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Aliases for KLF12 Gene

Aliases for KLF12 Gene

  • Kruppel-Like Factor 12 2 3 5
  • KLF12 Zinc Finger Transcriptional Repressor 2 3
  • Transcriptional Repressor AP-2rep 3 4
  • AP-2rep Transcription Factor 2 3
  • AP-2 Repressor 2 3
  • AP2REP 3 4
  • AP-2rep 3
  • HSPC122 3

External Ids for KLF12 Gene

Previous GeneCards Identifiers for KLF12 Gene

  • GC13M072227
  • GC13M068255
  • GC13M073196
  • GC13M072058
  • GC13M073158
  • GC13M074260
  • GC13M054957

Summaries for KLF12 Gene

Entrez Gene Summary for KLF12 Gene

  • Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLF12 Gene

KLF12 (Kruppel-Like Factor 12) is a Protein Coding gene. Diseases associated with KLF12 include wegener granulomatosis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is KLF8.

UniProtKB/Swiss-Prot for KLF12 Gene

  • Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Gene Wiki entry for KLF12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF12 Gene

Genomics for KLF12 Gene

Regulatory Elements for KLF12 Gene

Genomic Location for KLF12 Gene

Chromosome:
13
Start:
73,686,012 bp from pter
End:
74,168,169 bp from pter
Size:
482,158 bases
Orientation:
Minus strand

Genomic View for KLF12 Gene

Genes around KLF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF12 Gene

Proteins for KLF12 Gene

  • Protein details for KLF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4X4-KLF12_HUMAN
    Recommended name:
    Krueppel-like factor 12
    Protein Accession:
    Q9Y4X4
    Secondary Accessions:
    • A8K5T2
    • L0R3J4
    • Q5VZM7
    • Q9UHZ0

    Protein attributes for KLF12 Gene

    Size:
    402 amino acids
    Molecular mass:
    44240 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KLF12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF12 Gene

Proteomics data for KLF12 Gene at MOPED

Post-translational modifications for KLF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLF12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KLF12 Gene

Domains & Families for KLF12 Gene

Protein Domains for KLF12 Gene

Suggested Antigen Peptide Sequences for KLF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4X4

UniProtKB/Swiss-Prot:

KLF12_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF12: view

Function for KLF12 Gene

Molecular function for KLF12 Gene

UniProtKB/Swiss-Prot Function:
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.

Gene Ontology (GO) - Molecular Function for KLF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity TAS 10704285
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with KLF12: view
genes like me logo Genes that share phenotypes with KLF12: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KLF12

Transcription Factor Targets for KLF12 Gene

Selected GeneGlobe predicted Target genes for KLF12

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for KLF12 Gene

Localization for KLF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF12 Gene COMPARTMENTS Subcellular localization image for KLF12 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for KLF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with KLF12: view

Pathways & Interactions for KLF12 Gene

SuperPathways for KLF12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KLF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KLF12: view

No data available for Pathways by source and SIGNOR curated interactions for KLF12 Gene

Drugs & Compounds for KLF12 Gene

(1) Drugs for KLF12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF12: view

Transcripts for KLF12 Gene

Unigene Clusters for KLF12 Gene

Kruppel-like factor 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6:
SP7:

Relevant External Links for KLF12 Gene

GeneLoc Exon Structure for
KLF12
ECgene alternative splicing isoforms for
KLF12

Expression for KLF12 Gene

mRNA expression in normal human tissues for KLF12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLF12 Gene

This gene is overexpressed in CD8 Tcells (28.2), Tlymphocyte (27.0), Blymphocyte (6.6), and NK cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF12 Gene



SOURCE GeneReport for Unigene cluster for KLF12 Gene Hs.373857

genes like me logo Genes that share expression patterns with KLF12: view

Protein tissue co-expression partners for KLF12 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KLF12 Gene

