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Aliases for KLF14 Gene

Aliases for KLF14 Gene

  • Kruppel Like Factor 14 2 3 5
  • Basic Transcription Element-Binding Protein 5 3 4
  • Transcription Factor BTEB5 3 4
  • BTE-Binding Protein 5 3 4
  • BTEB5 3 4
  • Krueppel-Like Factor 14 3

External Ids for KLF14 Gene

Previous GeneCards Identifiers for KLF14 Gene

  • GC07M129819
  • GC07M129833
  • GC07M129874
  • GC07M130068
  • GC07M130417
  • GC07M124732

Summaries for KLF14 Gene

Entrez Gene Summary for KLF14 Gene

  • This intronless gene encodes a member of the Kruppel-like family of transcription factors. The encoded protein functions as a transcriptional co-repressor, and is induced by transforming growth factor-beta (TGF-beta) to repress TGF-beta receptor II gene expression. This gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. [provided by RefSeq, Jul 2013]

GeneCards Summary for KLF14 Gene

KLF14 (Kruppel Like Factor 14) is a Protein Coding gene. An important paralog of this gene is KLF16.

Gene Wiki entry for KLF14 Gene

Additional gene information for KLF14 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF14 Gene

Genomics for KLF14 Gene

Regulatory Elements for KLF14 Gene

Enhancers for KLF14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H130241 1.2 Ensembl ENCODE 10.3 +491.3 491345 1.9 PKNOX1 ATF1 ZNF2 TCF12 GATA2 ZNF143 FOS ATF7 RUNX3 YY2 MEST CPA4 CPA2 CPA1 KLHDC10 KLF14 ENSG00000270992 TMEM209
GH07H130069 1.2 ENCODE 9.8 +663.2 663159 3.6 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 CBX5 NRF1 TMEM209 KLF14 CDC26P1 LOC100128325 KLHDC10 PIR32855
GH07H130113 0.9 ENCODE 9.6 +620.2 620152 2.1 ELF3 FOXA2 ARID4B RAD21 RARA YY1 FOS CREM MIXL1 THAP11 KLHDC10 KLF14 PIR32855
GH07H130852 0.7 ENCODE 9.7 -119.6 -119632 3.4 PKNOX1 FOXA2 JUN CEBPB MNT RAD21 EP300 RFX5 CTBP1 JUND MIR29A KLF14 ENSG00000226380 GC07P130851 LINC00513
GH07H130209 0.7 ENCODE 9.7 +523.8 523773 1 SMARCA5 FOXA2 L3MBTL2 GFI1B FEZF1 PRDM6 NFIC SMARCA4 ZSCAN5C ZBTB33 LOC100128325 MEST KLF14 TMEM209 ENSG00000270992
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLF14 on UCSC Golden Path with GeneCards custom track

Promoters for KLF14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000218022 -139 801 SOX13 CTCF ZNF76 ZIC2 FOXM1 GLIS2 EGR1 PATZ1 KLF8 ZBTB20

Genomic Locations for KLF14 Gene

Genomic Locations for KLF14 Gene
2,827 bases
Minus strand

Genomic View for KLF14 Gene

Genes around KLF14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF14 Gene

Proteins for KLF14 Gene

  • Protein details for KLF14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Krueppel-like factor 14
    Protein Accession:
    Secondary Accessions:
    • Q19A42
    • Q19A43

    Protein attributes for KLF14 Gene

    323 amino acids
    Molecular mass:
    33124 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KLF14 Gene

Post-translational modifications for KLF14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF14 Gene

Domains & Families for KLF14 Gene

Gene Families for KLF14 Gene

Protein Domains for KLF14 Gene


Suggested Antigen Peptide Sequences for KLF14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF14: view

Function for KLF14 Gene

Phenotypes From GWAS Catalog for KLF14 Gene

Gene Ontology (GO) - Molecular Function for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IC --
GO:0003682 chromatin binding IEA --
GO:0043565 sequence-specific DNA binding IDA 23332764
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF14: view
genes like me logo Genes that share phenotypes with KLF14: view

