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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLF2 Gene

protein-coding   GIFtS: 54
GCID: GC19P016435

Kruppel-Like Factor 2 (Lung)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kruppel-Like Factor 2 (Lung)1 2
LKLF2 3 5
Lung Krueppel-Like Factor2 3
Krueppel-Like Factor 22
Kruppel-Like Factor LKLF2
Lung Kruppel-Like Zinc Finger Transcription Factor2

External Ids:    HGNC: 63471   Entrez Gene: 103652   Ensembl: ENSG000001275287   OMIM: 6020165   UniProtKB: Q9Y5W33   

Export aliases for KLF2 gene to outside databases

Previous GC identifers: GC19P016929 GC19P016827 GC19P016280 GC19P016296 GC19P016007


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLF2 Gene:
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates
T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the
selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 (PubMed 19592277)).(supplied by OMIM, Feb
2011)

GeneCards Summary for KLF2 Gene: 
KLF2 (Kruppel-like factor 2 (lung)) is a protein-coding gene. Diseases associated with KLF2 include sickle cell anemia, and paralysis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3
Function: Binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity)

Gene Wiki entry for KLF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLF2 gene promoter:
         C/EBPbeta   FOXC1   AP-1   ATF-2   c-Jun   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

KLF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P016435:  view genomic region     (about GC identifiers)

Start:
16,435,628 bp from pter      End:
16,438,685 bp from pter
Size:
3,058 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3 (See protein sequence)
Recommended Name: Krueppel-like factor 2  
Size: 355 amino acids; 37420 Da
Subunit: Interacts with WWP1
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q6IPC4 Q9UJS5 Q9UKR6

Explore the universe of human proteins at neXtProt for KLF2: NX_Q9Y5W3

Explore proteomics data for KLF2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5W3

  • KLF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLF2 Protein Expression
    REFSEQ proteins: NP_057354.1  
    ENSEMBL proteins: 
     ENSP00000248071   ENSP00000465035  

    Human Recombinant Protein Products for KLF2: 
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    Novus Biologicals KLF2 Proteins
    Novus Biologicals KLF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLF2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    KLF2 for ontologies           About GeneDecksing



    KLF2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for KLF2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y5W3

    ProtoNet protein and cluster: Q9Y5W3

    UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    KLF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF2_HUMAN, Q9Y5W3
    Function: Binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity)

         Genatlas biochemistry entry for KLF2:
    Kruppel-like factor 2 (lung),zinc finger transcription factor,homolog of a mouse gene,predominantly expressed in
    developing lung,spleen and vascular system,putatively involved in programming the quiescent state of single
    positive T cells and blood wall morphogenesis

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    KLF2 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Klf2):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  normal  respiratory system  skeleton 

    KLF2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KLF2: Klf2tm1Ling Klf2tm1Jml

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KLF2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KLF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLF2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLF2 

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF2 (see all 17):
    hsa-miR-3910 hsa-miR-16-2* hsa-miR-137 hsa-miR-25 hsa-miR-767-5p hsa-miR-1323 hsa-miR-92b hsa-miR-4280
    SwitchGear 3'UTR luciferase reporter plasmidKLF2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLF2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct-3/4
    Selected targets of Oct-3/4

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KLF2
        Selected targets of Oct-3/4




    KLF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for KLF2 (Q9Y5W33 ENSP000002480714) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF1Q9HCE73, ENSP000003546214I2D: score=1 STRING: ENSP00000354621
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    WWP1Q9H0M03, ENSP000002654284I2D: score=2 STRING: ENSP00000265428
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    GATA5Q9BWX53, ENSP000002529974I2D: score=1 STRING: ENSP00000252997
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0032715negative regulation of interleukin-6 production IEA--
    GO:0034101erythrocyte homeostasis ----

    KLF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLF2

    2 Novoseek inferred chemical compound relationships for KLF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 40.3 14 7565748 (3), 9443972 (1), 10217429 (1), 10458913 (1) (see all 7)
    nitric oxide 32.5 9 16049344 (2), 16945356 (1), 15718498 (1), 19151844 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about KLF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLF2 gene: 
    NM_016270.2  

    Unigene Cluster for KLF2:

    Kruppel-like factor 2 (lung)
    Hs.744182  [show with all ESTs]
    Unigene Representative Sequence: AK225820
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248071(uc002ndw.3) ENST00000592003
    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF2 (see all 17):
    hsa-miR-3910 hsa-miR-16-2* hsa-miR-137 hsa-miR-25 hsa-miR-767-5p hsa-miR-1323 hsa-miR-92b hsa-miR-4280
    SwitchGear 3'UTR luciferase reporter plasmidKLF2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF134053.1 AF205849.1 AK225820.1 BC035342.1 BC071983.1 

    4 DOTS entries:

    DT.100751316  DT.454402  DT.100708469  DT.95198036 

    24/428 AceView cDNA sequences (see all 428):

    AI077330 AA318404 AI364729 AI438989 AI078575 AI076895 AI086030 BM703501 
    AI651189 AW772407 AI056449 BE676889 AI440373 BE675316 BE646655 BE674783 
    BE646418 AI809158 AI439655 BE218644 BE675454 AI356473 AI087996 AI762800 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLF2 expression in normal human tissues (normalized intensities)      KLF2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCCGGGAC
    KLF2 Expression
    About this image


