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Aliases for KLF8 Gene

Aliases for KLF8 Gene

  • Kruppel Like Factor 8 2 3 5
  • Basic Krueppel-Like Factor 3 3 4
  • Zinc Finger Protein 741 3 4
  • ZNF741 3 4
  • BKLF3 3 4
  • Basic Kruppel-Like Factor 3 3
  • Krueppel-Like Factor 8 3

External Ids for KLF8 Gene

Previous GeneCards Identifiers for KLF8 Gene

  • GC0XP053239
  • GC0XP054197
  • GC0XP054864
  • GC0XP055226
  • GC0XP056141

Summaries for KLF8 Gene

Entrez Gene Summary for KLF8 Gene

  • This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

GeneCards Summary for KLF8 Gene

KLF8 (Kruppel Like Factor 8) is a Protein Coding gene. Among its related pathways are Signaling events mediated by focal adhesion kinase. An important paralog of this gene is KLF12.

UniProtKB/Swiss-Prot for KLF8 Gene

  • Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).

Gene Wiki entry for KLF8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF8 Gene

Genomics for KLF8 Gene

Regulatory Elements for KLF8 Gene

Enhancers for KLF8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG055488 0.9 ENCODE 3.6 -743.0 -743029 4.1 ZNF76 SIN3A YY1 EGR1 SCRT2 CREM ZNF263 SP3 SMAD5 REST MAGEH1 KLF8 LOC101928692 USP51
GH0XG055450 0.8 ENCODE 3.6 -780.2 -780153 2.7 PKNOX1 MXI1 CREB3L1 MAX RAD21 ZBTB40 E2F1 ZNF316 POLR2A KDM5B MAGEH1 KLF8 PAGE3
GH0XG056231 0.6 ENCODE 0.7 +0.6 645 3.1 CTCF PKNOX1 MAZ KLF1 POLR2A MLLT1 KLF8 RPL23AP83
GH0XG056113 0.2 ENCODE 0.1 -118.2 -118202 1.0 GC0XP056095 KLF8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLF8 on UCSC Golden Path with GeneCards custom track

Promoters for KLF8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246780 745 2599 CTCF PKNOX1 KLF1 IKZF1 MLLT1 TBX21

Genomic Location for KLF8 Gene

Chromosome:
X
Start:
56,232,356 bp from pter
End:
56,291,527 bp from pter
Size:
59,172 bases
Orientation:
Plus strand

Genomic View for KLF8 Gene

Genes around KLF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF8 Gene

Proteins for KLF8 Gene

  • Protein details for KLF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95600-KLF8_HUMAN
    Recommended name:
    Krueppel-like factor 8
    Protein Accession:
    O95600
    Secondary Accessions:
    • B4DJN3
    • E7EQQ8
    • L0R3U8
    • L0R4U2
    • Q2M246
    • Q59GV5
    • Q5HYQ5
    • Q5JXP7
    • Q6MZJ7
    • Q9UGC4

    Protein attributes for KLF8 Gene

    Size:
    359 amino acids
    Molecular mass:
    39314 Da
    Quaternary structure:
    • Interacts with corepressor CtBP2. Interacts with PIAS1, PIAS2, AND PIAS4; the interaction with each ligase sumoylates KLF8.

    Alternative splice isoforms for KLF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF8 Gene

Post-translational modifications for KLF8 Gene

  • Sumoylation at Lys-67 represses transcriptional activity and reduces cell cycle progression into the G(1) phase. Has no effect on subcellular location.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLF8 Gene

Domains & Families for KLF8 Gene

Gene Families for KLF8 Gene

Protein Domains for KLF8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KLF8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95600

UniProtKB/Swiss-Prot:

KLF8_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF8: view

Function for KLF8 Gene

Molecular function for KLF8 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).

