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KLF6 Gene

protein-coding   GIFtS: 61
GCID: GC10M003812

Kruppel-Like Factor 6

(Previous name: core promoter element binding protein)
(Previous symbols: BCD1, ST12, COPEB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Kruppel-Like Factor 61 2     GC-Rich Sites-Binding Factor GBF2 3
BCD11 2 3 5     ZF92 5
COPEB1 2 3 5     CBA12
ST121 2 3     GBF2
Core Promoter Element Binding Protein1 2     PAC12
GC-Rich Binding Factor1 2     Krueppel-Like Factor 62
Core Promoter Element-Binding Protein2 3     Kruppel-Like Zinc Finger Protein Zf92
Proto-Oncogene BCD12 3     Protooncogene B-Cell Derived 12
Suppressor Of Tumorigenicity 12 Protein2 3     Suppression Of Tumorigenicity 12 (Prostate)2
Transcription Factor Zf92 3     EC 2.1.1.438
CPBP2 3     EC 6.1.1.158
B-Cell-Derived Protein 12 3     

External Ids:    HGNC: 22351   Entrez Gene: 13162   Ensembl: ENSG000000670827   OMIM: 6020535   UniProtKB: Q996123   
ORGUL members:         

Export aliases for KLF6 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLF6 Gene:
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a
transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different
isoforms have been found for this gene, some of which are implicated in carcinogenesis. (provided by RefSeq, May
2009)

GeneCards Summary for KLF6 Gene:
KLF6 (Kruppel-like factor 6) is a protein-coding gene. Diseases associated with KLF6 include prostate cancer, somatic, and transient global amnesia. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and
development

Gene Wiki entry for KLF6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF6 gene promoter:
         p53   AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF6 promoter sequence
   Search Chromatin IP Primers for KLF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15

KLF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF6 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M003812:  view genomic region     (about GC identifiers)

Start:
3,818,188 bp from pter      End:
3,827,473 bp from pter
Size:
9,286 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612 (See protein sequence)
Recommended Name: Krueppel-like factor 6  
Size: 283 amino acids; 31865 Da
Sequence caution: Sequence=AAC23699.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA33050.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RE86 B4DDN0 D3DRR1 F5H3M5 Q5VUT7 Q5VUT8 Q9BT79
Alternative splicing: 3 isoforms:  Q99612-1   Q99612-2   Q99612-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLF6: NX_Q99612

Explore proteomics data for KLF6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for KLF6 (Q99612)
     GDASPDG  HQRTHTGEKPY 


    See KLF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001153596.1  NP_001153597.1  NP_001291.3  

    ENSEMBL proteins: 
     ENSP00000419923   ENSP00000419079   ENSP00000445301  

    KLF6 Human Recombinant Protein Products:

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    Novus Biologicals KLF6 Proteins
    Novus Biologicals KLF6 Lysate
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    Cloud-Clone Corp. Proteins for KLF6

    KLF6 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for KLF6

    KLF6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for KLF6
    Cloud-Clone Corp. CLIAs for KLF6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q99612

    ProtoNet protein and cluster: Q99612

    UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
    Domain: The acidic N-terminal part may favor interaction with the basic domain of transcription factors
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    KLF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF6_HUMAN, Q99612
    Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and
    development

         Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 6.1.1.152

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    KLF6 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klf6):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  integument  liver/biliary system  mortality/aging  reproductive system 

    KLF6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Klf6tm1Fdmn for KLF6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLF6
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLF6

    miRNA
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    miRTarBase miRNAs that target KLF6:
    hsa-mir-181a-5p (MIRT006939), hsa-mir-124-3p (MIRT022229), hsa-mir-148b-3p (MIRT043589)

    Block miRNA regulation of human, mouse, rat KLF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF6 (see all 86):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-3152-3p hsa-miR-4254 hsa-miR-300 hsa-miR-485-3p hsa-miR-200a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLF6
    Predesigned siRNA for gene silencing in human, mouse, rat KLF6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): KLF6 (NM_001300)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for KLF6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF6_HUMAN, Q99612: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9689109
    GO:0005737cytoplasm IEA--

    KLF6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLF6 About    
    See pathways by source

    SuperPathContained pathways About
    1Adipogenesis
    Adipogenesis


    1 BioSystems Pathway for KLF6
        Adipogenesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLF6
    Interactions:

        GeneGlobe Interaction Network for KLF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for KLF6 (Q996122, 3 ENSP000004199234) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235754O954452, 3, ENSP000003895914MINT-64538 I2D: score=5 STRING: ENSP00000389591
    ENSG00000206409O954452, 3MINT-64538 I2D: score=5 
    ENSG00000224290O954452, 3MINT-64538 I2D: score=5 
    ENSG00000226215O954452, 3MINT-64538 I2D: score=5 
    ENSG00000227567O954452, 3MINT-64538 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0019221cytokine-mediated signaling pathway IEA--
    GO:0030183B cell differentiation NAS9000136
    GO:0045893positive regulation of transcription, DNA-templated TAS9083102

