Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



KLF5 Gene

protein-coding   GIFtS: 65
GCID: GC13P073629

Kruppel-Like Factor 5 (Intestinal)


(Previous symbol: BTEB2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Kruppel-Like Factor 5 (Intestinal)1 2     Basic Transcription Element Binding Protein 22
BTEB21 2 3     Colon Kruppel-Like Factor2
Colon Krueppel-Like Factor2 3     GC Box Binding Protein 22
Intestinal-Enriched Krueppel-Like Factor2 3     Intestinal-Enriched Kruppel-Like Factor2
Transcription Factor BTEB22 3     Krueppel-Like Factor 52
CKLF2 3     Basic Transcription Element-Binding Protein 23
IKLF2 3     GC-Box-Binding Protein 23
BTE-Binding Protein 22 3     

External Ids:    HGNC: 63491   Entrez Gene: 6882   Ensembl: ENSG000001025547   OMIM: 6029035   UniProtKB: Q138873   

Export aliases for KLF5 gene to outside databases

Previous GC identifers: GC13P071600 GC13P067627 GC13P072569 GC13P071430 GC13P072530 GC13P054330


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for KLF5 Gene:
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a
transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes.
This protein acts downstream of multiple different signaling pathways and is regulated by post-translational
modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene
may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Nov 2013)

GeneCards Summary for KLF5 Gene:
KLF5 (Kruppel-like factor 5 (intestinal)) is a protein-coding gene. Diseases associated with KLF5 include cerebral aneurysms, and essential thrombocythemia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
Function: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes

summary for KLF5 Gene:
The Kruppel-like factor family of zinc finger proteins act as transcription factors. KLF5 has been linked to
the maintenance of embryonic stem cell (ESC) pluripotency, as well as the regulation of cell proliferation
in the intestinal epithelium.

Gene Wiki entry for KLF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF5 gene promoter:
         C/EBPbeta   p53   E2F-2   NF-kappaB   C/EBPalpha   CREB   E2F   deltaCREB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF5 promoter sequence
   Search Chromatin IP Primers for KLF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22.1   Ensembl cytogenetic band:  13q22.1   HGNC cytogenetic band: 13q21.3

KLF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF5 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P073629:  view genomic region     (about GC identifiers)

Start:
73,629,114 bp from pter      End:
73,651,676 bp from pter
Size:
22,563 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887 (See protein sequence)
Recommended Name: Krueppel-like factor 5  
Size: 457 amino acids; 50792 Da
Subunit: Interacts with WWP1
1 PDB 3D structure from and Proteopedia for KLF5:
2EBT (3D)    
Secondary accessions: L0R3U5 L0R4T9 Q9UHP8
Alternative splicing: 3 isoforms:  Q13887-1   Q13887-2   Q13887-3   

Explore the universe of human proteins at neXtProt for KLF5: NX_Q13887

Explore proteomics data for KLF5 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273747.1  NP_001721.2  

    ENSEMBL proteins: 
     ENSP00000366915   ENSP00000440407  
    Reactome Protein details: Q13887

    KLF5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for KLF5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for KLF5
    GenScript Custom Purified and Recombinant Proteins Services for KLF5
    Novus Biologicals KLF5 Protein
    Novus Biologicals KLF5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLF5

    KLF5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of KLF5
    R&D Systems Antibodies for KLF5
    OriGene Antibodies for KLF5
    OriGene Custom Antibody Services for KLF5
    Novus Biologicals KLF5 Antibodies
    Search for Antibodies for KLF5 at Abcam
    Cloud-Clone Corp. Antibodies for KLF5
    ThermoFisher Antibodies for KLF5
    LSBio Antibodies in human, mouse, rat for KLF5

    KLF5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for KLF5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for KLF5
    Cloud-Clone Corp. CLIAs for KLF5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q13887

    ProtoNet protein and cluster: Q13887

    UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    KLF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF5_HUMAN, Q13887
    Function: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI17320083
    GO:0046872metal ion binding IEA--
         
    KLF5 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Klf5):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  immune system  mortality/aging  muscle 
     normal  reproductive system  respiratory system  tumorigenesis 

    KLF5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KLF5: Klf5tm1Yfk Klf5tm1.1Jwel Klf5tm1Rng

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLF5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLF5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLF5

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  DGGGYGKGGC 

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLF5:
    hsa-mir-141-3p (MIRT001812), hsa-mir-128-3p (MIRT022040), hsa-mir-21-5p (MIRT030940), hsa-mir-9-5p (MIRT021472)

