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Aliases for KLF4 Gene

Aliases for KLF4 Gene

  • Kruppel-Like Factor 4 (Gut) 2 3
  • GKLF 3 4 6
  • EZF 3 4 6
  • Epithelial Zinc Finger Protein EZF 3 4
  • Gut-Enriched Krueppel-Like Factor 3 4
  • Endothelial Kruppel-Like Zinc Finger Protein 3
  • Krueppel-Like Factor 4 3

External Ids for KLF4 Gene

Summaries for KLF4 Gene

GeneCards Summary for KLF4 Gene

KLF4 (Kruppel-Like Factor 4 (Gut)) is a Protein Coding gene. Diseases associated with KLF4 include esophageal cancer and malaria. Among its related pathways are L1CAM interactions and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and double-stranded DNA binding. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for KLF4 Gene

  • Transcription factor; can act both as activator and as repressor. Binds the 5-CACCC-3 core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Gene Wiki entry for KLF4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF4 Gene

Genomics for KLF4 Gene

Genomic Location for KLF4 Gene

Start:
107,484,852 bp from pter
End:
107,490,482 bp from pter
Size:
5,631 bases
Orientation:
Minus strand

Genomic View for KLF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF4 Gene

Proteins for KLF4 Gene

  • Protein details for KLF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43474-KLF4_HUMAN
    Recommended name:
    Krueppel-like factor 4
    Protein Accession:
    O43474
    Secondary Accessions:
    • B2R8S4
    • B3KT79
    • L0R3I6
    • L0R4N5
    • P78338
    • Q5T3J8
    • Q5T3J9
    • Q8N717
    • Q9UNP3

    Protein attributes for KLF4 Gene

    Size:
    513 amino acids
    Molecular mass:
    54671 Da
    Quaternary structure:
    • Interacts with POU5F1/OCT4 and SOX2 (By similarity). Interacts with MUC1 (via the C-terminal domain). Interacts with MEIS2 isoform 4 and PBX1 isoform PBX1a.
    SequenceCaution:
    • Sequence=AAB48399.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC03462.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD42165.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH29923.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH30811.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=ABG25917.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAG36271.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW59020.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW59021.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KLF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF4 Gene

Proteomics data for KLF4 Gene at MOPED

Post-translational modifications for KLF4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys32

Other Protein References for KLF4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF4 Gene

Domains for KLF4 Gene

Gene Families for KLF4 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • KLF :Kruppel-like transcription factors

Protein Domains for KLF4 Gene

UniProtKB/Swiss-Prot:

KLF4_HUMAN
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.:
    • O43474
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.:
    • O43474
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • O43474
genes like me logo Genes that share domains with KLF4: view

Function for KLF4 Gene

Molecular function for KLF4 Gene

GENATLAS Biochemistry: Kruppel-like factor 4 (gut),zinc finger protein,mouse EZF and GKLF homolog,nuclear,expressed in select tissues,colon,testis,lung and small intestine,binding DNA fragments,containing the CACCC motif of the beta globin promoter,acting both as a transcriptional activator and repressor
UniProtKB/Swiss-Prot Function: Transcription factor; can act both as activator and as repressor. Binds the 5-CACCC-3 core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Gene Ontology (GO) - Molecular Function for KLF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000987 core promoter proximal region sequence-specific DNA binding IDA 21539536
GO:0001010 sequence-specific DNA binding transcription factor recruiting transcription factor activity ISS --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 21539536
GO:0001085 RNA polymerase II transcription factor binding ISS --
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA 21539536
genes like me logo Genes that share ontologies with KLF4: view
genes like me logo Genes that share phenotypes with KLF4: view

Animal Models for KLF4 Gene

MGI Knock Outs for KLF4:
Targeting motifs for KLF4 Gene
HOMER Transcription Factor Regulatory Elements motif KLF4
  • Consensus sequence: GCCACACCCA Submotif: canonical Cell Type: mES GeoId: GSE11431

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for KLF4 Gene

Localization for KLF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF4 Gene COMPARTMENTS Subcellular localization image for KLF4 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 1

Gene Ontology (GO) - Cellular Components for KLF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin --
GO:0000790 nuclear chromatin IDA 21539536
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with KLF4: view

Pathways for KLF4 Gene

genes like me logo Genes that share pathways with KLF4: view

Gene Ontology (GO) - Biological Process for KLF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 20551324
GO:0006357 regulation of transcription from RNA polymerase II promoter --
GO:0006366 transcription from RNA polymerase II promoter ISS --
GO:0007500 mesodermal cell fate determination TAS 8940147
GO:0008285 negative regulation of cell proliferation TAS 8702718
genes like me logo Genes that share ontologies with KLF4: view

