KLF3 Gene
protein-coding GIFtS : 54
GCID: GC04 P038668
Kruppel-like factor 3 (basic)
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Aliasesfor KLF3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Kruppel-Like Factor 3 (Basic) 1 2 Basic Kruppel Like Factor2 BKLF1 2 3 Basic Kruppel-Like Factor2 Basic Krueppel-Like Factor2 3 Krueppel-Like Factor 32 TEF-22 3 Transcript Ch1382 CACCC-Box-Binding Protein BKLF2 3
Export aliases for KLF3 gene to outside databases Previous GC identifers: GC04P038830 GC04P038500 GC04P038563 GC04P038488 GC04P038342 GC04P037989
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Summariesfor KLF3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: KLF3_HUMAN, P57682 Function : Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity)Gene Wiki entry for KLF3
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Genomic Viewsfor KLF3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016297.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KLF3 gene promoter: Sox5 RFX1 Pax-5 Sp1 p300 Lmo2 Nkx2-5 GATA-1 Other transcription factors Search SABiosciences Chromatin IP Primers for KLF3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KLF3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4p14 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p16.1-p15.2 KLF3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04P038668: view genomic region
(about GC identifiers )
Start:
38,665,790 bp from pter
End:
38,703,129 bp from pter
Size:
37,340 bases
Orientation:
plus strand
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Proteinsfor KLF3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KLF3_HUMAN, P57682 (See
protein sequence )Recommended Name: Krueppel-like factor 3 Size : 345 amino acids; 38829 Da
Subunit : Monomer (By similarity)
Subcellular location : Nucleus (Probable)
Secondary accessions : Q6PIR1 Q86TN0 Q9P2X6Alternative splicing : 2 isoforms : P57682-1 P57682-2 (May be due to intron retention. No experimental confirmation available)Explore the universe of human proteins at neXtProt for KLF3: NX_P57682 Post-translational modifications:
Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-198 is the major site (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P57682 KLF3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_057615.3 ENSEMBL proteins: ENSP00000261438 ENSP00000421252 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
KLF3 for ontologies About GeneDecksing KLF3 Antibody Products: Assay Products for KLF3:
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Protein
Domains / Familiesfor KLF3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
KLF3 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P57682 ProtoNet protein and cluster: P57682
UniProtKB/Swiss-Prot: KLF3_HUMAN, P57682 Similarity : Belongs to the krueppel C2H2-type zinc-finger protein familySimilarity : Contains 3 C2H2-type zinc fingers
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Functionfor KLF3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: KLF3_HUMAN, P57682 Function : Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLF3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLF3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLF3 (NM_016531 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLF3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLF3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF3
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
KLF3 for ontologies About GeneDecksing 2 GenomeRNAi human phenotypes for KLF3 :Animal Models: Mouse knock-out Klf3 tm1Merc for KLF3 5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Klf3) :
KLF3 for phenotypes About GeneDecksing
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Pathways & Interactionsfor KLF3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLF3 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)3 Interacting proteins for KLF3 (P57682 3 ENSP00000261438 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
-- -- GO:0007275 multicellular organismal development
TAS 10582345
KLF3 for ontologies About GeneDecksing
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Drugs & Compoundsfor KLF3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
KLF3 for compounds About GeneDecksing Browse Tocris compounds for KLF3 1 Novoseek chemical compound relationship for KLF3 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
zinc
50
4
12736264 (1), 15684403 (1), 9724649 (1)
Search CenterWatch for drugs/clinical trials and news about KLF3
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Transcriptsfor KLF3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for KLF3 gene: NM_016531.5 Unigene Cluster for KLF3:
Kruppel-like factor 3 (basic) Hs.298658 [show with all ESTs ] Unigene Representative Sequence: NM_016531 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000261438 (uc003gth.4 ) ENST00000514033 (uc003gtg.2 ) ENST00000482150 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLF3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLF3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLF3 (NM_016531 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLF3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLF3
Additional cDNA sequence: AB024523.1 AF285837.1 AK313459.1 BC030662.1 BC051687.1 S77393.1
11 DOTS entries : DT.109048 DT.217403
DT.91696123 DT.100783681 DT.95273910 DT.91722098 DT.92427577 DT.121268994 DT.95273913 DT.108950 DT.121268995 24/243 AceView cDNA sequences (see all 243 ):
AW519312 AL597743 CB960588 BG260937 AA677127 BU676884 BQ102315 AB024523 BQ006234 F02805 BM718722 BQ102200 BM839249 BQ024659 CK905730 BQ086212 CK822825 Z39390 AA386075 F03710 AI275525 BM127245 BX116195 CB959566 GeneLoc Exon Structure