    Block miRNA regulation of human, mouse, rat KLF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF5 (see all 35):
    hsa-miR-3938 hsa-miR-300 hsa-miR-16-1* hsa-miR-374a* hsa-miR-9 hsa-miR-3613-3p hsa-miR-3622a-5p hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLF5
    Predesigned siRNA for gene silencing in human, mouse, rat KLF5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for KLF5

    Clone
    Products:
         
    OriGene clones in human, mouse for KLF5 (see all 6)
    OriGene ORF clones in mouse, rat for KLF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLF5 (NM_001730)
    Sino Biological Human cDNA Clone for KLF5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLF5
    Browse ESI BIO Cell Lines and PureStem Progenitors for KLF5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    KLF5_HUMAN, Q13887: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005886plasma membrane IDA--

    KLF5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for KLF5 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Developmental Biology0.63
    2Fatty acid, triacylglycerol, and ketone body metabolism
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    3Adipogenesis
    Adipogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for KLF5
        Adipogenesis


    1 Reactome Pathway for KLF5
        Transcriptional regulation of white adipocyte differentiation



    KLF5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including KLF5: 
              WNT Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KLF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KLF5 (Q138871, 2, 3 ENSP000003669154) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000230336Q018603, ENSP000004000474I2D: score=1 STRING: ENSP00000400047
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000237582Q018603, ENSP000003916814I2D: score=1 STRING: ENSP00000391681
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS8479902
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0030033microvillus assembly IEA--
    GO:0035914skeletal muscle cell differentiation IEA--

    KLF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for KLF5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    StauprimideInhibits NME2 nuclear translocation; primes ESCs for differentiation[154589-96-5]
    UNC 926 hydrochlorideL3MBTL1 domain inhibitor[1184136-10-4]
    GANT 61GLI antagonist; inhibits Hedgehog (Hh) signaling[500579-04-4]
    KL 001Cryptochrome protein stabilizer; lengthens circadian period[309928-48-1]
    BI 6015Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist[93987-29-2]

    6 Novoseek inferred chemical compound relationships for KLF5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 53.9 16 8479902 (2), 9443972 (1), 15668237 (1), 16102754 (1) (see all 11)
    proline 4.56 3 9089417 (2), 8479902 (1)
    alanine 0 1 8479902 (1)
    estrogen 0 5 19569049 (5)
    serine 0 1 8479902 (1)
    cysteine 0 2 15735697 (1), 16223724 (1)



    KLF5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for KLF5 gene (2 alternative transcripts): 
    NM_001286818.1  NM_001730.4  

    Unigene Cluster for KLF5:

    Kruppel-like factor 5 (intestinal)
    Hs.508234  [show with all ESTs]
    Unigene Representative Sequence: AF132818
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000477333 ENST00000377687(uc001vjd.3 uc001vje.3) ENST00000476859
    ENST00000464404 ENST00000539231
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF5 (see all 35):
    hsa-miR-3938 hsa-miR-300 hsa-miR-16-1* hsa-miR-374a* hsa-miR-9 hsa-miR-3613-3p hsa-miR-3622a-5p hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLF5
    Predesigned siRNA for gene silencing in human, mouse, rat KLF5
    Clone
    Products:
         
    OriGene clones in human, mouse for KLF5 (see all 6)
    OriGene ORF clones in mouse, rat for KLF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLF5 (NM_001730)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KLF5
    OriGene qSTAR qPCR primer pairs in human, mouse for KLF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF5
      QuantiTect SYBR Green Assays in human, mouse, rat KLF5
      QuantiFast Probe-based Assays in human, mouse, rat KLF5

    Additional mRNA sequence: 

    AB030824.1 AF132818.1 AF287272.1 AK131397.1 AK296900.1 AK302280.1 AK304284.1 BC007695.1 
    BC014302.2 BC042131.1 BT006641.1 D14520.1 EF208215.1 HF546203.1 HF546204.1 

    8 DOTS entries:

    DT.446256  DT.91838856  DT.91766778  DT.91766782  DT.100794009  DT.95238739  DT.95238736  DT.40244648 

    Selected AceView cDNA sequences (see all 230):

    BM845919 BM910650 CB136407 AI625497 AW594272 CK820216 AI214469 BX099498 
    AI358276 CB133153 AI815057 CB121615 AB030824 BM263160 AW389676 AA548839 
    BX482248 AW262708 BU676018 BU543015 BU676419 AI283975 BQ446985 CB114638 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KLF5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:        -                       -               
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for KLF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    KLF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGCAGAA
    KLF5 Expression
    About this image


