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Aliases for KLF14 Gene

Aliases for KLF14 Gene

  • Kruppel-Like Factor 14 2 3 5
  • Basic Transcription Element-Binding Protein 5 3 4
  • Transcription Factor BTEB5 3 4
  • BTE-Binding Protein 5 3 4
  • BTEB5 3 4

External Ids for KLF14 Gene

Previous GeneCards Identifiers for KLF14 Gene

  • GC07M129819
  • GC07M129833
  • GC07M129874
  • GC07M130068
  • GC07M130417
  • GC07M124732

Summaries for KLF14 Gene

Entrez Gene Summary for KLF14 Gene

  • This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]

GeneCards Summary for KLF14 Gene

KLF14 (Kruppel-Like Factor 14) is a Protein Coding gene. An important paralog of this gene is SP4.

Gene Wiki entry for KLF14 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF14 Gene

Genomics for KLF14 Gene

Regulatory Elements for KLF14 Gene


Promoters for KLF14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLF14 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLF14 Gene

Chromosome:
7
Start:
130,731,235 bp from pter
End:
130,734,061 bp from pter
Size:
2,827 bases
Orientation:
Minus strand

Genomic View for KLF14 Gene

Genes around KLF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF14 Gene

Proteins for KLF14 Gene

  • Protein details for KLF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD94-KLF14_HUMAN
    Recommended name:
    Krueppel-like factor 14
    Protein Accession:
    Q8TD94
    Secondary Accessions:
    • Q19A42
    • Q19A43

    Protein attributes for KLF14 Gene

    Size:
    323 amino acids
    Molecular mass:
    33124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF14 Gene

Proteomics data for KLF14 Gene at MOPED

Post-translational modifications for KLF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KLF14 Gene

Domains & Families for KLF14 Gene

Protein Domains for KLF14 Gene

Suggested Antigen Peptide Sequences for KLF14 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TD94

UniProtKB/Swiss-Prot:

KLF14_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF14: view

Function for KLF14 Gene

Gene Ontology (GO) - Molecular Function for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with KLF14: view

Phenotypes for KLF14 Gene

MGI mutant phenotypes for KLF14:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with KLF14: view

Animal Models for KLF14 Gene

MGI Knock Outs for KLF14:

Animal Model Products

miRNA for KLF14 Gene

miRTarBase miRNAs that target KLF14
Targeted motifs for KLF14 Gene
HOMER Transcription Factor Regulatory Elements motif KLF14
  • Consensus sequence: RGKGGGCGKGGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF14 Gene

Localization for KLF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF14 Gene COMPARTMENTS Subcellular localization image for KLF14 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for KLF14 Gene

Pathways & Interactions for KLF14 Gene

SuperPathways for KLF14 Gene

No Data Available

Interacting Proteins for KLF14 Gene

Gene Ontology (GO) - Biological Process for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,IMP 24759103
genes like me logo Genes that share ontologies with KLF14: view

No data available for Pathways by source and SIGNOR curated interactions for KLF14 Gene

Drugs & Compounds for KLF14 Gene

No Compound Related Data Available

Transcripts for KLF14 Gene

mRNA/cDNA for KLF14 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLF14 Gene

Kruppel-like factor 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF14 Gene

No ASD Table

Relevant External Links for KLF14 Gene

GeneLoc Exon Structure for
KLF14
ECgene alternative splicing isoforms for
KLF14

Expression for KLF14 Gene

mRNA expression in normal human tissues for KLF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF14 Gene

This gene is overexpressed in Whole Blood (x15.9), Testis (x5.6), and Adrenal Gland (x5.5).

SOURCE GeneReport for Unigene cluster for KLF14 Gene Hs.125240

genes like me logo Genes that share expression patterns with KLF14: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KLF14 Gene

Orthologs for KLF14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLF14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLF14 35
  • 84.31 (n)
  • 77.5 (a)
dog
(Canis familiaris)
Mammalia KLF14 35
  • 87.72 (n)
  • 84.13 (a)
mouse
(Mus musculus)
Mammalia Klf14 35
  • 74.51 (n)
  • 66.25 (a)
Klf14 16
chimpanzee
(Pan troglodytes)
Mammalia KLF14 35
  • 99.48 (n)
  • 99.07 (a)
rat
(Rattus norvegicus)
Mammalia Klf14 35
  • 75.73 (n)
  • 66.56 (a)
Species with no ortholog for KLF14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLF14 Gene

ENSEMBL:
Gene Tree for KLF14 (if available)
TreeFam:
Gene Tree for KLF14 (if available)

Paralogs for KLF14 Gene

Paralogs for KLF14 Gene

(10) SIMAP similar genes for KLF14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KLF14: view

Variants for KLF14 Gene

Sequence variations from dbSNP and Humsavar for KLF14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_052718 -
rs150219672 -- 130,732,176(+) CCCGC(C/T)CAAAC downstream-variant-500B
rs78613776 -- 130,732,200(+) AGTTT(C/T)CTCTC downstream-variant-500B
rs141321242 -- 130,732,155(+) ATGAG(A/C)GGTCT downstream-variant-500B
rs112041862 -- 130,732,178(+) CGCCC(-/A)AACTT downstream-variant-500B

Variation tolerance for KLF14 Gene

Gene Damage Index Score: 8.75; 86.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF14 Gene

HapMap Linkage Disequilibrium report
KLF14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KLF14 Gene

Disorders for KLF14 Gene

Relevant External Links for KLF14

Genetic Association Database (GAD)
KLF14
Human Genome Epidemiology (HuGE) Navigator
KLF14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF14

No disorders were found for KLF14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF14 Gene

Publications for KLF14 Gene

  1. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 48 67
  2. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. (PMID: 17480121) Parker-Katiraee L. … Scherer S.W. (PLoS Genet. 2007) 2 3
  3. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. (PMID: 26368306) Guo Y. … Chen Y.E. (J. Clin. Invest. 2015) 3
  4. Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma. (PMID: 24403052) Stacey S.N. … Stefansson K. (Hum. Mol. Genet. 2014) 3
  5. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. (PMID: 24759103) de Assuncao T.M. … Shah V.H. (J. Biol. Chem. 2014) 3

Products for KLF14 Gene

Sources for KLF14 Gene

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