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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KLF7 Gene

protein-coding GIFtS: 56
GCID: GC02M207909

Kruppel-like factor 7 (ubiquitous)

Explore 2 diseases affiliated with
KLF7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kruppel-Like Factor 7 (Ubiquitous)¹ ²
UKLF¹ ² ³ ⁵
Krueppel-Like Factor 7²
Ubiquitous Kruppel-Like Transcription Factor²
Ubiquitous Krueppel-Like Factor³

External Ids:	HGNC: 6350¹	Entrez Gene: 8609²	Ensembl: ENSG00000118263⁷	OMIM: 604865⁵	UniProtKB: O75840³

Export aliases for KLF7 gene to outside databases

Previous GC identifers: GC02M206161 GC02M206668 GC02M208147 GC02M207770 GC02M207653 GC02M199795

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLF7:

The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this

family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus

that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting

insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A

pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple

transcript variants. (provided by RefSeq, Aug 2012)

UniProtKB/Swiss-Prot: KLF7_HUMAN, O75840

Function: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1

recognition sequence

Gene Wiki entry for KLF7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLF7 gene promoter:
AhR POU6F1 (c2) Arnt C/EBPalpha RORalpha1 N-Myc POU2F1 Nkx6-1 POU2F1a FOXO4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLF7 promoter sequence

Search SABiosciences Chromatin IP Primers for KLF7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32 Ensembl cytogenetic band: 2q33.3 HGNC cytogenetic band: 2q32

KLF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF7 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M207909: view genomic region (about GC identifiers)

Start:	207,938,861 bp from pter	End:	208,031,991 bp from pter
Size:	93,131 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLF7_HUMAN, O75840 (See protein sequence)

Recommended Name: Krueppel-like factor 7

Size: 302 amino acids; 33362 Da

Subcellular location: Nucleus (Probable)

Secondary accessions: B2RB03

Explore the universe of human proteins at neXtProt for KLF7: NX_O75840

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75840

KLF7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001257871.1 NP_001257872.1 NP_001257873.1 NP_003700.1

ENSEMBL proteins:

ENSP00000309570 ENSP00000387510 ENSP00000398572 ENSP00000393268 ENSP00000413590

ENSP00000397245 ENSP00000392015 ENSP00000412950 ENSP00000403284

Human Recombinant Protein Products for KLF7:

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	Novus Biologicals KLF7 Protein Novus Biologicals KLF7 Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KLF7

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

KLF7 for ontologies About GeneDecksing

KLF7 Antibody Products:

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Assay Products for KLF7:

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	Uscn ELISAs and CLIAs for KLF7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLF7 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry O75840

ProtoNet protein and cluster: O75840

UniProtKB/Swiss-Prot: KLF7_HUMAN, O75840

Domain: The acidic N-terminal part may favor interaction with the basic domain of transcription factors

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 3 C2H2-type zinc fingers

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: KLF7_HUMAN, O75840

Function: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1

recognition sequence

Genatlas biochemistry entry for KLF7:

Kruppel-like factor 7 (ubiquitous),with homology to the core promoter element binding protein (COPEB)

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003713	transcription coactivator activity	TAS	9774444
GO:0008270	zinc ion binding	IEA	--

KLF7 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Klf7):

behavior/neurological	cellular	homeostasis/metabolism	integument	mortality/aging
nervous system	respiratory system

KLF7 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Klf7^tm1Rmz for KLF7

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for KLF7

miRNA Products:		OriGene 3'-UTR Clone: KLF7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLF7
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF7:
		hsa-miR-3910 hsa-miR-182 hsa-miR-196a* hsa-miR-146a hsa-miR-3126-3p hsa-miR-664* hsa-miR-146b-5p
		SwitchGear 3'UTR luciferase reporter plasmid: KLF7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF7 (see all 7) OriGene shRNA RFP: KLF7 OriGene siRNA: KLF7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF7
		Sirion Biotech Custom design and validation of potent shRNA sequences against KLF7

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for KLF7
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KLF7 (NM_003709)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Adipogenesis