    KLF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 5 entries
             Zygote Zygote
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 5 entries
             Zygote Zygote
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 5 entries
             Zygote Zygote
     
     Epithelial Cells
             Fetal Corneal Basal Epithelial Cells Corneal Epithelium
     
     Eye (Sensory Organs)    fully expand to see all 6 entries
             Fetal Corneal Basal Epithelial Cells Corneal Epithelium
    KLF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508234

    UniProtKB/Swiss-Prot: KLF5_HUMAN, Q13887
    Tissue specificity: Expressed only in testis and placenta

        Pathway & Disease-focused RT2 Profiler PCR Array including KLF5: 
              WNT Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KLF5
    OriGene qSTAR qPCR primer pairs in human, mouse for KLF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF5
    QuantiTect SYBR Green Assays in human, mouse, rat KLF5
    QuantiFast Probe-based Assays in human, mouse, rat KLF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for KLF5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf51 , 5 Kruppel-like factor 51, 5 89.82(n)1
    91.63(a)1
      14 (49.43 cM)5
    122241  NM_009769.41  NP_033899.21 
     992986915 
    chicken
    (Gallus gallus)
    Aves KLF51 Kruppel-like factor 5 (intestinal) 82.21(n)
    89.22(a)
      418818  XM_417013.4  XP_417013.4 
    lizard
    (Anolis carolinensis)
    Reptilia KLF56
    Kruppel-like factor 5 (intestinal)
    78(a)
    1 ↔ 1
    3(88396564-88432768)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146482 Xenopus laevis transcribed sequence with weak similarity more 76.67(n)    CD303121.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000060431 Kruppel-like factor 5-like 60.62(n)
    59.8(a)
      100006043  XM_001344880.5  XP_001344916.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98953 transcription factor 80(a)
    (best of 2)
      59C1   --
    worm
    (Caenorhabditis elegans)
    Secernentea F56F11.33 zinc finger protein 77(a)
    (best of 3)
      III(2946712-2952243)   --


    ENSEMBL Gene Tree for KLF5 (if available)
    TreeFam Gene Tree for KLF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for KLF5 gene
    KLF12  SP82  KLF172  KLF142  SP62  KLF152  KLF22  KLF72  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    Selected SIMAP similar genes for KLF5 using alignment to 3 protein entries:     KLF5_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    KLF7    KLF6    DKFZp686O1631    KLF1    KLF4
    ZNF78L1    A-328A3.4    DKFZp434J0650    DKFZp547H249    kr-znf3    smap-7
    ZFS-2    ZFS-5    ZNF468    ZNF    ZNF702P    ZFS-6

    KLF5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for KLF5 (see all 436)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355554
    A colorectal cancer sample4--see VAR_0355552 P S mis40--------
    rs1905120861,2
    --73631187(+) TTAGGC/TTGAAA 1 -- us2k10--------
    rs1813823411,2
    --73631268(+) TACAGC/TTACCG 1 -- us2k10--------
    rs1858188301,2
    C--73631278(+) GAATGC/TATTAA 1 -- us2k10--------
    rs1921136721,2
    --73631307(+) TTAAAA/GTTACA 1 -- us2k10--------
    rs580904851,2
    C--73631519(+) TGAAG-/ATGGAC 1 -- us2k10--------
    rs1839592311,2
    --73631519(+) TGAAGA/TTGGAC 1 -- us2k10--------
    rs1877190691,2
    --73631581(+) ATACTG/TTGATA 1 -- us2k10--------
    rs1909070451,2
    --73631735(+) TTATGG/TGCATA 1 -- us2k10--------
    rs1478742461,2
    --73631838(+) GTTTTA/TCTCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLF5 (73629114 - 73651676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KLF5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274461CNV Insertion20981092
    esv22464CNV Loss19812545
    nsv521789CNV Loss19592680
    nsv820122CNV Gain19587683

    Human Gene Mutation Database (HGMD): KLF5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF5
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602903    OMIM disorders: --

    Selected diseases for KLF5 (see all 32):    
    About MalaCards
    cerebral aneurysms    essential thrombocythemia    gastrointestinal stromal tumor    arteriosclerosis
    azoospermia    esophageal cancer    choroiditis    myelodysplastic syndromes
    acute myeloid leukemia    nasopharyngitis    atherosclerosis    osteoarthritis
    breast and colorectal cancer    lymphoblastic leukemia    cerebritis    prostate cancer
    myeloid leukemia    esophagitis    pancreatic cancer    hypoxia


