Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLF6 Gene

protein-coding   GIFtS: 61
GCID: GC10M003812

Kruppel-like factor 6

(Previous name: core promoter element binding protein )
(Previous symbols: BCD1, ST12, COPEB)
 Explore 53 diseases affiliated with
KLF6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KLF6    

Aliases
for KLF6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Kruppel-Like Factor 61 2     B-Cell-Derived Protein 12 3
BCD11 2 3 5     GC-Rich Sites-Binding Factor GBF2 3
COPEB1 2 3 5     ZF92 5
CPBP1 2 3     Zf91
ST121 2 3     CBA12
GBF1 2     GC-Rich Binding Factor2
PAC11 2     Krueppel-Like Factor 62
Core Promoter Element Binding Protein1 2     Kruppel-Like Zinc Finger Protein Zf92
Core Promoter Element-Binding Protein2 3     Protooncogene B-Cell Derived 12
Proto-Oncogene BCD12 3     Suppression Of Tumorigenicity 12 (Prostate)2
Suppressor Of Tumorigenicity 12 Protein2 3     EC 2.1.1.438
Transcription Factor Zf92 3     EC 6.1.1.158

External Ids:    HGNC: 22351   Entrez Gene: 13162   Ensembl: ENSG000000670827   OMIM: 6020535   UniProtKB: Q996123   
ORGUL members:         
NONCODE:n407948    

Export aliases for KLF6 gene to outside databases


Summaries
for KLF6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KLF6:
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a
transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different
isoforms have been found for this gene, some of which are implicated in carcinogenesis. (provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and
development

Gene Wiki entry for KLF6


Genomic Views
for KLF6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLF6 gene promoter:
         p53   AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLF6 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15

KLF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF6 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M003812:  view genomic region     (about GC identifiers)

Start:
 3,818,188 bp from pter      End:
 3,827,473 bp from pter
Size:
 9,286 bases      Orientation:
 minus strand

Proteins
for KLF6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612 (See protein sequence)
Recommended Name: Krueppel-like factor 6  
Size: 283 amino acids; 31865 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAC23699.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA33050.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RE86 B4DDN0 D3DRR1 F5H3M5 Q5VUT7 Q5VUT8 Q9BT79
Alternative splicing: 3 isoforms:  Q99612-1   Q99612-2   Q99612-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLF6: NX_Q99612

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99612

    • 2 DME Specific Peptides for KLF6 (Q99612)
     GDASPDG  HQRTHTGEKPY 

    KLF6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001153596.1  NP_001153597.1  NP_001291.3  

    ENSEMBL proteins: 
     ENSP00000419923   ENSP00000419079   ENSP00000445301  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): KLF6
    OriGene Custom Protein Services for KLF6 
    GenScript Custom Purified and Recombinant Proteins Services for KLF6
    Novus Biologicals KLF6 Proteins
    Novus Biologicals KLF6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KLF6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS9689109
    GO:0005737cytoplasm IEA--


    KLF6 for ontologies           About GeneDecksing



    KLF6 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of KLF6
    R&D Systems Antibodies for KLF6
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLF6 
    GenScript Custom Superior Antibodies Services for KLF6
    Novus Biologicals KLF6 Antibodies
    Abcam antibodies for KLF6 
    Uscn Antibodies for KLF6
    ThermoFisher Antibodies for KLF6

    Assay Products for KLF6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLF6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KLF6

    Protein Domains /
    Families
    for KLF6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KLF6 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q99612

    ProtoNet protein and cluster: Q99612

    UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
    Domain: The acidic N-terminal part may favor interaction with the basic domain of transcription factors
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Function
    for KLF6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
    Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and
    development

    Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 6.1.1.152

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): KLF6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLF6
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF6 (see all 86):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-3152-3p hsa-miR-4254 hsa-miR-300 hsa-miR-485-3p hsa-miR-200a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KLF6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF6 (see all 7)
    OriGene shRNA RFP: KLF6
    OriGene siRNA: KLF6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KLF6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF6 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF6 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): KLF6 (NM_001300)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for KLF6
    Search LifeMap BioReagents cell lines for KLF6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF6

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003690double-stranded DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0008270zinc ion binding IEA--


    KLF6 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Klf6tm1Fdmn for KLF6
         10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Klf6):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  integument  liver/biliary system  mortality/aging  reproductive system 

    KLF6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KLF6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Adipogenesis
    		Adipogenesis1.00