    KLF6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF6

    10 Novoseek inferred chemical compound relationships for KLF6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pacap 38 75.5 2 19474768 (1), 15800375 (1)
    adenylate 70 15 10583729 (1), 10698193 (1), 11728828 (1), 14742913 (1) (see all 15)
    zinc 49.7 26 11752579 (1), 12590140 (1), 17143513 (1), 12740910 (1) (see all 16)
    fibrinogen 37.5 6 10590053 (1), 8562968 (1), 2261348 (1), 15326257 (1) (see all 5)
    adp 33.4 4 12919181 (1), 9573017 (1), 1905967 (1)
    ribonucleic acid 11.1 1 17347668 (1)
    nitric oxide 0 3 12590140 (2)
    cyclic amp 0 1 15800375 (1)
    estrogen 0 2 19707857 (2)
    serine 0 1 9083102 (1)



    KLF6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLF6 gene (4 alternative transcripts): 
    NM_001160124.1  NM_001160125.1  NM_001300.5  NM_001008490.1  

    Unigene Cluster for KLF6:

    Kruppel-like factor 6
    Hs.4055  [show with all ESTs]
    Unigene Representative Sequence: NM_001300
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461124 ENST00000497571(uc001iha.3 uc010qak.2 uc010qal.2)
    ENST00000173785 ENST00000492125 ENST00000469435(uc001ihb.2) ENST00000380946
    ENST00000542957(uc010qaj.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat KLF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF6 (see all 86):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-3152-3p hsa-miR-4254 hsa-miR-300 hsa-miR-485-3p hsa-miR-200a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF6 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF6
    Primer
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    OriGene qPCR primer pairs and template standards for KLF6
    OriGene qSTAR qPCR primer pairs in human, mouse for KLF6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF6
      QuantiTect SYBR Green Assays in human, mouse, rat KLF6
      QuantiFast Probe-based Assays in human, mouse, rat KLF6

    Additional mRNA sequence: 

    AB017493.1 AF001461.1 AK293259.1 AK316596.1 AL117595.1 BC000311.2 BC004301.1 BC015987.1 
    BT006778.1 BX537374.1 FJ619623.1 NR_027653.1 U44975.1 U51869.1 

    Selected DOTS entries (see all 25):

    DT.92358960  DT.95272154  DT.121251619  DT.92463981  DT.121251608  DT.121251437  DT.95191332  DT.97858079 
    DT.99929229  DT.95272156  DT.417863  DT.100894881  DT.95293337  DT.92463978  DT.97804318  DT.203533 
    DT.70105280  DT.95143585  DT.75162779  DT.121251441  DT.121251425  DT.121251442  DT.92463965  DT.95272170 

    Selected AceView cDNA sequences (see all 765):

    BQ949837 BU182916 BM709570 CB138778 AI086011 BM838916 BQ717527 BM744747 
    AI984237 BQ921110 AA047375 AU117520 CB112249 BQ894458 AA487037 BE327602 
    CB130889 AI088767 AW005366 AV660610 CA310006 BP379139 AI379754 T36113 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLF6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                    -                                         -                                 
    SP2:                                                                                                
    SP3:                    -                             -     -     -                                 
    SP4:                    -                                   -     -                                 
    SP5:                                                  -     -     -                                 


    ECgene alternative splicing isoforms for KLF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGAGCTGT
    KLF6 Expression
    About this image


    KLF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 26) fully expand
     
     Epithelial Cells
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Ventral/hypothalamic-like neurons
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
    KLF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.4055

    UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
    Tissue specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and
    colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain,
    spleen and thymus

        Custom PCR Arrays for KLF6
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    QuantiTect SYBR Green Assays in human, mouse, rat KLF6
    QuantiFast Probe-based Assays in human, mouse, rat KLF6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KLF6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf61 , 5 Kruppel-like factor 61, 5 87.75(n)1
    95.05(a)1
      13 (2.94 cM)5
    238491  NM_011803.21  NP_035933.21 
     58614895 
    chicken
    (Gallus gallus)
    Aves KLF61 Kruppel-like factor 6 80.65(n)
    89.61(a)
      420463  NM_001030969.1  NP_001026140.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLF66
    Kruppel-like factor 6
    84(a)
    1 ↔ 1
    6(9648830-9662243)
    African clawed frog
    (Xenopus laevis)
    Amphibia copeb-prov2 core promoter element binding protein 79.83(n)    BC044713.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.203392 Danio rerio mRNA similar to core promoter element binding more 81.02(n)    BC048893.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta luna6
    luna
    24(a)
    1 → many
    2R(6865461-6994321)


    ENSEMBL Gene Tree for KLF6 (if available)
    TreeFam Gene Tree for KLF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF6 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  SP52  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    Selected SIMAP similar genes for KLF6 using alignment to 2 protein entries:     KLF6_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    WT1    KLF3    KLF1    SP6    KLF5
    KLF8    ZFP64    KLF4    KLF16    SP3    KLF7
    A-328A3.4    KLF12    SP5    ZNF78L1    KLF13    kr-znf3

