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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KLF8 Gene

protein-coding GIFtS: 54
GCID: GC0XP056275

Kruppel-like factor 8

Explore 4 diseases affiliated with
KLF8 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kruppel-Like Factor 8¹ ²		Zinc Finger Protein 741² ³
BKLF3¹ ² ³ ⁵		DXS741¹
ZNF741¹ ² ³ ⁵		Basic Kruppel-Like Factor 3²
Basic Krueppel-Like Factor 3² ³		Krueppel-Like Factor 8²

External Ids:	HGNC: 6351¹	Entrez Gene: 11279²	Ensembl: ENSG00000102349⁷	OMIM: 300286⁵	UniProtKB: O95600³

Export aliases for KLF8 gene to outside databases

Previous GC identifers: GC0XP053239 GC0XP054197 GC0XP054864 GC0XP055226 GC0XP056141

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLF8:

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family

contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play

an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during

development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing

results in multiple transcript variants. (provided by RefSeq, Apr 2009)

UniProtKB/Swiss-Prot: KLF8_HUMAN, O95600

Function: Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of

cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase

(FAK)

Gene Wiki entry for KLF8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_011630.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLF8 gene promoter:
AML1a Nkx2-5 MEF-2A POU2F1 POU2F1a c-Myb aMEF-2 ZID LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLF8 promoter sequence

Search SABiosciences Chromatin IP Primers for KLF8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.21 Ensembl cytogenetic band: Xp11.21 HGNC cytogenetic band: Xp11.21

KLF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF8 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP056275: view genomic region (about GC identifiers)

Start:	56,258,822 bp from pter	End:	56,314,322 bp from pter
Size:	55,501 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLF8_HUMAN, O95600 (See protein sequence)

Recommended Name: Krueppel-like factor 8

Size: 359 amino acids; 39314 Da

Subunit: Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase

sumoylates KLF8

Subcellular location: Nucleus

Secondary accessions: B4DJN3 E7EQQ8 Q2M246 Q59GV5 Q5HYQ5 Q5JXP7 Q6MZJ7 Q9UGC4

Alternative splicing: 2 isoforms: O95600-1 O95600-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLF8: NX_O95600

Post-translational modifications:

Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no

effect on subcellular location¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O95600

KLF8 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001152768.1 NP_009181.2

ENSEMBL proteins:

ENSP00000417303 ENSP00000431911 ENSP00000364063

Human Recombinant Protein Products for KLF8:

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	Uscn Proteins for KLF8

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

KLF8 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLF8 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry O95600

ProtoNet protein and cluster: O95600

UniProtKB/Swiss-Prot: KLF8_HUMAN, O95600

Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family

Similarity: Contains 3 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KLF8_HUMAN, O95600

Function: Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of

cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase

(FAK)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

KLF8 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Klf8):

embryogenesis

growth/size

KLF8 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KLF8

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KLF8 Browse MicroRNA Expression Plasmids
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		hsa-miR-3607-3p hsa-let-7d hsa-miR-4328 hsa-miR-1197 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-218 hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: KLF8 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF8

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling events mediated by focal adhesion kinase

Signaling events mediated by focal adhesion kinase

1.00

1 BioSystems Pathway for KLF8

Signaling events mediated by focal adhesion kinase

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLF8

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/10 Interacting proteins for KLF8 (O95600^{2, 3} ENSP00000417303⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=1 STRING: ENSP00000262367
CTBP2	P56545³, ENSP00000311825⁴	I2D: score=2 STRING: ENSP00000311825
EP300	Q09472³, ENSP00000263253⁴	I2D: score=1 STRING: ENSP00000263253
KAT2B	Q92831³, ENSP00000263754⁴	I2D: score=1 STRING: ENSP00000263754
PARP1	P09874³, ENSP00000355759⁴	I2D: score=1 STRING: ENSP00000355759

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

KLF8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KLF8 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLF8
1 Novoseek chemical compound relationship for KLF8 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	30.6	4	10756197 (2), 15684403 (1)

Search CenterWatch for drugs/clinical trials and news about KLF8

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLF8 gene (2 alternative transcripts):

NM_001159296.1 NM_007250.4

Unigene Cluster for KLF8:

Kruppel-like factor 8

Hs.646614 [show with all ESTs]

Unigene Representative Sequence: AB209004

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000476898 ENST00000462627(uc010nkg.2 uc004dur.3 uc010nkh.3)

ENST00000468660 ENST00000358094 ENST00000374928(uc011mop.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): KLF8 Browse OriGene MicroRNA Expression Plasmids
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		hsa-miR-3607-3p hsa-let-7d hsa-miR-4328 hsa-miR-1197 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-218 hsa-miR-570

		SwitchGear 3'UTR luciferase reporter plasmid: KLF8 3' UTR sequence

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Additional cDNA sequence:

AB209004.1 AF069138.1 AK054627.1 AK296156.1 BC031355.1 BC063276.1 BC105130.1 BC112109.1

HF546207.1 HF546208.1 HF546209.1

7 DOTS entries:

DT.70101224 DT.100737358 DT.40259325 DT.101980821 DT.95362839 DT.121291247 DT.95349421

24/76 AceView cDNA sequences (see all 76):

