KLF17 Gene
protein-coding GIFtS: 47
GCID: GC01P044584
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Kruppel-like factor 17(Previous name: zinc finger protein 393 )
(Previous symbol: ZNF393)
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Aliases
for KLF17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Kruppel-Like Factor 171 2 | | FLJ401601 | | ZNF3931 2 3 5 | | Krueppel-Like Factor 172 | | Zinc Finger Protein 3931 2 3 | | Novel Zinc-Finger Protein2 | | Zfp3931 2 | | |
Export aliases for KLF17 gene to outside databasesPrevious GC identifers: GC01P044357 GC01P042699 |
Summaries
for KLF17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KLF17_HUMAN, Q5JT82Function: Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as anegative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression.May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocytedevelopment (By similarity)
Gene Wiki entry for KLF17
|
Genomic Views
for KLF17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KLF17 gene promoter:
Bach1 ISGF-3 FOXO3 FOXD3 FOXO3b AREB6 FAC1 FOXO4 COMP1 FOXO3a
Other transcription factors
Search SABiosciences Chromatin IP Primers for KLF17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1KLF17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P044584: view genomic region
(about GC identifiers)
Start:
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44,584,522 bp from pter |
End:
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44,600,812 bp from pter |
Size:
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16,291 bases |
Orientation:
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plus strand |
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Proteins
for KLF17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KLF17_HUMAN, Q5JT82 (See
protein sequence)Recommended Name: Krueppel-like factor 17 Size: 389 amino acids; 42577 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: Q86VQ7 Q8N805Explore the universe of human proteins at neXtProt for KLF17: NX_Q5JT82
KLF17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775755.3
ENSEMBL proteins: ENSP00000361373
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
KLF17 for ontologies About GeneDecksing
KLF17 Antibody Products:
Assay Products for KLF17: |
Protein
Domains /
Families
for KLF17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLF17 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5JT82ProtoNet protein and cluster: Q5JT82 UniProtKB/Swiss-Prot: KLF17_HUMAN, Q5JT82Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein familySimilarity: Contains 3 C2H2-type zinc fingers |
Function
for KLF17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KLF17_HUMAN, Q5JT82Function: Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as anegative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression.May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocytedevelopment (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF17
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF17 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
ISS | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0044212 | transcription regulatory region DNA binding |
ISS | -- |
KLF17 for ontologies About GeneDecksing
|
Pathways & Interactions
for KLF17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLF17
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
ISS | -- | | GO:0007276 | gamete generation |
IEA | -- |
KLF17 for ontologies About GeneDecksing
|
Drugs & Compounds
for KLF17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KLF17
Search CenterWatch for drugs/clinical trials and news about KLF17
|
Transcripts
for KLF17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KLF17 gene: NM_173484.3 Unigene Cluster for KLF17: Kruppel-like factor 17 Hs.567674 [show with all ESTs]Unigene Representative Sequence: BC0498442 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372299(uc009vxf.1 uc001clp.3) ENST00000476802
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF17 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KLF17 (NM_173484) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLF17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF17 |
Additional cDNA sequence: AK097479.1 AK308458.1 BC035408.1 BC049844.1 1 DOTS entry: DT.100014537 9 AceView cDNA sequences: NM_173484 BC049844 BI825370 BI460100 AK097479 CA310442 BI825843 BC035408 BI827544
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for KLF17 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 |
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| SP1: | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for KLF17
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Expression
for KLF17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLF17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAGGAAGGT
About this image
See KLF17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLF17
SOURCE GeneReport for Unigene cluster: Hs.567674
SABiosciences Custom PCR Arrays for KLF17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLF17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLF17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF17 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF17 |
Orthologs
for KLF17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KLF17 gene from 2/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
3(a) |
possible ortholog |
3(88021848-88042132) |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
5(a) |
possible ortholog |
GroupUn.224(42583-44730) |
ENSEMBL Gene Tree for KLF17 (if available)
TreeFam Gene Tree for KLF17 (if available) |
Paralogs
for KLF17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KLF17 gene
- SP12 SP42 SP32 SP82 SP52 SP62 SP22 SP72
- SP92
18/30 SIMAP similar genes for KLF17 using alignment to 1 protein entry: KLF17_HUMAN(see all similar genes):DKFZp686N0199 ZNF78L1 kr-znf3 DKFZp313F0536 smap-7 zf30
DKFZp686M04222 DKFZp686O1631 ZNF702P ZNF ZFS-6 ZNF323
ZNF833P KLF9 DKFZp434J0650 HZF40 ZFS-2 ZFS-5
KLF17 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for KLF17
PGOHUM00000239489 PGOHUM00000245855
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Genomic Variants
for KLF17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KLF17 (44584522 - 44600812 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KLF17
1 CNV: 4220 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF17 |
|
Disorders
/ Diseases
for KLF17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLF17 for disorders About GeneDecksing
OMIM gene information: 609602
OMIM disorders: --
1  disease for KLF17: About MalaCardsbreast cancer
Export disorders for KLF17 gene to outside databases
|
Publications
for KLF17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLF17 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KLF17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human KLF17 is a new member of the Sp/KLF family of transcription factors. (PubMed id 16460907)1, 2, 3, 9 van Vliet J....Crossley M. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Reduced expression of Kruppel-like factor 17 is relate d to tumor growth and poor prognosis in lung adenocarcinoma. (PubMed id 22240024)1 Cai X.D....Han A.J. (2012)
- KLF17 is a negative regulator of epithelial-mesenchym al transition and metastasis in breast cancer. (PubMed id 19801974)1 Gumireddy K....Huang Q. (2009)
- Transcriptional regulation of metastatic [Id]entity b y KLF17. (PubMed id 19951400)1 Iwanicki M.P. and Brugge J.S. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein. (PubMed id 12351194)1 Yan W....Matzuk M.M. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KLF17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KLF17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLF17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLF17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KLF17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLF17 gene:
Search GeneIP for patents involving KLF17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KLF17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLF17 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF17 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF17 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF17 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF17 |
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