Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLF5 Gene

Aliases for KLF5 Gene

  • Kruppel Like Factor 5 2 3 5
  • Intestinal-Enriched Krueppel-Like Factor 3 4
  • Kruppel-Like Factor 5 (Intestinal) 2 3
  • (Intestinal Kruppel-Like Factor 2 3
  • Colon Krueppel-Like Factor 3 4
  • Transcription Factor BTEB2 3 4
  • BTE-Binding Protein 2 3 4
  • BTEB2 3 4
  • CKLF 3 4
  • IKLF 3 4
  • Basic Transcription Element Binding Protein 2 3
  • Basic Transcription Element-Binding Protein 2 4
  • Intestinal-Enriched Kruppel-Like Factor 3
  • Colon Kruppel-Like Factor 3
  • GC Box Binding Protein 2 3
  • GC-Box-Binding Protein 2 4
  • Krueppel-Like Factor 5 3
  • Klf5C Isoform 3

External Ids for KLF5 Gene

Previous HGNC Symbols for KLF5 Gene

  • BTEB2

Previous GeneCards Identifiers for KLF5 Gene

  • GC13P071600
  • GC13P067627
  • GC13P072569
  • GC13P071430
  • GC13P072530
  • GC13P073629
  • GC13P054330

Summaries for KLF5 Gene

Entrez Gene Summary for KLF5 Gene

  • This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GeneCards Summary for KLF5 Gene

KLF5 (Kruppel Like Factor 5) is a Protein Coding gene. Diseases associated with KLF5 include Colorectal Cancer. Among its related pathways are Mesodermal Commitment Pathway and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is KLF12.

UniProtKB/Swiss-Prot for KLF5 Gene

  • Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Tocris Summary for KLF5 Gene

Gene Wiki entry for KLF5 Gene

Additional gene information for KLF5 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF5 Gene

Genomics for KLF5 Gene

Regulatory Elements for KLF5 Gene

Enhancers for KLF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H073054 1.6 Ensembl ENCODE dbSUPER 7.7 +10.9 10949 23 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 DIS3 RNU4-10P BORA KLF5 FABP5P1
GH13H073464 1.3 Ensembl ENCODE dbSUPER 7.4 +411.0 411026 3 TBP LEF1 ARNT TAL1 JUN BACH1 RAD21 RFX5 FOSL1 TCF12 KLF5 GC13M073437 LOC105377816
GH13H073427 1.2 FANTOM5 ENCODE dbSUPER 5.6 +374.1 374116 3 STAT1 JUN CEBPB RAD21 EP300 FOXA1 JUND GATA3 STAT3 FOS KLF5 GC13P073437 MARK2P12
GH13H073597 0.6 ENCODE 11.1 +543.6 543576 1 JUN CEBPB EP300 FOSL1 JUND CTBP1 STAT3 CREB1 FOS KLF5 LOC105370256 LINC00393
GH13H073078 0.9 ENCODE dbSUPER 5.5 +25.5 25486 4 OSR2 JUND ZFHX2 ZNF366 POLR2A TRIM28 EGR2 ZNF18 KLF5 FABP5P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF5 Gene

Chromosome:
13
Start:
73,054,976 bp from pter
End:
73,077,542 bp from pter
Size:
22,567 bases
Orientation:
Plus strand

Genomic View for KLF5 Gene

Genes around KLF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF5 Gene

Proteins for KLF5 Gene

  • Protein details for KLF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13887-KLF5_HUMAN
    Recommended name:
    Krueppel-like factor 5
    Protein Accession:
    Q13887
    Secondary Accessions:
    • A2TJX0
    • L0R3U5
    • L0R4T9
    • Q9UHP8

    Protein attributes for KLF5 Gene

    Size:
    457 amino acids
    Molecular mass:
    50792 Da
    Quaternary structure:
    • Interacts with WWP1.

    Three dimensional structures from OCA and Proteopedia for KLF5 Gene

    Alternative splice isoforms for KLF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF5 Gene

Post-translational modifications for KLF5 Gene

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KLF5

No data available for DME Specific Peptides for KLF5 Gene

Domains & Families for KLF5 Gene

Gene Families for KLF5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q13887

UniProtKB/Swiss-Prot:

KLF5_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF5: view

Function for KLF5 Gene

Molecular function for KLF5 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Phenotypes From GWAS Catalog for KLF5 Gene

Gene Ontology (GO) - Molecular Function for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16595680
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 16595680
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with KLF5: view
genes like me logo Genes that share phenotypes with KLF5: view

Animal Models for KLF5 Gene

MGI Knock Outs for KLF5:

Animal Model Products

CRISPR Products

Targeted motifs for KLF5 Gene
HOMER Transcription Factor Regulatory Elements motif KLF5
  • Consensus sequence: DGGGYGKGGC Submotif: canonical Cell Type: LoVo GEO ID: GSE49402

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KLF5
  • Applied Biological Materials Clones for KLF5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF5 Gene

Localization for KLF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF5 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
plasma membrane 2
extracellular 2
cytosol 2
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Golgi apparatus (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with KLF5: view

Pathways & Interactions for KLF5 Gene

genes like me logo Genes that share pathways with KLF5: view

SIGNOR curated interactions for KLF5 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KLF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with KLF5: view

Drugs & Compounds for KLF5 Gene

(9) Drugs for KLF5 Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Verteporfin Approved, Investigational Pharma YAP inhibitor; disrupts YAP-TEAD interactions 90
BI 6015 Pharma HNF4α antagonist, Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist 0
GANT61 Pharma GLI antagonist, GLI antagonist; inhibits Hedgehog (Hh) signaling 0