Adipogenesis

1.00

1 BioSystems Pathway for KLF7

Adipogenesis

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLF7

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for KLF7 (O75840³ ENSP00000309570⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FBXO38	Q6PIJ6³, ENSP00000342023⁴	I2D: score=3 STRING: ENSP00000342023
SUMO1	P63165³, ENSP00000376076⁴	I2D: score=1 STRING: ENSP00000376076

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	9774444
GO:0007409	axonogenesis	--	--
GO:0007411	axon guidance	IEA	--
GO:0045893	positive regulation of transcription, DNA-dependent	IEA	--

KLF7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

KLF7 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLF7
1 Novoseek chemical compound relationship for KLF7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	33.3	3	9774444 (2), 14644156 (1)

Search CenterWatch for drugs/clinical trials and news about KLF7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLF7 gene (4 alternative transcripts):

NM_001270942.1 NM_001270943.1 NM_001270944.1 NM_003709.3

Unigene Cluster for KLF7:

Kruppel-like factor 7 (ubiquitous)

Hs.59908 [show with all ESTs]

Unigene Representative Sequence: NM_003709

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000309446(uc002vbz.1) ENST00000421199 ENST00000423015(uc002vca.1)

ENST00000467833 ENST00000458272 ENST00000435602 ENST00000426163 ENST00000457962

ENST00000451244 ENST00000412414(uc010zix.1)

miRNA Products:		OriGene 3'-UTR Clone: KLF7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLF7
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF7:
		hsa-miR-3910 hsa-miR-182 hsa-miR-196a* hsa-miR-146a hsa-miR-3126-3p hsa-miR-664* hsa-miR-146b-5p
		SwitchGear 3'UTR luciferase reporter plasmid: KLF7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF7 (see all 7) OriGene shRNA RFP: KLF7 OriGene siRNA: KLF7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF7
		Sirion Biotech Custom design and validation of potent shRNA sequences against KLF7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: KLF7 (NM_003709)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLF7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat KLF7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF7

Additional cDNA sequence:

AB015132.1 AK000969.1 AK027371.1 AK297312.1 AK314439.1 BC012919.1 BX537890.1 CR542112.1

HF546205.1 HF546206.1 NR_073108.1

10 DOTS entries:

DT.101980860 DT.95275941 DT.95100188 DT.97802829 DT.120992510 DT.120992517 DT.99937480 DT.120992523

DT.120992533 DT.113544

24/145 AceView cDNA sequences (see all 145):

AI347026 AW590606 AA436526 AL120562 BQ187902 BE464475 BM699214 AA486055

BQ020878 BF062380 BQ021058 AW297159 AU117963 BQ185619 BP346374 BF512456

AW590584 AI968740 AA150205 AU185810 BE671646 BP345682 BU151399 AI351756

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for KLF7 (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	^	8	^	9a	·	9b
SP1:									-		-		-		-				-		-										-		-
SP2:															-				-		-				-		-		-		-		-
SP3:					-		-		-		-		-		-		-		-		-
SP4:																			-		-
SP5:															-				-

ECgene alternative splicing isoforms for KLF7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLF7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGCAAAGT

About this image

KLF7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Definitive endoderm-like cells (A scalable, suspensi...)

See KLF7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLF7

SOURCE GeneReport for Unigene cluster: Hs.59908

UniProtKB/Swiss-Prot: KLF7_HUMAN, O75840

Tissue specificity: Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in

the embryo

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for KLF7 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KLF7¹	Kruppel-like factor 7 (ubiquitous)	82.09(n) 87.16(a)		429011 XM_426569.3 XP_426569.3
lizard (Anolis carolinensis)	Reptilia	KLF7⁶ --	--	81(a) 1(a)	1 ↔ 1 possible ortholog	GL343208.1(200651-237692) 3(88021848-88042132)
African clawed frog (Xenopus laevis)	Amphibia	klf7-prov²	Kruppel-like factor 7 (ubiquitous)	79.02(n)		BC054963.1
zebrafish (Danio rerio)	Actinopterygii	klf7a¹	Kruppel-like factor 7a	64.89(n) 72.6(a)		553670 NM_001020643.1 NP_001018479.1
fruit fly (Drosophila melanogaster)	Insecta	CG12029³	--	80(a) (best of 2)		--
worm (Caenorhabditis elegans)	Secernentea	F56F11.3³	zinc finger protein	79(a) (best of 3)		III(2946712-2952243) --

