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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLF6 Gene

protein-coding   GIFtS: 61
GCID: GC10M003812

Kruppel-Like Factor 6

(Previous name: core promoter element binding protein)
(Previous symbols: BCD1, ST12, COPEB)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Kruppel-Like Factor 61 2     GC-Rich Sites-Binding Factor GBF2 3
BCD11 2 3 5     ZF92 5
COPEB1 2 3 5     CBA12
ST121 2 3     GBF2
Core Promoter Element Binding Protein1 2     PAC12
GC-Rich Binding Factor1 2     Krueppel-Like Factor 62
Core Promoter Element-Binding Protein2 3     Kruppel-Like Zinc Finger Protein Zf92
Proto-Oncogene BCD12 3     Protooncogene B-Cell Derived 12
Suppressor Of Tumorigenicity 12 Protein2 3     Suppression Of Tumorigenicity 12 (Prostate)2
Transcription Factor Zf92 3     EC 2.1.1.438
CPBP2 3     EC 6.1.1.158
B-Cell-Derived Protein 12 3     

External Ids:    HGNC: 22351   Entrez Gene: 13162   Ensembl: ENSG000000670827   OMIM: 6020535   UniProtKB: Q996123   
ORGUL members:         
NONCODE14:n407948      

Export aliases for KLF6 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLF6 Gene:
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a
transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different
isoforms have been found for this gene, some of which are implicated in carcinogenesis. (provided by RefSeq, May
2009)

GeneCards Summary for KLF6 Gene: 
KLF6 (Kruppel-like factor 6) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with KLF6 include prostate cancer, progression and metastasis of, and transient global amnesia. GO annotations related to this gene include DNA binding and zinc ion binding. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and
development

Gene Wiki entry for KLF6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLF6 gene promoter:
         p53   AP-1   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF6 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15   Ensembl cytogenetic band:  10p15.1   HGNC cytogenetic band: 10p15

KLF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF6 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M003812:  view genomic region     (about GC identifiers)

Start:
3,818,188 bp from pter      End:
3,827,473 bp from pter
Size:
9,286 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612 (See protein sequence)
Recommended Name: Krueppel-like factor 6  
Size: 283 amino acids; 31865 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAC23699.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA33050.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RE86 B4DDN0 D3DRR1 F5H3M5 Q5VUT7 Q5VUT8 Q9BT79
Alternative splicing: 3 isoforms:  Q99612-1   Q99612-2   Q99612-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLF6: NX_Q99612

Explore proteomics data for KLF6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99612

  • 2 DME Specific Peptides for KLF6 (Q99612)
     GDASPDG  HQRTHTGEKPY 

    KLF6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLF6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001153596.1  NP_001153597.1  NP_001291.3  

    ENSEMBL proteins: 
     ENSP00000419923   ENSP00000419079   ENSP00000445301  

    Human Recombinant Protein Products for KLF6: 
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    Novus Biologicals KLF6 Lysate
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLF6 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9689109
    GO:0005737cytoplasm IEA--

    KLF6 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for KLF6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q99612

    ProtoNet protein and cluster: Q99612

    UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
    Domain: The acidic N-terminal part may favor interaction with the basic domain of transcription factors
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    KLF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF6_HUMAN, Q99612
    Function: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and
    development

         Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 6.1.1.152

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    KLF6 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klf6):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size 
     hematopoietic system  integument  liver/biliary system  mortality/aging  reproductive system 

    KLF6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Klf6tm1Fdmn for KLF6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLF6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLF6

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    SwitchGear 3'UTR luciferase reporter plasmidKLF6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLF6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Adipogenesis
    Adipogenesis


    1 BioSystems Pathway for KLF6
        Adipogenesis


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/31 Interacting proteins for KLF6 (Q996122, 3 ENSP000004199234) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235754O954452, 3, ENSP000003895914MINT-64538 I2D: score=5 STRING: ENSP00000389591
    ENSG00000206409O954452, 3MINT-64538 I2D: score=5 
    ENSG00000224290O954452, 3MINT-64538 I2D: score=5 
    ENSG00000226215O954452, 3MINT-64538 I2D: score=5 
    ENSG00000227567O954452, 3MINT-64538 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0019221cytokine-mediated signaling pathway IEA--
    GO:0030183B cell differentiation NAS9000136
    GO:0045893positive regulation of transcription, DNA-dependent TAS9083102

    KLF6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLF6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLF6