    1 BioSystems Pathway for KLF6 
        Adipogenesis


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/21 Interacting proteins for KLF6 (Q996122, 3 ENSP000004199234) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF3C1Q127892, 3MINT-64539 I2D: score=5 
    POLA2Q141812, 3MINT-64540 I2D: score=5 
    CELSR2Q9HCU42, 3MINT-65563 I2D: score=4 
    EHMT2Q96KQ72, 3, ENSP000003646874MINT-67235 I2D: score=5 STRING: ENSP00000364687
    APOMO954452, 3, ENSP000003650814MINT-64538 I2D: score=5 STRING: ENSP00000365081
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0019221cytokine-mediated signaling pathway IEA--
    GO:0030183B cell differentiation NAS9000136
    GO:0042060wound healing ----


    KLF6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KLF6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLF6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLF6
    10 Novoseek chemical compound relationships for KLF6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pacap 38 75.5 2 19474768 (1), 15800375 (1)
    adenylate 70 15 10583729 (1), 10698193 (1), 11728828 (1), 14742913 (1) (see all 15)
    zinc 49.7 26 11752579 (1), 12590140 (1), 17143513 (1), 12740910 (1) (see all 16)
    fibrinogen 37.5 6 10590053 (1), 8562968 (1), 2261348 (1), 15326257 (1) (see all 5)
    adp 33.4 4 12919181 (1), 9573017 (1), 1905967 (1)
    ribonucleic acid 11.1 1 17347668 (1)
    nitric oxide 0 3 12590140 (2)
    cyclic amp 0 1 15800375 (1)
    estrogen 0 2 19707857 (2)
    serine 0 1 9083102 (1)

    Search CenterWatch for drugs/clinical trials and news about KLF6 

    Transcripts
    for KLF6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KLF6 gene (4 alternative transcripts): 
    NM_001160124.1  NM_001160125.1  NM_001300.5  NM_001008490.1  

    Unigene Cluster for KLF6:

    Kruppel-like factor 6
    Hs.4055  [show with all ESTs]
    Unigene Representative Sequence: NM_001300
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461124 ENST00000497571(uc001iha.3 uc010qak.2 uc010qal.2)
    ENST00000173785 ENST00000492125 ENST00000469435(uc001ihb.2) ENST00000380946
    ENST00000542957(uc010qaj.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): KLF6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLF6
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF6 (see all 86):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-3152-3p hsa-miR-4254 hsa-miR-300 hsa-miR-485-3p hsa-miR-200a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KLF6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF6 (see all 7)
    OriGene shRNA RFP: KLF6
    OriGene siRNA: KLF6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF6
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF6 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF6 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): KLF6 (NM_001300)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLF6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLF6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF6

    Additional cDNA sequence: 

    AB017493.1 AF001461.1 AK293259.1 AK316596.1 AL117595.1 BC000311.2 BC004301.1 BC015987.1 
    BT006778.1 BX537374.1 FJ619623.1 NR_027653.1 U44975.1 U51869.1 

    24/26 DOTS entries (see all 26):

    DT.92358960  DT.95272154  DT.121251619  DT.121251437  DT.92463981  DT.121251608  DT.95191332  DT.95272156 
    DT.97858079  DT.99929229  DT.417863  DT.97804318  DT.100894881  DT.95293337  DT.92463978  DT.203533 
    DT.70105280  DT.95143585  DT.75162779  DT.92463965  DT.121251441  DT.121251425  DT.121251442  DT.95272170 

    24/765 AceView cDNA sequences (see all 765):

    AW468219 BQ053145 AU118181 AA262766 AW005366 BP379139 CA314423 AI863900 
    BM702369 CA310006 AU120604 CR619427 BE302187 AI379754 CB112249 BQ892684 
    AI349522 BE327602 BQ717527 CB138778 T29920 BQ893339 AA487037 T35350 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KLF6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                    -                                         -                                 
    SP2:                                                                                                
    SP3:                    -                             -     -     -                                 
    SP4:                    -                                   -     -                                 
    SP5:                                                  -     -     -                                 


    ECgene alternative splicing isoforms for KLF6

    Expression
    for KLF6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCGGAGCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KLF6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Ventral/hypothalamic-like neurons (Generation of midbra...)

