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Aliases for KLF16 Gene

Aliases for KLF16 Gene

  • Kruppel Like Factor 16 2 3 5
  • Novel Sp1-Like Zinc Finger Transcription Factor 2 3 4
  • Transcription Factor BTEB4 3 4
  • Transcription Factor NSLP2 3 4
  • BTE-Binding Protein 4 3 4
  • BTEB4 3 4
  • NSLP2 3 4
  • Basic Transcription Element Binding Protein 4 3
  • Basic Transcription Element-Binding Protein 4 4
  • Dopamine Receptor Regulating Factor 3
  • Krueppel-Like Factor 16 3
  • Unknown Transcript 3
  • DRRF 3

External Ids for KLF16 Gene

Previous GeneCards Identifiers for KLF16 Gene

  • GC19M001914
  • GC19M001792
  • GC19M001803
  • GC19M001625

Summaries for KLF16 Gene

GeneCards Summary for KLF16 Gene

KLF16 (Kruppel Like Factor 16) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity. An important paralog of this gene is KLF14.

UniProtKB/Swiss-Prot for KLF16 Gene

  • Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).

Additional gene information for KLF16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF16 Gene

Genomics for KLF16 Gene

GeneHancer (GH) Regulatory Elements for KLF16 Gene

Promoters and enhancers for KLF16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I001851 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562 +5.1 5094 14.9 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 ZNF610 KLF16 GC19M001854 ENSG00000267141 SF3A2 ATP8B3 DAZAP1 ZNF555 LOC100288123 REXO1 ELOCP28
GH19I001939 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.5 -78.4 -78449 5.4 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 CSNK1G2 LOC105372238 KLF16 ZNF555 SF3A2 BTBD2 CSNK1G2-AS1 PEAK3 ENSG00000267283 REXO1
GH19I001895 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -33.3 -33268 3.7 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 KLF16 LOC100288123 DOT1L CSNK1G2 OAZ1 SCAMP4 ABHD17A
GH19I001835 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.6 +26.4 26436 2.8 HDGF ATF1 ARNT TCF12 ZNF766 GLIS2 GATA2 ZNF143 ATF7 RXRA KLF16 ATP8B3 TCF3 RNU6-1223P LOC100288123 REXO1
GH19I002064 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -202.5 -202539 4.2 DRAP1 TFAP4 MXI1 ZNF792 SAP130 ZNF133 ARID4B ZNF384 RARA ZNF664 BTBD2 KLF16 MOB3A MKNK2 GC19M002058 GC19P002080
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KLF16 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KLF16 gene promoter:

Genomic Locations for KLF16 Gene

Genomic Locations for KLF16 Gene
11,170 bases
Minus strand

Genomic View for KLF16 Gene

Genes around KLF16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF16 Gene

Proteins for KLF16 Gene

  • Protein details for KLF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Krueppel-like factor 16
    Protein Accession:

    Protein attributes for KLF16 Gene

    252 amino acids
    Molecular mass:
    25431 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF16 Gene

Post-translational modifications for KLF16 Gene

No Post-translational modifications

Other Protein References for KLF16 Gene

No data available for DME Specific Peptides for KLF16 Gene

Domains & Families for KLF16 Gene

Gene Families for KLF16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for KLF16 Gene

Suggested Antigen Peptide Sequences for KLF16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF16: view

Function for KLF16 Gene

Molecular function for KLF16 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity).

Phenotypes From GWAS Catalog for KLF16 Gene

Gene Ontology (GO) - Molecular Function for KLF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with KLF16: view
genes like me logo Genes that share phenotypes with KLF16: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLF16 Gene

Localization for KLF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF16 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KLF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF16: view

Pathways & Interactions for KLF16 Gene

SuperPathways for KLF16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007212 dopamine receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with KLF16: view

No data available for Pathways by source and SIGNOR curated interactions for KLF16 Gene

Drugs & Compounds for KLF16 Gene

No Compound Related Data Available

Transcripts for KLF16 Gene

mRNA/cDNA for KLF16 Gene

Unigene Clusters for KLF16 Gene

Kruppel-like factor 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF16 Gene

No ASD Table

Relevant External Links for KLF16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLF16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF16 Gene

Protein differential expression in normal tissues from HIPED for KLF16 Gene

This gene is overexpressed in Breast (61.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLF16 Gene

Protein tissue co-expression partners for KLF16 Gene

NURSA nuclear receptor signaling pathways regulating expression of KLF16 Gene:


SOURCE GeneReport for Unigene cluster for KLF16 Gene:


Evidence on tissue expression from TISSUES for KLF16 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with KLF16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF16 Gene

Orthologs for KLF16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KLF16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100608089 33
  • 97.84 (n)
(Mus musculus)
Mammalia Klf16 34
  • 88 (a)
(Bos Taurus)
Mammalia KLF16 34
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
(Danio rerio)
Actinopterygii KLF16 34
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta EP2237 35
  • 67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWI5 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 34
  • 14 (a)
Species where no ortholog for KLF16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF16 Gene

Gene Tree for KLF16 (if available)
Gene Tree for KLF16 (if available)

Paralogs for KLF16 Gene

Variants for KLF16 Gene

Sequence variations from dbSNP and Humsavar for KLF16 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000034171 -- 1,852,597(-) T/C 3_prime_UTR_variant
rs1000063782 -- 1,854,368(-) G/A 3_prime_UTR_variant
rs1000090858 -- 1,862,780(-) T/A intron_variant
rs1000123317 -- 1,859,177(-) C/T intron_variant
rs1000259883 -- 1,865,484(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KLF16 Gene

Variant ID Type Subtype PubMed ID
dgv6210n54 CNV gain 21841781
dgv6211n54 CNV gain 21841781
esv25510 CNV loss 19812545
esv2646506 CNV loss 19546169
esv2660894 CNV deletion 23128226
esv2669985 CNV deletion 23128226
esv32942 CNV gain+loss 17666407
esv3893156 CNV loss 25118596
nsv1071491 CNV deletion 25765185
nsv1160560 CNV deletion 26073780
nsv470107 CNV loss 18288195
nsv578337 CNV gain 21841781
nsv578338 CNV loss 21841781
nsv578339 CNV loss 21841781
nsv578340 CNV gain 21841781
nsv578341 CNV gain+loss 21841781
nsv578345 CNV gain 21841781
nsv578346 CNV loss 21841781
nsv953942 CNV deletion 24416366

Variation tolerance for KLF16 Gene

Gene Damage Index Score: 3.09; 50.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KLF16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF16 Gene

Disorders for KLF16 Gene

Additional Disease Information for KLF16

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KLF16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF16 Gene

Publications for KLF16 Gene

  1. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PMID: 17688680) Gutiérrez-Aguilar R … Neve B (BMC medical genetics 2007) 3 44 58
  2. Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes. (PMID: 15937668) Kanazawa A … Maeda S (Diabetologia 2005) 3 44 58
  3. Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. (PMID: 12036432) Kaczynski JA … Urrutia R (The Biochemical journal 2002) 3 22 58
  4. A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. (PMID: 11438660) Zhang JS … Urrutia R (Molecular and cellular biology 2001) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for KLF16 Gene

Sources for KLF16 Gene

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