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KLF7 Gene

protein-coding   GIFtS: 58
GCID: GC02M207909

Kruppel-Like Factor 7 (Ubiquitous)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Kruppel-Like Factor 7 (Ubiquitous)1 2
UKLF2 3 5
Krueppel-Like Factor 72
Ubiquitous Kruppel-Like Transcription Factor2
Ubiquitous Krueppel-Like Factor3

External Ids:    HGNC: 63501   Entrez Gene: 86092   Ensembl: ENSG000001182637   OMIM: 6048655   UniProtKB: O758403   
ORGUL members:         

Export aliases for KLF7 gene to outside databases

Previous GC identifers: GC02M206161 GC02M206668 GC02M208147 GC02M207770 GC02M207653 GC02M199795


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLF7 Gene:
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this
family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the
C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2
diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating
adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for KLF7 Gene:
KLF7 (Kruppel-like factor 7 (ubiquitous)) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF7_HUMAN, O75840
Function: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1
recognition sequence

Gene Wiki entry for KLF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF7 gene promoter:
         AhR   POU6F1 (c2)   Arnt   C/EBPalpha   RORalpha1   N-Myc   POU2F1   Nkx6-1   POU2F1a   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF7 promoter sequence
   Search Chromatin IP Primers for KLF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32   Ensembl cytogenetic band:  2q33.3   HGNC cytogenetic band: 2q32

KLF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF7 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M207909:  view genomic region     (about GC identifiers)

Start:
207,938,861 bp from pter      End:
208,031,991 bp from pter
Size:
93,131 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLF7_HUMAN, O75840 (See protein sequence)
Recommended Name: Krueppel-like factor 7  
Size: 302 amino acids; 33362 Da
Secondary accessions: B2RB03 B7Z4F7 C9JF04 E7EWH1 L0R4P2 Q7Z3H8 Q96E51
Alternative splicing: 6 isoforms:  O75840-1   O75840-2   O75840-3   O75840-4   O75840-5   O75840-6   

Explore the universe of human proteins at neXtProt for KLF7: NX_O75840

Explore proteomics data for KLF7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001257871.1  NP_001257872.1  NP_001257873.1  NP_003700.1  

    ENSEMBL proteins: 
     ENSP00000309570   ENSP00000387510   ENSP00000398572   ENSP00000393268   ENSP00000413590  
     ENSP00000397245   ENSP00000392015   ENSP00000412950   ENSP00000403284  

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    Cloud-Clone Corp. Proteins for KLF7

     
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    antibodies-online proteins for KLF7 (5 products) 

     
    antibodies-online peptides for KLF7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O75840

    ProtoNet protein and cluster: O75840

    UniProtKB/Swiss-Prot: KLF7_HUMAN, O75840
    Domain: The acidic N-terminal part may favor interaction with the basic domain of transcription factors
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with KLF7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF7_HUMAN, O75840
    Function: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1
    recognition sequence

         Genatlas biochemistry entry for KLF7:
    Kruppel-like factor 7 (ubiquitous),with homology to the core promoter element binding protein (COPEB)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS9774444
    GO:0008270zinc ion binding TAS9774444
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with KLF7           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klf7):
     behavior/neurological  cellular  homeostasis/metabolism  integument  mortality/aging 
     nervous system  respiratory system 

    Find genes that share phenotypes with KLF7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Klf7tm1Rmz for KLF7

       genOway: Develop your customized and physiologically relevant rodent model for KLF7

    miRNA
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    miRTarBase miRNAs that target KLF7:
    hsa-mir-335-5p (MIRT018392)

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    7 qRT-PCR Assays for microRNAs that regulate KLF7:
    hsa-miR-3910 hsa-miR-182 hsa-miR-196a* hsa-miR-146a hsa-miR-3126-3p hsa-miR-664* hsa-miR-146b-5p
    SwitchGear 3'UTR luciferase reporter plasmidKLF7 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF7_HUMAN, O75840: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with KLF7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLF7 About    
    See pathways by source

