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KLF4 Gene

protein-coding   GIFtS: 67
GCID: GC09M110247

Kruppel-Like Factor 4 (Gut)

  See KLF4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kruppel-Like Factor 4 (Gut)1 2     Gut-Enriched Krueppel-Like Factor2 3
EZF2 3 5     Endothelial Kruppel-Like Zinc Finger Protein2
GKLF2 3 5     Krueppel-Like Factor 42
Epithelial Zinc Finger Protein EZF2 3     

External Ids:    HGNC: 63481   Entrez Gene: 93142   Ensembl: ENSG000001368267   OMIM: 6022535   UniProtKB: O434743   

Export aliases for KLF4 gene to outside databases

Previous GC identifers: GC09M101042 GC09M101979 GC09M103704 GC09M105626 GC09M107326 GC09M109286 GC09M079848


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLF4 Gene:
KLF4 (Kruppel-like factor 4 (gut)) is a protein-coding gene. Diseases associated with KLF4 include secretory meningioma, and skin squamous cell carcinoma. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF4_HUMAN, O43474
Function: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence.
Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of
key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem
cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and
for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial
cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53
transcription

Gene Wiki entry for KLF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF4 gene promoter:
         SRF   STAT1   AP-2alpha isoform 3   SRF (504 AA)   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KLF4 promoter sequence
   Search Chromatin IP Primers for KLF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31   Ensembl cytogenetic band:  9q31.2   HGNC cytogenetic band: 9q31

KLF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF4 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M110247:  view genomic region     (about GC identifiers)

Start:
110,247,133 bp from pter      End:
110,252,763 bp from pter
Size:
5,631 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLF4_HUMAN, O43474 (See protein sequence)
Recommended Name: Krueppel-like factor 4  
Size: 513 amino acids; 54671 Da
Subunit: Interacts with POU5F1/OCT4 and SOX2 (By similarity). Interacts with MUC1 (via the C-terminal domain).
Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a
Biotechnology: POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors
are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent
stem) cells. iPS cells exhibit the morphology and growth properties of ES cells and express ES cell marker genes
Sequence caution: Sequence=AAB48399.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAC03462.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAD42165.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH29923.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAH30811.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=ABG25917.1; Type=Erroneous gene model prediction;
Sequence=BAG36271.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW59020.1;
Type=Erroneous gene model prediction; Sequence=EAW59021.1; Type=Erroneous gene model prediction;
Secondary accessions: B2R8S4 B3KT79 L0R3I6 L0R4N5 P78338 Q5T3J8 Q5T3J9 Q8N717 Q9UNP3
Alternative splicing: 5 isoforms:  O43474-3   O43474-1   O43474-4   O43474-5   O43474-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLF4: NX_O43474

Explore proteomics data for KLF4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32
  • Modification sites at PhosphoSitePlus

  • See KLF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004226.3  
    ENSEMBL proteins: 
     ENSP00000363804   ENSP00000399921   ENSP00000404922  
    Reactome Protein details: O43474

    KLF4 Human Recombinant Protein Products:

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    antibodies-online proteins for KLF4 (10 products) 

     
    antibodies-online peptides for KLF4

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    antibodies-online kits for KLF4 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O43474

    ProtoNet protein and cluster: O43474

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: KLF4_HUMAN, O43474
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with KLF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF4_HUMAN, O43474
    Function: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence.
    Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of
    key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem
    cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and
    for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial
    cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53
    transcription

         Genatlas biochemistry entry for KLF4:
    Kruppel-like factor 4 (gut),zinc finger protein,mouse EZF and GKLF homolog,nuclear,expressed in select
    tissues,colon,testis,lung and small intestine,binding DNA fragments,containing the CACCC motif of the beta globin
    promoter,acting both as a transcriptional activator and repressor