    See KLF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLF6

    SOURCE GeneReport for Unigene cluster: Hs.4055

    UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
    Tissue specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and
    colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and
    thymus

        SABiosciences Custom PCR Arrays for KLF6
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLF6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLF6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF6

    Orthologs
    for KLF6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KLF6 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KLF61 Kruppel-like factor 6 80.76(n)
    89.61(a)    		   420463  NM_001030969.1  NP_001026140.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KLF66
    --
    		 --
    		 84(a)
    6(a)
    		 1 ↔ 1
    possible ortholog
    		 6(9651281-9661334)
    3(88021848-88042132)
    African clawed frog
    (Xenopus laevis)    		 Amphibia copeb-prov2 core promoter element binding protein 79.83(n)    BC044713.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.203392 Danio rerio mRNA similar to core promoter element binding more 81.02(n)    BC048893.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta luna6
    		 luna
    		 20(a)
    		 1 → many
    		 2R(6865461-6994321)
    worm
    (Caenorhabditis elegans)    		 Secernentea klf-36
    		 MUscle Attachment abnormal family member (mua-1)
    		 19(a)
    		 possible ortholog
    		 II(6618186-6622138)


    ENSEMBL Gene Tree for KLF6 (if available)
    TreeFam Gene Tree for KLF6 (if available) 

    Paralogs
    for KLF6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLF6 gene
    KLF12  KLF112  KLF102  KLF42  KLF52  KLF142  KLF162  KLF22  
    KLF152  KLF122  KLF92  KLF32  KLF72  KLF132  KLF82  
    18/36 SIMAP similar genes for KLF6 using alignment to 2 protein entries:     KLF6_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    WT1    KLF3    KLF1    SP6    KLF5
    KLF8    ZFP64    KLF16    SP3    A-328A3.4    KLF12
    SP5    ZNF78L1    KLF4    KLF7    KLF13    kr-znf3

    KLF6 for paralogs           About GeneDecksing



    Genomic Variants
    for KLF6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/256 NCBI SNPs in KLF6 are shown (see all 256)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs32149931,2
    		C--3755013(+) GCTTG-/GAGCAA 4 -- ut31 nc-transcript-variant0--------
    rs786164631,2
    		F,--3755244(+) GGTGAT/CGAATG 4 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.03NA 120
    rs788976181,2
    		--3755659(+) TGAGAA/CAAGCC 4 -- ut31 nc-transcript-variant0--------
    rs618297251,2
    		--3755729(+) TGGAAC/TTGTTA 4 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.50NA 2
    rs790410101,2
    		C,--3755747(+) GCACAT/CAGAAG 4 -- ut31 nc-transcript-variant2Minor allele frequency- C:0.09CSA WA 120
    rs752542971,2
    		--3755784(+) GCAAAT/CCAAGT 4 -- ut31 nc-transcript-variant1Minor allele frequency- C:0.01NA 120
    rs2007559421,2
    		C--3755988(-) TCTTTG/TCTTTA 4 -- ut31 nc-transcript-variant0--------
    rs778374281,2
    		--3756360(+) TAAATT/GAAAGA 4 -- ut31 nc-transcript-variant2Minor allele frequency- G:0.09CSA WA 120
    rs735783771,2
    		C,--3756796(+) GAATTG/AGTCAG 4 -- nc-transcript-variantut311Minor allele frequency- A:0.50WA 2
    rs10500461,2
    		C,F,A,--3758068(-) TGGTAC/TCCGCC 4 -- ut31 nc-transcript-variantese36Minor allele frequency- T:0.03MN NA 312

    HapMap Linkage Disequilibrium report for KLF6 (3818188 - 3827473 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KLF6: --
    Human Gene Mutation Database (HGMD): KLF6

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF6
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF6

    Disorders / Diseases
    for KLF6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KLF6 for disorders           About GeneDecksing

    OMIM gene information: 602053   
    OMIM disorders: 176807  137215  
    UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
  • Defects in KLF6 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or
    • stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the
    small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to
    other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that
    accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and
    intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of
    the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal
    metaplasia of the stomach, most often observed in sporadic disease
  • Defects in KLF6 are a cause of prostate cancer (PC) [MIM:176807]. Prostate cancer is a malignancy originating
    • in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic
    ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small
    cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma,
    basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma

