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KLF15 Gene

protein-coding   GIFtS: 55
GCID: GC03M126061

Kruppel-Like Factor 15

  Search for KLF15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kruppel-Like Factor 151 2
KKLF2 3 5
Kidney-Enriched Kruppel-Like Factor1 2
Kidney-Enriched Krueppel-Like Factor2 3
Krueppel-Like Factor 152

External Ids:    HGNC: 145361   Entrez Gene: 289992   Ensembl: ENSG000001638847   OMIM: 6064655   UniProtKB: Q9UIH93   

Export aliases for KLF15 gene to outside databases

Previous GC identifers: GC03M122845 GC03M126092 GC03M127343 GC03M127382 GC03M127544 GC03M123442


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KLF15 Gene:
KLF15 (Kruppel-like factor 15) is a protein-coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF15_HUMAN, Q9UIH9
Function: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2
promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF
expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac
hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte
differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits
NF-kappa-B activation through repression of EP300-dependent RELA acetylation

Gene Wiki entry for KLF15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF15 gene promoter:
         E2F-3a   PPAR-gamma1   Sp1   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF15 promoter sequence
   Search Chromatin IP Primers for KLF15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

KLF15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF15 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M126061:  view genomic region     (about GC identifiers)

Start:
126,061,478 bp from pter      End:
126,076,285 bp from pter
Size:
14,808 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLF15_HUMAN, Q9UIH9 (See protein sequence)
Recommended Name: Krueppel-like factor 15  
Size: 416 amino acids; 43992 Da
Subunit: Interacts with MYOCD and EP300
1 PDB 3D structure from and Proteopedia for KLF15:
2ENT (3D)    

Explore the universe of human proteins at neXtProt for KLF15: NX_Q9UIH9

Explore proteomics data for KLF15 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLF15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054798.1  
    ENSEMBL proteins: 
     ENSP00000296233  

    KLF15 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9UIH9

    ProtoNet protein and cluster: Q9UIH9

    UniProtKB/Swiss-Prot: KLF15_HUMAN, Q9UIH9
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with KLF15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF15_HUMAN, Q9UIH9
    Function: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2
    promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF
    expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac
    hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte
    differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits
    NF-kappa-B activation through repression of EP300-dependent RELA acetylation
    Induction: In podocytes, up-regulated by retinoic acid

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IC19767294
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding IPI--
    GO:0044212transcription regulatory region DNA binding ISS--
         
    Find genes that share ontologies with KLF15           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLF15:
     Decreased viability of wild-ty 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klf15):
     adipose tissue  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  muscle  renal/urinary system 

    Find genes that share phenotypes with KLF15           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLF15
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLF15
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KLF15 (see all 49):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-376b hsa-miR-4305 hsa-let-7a-2* hsa-miR-632 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidKLF15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLF15

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    GenScript: all cDNA clones in your preferred vector: KLF15 (NM_014079)
    Sino Biological Human cDNA Clone for KLF15
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF15

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF15_HUMAN, Q9UIH9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17438289
    GO:0005730nucleolus ----

    Find genes that share ontologies with KLF15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLF15 About    
    See pathways by source

    SuperPathContained pathways About
    1Adipogenesis
    Adipogenesis


    1 BioSystems Pathway for KLF15
        Adipogenesis



        Pathway & Disease-focused RT2 Profiler PCR Array including KLF15: 
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KLF15

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for KLF15 (Q9UIH93 ENSP000002962334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT2BQ928313, ENSP000002637544I2D: score=1 STRING: ENSP00000263754
    SNX13ENSP000003987894STRING: ENSP00000398789
    TCF21ENSP000002373164STRING: ENSP00000237316
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010001glial cell differentiation IEA--
    GO:0015758glucose transport IEA--
    GO:0045893positive regulation of transcription, DNA-templated ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IMP19767294
    GO:0072112glomerular visceral epithelial cell differentiation ISS--

    Find genes that share ontologies with KLF15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF15

    1 Novoseek inferred chemical compound relationship for KLF15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 33.3 2 10982849 (1)



    Find genes that share compounds with KLF15           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLF15 gene: 
    NM_014079.3  

    Unigene Cluster for KLF15:

    Kruppel-like factor 15
    Hs.272215  [show with all ESTs]
    Unigene Representative Sequence: BC036733
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296233(uc011bkk.1) ENST00000509675
    miRNA
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    Block miRNA regulation of human, mouse, rat KLF15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF15 (see all 49):
    hsa-miR-548j hsa-miR-579 hsa-miR-607 hsa-miR-376b hsa-miR-4305 hsa-let-7a-2* hsa-miR-632 hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidKLF15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLF15
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF15
      QuantiTect SYBR Green Assays in human, mouse, rat KLF15
      QuantiFast Probe-based Assays in human, mouse, rat KLF15

    Additional mRNA sequence: 

    AB029254.1 BC036733.1 BX649049.1 

    1 DOTS entry:

    DT.91750479 

    Selected AceView cDNA sequences (see all 34):

    AI859036 BX280931 BI094007 AI934736 BE463683 AI360374 AI369833 BE326850 
    AI563981 BU738907 NM_014079 BC036733 BG820336 BE783185 BE552120 BM713855 
    AB029254 BE892379 BM787063 AI569813 BF939596 BX090722 AW014734 BF434881 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KLF15    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
    SP1:              -     -                           
    SP2:                    -                           
    SP3:                                                


