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Aliases for KLF6 Gene

Aliases for KLF6 Gene

  • Kruppel-Like Factor 6 2 3
  • COPEB 3 4 6
  • BCD1 3 4 6
  • Suppressor Of Tumorigenicity 12 Protein 3 4
  • Core Promoter Element Binding Protein 2 3
  • Core Promoter Element-Binding Protein 3 4
  • GC-Rich Sites-Binding Factor GBF 3 4
  • Transcription Factor Zf9 3 4
  • B-Cell-Derived Protein 1 3 4
  • GC-Rich Binding Factor 2 3
  • Proto-Oncogene BCD1 3 4
  • ST12 3 4
  • CPBP 3 4
  • ZF9 3 6
  • Suppression Of Tumorigenicity 12 (Prostate) 3
  • Kruppel-Like Zinc Finger Protein Zf9 3
  • Protooncogene B-Cell Derived 1 3
  • Krueppel-Like Factor 6 3
  • EC 2.1.1.43 64
  • EC 6.1.1.15 64
  • CBA1 3
  • PAC1 3
  • GBF 3

External Ids for KLF6 Gene

Previous Symbols for KLF6 Gene

  • BCD1
  • ST12
  • COPEB

Summaries for KLF6 Gene

Entrez Gene Summary for KLF6 Gene

  • This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]

GeneCards Summary for KLF6 Gene

KLF6 (Kruppel-Like Factor 6) is a Protein Coding gene. Diseases associated with KLF6 include transient global amnesia and prostate cancer. Among its related pathways are Adipogenesis. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for KLF6 Gene

  • Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.

Gene Wiki entry for KLF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF6 Gene

Genomics for KLF6 Gene

Genomic Location for KLF6 Gene

Start:
3,775,996 bp from pter
End:
3,785,281 bp from pter
Size:
9,286 bases
Orientation:
Minus strand

Genomic View for KLF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF6 Gene

Regulatory Elements for KLF6 Gene

Proteins for KLF6 Gene

  • Protein details for KLF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99612-KLF6_HUMAN
    Recommended name:
    Krueppel-like factor 6
    Protein Accession:
    Q99612
    Secondary Accessions:
    • B2RE86
    • B4DDN0
    • D3DRR1
    • F5H3M5
    • Q5VUT7
    • Q5VUT8
    • Q9BT79

    Protein attributes for KLF6 Gene

    Size:
    283 amino acids
    Molecular mass:
    31865 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC23699.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA33050.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF6 Gene

Proteomics data for KLF6 Gene at MOPED

Selected DME Specific Peptides for KLF6 Gene

Post-translational modifications for KLF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF6 Gene

Domains for KLF6 Gene

Gene Families for KLF6 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • KLF :Kruppel-like transcription factors

Protein Domains for KLF6 Gene

UniProtKB/Swiss-Prot:

KLF6_HUMAN
Domain:
  • The acidic N-terminal part may favor interaction with the basic domain of transcription factors:
    • Q99612
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • Q99612
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q99612
genes like me logo Genes that share domains with KLF6: view

Function for KLF6 Gene

Molecular function for KLF6 Gene

UniProtKB/Swiss-Prot Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.

Enzyme Numbers (IUBMB) for KLF6 Gene

Gene Ontology (GO) - Molecular Function for KLF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 24634218
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF6: view
genes like me logo Genes that share phenotypes with KLF6: view

Animal Models for KLF6 Gene

MGI Knock Outs for KLF6:

miRNA for KLF6 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for KLF6 Gene

Localization for KLF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF6 Gene COMPARTMENTS Subcellular localization image for KLF6 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KLF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9689109
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KLF6: view

Pathways for KLF6 Gene

SuperPathways for KLF6 Gene

Superpath Contained pathways
1 Adipogenesis
genes like me logo Genes that share pathways with KLF6: view

Pathways by source for KLF6 Gene

1 BioSystems pathway for KLF6 Gene

Gene Ontology (GO) - Biological Process for KLF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0019221 cytokine-mediated signaling pathway IEA --
GO:0030183 B cell differentiation NAS 9000136
GO:0045893 positive regulation of transcription, DNA-templated TAS 9083102
genes like me logo Genes that share ontologies with KLF6: view

Compounds for KLF6 Gene

(10) Novoseek inferred chemical compound relationships for KLF6 Gene

Compound -log(P) Hits PubMed IDs
pacap 38 75.5 2
adenylate 70 15
zinc 49.7 16
fibrinogen 37.5 5
adp 33.4 3
genes like me logo Genes that share compounds with KLF6: view

