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KLF16 Gene

protein-coding   GIFtS: 50
GCID: GC19M001852

Kruppel-Like Factor 16

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kruppel-Like Factor 161 2     NSLP22 3
Basic Transcription Element-Binding Protein 42 3     BTE-Binding Protein 42 3
Novel Sp1-Like Zinc Finger Transcription Factor 22 3     DRRF2
Transcription Factor BTEB42 3     Basic Transcription Element Binding Protein 42
Transcription Factor NSLP22 3     Dopamine Receptor Regulating Factor2
BTEB42 3     Krueppel-Like Factor 162

External Ids:    HGNC: 168571   Entrez Gene: 838552   Ensembl: ENSG000001299117   OMIM: 6061395   UniProtKB: Q9BXK13   

Export aliases for KLF16 gene to outside databases

Previous GC identifers: GC19M001914 GC19M001792 GC19M001803 GC19M001625


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLF16 Gene:
KLF16 (Kruppel-like factor 16) is a protein-coding gene. Diseases associated with KLF16 include hypoxia, and neuroblastoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1
Function: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences.
Modulates dopaminergic transmission in the brain (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF16 gene promoter:
         STAT5B   AhR   AP-1   HTF   ATF-2   Olf-1   CREB   Ik-2   deltaCREB   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for KLF16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

KLF16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF16 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001852:  view genomic region     (about GC identifiers)

Start:
1,852,398 bp from pter      End:
1,863,567 bp from pter
Size:
11,170 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1 (See protein sequence)
Recommended Name: Krueppel-like factor 16  
Size: 252 amino acids; 25431 Da

Explore the universe of human proteins at neXtProt for KLF16: NX_Q9BXK1

Explore proteomics data for KLF16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLF16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114124.1  
    ENSEMBL proteins: 
     ENSP00000439973   ENSP00000250916  

    KLF16 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for KLF16


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BXK1

    ProtoNet protein and cluster: Q9BXK1

    UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    KLF16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF16_HUMAN, Q9BXK1
    Function: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences.
    Modulates dopaminergic transmission in the brain (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046872metal ion binding IEA--
         
    KLF16 for ontologies           About GeneDecksing


    Animal Models:
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    Selected qRT-PCR Assays for microRNAs that regulate KLF16 (see all 23):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-219-5p hsa-miR-3138 hsa-miR-4267 hsa-miR-124 hsa-miR-125b hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF16 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF16_HUMAN, Q9BXK1: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    KLF16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLF16
    Interactions:

        Search GeneGlobe Interaction Network for KLF16

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KLF16 (Q9BXK13 ENSP000002509164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIN3AQ96ST33, ENSP000003536224I2D: score=2 STRING: ENSP00000353622
    EP300ENSP000002632534STRING: ENSP00000263253
    SIN3BENSP000003691314STRING: ENSP00000369131
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007212dopamine receptor signaling pathway IEA--

    KLF16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLF16 gene: 
    NM_031918.3  

    Unigene Cluster for KLF16:

    Kruppel-like factor 16
    Hs.136280  [show with all ESTs]
    Unigene Representative Sequence: NM_031918
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541015 ENST00000250916(uc002luc.3) ENST00000592313
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KLF16 (see all 23):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-219-5p hsa-miR-3138 hsa-miR-4267 hsa-miR-124 hsa-miR-125b hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF16 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat KLF16
      QuantiFast Probe-based Assays in human, mouse, rat KLF16

    Additional mRNA sequence: 

    AF327440.1 AK025941.1 

    2 DOTS entries:

    DT.95079083  DT.99937905 

    Selected AceView cDNA sequences (see all 112):

    BG109217 BE743310 CA425024 AI739403 CB156455 AI344138 NM_031918 AI936150 
    BF590630 BM557908 AF327440 BM551891 AI270127 BQ447922 BF026754 AI365453 
    CN480385 AW136520 BG116652 BE464096 BF590804 BQ637074 BG104166 BM893612 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGACCCAG
    KLF16 Expression
    About this image


