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Aliases for KLF7 Gene

Aliases for KLF7 Gene

  • Kruppel-Like Factor 7 (Ubiquitous) 2 3
  • UKLF 3 4 6
  • Ubiquitous Kruppel-Like Transcription Factor 3
  • Ubiquitous Krueppel-Like Factor 4
  • Krueppel-Like Factor 7 3

External Ids for KLF7 Gene

Previous GeneCards Identifiers for KLF7 Gene

  • GC02M206161
  • GC02M206668
  • GC02M207909
  • GC02M208147
  • GC02M207770
  • GC02M207653
  • GC02M199795

Summaries for KLF7 Gene

Entrez Gene Summary for KLF7 Gene

  • The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for KLF7 Gene

KLF7 (Kruppel-Like Factor 7 (Ubiquitous)) is a Protein Coding gene. Among its related pathways are Adipogenesis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for KLF7 Gene

  • Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence

Gene Wiki entry for KLF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF7 Gene

Genomics for KLF7 Gene

Regulatory Elements for KLF7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLF7 Gene

Start:
207,074,137 bp from pter
End:
207,167,267 bp from pter
Size:
93,131 bases
Orientation:
Minus strand

Genomic View for KLF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF7 Gene

Proteins for KLF7 Gene

  • Protein details for KLF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75840-KLF7_HUMAN
    Recommended name:
    Krueppel-like factor 7
    Protein Accession:
    O75840
    Secondary Accessions:
    • B2RB03
    • B7Z4F7
    • C9JF04
    • E7EWH1
    • L0R4P2
    • Q7Z3H8
    • Q96E51

    Protein attributes for KLF7 Gene

    Size:
    302 amino acids
    Molecular mass:
    33362 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLF7 Gene

neXtProt entry for KLF7 Gene

Proteomics data for KLF7 Gene at MOPED

Post-translational modifications for KLF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for KLF7 Gene

Domains for KLF7 Gene

Gene Families for KLF7 Gene

HGNC:
  • KLF :Kruppel-like transcription factors
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for KLF7 Gene

Suggested Antigen Peptide Sequences for KLF7 Gene

Graphical View of Domain Structure for InterPro Entry

O75840

UniProtKB/Swiss-Prot:

KLF7_HUMAN :
  • O75840
Domain:
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF7: view

Function for KLF7 Gene

Molecular function for KLF7 Gene

GENATLAS Biochemistry:
Kruppel-like factor 7 (ubiquitous),with homology to the core promoter element binding protein (COPEB)
UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence

Gene Ontology (GO) - Molecular Function for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0003713 transcription coactivator activity TAS 9774444
GO:0008270 zinc ion binding TAS 9774444
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with KLF7: view
genes like me logo Genes that share phenotypes with KLF7: view

Animal Models for KLF7 Gene

MGI Knock Outs for KLF7:

Animal Model Products

miRNA for KLF7 Gene

miRTarBase miRNAs that target KLF7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KLF7 Gene

Localization for KLF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF7 Gene COMPARTMENTS Subcellular localization image for KLF7 gene
Compartment Confidence
nucleus 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF7: view

Pathways for KLF7 Gene

SuperPathways for KLF7 Gene

Superpath Contained pathways
1 Adipogenesis
genes like me logo Genes that share pathways with KLF7: view

Pathways by source for KLF7 Gene

1 BioSystems pathway for KLF7 Gene

Gene Ontology (GO) - Biological Process for KLF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9774444
GO:0007409 axonogenesis --
GO:0007411 axon guidance IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KLF7: view

Compounds for KLF7 Gene

(1) Novoseek inferred chemical compound relationships for KLF7 Gene

Compound -log(P) Hits PubMed IDs
zinc 33.3 3
genes like me logo Genes that share compounds with KLF7: view

Transcripts for KLF7 Gene

Unigene Clusters for KLF7 Gene

Kruppel-like factor 7 (ubiquitous):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLF7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: -

Relevant External Links for KLF7 Gene

GeneLoc Exon Structure for
KLF7
ECgene alternative splicing isoforms for
KLF7

Expression for KLF7 Gene

mRNA expression in normal human tissues for KLF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for KLF7 Gene

