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Aliases for KLF16 Gene

Aliases for KLF16 Gene

  • Kruppel-Like Factor 16 2 3 5
  • Novel Sp1-Like Zinc Finger Transcription Factor 2 3 4
  • Basic Transcription Element-Binding Protein 4 3 4
  • Transcription Factor BTEB4 3 4
  • Transcription Factor NSLP2 3 4
  • BTE-Binding Protein 4 3 4
  • BTEB4 3 4
  • NSLP2 3 4
  • Basic Transcription Element Binding Protein 4 3
  • Dopamine Receptor Regulating Factor 3
  • DRRF 3

External Ids for KLF16 Gene

Previous GeneCards Identifiers for KLF16 Gene

  • GC19M001914
  • GC19M001792
  • GC19M001803
  • GC19M001625

Summaries for KLF16 Gene

GeneCards Summary for KLF16 Gene

KLF16 (Kruppel-Like Factor 16) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SP4.

UniProtKB/Swiss-Prot for KLF16 Gene

  • Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF16 Gene

Genomics for KLF16 Gene

Regulatory Elements for KLF16 Gene

Promoters for KLF16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLF16 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF16 Gene

Chromosome:
19
Start:
1,852,399 bp from pter
End:
1,863,568 bp from pter
Size:
11,170 bases
Orientation:
Minus strand

Genomic View for KLF16 Gene

Genes around KLF16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF16 Gene

Proteins for KLF16 Gene

  • Protein details for KLF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXK1-KLF16_HUMAN
    Recommended name:
    Krueppel-like factor 16
    Protein Accession:
    Q9BXK1

    Protein attributes for KLF16 Gene

    Size:
    252 amino acids
    Molecular mass:
    25431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF16 Gene

Proteomics data for KLF16 Gene at MOPED

Post-translational modifications for KLF16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF16 Gene

Antibody Products

No data available for DME Specific Peptides for KLF16 Gene

Domains & Families for KLF16 Gene

Protein Domains for KLF16 Gene

Suggested Antigen Peptide Sequences for KLF16 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BXK1

UniProtKB/Swiss-Prot:

KLF16_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF16: view

Function for KLF16 Gene

Molecular function for KLF16 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).

Gene Ontology (GO) - Molecular Function for KLF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KLF16: view
genes like me logo Genes that share phenotypes with KLF16: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLF16 Gene

Localization for KLF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF16 Gene COMPARTMENTS Subcellular localization image for KLF16 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for KLF16 Gene

Pathways & Interactions for KLF16 Gene

SuperPathways for KLF16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007212 dopamine receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with KLF16: view

No data available for Pathways by source and SIGNOR curated interactions for KLF16 Gene

Drugs & Compounds for KLF16 Gene

No Compound Related Data Available

Transcripts for KLF16 Gene

mRNA/cDNA for KLF16 Gene

Unigene Clusters for KLF16 Gene

Kruppel-like factor 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF16 Gene

No ASD Table

Relevant External Links for KLF16 Gene

GeneLoc Exon Structure for
KLF16
ECgene alternative splicing isoforms for
KLF16

Expression for KLF16 Gene

mRNA expression in normal human tissues for KLF16 Gene

Protein differential expression in normal tissues from HIPED for KLF16 Gene

This gene is overexpressed in Breast (61.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLF16 Gene



SOURCE GeneReport for Unigene cluster for KLF16 Gene Hs.136280

genes like me logo Genes that share expression patterns with KLF16: view

Protein tissue co-expression partners for KLF16 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLF16 Gene

Orthologs for KLF16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100608089 35
  • 97.84 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia KLF16 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf16 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii KLF16 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta EP2237 37
  • 67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWI5 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 36
  • 14 (a)
OneToMany
Species with no ortholog for KLF16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF16 Gene

ENSEMBL:
Gene Tree for KLF16 (if available)
TreeFam:
Gene Tree for KLF16 (if available)

Paralogs for KLF16 Gene

Paralogs for KLF16 Gene

genes like me logo Genes that share paralogs with KLF16: view

Variants for KLF16 Gene

Sequence variations from dbSNP and Humsavar for KLF16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11084912 -- 1,859,391(+) CCTCG(A/C)TCCCT intron-variant
rs8112336 -- 1,862,103(+) CCCCC(A/C)CCCTC intron-variant
rs7254987 -- 1,858,211(+) CCCCA(C/T)CCTGC intron-variant
rs10413786 -- 1,857,491(+) CAGGA(C/T)AGCCT intron-variant
rs8113064 -- 1,862,747(+) CCAGA(A/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF16 Gene

Variant ID Type Subtype PubMed ID
dgv3583n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
nsv910545 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
dgv3615n71 CNV Loss 21882294
dgv3616n71 CNV Loss 21882294
nsv910566 CNV Gain+Loss 21882294
dgv3617n71 CNV Loss 21882294
nsv910569 CNV Loss 21882294
dgv3618n71 CNV Loss 21882294
dgv3619n71 CNV Loss 21882294
dgv3620n71 CNV Loss 21882294
nsv910579 CNV Gain 21882294
esv2669985 CNV Deletion 23128226
esv2660894 CNV Deletion 23128226
nsv910586 CNV Loss 21882294
nsv910587 CNV Gain+Loss 21882294
esv2646506 CNV Loss 19546169
esv25510 CNV Loss 19812545

Variation tolerance for KLF16 Gene

Gene Damage Index Score: 3.09; 50.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF16 Gene

HapMap Linkage Disequilibrium report
KLF16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF16 Gene

Disorders for KLF16 Gene

Relevant External Links for KLF16

Genetic Association Database (GAD)
KLF16
Human Genome Epidemiology (HuGE) Navigator
KLF16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF16

No disorders were found for KLF16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF16 Gene

Publications for KLF16 Gene

  1. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PMID: 17688680) GutiAcrrez-Aguilar R. … Neve B. (BMC Med. Genet. 2007) 3 48 67
  2. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. (PMID: 12036432) Kaczynski J.A. … Urrutia R. (Biochem. J. 2002) 3 23
  3. A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. (PMID: 11438660) Zhang J.S. … Urrutia R. (Mol. Cell. Biol. 2001) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for KLF16 Gene

Sources for KLF16 Gene

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