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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLF5 Gene

protein-coding   GIFtS: 65
GCID: GC13P073629

Kruppel-like factor 5 (intestinal)


(Previous symbol: BTEB2)
 Explore 31 diseases affiliated with
KLF5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KLF5    

Aliases
for KLF5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kruppel-Like Factor 5 (Intestinal)1 2     BTE-Binding Protein 22 3
BTEB21 2 3     GC-Box-Binding Protein 22 3
CKLF1 2 3     Basic Transcription Element Binding Protein 22
IKLF1 2 3     Colon Kruppel-Like Factor2
Basic Transcription Element-Binding Protein 22 3     GC Box Binding Protein 22
Colon Krueppel-Like Factor2 3     Intestinal-Enriched Kruppel-Like Factor2
Intestinal-Enriched Krueppel-Like Factor2 3     Krueppel-Like Factor 52
Transcription Factor BTEB22 3     

External Ids:    HGNC: 63491   Entrez Gene: 6882   Ensembl: ENSG000001025547   OMIM: 6029035   UniProtKB: Q138873   

Export aliases for KLF5 gene to outside databases

Previous GC identifers: GC13P071600 GC13P067627 GC13P072569 GC13P071430 GC13P072530 GC13P054330


Summaries
for KLF5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KLF5:
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to
the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
Function: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes

summary for KLF5:
The Kruppel-like factor family of zinc finger proteins act as transcription factors. KLF5 has been linked to
the maintenance of embryonic stem cell (ESC) pluripotency, as well as the regulation of cell proliferation
in the intestinal epithelium.

Gene Wiki entry for KLF5


Genomic Views
for KLF5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLF5 gene promoter:
         C/EBPbeta   p53   E2F-2   NF-kappaB   C/EBPalpha   CREB   E2F   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22.1   Ensembl cytogenetic band:  13q22.1   HGNC cytogenetic band: 13q21.3

KLF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF5 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P073629:  view genomic region     (about GC identifiers)

Start:
 73,629,114 bp from pter      End:
 73,651,676 bp from pter
Size:
 22,563 bases      Orientation:
 plus strand

Proteins
for KLF5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887 (See protein sequence)
Recommended Name: Krueppel-like factor 5  
Size: 457 amino acids; 50792 Da
Subunit: Interacts with WWP1
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for KLF5:
2EBT (3D)    
Secondary accessions: Q9UHP8

Explore the universe of human proteins at neXtProt for KLF5: NX_Q13887

Post-translational modifications:

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13887

    • KLF5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001721.2  
    ENSEMBL proteins: 
     ENSP00000366915   ENSP00000440407  
    Reactome Protein details: Q13887
    Human Recombinant Protein Products: 
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    Novus Biologicals KLF5 Protein
    Novus Biologicals KLF5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KLF5

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    KLF5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for KLF5

    Protein Domains /
    Families
    for KLF5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KLF5 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q13887

    ProtoNet protein and cluster: Q13887

    UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Function
    for KLF5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
    Function: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLF5
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF5 (see all 35):
    hsa-miR-3938 hsa-miR-300 hsa-miR-16-1* hsa-miR-374a* hsa-miR-9 hsa-miR-3613-3p hsa-miR-3622a-5p hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KLF5 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for KLF5

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--


    KLF5 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for KLF5: Klf5tm1Yfk Klf5tm1.1Jwel Klf5tm1Rng
         12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Klf5):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  mortality/aging  muscle 
     normal  respiratory system 

    KLF5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KLF5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Expression of KLF5
    		Expression of KLF51.00
    2Transcriptional Regulation of White Adipocyte Differentiation
    		Transcriptional Regulation of White Adipocyte Differentiation1.00
    3Adipogenesis
    		Adipogenesis1.00
    4Axon guidance
    		Developmental Biology0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for KLF5 
        Adipogenesis

    3        Reactome Pathways for KLF5
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Expression of KLF5



    KLF5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/42 Interacting proteins for KLF5 (Q138872, 3 ENSP000003669154) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, 3, ENSP000003448184MINT-4652085 MINT-4652063 I2D: score=2 STRING: ENSP00000344818
    NFKB1P198383, ENSP000002265744I2D: score=3 STRING: ENSP00000226574
    RARAP102763, ENSP000002540664I2D: score=3 STRING: ENSP00000254066
    SETQ011053, ENSP000003617774I2D: score=3 STRING: ENSP00000361777
    GTF2F2P139843, ENSP000003408234I2D: score=2 STRING: ENSP00000340823
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS8479902
    GO:0008284positive regulation of cell proliferation ----
    GO:0030033microvillus assembly IEA--


