Aliases for KLF2 Gene
External Ids for KLF2 Gene
Previous GeneCards Identifiers for KLF2 Gene
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011]
GeneCards Summary for KLF2 Gene
KLF2 (Kruppel Like Factor 2) is a Protein Coding gene. Diseases associated with KLF2 include Splenic Marginal Zone Lymphoma. Among its related pathways are FoxO signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is KLF4.
UniProtKB/Swiss-Prot for KLF2 Gene
Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.