    KLF5 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for KLF5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 30.2 7 19671674 (2), 14726538 (1), 15581624 (1)
    cancer 28.6 23 15735697 (2), 19448973 (2), 20388706 (2), 19411256 (1) (see all 18)
    tumors 25.1 43 14726538 (5), 18054006 (4), 16904982 (2), 17164780 (2) (see all 19)
    restenosis 24.5 2 11076828 (1), 20086047 (1)
    breast cancer 16.1 27 12242654 (6), 19668233 (5), 16638850 (4), 19569049 (3) (see all 7)
    bladder cancer 2.83 5 12901861 (4), 16184550 (1)
    atherosclerosis 2.49 1 20086047 (1)
    prostate cancer 2.14 14 12661032 (5), 18774944 (3), 19460858 (2)
    metastasis 0 2 16357509 (1), 17622557 (1)

    Genetic Association Database (GAD): KLF5
    Human Genome Epidemiology (HuGE) Navigator: KLF5 (6 documents)

    Export disorders for KLF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for KLF5 gene, integrated from 10 sources (see all 163):
    (articles sorted by number of sources associating them with KLF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. (PubMed id 8479902)1, 2, 3, 9 Sogawa K....Fujii-Kuriyama Y. (Nucleic Acids Res. 1993)
    2. Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter. (PubMed id 10572182)1, 2, 9 Shi H.... Teng C.T. (Nucleic Acids Res. 1999)
    3. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. (PubMed id 15735697)1, 2, 9 Chen C....Dong J.T. (Oncogene 2005)
    4. Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia. (PubMed id 18226501)1, 4, 9 Yanagi M....Shirakawa O. (Schizophr. Res. 2008)
    5. Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension. (PubMed id 20086047)1, 4, 9 Oishi Y....Nagai R. (FASEB J. 2010)
    6. A gene encoding an intestinal-enriched member of the KrA1ppel-like factor family expressed in intestinal epithelial cells. (PubMed id 9973612)1, 3, 9 Conkright M.D....Lingrel J.B. (Nucleic Acids Res. 1999)
    7. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PubMed id 17688680)1, 4, 9 GutiAcrrez-Aguilar R....Neve B. (BMC Med. Genet. 2007)
    8. Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PubMed id 23134681)1, 2 Camacho-Vanegas O.... Martignetti J.A. (FASEB J. 2013)
    9. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. (PubMed id 20101243)1, 4 Petersen G.M....Chanock S.J. (Nat. Genet. 2010)
    10. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 688 HGNC: 6349 AceView: KLF5 Ensembl:ENSG00000102554 euGenes: HUgn688
    ECgene: KLF5 H-InvDB: KLF5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for KLF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for KLF5 gene:
    Search GeneIP for patents involving KLF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of KLF5
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for KLF5 (KLF5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for KLF5   OriGene RNAi products in human, mouse, rat for KLF5  
     OriGene qPCR primer pairs and template standards for KLF5   OriGene Protein Over-expression Lysate for KLF5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for KLF5  
     OriGene qSTAR qPCR primer pairs in human, mouse for KLF5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for KLF5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLF5   OriGene Custom Protein Services for KLF5  

     
     
     Block miRNA regulation of human, mouse, rat KLF5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLF5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF5 Predesigned siRNA for gene silencing in human, mouse, rat KLF5
     QuantiFast Probe-based Assays in human, mouse, rat KLF5 QuantiTect SYBR Green Assays in human, mouse, rat KLF5
     PCR Arrays including human, mouse, rat KLF5 Search Chromatin IP Primers for KLF5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF5  GeneGlobe Interaction Network for KLF5
     Regulatory tfbs in KLF5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for KLF5 GenScript cDNA clones with any tag delivered in your preferred vector for KLF5
     GenScript Custom Assay Services for KLF5 GenScript Custom overexpressing Cell Line Services for KLF5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for KLF5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for KLF5
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     KLF5 antibodies
     KLF5 proteins
     KLF5 lysates
     Search for Antibodies for KLF5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KLF5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for KLF5
     Antibodies for KLF5
     ELISAs for KLF5
     CLIAs for KLF5



     Browse ESI BIO Cell Lines and PureStem Progenitors for KLF5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF5
     SwitchGear 3'UTR luciferase reporter plasmids for KLF5
     SwitchGear Promoter luciferase reporter plasmids for KLF5
     ThermoFisher Antibodies for KLF5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLF5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLF5
     LSBio Antibodies in human, mouse, rat for KLF5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      KLF5 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4