Gene Ontology (GO) - Molecular Function for KLF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10756197
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 10756197
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF8: view
genes like me logo Genes that share phenotypes with KLF8: view

Animal Model Products

CRISPR Products

miRNA for KLF8 Gene

miRTarBase miRNAs that target KLF8

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLF8 Gene

Localization for KLF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF8 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for KLF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with KLF8: view

Pathways & Interactions for KLF8 Gene

genes like me logo Genes that share pathways with KLF8: view

Pathways by source for KLF8 Gene

1 BioSystems pathway for KLF8 Gene

Gene Ontology (GO) - Biological Process for KLF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 10756197
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KLF8: view

No data available for SIGNOR curated interactions for KLF8 Gene

Drugs & Compounds for KLF8 Gene

(1) Drugs for KLF8 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF8: view

Transcripts for KLF8 Gene

Unigene Clusters for KLF8 Gene

Kruppel-like factor 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for KLF8 Gene

GeneLoc Exon Structure for
KLF8
ECgene alternative splicing isoforms for
KLF8

Expression for KLF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLF8 Gene

This gene is overexpressed in Kidney (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF8 Gene



Protein tissue co-expression partners for KLF8 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLF8 Gene:

KLF8

SOURCE GeneReport for Unigene cluster for KLF8 Gene:

Hs.646614

mRNA Expression by UniProt/SwissProt for KLF8 Gene:

O95600-KLF8_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for KLF8 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with KLF8: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF8 Gene

Orthologs for KLF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF8 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia KLF8 34 35
  • 90.37 (n)
dog
(Canis familiaris)
Mammalia KLF8 34 35
  • 88.3 (n)
rat
(Rattus norvegicus)
Mammalia Klf8 34
  • 86.01 (n)
mouse
(Mus musculus)
Mammalia Klf8 34 16 35
  • 85.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLF8 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF8 35
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF8 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf8 34
  • 64.64 (n)
Str.19926 34
African clawed frog
(Xenopus laevis)
Amphibia ap-2rep 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-208m1.2 34
  • 62.24 (n)
KLF8 35
  • 48 (a)
OneToOne
klf12 34
fruit fly
(Drosophila melanogaster)
Insecta CG12029 36
  • 75 (a)
CG9895 36
  • 74 (a)
CG42741 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56F11.3 36
  • 72 (a)
F53F8.1 36
  • 70 (a)
mua-1 36
  • 67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
Species where no ortholog for KLF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF8 Gene

ENSEMBL:
Gene Tree for KLF8 (if available)
TreeFam:
Gene Tree for KLF8 (if available)

Paralogs for KLF8 Gene

Paralogs for KLF8 Gene

(18) SIMAP similar genes for KLF8 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for KLF8 Gene

genes like me logo Genes that share paralogs with KLF8: view

Variants for KLF8 Gene

Sequence variations from dbSNP and Humsavar for KLF8 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs146429909 other 56,265,420(+) CTCCA(A/G)TACGT nc-transcript-variant, reference, missense
rs1000003088 -- 56,196,030(+) CAGAT(C/G)CTGAG intron-variant
rs1000005651 -- 56,004,474(+) TAGTA(A/C)CCCTA intron-variant
rs1000006091 -- 56,002,112(+) CTCCA(A/G)CTTCA intron-variant
rs1000025406 -- 56,147,543(+) TTTCA(C/T)TTATA intron-variant

Variation tolerance for KLF8 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF8 Gene

Human Gene Mutation Database (HGMD)
KLF8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLF8 Gene

Disorders for KLF8 Gene

Relevant External Links for KLF8

Genetic Association Database (GAD)
KLF8
Human Genome Epidemiology (HuGE) Navigator
KLF8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF8

No disorders were found for KLF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF8 Gene

Publications for KLF8 Gene

  1. Human Kruppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription. (PMID: 10756197) van Vliet J. … Crossley M. (Nucleic Acids Res. 2000) 3 4 22 64
  2. Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PMID: 23134681) Camacho-Vanegas O. … Martignetti J.A. (FASEB J. 2013) 3 4 64
  3. KLF8 transcription factor participates in oncogenic transformation. (PMID: 16832343) Wang X. … Zhao J. (Oncogene 2007) 3 22 64
  4. Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. (PMID: 16617055) Wei H. … Zhao J. (J. Biol. Chem. 2006) 3 4 64
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64

Products for KLF8 Gene

Sources for KLF8 Gene

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