BF434892 AA906449 T31937 BG696055 CD369012 BX474198 CD368990 T17330

AI377675 BQ026856 BC031355 CD250465 AI819448 AW013859 AA419465 BQ948858

AW299494 BF445320 CD672766 BG986595 T32014 BX098438 BX503897 AA889842

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for KLF8 About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8
SP1:					-
SP2:																					-
SP3:
SP4:

ECgene alternative splicing isoforms for KLF8

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLF8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

KLF8 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KLF8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLF8

SOURCE GeneReport for Unigene cluster: Hs.646614

UniProtKB/Swiss-Prot: KLF8_HUMAN, O95600

Tissue specificity: Ubiquitous

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KLF8 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KLF8⁶	--	56(a)	1 ↔ 1	Un(53379444-53382198)
lizard (Anolis carolinensis)	Reptilia	KLF8⁶ KLF12⁶ (see all 3)	--	59(a) 57(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	GL343577.1(287840-300606) 3(88120827-88146020)
African clawed frog (Xenopus laevis)	Amphibia	ap-2rep²	AP-2 repressor	73.49(n)		AB106877.1
zebrafish (Danio rerio)	Actinopterygii	klf12²	Kruppel-like factor 12	78.68(n)		117603 AF392993.1
honey bee (Apis mellifera)	Insecta	--	--	4(a)	possible ortholog	GroupUn.224(42583-44730)
worm (Caenorhabditis elegans)	Secernentea	F56F11.3³	zinc finger protein	72(a) (best of 3)		III(2946712-2952243) --

ENSEMBL Gene Tree for KLF8 (if available)
TreeFam Gene Tree for KLF8 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KLF8 gene

KLF1² KLF11² KLF6² KLF10² KLF4² KLF5² KLF14² KLF16²

KLF2² KLF15² KLF9² KLF12² KLF3² KLF7² KLF13²

18/20 SIMAP similar genes for KLF8 using alignment to 4 protein entries: KLF8_HUMAN (see all proteins) (see all similar genes):

KLF6 ZNF78L1 ZNF KLF13 DKFZp434J0650 ZNF702P

KLF12 KLF9 ZNF697 KLF7 ZFS-2 ZNF808

DKFZp313F0536 KLF4 ZNF72 KLF16 ZNF600 KLF3

KLF8 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for KLF8
PGOHUM00000249125 PGOHUM00000249476

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111350090^1,2	C	--	53331595(+)	`GTCTCA/GCTTTG`	1	--	int¹		2		WA CSA	3
rs183807582^1,2		--	56257013(+)	`ACAAAC/TACATA`	2	--	us2k¹		0	--	--	--	--
rs188630131^1,2		--	56257125(+)	`ATACAC/TAAGAG`	2	--	us2k¹		0	--	--	--	--
rs12859430^1,2	C,H	--	56257148(+)	`GTTTAG/CTACAT`	2	--	us2k¹		4		NS EA	418
rs73206579^1,2	C	--	56257196(+)	`ATATAA/GCTTGG`	2	--	us2k¹		0	--	--	--	--
rs60713642^1,2	C	--	56257207(+)	`CATCCC/AAGTTA`	2	--	us2k¹		1		WA	2
rs149578601^1,2		--	56257342(+)	`CCTGAA/GGAAAT`	2	--	us2k¹		0	--	--	--	--
rs180718990^1,2		--	56257412(+)	`GGAAGA/GACATG`	2	--	us2k¹		0	--	--	--	--
rs144289295^1,2		--	56257430(+)	`AAAAAA/TGGTGG`	2	--	us2k¹		0	--	--	--	--
rs185208239^1,2		--	56257473(+)	`GTAAAA/GCAACC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KLF8 (56258822 - 56314322 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLF8: --
Human Gene Mutation Database (HGMD): KLF8

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF8

DNA2.0 Custom Variant and Variant Library Synthesis for KLF8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLF8 for disorders           About GeneDecksing

OMIM gene information: 300286    OMIM disorders: --

4 diseases for KLF8:    About MalaCards

renal carcinoma hepatocellular carcinoma breast cancer carcinoma

Genetic Association Database (GAD): KLF8
Human Genome Epidemiology (HuGE) Navigator: KLF8 (1 document)

Export disorders for KLF8 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KLF8 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with KLF8)

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Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. (PubMed id 10756197)^{1, 2, 9} van Vliet J.... Crossley M. (2000)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)^{1, 4} Kanazawa A....Maeda S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. (PubMed id 12820964)^{1, 2} Zhao J.... Guan J.L. (2003)
Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation. (PubMed id 11836360)^{1, 9} Lossi A.M....Villard L. (2002)
KLF8 transcription factor participates in oncogenic transformation. (PubMed id 16832343)^{1, 9} Wang X. and Zhao J. (2007)
Lentivirus-mediated gene silencing of KLF8 reduced the proliferation and invasion of gastric cancer cells. (PubMed id 22766838)¹ Chen G....Yu Z. (2012)
Kruppel-like factor 8 (KLF8) is expressed in gliomas o f different WHO grades and is essential for tumor cell proliferation. (PubMed id 22276196)¹ Schnell O....Schichor C. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11279	HGNC: 6351	AceView: KLF8	Ensembl:ENSG00000102349	euGenes: HUgn11279
ECgene: KLF8	H-InvDB: KLF8

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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