Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLF7 Gene

Aliases for KLF7 Gene

  • Kruppel Like Factor 7 2 3 5
  • Kruppel-Like Factor 7 (Ubiquitous) 2 3
  • Ubiquitous Kruppel-Like Factor 2 3
  • UKLF 3 4
  • Ubiquitous Kruppel-Like Transcription Factor 3
  • Ubiquitous Krueppel-Like Factor 4
  • Krueppel-Like Factor 7 3

External Ids for KLF7 Gene

Previous GeneCards Identifiers for KLF7 Gene

  • GC02M206161
  • GC02M206668
  • GC02M207909
  • GC02M208147
  • GC02M207770
  • GC02M207653
  • GC02M199795

Summaries for KLF7 Gene

Entrez Gene Summary for KLF7 Gene

  • The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for KLF7 Gene

KLF7 (Kruppel Like Factor 7) is a Protein Coding gene. Diseases associated with KLF7 include Bruxism. Among its related pathways are Adipogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is KLF6.

UniProtKB/Swiss-Prot for KLF7 Gene

  • Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.

Gene Wiki entry for KLF7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF7 Gene

Genomics for KLF7 Gene

Regulatory Elements for KLF7 Gene

Enhancers for KLF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G207138 1.7 FANTOM5 Ensembl ENCODE dbSUPER 24.7 +31.8 31784 6.5 CTCF PKNOX1 MAX ZNF384 ZIC2 RAD21 ZKSCAN1 POLR2A SCRT2 SMC3 KLF7 MIR2355 MIR1302-4 CREB1 METTL21A GC02P207126 MIR7845
GH02G207073 2 Ensembl ENCODE dbSUPER 11.6 +99.6 99572 1.8 CTCF POLR2A SCRT2 HLF RAD21 KLF7 MIR2355 PIR40017 PIR53902
GH02G207075 1.6 dbSUPER 11.5 +95.5 95469 6.2 HLF CEBPB MNT CEBPG ZFHX2 SMARCA4 POLR2A SCRT2 EGR2 KLF7 MIR2355 FASTKD2 PIR40017
GH02G207161 1.8 FANTOM5 ENCODE dbSUPER 9.6 +9.2 9187 6.9 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A ARID4B DMAP1 YY1 ZNF207 FOS MIR1302-4 KLF7 CREB1 ENSG00000240440 ENSG00000234902 METTL21A MIR7845 GC02P207126
GH02G207131 1.4 Ensembl ENCODE dbSUPER 11 +39.3 39251 7.2 ZSCAN4 RAD21 GATA2 ZNF366 FOS ZNF362 CEBPB ZEB2 ZNF398 ZNF843 MIR2355 KLF7 GC02P207126 MIR7845
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF7 Gene

Chromosome:
2
Start:
207,074,137 bp from pter
End:
207,173,851 bp from pter
Size:
99,715 bases
Orientation:
Minus strand

Genomic View for KLF7 Gene

Genes around KLF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF7 Gene

Proteins for KLF7 Gene

  • Protein details for KLF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75840-KLF7_HUMAN
    Recommended name:
    Krueppel-like factor 7
    Protein Accession:
    O75840
    Secondary Accessions:
    • B2RB03
    • B7Z4F7
    • C9JF04
    • E7EWH1
    • L0R4P2
    • Q7Z3H8
    • Q96E51

    Protein attributes for KLF7 Gene

    Size:
    302 amino acids
    Molecular mass:
    33362 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLF7 Gene

neXtProt entry for KLF7 Gene

Post-translational modifications for KLF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLF7 Gene

Domains & Families for KLF7 Gene

Gene Families for KLF7 Gene

Protein Domains for KLF7 Gene

Suggested Antigen Peptide Sequences for KLF7 Gene

Graphical View of Domain Structure for InterPro Entry

O75840

UniProtKB/Swiss-Prot:

KLF7_HUMAN :
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF7: view

Function for KLF7 Gene

Molecular function for KLF7 Gene

GENATLAS Biochemistry:
Kruppel-like factor 7 (ubiquitous),with homology to the core promoter element binding protein (COPEB)
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.