Animal Models for KLF14 Gene

MGI Knock Outs for KLF14:

miRNA for KLF14 Gene

miRTarBase miRNAs that target KLF14
Targeted motifs for KLF14 Gene
HOMER Transcription Factor Regulatory Elements motif KLF14
  • Consensus sequence: RGKGGGCGKGGC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF14 Gene

Localization for KLF14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF14 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF14: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KLF14 Gene

Pathways & Interactions for KLF14 Gene

SuperPathways for KLF14 Gene

No Data Available

Interacting Proteins for KLF14 Gene

Selected Interacting proteins: Q8TD94-KLF14_HUMAN for KLF14 Gene via IID

Gene Ontology (GO) - Biological Process for KLF14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP,IEA 24759103
GO:1902070 positive regulation of sphingolipid mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with KLF14: view

No data available for Pathways by source and SIGNOR curated interactions for KLF14 Gene

Drugs & Compounds for KLF14 Gene

No Compound Related Data Available

Transcripts for KLF14 Gene

mRNA/cDNA for KLF14 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KLF14 Gene

Kruppel-like factor 14:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF14 Gene

No ASD Table

Relevant External Links for KLF14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KLF14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF14 Gene

This gene is overexpressed in Whole Blood (x15.9), Testis (x5.6), and Adrenal Gland (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of KLF14 Gene:


SOURCE GeneReport for Unigene cluster for KLF14 Gene:

genes like me logo Genes that share expression patterns with KLF14: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF14 Gene

Orthologs for KLF14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KLF14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLF14 33
  • 99.48 (n)
(Canis familiaris)
Mammalia KLF14 33
  • 87.72 (n)
(Bos Taurus)
Mammalia KLF14 33
  • 84.31 (n)
(Rattus norvegicus)
Mammalia Klf14 33
  • 75.73 (n)
(Mus musculus)
Mammalia Klf14 33 16
  • 74.51 (n)
Species where no ortholog for KLF14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KLF14 Gene

Gene Tree for KLF14 (if available)
Gene Tree for KLF14 (if available)

Paralogs for KLF14 Gene

Paralogs for KLF14 Gene

(10) SIMAP similar genes for KLF14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KLF14: view

Variants for KLF14 Gene

Sequence variations from dbSNP and Humsavar for KLF14 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000410525 -- 130,735,157(+) TTGCT(A/C)TCATT intron-variant, upstream-variant-2KB
rs1005938779 -- 130,732,182(+) CAAAC(C/T)TAAGG downstream-variant-500B
rs1006162693 -- 130,732,395(+) CAAAC(A/T)GACTC downstream-variant-500B, upstream-variant-2KB
rs1006546357 -- 130,732,725(+) AGGCA(C/T)CTGAG upstream-variant-2KB, utr-variant-3-prime
rs1006778615 -- 130,735,949(+) TGTCT(C/T)ATATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KLF14 Gene

Variant ID Type Subtype PubMed ID
nsv608421 CNV gain 21841781
nsv1029405 CNV gain 25217958

Variation tolerance for KLF14 Gene

Gene Damage Index Score: 8.75; 86.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF14 Gene

Disorders for KLF14 Gene

Relevant External Links for KLF14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KLF14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLF14 Gene

Publications for KLF14 Gene

  1. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. (PMID: 20581827) Voight BF … GIANT Consortium (Nature genetics 2010) 3 45 60
  2. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 45 60
  3. New common variants affecting susceptibility to basal cell carcinoma. (PMID: 19578363) Stacey SN … Stefansson K (Nature genetics 2009) 3 45 60
  4. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. (PMID: 19936222) Chasman DI … Ridker PM (PLoS genetics 2009) 3 45 60
  5. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. (PMID: 17480121) Parker-Katiraee L … Scherer SW (PLoS genetics 2007) 2 3 60

Products for KLF14 Gene

Sources for KLF14 Gene

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