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KLF6 Gene

protein-coding GIFtS: 57

GC10M003812

Kruppel-like factor 6
(Previous name: core promoter element binding protein )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: BCD1, ST12, COPEB)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases & Descriptions
Kruppel-like factor 6¹ ²		B-cell-derived protein 1² ³
CPBP¹ ² ³		GC-rich sites-binding factor GBF² ³
BCD1² ³ ⁵		ZF9² ⁵
COPEB² ³ ⁵		Zf9¹
GBF¹ ²		Kruppel-like zinc finger protein Zf9²
PAC1¹ ²		suppression of tumorigenicity 12 (prostate)²
core promoter element binding protein¹ ²		DKFZp686N0199²
Core promoter element-binding protein² ³		GC-rich binding factor²
Transcription factor Zf9² ³		protooncogene B-cell derived 1²
Suppressor of tumorigenicity 12 protein² ³		CBA1²
Proto-oncogene BCD1² ³		krueppel-like factor 6²
ST12² ³

External Ids:	HGNC: 2235¹	Entrez Gene: 1316²	Ensembl: ENSG00000067082⁷	UniProtKB: Q99612³

Search outside databases for aliases for KLF6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLF6:

This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a

transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different

isoforms have been found for this gene, some of which are implicated in carcinogenesis. (provided by RefSeq)

UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612

Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and

development

Gene Wiki entry for KLF6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLF6 gene upstream (promoter) region

:
NF-kappaB1 AP-1 c-Fos c-Jun C/EBPbeta NF-kappaB SRF Egr-1 STAT3 Sp1

Epigenetics:

SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for KLF6:

MePH13391-1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15

KLF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M003812: view genomic region (about GC identifiers)

Start:	3,818,188 bp from pter
End:	3,827,467 bp from pter
Size:	9,280 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.10 NT_008705.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612 (See protein sequence)

Recommended Name: Krueppel-like factor 6

Size: 283 amino acids; 31865 Da

Subcellular location: Nucleus

Sequence caution: Sequence=AAC23699.1; Type=Erroneous initiation; Sequence=BAA33050.1; Type=Erroneous initiation;

Secondary accessions: B2RE86 B4DDN0 Q5VUT7 Q5VUT8 Q9BT79

Alternative splicing: 2 isoforms: Q99612-1 Q99612-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001153596.1 NP_001153597.1 NP_001291.3

ENSEMBL proteins:

ENSP00000324925 ENSP00000419079 ENSP00000419923

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Flag-tag genes for KLF6
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for KLF6
	HuPro® and/or Recombinant Proteins from Abnova for KLF6
	Origene Purified Recombinant Human Protein: KLF6
	Novus Biologicals Proteins for KLF6
	Novus Biologicals Lysate for KLF6
	Browse Sino Biological Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	TAS	9689109
GO:0005737	cytoplasm	IEA	--

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KLF6 for ontologies About GeneDecksing

Antibodies for KLF6:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KLF6
	R&D Systems Antibodies for KLF6
	Monoclonal and Polyclonal Antibodies from Abnova (KLF6)
	Browse Origene Antibodies
	Novus Biologicals Antibodies for KLF6
	Browse antibodies at Epitomics

Assays for KLF6:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for KLF6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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KLF6 for domains About GeneDecksing

3 InterPro domains/families:

IPR015880 Znf_C2H2-like

IPR013087 Znf_C2H2/integrase_DNA-bd

IPR007087 Znf_C2H2

Graphical View of Domain Structure for InterPro Entry Q99612

ProtoNet protein and cluster: Q99612

UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612

Domain: The acidic N-terminal part may favor interaction with the basic domain of transcription factors

Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family

Similarity: Contains 3 C2H2-type zinc fingers

(According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KLF6)
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 5): KLF6 Origene shRNA RFP (see all 5): KLF6 Origene basic RS shRNA (see all 5): KLF6
		Applied Biosystems Silencer® siRNAs for KLF6
		Sigma-Aldrich siRNA for KLF6 Sigma-Aldrich shRNA Panels and shRNA for KLF6 Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		Origene GFP tagged cDNA clones in CMV expression vector (see all 3): KLF6 Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): KLF6 Origene untagged cDNA clones in CMV expression vector (see all 4): KLF6
		Browse Sino Biological Human cDNA Clones

UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612

Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and

development

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003690	double-stranded DNA binding	IEA	--
GO:0003700	transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016563	transcription activator activity	TAS	9083102 9689109
GO:0046872	metal ion binding	IEA	--

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KLF6 for ontologies About GeneDecksing

Animal Models: 9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Klf6):

cellular	embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system
lethality-prenatal/perinatal	liver/biliary system	reproductive system	skin/coat/nails