    SuperPathContained pathways About
    1Adipogenesis
    Adipogenesis


    1 BioSystems Pathway for KLF7
        Adipogenesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLF7
    Interactions:

        GeneGlobe Interaction Network for KLF7

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KLF7 (O758403 ENSP000003095704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXO38Q6PIJ63, ENSP000003420234I2D: score=3 STRING: ENSP00000342023
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    MEF2DENSP000002715554STRING: ENSP00000271555
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9774444
    GO:0007409axonogenesis ----
    GO:0007411axon guidance IEA--
    GO:0045893positive regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with KLF7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF7

    1 Novoseek inferred chemical compound relationship for KLF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 33.3 3 9774444 (2), 14644156 (1)



    Find genes that share compounds with KLF7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLF7 gene (4 alternative transcripts): 
    NM_001270942.1  NM_001270943.1  NM_001270944.1  NM_003709.3  

    Unigene Cluster for KLF7:

    Kruppel-like factor 7 (ubiquitous)
    Hs.59908  [show with all ESTs]
    Unigene Representative Sequence: NM_003709
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309446(uc002vbz.1) ENST00000421199 ENST00000423015(uc002vca.1)
    ENST00000467833 ENST00000458272 ENST00000435602 ENST00000426163 ENST00000457962
    ENST00000451244 ENST00000412414(uc010zix.1)
    miRNA
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    hsa-miR-3910 hsa-miR-182 hsa-miR-196a* hsa-miR-146a hsa-miR-3126-3p hsa-miR-664* hsa-miR-146b-5p
    SwitchGear 3'UTR luciferase reporter plasmidKLF7 3' UTR sequence
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    Additional mRNA sequence: 

    AB015132.1 AK000969.1 AK027371.1 AK297312.1 AK314439.1 BC012919.1 BX537890.1 CR542112.1 
    HF546205.1 HF546206.1 NR_073108.1 

    10 DOTS entries:

    DT.101980860  DT.95275941  DT.95100188  DT.97802829  DT.120992510  DT.120992517  DT.99937480  DT.120992523 
    DT.120992533  DT.113544 

    Selected AceView cDNA sequences (see all 145):

    BM699214 BF512456 BM678212 AW196970 BP345682 AW590584 AI968740 BQ269793 
    BQ021058 AA486055 AI383201 F02522 CA430163 BF062380 BQ020878 BC012919 
    AW297159 BQ187902 AI347026 BE671646 BU151399 AU185810 BQ185619 AA150205 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLF7 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
    SP1:                          -     -     -     -           -     -                             -     -                     
    SP2:                                            -           -     -           -     -     -     -     -                     
    SP3:              -     -     -     -     -     -     -     -     -                                                         
    SP4:                                                        -     -                                                         
    SP5:                                            -           -                                                               


    ECgene alternative splicing isoforms for KLF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCAAAGT
    KLF7 Expression
    About this image


    KLF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Brain (Nervous System)
             Cerebral Cortex
    KLF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59908

    UniProtKB/Swiss-Prot: KLF7_HUMAN, O75840
    Tissue specificity: Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain
    in the embryo

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KLF7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf71 , 5 Kruppel-like factor 7 (ubiquitous)1, 5 92.36(n)1
    96.01(a)1
      1 (32.31 cM)5
    936911  NM_033563.21  NP_291041.21 
     640294475 
    chicken
    (Gallus gallus)
    Aves KLF71 Kruppel-like factor 7 (ubiquitous) 81.87(n)
    86.82(a)
      429011  XM_004942643.1  XP_004942700.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLF76
    Kruppel-like factor 7 (ubiquitous)
    74(a)
    1 ↔ 1
    GL343208.1(149792-237692)
    African clawed frog
    (Xenopus laevis)
    Amphibia klf7-prov2 Kruppel-like factor 7 (ubiquitous) 79.02(n)    BC054963.1 
    zebrafish
    (Danio rerio)
    Actinopterygii klf7a1 Kruppel-like factor 7a 64.65(n)
    71.89(a)
      553670  NM_001020643.1  NP_001018479.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120293   -- 80(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F56F11.33 zinc finger protein 79(a)
    (best of 3)
      III(2946712-2952243)   --