    20/53 diseases for KLF6 (see all 53):    About MalaCards
    transient global amnesia    prostatitis    cancer progression/metastasis    familial adenomatous polyposis
    gastric cancer, somatic    prostate cancer, somatic    fatty liver disease    prostate cancer
    transitional cell carcinoma    prostate cancer, progression of    basal cell carcinoma    oligodendroglioma
    prostate cancer, progression and metastasis of    hepatitis b    carcinoma    gastric cancer
    liver disease    squamous cell carcinoma    polyposis    neuroendocrine carcinoma

    1 disease from the University of Copenhagen DISEASES database for KLF6:
    Prostate cancer

    10/29 Novoseek disease relationships for KLF6 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatic mutations 63.5 25 19101139 (2), 17347589 (2), 17514651 (2), 15824733 (1) (see all 12)
    allelic loss 55.7 11 15824733 (1), 16872311 (1), 16230382 (1), 16856969 (1) (see all 7)
    prostate cancer 55.2 60 12651626 (6), 18755691 (4), 15247715 (4), 11752579 (3) (see all 21)
    hepatocellular carcinoma 45.5 26 16494780 (4), 15598377 (3), 16872311 (2), 18822210 (2) (see all 12)
    tumors 41.2 118 11752579 (4), 17514651 (4), 16702959 (4), 19097929 (3) (see all 46)
    allelic imbalance 37.1 6 15057748 (2), 17514651 (1)
    adenocarcinoma lung 37.1 1 17223258 (1)
    glioblastoma multiforme 35.6 1 12740910 (1)
    cancer 32.9 55 17143513 (5), 19097929 (4), 19333010 (2), 18174288 (2) (see all 26)
    colorectal cancer 31.2 19 16856969 (3), 17347589 (2), 16610031 (2), 15057748 (2) (see all 7)

    Genetic Association Database (GAD): KLF6
    Human Genome Epidemiology (HuGE) Navigator: KLF6 (13 documents)

    Export disorders for KLF6 gene to outside databases

    Publications
    for KLF6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLF6 gene, integrated from 9 sources (see all 208):
    (articles sorted by number of sources associating them with KLF6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter. (PubMed id 9685731)1, 2, 3 Suzuki T....Horikoshi M. (1998)
    2. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. (PubMed id 11752579)1, 2, 9 Narla G....Friedman S.L. (2001)
    3. Genetic alterations of the KLF6 gene in gastric cancer. (PubMed id 15824733)1, 2, 9 Cho Y.G....Park W.S. (2005)
    4. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. (PubMed id 15735005)1, 4, 9 Narla G....Martignetti J.A. (2005)
    5. A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. (PubMed id 9083102)1, 2, 9 Koritschoner N.P.... Patrito L.C. (1997)
    6. Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (2005)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. (PubMed id 9689109)1, 2 Ratziu V.... Friedman S.L. (1998)
    10. Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization. (PubMed id 9503030)1, 3 Onyango P....Weith A. (1998)

    External Searches for KLF6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KLF6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1316 HGNC: 2235 AceView: COPEB Ensembl:ENSG00000067082 euGenes: HUgn1316
    ECgene: KLF6 H-InvDB: KLF6

    Other Databases showing KLF6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KLF6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLF6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KLF6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KLF6 gene:
    Search GeneIP for patents involving KLF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KLF6 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KLF6
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KLF6 (KLF6)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for KLF6  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLF6  
     OriGene Protein Over-expression Lysate for KLF6   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KLF6   OriGene 3'-UTR Clone for KLF6  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLF6   OriGene Custom Protein Services for KLF6  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLF6
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF6
     GenScript Custom Purified and Recombinant Proteins Services for KLF6 GenScript cDNA clones with any tag delivered in your preferred vector for KLF6
     GenScript Custom Assay Services for KLF6 GenScript Custom Superior Antibodies Services for KLF6
     GenScript Custom overexpressing Cell Line Services for KLF6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLF6 promoter
     Search Chromatin IP Primers for KLF6
     RT2 qPCR Primer Assay in human, mouse, rat KLF6
     GNC Network for KLF6
     SABiosciences Custom PCR Arrays for KLF6
     Search Tocris compounds for KLF6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLF6 antibodies
     KLF6 proteins
     KLF6 lysates
     Antibodies for KLF6
     See all of Abcam's Antibodies, Kits and Proteins for KLF6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KLF6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KLF6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF6
     SwitchGear 3'UTR luciferase reporter plasmids for KLF6
     SwitchGear Promoter luciferase reporter plasmids for KLF6
     ThermoFisher Antibodies for KLF6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF6
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      KLF6 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4