Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLF2 Gene

protein-coding   GIFtS: 52
GCID: GC19P016435

Kruppel-like factor 2 (lung)
 Explore 10 diseases affiliated with
KLF2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KLF2    

Aliases
for KLF2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kruppel-Like Factor 2 (Lung)1 2
LKLF1 2 3 5
Lung Krueppel-Like Factor2 3
Krueppel-Like Factor 22
Kruppel-Like Factor LKLF2
Lung Kruppel-Like Zinc Finger Transcription Factor2

External Ids:    HGNC: 63471   Entrez Gene: 103652   Ensembl: ENSG000001275287   OMIM: 6020165   UniProtKB: Q9Y5W33   

Export aliases for KLF2 gene to outside databases

Previous GC identifers: GC19P016929 GC19P016827 GC19P016280 GC19P016296 GC19P016007


Summaries
for KLF2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KLF2:
Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell
trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L
(SELL; MIM 153240) (summary by Weinreich et al., 2009 (PubMed 19592277)).(supplied by OMIM, Feb 2011)

UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3
Function: Binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity)

Gene Wiki entry for KLF2


Genomic Views
for KLF2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLF2 gene promoter:
         C/EBPbeta   FOXC1   AP-1   ATF-2   c-Jun   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

KLF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P016435:  view genomic region     (about GC identifiers)

Start:
 16,435,628 bp from pter      End:
 16,438,685 bp from pter
Size:
 3,058 bases      Orientation:
 plus strand

Proteins
for KLF2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3 (See protein sequence)
Recommended Name: Krueppel-like factor 2  
Size: 355 amino acids; 37420 Da
Subunit: Interacts with WWP1
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q6IPC4 Q9UJS5 Q9UKR6

Explore the universe of human proteins at neXtProt for KLF2: NX_Q9Y5W3

Post-translational modifications:

  • Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5W3

    • KLF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057354.1  
    ENSEMBL proteins: 
     ENSP00000248071   ENSP00000465035  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: KLF2
    OriGene Protein Over-expression Lysate: KLF2
    OriGene Custom Protein Services for KLF2 
    GenScript Custom Purified and Recombinant Proteins Services for KLF2
    Novus Biologicals KLF2 Proteins
    Novus Biologicals KLF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KLF2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    KLF2 for ontologies           About GeneDecksing



    KLF2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for KLF2
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for KLF2 
    GenScript Custom Superior Antibodies Services for KLF2
    Novus Biologicals KLF2 Antibodies
    Search for Antibodies for KLF2 at Abcam  
    Uscn Antibodies for KLF2
    Search ThermoFisher Antibodies for KLF2

    Assay Products for KLF2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for KLF2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for KLF2

    Protein Domains /
    Families
    for KLF2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KLF2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y5W3

    ProtoNet protein and cluster: Q9Y5W3

    UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Function
    for KLF2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KLF2_HUMAN, Q9Y5W3
    Function: Binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity)

         Genatlas biochemistry entry for KLF2:
    Kruppel-like factor 2 (lung),zinc finger transcription factor,homolog of a mouse gene,predominantly expressed in
    developing lung,spleen and vascular system,putatively involved in programming the quiescent state of single positive T
    cells and blood wall morphogenesis

    miRNA
    Products:            		 OriGene 3'-UTR Clone: KLF2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLF2
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF2 (see all 17):
    hsa-miR-3910 hsa-miR-16-2* hsa-miR-137 hsa-miR-25 hsa-miR-767-5p hsa-miR-1323 hsa-miR-92b hsa-miR-4280
    SwitchGear 3'UTR luciferase reporter plasmid: KLF2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF2 (see all 7)
    OriGene shRNA RFP: KLF2
    OriGene siRNA: KLF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for KLF2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KLF2 (NM_016270)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for KLF2
    Search LifeMap BioReagents cell lines for KLF2

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KLF2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    KLF2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for KLF2: Klf2tm1Ling Klf2tm1Jml
         14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Klf2):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  normal  respiratory system  skeleton 

    KLF2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for KLF2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of Oct-3/4
    		Selected targets of Oct-3/41.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for KLF2
        Selected targets of Oct-3/4




    KLF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for KLF2 (Q9Y5W33 ENSP000002480714) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF1Q9HCE73, ENSP000003546214I2D: score=1 STRING: ENSP00000354621
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    WWP1Q9H0M03, ENSP000002654284I2D: score=2 STRING: ENSP00000265428
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    GATA5Q9BWX53, ENSP000002529974I2D: score=1 STRING: ENSP00000252997
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0032715negative regulation of interleukin-6 production IEA--
    GO:0034101erythrocyte homeostasis ----