    KLF16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebral Cortex
    KLF16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.136280
        Custom PCR Arrays for KLF16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLF16 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf165 Kruppel-like factor 16   --   10 (39.72 cM) 80567124 
    zebrafish
    (Danio rerio)
    Actinopterygii KLF166
    Kruppel-like factor 16
    43(a)
    1 → many
    2(6943373-6951672) ENSDARG00000069342


    ENSEMBL Gene Tree for KLF16 (if available)
    TreeFam Gene Tree for KLF16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF16 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  
    SP22  KLF102  KLF42  SP12  KLF122  KLF32  KLF92  SP72  
    SP92  
    Selected SIMAP similar genes for KLF16 using alignment to 2 protein entries:     KLF16_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    DKFZp686O1631    ZNF697    KLF6    KLF13    SP2
    ZNF845    WT1    ZFS-5    kr-znf3    KLF7    ZNF304
    ZSCAN10    ZNF78L1    KLF9    ZNF    DKFZp686M04222    DKFZp434J0650

    KLF16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF16 (see all 226)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118809251,2
    C,A,H--1852078(+) GCGCCG/CTGTCA 1 -- int18Minor allele frequency- C:0.28NA WA CSA EA 251
    rs1494099061,2
    C--1852245(+) GCCAGA/TGGGGC 1 -- int10--------
    rs1122213261,2
    C,F--1852373(+) GCCACG/AGGAGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs37460381,2
    C,F,A,H--1852494(+) CCTCTC/TGGAGC 1 -- ut31 ese39Minor allele frequency- T:0.45EA NS NA WA CSA 1963
    rs10549721,2
    C,F--1852582(-) GGGCTT/CGGAGA 1 -- ut319Minor allele frequency- C:0.46EA NA WA CSA 1666
    rs37460401,2
    C,F--1852649(+) CCCTGC/TTCCAG 1 -- ut311Minor allele frequency- T:0.01EA 1488
    rs37460411,2
    C,F,H--1852692(+) ACTCAC/G/TAAAGG 2 -- ut319EA NS NA CSA 2011
    rs1140289411,2
    C,F--1852824(+) CCCTCC/TGAGCC 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs37460421,2
    C,F--1852837(+) GCTCCA/GGAAGG 1 -- ut315Minor allele frequency- G:0.33NA WA EA 362
    rs747625591,2
    C,F--1852914(+) GGGTCC/TAGGTG 1 -- ut311Minor allele frequency- T:0.04EA 120

    HapMap Linkage Disequilibrium report for KLF16 (1852398 - 1863567 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KLF16 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669985CNV Deletion23128226
    esv2660894CNV Deletion23128226
    nsv470107CNV Loss18288195
    dgv3614n71CNV Loss21882294
    nsv910499CNV Loss21882294
    dgv3609n71CNV Loss21882294
    esv25510CNV Loss19812545
    dgv3613n71CNV Loss21882294
    dgv3615n71CNV Loss21882294
    dgv3617n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing KLF16
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606139    OMIM disorders: --

    4 diseases for KLF16:    
    About MalaCards
    hypoxia    neuroblastoma    astrocytoma    cerebritis


    KLF16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLF16
    Human Genome Epidemiology (HuGE) Navigator: KLF16 (3 documents)

    Export disorders for KLF16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF16 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with KLF16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PubMed id 17688680)1, 4 GutiAcrrez-Aguilar R....Neve B. (BMC Med. Genet. 2007)
    2. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (Diabetologia 2005)
    3. A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. (PubMed id 11438660)1, 3 Zhang J.S....Urrutia R. (Mol. Cell. Biol. 2001)
    4. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. (PubMed id 12036432)1, 9 Kaczynski J.A....Urrutia R. (Biochem. J. 2002)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Detailed structural-functional analysis of the KrA1ppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology. (PubMed id 22203677)1 Daftary G.S....Urrutia R. (J. Biol. Chem. 2012)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (J. Proteome Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83855 HGNC: 16857 AceView: KLF16 Ensembl:ENSG00000129911 euGenes: HUgn83855
    ECgene: KLF16 H-InvDB: KLF16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLF16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLF16 gene:
    Search GeneIP for patents involving KLF16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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