This gene is overexpressed in Pancreatic juice (58.7) and Urine (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLF7 Gene

SOURCE GeneReport for Unigene cluster for KLF7 Gene Hs.59908

mRNA Expression by UniProt/SwissProt for KLF7 Gene

O75840-KLF7_HUMAN
Tissue specificity: Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo
genes like me logo Genes that share expressions with KLF7: view

Expression partners for KLF7 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KLF7 Gene

Orthologs for KLF7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF7 35
  • 94.81 (n)
  • 97.02 (a)
KLF7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF7 35
  • 94.7 (n)
  • 97.68 (a)
KLF7 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf7 35
  • 92.36 (n)
  • 96.01 (a)
Klf7 16
Klf7 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF7 35
  • 100 (n)
  • 100 (a)
KLF7 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF7 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF7 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF7 35
  • 81.87 (n)
  • 86.82 (a)
KLF7 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF7 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf7 35
  • 73.87 (n)
  • 79.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia klf7-prov 35
zebrafish
(Danio rerio)
Actinopterygii klf7a 35
  • 64.65 (n)
  • 71.89 (a)
klf7a 36
  • 69 (a)
OneToMany
klf7b 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12029 37
  • 80 (a)
CG9895 37
  • 77 (a)
luna 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 75 (a)
F56F11.3 37
  • 79 (a)
mua-1 37
  • 69 (a)
klf-3 36
  • 27 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIG3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3394 36
  • 40 (a)
OneToMany
Species with no ortholog for KLF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF7 Gene

ENSEMBL:
Gene Tree for KLF7 (if available)
TreeFam:
Gene Tree for KLF7 (if available)

Paralogs for KLF7 Gene

Pseudogenes.org Pseudogenes for KLF7 Gene

genes like me logo Genes that share paralogs with KLF7: view

Variants for KLF7 Gene

Sequence variations from dbSNP and Humsavar for KLF7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs763865 -- 207,124,506(+) ATGGT(C/G/T)TCATG intron-variant
rs764487 -- 207,136,544(-) GAAGA(A/C)TGAAT intron-variant
rs768090 -- 207,138,855(+) CTTAA(A/T)TAAGG intron-variant
rs918282 -- 207,127,274(-) ATCCC(A/G)ATGGG intron-variant
rs929695 -- 207,144,812(-) ACCAC(A/G)ACTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF7 Gene

Variant ID Type Subtype PubMed ID
nsv3129 CNV Loss 18451855
esv269634 CNV Insertion 20981092
esv273122 CNV Insertion 20981092

Relevant External Links for KLF7 Gene

HapMap Linkage Disequilibrium report
KLF7
Human Gene Mutation Database (HGMD)
KLF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF7 Gene

Disorders for KLF7 Gene

Relevant External Links for KLF7

Genetic Association Database (GAD)
KLF7
Human Genome Epidemiology (HuGE) Navigator
KLF7

No disorders were found for KLF7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for KLF7 Gene

Publications for KLF7 Gene

  1. Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krueppel-like transcription factors. (PMID: 9774444) Matsumoto N. … Terada M. (J. Biol. Chem. 1998) 2 3 4 23
  2. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PMID: 15937668) Kanazawa A. … Maeda S. (Diabetologia 2005) 3 23 48
  3. Overexpression of Kruppel-like factor 7 regulates adipocytokine gene expressions in human adipocytes and inhibits glucose-induced insulin secretion in pancreatic beta-cell line. (PMID: 16339272) Kawamura Y. … Maeda S. (Mol. Endocrinol. 2006) 3 23
  4. Identification of opioid-regulated genes in human lymphocytic cells by differential display: upregulation of KrA1ppel-like factor 7 by morphine. (PMID: 14644156) Suzuki S. … Chuang R.Y. (Exp. Cell Res. 2003) 3 23
  5. Variation in the gene encoding KrA1ppel-like factor 7 influences body fat: studies of 14 818 Danes. (PMID: 19147600) Zobel D.P. … Hansen T. (Eur. J. Endocrinol. 2009) 3 48

Products for KLF7 Gene

Sources for KLF7 Gene

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