    KLF2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KLF2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLF2
    2 Novoseek chemical compound relationships for KLF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 40.3 14 7565748 (3), 9443972 (1), 10217429 (1), 10458913 (1) (see all 7)
    nitric oxide 32.5 9 16049344 (2), 16945356 (1), 15718498 (1), 19151844 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about KLF2 

    Transcripts
    for KLF2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KLF2 gene: 
    NM_016270.2  

    Unigene Cluster for KLF2:

    Kruppel-like factor 2 (lung)
    Hs.744182  [show with all ESTs]
    Unigene Representative Sequence: AK225820
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248071(uc002ndw.3) ENST00000592003

    miRNA
    Products:             		 OriGene 3'-UTR Clone: KLF2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLF2
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF2 (see all 17):
    hsa-miR-3910 hsa-miR-16-2* hsa-miR-137 hsa-miR-25 hsa-miR-767-5p hsa-miR-1323 hsa-miR-92b hsa-miR-4280
    SwitchGear 3'UTR luciferase reporter plasmid: KLF2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF2 (see all 7)
    OriGene shRNA RFP: KLF2
    OriGene siRNA: KLF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: KLF2 (NM_016270)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLF2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLF2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF2

    Additional cDNA sequence: 

    AF134053.1 AF205849.1 AK225820.1 BC035342.1 BC071983.1 

    4 DOTS entries:

    DT.100751316  DT.454402  DT.100708469  DT.95198036 

    24/428 AceView cDNA sequences (see all 428):

    BE676743 AI568951 BE675362 F36163 AI078575 BE674710 BE676510 AI440309 
    AI356474 CA437813 BE646056 AI762995 AI356432 AI762800 BE646655 BF448955 
    BE219005 BE646334 AI383909 BE676464 CB068387 AI378244 AI382630 AI538556 

    GeneLoc Exon Structure


    Expression
    for KLF2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGCCGGGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KLF2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    BoneAutopod Long BoneBone
    LimbAutopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Fetal cardiomyocytes (20 weeks) (Primary Cell)Heart, Myocardium
    Epiblast-like cells (Reconstitution of mo...)
    CD31, CD144 positive cells (Two-step protocol fo...)

    See KLF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLF2

    SOURCE GeneReport for Unigene cluster: Hs.744182
        SABiosciences Expression via Pathway-Focused PCR Arrays including KLF2: 
              Stem Cell Transcription Factors in human mouse rat
              Atherosclerosis in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLF2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLF2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF2
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KLF2

    Orthologs
    for KLF2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KLF2 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Klf21 , 5 Kruppel-like factor 2 (lung)1, 5 82.91(n)1
    88.1(a)1    		   8 (34.99 cM)5
    165981  NM_008452.21  NP_032478.21 
     723190335 
    chicken
    (Gallus gallus)    		 Aves KLF21 Kruppel-like factor 2 (lung) 68.06(n)
    65.37(a)    		   420148  XM_418264.3  XP_418264.1 
    lizard
    (Anolis carolinensis)    		 Reptilia KLF26
    --
    		 --
    		 67(a)
    5(a)
    		 possible ortholog
    possible ortholog
    		 4(109090962-109093568)
    3(88021848-88042132)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC043732.12   -- 76.62(n)    BC043732.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AF392995.12   -- 78.42(n)   117509  AF392995.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG98953 transcription factor 72(a)   59C1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea F56F11.33 zinc finger protein 79(a)
    (best of 3)    		   III(2946712-2952243)   --


    ENSEMBL Gene Tree for KLF2 (if available)
    TreeFam Gene Tree for KLF2 (if available) 

    Paralogs
    for KLF2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLF2 gene
    KLF12  KLF112  KLF62  KLF102  KLF42  KLF52  KLF142  KLF162  
    KLF152  KLF92  KLF122  KLF32  KLF72  KLF132  KLF82  
    11 SIMAP similar genes for KLF2 using alignment to 2 protein entries:     KLF2_HUMAN (see all proteins):
    DKFZp313F0536    KLF7    KLF12    KLF9    KLF4    ZNF702P
    ZNF    KLF16    KLF6    KLF5    KLF1

    KLF2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for KLF2
    PGOHUM00000240305 PGOHUM00000240310 PGOHUM00000240908 PGOHUM00000240932


