Aliases for KLF5 Gene
External Ids for KLF5 Gene
Previous HGNC Symbols for KLF5 Gene
Previous GeneCards Identifiers for KLF5 Gene
This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. The encoded protein is a transcriptional activator that binds directly to a specific recognition motif in the promoters of target genes. This protein acts downstream of multiple different signaling pathways and is regulated by post-translational modification. It may participate in both promoting and suppressing cell proliferation. Expression of this gene may be changed in a variety of different cancers and in cardiovascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
GeneCards Summary for KLF5 Gene
KLF5 (Kruppel Like Factor 5) is a Protein Coding gene. Diseases associated with KLF5 include Colorectal Cancer. Among its related pathways are Mesodermal Commitment Pathway and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is KLF12.
UniProtKB/Swiss-Prot for KLF5 Gene
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.