KLF14 Gene
protein-coding GIFtS : 47 GCID: GC07 M130417
Kruppel-like factor 14
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Aliasesfor KLF14 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Kruppel-Like Factor 14 1 2 BTEB51 2 3 Basic Transcription Element-Binding Protein 52 3 Transcription Factor BTEB52 3 BTE-Binding Protein 52 3 Krueppel-Like Factor 142
Export aliases for KLF14 gene to outside databases Previous GC identifers: GC07M129819 GC07M129833 GC07M129874 GC07M130068 GC07M124732
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Summariesfor KLF14 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for KLF14 : This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2. (provided by RefSeq, Nov 2009) Gene Wiki entry for KLF14
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Genomic Viewsfor KLF14 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the KLF14 gene promoter:HOXA9 HOXA9B GATA-3 MyoD C/EBPalpha GATA-1 GATA-2 Egr-2 Meis-1a Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for KLF14 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q32.3 Ensembl cytogenetic band: 7q32.3 HGNC cytogenetic band: 7q32.3 KLF14 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M130417: view genomic region
(about GC identifiers )
Start: 130,417,396 bp from pter End:
130,418,888 bp from pter
Size: 1,493 bases Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 129,753,871-129,755,364
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Proteinsfor KLF14 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: KLF14_HUMAN, Q8TD94 See
protein sequence )Recommended Name: Size : 323 amino acids; 33124 DaSubcellular location : Nucleus (By similarity)Secondary accessions : Q19A42 Q19A43Explore the universe of human proteins at neXtProt for KLF14: NX_Q8TD94 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8TD94 KLF14 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_619638.1 ENSEMBL proteins: ENSP00000310878 Human Recombinant Protein Products for KLF14: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
About GeneDecksing KLF14 Antibody Products: Assay Products for KLF14:
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Protein
Domains /for KLF14 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8TD94 ProtoNet protein and cluster: Q8TD94
UniProtKB/Swiss-Prot: KLF14_HUMAN, Q8TD94 Similarity : Belongs to the Sp1 C2H2-type zinc-finger protein familySimilarity : Contains 3 C2H2-type zinc fingers
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Functionfor KLF14 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLF14 (NM_138693 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLF14 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat KLF14
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF14
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Pathways & Interactionsfor KLF14 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLF14 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)1 Interacting protein for KLF14 (ENSP00000310878 4 via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA --
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Drugs & Compoundsfor KLF14 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for KLF14 KLF14
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Transcriptsfor KLF14 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
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Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for KLF14 gene: NM_138693.2 Unigene Cluster for KLF14:
Kruppel-like factor 14 Hs.125240 [show with all ESTs ] Unigene Representative Sequence: NM_138693 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000310992 (uc003vqk.2 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: KLF14 (NM_138693 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KLF14 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat KLF14
Additional cDNA sequence: AF490374.1
1 DOTS entry : DT.104452
6 AceView cDNA sequences :
NM_138693 AF490374 AA455939 AA340045 BX100370 AA868945 GeneLoc Exon Structure
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Expression for KLF14 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section KLF14 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGGACTCTGGAbout this image KLF14 expression in embryonic tissues and stem cells About this table
See KLF14 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for KLF14 SOURCE GeneReport for Unigene cluster: Hs.125240 SABiosciences Custom PCR Arrays for KLF14 Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF14
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Orthologsfor KLF14 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for KLF14 gene from 4/16 species (see all 16 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
lizard Reptilia --
--
4(a)
possible ortholog
3(88021848-88042132)
zebrafish Actinopterygii zgc:1531156
zgc:153115
31(a)
1 → many
2(6943374-6951681)
honey bee Insecta --
--
5(a)
possible ortholog
GroupUn.224(42583-44730)
worm Secernentea sptf-16
Specificity Protein) Transcription Factor family m... 10(a)
possible ortholog
I(10366612-10371685)
ENSEMBL Gene Tree for KLF14 (if available)TreeFam Gene Tree for KLF14 (if available)
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Paralogsfor KLF14 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for KLF14 gene KLF1 2 KLF11 2 KLF6 2 KLF10 2 KLF4 2 KLF5 2 KLF16 2 KLF2 2 KLF15 2 KLF9 2 KLF12 2 KLF3 2 KLF7 2 KLF13 2 KLF8 2 11 SIMAP similar genes for KLF14 using alignment to 2 protein entries: KLF14_HUMAN (see all proteins ):KLF7 ZNF697 ZNF323 ZNF702P KLF11 TIEG2 KLF16 KLF6 SP8 KLF13 KLF12 About GeneDecksing
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Genomic Variantsfor KLF14 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 7 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for KLF14 (130417396 - 130418888 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for KLF14: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor KLF14 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 609393
OMIM disorders : --3 : About MalaCards basal cell carcinoma cholesterol carcinoma Human Genome Epidemiology (HuGE) Navigator: KLF14 (6 documents) Export disorders for KLF14 gene to outside databases
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Publicationsfor KLF14 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for KLF14 gene, integrated from 9 sources (see all 11 ):(articles sorted by number of sources associating them with KLF14) Utopia : connect your pdf to the dynamic
Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. (PubMed id 17480121) 1 , 3(2007) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 (2011) Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. (PubMed id 21572415) 1 (2011) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PubMed id 20581827) 1 (2010) Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565) 1 (2010) Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide pol ymorphisms. (PubMed id 20889853) 1 (2010) Forty-three loci associated with plasma lipoprotein s ize, concentration, and cholesterol content in genome-wide analysis. (PubMed id 19936222) 1 (2009) New common variants affecting susceptibility to basal cell carcinoma. (PubMed id 19578363) 1 (2009) Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. (PubMed id 19088080) 1 (2009) Mammalian SP/KLF transcription factors: bring in the family. (PubMed id 15820306) 1 (2005)
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External Searches for KLF14 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing KLF14 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing KLF14 gene
(According to HUGE )
About This Section --
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Specialized Databases showing KLF14 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for KLF14 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for KLF14 gene: KLF14 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor KLF14 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for KLF14 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for KLF14 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for KLF14 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for KLF14 OriGene Custom Protein Services for KLF14 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KLF14 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF14
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat KLF14
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization
