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Aliases for KLF5 Gene

Aliases for KLF5 Gene

  • Kruppel Like Factor 5 2 3 5
  • Intestinal-Enriched Krueppel-Like Factor 3 4
  • Kruppel-Like Factor 5 (Intestinal) 2 3
  • (Intestinal Kruppel-Like Factor 2 3
  • Colon Krueppel-Like Factor 3 4
  • Transcription Factor BTEB2 3 4
  • BTE-Binding Protein 2 3 4
  • BTEB2 3 4
  • CKLF 3 4
  • IKLF 3 4
  • Basic Transcription Element Binding Protein 2 3
  • Basic Transcription Element-Binding Protein 2 4
  • Intestinal-Enriched Kruppel-Like Factor 3
  • Colon Kruppel-Like Factor 3
  • GC Box Binding Protein 2 3
  • GC-Box-Binding Protein 2 4
  • Krueppel-Like Factor 5 3
  • Klf5C Isoform 3

External Ids for KLF5 Gene

Previous HGNC Symbols for KLF5 Gene

  • BTEB2

Previous GeneCards Identifiers for KLF5 Gene

  • GC13P071600
  • GC13P067627
  • GC13P072569
  • GC13P071430
  • GC13P072530
  • GC13P073629
  • GC13P054330

Summaries for KLF5 Gene

Entrez Gene Summary for KLF5 Gene

  • This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for KLF5 Gene

KLF5 (Kruppel Like Factor 5) is a Protein Coding gene. Diseases associated with KLF5 include Colorectal Cancer. Among its related pathways are Adipogenesis and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is KLF4.

UniProtKB/Swiss-Prot for KLF5 Gene

  • Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Tocris Summary for KLF5 Gene

Gene Wiki entry for KLF5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF5 Gene

Genomics for KLF5 Gene

Regulatory Elements for KLF5 Gene

Enhancers for KLF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KLF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF5 Gene

Chromosome:
13
Start:
73,054,976 bp from pter
End:
73,077,542 bp from pter
Size:
22,567 bases
Orientation:
Plus strand

Genomic View for KLF5 Gene

Genes around KLF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF5 Gene

Proteins for KLF5 Gene

  • Protein details for KLF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13887-KLF5_HUMAN
    Recommended name:
    Krueppel-like factor 5
    Protein Accession:
    Q13887
    Secondary Accessions:
    • A2TJX0
    • L0R3U5
    • L0R4T9
    • Q9UHP8

    Protein attributes for KLF5 Gene

    Size:
    457 amino acids
    Molecular mass:
    50792 Da
    Quaternary structure:
    • Interacts with WWP1.

    Three dimensional structures from OCA and Proteopedia for KLF5 Gene

    Alternative splice isoforms for KLF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF5 Gene

Post-translational modifications for KLF5 Gene

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF5 Gene

Domains & Families for KLF5 Gene

Gene Families for KLF5 Gene

Protein Domains for KLF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q13887

UniProtKB/Swiss-Prot:

KLF5_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF5: view

Function for KLF5 Gene

Molecular function for KLF5 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Gene Ontology (GO) - Molecular Function for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16595680
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 16595680
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 17320083
genes like me logo Genes that share ontologies with KLF5: view
genes like me logo Genes that share phenotypes with KLF5: view

Animal Models for KLF5 Gene

MGI Knock Outs for KLF5:

Animal Model Products

CRISPR Products

Targeted motifs for KLF5 Gene
HOMER Transcription Factor Regulatory Elements motif KLF5
  • Consensus sequence: DGGGYGKGGC Submotif: canonical Cell Type: LoVo GEO ID: GSE49402

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KLF5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF5 Gene

Localization for KLF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF5 Gene COMPARTMENTS Subcellular localization image for KLF5 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with KLF5: view

Pathways & Interactions for KLF5 Gene

genes like me logo Genes that share pathways with KLF5: view

Pathways by source for KLF5 Gene

SIGNOR curated interactions for KLF5 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8479902
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with KLF5: view

Drugs & Compounds for KLF5 Gene

(9) Drugs for KLF5 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Verteporfin Approved, Investigational Pharma YAP inhibitor; disrupts YAP-TEAD interactions 86
BI 6015 Pharma HNF4α antagonist, Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist 0
GANT61 Pharma GLI antagonist, GLI antagonist; inhibits Hedgehog (Hh) signaling 0

(2) Additional Compounds for KLF5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
666-15
1433286-70-4
SIS3
521984-48-5

(5) Tocris Compounds for KLF5 Gene

Compound Action Cas Number
666-15 Potent and selective CREB inhibitor 1433286-70-4
BI 6015 Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist 93987-29-2
GANT 61 GLI antagonist; inhibits Hedgehog (Hh) signaling 500579-04-4
SIS3 Selective Smad3 inhibitor; inhibits TGF-betaR1 signaling 521984-48-5
Verteporfin YAP inhibitor; disrupts YAP-TEAD interactions 129497-78-5
genes like me logo Genes that share compounds with KLF5: view

Transcripts for KLF5 Gene

Unigene Clusters for KLF5 Gene

Kruppel-like factor 5 (intestinal):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KLF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:

Relevant External Links for KLF5 Gene

GeneLoc Exon Structure for
KLF5
ECgene alternative splicing isoforms for
KLF5

Expression for KLF5 Gene

mRNA expression in normal human tissues for KLF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF5 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.2), Skin - Sun Exposed (Lower leg) (x6.9), Skin - Not Sun Exposed (Suprapubic) (x6.6), and Colon - Transverse (x4.9).