    Genomic Variants
    for KLF2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/87 NCBI SNPs in KLF2 are shown (see all 87)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs760622801,2
    		--16433894(+) ACCCCC/GTGGGT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1490794271,2
    		--16433896(+) CCCCTC/GGGTGA 1 -- us2k10--------
    rs1830356631,2
    		--16433918(+) TCCCCA/GTTTTC 1 -- us2k10--------
    rs1129159961,2
    		--16434052(+) AGGCCG/AAGGCG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs48084841,2
    		C,F,--16434170(+) GCACCT/CTGTAA 1 -- us2k16Minor allele frequency- C:0.08NS NA WA EA 336
    rs1431554331,2
    		--16434193(+) GGGAGG/TCTAAG 1 -- us2k10--------
    rs1921293661,2
    		--16434418(+) GCAGAC/TAGTTG 1 -- us2k10--------
    rs110860281,2
    		C,F,A,H,--16434454(+) GCAGGA/GATATG 1 -- us2k125Minor allele frequency- G:0.41NS EA NA WA CSA 2446
    rs455918321,2
    		C,--16434519(+) TGATGC/ACCCCG 1 -- us2k12Minor allele frequency- A:0.01NS 94
    rs1511985991,2
    		--16434561(+) ATCACC/TGTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLF2 (16435628 - 16438685 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KLF2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF2
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF2

    Disorders / Diseases
    for KLF2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KLF2 for disorders           About GeneDecksing

    OMIM gene information: 602016    OMIM disorders: --

    10 diseases for KLF2:    About MalaCards
    sickle cell anemia    paralysis    myeloid leukemia    oral cancer
    anemia    leukemia    lung cancer    atherosclerosis
    hypoxia    hepatitis

    4 Novoseek disease relationships for KLF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 32.1 2 15361832 (2)
    vascular diseases 29.9 1 16043642 (1)
    necrosis 7.38 1 18778280 (1)
    tumors 0 1 15735666 (1)

    Genetic Association Database (GAD): KLF2
    Human Genome Epidemiology (HuGE) Navigator: KLF2 (3 documents)

    Export disorders for KLF2 gene to outside databases

    Publications
    for KLF2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLF2 gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with KLF2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor. (PubMed id 10458913)1, 2, 3, 9 Wani M.A.... Lingrel J.B. (1999)
    2. Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus. (PubMed id 10217429)1, 2, 3, 9 Kozyrev S.V....Kisselev L.L. (1999)
    3. Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (2005)
    4. Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase. (PubMed id 11375995)1, 2 Conkright M.D.... Lingrel J.B. (2001)
    5. Kruppel-like factor 2, a novel immediate-early transcriptional factor, regulates IL-2 expression in T lymphocyte activation. (PubMed id 16116194)1, 9 Wu J. and Lingrel J.B. (2005)
    6. Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis. (PubMed id 15735666)1, 9 Wang F....Smith D.I. (2005)
    7. WWP1-dependent ubiquitination and degradation of the lung Kruppel-like factor, KLF2. (PubMed id 15003522)1, 9 Zhang X....Lingrel J.B. (2004)
    8. Kruppel-like factor 2 (KLF2) regulates endothelial thrombotic function. (PubMed id 15718498)1, 9 Lin Z....Jain M.K. (2005)
    9. Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Kruppel-like factor: identification of a new multigene family. (PubMed id 7565748)1, 9 Anderson K.P....Lingrel J.B. (1995)
    10. Statins exert endothelial atheroprotective effects via the KLF2 transcription factor. (PubMed id 15878865)1, 9 Parmar K.M....Garcia-Cardena G. (2005)

    External Searches for KLF2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KLF2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10365 HGNC: 6347 AceView: KLF2 Ensembl:ENSG00000127528 euGenes: HUgn10365
    ECgene: KLF2 H-InvDB: KLF2

    Other Databases showing KLF2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KLF2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLF2 Pharmacogenomics, SNPs, Pathways
    SeattleSNPshttp://pga.gs.washington.edu/data/klf2/

    Intellectual Property
    for KLF2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KLF2 gene:
    Search GeneIP for patents involving KLF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KLF2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for KLF2 (KLF2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for KLF2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLF2  
     OriGene Protein Over-expression Lysate for KLF2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for KLF2   OriGene 3'-UTR Clone for KLF2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for KLF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for KLF2   OriGene Custom Protein Services for KLF2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLF2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF2
     GenScript Custom Purified and Recombinant Proteins Services for KLF2 GenScript cDNA clones with any tag delivered in your preferred vector for KLF2
     GenScript Custom Assay Services for KLF2 GenScript Custom Superior Antibodies Services for KLF2
     GenScript Custom overexpressing Cell Line Services for KLF2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in KLF2 promoter
     Search Chromatin IP Primers for KLF2
     RT2 qPCR Primer Assay in human, mouse, rat KLF2
     GNC Network for KLF2
     SABiosciences PCR Arrays including human, mouse, rat KLF2
     Search Tocris compounds for KLF2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     KLF2 antibodies
     KLF2 proteins
     KLF2 lysates
     Search for Antibodies for KLF2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for KLF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     KLF2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for KLF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for KLF2
     SwitchGear 3'UTR luciferase reporter plasmids for KLF2
     SwitchGear Promoter luciferase reporter plasmids for KLF2
     Search ThermoFisher Antibodies for KLF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      KLF2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4