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KLF2 Gene

protein-coding   GIFtS: 53
GCID: GC19P016435

Kruppel-Like Factor 2

(Previous name: Kruppel-like factor 2 (lung))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kruppel-Like Factor 21 2     Krueppel-Like Factor 22
LKLF2 3 5     Kruppel-Like Factor LKLF2
Kruppel-Like Factor 2 (Lung)1 2     Lung Kruppel-Like Zinc Finger Transcription Factor2
Lung Krueppel-Like Factor2 3     

External Ids:    HGNC: 63471   Entrez Gene: 103652   Ensembl: ENSG000001275287   OMIM: 6020165   UniProtKB: Q9Y5W33   

Export aliases for KLF2 gene to outside databases

Previous GC identifers: GC19P016929 GC19P016827 GC19P016280 GC19P016296 GC19P016007


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLF2 Gene:
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates
T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the
selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 (PubMed 19592277)).(supplied by OMIM, Feb
2011)

GeneCards Summary for KLF2 Gene:
KLF2 (Kruppel-like factor 2) is a protein-coding gene. Diseases associated with KLF2 include sickle cell anemia, and vascular disease. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3
Function: Binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity)

Gene Wiki entry for KLF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the KLF2 gene promoter:
         C/EBPbeta   FOXC1   AP-1   ATF-2   c-Jun   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF2 promoter sequence
   Search Chromatin IP Primers for KLF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

KLF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P016435:  view genomic region     (about GC identifiers)

Start:
16,435,628 bp from pter      End:
16,438,685 bp from pter
Size:
3,058 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3 (See protein sequence)
Recommended Name: Krueppel-like factor 2  
Size: 355 amino acids; 37420 Da
Subunit: Interacts with WWP1
Secondary accessions: Q6IPC4 Q9UJS5 Q9UKR6

Explore the universe of human proteins at neXtProt for KLF2: NX_Q9Y5W3

Explore proteomics data for KLF2 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057354.1  
    ENSEMBL proteins: 
     ENSP00000248071   ENSP00000465035  

    KLF2 Human Recombinant Protein Products:

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    Novus Biologicals KLF2 Proteins
    Novus Biologicals KLF2 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for KLF2

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    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KLF2
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    Search for Antibodies for KLF2 at Abcam
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    LSBio Antibodies in human, mouse, rat for KLF2

    KLF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for KLF2
    Cloud-Clone Corp. CLIAs for KLF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y5W3

    ProtoNet protein and cluster: Q9Y5W3

    UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    KLF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF2_HUMAN, Q9Y5W3
    Function: Binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity)

         Genatlas biochemistry entry for KLF2:
    Kruppel-like factor 2 (lung),zinc finger transcription factor,homolog of a mouse gene,predominantly expressed in
    developing lung,spleen and vascular system,putatively involved in programming the quiescent state of single
    positive T cells and blood wall morphogenesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    KLF2 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Klf2):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  normal  respiratory system  skeleton 

    KLF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KLF2: Klf2tm1Ling Klf2tm1Jml

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KLF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLF2:
    hsa-mir-124-3p (MIRT023028), hsa-mir-92a-3p (MIRT006372)

    Block miRNA regulation of human, mouse, rat KLF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF2 (see all 17):
    hsa-miR-3910 hsa-miR-16-2* hsa-miR-137 hsa-miR-25 hsa-miR-767-5p hsa-miR-1323 hsa-miR-92b hsa-miR-4280
    SwitchGear 3'UTR luciferase reporter plasmidKLF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLF2
    Predesigned siRNA for gene silencing in human, mouse, rat KLF2

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for KLF2 (see all 6)
    OriGene ORF clones in mouse, rat for KLF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLF2 (NM_016270)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for KLF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for KLF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF2_HUMAN, Q9Y5W3: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    KLF2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct 3 4
    Selected targets of Oct 3 4
    2FoxO signaling pathway
    FoxO signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for KLF2):
        FoxO signaling pathway


