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KLF14 Gene

protein-coding   GIFtS: 49
GCID: GC07M130417

Kruppel-Like Factor 14

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kruppel-Like Factor 141 2     BTE-Binding Protein 52 3
BTEB52 3 5     Krueppel-Like Factor 142
Basic Transcription Element-Binding Protein 52 3     LKF145
Transcription Factor BTEB52 3     

External Ids:    HGNC: 230251   Entrez Gene: 1362592   Ensembl: ENSG000001745957   OMIM: 6093935   UniProtKB: Q8TD943   

Export aliases for KLF14 gene to outside databases

Previous GC identifers: GC07M129819 GC07M129833 GC07M129874 GC07M130068 GC07M124732


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLF14 Gene:
This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein
functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to
repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in
embryonic and extra-embryonic tissues. (provided by RefSeq, Jul 2013)

GeneCards Summary for KLF14 Gene:
KLF14 (Kruppel-like factor 14) is a protein-coding gene. An important paralog of this gene is KLF1.

Gene Wiki entry for KLF14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF14 gene promoter:
         HOXA9   HOXA9B   GATA-3   MyoD   C/EBPalpha   GATA-1   GATA-2   Egr-2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF14 promoter sequence
   Search Chromatin IP Primers for KLF14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32.3   Ensembl cytogenetic band:  7q32.3   HGNC cytogenetic band: 7q32.3

KLF14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF14 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M130417:  view genomic region     (about GC identifiers)

Start:
130,417,396 bp from pter      End:
130,418,888 bp from pter
Size:
1,493 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 129,753,871-129,755,364     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLF14_HUMAN, Q8TD94 (See protein sequence)
Recommended Name: Krueppel-like factor 14  
Size: 323 amino acids; 33124 Da
Secondary accessions: Q19A42 Q19A43

Explore the universe of human proteins at neXtProt for KLF14: NX_Q8TD94

Explore proteomics data for KLF14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLF14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_619638.2  
    ENSEMBL proteins: 
     ENSP00000310878  

    KLF14 Human Recombinant Protein Products:

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    antibodies-online antibodies for KLF14 (10 products) 

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    antibodies-online kits for KLF14 (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q8TD94

    ProtoNet protein and cluster: Q8TD94

    UniProtKB/Swiss-Prot: KLF14_HUMAN, Q8TD94
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with KLF14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with KLF14           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KLF14

    miRNA
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    miRTarBase miRNAs that target KLF14:
    hsa-mir-16-5p (MIRT051059), hsa-mir-378a-3p (MIRT043907), hsa-mir-30d-5p (MIRT047783)

    Block miRNA regulation of human, mouse, rat KLF14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF14 (see all 12):
    hsa-miR-3690 hsa-miR-550a hsa-miR-622 hsa-miR-4306 hsa-miR-3672 hsa-miR-519e* hsa-miR-515-5p hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmidKLF14 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF14_HUMAN, Q8TD94: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with KLF14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLF14
    Interactions:

        Search GeneGlobe Interaction Network for KLF14

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for KLF14 (ENSP000003108784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with KLF14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF14



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLF14 gene: 
    NM_138693.3  

    Unigene Cluster for KLF14:

    Kruppel-like factor 14
    Hs.125240  [show with all ESTs]
    Unigene Representative Sequence: NM_138693
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000310992(uc003vqk.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat KLF14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF14 (see all 12):
    hsa-miR-3690 hsa-miR-550a hsa-miR-622 hsa-miR-4306 hsa-miR-3672 hsa-miR-519e* hsa-miR-515-5p hsa-miR-185
    SwitchGear 3'UTR luciferase reporter plasmidKLF14 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat KLF14
      QuantiFast Probe-based Assays in human, mouse, rat KLF14

    Additional mRNA sequence: AF490374.1 

    1 DOTS entry:

    DT.104452 

    6 AceView cDNA sequences:

    AF490374 NM_138693 AA455939 AA340045 AA868945 BX100370 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGACTCTGG
    KLF14 Expression
    About this image