    ENSEMBL Gene Tree for KLF7 (if available)
    TreeFam Gene Tree for KLF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF7 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    Selected SIMAP similar genes for KLF7 using alignment to 8 protein entries:     KLF7_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    KLF5    KLF12    KLF3    KLF2    KLF4
    KLF13    KLF1    KLF9    DKFZp686O1631    WT1    KLF6
    KLF14    ZNF78L1    KLF16    SP3    kr-znf3    SP1

    Find genes that share paralogs with KLF7           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KLF7
    PGOHUM00000237860


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF7 (see all 1945)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1145241391,2
    F--207328102(+) TCAATG/ATGATA 2 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1385539161,2
    --207328157(+) TAATAC/TTGCCA 2 -- ds50010--------
    rs1879847191,2
    --207328168(+) AGCTAC/TCTTAT 2 -- ds50010--------
    rs1164715101,2
    C,F--207328173(+) TCTTAT/CCCTTC 2 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1920239571,2
    --207328351(+) CCGTGC/TTGCCC 2 -- ds50010--------
    rs20753391,2
    C,F,A--207328386(-) TCAGCT/CGCCAC 2 -- ds500113Minor allele frequency- C:0.41EA WA NA CSA 1821
    rs1158584911,2
    C,F--207328561(+) CCATGC/TAGCAA 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1830733241,2
    --207328672(+) ACTTCC/TGTAAG 2 -- ut310--------
    rs1869991511,2
    --207328787(+) AGCTCC/GGGATG 2 -- ut310--------
    rs20753381,2
    C,H--207329038(-) AGGAGG/ATGGTT 2 -- ut3115Minor allele frequency- A:0.49EA NA WA CSA 1673

    HapMap Linkage Disequilibrium report for KLF7 (207938861 - 208031991 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273122CNV Insertion20981092
    esv269634CNV Insertion20981092
    nsv3129CNV Loss18451855

    Human Gene Mutation Database (HGMD): KLF7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF7
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604865    OMIM disorders: --


    Find genes that share disorders with KLF7           About GenesLikeMe

    Genetic Association Database (GAD): KLF7
    Human Genome Epidemiology (HuGE) Navigator: KLF7 (3 documents)

    Export disorders for KLF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF7 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with KLF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krueppel-like transcription factors. (PubMed id 9774444)1, 2, 3, 9 Matsumoto N....Terada M. (J. Biol. Chem. 1998)
    2. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4, 9 Kanazawa A....Maeda S. (Diabetologia 2005)
    3. Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PubMed id 23134681)1, 2 Camacho-Vanegas O.... Martignetti J.A. (FASEB J. 2013)
    4. Variation in the gene encoding KrA1ppel-like factor 7 influences body fat: studies of 14 818 Danes. (PubMed id 19147600)1, 4 Zobel D.P....Hansen T. (Eur. J. Endocrinol. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of opioid-regulated genes in human lymphocytic cells by differential display: upregulation of KrA1ppel-like factor 7 by morphine. (PubMed id 14644156)1, 9 Suzuki S....Chuang R.Y. (Exp. Cell Res. 2003)
    7. Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. (PubMed id 16339272)1, 9 Kawamura Y....Maeda S. (Mol. Endocrinol. 2006)
    8. A dominant mutation in FBXO38 causes distal spinal muscular atrophy with calf predominance. (PubMed id 24207122)1 Sumner C.J....Houlden H. (Am. J. Hum. Genet. 2013)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8609 HGNC: 6350 AceView: KLF7 Ensembl:ENSG00000118263 euGenes: HUgn8609
    ECgene: KLF7 H-InvDB: KLF7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLF7 gene:
    Search GeneIP for patents involving KLF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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