Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KLF16 Gene

Aliases for KLF16 Gene

  • Kruppel-Like Factor 16 2 3
  • Novel Sp1-Like Zinc Finger Transcription Factor 2 3 4
  • Basic Transcription Element-Binding Protein 4 3 4
  • Transcription Factor BTEB4 3 4
  • Transcription Factor NSLP2 3 4
  • BTE-Binding Protein 4 3 4
  • BTEB4 3 4
  • NSLP2 3 4
  • Basic Transcription Element Binding Protein 4 3
  • Dopamine Receptor Regulating Factor 3
  • Krueppel-Like Factor 16 3
  • DRRF 3

External Ids for KLF16 Gene

Previous GeneCards Identifiers for KLF16 Gene

  • GC19M001914
  • GC19M001792
  • GC19M001803
  • GC19M001625

Summaries for KLF16 Gene

GeneCards Summary for KLF16 Gene

KLF16 (Kruppel-Like Factor 16) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for KLF16 Gene

  • Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF16 Gene

Genomics for KLF16 Gene

Regulatory Elements for KLF16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLF16 Gene

1,852,399 bp from pter
1,863,568 bp from pter
11,170 bases
Minus strand

Genomic View for KLF16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF16 Gene

Proteins for KLF16 Gene

  • Protein details for KLF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Krueppel-like factor 16
    Protein Accession:
    Secondary Accessions:

    Protein attributes for KLF16 Gene

    252 amino acids
    Molecular mass:
    25431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF16 Gene

Proteomics data for KLF16 Gene at MOPED

Post-translational modifications for KLF16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF16 Gene

No data available for DME Specific Peptides for KLF16 Gene

Domains for KLF16 Gene

Gene Families for KLF16 Gene

  • KLF :Kruppel-like transcription factors
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for KLF16 Gene

Suggested Antigen Peptide Sequences for KLF16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BXK1
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF16: view

Function for KLF16 Gene

Molecular function for KLF16 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).

Gene Ontology (GO) - Molecular Function for KLF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF16: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KLF16 Gene

Localization for KLF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF16 Gene

Subcellular locations from

Jensen Localization Image for KLF16 Gene COMPARTMENTS Subcellular localization image for KLF16 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for KLF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF16: view

Pathways for KLF16 Gene

SuperPathways for KLF16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007212 dopamine receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with KLF16: view

No data available for Pathways by source for KLF16 Gene

Transcripts for KLF16 Gene

mRNA/cDNA for KLF16 Gene

Unigene Clusters for KLF16 Gene

Kruppel-like factor 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLF16

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KLF16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF16 Gene

No ASD Table

Relevant External Links for KLF16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLF16 Gene

mRNA expression in normal human tissues for KLF16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLF16 Gene

SOURCE GeneReport for Unigene cluster for KLF16 Gene Hs.136280

genes like me logo Genes that share expressions with KLF16: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLF16 Gene

Orthologs for KLF16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100608089 35
  • 97.84 (n)
  • 100 (a)
(Bos Taurus)
Mammalia KLF16 36
  • 81 (a)
(Mus musculus)
Mammalia Klf16 16
Klf16 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
(Danio rerio)
Actinopterygii KLF16 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta EP2237 37
  • 67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWI5 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 36
  • 14 (a)
Species with no ortholog for KLF16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF16 Gene

Gene Tree for KLF16 (if available)
Gene Tree for KLF16 (if available)

Paralogs for KLF16 Gene

genes like me logo Genes that share paralogs with KLF16: view

Variants for KLF16 Gene

Sequence variations from dbSNP and Humsavar for KLF16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs893541 -- 1,858,184(+) TCCCA(C/T)CACCT intron-variant
rs1054972 -- 1,852,583(-) GGGCT(C/T)GGAGA utr-variant-3-prime
rs3746038 -- 1,852,495(+) CCTCT(C/T)GGAGC utr-variant-3-prime
rs3746040 -- 1,852,650(+) CCCTG(C/T)TCCAG utr-variant-3-prime
rs3746041 -- 1,852,693(+) ACTCA(C/G/T)AAAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KLF16 Gene

Variant ID Type Subtype PubMed ID
dgv3583n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
nsv910545 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
dgv3615n71 CNV Loss 21882294
dgv3616n71 CNV Loss 21882294
nsv910566 CNV Gain+Loss 21882294
dgv3617n71 CNV Loss 21882294
nsv910569 CNV Loss 21882294
dgv3618n71 CNV Loss 21882294
dgv3619n71 CNV Loss 21882294
dgv3620n71 CNV Loss 21882294
nsv910579 CNV Gain 21882294
esv2669985 CNV Deletion 23128226
esv2660894 CNV Deletion 23128226
nsv910586 CNV Loss 21882294
nsv910587 CNV Gain+Loss 21882294
esv2646506 CNV Loss 19546169
esv25510 CNV Loss 19812545

Relevant External Links for KLF16 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF16 Gene

Disorders for KLF16 Gene

Relevant External Links for KLF16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with KLF16: view

No data available for UniProtKB/Swiss-Prot for KLF16 Gene

Publications for KLF16 Gene

  1. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PMID: 17688680) GutiAcrrez-Aguilar R. … Neve B. (BMC Med. Genet. 2007) 3 48
  2. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. (PMID: 12036432) Kaczynski J.A. … Urrutia R. (Biochem. J. 2002) 3 23
  3. A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. (PMID: 11438660) Zhang J.S. … Urrutia R. (Mol. Cell. Biol. 2001) 2 3
  4. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PMID: 15937668) Kanazawa A. … Maeda S. (Diabetologia 2005) 3 48
  5. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. (PMID: 17480121) Parker-Katiraee L. … Scherer S.W. (PLoS Genet. 2007) 3

Products for KLF16 Gene

Sources for KLF16 Gene

Back to Top