(2) Additional Compounds for KLF5 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
666-15
1433286-70-4
SIS3
521984-48-5

(5) Tocris Compounds for KLF5 Gene

Compound Action Cas Number
666-15 Potent and selective CREB inhibitor 1433286-70-4
BI 6015 Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist 93987-29-2
GANT 61 GLI antagonist; inhibits Hedgehog (Hh) signaling 500579-04-4
SIS3 Selective Smad3 inhibitor; inhibits TGF-betaR1 signaling 521984-48-5
Verteporfin YAP inhibitor; disrupts YAP-TEAD interactions 129497-78-5
genes like me logo Genes that share compounds with KLF5: view

Transcripts for KLF5 Gene

Unigene Clusters for KLF5 Gene

Kruppel-like factor 5 (intestinal):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KLF5
  • Applied Biological Materials Clones for KLF5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KLF5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:

Relevant External Links for KLF5 Gene

GeneLoc Exon Structure for
KLF5
ECgene alternative splicing isoforms for
KLF5

Expression for KLF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF5 Gene

This gene is overexpressed in Esophagus - Mucosa (x9.2), Skin - Sun Exposed (Lower leg) (x6.9), Skin - Not Sun Exposed (Suprapubic) (x6.6), and Colon - Transverse (x4.9).

Protein differential expression in normal tissues from HIPED for KLF5 Gene

This gene is overexpressed in Placenta (40.9) and Prostate (28.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLF5 Gene



Protein tissue co-expression partners for KLF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLF5 Gene:

KLF5

SOURCE GeneReport for Unigene cluster for KLF5 Gene:

Hs.508234

mRNA Expression by UniProt/SwissProt for KLF5 Gene:

Q13887-KLF5_HUMAN
Tissue specificity: Expressed only in testis and placenta.

Evidence on tissue expression from TISSUES for KLF5 Gene

  • Nervous system(4.2)
  • Intestine(3.8)
  • Skin(2.6)
  • Muscle(2.4)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with KLF5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF5 Gene

Orthologs for KLF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF5 33 34
  • 99.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLF5 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF5 33 34
  • 94.53 (n)
cow
(Bos Taurus)
Mammalia KLF5 33 34
  • 93.54 (n)
rat
(Rattus norvegicus)
Mammalia Klf5 33
  • 90.05 (n)
mouse
(Mus musculus)
Mammalia Klf5 33 16 34
  • 89.82 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF5 34
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF5 33 34
  • 82.21 (n)
lizard
(Anolis carolinensis)
Reptilia KLF5 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf5 33
  • 72.65 (n)
Str.15084 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14648 33
zebrafish
(Danio rerio)
Actinopterygii LOC100006043 33
  • 60.62 (n)
klf5b 34
  • 51 (a)
OneToMany
klf5a 34
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9895 35
  • 80 (a)
CG12029 35
  • 79 (a)
dar1 34
  • 16 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56F11.3 35
  • 77 (a)
F53F8.1 35
  • 65 (a)
mua-1 35
  • 39 (a)
klf-2 34
  • 31 (a)
OneToMany
klf-1 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToOne
Species where no ortholog for KLF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF5 Gene

ENSEMBL:
Gene Tree for KLF5 (if available)
TreeFam:
Gene Tree for KLF5 (if available)

Paralogs for KLF5 Gene

Paralogs for KLF5 Gene

genes like me logo Genes that share paralogs with KLF5: view

Variants for KLF5 Gene

Sequence variations from dbSNP and Humsavar for KLF5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_035555 A colorectal cancer sample
rs1000064104 -- 73,060,708(+) AAATG(A/G)CTGTC intron-variant
rs1000091633 -- 73,053,760(+) GATTA(C/T)AGGCG upstream-variant-2KB
rs1000119501 -- 73,053,949(+) CGAGG(C/G)CCACC upstream-variant-2KB
rs1000125694 -- 73,064,393(+) GCAGT(-/GTTAAAATCAG)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF5 Gene

Variant ID Type Subtype PubMed ID
dgv998n106 CNV deletion 24896259
esv22464 CNV loss 19812545
esv3310189 CNV mobile element insertion 20981092
esv3336418 CNV insertion 20981092
nsv1070180 CNV deletion 25765185
nsv521789 CNV loss 19592680
nsv820122 CNV gain 19587683

Variation tolerance for KLF5 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF5 Gene

Human Gene Mutation Database (HGMD)
KLF5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF5 Gene

Disorders for KLF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search KLF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF5

Genetic Association Database (GAD)
KLF5
Human Genome Epidemiology (HuGE) Navigator
KLF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF5
genes like me logo Genes that share disorders with KLF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF5 Gene

Publications for KLF5 Gene

  1. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. (PMID: 8479902) Sogawa K … Fujii-Kuriyama Y (Nucleic acids research 1993) 2 3 4 22 60
  2. Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. (PMID: 20086047) Oishi Y … Nagai R (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010) 3 22 45 60
  3. Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia. (PMID: 18226501) Yanagi M … Shirakawa O (Schizophrenia research 2008) 3 22 45 60
  4. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PMID: 17688680) Gutiérrez-Aguilar R … Neve B (BMC medical genetics 2007) 3 22 45 60
  5. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. (PMID: 15735697) Chen C … Dong JT (Oncogene 2005) 3 4 22 60

Products for KLF5 Gene

  • Addgene plasmids for KLF5

Sources for KLF5 Gene

Content
Loading form....