    KLF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Chondrocytes Zeugopod Epiphyseal End
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             T Helper Cells Thymus
             neutrophils   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             sensory organ/ear/inner ear   
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Autopod
             limb/hindlimb   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             B6 mouse embryonic stem cells

    See KLF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLF2

    SOURCE GeneReport for Unigene cluster: Hs.744182
        SABiosciences Expression via Pathway-Focused PCR Arrays including KLF2: 
              Stem Cell Transcription Factors in human mouse rat
              Atherosclerosis in human mouse rat
              Adipogenesis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for KLF2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf21 , 5 Kruppel-like factor 2 (lung)1, 5 82.91(n)1
    88.1(a)1
      8 (34.99 cM)5
    165981  NM_008452.21  NP_032478.21 
     723190335 
    chicken
    (Gallus gallus)
    Aves KLF21 Kruppel-like factor 2 (lung) 68.06(n)
    65.37(a)
      420148  XM_418264.3  XP_418264.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLF26
    Kruppel-like factor 2 (lung)
    55(a)
    1 ↔ 1
    4(109086472-109093880)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043732.12   -- 76.62(n)    BC043732.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF392995.12   -- 78.42(n)   117509  AF392995.1 


    ENSEMBL Gene Tree for KLF2 (if available)
    TreeFam Gene Tree for KLF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLF2 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF72  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP92  
    SP72  
    9 SIMAP similar genes for KLF2 using alignment to 2 protein entries:     KLF2_HUMAN (see all proteins):
    KLF7    KLF4    KLF12    KLF9    ZNF702P    ZNF
    KLF16    KLF6    KLF5

    KLF2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for KLF2
    PGOHUM00000240305 PGOHUM00000240310 PGOHUM00000240908 PGOHUM00000240932


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/106 SNPs in KLF2 are shown (see all 106)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760622801,2
    F--16433894(+) ACCCCC/GTGGGT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1490794271,2
    C--16433896(+) CCCCTC/GGGTGA 1 -- us2k10--------
    rs1830356631,2
    --16433918(+) TCCCCA/GTTTTC 1 -- us2k10--------
    rs1129159961,2
    --16434052(+) AGGCCG/AAGGCG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs48084841,2
    C,F--16434170(+) GCACCT/CTGTAA 1 -- us2k16Minor allele frequency- C:0.08NS NA WA EA 336
    rs1431554331,2
    --16434193(+) GGGAGG/TCTAAG 1 -- us2k10--------
    rs2006503891,2
    C--16434228(+) AGTTCA/GAGGCT 1 -- us2k10--------
    rs1921293661,2
    C--16434418(+) GCAGAC/TAGTTG 1 -- us2k10--------
    rs110860281,2
    C,F,A,H--16434454(+) GCAGGA/GATATG 1 -- us2k125Minor allele frequency- G:0.41NS EA NA WA CSA 2446
    rs455918321,2
    C,F--16434519(+) TGATGC/ACCCCG 1 -- us2k12Minor allele frequency- A:0.01NS 94

    HapMap Linkage Disequilibrium report for KLF2 (16435628 - 16438685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KLF2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3753n71CNV Loss21882294
    nsv911159CNV Loss21882294
    dgv3754n71CNV Loss21882294
    nsv833767CNV Loss17160897
    nsv911163CNV Loss21882294
    nsv911162CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602016    OMIM disorders: --

    12 diseases for KLF2:    About MalaCards
    sickle cell anemia    paralysis    oral cancer    vascular disease
    endotheliitis    anemia    atherosclerosis    hypoxia
    myeloid leukemia    lung cancer    leukemia    hepatitis


    KLF2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for KLF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 32.1 2 15361832 (2)
    vascular diseases 29.9 1 16043642 (1)
    necrosis 7.38 1 18778280 (1)
    tumors 0 1 15735666 (1)

    Genetic Association Database (GAD): KLF2
    Human Genome Epidemiology (HuGE) Navigator: KLF2 (3 documents)

    Export disorders for KLF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLF2 gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with KLF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor. (PubMed id 10458913)1, 2, 3, 9 Wani M.A.... Lingrel J.B. (1999)
    2. Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus. (PubMed id 10217429)1, 2, 3, 9 Kozyrev S.V....Kisselev L.L. (1999)
    3. A study of the relationships between KLF2 polymorphisms and body weight control in a French population. (PubMed id 16542423)1, 4, 9 Meirhaeghe A....Amouyel P. (2006)
    4. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PubMed id 17688680)1, 4 Gutierrez-Aguilar R....Neve B. (2007)
    5. Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (2005)
    6. Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. (PubMed id 11375995)1, 2 Conkright M.D.... Lingrel J.B. (2001)
    7. Kruppel-like factor 2, a novel immediate-early transcriptional factor, regulates IL-2 expression in T lymphocyte activation. (PubMed id 16116194)1, 9 Wu J. and Lingrel J.B. (2005)
    8. Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis. (PubMed id 15735666)1, 9 Wang F....Smith D.I. (2005)
    9. WWP1-dependent ubiquitination and degradation of the lung Kruppel-like factor, KLF2. (PubMed id 15003522)1, 9 Zhang X....Lingrel J.B. (2004)
    10. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. (PubMed id 15718498)1, 9 Lin Z....Jain M.K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10365 HGNC: 6347 AceView: KLF2 Ensembl:ENSG00000127528 euGenes: HUgn10365
    ECgene: KLF2 H-InvDB: KLF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLF2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/klf2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLF2 gene:
    Search GeneIP for patents involving KLF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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