    KLF2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLF2: 
              Stem Cell Transcription Factors in human mouse rat
              Atherosclerosis in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KLF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for KLF2 (Q9Y5W33 ENSP000002480714) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF1Q9HCE73, ENSP000003546214I2D: score=1 STRING: ENSP00000354621
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    WWP1Q9H0M03, ENSP000002654284I2D: score=2 STRING: ENSP00000265428
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    GATA5Q9BWX53, ENSP000002529974I2D: score=1 STRING: ENSP00000252997
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0032715negative regulation of interleukin-6 production IEA--
    GO:0034101erythrocyte homeostasis ----

    KLF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF2

    2 Novoseek inferred chemical compound relationships for KLF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 40.3 14 7565748 (3), 9443972 (1), 10217429 (1), 10458913 (1) (see all 7)
    nitric oxide 32.5 9 16049344 (2), 16945356 (1), 15718498 (1), 19151844 (1) (see all 7)



    KLF2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLF2 gene: 
    NM_016270.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248071(uc002ndw.3) ENST00000592003
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF2 (see all 17):
    hsa-miR-3910 hsa-miR-16-2* hsa-miR-137 hsa-miR-25 hsa-miR-767-5p hsa-miR-1323 hsa-miR-92b hsa-miR-4280
    SwitchGear 3'UTR luciferase reporter plasmidKLF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for KLF2
    Predesigned siRNA for gene silencing in human, mouse, rat KLF2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLF2 (NM_016270)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for KLF2
    OriGene qSTAR qPCR primer pairs in human, mouse for KLF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF2
      QuantiTect SYBR Green Assays in human, mouse, rat KLF2
      QuantiFast Probe-based Assays in human, mouse, rat KLF2

    Selected AceView cDNA sequences (see all 428):

    BE676889 BE671183 AI365555 AI440534 AI356473 AI056449 AI475924 CK818814 
    AI762800 AI568951 AI086030 AI361714 AI005011 AI681655 AI568406 AI521318 
    AW131490 AI439562 BE675115 BE218644 AI077330 AI057044 BE674783 AI694057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCCGGGAC
    KLF2 Expression
    About this image


    KLF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Chondrocytes Zeugopod Epiphyseal End
             Membranous Facial Bones
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             B6 mouse embryonic stem cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
    KLF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF2 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLF2: 
              Stem Cell Transcription Factors in human mouse rat
              Atherosclerosis in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KLF2
    OriGene qSTAR qPCR primer pairs in human, mouse for KLF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF2
    QuantiTect SYBR Green Assays in human, mouse, rat KLF2
    QuantiFast Probe-based Assays in human, mouse, rat KLF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLF2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf21 , 5 Kruppel-like factor 2 (lung)1, 5 81.87(n)1
    86.69(a)1
      8 (34.99 cM)5
    165981  NM_008452.21  NP_032478.21 
     723190335 
    chicken
    (Gallus gallus)
    Aves KLF26
    Kruppel-like factor 2; Uncharacterized protein
    56(a)
    1 ↔ 1
    28(4146806-4149435)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    56(a)
    many ↔ many
    4(109086472-109093880)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043732.12   -- 76.62(n)    BC043732.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF392995.12   -- 78.42(n)   117509  AF392995.1 


    ENSEMBL Gene Tree for KLF2 (if available)
    TreeFam Gene Tree for KLF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for KLF2 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF72  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    9 SIMAP similar genes for KLF2 using alignment to 2 protein entries:     KLF2_HUMAN (see all proteins):
    KLF7    KLF12    KLF4    KLF9    ZNF702P    ZNF
    KLF16    KLF6    KLF5

    KLF2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for KLF2
    PGOHUM00000240305 PGOHUM00000240310 PGOHUM00000240908 PGOHUM00000240932