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000987core promoter proximal region sequence-specific DNA binding IDA--
    GO:0001010sequence-specific DNA binding transcription factor recruiting transcription factor activity ISS--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP--
    GO:0001085RNA polymerase II transcription factor binding ISS--
    GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA--
         
    Find genes that share ontologies with KLF4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLF4:
     Decreased viability with pacli 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Klf4):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     homeostasis/metabolism  integument  mortality/aging  normal  reproductive system 
     tumorigenesis 

    Find genes that share phenotypes with KLF4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KLF4: Klf4tm1.1Khk Klf4tm1Efu

       genOway: Develop your customized and physiologically relevant rodent model for KLF4

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GCCACACCCA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLF4:
    hsa-mir-30b-5p (MIRT046110), hsa-mir-124-3p (MIRT022234), hsa-mir-335-5p (MIRT016880), hsa-mir-128-3p (MIRT021926), hsa-mir-135b-5p (MIRT005440), hsa-mir-107 (MIRT006692), hsa-mir-10b-5p (MIRT003216), hsa-mir-145-5p (MIRT000308), hsa-mir-25-3p (MIRT003605), hsa-mir-130a-3p (MIRT005674), hsa-mir-103a-3p (MIRT006688)

    Block miRNA regulation of human, mouse, rat KLF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF4 (see all 65):
    hsa-miR-579 hsa-miR-520f hsa-miR-300 hsa-miR-128 hsa-miR-632 hsa-miR-200b hsa-miR-4273 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidKLF4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KLF4
    Predesigned siRNA for gene silencing in human, mouse, rat KLF4

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for KLF4 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF4_HUMAN, O43474: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin ----
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with KLF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLF4 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Synthesis, Secretion, and Deacylation of Ghrelin0.00
    2L1CAM interactions
    Developmental Biology0.63
    3Fatty acid, triacylglycerol, and ketone body metabolism
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch


    Find genes that share SuperPaths with KLF4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for KLF4
        Wnt / Hedgehog / Notch

    2 BioSystems Pathways for KLF4
        SRF and miRs in Smooth Muscle Differentiation and Proliferation
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    3 Reactome Pathways for KLF4
        Synthesis, secretion, and deacylation of Ghrelin
    Transcriptional regulation of white adipocyte differentiation
    Transcriptional regulation of pluripotent stem cells


        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLF4: 
              Stem Cell Transcription Factors in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KLF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KLF4 (O434741, 2, 3 ENSP000003638044) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000230336Q018603, ENSP000004000474I2D: score=2 STRING: ENSP00000400047
    ENSG00000235068Q018603, ENSP000004050414I2D: score=2 STRING: ENSP00000405041
    ENSG00000237582Q018603, ENSP000003916814I2D: score=2 STRING: ENSP00000391681
    POU5F1Q018603, ENSP000002599154I2D: score=2 STRING: ENSP00000259915
    ENSG00000206454Q018603I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 40):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter ISS--
    GO:0007500mesodermal cell fate determination TAS8940147
    GO:0008285negative regulation of cell proliferation TAS8702718

    Find genes that share ontologies with KLF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF4

    8 Novoseek inferred chemical compound relationships for KLF4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 57.2 28 9218496 (2), 9422764 (1), 9443972 (1), 12518228 (1) (see all 19)
    butyrate 34.6 14 15051827 (8), 18264726 (1), 19327128 (1), 11005769 (1) (see all 5)
    oligonucleotide 23.3 6 9443972 (1), 17017123 (1), 12900388 (1), 19858207 (1)
    biotin 18.5 7 16959947 (2), 19056639 (1)
    pd 98,059 6.18 1 16077033 (1)
    ornithine 2.16 2 15570219 (1), 12297499 (1)
    thymidine 0 5 11322789 (1), 11005769 (1)
    nitric oxide 0 5 17339326 (1), 20073046 (1), 16169848 (1), 19858207 (1)



    Find genes that share compounds with KLF4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLF4 gene: 
    NM_004235.4  

    Unigene Cluster for KLF4:

