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Aliases for KLF14 Gene

Aliases for KLF14 Gene

  • Kruppel Like Factor 14 2 3 5
  • Basic Transcription Element-Binding Protein 5 3 4
  • Transcription Factor BTEB5 3 4
  • BTE-Binding Protein 5 3 4
  • BTEB5 3 4
  • Krueppel-Like Factor 14 3

External Ids for KLF14 Gene

Previous GeneCards Identifiers for KLF14 Gene

  • GC07M129819
  • GC07M129833
  • GC07M129874
  • GC07M130068
  • GC07M130417
  • GC07M124732

Summaries for KLF14 Gene

Entrez Gene Summary for KLF14 Gene

  • This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]

GeneCards Summary for KLF14 Gene

KLF14 (Kruppel Like Factor 14) is a Protein Coding gene. An important paralog of this gene is KLF16.

Gene Wiki entry for KLF14 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF14 Gene

Genomics for KLF14 Gene

Regulatory Elements for KLF14 Gene

Enhancers for KLF14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F130241 1.2 Ensembl ENCODE 10.3 +491.3 491345 1.9 HDAC1 PKNOX1 ATF1 ARNT TBL1XR1 CREB3L1 ZNF2 RAD21 CHAMP1 GATA2 MEST CPA4 CPA2 CPA1 KLHDC10 KLF14 ENSG00000270992 TMEM209
GH07F130069 1.2 ENCODE 9.8 +663.2 663159 3.6 PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 ZNF548 CDC26P1 KLF14 LOC100128325 KLHDC10 PIR32855
GH07F130113 0.9 ENCODE 9.6 +620.2 620152 2.1 ELF3 ARID4B RARA YY1 FOS CREM MIXL1 THAP11 CEBPB TBX21 KLHDC10 KLF14 PIR32855
GH07F130852 0.7 ENCODE 9.7 -119.6 -119632 3.4 PKNOX1 JUN SIN3A RAD21 RFX5 FOSL2 FOS TCF7L2 CHD2 NR2F1 MIR29A KLF14 MIR29B1 ENSG00000233559 GC07P130851
GH07F130209 0.7 ENCODE 9.7 +523.8 523773 1.0 HDAC1 SMARCA5 L3MBTL2 GFI1B FEZF1 ZNF366 SMARCA4 ZNF512 ZBTB33 FOXP2 LOC100128325 MEST KLF14 TMEM209 ENSG00000270992
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLF14 on UCSC Golden Path with GeneCards custom track

Promoters for KLF14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for KLF14 Gene

130,731,235 bp from pter
130,734,061 bp from pter
2,827 bases
Minus strand

Genomic View for KLF14 Gene

Genes around KLF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF14 Gene

Proteins for KLF14 Gene

  • Protein details for KLF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Krueppel-like factor 14
    Protein Accession:
    Secondary Accessions:
    • Q19A42
    • Q19A43

    Protein attributes for KLF14 Gene

    323 amino acids
    Molecular mass:
    33124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF14 Gene

Post-translational modifications for KLF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF14 Gene

Domains & Families for KLF14 Gene

Gene Families for KLF14 Gene

Protein Domains for KLF14 Gene

Suggested Antigen Peptide Sequences for KLF14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF14: view

Function for KLF14 Gene

Gene Ontology (GO) - Molecular Function for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF14: view

Phenotypes for KLF14 Gene

MGI mutant phenotypes for KLF14:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with KLF14: view

Animal Models for KLF14 Gene

MGI Knock Outs for KLF14:

Animal Model Products

miRNA for KLF14 Gene

miRTarBase miRNAs that target KLF14
Targeted motifs for KLF14 Gene
HOMER Transcription Factor Regulatory Elements motif KLF14
  • Consensus sequence: RGKGGGCGKGGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF14 Gene

Localization for KLF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF14 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF14: view

Pathways & Interactions for KLF14 Gene

SuperPathways for KLF14 Gene

No Data Available

Interacting Proteins for KLF14 Gene

Selected Interacting proteins: Q8TD94-KLF14_HUMAN for KLF14 Gene via IID

Gene Ontology (GO) - Biological Process for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,IMP 24759103
GO:1902070 positive regulation of sphingolipid mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with KLF14: view

No data available for Pathways by source and SIGNOR curated interactions for KLF14 Gene

Transcripts for KLF14 Gene

mRNA/cDNA for KLF14 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLF14 Gene

Kruppel-like factor 14:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF14 Gene

No ASD Table

Relevant External Links for KLF14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF14 Gene

This gene is overexpressed in Whole Blood (x15.9), Testis (x5.6), and Adrenal Gland (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of KLF14 Gene:


SOURCE GeneReport for Unigene cluster for KLF14 Gene:

genes like me logo Genes that share expression patterns with KLF14: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KLF14 Gene

Orthologs for KLF14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLF14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLF14 34
  • 99.48 (n)
(Canis familiaris)
Mammalia KLF14 34
  • 87.72 (n)
(Bos Taurus)
Mammalia KLF14 34
  • 84.31 (n)
(Rattus norvegicus)
Mammalia Klf14 34
  • 75.73 (n)
(Mus musculus)
Mammalia Klf14 34 16
  • 74.51 (n)
Species where no ortholog for KLF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLF14 Gene

Gene Tree for KLF14 (if available)
Gene Tree for KLF14 (if available)

Paralogs for KLF14 Gene

Paralogs for KLF14 Gene

(10) SIMAP similar genes for KLF14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KLF14: view

Variants for KLF14 Gene

Sequence variations from dbSNP and Humsavar for KLF14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10228715 -- 130,733,419(+) TAATA(C/G)GCTTT upstream-variant-2KB, reference, synonymous-codon
rs111359117 -- 130,733,893(+) TCCGG(A/C)TGCGC upstream-variant-2KB, reference, synonymous-codon
rs111400400 -- 130,733,862(+) CCCCG(A/G)TGGCC upstream-variant-2KB, reference, missense
rs111731678 -- 130,733,917(+) GAGCC(A/T)GCGGC upstream-variant-2KB, reference, synonymous-codon
rs112041862 -- 130,732,178(+) CGCCC(-/A)AACTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KLF14 Gene

Variant ID Type Subtype PubMed ID
nsv1029405 CNV gain 25217958
nsv608421 CNV gain 21841781

Variation tolerance for KLF14 Gene

Gene Damage Index Score: 8.75; 86.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF14 Gene

Disorders for KLF14 Gene

Relevant External Links for KLF14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLF14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF14 Gene

Publications for KLF14 Gene

  1. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PMID: 20581827) Voight B.F. … . (Nat. Genet. 2010) 3 46 64
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 46 64
  3. New common variants affecting susceptibility to basal cell carcinoma. (PMID: 19578363) Stacey S.N. … Stefansson K. (Nat. Genet. 2009) 3 46 64
  4. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PMID: 19936222) Chasman D.I. … Ridker P.M. (PLoS Genet. 2009) 3 46 64
  5. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. (PMID: 17480121) Parker-Katiraee L. … Scherer S.W. (PLoS Genet. 2007) 2 3 64

Products for KLF14 Gene

Sources for KLF14 Gene

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