ENSEMBL Gene Tree for KLF7 (if available)
TreeFam Gene Tree for KLF7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KLF7 gene

KLF1² KLF11² KLF6² KLF10² KLF4² KLF5² KLF14² KLF16²

KLF2² KLF15² KLF12² KLF9² KLF3² KLF13² KLF8²

18/144 SIMAP similar genes for KLF7 using alignment to 12 protein entries: KLF7_HUMAN (see all proteins) (see all similar genes):

DKFZp686N0199 DKFZp313F0536 KLF5 KLF12 KLF3 KLF4

KLF2 KLF1 KLF13 ZNF83 WT1 KLF9

ZFP64 ZNF717 ZNF544 ZNF888 GLI1 ZIC1

KLF7 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for KLF7
PGOHUM00000237860

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114524139^1,2	F	--	207938375(+)	`TCAATG/ATGATA`	5	--	ds500¹		1		WA	118
rs138553916^1,2		--	207938430(+)	`TAATAC/TTGCCA`	5	--	ds500¹		0	--	--	--	--
rs187984719^1,2		--	207938441(+)	`AGCTAC/TCTTAT`	5	--	ds500¹		0	--	--	--	--
rs116471510^1,2	C,F	--	207938446(+)	`TCTTAT/CCCTTC`	5	--	ds500¹		1		NA	120
rs192023957^1,2		--	207938624(+)	`CCGTGC/TTGCCC`	5	--	ds500¹		0	--	--	--	--
rs2075339^1,2	C,F,A	--	207938659(-)	`TCAGCT/CGCCAC`	5	--	ds500¹		13		EA WA NA CSA	1821
rs115858491^1,2	F	--	207938834(+)	`CCATGC/TAGCAA`	5	--	ds500¹		1		WA	118
rs183073324^1,2		--	207938945(+)	`ACTTCC/TGTAAG`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs57514992^1,2	C	--	207939043(+)	`TCGGG-/GAATCG`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs186999151^1,2		--	207939060(+)	`AGCTCC/GGGATG`	5	--	ut3¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for KLF7 (207938861 - 208031991 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLF7: --
Human Gene Mutation Database (HGMD): KLF7

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF7

DNA2.0 Custom Variant and Variant Library Synthesis for KLF7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLF7 for disorders           About GeneDecksing

OMIM gene information: 604865    OMIM disorders: --

2 diseases for KLF7:    About MalaCards

pancreatitis bruxism

Genetic Association Database (GAD): KLF7
Human Genome Epidemiology (HuGE) Navigator: KLF7 (3 documents)

Export disorders for KLF7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KLF7 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with KLF7)

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Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krueppel-like transcription factors. (PubMed id 9774444)^{1, 2, 3, 9} Matsumoto N....Terada M. (1998)
Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)^{1, 4, 9} Kanazawa A....Maeda S. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of opioid-regulated genes in human lymphocytic cells by differential display: upregulation of Kruppel-like factor 7 by morphine. (PubMed id 14644156)^{1, 9} Suzuki S....Chuang R.Y. (2003)
Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. (PubMed id 16339272)^{1, 9} Kawamura Y....Maeda S. (2006)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Variation in the gene encoding KrA1ppel-like factor 7 influences body fat: studies of 14 818 Danes. (PubMed id 19147600)¹ Zobel D.P....Hansen T. (2009)
A common cis-element in promoters of protein synthesis and cell cycle genes. (PubMed id 17351670)¹ Wyrwicz L.S....Ostrowski J. (2007)
Ca2+, CREB and kruppel: a novel KLF7-binding element conserved in mouse and human TRKB promoters is required for CREB-dependent transcription. (PubMed id 17553693)¹ Kingsbury T.J. and Krueger B.K. (2007)
Broad spectrum identification of SUMO substrates in m elanoma cells. (PubMed id 17549794)¹ Ganesan A.K....White M.A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8609	HGNC: 6350	AceView: KLF7	Ensembl:ENSG00000118263	euGenes: HUgn8609
ECgene: KLF7	H-InvDB: KLF7

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KLF7	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KLF7 gene
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Patent Information for KLF7 gene:
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