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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLF5 Gene

protein-coding   GIFtS: 66
GCID: GC13P073629

Kruppel-Like Factor 5 (Intestinal)


(Previous symbol: BTEB2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kruppel-Like Factor 5 (Intestinal)1 2     BTE-Binding Protein 22 3
BTEB21 2 3     GC-Box-Binding Protein 22 3
Basic Transcription Element-Binding Protein 22 3     Basic Transcription Element Binding Protein 22
Colon Krueppel-Like Factor2 3     Colon Kruppel-Like Factor2
Intestinal-Enriched Krueppel-Like Factor2 3     GC Box Binding Protein 22
Transcription Factor BTEB22 3     Intestinal-Enriched Kruppel-Like Factor2
CKLF2 3     Krueppel-Like Factor 52
IKLF2 3     

External Ids:    HGNC: 63491   Entrez Gene: 6882   Ensembl: ENSG000001025547   OMIM: 6029035   UniProtKB: Q138873   

Export aliases for KLF5 gene to outside databases

Previous GC identifers: GC13P071600 GC13P067627 GC13P072569 GC13P071430 GC13P072530 GC13P054330


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLF5 Gene:
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein
localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a
transcription factor. (provided by RefSeq, Jul 2008)

GeneCards Summary for KLF5 Gene: 
KLF5 (Kruppel-like factor 5 (intestinal)) is a protein-coding gene. Diseases associated with KLF5 include essential thrombocythemia, and cerebral aneurysms, and among its related super-pathways are Axon guidance. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
Function: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes

summary for KLF5 Gene:
The Kruppel-like factor family of zinc finger proteins act as transcription factors. KLF5 has been linked to
the maintenance of embryonic stem cell (ESC) pluripotency, as well as the regulation of cell proliferation
in the intestinal epithelium.

Gene Wiki entry for KLF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLF5 gene promoter:
         C/EBPbeta   p53   E2F-2   NF-kappaB   C/EBPalpha   CREB   E2F   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22.1   Ensembl cytogenetic band:  13q22.1   HGNC cytogenetic band: 13q21.3

KLF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF5 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P073629:  view genomic region     (about GC identifiers)

Start:
73,629,114 bp from pter      End:
73,651,676 bp from pter
Size:
22,563 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887 (See protein sequence)
Recommended Name: Krueppel-like factor 5  
Size: 457 amino acids; 50792 Da
Subunit: Interacts with WWP1
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for KLF5:
2EBT (3D)    
Secondary accessions: L0R3U5 L0R4T9 Q9UHP8
Alternative splicing: 3 isoforms:  Q13887-1   Q13887-2   Q13887-3   

Explore the universe of human proteins at neXtProt for KLF5: NX_Q13887

Explore proteomics data for KLF5 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13887

  • KLF5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLF5 Protein Expression
    REFSEQ proteins: NP_001721.2  
    ENSEMBL proteins: 
     ENSP00000366915   ENSP00000440407  
    Reactome Protein details: Q13887
    Human Recombinant Protein Products for KLF5: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLF5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    KLF5 for ontologies           About GeneDecksing



    KLF5 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q13887

    ProtoNet protein and cluster: Q13887

    UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    KLF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF5_HUMAN, Q13887
    Function: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI17320083
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    KLF5 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Klf5):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  mortality/aging  muscle 
     normal  respiratory system 

    KLF5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KLF5: Klf5tm1Yfk Klf5tm1.1Jwel Klf5tm1Rng

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLF5 
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    miRNA
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    miRTarBase miRNAs that target KLF5:
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLF5
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF5 (see all 35):
    hsa-miR-3938 hsa-miR-300 hsa-miR-16-1* hsa-miR-374a* hsa-miR-9 hsa-miR-3613-3p hsa-miR-3622a-5p hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF5 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLF5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Developmental Biology0.69
    2Transcriptional Regulation of White Adipocyte Differentiation
    Transcriptional Regulation of White Adipocyte Differentiation
    3Adipogenesis
    Adipogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KLF5
        Adipogenesis


    2        Reactome Pathways for KLF5
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation



    KLF5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for KLF5 (Q138872, 3 ENSP000003669154) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    ENSG00000235068Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS8479902
    GO:0030033microvillus assembly IEA--
    GO:0035914skeletal muscle cell differentiation IEA--