Compounds for KLF4 Gene

(8) Novoseek inferred chemical compound relationships for KLF4 Gene

Compound -log(P) Hits PubMed IDs
zinc 57.2 20
butyrate 34.6 12
oligonucleotide 23.3 4
biotin 18.5 3
pd 98,059 6.18 1
genes like me logo Genes that share compounds with KLF4: view

Transcripts for KLF4 Gene

Unigene Clusters for KLF4 Gene

Kruppel-like factor 4 (gut):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF4 Gene

No ASD Table

Relevant External Links for KLF4 Gene

GeneLoc Exon Structure for
KLF4
ECgene alternative splicing isoforms for
KLF4

Expression for KLF4 Gene

mRNA expression in normal human tissues for KLF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (7.2) and Skin - Sun Exposed (Lower leg) (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLF4 Gene

SOURCE GeneReport for Unigene cluster for KLF4 Gene Hs.376206

genes like me logo Genes that share expressions with KLF4: view

Orthologs for KLF4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF4 36
  • 99.72 (n)
  • 100 (a)
KLF4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLF4 36
  • 91.54 (n)
  • 95.74 (a)
KLF4 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF4 36
  • 80.43 (n)
  • 81.65 (a)
KLF4 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf4 36
  • 88.52 (n)
  • 92.02 (a)
Klf4 16
Klf4 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF4 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF4 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf4 36
  • 88.35 (n)
  • 92.42 (a)
chicken
(Gallus gallus)
Aves KLF4 36
  • 70.35 (n)
  • 67.57 (a)
KLF4 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF4 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf4 36
  • 61.13 (n)
  • 61.04 (a)
zebrafish
(Danio rerio)
Actinopterygii klf4a 36
  • 57.35 (n)
  • 57.96 (a)
klf4a 37
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9895 38
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 38
  • 56 (a)
mua-1 38
  • 65 (a)
F56F11.3 38
  • 79 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.290 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
Species with no ortholog for KLF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF4 Gene

ENSEMBL:
Gene Tree for KLF4 (if available)
TreeFam:
Gene Tree for KLF4 (if available)

Paralogs for KLF4 Gene

Pseudogenes.org Pseudogenes for KLF4 Gene

genes like me logo Genes that share paralogs with KLF4: view

Variants for KLF4 Gene

Sequence variations from dbSNP and Humsavar for KLF4 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1059912 -- 107,487,484(-) CACAC(A/G)ACTTC missense, reference
rs1059913 - 107,487,450(-) CAGGA(C/G)TACCC reference, missense
rs1059914 - 107,487,433(-) TGGGT(C/T)TTGAG reference, missense
rs1059915 -- 107,487,407(-) AGGGA(A/C/T)TGTCA missense, reference, synonymous-codon
rs2236599 -- 107,487,224(-) CACGG(A/G)ATGAT intron-variant, synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for KLF4 Gene

Variant ID Type Subtype PubMed ID
nsv825028 CNV Gain 20364138

Relevant External Links for KLF4 Gene

HapMap Linkage Disequilibrium report
KLF4

Disorders for KLF4 Gene

(1) University of Copenhagen DISEASES for KLF4 Gene

(23) Novoseek inferred disease relationships for KLF4 Gene

Disease -log(P) Hits PubMed IDs
squamous cell esophageal cancer 69.5 5
colon cancer 63.4 23
tumors 38.5 47
carcinoma squamous cell 36.4 9
familial adenomatous polyposis 36 4

Relevant External Links for KLF4

Genetic Association Database (GAD)
KLF4
Human Genome Epidemiology (HuGE) Navigator
KLF4
genes like me logo Genes that share disorders with KLF4: view

No data available for UniProtKB/Swiss-Prot for KLF4 Gene

Publications for KLF4 Gene

  1. Human EZF, a Kruppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. (PMID: 9422764) Yet S.-F. … Lee M.-E. (J. Biol. Chem. 1998) 2 3 4 23
  2. KLF4, p21 and context-dependent opposing forces in cancer. (PMID: 16372018) Rowland B.D. … Peeper D.S. (Nat. Rev. Cancer 2006) 2 3 23
  3. Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. (PMID: 15674344) Foster K.W. … Ruppert J.M. (Oncogene 2005) 3 23
  4. Identification of KrA1ppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer. (PMID: 14724568) Zhao W. … Yang V.W. (Oncogene 2004) 3 23
  5. KrA1ppel-like factor 4 is transactivated by butyrate in colon cancer cells. (PMID: 15051827) Chen Z.Y. … Tseng C.C. (J. Nutr. 2004) 3 23

Products for KLF4 Gene

  • Addgene plasmids for KLF4

Sources for KLF4 Gene

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