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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLF15 Gene

protein-coding   GIFtS: 56
GCID: GC03M126061

Kruppel-Like Factor 15

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kruppel-Like Factor 151 2
KKLF2 3 5
Kidney-Enriched Kruppel-Like Factor1 2
Kidney-Enriched Krueppel-Like Factor2 3
Krueppel-Like Factor 152

External Ids:    HGNC: 145361   Entrez Gene: 289992   Ensembl: ENSG000001638847   OMIM: 6064655   UniProtKB: Q9UIH93   

Export aliases for KLF15 gene to outside databases

Previous GC identifers: GC03M122845 GC03M126092 GC03M127343 GC03M127382 GC03M127544 GC03M123442


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLF15 Gene: 
KLF15 (Kruppel-like factor 15) is a protein-coding gene. Diseases associated with KLF15 include aortic aneurysm, and hepatitis b. GO annotations related to this gene include DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF15_HUMAN, Q9UIH9
Function: Transcriptional activator. Binds to the GA element of the CLCNKA promoter

Gene Wiki entry for KLF15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLF15 gene promoter:
         E2F-3a   PPAR-gamma1   Sp1   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF15 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLF15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

KLF15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF15 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M126061:  view genomic region     (about GC identifiers)

Start:
126,061,478 bp from pter      End:
126,076,285 bp from pter
Size:
14,808 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLF15_HUMAN, Q9UIH9 (See protein sequence)
Recommended Name: Krueppel-like factor 15  
Size: 416 amino acids; 43992 Da
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for KLF15:
2ENT (3D)    

Explore the universe of human proteins at neXtProt for KLF15: NX_Q9UIH9

Explore proteomics data for KLF15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UIH9

  • KLF15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLF15 Protein Expression
    REFSEQ proteins: NP_054798.1  
    ENSEMBL proteins: 
     ENSP00000296233  

    Human Recombinant Protein Products for KLF15: 
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    Cloud-Clone Corp. Proteins for KLF15 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA--

    KLF15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UIH9

    ProtoNet protein and cluster: Q9UIH9

    UniProtKB/Swiss-Prot: KLF15_HUMAN, Q9UIH9
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    KLF15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF15_HUMAN, Q9UIH9
    Function: Transcriptional activator. Binds to the GA element of the CLCNKA promoter

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IC19767294
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding ----
    GO:0008270zinc ion binding ----
         
    KLF15 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLF15:
     Decreased viability of wild-ty 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Klf15):
     adipose tissue  cardiovascular system  growth/size  homeostasis/metabolism  liver/biliary system 
     mortality/aging  muscle  renal/urinary system 

    KLF15 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidKLF15 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLF15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Adipogenesis
    Adipogenesis


    1 BioSystems Pathway for KLF15
        Adipogenesis



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLF15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KLF15 (Q9UIH93 ENSP000002962334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT2BQ928313, ENSP000002637544I2D: score=1 STRING: ENSP00000263754
    SNX13ENSP000003987894STRING: ENSP00000398789
    TCF21ENSP000002373164STRING: ENSP00000237316
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010001glial cell differentiation IEA--
    GO:0015758glucose transport IEA--
    GO:0045893positive regulation of transcription, DNA-dependent ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IMP19767294

    KLF15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLF15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLF15

    1 Novoseek inferred chemical compound relationship for KLF15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 33.3 2 10982849 (1)

    Search CenterWatch for drugs/clinical trials and news about KLF15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLF15 gene: 
    NM_014079.3  

    Unigene Cluster for KLF15:

    Kruppel-like factor 15
    Hs.272215  [show with all ESTs]
    Unigene Representative Sequence: BC036733
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296233(uc011bkk.1) ENST00000509675
    miRNA
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    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-376b hsa-miR-4305 hsa-let-7a-2* hsa-miR-632 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidKLF15 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AB029254.1 BC036733.1 BX649049.1 

    1 DOTS entry:

    DT.91750479 

    24/34 AceView cDNA sequences (see all 34):

    AI563981 AI369833 AI859036 AI934736 BX280931 AI360374 BE463683 BE326850 
    BI094007 BC036733 BM787063 BM713855 NM_014079 BU738907 BE783185 AI569813 
    BE552120 AB029254 BE892379 BG820336 BF939596 BG898891 AI823575 BX090722 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KLF15    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
    SP1:              -     -                           
    SP2:                    -                           
    SP3:                                                


    ECgene alternative splicing isoforms for KLF15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLF15 expression in normal human tissues (normalized intensities)      KLF15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTGAGTT
    KLF15 Expression
    About this image


    KLF15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Gut Tube (Gastrointestinal Tract)
             Primitive gut tube-like cells ( A scalable, suspension protocol for derivation of...
     