    10 Novoseek inferred chemical compound relationships for KLF6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pacap 38 75.5 2 19474768 (1), 15800375 (1)
    adenylate 70 15 10583729 (1), 10698193 (1), 11728828 (1), 14742913 (1) (see all 15)
    zinc 49.7 26 11752579 (1), 12590140 (1), 17143513 (1), 12740910 (1) (see all 16)
    fibrinogen 37.5 6 10590053 (1), 8562968 (1), 2261348 (1), 15326257 (1) (see all 5)
    adp 33.4 4 12919181 (1), 9573017 (1), 1905967 (1)
    ribonucleic acid 11.1 1 17347668 (1)
    nitric oxide 0 3 12590140 (2)
    cyclic amp 0 1 15800375 (1)
    estrogen 0 2 19707857 (2)
    serine 0 1 9083102 (1)

    Search CenterWatch for drugs/clinical trials and news about KLF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLF6 gene (4 alternative transcripts): 
    NM_001160124.1  NM_001160125.1  NM_001300.5  NM_001008490.1  

    Unigene Cluster for KLF6:

    Kruppel-like factor 6
    Hs.4055  [show with all ESTs]
    Unigene Representative Sequence: NM_001300
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461124 ENST00000497571(uc001iha.3 uc010qak.2 uc010qal.2)
    ENST00000173785 ENST00000492125 ENST00000469435(uc001ihb.2) ENST00000380946
    ENST00000542957(uc010qaj.2)

    miRNA
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    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF6 (see all 86):
    hsa-miR-140-5p hsa-miR-607 hsa-miR-3152-3p hsa-miR-4254 hsa-miR-300 hsa-miR-485-3p hsa-miR-200a hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF6 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB017493.1 AF001461.1 AK293259.1 AK316596.1 AL117595.1 BC000311.2 BC004301.1 BC015987.1 
    BT006778.1 BX537374.1 FJ619623.1 NR_027653.1 U44975.1 U51869.1 

    24/25 DOTS entries (see all 25):

    DT.92358960  DT.95272154  DT.121251619  DT.92463981  DT.121251608  DT.121251437  DT.95191332  DT.97858079 
    DT.99929229  DT.95272156  DT.417863  DT.100894881  DT.95293337  DT.92463978  DT.97804318  DT.203533 
    DT.70105280  DT.95143585  DT.75162779  DT.121251441  DT.121251425  DT.121251442  DT.92463965  DT.95272170 

    24/765 AceView cDNA sequences (see all 765):

    AW005366 AI362593 BP379139 CA416009 AI088767 BQ052859 BQ893339 BE857278 
    AW301158 BM744747 BQ017028 AA262347 AU118181 AA262766 BQ053145 AW468219 
    AI128389 AI814237 AV660610 BQ921110 AU117520 BP366574 BQ888921 H65028 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KLF6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                    -                                         -                                 
    SP2:                                                                                                
    SP3:                    -                             -     -     -                                 
    SP4:                    -                                   -     -                                 
    SP5:                                                  -     -     -                                 


    ECgene alternative splicing isoforms for KLF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLF6 expression in normal human tissues (normalized intensities)      KLF6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGAGCTGT
    KLF6 Expression
    About this image


    KLF6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Renal Collecting Duct System
             kidney ; cells in tubules   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Pancreas (Endocrine System)    fully expand to see all 3 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
             pancreas ; exocrine glandular cells   

    See KLF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLF6

    SOURCE GeneReport for Unigene cluster: Hs.4055

    UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
    Tissue specificity: Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and
    colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain,
    spleen and thymus

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLF6 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf61 , 5 Kruppel-like factor 61, 5 87.75(n)1
    95.05(a)1
      13 (2.94 cM)5
    238491  NM_011803.21  NP_035933.21 
     58614895 
    chicken
    (Gallus gallus)
    Aves KLF61 Kruppel-like factor 6 80.76(n)
    89.61(a)
      420463  NM_001030969.1  NP_001026140.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLF66
    Uncharacterized protein
    84(a)
    1 ↔ 1
    6(9648830-9662243)
    African clawed frog
    (Xenopus laevis)
    Amphibia copeb-prov2 core promoter element binding protein 79.83(n)    BC044713.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.203392 Danio rerio mRNA similar to core promoter element binding more 81.02(n)    BC048893.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta luna6
    luna
    21(a)
    1 → many
    2R(6865461-6994321)


    ENSEMBL Gene Tree for KLF6 (if available)
    TreeFam Gene Tree for KLF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLF6 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  SP52  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    18/33 SIMAP similar genes for KLF6 using alignment to 2 protein entries:     KLF6_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    WT1    KLF3    KLF1    SP6    KLF5
    KLF8    KLF4    ZFP64    KLF16    SP3    KLF7
    A-328A3.4    KLF12    SP5    ZNF78L1    KLF13    kr-znf3