Transcripts for KLF6 Gene

Unigene Clusters for KLF6 Gene

Kruppel-like factor 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - -
SP2:
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: -
SP7: - -
SP8:

Relevant External Links for KLF6 Gene

GeneLoc Exon Structure for
KLF6
ECgene alternative splicing isoforms for
KLF6

Expression for KLF6 Gene

mRNA expression in normal human tissues for KLF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLF6 Gene

SOURCE GeneReport for Unigene cluster for KLF6 Gene Hs.4055

mRNA Expression by UniProt/SwissProt for KLF6 Gene

Q99612-KLF6_HUMAN
Tissue specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus
genes like me logo Genes that share expressions with KLF6: view

Orthologs for KLF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF6 36
  • 99.76 (n)
  • 99.65 (a)
KLF6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLF6 36
  • 87.63 (n)
  • 93.64 (a)
KLF6 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF6 36
  • 88.69 (n)
  • 93.64 (a)
KLF6 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf6 36
  • 87.75 (n)
  • 95.05 (a)
Klf6 16
Klf6 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF6 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF6 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf6 36
  • 87.04 (n)
  • 93.99 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 82 (a)
OneToMany
KLF6 36
  • 80.65 (n)
  • 89.61 (a)
KLF6 37
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia KLF6 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia copeb-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia klf6 36
  • 76.34 (n)
  • 82.44 (a)
Str.3143 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6586 36
zebrafish
(Danio rerio)
Actinopterygii Dr.20339 36
klf6a 36
  • 71.46 (n)
  • 77.34 (a)
klf6a 37
  • 76 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta luna 37
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3394 37
  • 40 (a)
OneToMany
Species with no ortholog for KLF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF6 Gene

ENSEMBL:
Gene Tree for KLF6 (if available)
TreeFam:
Gene Tree for KLF6 (if available)

Paralogs for KLF6 Gene

genes like me logo Genes that share paralogs with KLF6: view

Variants for KLF6 Gene

Sequence variations from dbSNP and Humsavar for KLF6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs7005 -- 3,777,017(-) GTTTG(A/C/G)AAAAC utr-variant-3-prime, nc-transcript-variant
rs7634 -- 3,779,135(-) GTGTG(A/T)AAGGA utr-variant-3-prime, nc-transcript-variant
rs17731 -- 3,779,369(+) ATGCC(A/G)CTTCT utr-variant-3-prime, nc-transcript-variant
rs1043003 -- 3,778,595(-) CTTCC(A/G)GAAAG utr-variant-3-prime, nc-transcript-variant
rs1043009 -- 3,777,522(-) GAATG(A/C/G)GGCAC utr-variant-3-prime, nc-transcript-variant

Relevant External Links for KLF6 Gene

HapMap Linkage Disequilibrium report
KLF6
Human Gene Mutation Database (HGMD)
KLF6

No data available for Structural Variations from Database of Genomic Variants (DGV) for KLF6 Gene

Disorders for KLF6 Gene

(2) OMIM Diseases for KLF6 Gene (602053)

UniProtKB/Swiss-Prot

KLF6_HUMAN
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269 PubMed:15824733}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:11752579}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for KLF6 Gene

(29) Novoseek inferred disease relationships for KLF6 Gene

Disease -log(P) Hits PubMed IDs
somatic mutations 63.5 15
allelic loss 55.7 7
prostate cancer 55.2 43
hepatocellular carcinoma 45.5 20
tumors 41.2 81

Relevant External Links for KLF6

Genetic Association Database (GAD)
KLF6
Human Genome Epidemiology (HuGE) Navigator
KLF6
genes like me logo Genes that share disorders with KLF6: view

Publications for KLF6 Gene

  1. A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. (PMID: 9083102) Koritschoner N.P. … Patrito L.C. (J. Biol. Chem. 1997) 3 4 23
  2. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. (PMID: 11752579) Narla G. … Friedman S.L. (Science 2001) 3 4 23
  3. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. (PMID: 15735005) Narla G. … Martignetti J.A. (Cancer Res. 2005) 3 23 49
  4. Genetic alterations of the KLF6 gene in gastric cancer. (PMID: 15824733) Cho Y.G. … Park W.S. (Oncogene 2005) 3 4 23
  5. Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6. (PMID: 16598737) Bar-Shira A. … Orr-Urtreger A. (Prostate 2006) 3 23 49

Products for KLF6 Gene

  • Addgene plasmids for KLF6

Sources for KLF6 Gene

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