    KLF5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KLF5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLF5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for KLF5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CID 5951923Kruppel-like factor 5 inhibitor[749872-43-3]
    6 Novoseek chemical compound relationships for KLF5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 53.9 16 8479902 (2), 9443972 (1), 15668237 (1), 16102754 (1) (see all 11)
    proline 4.56 3 9089417 (2), 8479902 (1)
    alanine 0 1 8479902 (1)
    estrogen 0 5 19569049 (5)
    serine 0 1 8479902 (1)
    cysteine 0 2 15735697 (1), 16223724 (1)

    Search CenterWatch for drugs/clinical trials and news about KLF5 

    Transcripts
    for KLF5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KLF5 gene: 
    NM_001730.3  

    Unigene Cluster for KLF5:

    Kruppel-like factor 5 (intestinal)
    Hs.508234  [show with all ESTs]
    Unigene Representative Sequence: AF132818
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477333 ENST00000377687(uc001vjd.3 uc001vje.3) ENST00000476859
    ENST00000464404 ENST00000539231

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLF5
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF5 (see all 35):
    hsa-miR-3938 hsa-miR-300 hsa-miR-16-1* hsa-miR-374a* hsa-miR-9 hsa-miR-3613-3p hsa-miR-3622a-5p hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmid: KLF5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF5 (see all 7)
    OriGene shRNA RFP: KLF5
    OriGene siRNA: KLF5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF5
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF5
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    Additional cDNA sequence: 

    AB030824.1 AF132818.1 AF287272.1 AK131397.1 AK296900.1 AK302280.1 AK304284.1 BC007695.1 
    BC014302.2 BC042131.1 BT006641.1 D14520.1 EF208215.1 HF546203.1 HF546204.1 

    8 DOTS entries:

    DT.446256  DT.91838856  DT.91766778  DT.91766782  DT.100794009  DT.95238739  DT.95238736  DT.40244648 

    24/230 AceView cDNA sequences (see all 230):

    BU676419 AI815057 BC042131 AA548839 BM981027 BU190597 AI358276 AW594272 
    BX099498 AI955523 BU543015 CB114638 AW389676 BM999080 BG778805 BM263160 
    BM845919 AB030824 AW439676 AA305544 BX482248 AI214469 AI758747 CB136407 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KLF5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -                       -               
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for KLF5

    Expression
    for KLF5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAAGCAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KLF5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Early Embryo (Zygote)ZygoteZygoteEarly Embryo
    Early Embryo (Zygote)Morula8-Cell EmbryoEarly Embryo
    Early Embryo (Zygote)MorulaMorula CellsEarly Embryo
    Early Embryo (Zygote)Zygote2-Cell EmbryoEarly Embryo
    Early Embryo (Zygote)Zygote4-Cell EmbryoEarly Embryo
    EndotheliumVeinsVascular Smooth Muscle CellsSmooth Muscle
    HeartAortic Arch ArteriesVascular Smooth Muscle CellsMyocardium, Neural Crest, Smooth Muscle
    HeartEndocardiumVascular Smooth Muscle CellsSmooth Muscle
    KidneyUreteric BudUreteric Bud CellsKidney
    KidneyUreteric BudKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Epiblast-like cells (Reconstitution of mo...)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See KLF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLF5

    SOURCE GeneReport for Unigene cluster: Hs.508234

    UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
    Tissue specificity: Expressed only in testis and placenta

        SABiosciences Expression via Pathway-Focused PCR Array including KLF5: 
              WNT Signaling Targets in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for KLF5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KLF5 gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KLF51 Kruppel-like factor 5 (intestinal) 80.27(n)
    85.64(a)    		   418818  XM_417013.3  XP_417013.3 
    lizard
    (Anolis carolinensis)    		 Reptilia KLF56
    --
    		 --
    		 75(a)
    10(a)
    		 1 ↔ 1
    possible ortholog
    		 3(88396608-88432345)
    3(88021848-88042132)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.146482 Xenopus laevis transcribed sequence with weak similarity more 76.67(n)    CD303121.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000060431 Kruppel-like factor 5-like 60.3(n)
    59.9(a)    		   100006043  XM_001344880.4  XP_001344916.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG98953 transcription factor 80(a)
    (best of 2)    		   59C1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F56F11.33 zinc finger protein 77(a)
    (best of 3)    		   III(2946712-2952243)   --


    ENSEMBL Gene Tree for KLF5 (if available)
    TreeFam Gene Tree for KLF5 (if available) 

    Paralogs
    for KLF5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLF5 gene
    KLF12  KLF112  KLF62  KLF102  KLF42  KLF142  KLF162  KLF22  
    KLF152  KLF122  KLF92  KLF32  KLF72  KLF132  KLF82  
    18/30 SIMAP similar genes for KLF5 using alignment to 5 protein entries:     KLF5_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    DKFZp313F0536    KLF7    KLF6    DKFZp686O1631    KLF1
    ZNF78L1    A-328A3.4    DKFZp434J0650    DKFZp547H249    kr-znf3    smap-7
    ZFS-2    ZFS-5    ZNF468    ZNF    ZNF702P    KLF4