    Kruppel-like factor 4 (gut)
    Hs.376206  [show with all ESTs]
    Unigene Representative Sequence: NM_004235
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497048(uc004bdf.2) ENST00000493306(uc022blk.1) ENST00000374672(uc004bdg.3 uc004bdh.3)
    ENST00000411706 ENST00000420475
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    SwitchGear 3'UTR luciferase reporter plasmidKLF4 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for KLF4 
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat KLF4
      QuantiFast Probe-based Assays in human, mouse, rat KLF4

    Additional mRNA sequence: 

    AF022184.1 AF105036.1 AK313489.1 BC029923.1 BC030811.1 HF546201.1 HF546202.1 HF546213.1 
    HM026463.1 U70663.1 

    11 DOTS entries:

    DT.315747  DT.97854059  DT.100029688  DT.100029691  DT.91642375  DT.121168852  DT.91727640  DT.99945043 
    DT.100751395  DT.121168874  DT.95268849 

    Selected AceView cDNA sequences (see all 147):

    AW074303 BM823002 AA298494 AA298805 CR599303 NM_004235 CA405483 AI687397 
    AI014784 AW196645 AA573434 AI537449 AI568487 CD678426 AK095894 AI266211 
    BU752888 BG681151 AW418765 AA236239 AI809670 AK095134 AA687950 AW515335 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAAATAGC
    KLF4 Expression
    About this image


    KLF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 13 entries
             Inner Cell Mass Cells Inner Cell Mass
             B6 mouse embryonic stem cells
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Chondrocytes Zeugopod Epiphyseal End
             Bone Marrow
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Schwann Precursor Cells Peripheral Nerve Domain
             Schwann cells
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Mature Granulosa Cells Antral Follicle
             Secondary follicles
    KLF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.376206
        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLF4: 
              Stem Cell Transcription Factors in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat KLF4
    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLF4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf41 , 5 Kruppel-like factor 4 (gut)1, 5 88.52(n)1
    92.02(a)1
      4 (29.76 cM)5
    166001  NM_010637.31  NP_034767.21 
     555271435 
    chicken
    (Gallus gallus)
    Aves KLF41 Kruppel-like factor 4 (gut) 70.35(n)
    67.57(a)
      770254  XM_004949369.1  XP_004949426.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLF46
    Kruppel-like factor 4 (gut)
    65(a)
    1 ↔ 1
    GL343218.1(2364834-2377765)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klf41 Kruppel-like factor 4 (gut) 61.13(n)
    61.04(a)
      550034  NM_001017280.2  NP_001017280.1 
    zebrafish
    (Danio rerio)
    Actinopterygii klf4a1 Kruppel-like factor 4a 57.35(n)
    57.96(a)
      562155  NM_001113483.1  NP_001106955.1 


    ENSEMBL Gene Tree for KLF4 (if available)
    TreeFam Gene Tree for KLF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF4 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  
    SP22  KLF102  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    Selected SIMAP similar genes for KLF4 using alignment to 6 protein entries:     KLF4_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    KLF7    KLF1    KLF2    ZFP1    ZNF112
    ZNF19    ZNF83    ZNF544    ZNF665    DKFZp686O1631    HKR1
    ZIC1    ZNF253    ZNF56    ZNF585B    ZNF671    ZNF708

    Find genes that share paralogs with KLF4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KLF4
    PGOHUM00000260450


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF4 (see all 199)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123403101,2
    F,A--110246636(+) GCTGTA/GGGAAG 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs735257121,2
    C--110246661(+) CAGATG/ATGAGG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1413458551,2
    --110246689(+) CCACAC/GAAAAC 1 -- ds50010--------
    rs455908401,2
    C,F--110246695(-) AAAAAA/TGTTTT 1 -- ds50013Minor allele frequency- T:0.06NS WA 212
    rs2008576271,2
    C--110246696(+) AAACT-/TTTTTA
            