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF2 (see all 106)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760622801,2
    F--16433894(+) ACCCCC/GTGGGT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1490794271,2
    C--16433896(+) CCCCTC/GGGTGA 1 -- us2k10--------
    rs1830356631,2
    --16433918(+) TCCCCA/GTTTTC 1 -- us2k10--------
    rs1129159961,2
    --16434052(+) AGGCCG/AAGGCG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs48084841,2
    C,F--16434170(+) GCACCT/CTGTAA 1 -- us2k16Minor allele frequency- C:0.08NS NA WA EA 336
    rs1431554331,2
    --16434193(+) GGGAGG/TCTAAG 1 -- us2k10--------
    rs2006503891,2
    C--16434228(+) AGTTCA/GAGGCT 1 -- us2k10--------
    rs1921293661,2
    C--16434418(+) GCAGAC/TAGTTG 1 -- us2k10--------
    rs110860281,2
    C,F,A,H--16434454(+) GCAGGA/GATATG 1 -- us2k125Minor allele frequency- G:0.41NS EA NA WA CSA 2446
    rs455918321,2
    C,F--16434519(+) TGATGC/ACCCCG 1 -- us2k12Minor allele frequency- A:0.01NS 94

    HapMap Linkage Disequilibrium report for KLF2 (16435628 - 16438685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KLF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3753n71CNV Loss21882294
    nsv911159CNV Loss21882294
    dgv3754n71CNV Loss21882294
    nsv833767CNV Loss17160897
    nsv911163CNV Loss21882294
    nsv911162CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602016    OMIM disorders: --

    15 diseases for KLF2:    
    About MalaCards
    sickle cell anemia    vascular disease    labyrinthitis    oral cancer
    endotheliitis    hypoxia    atherosclerosis    acute myeloid leukemia
    myeloid leukemia    lung cancer    leukemia    hiv-1
    neuroblastoma    alzheimer's disease    hepatitis


    KLF2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for KLF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 32.1 2 15361832 (2)
    vascular diseases 29.9 1 16043642 (1)
    necrosis 7.38 1 18778280 (1)
    tumors 0 1 15735666 (1)

    Genetic Association Database (GAD): KLF2
    Human Genome Epidemiology (HuGE) Navigator: KLF2 (3 documents)

    Export disorders for KLF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF2 gene, integrated from 10 sources (see all 111):
    (articles sorted by number of sources associating them with KLF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor. (PubMed id 10458913)1, 2, 3, 9 Wani M.A.... Lingrel J.B. (Genomics 1999)
    2. Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus. (PubMed id 10217429)1, 2, 3, 9 Kozyrev S.V....Kisselev L.L. (FEBS Lett. 1999)
    3. A study of the relationships between KLF2 polymorphisms and body weight control in a French population. (PubMed id 16542423)1, 4, 9 Meirhaeghe A....Amouyel P. (BMC Med. Genet. 2006)
    4. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PubMed id 17688680)1, 4 GutiAcrrez-Aguilar R....Neve B. (BMC Med. Genet. 2007)
    5. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (Diabetologia 2005)
    6. Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. (PubMed id 11375995)1, 2 Conkright M.D.... Lingrel J.B. (J. Biol. Chem. 2001)
    7. KrA1ppel-like factor 2, a novel immediate-early transcriptional factor, regulates IL-2 expression in T lymphocyte activation. (PubMed id 16116194)1, 9 Wu J. and Lingrel J.B. (J. Immunol. 2005)
    8. Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis. (PubMed id 15735666)1, 9 Wang F....Smith D.I. (Oncogene 2005)
    9. WWP1-dependent ubiquitination and degradation of the lung KrA1ppel-like factor, KLF2. (PubMed id 15003522)1, 9 Zhang X....Lingrel J.B. (Biochem. Biophys. Res. Commun. 2004)
    10. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. (PubMed id 15718498)1, 9 Lin Z....Jain M.K. (Circ. Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10365 HGNC: 6347 AceView: KLF2 Ensembl:ENSG00000127528 euGenes: HUgn10365
    ECgene: KLF2 Kegg: 10365 H-InvDB: KLF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLF2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/klf2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLF2 gene:
    Search GeneIP for patents involving KLF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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