Factor BTEB1 3 4
  • GC-Box-Binding Protein 1 3 4
  • BTE-Binding Protein 1 3 4
  • BTEB1 3 4
  • BTEB 3 4

External Ids for KLF9 Gene

Previous HGNC Symbols for KLF9 Gene

  • BTEB1

Previous GeneCards Identifiers for KLF9 Gene

  • GC09M070230
  • GC09M072189
  • GC09M072999
  • GC09M042839

Summaries for KLF9 Gene

Entrez Gene Summary for KLF9 Gene

  • The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLF9 Gene

KLF9 (Kruppel-Like Factor 9) is a Protein Coding gene. Diseases associated with KLF9 include endometrial cancer. Among its related pathways are Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for KLF9 Gene

  • Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835).

Gene Wiki entry for KLF9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF9 Gene

Genomics for KLF9 Gene

Regulatory Elements for KLF9 Gene

Enhancers for KLF9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLF9 on UCSC Golden Path with GeneCards custom track

Promoters for KLF9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLF9 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF9 Gene

Chromosome:
9
Start:
70,384,597 bp from pter
End:
70,414,657 bp from pter
Size:
30,061 bases
Orientation:
Minus strand

Genomic View for KLF9 Gene

Genes around KLF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF9 Gene

Proteins for KLF9 Gene

  • Protein details for KLF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13886-KLF9_HUMAN
    Recommended name:
    Krueppel-like factor 9
    Protein Accession:
    Q13886
    Secondary Accessions:
    • B2R943
    • Q16196

    Protein attributes for KLF9 Gene

    Size:
    244 amino acids
    Molecular mass:
    27235 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF9 Gene

Proteomics data for KLF9 Gene at MOPED

Post-translational modifications for KLF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF9 Gene

Domains & Families for KLF9 Gene

Protein Domains for KLF9 Gene

Suggested Antigen Peptide Sequences for KLF9 Gene

Graphical View of Domain Structure for InterPro Entry

Q13886

UniProtKB/Swiss-Prot:

KLF9_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF9: view

Function for KLF9 Gene

Molecular function for KLF9 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835).
UniProtKB/Swiss-Prot Induction:
Expression is highly sensitive to glucocorticoids and shows diurnal expression patterns. A strong induction of expression seen during keratinocyte differentiation in a cortisol dependent manner.
genes like me logo Genes that share phenotypes with KLF9: view

Animal Models for KLF9 Gene

MGI Knock Outs for KLF9:

Animal Model Products

Targeted motifs for KLF9 Gene
HOMER Transcription Factor Regulatory Elements motif KLF9
  • Consensus sequence: GCCACRCCCACY Submotif: canonical Cell Type: GBM GEO ID: GSE62211

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology and Transcription Factor Targets for KLF9 Gene

Localization for KLF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF9 Gene COMPARTMENTS Subcellular localization image for KLF9 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for KLF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KLF9: view

Pathways & Interactions for KLF9 Gene

genes like me logo Genes that share pathways with KLF9: view

Pathways by source for KLF9 Gene

1 BioSystems pathway for KLF9 Gene

Gene Ontology (GO) - Biological Process for KLF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007623 circadian rhythm IEP 22711835
GO:0097067 cellular response to thyroid hormone stimulus IDA 19375645
genes like me logo Genes that share ontologies with KLF9: view

No data available for SIGNOR curated interactions for KLF9 Gene

Drugs & Compounds for KLF9 Gene

(3) Drugs for KLF9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF9: view

Transcripts for KLF9 Gene

mRNA/cDNA for KLF9 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(312) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLF9 Gene

Kruppel-like factor 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF9 Gene

No ASD Table

Relevant External Links for KLF9 Gene

GeneLoc Exon Structure for
KLF9
ECgene alternative splicing isoforms for
KLF9

Expression for KLF9 Gene

mRNA expression in normal human tissues for KLF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for KLF9 Gene Hs.150557

mRNA Expression by UniProt/SwissProt for KLF9 Gene

Q13886-KLF9_HUMAN
Tissue specificity: Epidermis (at protein level).
genes like me logo Genes that share expression patterns with KLF9: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KLF9 Gene

Orthologs for KLF9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF9 35
  • 96.86 (n)
  • 99.18 (a)
KLF9 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf9 35
  • 94.13 (n)
  • 96.72 (a)
Klf9 16
Klf9 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF9 35
  • 99.45 (n)
  • 100 (a)
KLF9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf9 35
  • 94.95 (n)
  • 96.72 (a)
dog
(Canis familiaris)
Mammalia KLF9 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF9 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF9 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF9 35
  • 74.17 (n)
  • 78.79 (a)
KLF9 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF9 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf9 35
  • 71.94 (n)
  • 75.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia bteb1-A 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1235 35
zebrafish
(Danio rerio)
Actinopterygii klf9 36
  • 47 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 36
  • 14 (a)
OneToMany
Species with no ortholog for KLF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF9 Gene

ENSEMBL:
Gene Tree for KLF9 (if available)
TreeFam:
Gene Tree for KLF9 (if available)

Paralogs for KLF9 Gene

Paralogs for KLF9 Gene

genes like me logo Genes that share paralogs with KLF9: view

Variants for KLF9 Gene

Sequence variations from dbSNP and Humsavar for KLF9 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1056448 -- 70,413,850(-) GCGGG(A/G)CCCTC utr-variant-5-prime
rs1056454 -- 70,387,327(-) ATTCT(A/G)GGCCC utr-variant-3-prime
rs1056469 -- 70,385,388(-) CAAAC(A/T)CACAT utr-variant-3-prime
rs7851391 -- 70,393,849(+) AACCC(C/T)ATCTC intron-variant
rs7858023 -- 70,407,691(+) CCTAA(C/T)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF9 Gene

Variant ID Type Subtype PubMed ID
nsv831615 CNV Gain 17160897
nsv428219 CNV Loss 18775914
esv1491500 CNV Insertion 17803354

Variation tolerance for KLF9 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 23.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF9 Gene

HapMap Linkage Disequilibrium report
KLF9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF9 Gene

Disorders for KLF9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endometrial cancer
  • endometrial cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search KLF9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF9
genes like me logo Genes that share disorders with KLF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF9 Gene

Publications for KLF9 Gene

  1. Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region. (PMID: 8051167) Imataka H. … Hayami M. (J. Biol. Chem. 1994) 3 4 23 67
  2. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. (PMID: 1356762) Imataka H. … Fujii-Kuriyama Y. (EMBO J. 1992) 2 3 23
  3. Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells. (PMID: 17717078) Velarde M.C. … Simmen R.C. (Mol. Endocrinol. 2007) 3 23
  4. Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of KrA1ppel-like factor 9/basic transcription element binding protein-1. (PMID: 16384861) Velarde M.C. … Simmen R.C. (Endocrinology 2006) 3 23
  5. Activation of the human immunodeficiency virus type 1 long terminal repeat by BTEB, a GC box-binding transcription factor. (PMID: 8257632) Imataka H. … Hayami M. (AIDS Res. Hum. Retroviruses 1993) 3 23

Products for KLF9 Gene

Sources for KLF9 Gene

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