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Expression for KLF3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KLF3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCAAACTGTG
About this image KLF3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See KLF3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KLF3 SOURCE GeneReport for Unigene cluster: Hs.298658 SABiosciences Expression via Pathway-Focused PCR Array including KLF3 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KLF3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat KLF3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KLF3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KLF3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF3
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Orthologsfor KLF3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for KLF3 gene from 5/20 species (see all 20 ) About this table
ENSEMBL Gene Tree for KLF3 (if available)TreeFam Gene Tree for KLF3 (if available)
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Paralogsfor KLF3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KLF3 gene KLF1 2 KLF11 2 KLF6 2 KLF10 2 KLF4 2 KLF5 2 KLF14 2 KLF16 2 KLF2 2 KLF15 2 KLF12 2 KLF9 2 KLF7 2 KLF13 2 KLF8 2 7 SIMAP similar genes for KLF3 using alignment to 1 protein entry: KLF3_HUMAN :DKFZp313F0536 KLF7 KLF6 KLF4 KLF12 KLF5 KLF8
KLF3 for paralogs About GeneDecksing 2 Pseudogenes.org Pseudogenes for KLF3 PGOHUM00000238242 PGOHUM00000235453
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Genomic Variantsfor KLF3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for KLF3 1 CNV : 68703 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KLF3
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Disorders
/ Diseasesfor KLF3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
KLF3 for disorders About GeneDecksing
OMIM gene information: 609392
OMIM disorders : --5 diseases for KLF3 : About MalaCards stomach cancer myeloid leukemia hematopoiesis leukemia hepatitis Genetic Association Database (GAD): KLF3 Human Genome Epidemiology (HuGE) Navigator: KLF3 (5 documents) Export disorders for KLF3 gene to outside databases
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Publicationsfor KLF3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KLF3 gene, integrated from 9 sources (see all 38 ): (articles sorted by number of sources associating them with KLF3) Utopia : connect your pdf to the dynamic world of online information
cDNA cloning, subcellular localization and tissue expression of a new human Kruppel-like transcription factor: human basic Kruppel-like factor (hBKLF). (PubMed id 12812068) 1 , 2 , 9 Wang M.J.... He F.C. (2003) Targeted disruption of the basic Kruppel-like factor gene (Klf3) reveals a role in adipogenesis. (PubMed id 18391014) 1 , 3 Sue N....Crossley M. (2008) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668) 1 , 4 Kanazawa A....Maeda S. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Role for SUMO modification in facilitating transcriptional repression by BKLF. (PubMed id 15684403) 1 , 9 Perdomo J....Crossley M. (2005) Cloning and characterization of mCtBP2, a co-repressor that associates with basic Kruppel-like factor and other mammalian transcriptional regulators. (PubMed id 9724649) 1 , 9 Turner J. and Crossley M. (1998) The LIM protein FHL3 binds basic Kruppel-like factor/Kruppel-like factor 3 and its co-repressor C-terminal-binding protein 2. (PubMed id 12556451) 1 , 9 Turner J....Crossley M. (2003) Impaired B cell development in the absence of KrA1ppel -like factor 3. (PubMed id 22003205) 1 Vu T.T....Crossley M. (2011) The mammalian zinc finger transcription factor KrA1ppe l-like factor 3 (KLF3/BKLF). (PubMed id 21360637) 1 Pearson R.C....Crossley M. (2011)
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External Searches for KLF3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KLF3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KLF3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing KLF3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for KLF3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KLF3 gene: Search GeneIP for patents involving KLF3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KLF3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for KLF3 OriGene shRNA RFP for KLF3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for KLF3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for KLF3 OriGene Protein Over-expression Lysate for KLF3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KLF3 OriGene 3'-UTR Clone for KLF3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for KLF3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for KLF3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KLF3 OriGene Custom Protein Services for KLF3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLF3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing KLF3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat KLF3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat KLF3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat KLF3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat KLF3
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KLF3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF3
ThermoFisher Antibodies for KLF3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat KLF3
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Aliases for KLF3
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Disorders / Diseases for KLF3
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Expression for KLF3
Function for KLF3
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Pathways / Interactions for KLF3
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