    KLF5 for paralogs           About GeneDecksing



    Genomic Variants
    for KLF5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/373 NCBI SNPs in KLF5 are shown (see all 373)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1905120861,2
    		--73631187(+) TTAGGC/TTGAAA 1 -- us2k10--------
    rs1813823411,2
    		--73631268(+) TACAGC/TTACCG 1 -- us2k10--------
    rs1858188301,2
    		--73631278(+) GAATGC/TATTAA 1 -- us2k10--------
    rs1921136721,2
    		--73631307(+) TTAAAA/GTTACA 1 -- us2k10--------
    rs580904851,2
    		C,--73631519(+) TGAAG-/ATGGAC 1 -- us2k10--------
    rs1839592311,2
    		--73631519(+) TGAAGA/TTGGAC 1 -- us2k10--------
    rs1877190691,2
    		--73631581(+) ATACTG/TTGATA 1 -- us2k10--------
    rs1909070451,2
    		--73631735(+) TTATGG/TGCATA 1 -- us2k10--------
    rs1478742461,2
    		--73631838(+) GTTTTA/TCTCTG 1 -- us2k10--------
    rs38128521,2
    		C,F,H,--73631873(-) ACAGTT/CTTACA 1 -- us2k122Minor allele frequency- C:0.07NS EA NA WA 2760

    HapMap Linkage Disequilibrium report for KLF5 (73629114 - 73651676 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for KLF5
         2 CNVs: 58641 66480
    Human Gene Mutation Database (HGMD): KLF5

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF5
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    Disorders / Diseases
    for KLF5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KLF5 for disorders           About GeneDecksing

    OMIM gene information: 602903    OMIM disorders: --

    20/31 diseases for KLF5 (see all 31):    About MalaCards
    gastrointestinal stromal tumor    essential thrombocythemia    acute lymphoblastic leukemia    lymphoblastic leukemia
    acute myeloid leukemia    myeloid leukemia    arteriosclerosis    myelodysplastic syndrome
    rheumatoid arthritis    colon cancer    azoospermia    prostate cancer
    breast cancer    leukemia    colon carcinoma    esophageal cancer
    choroiditis    esophagitis    arthritis    gastric cancer

    9 Novoseek disease relationships for KLF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 30.2 7 19671674 (2), 14726538 (1), 15581624 (1)
    cancer 28.6 23 15735697 (2), 19448973 (2), 20388706 (2), 19411256 (1) (see all 18)
    tumors 25.1 43 14726538 (5), 18054006 (4), 16904982 (2), 17164780 (2) (see all 19)
    restenosis 24.5 2 11076828 (1), 20086047 (1)
    breast cancer 16.1 27 12242654 (6), 19668233 (5), 16638850 (4), 19569049 (3) (see all 7)
    bladder cancer 2.83 5 12901861 (4), 16184550 (1)
    atherosclerosis 2.49 1 20086047 (1)
    prostate cancer 2.14 14 12661032 (5), 18774944 (3), 19460858 (2)
    metastasis 0 2 16357509 (1), 17622557 (1)

    Genetic Association Database (GAD): KLF5
    Human Genome Epidemiology (HuGE) Navigator: KLF5 (6 documents)

    Export disorders for KLF5 gene to outside databases

    Publications
    for KLF5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLF5 gene, integrated from 9 sources (see all 141):
    (articles sorted by number of sources associating them with KLF5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. (PubMed id 8479902)1, 2, 3, 9 Sogawa K....Fujii-Kuriyama Y. (1993)
    2. Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter. (PubMed id 10572182)1, 2, 9 Shi H.... Teng C.T. (1999)
    3. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. (PubMed id 15735697)1, 2, 9 Chen C....Dong J.T. (2005)
    4. A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells. (PubMed id 9973612)1, 3, 9 Conkright M.D....Lingrel J.B. (1999)
    5. Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. (PubMed id 19411256)1, 9 Liu R....Chen C. (2009)
    8. Up-regulation of KrA1ppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor- 1alpha. (PubMed id 19671674)1, 9 Mori A....Stoeltzing O. (2009)
    9. Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer. (PubMed id 16638850)1, 9 Tong D....Zeillinger R. (2006)
    10. Acetylation of KLF5 alters the assembly of p15 transc ription factors in transforming growth factor-beta-mediated induction in epithe lial cells. (PubMed id 19419955)1, 9 Guo P....Dong J.T. (2009)

    External Searches for KLF5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing KLF5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 688 HGNC: 6349 AceView: KLF5 Ensembl:ENSG00000102554 euGenes: HUgn688
    ECgene: KLF5 H-InvDB: KLF5

    Other Databases showing KLF5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KLF5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF5 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KLF5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KLF5 gene:
    Search GeneIP for patents involving KLF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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