    KLF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLF5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KLF5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    StauprimideInhibits NME2 nuclear translocation; primes ESCs for differentiation[154589-96-5]
    UNC 926 hydrochlorideL3MBTL1 domain inhibitor[1184136-10-4]
    GANT 61GLI antagonist; inhibits Hedgehog (Hh) signaling[500579-04-4]
    KL 001Cryptochrome protein stabilizer; lengthens circadian period[309928-48-1]
    BI 6015Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist[93987-29-2]

    6 Novoseek inferred chemical compound relationships for KLF5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 53.9 16 8479902 (2), 9443972 (1), 15668237 (1), 16102754 (1) (see all 11)
    proline 4.56 3 9089417 (2), 8479902 (1)
    alanine 0 1 8479902 (1)
    estrogen 0 5 19569049 (5)
    serine 0 1 8479902 (1)
    cysteine 0 2 15735697 (1), 16223724 (1)

    Search CenterWatch for drugs/clinical trials and news about KLF5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLF5 gene: 
    NM_001730.3  

    Unigene Cluster for KLF5:

    Kruppel-like factor 5 (intestinal)
    Hs.508234  [show with all ESTs]
    Unigene Representative Sequence: AF132818
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477333 ENST00000377687(uc001vjd.3 uc001vje.3) ENST00000476859
    ENST00000464404 ENST00000539231
    miRNA
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    hsa-miR-3938 hsa-miR-300 hsa-miR-16-1* hsa-miR-374a* hsa-miR-9 hsa-miR-3613-3p hsa-miR-3622a-5p hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF5 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB030824.1 AF132818.1 AF287272.1 AK131397.1 AK296900.1 AK302280.1 AK304284.1 BC007695.1 
    BC014302.2 BC042131.1 BT006641.1 D14520.1 EF208215.1 HF546203.1 HF546204.1 

    8 DOTS entries:

    DT.446256  DT.91838856  DT.91766778  DT.91766782  DT.100794009  DT.95238739  DT.95238736  DT.40244648 

    24/230 AceView cDNA sequences (see all 230):

    CB114638 BU543015 BM981027 BX482248 AA315699 BQ446985 BU543512 BM263160 
    BX099498 AW262708 BC014302 BU676018 AW594272 W60597 BC042131 AI214469 
    AI358276 AI625497 AI955523 AA548839 AI758747 BU190597 AB030824 AW439676 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KLF5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -                       -               
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for KLF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLF5 expression in normal human tissues (normalized intensities)      KLF5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGCAGAA
    KLF5 Expression
    About this image


    KLF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 5 entries
             Zygote Zygote
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 5 entries
             Zygote Zygote
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 5 entries
             Zygote Zygote
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System

    See KLF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLF5

    SOURCE GeneReport for Unigene cluster: Hs.508234

    UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
    Tissue specificity: Expressed only in testis and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including KLF5: 
              WNT Signaling Targets in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLF5 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf51 , 5 Kruppel-like factor 51, 5 90.05(n)1
    92.31(a)1
      14 (49.43 cM)5
    122241  NM_009769.41  NP_033899.21 
     992986915 
    chicken
    (Gallus gallus)
    Aves KLF51 Kruppel-like factor 5 (intestinal) 80.27(n)
    85.64(a)
      418818  XM_417013.3  XP_417013.3 
    lizard
    (Anolis carolinensis)
    Reptilia KLF56
    Uncharacterized protein
    77(a)
    1 ↔ 1
    3(88396564-88432768)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146482 Xenopus laevis transcribed sequence with weak similarity more 76.67(n)    CD303121.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000060431 Kruppel-like factor 5-like 60.3(n)
    59.9(a)
      100006043  XM_001344880.4  XP_001344916.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98953 transcription factor 80(a)
    (best of 2)
      59C1   --


    ENSEMBL Gene Tree for KLF5 (if available)
    TreeFam Gene Tree for KLF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLF5 gene
    KLF12  SP82  KLF172  KLF142  SP62  KLF152  KLF22  KLF72  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    18/27 SIMAP similar genes for KLF5 using alignment to 3 protein entries:     KLF5_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    KLF7    KLF6    KLF4    DKFZp686O1631    KLF1
    ZNF78L1    A-328A3.4    DKFZp434J0650    DKFZp547H249    kr-znf3    smap-7
    ZFS-2    ZFS-5    ZNF468    ZNF    ZNF702P    ZFS-6