Gene Ontology (GO) - Molecular Function for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9774444
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 9774444
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9774444
genes like me logo Genes that share ontologies with KLF7: view
genes like me logo Genes that share phenotypes with KLF7: view

Animal Models for KLF7 Gene

MGI Knock Outs for KLF7:

Animal Model Products

CRISPR Products

miRNA for KLF7 Gene

miRTarBase miRNAs that target KLF7

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLF7 Gene

Localization for KLF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF7 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF7: view

Pathways & Interactions for KLF7 Gene

SuperPathway Contained pathways
1 Adipogenesis
genes like me logo Genes that share pathways with KLF7: view

Pathways by source for KLF7 Gene

1 BioSystems pathway for KLF7 Gene

Gene Ontology (GO) - Biological Process for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9774444
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with KLF7: view

No data available for SIGNOR curated interactions for KLF7 Gene

Drugs & Compounds for KLF7 Gene

(1) Drugs for KLF7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF7: view

Transcripts for KLF7 Gene

Unigene Clusters for KLF7 Gene

Kruppel-like factor 7 (ubiquitous):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: -

Relevant External Links for KLF7 Gene

GeneLoc Exon Structure for
KLF7
ECgene alternative splicing isoforms for
KLF7

Expression for KLF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLF7 Gene

This gene is overexpressed in Pancreatic juice (58.7) and Urine (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF7 Gene



Protein tissue co-expression partners for KLF7 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLF7 Gene:

KLF7

SOURCE GeneReport for Unigene cluster for KLF7 Gene:

Hs.59908

mRNA Expression by UniProt/SwissProt for KLF7 Gene:

O75840-KLF7_HUMAN
Tissue specificity: Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo.

Evidence on tissue expression from TISSUES for KLF7 Gene

  • Nervous system(4.8)
  • Heart(4.2)
genes like me logo Genes that share expression patterns with KLF7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF7 Gene

Orthologs for KLF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF7 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF7 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLF7 34 35
  • 94.81 (n)
dog
(Canis familiaris)
Mammalia KLF7 34 35
  • 94.7 (n)
mouse
(Mus musculus)
Mammalia Klf7 34 16 35
  • 92.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLF7 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF7 34 35
  • 81.87 (n)
lizard
(Anolis carolinensis)
Reptilia KLF7 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf7 34
  • 73.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia klf7-prov 34
zebrafish
(Danio rerio)
Actinopterygii klf7b 35
  • 69 (a)
OneToMany
klf7a 34 35
  • 64.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12029 36
  • 80 (a)
CG9895 36
  • 77 (a)
luna 35
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56F11.3 36
  • 79 (a)
F53F8.1 36
  • 75 (a)
mua-1 36
  • 69 (a)
klf-3 35
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG3 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3394 35
  • 40 (a)
OneToMany
Species where no ortholog for KLF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF7 Gene

ENSEMBL:
Gene Tree for KLF7 (if available)
TreeFam:
Gene Tree for KLF7 (if available)

Paralogs for KLF7 Gene

Variants for KLF7 Gene

Sequence variations from dbSNP and Humsavar for KLF7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1057518995 Uncertain significance 207,088,525(-) GAAGC(A/G)ATGAG nc-transcript-variant, reference, synonymous-codon, missense
rs1000002541 -- 207,094,799(+) TATTT(C/T)TTTTC intron-variant
rs1000010961 -- 207,142,790(+) ATGAA(A/T)GGGGT intron-variant
rs1000049011 -- 207,098,125(+) AGCAA(C/G)AAGTT intron-variant
rs1000049233 -- 207,101,622(+) GAACC(C/T)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF7 Gene

Variant ID Type Subtype PubMed ID
nsv1011347 CNV gain 25217958
nsv1138887 CNV deletion 24896259
nsv3129 CNV deletion 18451855
nsv954826 CNV duplication 24416366

Variation tolerance for KLF7 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF7 Gene

Human Gene Mutation Database (HGMD)
KLF7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF7 Gene

Disorders for KLF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bruxism
  • bruxism - teeth grinding
- elite association - COSMIC cancer census association via MalaCards
Search KLF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF7

Genetic Association Database (GAD)
KLF7
Human Genome Epidemiology (HuGE) Navigator
KLF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF7
genes like me logo Genes that share disorders with KLF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF7 Gene

Publications for KLF7 Gene

  1. Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krueppel-like transcription factors. (PMID: 9774444) Matsumoto N. … Terada M. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PMID: 15937668) Kanazawa A. … Maeda S. (Diabetologia 2005) 3 22 46 64
  3. Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PMID: 23134681) Camacho-Vanegas O. … Martignetti J.A. (FASEB J. 2013) 3 4 64
  4. Variation in the gene encoding KrA1ppel-like factor 7 influences body fat: studies of 14 818 Danes. (PMID: 19147600) Zobel D.P. … Hansen T. (Eur. J. Endocrinol. 2009) 3 46 64
  5. Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. (PMID: 16339272) Kawamura Y. … Maeda S. (Mol. Endocrinol. 2006) 3 22 64

Products for KLF7 Gene

Sources for KLF7 Gene

Content
Loading form....