    TTTTT
    1 -- ds50010--------
    rs1809633811,2
    --110246701(+) TTTTTA/GTTTTT 1 -- ds50010--------
    rs1841438241,2
    --110246906(+) TTTTAA/CTCTTG 1 -- ds50010--------
    rs455623331,2
    C,F--110246983(-) AAAAAA/-CTATT 1 -- ds50012Minor allele frequency- -:0.02NS 92
    rs1898890271,2
    --110246991(+) TTTTTC/TAATAA 1 -- ds50010--------
    rs123404621,2
    F--110246995(+) TTAATA/TAAAAA 1 -- ds50011Minor allele frequency- T:0.03NA 120

    HapMap Linkage Disequilibrium report for KLF4 (110247133 - 110252763 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KLF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825028CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF4
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602253    OMIM disorders: --

    5 diseases for KLF4:    
    About MalaCards
    secretory meningioma    skin squamous cell carcinoma    esophageal cancer    colon cancer
    malaria

    1 disease from the University of Copenhagen DISEASES database for KLF4:
    Teratoma

    Find genes that share disorders with KLF4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for KLF4 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    squamous cell esophageal cancer 69.5 6 12439907 (3), 12518228 (1), 19361279 (1)
    colon cancer 63.4 31 12387883 (3), 16077033 (3), 12776194 (3), 15051827 (2) (see all 15)
    tumors 38.5 62 11103818 (4), 16357510 (2), 19503094 (2), 19717984 (2) (see all 33)
    carcinoma squamous cell 36.4 11 12439907 (2), 9553140 (1), 16357510 (1), 11103818 (1) (see all 8)
    familial adenomatous polyposis 36 4 11521200 (2), 10913614 (1), 12776194 (1)
    colorectal cancer 35.7 21 18264726 (5), 16814484 (5), 20385121 (2), 14724568 (2) (see all 6)
    gastric cancer 33.3 18 15805274 (5), 17614846 (3), 15825076 (2), 17085651 (2) (see all 6)
    cancer 32.8 37 12518228 (3), 12439907 (2), 18264726 (2), 16357509 (2) (see all 16)
    pancreatic cancer 26.3 6 18559508 (4), 10859317 (1), 19823826 (1)
    adenoma 24.1 15 18264726 (5), 10913614 (4), 17614846 (2), 17908689 (1) (see all 5)

    Genetic Association Database (GAD): KLF4
    Human Genome Epidemiology (HuGE) Navigator: KLF4 (3 documents)

    Export disorders for KLF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF4 gene, integrated from 10 sources (see all 292):
    (articles sorted by number of sources associating them with KLF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. (PubMed id 9422764)1, 2, 3, 9 Yet S.-F....Lee M.-E. (J. Biol. Chem. 1998)
    2. KLF4, p21 and context-dependent opposing forces in cancer. (PubMed id 16372018)1, 3, 9 Rowland B.D. and Peeper D.S. (Nat. Rev. Cancer 2006)
    3. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PubMed id 17688680)1, 4, 9 GutiAcrrez-Aguilar R....Neve B. (BMC Med. Genet. 2007)
    4. Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PubMed id 23134681)1, 2 Camacho-Vanegas O.... Martignetti J.A. (FASEB J. 2013)
    5. Cooperative transcriptional activation by Klf4, Meis2, and Pbx1. (PubMed id 21746878)1, 2 Bjerke G.A.... Wotton D. (Mol. Cell. Biol. 2011)
    6. Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. (PubMed id 20071344)1, 2 Zhang P.... Lu W. (J. Biol. Chem. 2010)
    7. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F.... Peng X. (Proteomics 2008)
    8. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (Diabetologia 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9314 HGNC: 6348 AceView: KLF4 Ensembl:ENSG00000136826 euGenes: HUgn9314
    ECgene: KLF4 H-InvDB: KLF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLF4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF4 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/klf4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLF4 gene:
    Search GeneIP for patents involving KLF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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