KLF6 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for KLF6

5/6 Interacting proteins for KLF6 (Q99612²) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOM	O95445²	MINT-64538
CELSR2	Q9HCU4²	MINT-65563
EHMT2	Q96KQ7²	MINT-67235
GTF3C1	Q12789²	MINT-64539
PNO1	Q9NRX1²	MINT-64541

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5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	NAS	--
GO:0019221	cytokine-mediated signaling pathway	IEA	--
GO:0030183	B cell differentiation	NAS	9000136
GO:0042060	wound healing	IEA	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA	--

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KLF6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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KLF6 for compounds About GeneDecksing

Enzo Life Sciences drugs & compounds for KLF6

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KLF6
10/39 Novoseek chemical compound relationships for KLF6 gene (see all 39 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anthocyanin	9.93	7	9878628 (4), 14742877 (3)
zinc	4.43	17	9083102 (1), 20014424 (1), 19097929 (1), 18755691 (1) (see all 17)
salicylaldehyde, semicarbazone	3.70	1	18569522 (1)
tgf beta1	3.48	3	12971963 (2), 18615188 (1)
e 125	3.34	2	15557439 (2)
adp	2.93	4	17000890 (2), 1905967 (1), 1905966 (1)
phorbol 12-myristate 13-acetate	2.70	8	19333010 (6), 9341140 (1), 12590140 (1)
fibrinogen	2.69	9	2909518 (5), 7510712 (1), 17000890 (1), 15326257 (1) (see all 5)
cotc	2.39	1	8065317 (1)
thymeleatoxin	2.25	1	19333010 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KLF6)
		Applied Biosystems Silencer® siRNAs: NM_001160124 NM_001160125 NM_001300
		Origene 29mer shRNA kits in GFP-retroviral vector (see all 5): KLF6 Origene shRNA RFP (see all 5): KLF6 Origene basic RS shRNA (see all 5): KLF6
		Sigma-Aldrich siRNA for KLF6 Sigma-Aldrich shRNA Panels and shRNA for KLF6 Explore Sigma-Aldrich super-pooled esiRNAs

microRNA:		5 SABiosciences microRNAs that regulate KLF6:
		hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-543 hsa-miR-181b

Assays:

Applied Biosystems TaqMan® Gene Expression Assays:

NM_001160124 NM_001160125 NM_001300

Clones:

Origene GFP tagged cDNA clones in CMV expression vector (see all 3): KLF6
Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): KLF6
Origene untagged cDNA clones in CMV expression vector (see all 4): KLF6

Primers:		Origene genome-wide validated SYBR primer pairs: KLF6
		SABiosciences RT2 qPCR Primer Assay for KLF6: PPH00412A

REFSEQ mRNAs for KLF6 gene (3 alternative transcripts):

NM_001160124.1 NM_001160125.1 NM_001300.5

Additional cDNA sequence: BC015987.1

24/27 DOTS entries (see all 27 ):

DT.92358960 DT.95272154 DT.121251619 DT.121251608 DT.92463981 DT.121251437 DT.95191332 DT.97858079

DT.95272156 DT.99929229 DT.95293337 DT.100894881 DT.203533 DT.97804318 DT.92463978 DT.417863

DT.121251612 DT.70105280 DT.95143585 DT.121251441 DT.75162779 DT.121251425 DT.121251442 DT.121251413

24/765 AceView cDNA sequences (see all 765 ):

AU122274 BQ052859 BU196338 BE464100 AA583425 AI056263 AI086011 BE857278

H91572 BP382558 AI128389 BQ880632 AA262347 AI379734 BM724322 BP346574

AA975533 AA508865 CB157256 AI362593 CD365403 AW440975 AA883566 BU686933

highest scoring ESTs for KLF6:

U44975 AA070983 AA218916 AA355754 AB017493 AF001461 AI363156 AI494634 AL037477 AL037844

Unigene Clusters for KLF6:

Kruppel-like factor 6

Hs.4055 [show with all ESTs], Hs.709396 [show with all ESTs]

Unigene Representative Sequences: NM_001300, BF217116

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KLF6 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	^	4	^	5	^	6a	·	6b	·	6c	·	6d
SP1:							-														-
SP2:
SP3:							-										-		-		-
SP4:							-												-		-
SP5:																	-		-		-

About this scheme

ECgene alternative splicing isoforms for KLF6

7 Ensembl transcripts including schematic representations:

ENST00000322510 ENST00000461124 ENST00000173785 ENST00000492125 ENST00000380946 ENST00000469435

ENST00000497571

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
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KLF6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KLF6

