KLF16 Gene
protein-coding GIFtS: 50
GCID: GC19M001852
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Kruppel-like factor 16
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Aliases for KLF16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Kruppel-Like Factor 161 2 | | Transcription Factor BTEB42 3 | | BTEB41 2 3 | | Transcription Factor NSLP22 3 | | NSLP21 2 3 | | BTE-Binding Protein 42 3 | | DRRF1 2 | | Basic Transcription Element Binding Protein 42 | | Basic Transcription Element-Binding Protein 42 3 | | Dopamine Receptor Regulating Factor2 | | Novel Sp1-Like Zinc Finger Transcription Factor 22 3 | | Krueppel-Like Factor 162 |
Export aliases for KLF16 gene to outside databasesPrevious GC identifers: GC19M001914 GC19M001792 GC19M001803 GC19M001625 |
Summaries for KLF16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1Function: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulatesdopaminergic transmission in the brain (By similarity)
|
Genomic Views for KLF16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KLF16 gene promoter: STAT5B AhR AP-1 HTF ATF-2 Olf-1 CREB Ik-2 deltaCREB c-Jun Other transcription factors
Search SABiosciences Chromatin IP Primers for KLF16
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF16 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3KLF16 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M001852: view genomic region
(about GC identifiers)
Start:
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1,852,398 bp from pter |
End:
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1,863,567 bp from pter |
Size:
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11,170 bases |
Orientation:
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minus strand |
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Proteins for KLF16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1 (See
protein sequence)Recommended Name: Krueppel-like factor 16 Size: 252 amino acids; 25431 Da
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for KLF16: NX_Q9BXK1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXK1 KLF16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114124.1 ENSEMBL proteins: ENSP00000439973 ENSP00000250916 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
KLF16 for ontologies About GeneDecksing
KLF16 Antibody Products: Assay Products for KLF16: |
Protein
Domains / Families for KLF16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KLF16 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXK1ProtoNet protein and cluster: Q9BXK1 UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein familySimilarity: Contains 3 C2H2-type zinc fingers |
Function for KLF16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: KLF16_HUMAN, Q9BXK1Function: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulatesdopaminergic transmission in the brain (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF16 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF16 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for KLF16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF16  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF16 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
KLF16 for ontologies About GeneDecksing
|
Pathways & Interactions for KLF16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLF16
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
 3 Interacting proteins for KLF16 (Q9BXK13 ENSP000002509164) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0007212 | dopamine receptor signaling pathway |
IEA | -- |
KLF16 for ontologies About GeneDecksing
|
Drugs & Compounds for KLF16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for KLF16 Search CenterWatch for drugs/clinical trials and news about KLF16 
|
Transcripts for KLF16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for KLF16 gene: NM_031918.3 Unigene Cluster for KLF16: Kruppel-like factor 16 Hs.136280 [show with all ESTs]Unigene Representative Sequence: NM_0319183 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000541015 ENST00000250916(uc002luc.3) ENST00000592313
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLF16 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLF16 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KLF16 (NM_031918) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLF16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF16  |
Additional cDNA sequence: AF327440.1 AK025941.1 2 DOTS entries: DT.95079083 DT.99937905 24/112 AceView cDNA sequences (see all 112): BQ447922 BF590630 CB156455 BG109217 BM551891 AF327440 AI365453 BM557908 AI344138 BF026754 AW136520 AI270127 CN480385 AI936150 BE743310 AI739403 CA425024 NM_031918 AI739110 BE464096 AA397538 AA936100 CK823272 AI669108 GeneLoc Exon Structure
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Expression for KLF16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KLF16 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCAGACCCAG
About this image See KLF16 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KLF16
SOURCE GeneReport for Unigene cluster: Hs.136280 SABiosciences Custom PCR Arrays for KLF16
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KLF16 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KLF16 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF16 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF16 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF16 |
Orthologs for KLF16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KLF16 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
-- |
-- |
2(a) |
possible ortholog |
3(88021848-88042132) |
zebrafish (Danio rerio) |
Actinopterygii |
zgc:1531151 |
zgc:153115 |
63.08(n) 60.77(a) |
  |
768186 NM_001077329.1 NP_001070797.1 |
honey bee (Apis mellifera) |
Insecta |
-- |
-- |
5(a) |
possible ortholog |
GroupUn.224(42583-44730) |
worm (Caenorhabditis elegans) |
Secernentea |
sptf-16 |
Specificity Protein) Transcription Factor family m... |
10(a) |
possible ortholog |
I(10366612-10371685) |
ENSEMBL Gene Tree for KLF16 (if available) TreeFam Gene Tree for KLF16 (if available)  |
Paralogs for KLF16 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for KLF16 gene
- KLF12 KLF112 KLF62 KLF102 KLF42 KLF52 KLF142 KLF22
- KLF152 KLF92 KLF122 KLF32 KLF72 KLF132 KLF82
18/52 SIMAP similar genes for KLF16 using alignment to 2 protein entries: KLF16_HUMAN (see all proteins)
(see all similar genes):DKFZp686N0199 DKFZp686O1631 ZNF697 KLF6 KLF13 SP2 ZNF845 WT1 ZFS-5 kr-znf3 DKFZp313F0536 KLF7 ZNF304 ZSCAN10 ZNF78L1 KLF9 ZNF DKFZp686M04222
KLF16 for paralogs About GeneDecksing
|
Genomic Variants for KLF16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 19 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for KLF16 (1852398 - 1863567 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 5 variations for KLF16 5 CNVs: 30062 30061 73277 102764 7191  | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for KLF16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KLF16 for disorders About GeneDecksing
OMIM gene information: 606139
OMIM disorders: --
3 diseases for KLF16: About MalaCardsastrocytoma hypoxia neuroblastoma Genetic Association Database (GAD): KLF16 Human Genome Epidemiology (HuGE) Navigator: KLF16 (3 documents) Export disorders for KLF16 gene to outside databases
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Publications for KLF16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KLF16 gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with KLF16) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (2005)
- A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. (PubMed id 11438660)1, 3 Zhang J.S....Urrutia R. (2001)
- Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. (PubMed id 12036432)1, 9 Kaczynski J.A....Urrutia R. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Detailed structural-functional analysis of the Kruppel -like factor 16 (KLF16) transcription factor reveals novel mechanisms for silenc ing Sp/KLF sites involved in metabolism and endocrinology. (PubMed id 22203677)1 Daftary G.S....Urrutia R. (2012)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. (PubMed id 17480121)1 Parker-Katiraee L....Scherer S.W. (2007)
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External Searches for KLF16 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing KLF16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KLF16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KLF16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for KLF16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KLF16 gene: Search GeneIP for patents involving KLF16
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for KLF16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
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variant library, vector shuttling | | OriGene Custom Antibody Services for KLF16 | | OriGene Custom Protein Services for KLF16 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLF16 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLF16 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF16 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF16 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF16 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF16 |
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| | | Search Tocris compounds for KLF16 |
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 | | KLF16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF16 |
|  |  |  | | | ThermoFisher Antibodies for KLF16 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF16 |
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