     Kidney (Urinary System)

    See KLF15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLF15

    SOURCE GeneReport for Unigene cluster: Hs.272215

    UniProtKB/Swiss-Prot: KLF15_HUMAN, Q9UIH9
    Tissue specificity: Highly expressed in liver, followed by heart, skeletal muscle, and kidney. Not expressed in
    bone marrow or lymphoid tissues

        SABiosciences Expression via Pathway-Focused PCR Array including KLF15: 
              Adipogenesis in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLF15 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf151 , 5 Kruppel-like factor 151, 5 83.53(n)1
    85.3(a)1
      6 (40.16 cM)5
    662771  NM_023184.31  NP_075673.11 
     904625765 
    chicken
    (Gallus gallus)
    Aves KLF151 Kruppel-like factor 15 67.58(n)
    69.83(a)
      427588  XM_425161.2  XP_425161.2 
    zebrafish
    (Danio rerio)
    Actinopterygii klf151 Kruppel-like factor 15 61.54(n)
    60(a)
      335901  NM_212746.2  NP_997911.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta EP22373 transcriptional activator 66(a)
    (best of 2)
      21C6   --


    ENSEMBL Gene Tree for KLF15 (if available)
    TreeFam Gene Tree for KLF15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLF15 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF22  KLF72  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    1 SIMAP similar gene for KLF15 using alignment to 1 protein entry:     KLF15_HUMAN:
    KLF7

    KLF15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/342 SNPs in KLF15 are shown (see all 342)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391267301,2
    --126061079(+) CCAAGA/GCACAG 1 -- int10--------
    rs604352101,2
    F--126061119(+) GGTGGA/GCTGGA 1 -- int11Minor allele frequency- G:0.10WA 118
    rs1866328441,2
    --126061155(+) TCTCCA/GATAGC 1 -- int10--------
    rs1441370651,2
    --126061177(+) GCCTCA/GCAGGA 1 -- int10--------
    rs1460364531,2
    --126061245(+) GTTTAC/TGGAGC 1 -- int10--------
    rs1925628851,2
    --126061332(+) TGGACC/GGGGGC 1 -- int10--------
    rs1854400991,2
    --126061333(+) GGACCA/GGGGCT 1 -- int10--------
    rs1486551851,2
    --126061406(+) GTGGAG/TACATA 1 -- int10--------
    rs1421714161,2
    --126061684(+) GAAATA/GAACCT 1 -- ut310--------
    rs1398830451,2
    C--126061761(+) TGGGA-/GGCTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KLF15 (126061478 - 126076285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KLF15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29660CNV Loss19812545
    dgv5245n71CNV Loss21882294
    nsv877432CNV Loss21882294
    nsv877436CNV Loss21882294
    nsv877433CNV Loss21882294
    nsv877434CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606465    OMIM disorders: --

    4 diseases for KLF15:    About MalaCards
    aortic aneurysm    hepatitis b    hepatitis    endotheliitis


    KLF15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLF15
    Human Genome Epidemiology (HuGE) Navigator: KLF15 (2 documents)

    Export disorders for KLF15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLF15 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with KLF15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor. (PubMed id 10982849)1, 2, 3, 9 Uchida S.... Marumo F. (2000)
    2. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PubMed id 17688680)1, 4 Gutierrez-Aguilar R....Neve B. (2007)
    3. Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. (PubMed id 17438289)1, 9 Fisch S....Jain M.K. (2007)
    6. KLF15 Is a transcriptional regulator of the human 17b eta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulati on of testosterone production and fat stores in women. (PubMed id 19366843)1, 9 Du X....Qin K. (2009)
    7. Genetic variants associated with glycine metabolism an d their role in insulin sensitivity and type 2 diabetes. (PubMed id 23378610)1 Xie W....Walker M. (2013)
    8. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    9. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. (PubMed id 22493257)1 Haldar S.M....Jain M.K. (2012)
    10. Kruppel-like factor 15 (KLF15) is a key regulator of p odocyte differentiation. (PubMed id 22493483)1 Mallipattu S.K....He J.C. (2012)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28999 HGNC: 14536 AceView: KLF15 Ensembl:ENSG00000163884 euGenes: HUgn28999
    ECgene: KLF15 H-InvDB: KLF15

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for KLF15 Pharmacogenomics, SNPs, Pathways

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