    KLF6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/327 SNPs in KLF6 are shown (see all 327)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0651374
    ----see VAR_0651372 S P mis40--------
    VAR_0651364
    ----see VAR_0651362 W R mis40--------
    VAR_0651414
    ----see VAR_0651412 P T mis40--------
    VAR_0651424
    ----see VAR_0651422 S L mis40--------
    VAR_0651384
    ----see VAR_0651382 A D mis40--------
    VAR_0651434
    ----see VAR_0651432 R K mis40--------
    VAR_0651404
    ----see VAR_0651402 L P mis40--------
    VAR_0651394
    ----see VAR_0651392 S R mis40--------
    rs1862509211,2
    --3739997(+) ACGCCC/GACGAA 4 -- ds50010--------
    rs2009766921,2
    --3740127(+) ATCTT-/AACA  
            
    AACAT
    4 -- ds50010--------

    HapMap Linkage Disequilibrium report for KLF6 (3818188 - 3827473 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KLF6: --

    Human Gene Mutation Database (HGMD): KLF6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF6
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602053   
    OMIM disorders: 176807  137215  
    UniProtKB/Swiss-Prot: KLF6_HUMAN, Q99612
  • Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the
    esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It
    also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to
    adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types
    are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated
    infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually
    exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in
    sporadic disease. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate
    cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of
    prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma,
    prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid
    cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 20/51 diseases for KLF6 (see all 51):    About MalaCards
    prostate cancer, progression and metastasis of    transient global amnesia    prostate cancer, somatic    prostate cancer, progression of
    gastric cancer, somatic    hereditary diffuse gastric cancer    diffuse gastric cancer    oligodendroglioma
    neuroendocrine carcinoma    glioblastoma    stomach cancer    nasopharyngitis
    fatty liver disease    gastric cancer    hepatocellular carcinoma    lung adenocarcinoma
    prostate cancer    prostatitis    transitional cell carcinoma    familial adenomatous polyposis

    1 disease from the University of Copenhagen DISEASES database for KLF6:
    Prostate cancer

    KLF6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/29 Novoseek inferred disease relationships for KLF6 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    somatic mutations 63.5 25 19101139 (2), 17347589 (2), 17514651 (2), 15824733 (1) (see all 12)
    allelic loss 55.7 11 15824733 (1), 16872311 (1), 16230382 (1), 16856969 (1) (see all 7)
    prostate cancer 55.2 60 12651626 (6), 18755691 (4), 15247715 (4), 11752579 (3) (see all 21)
    hepatocellular carcinoma 45.5 26 16494780 (4), 15598377 (3), 16872311 (2), 18822210 (2) (see all 12)
    tumors 41.2 118 11752579 (4), 17514651 (4), 16702959 (4), 19097929 (3) (see all 46)
    allelic imbalance 37.1 6 15057748 (2), 17514651 (1)
    adenocarcinoma lung 37.1 1 17223258 (1)
    glioblastoma multiforme 35.6 1 12740910 (1)
    cancer 32.9 55 17143513 (5), 19097929 (4), 19333010 (2), 18174288 (2) (see all 26)
    colorectal cancer 31.2 19 16856969 (3), 17347589 (2), 16610031 (2), 15057748 (2) (see all 7)

    Genetic Association Database (GAD): KLF6
    Human Genome Epidemiology (HuGE) Navigator: KLF6 (13 documents)

    Export disorders for KLF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLF6 gene, integrated from 9 sources (see all 224):
    (articles sorted by number of sources associating them with KLF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter. (PubMed id 9685731)1, 2, 3 Suzuki T....Horikoshi M. (1998)
    2. The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease. (PubMed id 18515091)1, 4, 9 Miele L....Reeves H.L. (2008)
    3. KLF6, a candidate tumor suppressor gene mutated in prostate cancer. (PubMed id 11752579)1, 2, 9 Narla G....Friedman S.L. (2001)
    4. KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations. (PubMed id 19020536)1, 4, 9 Agell L....Lloreta J. (2008)
    5. Genetic alterations of the KLF6 gene in gastric cancer. (PubMed id 15824733)1, 2, 9 Cho Y.G....Park W.S. (2005)
    6. Genome-wide single nucleotide polymorphism analysis of lung cancer risk detects the KLF6 gene. (PubMed id 17223258)1, 4, 9 Spinola M....Dragani T.A. (2007)
    7. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. (PubMed id 15735005)1, 4, 9 Narla G....Martignetti J.A. (2005)
    8. Mutation screening and association study of the candidate prostate cancer susceptibility genes MSR1, PTEN, and KLF6. (PubMed id 16598737)1, 4, 9 Bar-Shira A....Orr-Urtreger A. (2006)
    9. A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. (PubMed id 9083102)1, 2, 9 Koritschoner N.P.... Patrito L.C. (1997)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1316 HGNC: 2235 AceView: COPEB Ensembl:ENSG00000067082 euGenes: HUgn1316
    ECgene: KLF6 H-InvDB: KLF6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLF6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLF6 gene:
    Search GeneIP for patents involving KLF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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