    KLF5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/436 SNPs in KLF5 are shown (see all 436)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355554
    A colorectal cancer sample4--see VAR_0355552 P S mis40--------
    rs1905120861,2
    --73631187(+) TTAGGC/TTGAAA 1 -- us2k10--------
    rs1813823411,2
    --73631268(+) TACAGC/TTACCG 1 -- us2k10--------
    rs1858188301,2
    C--73631278(+) GAATGC/TATTAA 1 -- us2k10--------
    rs1921136721,2
    --73631307(+) TTAAAA/GTTACA 1 -- us2k10--------
    rs580904851,2
    C--73631519(+) TGAAG-/ATGGAC 1 -- us2k10--------
    rs1839592311,2
    --73631519(+) TGAAGA/TTGGAC 1 -- us2k10--------
    rs1877190691,2
    --73631581(+) ATACTG/TTGATA 1 -- us2k10--------
    rs1909070451,2
    --73631735(+) TTATGG/TGCATA 1 -- us2k10--------
    rs1478742461,2
    --73631838(+) GTTTTA/TCTCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLF5 (73629114 - 73651676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLF5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv274461CNV Insertion20981092
    esv22464CNV Loss19812545
    nsv521789CNV Loss19592680
    nsv820122CNV Gain19587683


    Human Gene Mutation Database (HGMD): KLF5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF5
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602903    OMIM disorders: --

    20/33 diseases for KLF5 (see all 33):    About MalaCards
    essential thrombocythemia    cerebral aneurysms    gastrointestinal stromal tumor    arteriosclerosis
    azoospermia    esophageal cancer    choroiditis    colon cancer
    nasopharyngitis    myelodysplastic syndromes    acute lymphoblastic leukemia    acute myeloid leukemia
    lymphoblastic leukemia    prostate cancer    hypoxia    osteoarthritis
    esophagitis    myeloid leukemia    pancreatic cancer    schizophrenia


    KLF5 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for KLF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 30.2 7 19671674 (2), 14726538 (1), 15581624 (1)
    cancer 28.6 23 15735697 (2), 19448973 (2), 20388706 (2), 19411256 (1) (see all 18)
    tumors 25.1 43 14726538 (5), 18054006 (4), 16904982 (2), 17164780 (2) (see all 19)
    restenosis 24.5 2 11076828 (1), 20086047 (1)
    breast cancer 16.1 27 12242654 (6), 19668233 (5), 16638850 (4), 19569049 (3) (see all 7)
    bladder cancer 2.83 5 12901861 (4), 16184550 (1)
    atherosclerosis 2.49 1 20086047 (1)
    prostate cancer 2.14 14 12661032 (5), 18774944 (3), 19460858 (2)
    metastasis 0 2 16357509 (1), 17622557 (1)

    Genetic Association Database (GAD): KLF5
    Human Genome Epidemiology (HuGE) Navigator: KLF5 (6 documents)

    Export disorders for KLF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLF5 gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with KLF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. (PubMed id 8479902)1, 2, 3, 9 Sogawa K....Fujii-Kuriyama Y. (1993)
    2. Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter. (PubMed id 10572182)1, 2, 9 Shi H.... Teng C.T. (1999)
    3. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. (PubMed id 15735697)1, 2, 9 Chen C....Dong J.T. (2005)
    4. Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia. (PubMed id 18226501)1, 4, 9 Yanagi M....Shirakawa O. (2008)
    5. Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated wit h human hypertension. (PubMed id 20086047)1, 4, 9 Oishi Y....Nagai R. (2010)
    6. A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells. (PubMed id 9973612)1, 3, 9 Conkright M.D....Lingrel J.B. (1999)
    7. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PubMed id 17688680)1, 4, 9 Gutierrez-Aguilar R....Neve B. (2007)
    8. Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PubMed id 23134681)1, 2 Camacho-Vanegas O.... Martignetti J.A. (2013)
    9. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. (PubMed id 20101243)1, 4 Petersen G.M....Chanock S.J. (2010)
    10. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 688 HGNC: 6349 AceView: KLF5 Ensembl:ENSG00000102554 euGenes: HUgn688
    ECgene: KLF5 H-InvDB: KLF5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLF5 gene:
    Search GeneIP for patents involving KLF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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