    ECgene alternative splicing isoforms for KLF15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTGAGTT
    KLF15 Expression
    About this image


    KLF15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Kidney (Urinary System)
    KLF15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272215

    UniProtKB/Swiss-Prot: KLF15_HUMAN, Q9UIH9
    Tissue specificity: Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes.
    Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm,
    and in glomerular disease. Not expressed in bone marrow or lymphoid tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including KLF15: 
              Adipogenesis in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KLF15 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf151 , 5 Kruppel-like factor 151, 5 82.81(n)1
    84.34(a)1
      6 (40.16 cM)5
    662771  NM_023184.31  NP_075673.11 
     904625765 
    chicken
    (Gallus gallus)
    Aves KLF151 Kruppel-like factor 15 68(n)
    69.58(a)
      427588  XM_425161.3  XP_425161.3 
    lizard
    (Anolis carolinensis)
    Reptilia KLF156
    Kruppel-like factor 15
    50(a)
    1 ↔ 1
    GL343228.1(436499-445737)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia klf151 Kruppel-like factor 15 62.93(n)
    64.63(a)
      100495857  XM_002938233.2  XP_002938279.1 
    zebrafish
    (Danio rerio)
    Actinopterygii klf151 Kruppel-like factor 15 59.02(n)
    57.32(a)
      335901  NM_212746.3  NP_997911.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta EP22373 transcriptional activator 66(a)
    (best of 2)
      21C6   --


    ENSEMBL Gene Tree for KLF15 (if available)
    TreeFam Gene Tree for KLF15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF15 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF22  KLF72  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    1 SIMAP similar gene for KLF15 using alignment to 1 protein entry:     KLF15_HUMAN:
    KLF7

    Find genes that share paralogs with KLF15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF15 (see all 342)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391267301,2
    --126061079(+) CCAAGA/GCACAG 1 -- int10--------
    rs604352101,2
    F--126061119(+) GGTGGA/GCTGGA 1 -- int11Minor allele frequency- G:0.10WA 118
    rs1866328441,2
    --126061155(+) TCTCCA/GATAGC 1 -- int10--------
    rs1441370651,2
    --126061177(+) GCCTCA/GCAGGA 1 -- int10--------
    rs1460364531,2
    --126061245(+) GTTTAC/TGGAGC 1 -- int10--------
    rs1925628851,2
    --126061332(+) TGGACC/GGGGGC 1 -- int10--------
    rs1854400991,2
    --126061333(+) GGACCA/GGGGCT 1 -- int10--------
    rs1486551851,2
    --126061406(+) GTGGAG/TACATA 1 -- int10--------
    rs1421714161,2
    --126061684(+) GAAATA/GAACCT 1 -- ut310--------
    rs1398830451,2
    C--126061761(+) TGGGA-/GGCTCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KLF15 (126061478 - 126076285 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KLF15:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv29660CNV Loss19812545
    dgv5245n71CNV Loss21882294
    nsv877432CNV Loss21882294
    nsv877436CNV Loss21882294
    nsv877433CNV Loss21882294
    nsv877434CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF15
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606465    OMIM disorders: --

    UniProtKB/Swiss-Prot: KLF15_HUMAN, Q9UIH9
  • Note=KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization
    (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and
    development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365)


  • Find genes that share disorders with KLF15           About GenesLikeMe

    Genetic Association Database (GAD): KLF15
    Human Genome Epidemiology (HuGE) Navigator: KLF15 (2 documents)

    Export disorders for KLF15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF15 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with KLF15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor. (PubMed id 10982849)1, 2, 3, 9 Uchida S.... Marumo F. (Mol. Cell. Biol. 2000)
    2. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. (PubMed id 17438289)1, 2, 9 Fisch S....Jain M.K. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    3. Kruppel-like factor 15 is critical for vascular inflammation. (PubMed id 23999430)1, 2 Lu Y.... Jain M.K. (J. Clin. Invest. 2013)
    4. Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation. (PubMed id 22493483)1, 2 Mallipattu S.K....He J.C. (J. Biol. Chem. 2012)
    5. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. (PubMed id 20375365)1, 2 Haldar S.M....Jain M.K. (Sci Transl Med 2010)
    6. The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. (PubMed id 18586263)1, 2 Wang B....Jain M.K. (J. Mol. Cell. Cardiol. 2008)
    7. Analysis of KLF transcription factor family gene variants in type 2 diabetes. (PubMed id 17688680)1, 4 GutiAcrrez-Aguilar R....Neve B. (BMC Med. Genet. 2007)
    8. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (Diabetologia 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. KLF15 Is a transcriptional regulator of the human 17beta-hydroxysteroid dehydrogenase type 5 gene. A potential link between regulation of testosterone production and fat stores in women. (PubMed id 19366843)1, 9 Du X....Qin K. (J. Clin. Endocrinol. Metab. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28999 HGNC: 14536 AceView: KLF15 Ensembl:ENSG00000163884 euGenes: HUgn28999
    ECgene: KLF15 H-InvDB: KLF15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLF15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLF15 gene:
    Search GeneIP for patents involving KLF15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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