Aliases for KLF8 Gene
External Ids for KLF8 Gene
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
GeneCards Summary for KLF8 Gene
KLF8 (Kruppel-Like Factor 8) is a Protein Coding gene. Among its related pathways are Signaling events mediated by focal adhesion kinase. An important paralog of this gene is KLF2.
UniProtKB/Swiss-Prot for KLF8 Gene
Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).