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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLF16 Gene

protein-coding   GIFtS: 50
GCID: GC19M001852

Kruppel-like factor 16

 Explore 3 diseases affiliated with
KLF16 via our new
 Human Malady Compendium 
Biological research products
for KLF16
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Kruppel-Like Factor 161 2     Transcription Factor BTEB42 3
BTEB41 2 3     Transcription Factor NSLP22 3
NSLP21 2 3     BTE-Binding Protein 42 3
DRRF1 2     Basic Transcription Element Binding Protein 42
Basic Transcription Element-Binding Protein 42 3     Dopamine Receptor Regulating Factor2
Novel Sp1-Like Zinc Finger Transcription Factor 22 3     Krueppel-Like Factor 162

External Ids:    HGNC: 168571   Entrez Gene: 838552   Ensembl: ENSG000001299117   OMIM: 6061395   UniProtKB: Q9BXK13   

Export aliases for KLF16 gene to outside databases

Previous GC identifers: GC19M001914 GC19M001792 GC19M001803 GC19M001625


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1
Function: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates
dopaminergic transmission in the brain (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLF16 gene promoter:
         STAT5B   AhR   AP-1   HTF   ATF-2   Olf-1   CREB   Ik-2   deltaCREB   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KLF16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

KLF16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF16 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001852:  view genomic region     (about GC identifiers)

Start:
1,852,398 bp from pter      End:
1,863,567 bp from pter
Size:
11,170 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1 (See protein sequence)
Recommended Name: Krueppel-like factor 16  
Size: 252 amino acids; 25431 Da
Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for KLF16: NX_Q9BXK1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BXK1

  • KLF16 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_114124.1  
    ENSEMBL proteins: 
     ENSP00000439973   ENSP00000250916  

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    Uscn Proteins for KLF16

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    KLF16 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    KLF16 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BXK1

    ProtoNet protein and cluster: Q9BXK1

    UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1
    Function: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates
    dopaminergic transmission in the brain (By similarity)

    miRNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--


    KLF16 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLF16

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KLF16 (Q9BXK13 ENSP000002509164) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIN3AQ96ST33, ENSP000003536224I2D: score=2 STRING: ENSP00000353622
    EP300ENSP000002632534STRING: ENSP00000263253
    SIN3BENSP000003691314STRING: ENSP00000369131
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007212dopamine receptor signaling pathway IEA--


    KLF16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLF16
    Search CenterWatch for drugs/clinical trials and news about KLF16 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLF16 gene: 
    NM_031918.3  

    Unigene Cluster for KLF16:

    Kruppel-like factor 16
    Hs.136280  [show with all ESTs]
    Unigene Representative Sequence: NM_031918
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541015 ENST00000250916(uc002luc.3) ENST00000592313

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF16 (see all 23):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-219-5p hsa-miR-3138 hsa-miR-4267 hsa-miR-124 hsa-miR-125b hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidKLF16 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF16

    Additional cDNA sequence: 

    AF327440.1 AK025941.1 

    2 DOTS entries:

    DT.95079083  DT.99937905 

    24/112 AceView cDNA sequences (see all 112):

    BQ447922 BF590630 CB156455 BG109217 BM551891 AF327440 AI365453 BM557908 
    AI344138 BF026754 AW136520 AI270127 CN480385 AI936150 BE743310 AI739403 
    CA425024 NM_031918 AI739110 BE464096 AA397538 AA936100 CK823272 AI669108 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLF16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAGACCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See KLF16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLF16

    SOURCE GeneReport for Unigene cluster: Hs.136280
        SABiosciences Custom PCR Arrays for KLF16
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLF16 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    2(a)
    possible ortholog
    3(88021848-88042132)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1531151 zgc:153115 63.08(n)
    60.77(a)
      768186  NM_001077329.1  NP_001070797.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    5(a)
    possible ortholog
    GroupUn.224(42583-44730)
    worm
    (Caenorhabditis elegans)
    Secernentea sptf-16
    Specificity Protein) Transcription Factor family m...
    10(a)
    possible ortholog
    I(10366612-10371685)


    ENSEMBL Gene Tree for KLF16 (if available)
    TreeFam Gene Tree for KLF16 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLF16 gene
    KLF12  KLF112  KLF62  KLF102  KLF42  KLF52  KLF142  KLF22  
    KLF152  KLF92  KLF122  KLF32  KLF72  KLF132  KLF82  
    18/52 SIMAP similar genes for KLF16 using alignment to 2 protein entries:     KLF16_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0199    DKFZp686O1631    ZNF697    KLF6    KLF13    SP2
    ZNF845    WT1    ZFS-5    kr-znf3    DKFZp313F0536    KLF7
    ZNF304    ZSCAN10    ZNF78L1    KLF9    ZNF    DKFZp686M04222

    KLF16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/172 NCBI SNPs in KLF16 are shown (see all 172    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118809251,2
    C,A,H,--1852078(+) GCGCCG/CTGTCA 1 -- int18Minor allele frequency- C:0.28NA WA CSA EA 251
    rs1494099061,2
    --1852245(+) GCCAGA/TGGGGC 1 -- int10--------
    rs1122213261,2
    C,--1852373(+) GCCACG/AGGAGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs37460381,2
    C,F,A,H,--1852494(+) CCTCTC/TGGAGC 1 -- ut31 ese39Minor allele frequency- T:0.45EA NS NA WA CSA 1963
    rs10549721,2
    C,F,--1852582(-) GGGCTT/CGGAGA 1 -- ut319Minor allele frequency- C:0.46EA NA WA CSA 1666
    rs37460401,2
    C,F,--1852649(+) CCCTGC/TTCCAG 1 -- ut311Minor allele frequency- T:0.01EA 1488
    rs37460411,2
    C,F,H,--1852692(+) ACTCAC/G/TAAAGG 2 -- ut319EA NS NA CSA 2011
    rs1140289411,2
    C,F,--1852824(+) CCCTCC/TGAGCC 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs37460421,2
    C,F,--1852837(+) GCTCCA/GGAAGG 1 -- ut315Minor allele frequency- G:0.33NA WA EA 362
    rs747625591,2
    F,--1852914(+) GGGTCC/TAGGTG 1 -- ut311Minor allele frequency- T:0.04EA 120

    HapMap Linkage Disequilibrium report for KLF16 (1852398 - 1863567 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for KLF16
         5 CNVs: 30062 30061 73277 102764 7191

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KLF16 for disorders           About GeneDecksing

    OMIM gene information: 606139    OMIM disorders: --

    3 diseases for KLF16:    About MalaCards
    astrocytoma    hypoxia    neuroblastoma

    Genetic Association Database (GAD): KLF16
    Human Genome Epidemiology (HuGE) Navigator: KLF16 (3 documents)

    Export disorders for KLF16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLF16 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with KLF16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (2005)
    2. A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. (PubMed id 11438660)1, 3 Zhang J.S....Urrutia R. (2001)
    3. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. (PubMed id 12036432)1, 9 Kaczynski J.A....Urrutia R. (2002)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Detailed structural-functional analysis of the Kruppel -like factor 16 (KLF16) transcription factor reveals novel mechanisms for silenc ing Sp/KLF sites involved in metabolism and endocrinology. (PubMed id 22203677)1 Daftary G.S....Urrutia R. (2012)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. (PubMed id 17480121)1 Parker-Katiraee L....Scherer S.W. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83855 HGNC: 16857 AceView: KLF16 Ensembl:ENSG00000129911 euGenes: HUgn83855
    ECgene: KLF16 H-InvDB: KLF16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLF16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLF16 gene:
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