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Aliases for KLF8 Gene

Aliases for KLF8 Gene

  • Kruppel-Like Factor 8 2 3
  • ZNF741 3 4 6
  • BKLF3 3 4 6
  • Basic Krueppel-Like Factor 3 3 4
  • Zinc Finger Protein 741 3 4
  • Basic Kruppel-Like Factor 3 3
  • Krueppel-Like Factor 8 3

External Ids for KLF8 Gene

Previous GeneCards Identifiers for KLF8 Gene

  • GC0XP053239
  • GC0XP054197
  • GC0XP054864
  • GC0XP055226
  • GC0XP056141

Summaries for KLF8 Gene

Entrez Gene Summary for KLF8 Gene

  • This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for KLF8 Gene

KLF8 (Kruppel-Like Factor 8) is a Protein Coding gene. Among its related pathways are Signaling events mediated by focal adhesion kinase. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for KLF8 Gene

  • Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).

Gene Wiki entry for KLF8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF8 Gene

Genomics for KLF8 Gene

Regulatory Elements for KLF8 Gene

Genomic Location for KLF8 Gene

Start:
56,232,381 bp from pter
End:
56,287,889 bp from pter
Size:
55,509 bases
Orientation:
Plus strand

Genomic View for KLF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF8 Gene

Proteins for KLF8 Gene

  • Protein details for KLF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95600-KLF8_HUMAN
    Recommended name:
    Krueppel-like factor 8
    Protein Accession:
    O95600
    Secondary Accessions:
    • B4DJN3
    • E7EQQ8
    • L0R3U8
    • L0R4U2
    • Q2M246
    • Q59GV5
    • Q5HYQ5
    • Q5JXP7
    • Q6MZJ7
    • Q9UGC4

    Protein attributes for KLF8 Gene

    Size:
    359 amino acids
    Molecular mass:
    39314 Da
    Quaternary structure:
    • Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8.

    Alternative splice isoforms for KLF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF8 Gene

Proteomics data for KLF8 Gene at MOPED

Post-translational modifications for KLF8 Gene

  • Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF8 Gene

Antibody Products

No data available for DME Specific Peptides for KLF8 Gene

Domains for KLF8 Gene

Gene Families for KLF8 Gene

HGNC:
  • KLF :Kruppel-like transcription factors
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for KLF8 Gene

Suggested Antigen Peptide Sequences for KLF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95600

UniProtKB/Swiss-Prot:

KLF8_HUMAN :
  • O95600
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF8: view

Function for KLF8 Gene

Molecular function for KLF8 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).

Gene Ontology (GO) - Molecular Function for KLF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF8: view
genes like me logo Genes that share phenotypes with KLF8: view

Animal Model Products

miRNA for KLF8 Gene

miRTarBase miRNAs that target KLF8

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLF8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLF8 Gene

Localization for KLF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF8 Gene COMPARTMENTS Subcellular localization image for KLF8 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for KLF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF8: view

Pathways for KLF8 Gene

genes like me logo Genes that share pathways with KLF8: view

Pathways by source for KLF8 Gene

1 BioSystems pathway for KLF8 Gene

Gene Ontology (GO) - Biological Process for KLF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KLF8: view

Compounds for KLF8 Gene

(1) Novoseek inferred chemical compound relationships for KLF8 Gene

Compound -log(P) Hits PubMed IDs
zinc 30.6 3
genes like me logo Genes that share compounds with KLF8: view

Transcripts for KLF8 Gene

Unigene Clusters for KLF8 Gene

Kruppel-like factor 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLF8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for KLF8 Gene

GeneLoc Exon Structure for
KLF8
ECgene alternative splicing isoforms for
KLF8

Expression for KLF8 Gene

mRNA expression in normal human tissues for KLF8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KLF8 Gene

This gene is overexpressed in Kidney (67.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLF8 Gene

SOURCE GeneReport for Unigene cluster for KLF8 Gene Hs.646614

mRNA Expression by UniProt/SwissProt for KLF8 Gene

O95600-KLF8_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with KLF8: view

Expression partners for KLF8 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KLF8 Gene

Orthologs for KLF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF8 35
  • 90.37 (n)
  • 85.84 (a)
KLF8 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF8 35
  • 88.3 (n)
  • 84.59 (a)
KLF8 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf8 35
  • 85.54 (n)
  • 82.82 (a)
Klf8 16
Klf8 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF8 35
  • 100 (n)
  • 100 (a)
KLF8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf8 35
  • 86.01 (n)
  • 82.82 (a)
oppossum
(Monodelphis domestica)
Mammalia KLF8 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF8 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF8 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf8 35
  • 64.64 (n)
  • 64.19 (a)
Str.19926 35
African clawed frog
(Xenopus laevis)
Amphibia ap-2rep 35
zebrafish
(Danio rerio)
Actinopterygii klf12 35
si:ch211-208m1.2 35
  • 62.24 (n)
  • 60.54 (a)
KLF8 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12029 37
  • 75 (a)
CG9895 37
  • 74 (a)
CG42741 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 70 (a)
F56F11.3 37
  • 72 (a)
mua-1 37
  • 67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for KLF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF8 Gene

ENSEMBL:
Gene Tree for KLF8 (if available)
TreeFam:
Gene Tree for KLF8 (if available)

Paralogs for KLF8 Gene

Selected SIMAP similar genes for KLF8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KLF8 Gene

genes like me logo Genes that share paralogs with KLF8: view

Variants for KLF8 Gene

Sequence variations from dbSNP and Humsavar for KLF8 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs926810 -- 56,242,810(-) GTGGG(A/G)GCAAA intron-variant
rs1033565 -- 56,265,083(-) TTCAC(A/C)TGGAA intron-variant
rs1467426 -- 56,263,407(-) CTGCC(A/G)TCTTC intron-variant
rs1467427 -- 56,263,181(-) ACAGG(A/G)AGAGG intron-variant
rs2144119 -- 56,272,299(-) CAGGA(A/G)GCAGA intron-variant

Relevant External Links for KLF8 Gene

HapMap Linkage Disequilibrium report
KLF8
Human Gene Mutation Database (HGMD)
KLF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLF8 Gene

Disorders for KLF8 Gene

Relevant External Links for KLF8

Genetic Association Database (GAD)
KLF8
Human Genome Epidemiology (HuGE) Navigator
KLF8

No disorders were found for KLF8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KLF8 Gene

Publications for KLF8 Gene

  1. Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. (PMID: 10756197) van Vliet J. … Crossley M. (Nucleic Acids Res. 2000) 3 4 23
  2. Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation. (PMID: 11836360) Lossi A.M. … Villard L. (J. Med. Genet. 2002) 3 23
  3. KLF8 transcription factor participates in oncogenic transformation. (PMID: 16832343) Wang X. … Zhao J. (Oncogene 2007) 3 23
  4. Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PMID: 23134681) Camacho-Vanegas O. … Martignetti J.A. (FASEB J. 2013) 3 4
  5. Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. (PMID: 12820964) Zhao J. … Guan J.L. (Mol. Cell 2003) 3 4

Products for KLF8 Gene

Sources for KLF8 Gene

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