¹ / ² / ³

13 probe-sets matching KLF6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44066_s_at²^{, 3}	U95-B	1	1.00	1.00	0.89	1.41	AI887641	0.60	1.00	0.82	1
37026_at²^{, 3}	U95-A	1	1.00	1.00	0.70	0.80	U44975	1.00	1.00	1.00	1
76802_at²^{, 3}	U95-D	1	0.94	1.00	0.71	1.13	AI355637	0.60	1.00	0.82	1
63526_f_at²^{, 3}	U95-C	1	0.57	1.00	0.83	0.68	AI669667	0.60	1.00	0.82	1
224606_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
208960_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE675435	0.60	1.00	0.82	1
208961_s_at²^{, 3}	U133-A	1	0.91	1.00	--	--	AB017493	0.80	1.00	0.91	1
211610_at²^{, 3}	U133-A	1	0.64	1.00	--	--	U51869	0.80	1.00	0.91	1
224606_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208960_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555832_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208961_s_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
211610_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

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KLF6 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

About these images

CGAP SAGE TAG: AGATGAGATG TCGGAGCTGT

SOURCE GeneReport for Unigene clusters: Hs.4055 Hs.709396

UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612

Tissue specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and

colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and

thymus

Primers:		Origene genome-wide validated SYBR primer pairs: KLF6
		SABiosciences RT2 qPCR Primer Assay for KLF6: PPH00412A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for KLF6 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KLF6¹	--	Kruppel-like factor 6	88.69(n) 93.64(a)	487151 XM_544279.2 XP_544279.2
chimpanzee (Pan troglodytes)	KLF6¹	--	Kruppel-like factor 6	99.76(n) 99.65(a)	450269 XM_001141364.1 XP_001141364.1
cow (Bos taurus)	KLF6¹	--	Kruppel-like factor 6	84.56(n) 90.48(a)	505884 NM_001035271.1 NP_001030348.1
rat (Rattus norvegicus)	Klf6¹	--	Kruppel-like factor 6	87.04(n) 93.99(a)	58954 NM_031642.2 NP_113830.1
mouse (Mus musculus)	Klf6^{1, 5}	13⁵	Kruppel-like factor 6^{1, 5}	87.75(n)¹ 95.05(a)¹	23849¹ NM_011803.2¹ NP_035933.2¹ AF072403⁵ AF221848⁵ (see all 22)

About this table Species with no ortholog for KLF6

ENSEMBL Gene Tree for KLF6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for KLF6 gene

KLF1² SP8² KLF17² KLF5² KLF14² SP6² KLF15² KLF2²

KLF7² KLF13² KLF8² SP4² SP3² KLF11² SP5² KLF10²

SP2² KLF4² SP1² KLF16² KLF12² KLF9² KLF3² SP9²

SP7²

KLF6 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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10/37 NCBI SNPs in KLF6 are shown (see all 37 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 51)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Related Data				Allele Frequencies
				--	--	--		--	--				--
	rs3812715^1,2	C,F,A,H	3764838(+)	`TCCGGG/ACCACC`	1	--	ng5¹		3		NA	76
--	rs17135808^1,2	C,F	3764672(-)	`AGAAGA/GGGACA`	1	--	ng5¹		1		NA	72
	rs3829202^1,2	C,F	3764711(+)	`AGTCAT/CCCTCT`	1	--	ng5¹		1		NA	72
--	rs3812714^1,2	C,F	3764777(+)	`TGTCCC/ACCTCC`	1	--	ng5¹		2		NA EA	160
--	rs9633755^1,2	C,F	3765743(+)	`GTGTCC/GCATTT`	1	--	ng5¹		1		NA	72
--	rs75158639^1,2	F	3765560(+)	`GTAATT/CAGCGC`	1	--	ng5¹		2		NA WA	122
--	rs74983623^1,2	F	3765239(+)	`TGGCTG/CTAAGA`	1	--	ng5¹		1		WA	50
--	rs3841213^1,2	C	3765064(+)	`CGAGA-/ACTCGA`	1	--	ng5¹		0	--	--	--	--
	rs10795076^1,2	C,F,A,H	3761900(+)	`ATAAGG/TACCCA`	1	--	int¹		8		NS EA NA WA	628
	rs2388864^1,2	C,F	3762644(+)	`CGTCCC/TAGGGA`	1	--	int¹		8		NS EA NA WA	544

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HapMap Linkage Disequilibrium images for KLF6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KLF6: --

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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KLF6 for disorders About GeneDecksing