Protein differential expression in normal tissues from HIPED for KLF5 Gene

This gene is overexpressed in Placenta (40.9) and Prostate (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLF5 Gene



Protein tissue co-expression partners for KLF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLF5 Gene:

KLF5

SOURCE GeneReport for Unigene cluster for KLF5 Gene:

Hs.508234

mRNA Expression by UniProt/SwissProt for KLF5 Gene:

Q13887-KLF5_HUMAN
Tissue specificity: Expressed only in testis and placenta.
genes like me logo Genes that share expression patterns with KLF5: view

Primer Products

Orthologs for KLF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF5 34
  • 93.54 (n)
  • 95.15 (a)
KLF5 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF5 34
  • 94.53 (n)
  • 95.62 (a)
KLF5 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf5 34
  • 89.82 (n)
  • 91.63 (a)
Klf5 16
Klf5 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLF5 34
  • 99.64 (n)
  • 99.34 (a)
KLF5 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf5 34
  • 90.05 (n)
  • 92.99 (a)
oppossum
(Monodelphis domestica)
Mammalia KLF5 35
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF5 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF5 34
  • 82.21 (n)
  • 89.22 (a)
KLF5 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF5 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf5 34
  • 72.65 (n)
  • 76.08 (a)
Str.15084 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14648 34
zebrafish
(Danio rerio)
Actinopterygii LOC100006043 34
  • 60.62 (n)
  • 59.8 (a)
klf5a 35
  • 46 (a)
OneToMany
klf5b 35
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12029 36
  • 79 (a)
CG9895 36
  • 80 (a)
dar1 35
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 36
  • 65 (a)
F56F11.3 36
  • 77 (a)
mua-1 36
  • 39 (a)
klf-1 35
  • 19 (a)
OneToMany
klf-2 35
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToOne
Species where no ortholog for KLF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF5 Gene

ENSEMBL:
Gene Tree for KLF5 (if available)
TreeFam:
Gene Tree for KLF5 (if available)

Paralogs for KLF5 Gene

Paralogs for KLF5 Gene

genes like me logo Genes that share paralogs with KLF5: view

Variants for KLF5 Gene

Sequence variations from dbSNP and Humsavar for KLF5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_035555 A colorectal cancer sample
rs1051343 -- 73,075,931(+) CTCAA(A/G)TGACA utr-variant-3-prime
rs1109940 -- 73,078,020(+) ATGCA(C/T)GAGAC downstream-variant-500B
rs1109941 -- 73,077,998(+) CGAAT(A/G)CTTAT downstream-variant-500B
rs1803204 -- 73,075,795(+) GCACA(A/C)AGGCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KLF5 Gene

Variant ID Type Subtype PubMed ID
dgv998n106 CNV deletion 24896259
esv22464 CNV loss 19812545
esv3310189 CNV mobile element insertion 20981092
esv3336418 CNV insertion 20981092
nsv1070180 CNV deletion 25765185
nsv521789 CNV loss 19592680
nsv820122 CNV gain 19587683

Variation tolerance for KLF5 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF5 Gene

Human Gene Mutation Database (HGMD)
KLF5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF5 Gene

Disorders for KLF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search KLF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF5

Genetic Association Database (GAD)
KLF5
Human Genome Epidemiology (HuGE) Navigator
KLF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF5
genes like me logo Genes that share disorders with KLF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF5 Gene

Publications for KLF5 Gene

  1. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. (PMID: 8479902) Sogawa K. … Fujii-Kuriyama Y. (Nucleic Acids Res. 1993) 2 3 4 22 65
  2. Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. (PMID: 20086047) Oishi Y. … Nagai R. (FASEB J. 2010) 3 22 46 65
  3. Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia. (PMID: 18226501) Yanagi M. … Shirakawa O. (Schizophr. Res. 2008) 3 22 46 65
  4. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PMID: 17688680) GutiAcrrez-Aguilar R. … Neve B. (BMC Med. Genet. 2007) 3 22 46 65
  5. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. (PMID: 15735697) Chen C. … Dong J.T. (Oncogene 2005) 3 4 22 65

Products for KLF5 Gene

Sources for KLF5 Gene

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