    KLF14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
    KLF14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.125240
        Custom PCR Arrays for KLF14
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLF14 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf141 , 5 Kruppel-like factor 141, 5 74.51(n)1
    66.25(a)1
      6 (12.54 cM)5
    6196651  NM_001135093.11  NP_001128565.11 
     309560235 
    zebrafish
    (Danio rerio)
    Actinopterygii KLF166
    Kruppel-like factor 16
    41(a)
    1 → many
    2(6943373-6951672) ENSDARG00000069342


    ENSEMBL Gene Tree for KLF14 (if available)
    TreeFam Gene Tree for KLF14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF14 gene
    KLF12  SP82  KLF172  KLF52  SP62  KLF152  KLF22  KLF72  
    KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    10 SIMAP similar genes for KLF14 using alignment to 2 protein entries:     KLF14_HUMAN (see all proteins):
    KLF7    ZNF697    ZNF323    ZNF702P    KLF11    TIEG2
    KLF16    KLF6    SP8    KLF13

    Find genes that share paralogs with KLF14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF14 (see all 89)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734729341,2
    C,F--129753432(+) TATTTC/TCCTGA 1 -- ds50012Minor allele frequency- T:0.05WA 120
    rs1413212421,2
    --129753458(+) ATGAGA/CGGTCT 1 -- ds50010--------
    rs1502196721,2
    --129753479(+) CCCGCC/TCAAAC 1 -- ds50010--------
    rs1836046511,2
    --129753517(+) GTGAAA/GGGGGA 1 -- ds50010--------
    rs624715721,2
    C,F--129753600(+) GAGAGT/CGAGCC 1 -- ds50016Minor allele frequency- C:0.36NA WA EA 364
    rs347431971,2
    C,F--129753662(+) GCAAGC/TGCAGG 1 -- ds50013Minor allele frequency- T:0.02NA WA 240
    rs1872584741,2
    --129753714(+) CCAGAC/TATCAA 1 -- ds50010--------
    rs1488807221,2
    --129753756(+) GCTTAC/TGTGGC 1 -- ds50010--------
    rs1921884261,2
    --129754038(+) GAATTC/TCAGTT 1 -- ut310--------
    rs39095531,2
    C,F,A,H--129754290(-) CCATCC/TTTCTT 1 -- ut3116Minor allele frequency- T:0.06NS EA NA WA 2062

    HapMap Linkage Disequilibrium report for KLF14 (130417396 - 130418888 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KLF14: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF14
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609393    OMIM disorders: --


    Find genes that share disorders with KLF14           About GenesLikeMe

    Genetic Association Database (GAD): KLF14
    Human Genome Epidemiology (HuGE) Navigator: KLF14 (6 documents)

    Export disorders for KLF14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF14 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with KLF14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827)1, 4 Voight B.F.... . (Nat. Genet. 2010)
    2. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    3. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PubMed id 19936222)1, 4 Chasman D.I....Ridker P.M. (PLoS Genet. 2009)
    4. New common variants affecting susceptibility to basal cell carcinoma. (PubMed id 19578363)1, 4 Stacey S.N....Stefansson K. (Nat. Genet. 2009)
    5. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. (PubMed id 17480121)1, 3 Parker-Katiraee L....Scherer S.W. (PLoS Genet. 2007)
    6. Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians. (PubMed id 23630301)1 Hanson R.L....Baier L.J. (Diabetes 2013)
    7. Involvement of KLF14 and egr-1 in the TGF-beta1 action on Leydig cell proliferation. (PubMed id 23317878)1 Gonzalez C.R....Gonzalez Calvar S.I. (Cytokine 2013)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. (PubMed id 21572415)1 Small K.S....McCarthy M.I. (Nat. Genet. 2011)
    10. A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth. (PubMed id 21171965)1 Fernandez-Zapico M.E....Urrutia R. (Biochem. J. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 136259 HGNC: 23025 AceView: KLF14 Ensembl:ENSG00000174595 euGenes: HUgn136259
    ECgene: KLF14 H-InvDB: KLF14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLF14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLF14 gene:
    Search GeneIP for patents involving KLF14

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat KLF14 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing KLF14
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