    KLF6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF6 (see all 327)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862509211,2
    --3739997(+) ACGCCC/GACGAA 4 -- ds50010--------
    rs2009766921,2
    --3740127(+) ATCTT-/AACA  
            
    AACAT
    4 -- ds50010--------
    rs1898800731,2
    --3740183(+) CCCCAC/TGTTTA 4 -- ds50010--------
    rs1382193931,2
    --3740242(+) TAGAAC/TATCCT 4 -- ds50010--------
    rs1821522431,2
    --3740247(+) TATCCC/TTGTTG 4 -- ds50010--------
    rs1436986161,2
    --3740263(+) CTAAGA/CAGCTG 4 -- ds50010--------
    rs1871139981,2
    --3740267(+) GAAGCC/TGGTTC 4 -- ds50010--------
    rs22794141,2
    C,F,A,H--3740366(+) TCCACA/GCAGTA 4 -- ds500124Minor allele frequency- G:0.24EA NS NA CSA WA 4218
    rs1910690501,2
    --3740461(+) CTTATC/TGGCCT 4 -- ds50010--------
    rs1145639521,2
    F--3740486(+) GAGATG/ATAACT 4 -- ds50011Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for KLF6 (3818188 - 3827473 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KLF6: --
    Human Gene Mutation Database (HGMD): KLF6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF6
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602053   
    OMIM disorders: 176807  613659  
    UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the
    esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It
    also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to
    adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types
    are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated
    infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually
    exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in
    sporadic disease. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate
    cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of
    prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma,
    prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid
    cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • Selected diseases for KLF6 (see all 58):    
    About MalaCards
    prostate cancer, somatic    transient global amnesia    cancer progression/metastasis    gastric cancer, somatic
    hereditary diffuse gastric cancer    diffuse gastric cancer    prostate cancer, progression and metastasis of    oligodendroglioma
    nasopharyngitis    neuroendocrine carcinoma    adenoiditis    glioblastoma multiforme
    fatty liver disease    hepatocellular carcinoma    prostate cancer    prostatitis
    septic shock    adenoid cystic carcinoma    small cell carcinoma    familial adenomatous polyposis

    1 disease from the University of Copenhagen DISEASES database for KLF6:
    Prostate cancer

    KLF6 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for KLF6 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatic mutations 63.5 25 19101139 (2), 17347589 (2), 17514651 (2), 15824733 (1) (see all 12)
    allelic loss 55.7 11 15824733 (1), 16872311 (1), 16230382 (1), 16856969 (1) (see all 7)
    prostate cancer 55.2 60 12651626 (6), 18755691 (4), 15247715 (4), 11752579 (3) (see all 21)
    hepatocellular carcinoma 45.5 26 16494780 (4), 15598377 (3), 16872311 (2), 18822210 (2) (see all 12)
    tumors 41.2 118 11752579 (4), 17514651 (4), 16702959 (4), 19097929 (3) (see all 46)
    allelic imbalance 37.1 6 15057748 (2), 17514651 (1)
    adenocarcinoma lung 37.1 1 17223258 (1)
    glioblastoma multiforme 35.6 1 12740910 (1)
    cancer 32.9 55 17143513 (5), 19097929 (4), 19333010 (2), 18174288 (2) (see all 26)
    colorectal cancer 31.2 19 16856969 (3), 17347589 (2), 16610031 (2), 15057748 (2) (see all 7)

    Genetic Association Database (GAD): KLF6
    Human Genome Epidemiology (HuGE) Navigator: KLF6 (13 documents)

    Export disorders for KLF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF6 gene, integrated from 10 sources (see all 230):
    (articles sorted by number of sources associating them with KLF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter. (PubMed id 9685731)1, 2, 3 Suzuki T....Horikoshi M. (J. Biochem. 1998)
    2. The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. (PubMed id 18515091)1, 4, 9 Miele L....Reeves H.L. (Gastroenterology 2008)
    3. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. (PubMed id 11752579)1, 2, 9 Narla G.... Friedman S.L. (Science 2001)
    4. KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations. (PubMed id 19020536)1, 4, 9 Agell L....Lloreta J. (Mod. Pathol. 2008)
    5. Genetic alterations of the KLF6 gene in gastric cancer. (PubMed id 15824733)1, 2, 9 Cho Y.G.... Park W.S. (Oncogene 2005)
    6. Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene. (PubMed id 17223258)1, 4, 9 Spinola M....Dragani T.A. (Cancer Lett. 2007)
    7. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. (PubMed id 15735005)1, 4, 9 Narla G....Martignetti J.A. (Cancer Res. 2005)
    8. Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6. (PubMed id 16598737)1, 4, 9 Bar-Shira A....Orr-Urtreger A. (Prostate 2006)
    9. A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. (PubMed id 9083102)1, 2, 9 Koritschoner N.P.... Patrito L.C. (J. Biol. Chem. 1997)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1316 HGNC: 2235 AceView: COPEB Ensembl:ENSG00000067082 euGenes: HUgn1316
    ECgene: KLF6 H-InvDB: KLF6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLF6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLF6 gene:
    Search GeneIP for patents involving KLF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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