OMIM: 602053 disorders: 176807 137215

10/88 Novoseek disease relationships for KLF6 gene (see all 88 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	31.26	54	12651626 (6), 18755691 (5), 15247715 (5), 15735005 (4) (see all 22)
somatic mutation	23.07	17	19101139 (2), 17514651 (2), 17347589 (2), 17297474 (2) (see all 13)
carcinoma hepatocellular	19.69	45	17550140 (7), 16494780 (7), 17347668 (4), 16872311 (4) (see all 16)
glioblastoma multiforme	9.07	9	17514651 (5), 15064720 (3), 12740910 (1)
colorectal cancer	6.97	20	16044160 (4), 15057748 (4), 17663506 (3), 16856969 (3) (see all 8)
adenocarcinoma lung	5.08	5	19328586 (2), 18250346 (2), 17223258 (1)
keratoconus	4.92	5	16431954 (4), 17893646 (1)
prostate tumor	4.39	4	18190704 (2), 19020536 (1), 11752579 (1)
astrocytoma	4.37	6	12740910 (2), 16044160 (1), 15239146 (1), 15172998 (1) (see all 5)
dupuytrens disease	4.37	3	12794452 (3)

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Human Gene Mutation Database: KLF6
Genetic Association Database: KLF6
Human Genome Epidemiology Navigator: KLF6 (10 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/133 PubMed articles for KLF6 gene (see all 133 ):

Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter. (PubMed id 9685731)^{2, 3, 4} Suzuki T....Horikoshi M. (1998)
A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. (PubMed id 15735005)^{1, 3, 6} Narla G....Martignetti J.A. (2005)
Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. (PubMed id 9689109)^{1, 3, 4} Ratziu V.... Friedman S.L. (1998)
A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. (PubMed id 9083102)^{1, 3, 4} Koritschoner N.P.... Patrito L.C. (1997)
Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)^{3, 6} Kanazawa A....Maeda S. (2005)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization. (PubMed id 9503030)^{2, 3} Onyango P....Weith A. (1998)
Identification of Bcd, a novel proto-oncogene expressed in B-cells. (PubMed id 9000136)^{3, 4} El Rouby S. and Newcomb E.W. (1996)
Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. (PubMed id 15131018)^{1, 3} Rubinstein M....Werner H. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1316	HGNC: 2235	AceView: COPEB	Ensembl:ENSG00000067082	euGenes: HUgn1316
ECgene: KLF6	H-InvDB: KLF6

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for KLF6	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for KLF6 gene
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Patent Information for KLF6 gene:

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GeneCards and IP:

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KLF6 Gene

protein-coding GIFtS: 57

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KLF6 (Gene Symbol)
Kruppel-like factor 6
CPBP
BCD1
COPEB
GBF
PAC1
core promoter element binding protein
Core promoter element-binding protein
Transcription factor Zf9
Suppressor of tumorigenicity 12 protein
Proto-oncogene BCD1
ST12
B-cell-derived protein 1
GC-rich sites-binding factor GBF
ZF9
Zf9
Kruppel-like zinc finger protein Zf9
suppression of tumorigenicity 12 (prostate)
DKFZp686N0199
GC-rich binding factor
protooncogene B-cell derived 1
CBA1
krueppel-like factor 6

hepatocarcinogenesis
dcis
inflammatory response
growth suppression
corneal disease
microsatellite instability
retinoblastoma
germline mutation
tumor growth
cellular stress
adenocarcinoma lung
anaplastic astrocytoma
temperature-sensitive mutation
liver mass
lung cancer
ischemia
breast cancer
colorectal adenocarcinoma
nsclc
primary tumor
apoptotic dna damage
cancer cell growth
keratoconus
cancer
tumor necrosis
adenoma; pituitary
disease; liver
dupuytrens disease
growth arrest
carcinoma; nasopharyngeal
somatic mutation
cell transformation
ovarian cancer
shock
colorectal cancer
hnscc
inflammation
diabetic nephropathies
fibrosis liver
brain tumor
cancer other
prostate cancer recurrent
prostate cancer
carcinoma hepatocellular
metastasis
adenomatous polyposis coli
glioblastoma
steatosis
diffuse astrocytoma
lymph node metastasis
hepatitis c
glioblastoma multiforme
prostate tumor
gastric cancer
colon cancer
invasive carcinoma
hyperplasia
tumor progression
glioma
multiple cancer
oligodendroglioma
astrocytoma
non-alcoholic steatohepatitis
carcinoma; renal cell
squamous cell carcinoma
diabetes mellitus
disease; inflammatory bowel
chromosomal instabilities
breast tumor
pancreatic cancer
adenovirus infection
aggressive behavior
pituitary tumor
meningioma
hnpcc
tumorigenicity
colorectal tumor
metastatic prostate cancer
retroviral infection
solid tumor
xenograft model
allelic imbalance
TGA
esophageal cancer
invasive breast cancer
ovarian tumor
escc
ovarian epithelial tumor

Advanced Search (alpha)

KLF6 Gene

protein-coding GIFtS: 57

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