Orthologs for KLF12 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF12 36
  • 100 (a)
OneToOne
KLF12 35
  • 99.67 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia KLF12 36
  • 99 (a)
OneToOne
KLF12 35
  • 94.69 (n)
  • 99 (a)
dog
(Canis familiaris)
Mammalia KLF12 35
  • 95.27 (n)
  • 99 (a)
KLF12 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf12 16
Klf12 36
  • 97 (a)
OneToOne
Klf12 35
  • 90.63 (n)
  • 97.01 (a)
oppossum
(Monodelphis domestica)
Mammalia KLF12 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf12 35
  • 90.05 (n)
  • 96.27 (a)
chicken
(Gallus gallus)
Aves KLF12 35
  • 83.42 (n)
  • 90.1 (a)
KLF12 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF12 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf12 35
  • 79.98 (n)
  • 89.66 (a)
zebrafish
(Danio rerio)
Actinopterygii klf12a 36
  • 61 (a)
OneToMany
klf12b 36
  • 80 (a)
OneToMany
klf12b 35
  • 71.27 (n)
  • 78.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12029 37
  • 72 (a)
CG9895 37
  • 80 (a)
CG42741 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53F8.1 37
  • 60 (a)
F56F11.3 37
  • 73 (a)
mua-1 37
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for KLF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLF12 Gene

ENSEMBL:
Gene Tree for KLF12 (if available)
TreeFam:
Gene Tree for KLF12 (if available)

Paralogs for KLF12 Gene

Paralogs for KLF12 Gene

(10) SIMAP similar genes for KLF12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLF12: view

Variants for KLF12 Gene

Sequence variations from dbSNP and Humsavar for KLF12 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs958593 -- 74,070,382(-) ATTCT(A/G)TCTCC intron-variant
rs1184596 -- 74,099,933(-) AGGAA(C/T)GTTTT intron-variant
rs718569 -- 73,754,562(-) ATGTG(C/T)TTTCC intron-variant
rs735816 -- 73,804,956(-) GGTTT(C/T)TAATT intron-variant
rs1057562 -- 73,846,151(-) CAACC(C/T)CTTCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KLF12 Gene

Variant ID Type Subtype PubMed ID
esv259754 OTHER Complex 20981092
nsv1086 CNV Insertion 18451855
nsv900557 CNV Loss 21882294
esv2657851 CNV Deletion 23128226
esv2747644 CNV Deletion 23290073
esv2747645 CNV Deletion 23290073
esv2747646 CNV Deletion 23290073
esv2248184 CNV Deletion 18987734
esv2747647 CNV Deletion 23290073
esv2666233 CNV Deletion 23128226
esv2747648 CNV Deletion 23290073
esv2747649 CNV Deletion 23290073
esv2747650 CNV Deletion 23290073
esv2747651 CNV Deletion 23290073
esv1702957 CNV Deletion 17803354
esv269053 CNV Insertion 20981092
esv34103 CNV Loss 18971310
esv2475756 CNV Deletion 19546169

Variation tolerance for KLF12 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF12 Gene

HapMap Linkage Disequilibrium report
KLF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF12 Gene

Disorders for KLF12 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLF12 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
wegener granulomatosis
  • wegener's granulomatosis
- elite association - COSMIC cancer census association via MalaCards
Search KLF12 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF12

Genetic Association Database (GAD)
KLF12
Human Genome Epidemiology (HuGE) Navigator
KLF12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF12
genes like me logo Genes that share disorders with KLF12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF12 Gene

Publications for KLF12 Gene

  1. Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12). (PMID: 10704285) Roth C. … Buettner R. (Genomics 2000) 2 3 4 23 67
  2. Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1. (PMID: 11373277) Schuierer M. … Buettner R. (J. Biol. Chem. 2001) 3 23
  3. Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter. (PMID: 11406275) Zhu C.H. … Domann F.E. (Biochim. Biophys. Acta 2001) 3 23
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3

Products for KLF12 Gene

Sources for KLF12 Gene

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