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KLF12 Gene

protein-coding   GIFtS: 57
GCID: GC13M074260

Kruppel-Like Factor 12

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kruppel-Like Factor 121 2     KLF12 Zinc Finger Transcriptional Repressor1 2
AP2REP2 3 5     Transcriptional Repressor AP-2rep2 3
AP-2 Repressor1 2     AP-2rep2
AP-2rep Transcription Factor1 2     Krueppel-Like Factor 122

External Ids:    HGNC: 63461   Entrez Gene: 112782   Ensembl: ENSG000001189227   OMIM: 6075315   UniProtKB: Q9Y4X43   

Export aliases for KLF12 gene to outside databases

Previous GC identifers: GC13M072227 GC13M068255 GC13M073196 GC13M072058 GC13M073158 GC13M054957


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLF12 Gene:
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator
of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member
of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a
specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a
corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for KLF12 Gene:
KLF12 (Kruppel-like factor 12) is a protein-coding gene. Diseases associated with KLF12 include wegener's granulomatosis, and coronary artery disease. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF12_HUMAN, Q9Y4X4
Function: Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in
the AP-2-alpha gene promoter

Gene Wiki entry for KLF12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF12 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF12 promoter sequence
   Search Chromatin IP Primers for KLF12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22   Ensembl cytogenetic band:  13q22.1   HGNC cytogenetic band: 13q22

KLF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF12 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M074260:  view genomic region     (about GC identifiers)

Start:
74,260,149 bp from pter      End:
74,708,394 bp from pter
Size:
448,246 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLF12_HUMAN, Q9Y4X4 (See protein sequence)
Recommended Name: Krueppel-like factor 12  
Size: 402 amino acids; 44240 Da
Secondary accessions: A8K5T2 L0R3J4 Q5VZM7 Q9UHZ0
Alternative splicing: 3 isoforms:  Q9Y4X4-1   Q9Y4X4-2   Q9Y4X4-3   

Explore the universe of human proteins at neXtProt for KLF12: NX_Q9Y4X4

Explore proteomics data for KLF12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLF12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009180.3  
    ENSEMBL proteins: 
     ENSP00000366897   ENSP00000366894  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y4X4

    ProtoNet protein and cluster: Q9Y4X4

    UniProtKB/Swiss-Prot: KLF12_HUMAN, Q9Y4X4
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    KLF12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF12_HUMAN, Q9Y4X4
    Function: Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in
    the AP-2-alpha gene promoter

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0001227RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IEA--
    GO:0003677DNA binding IDA16615998
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16615998
    GO:0003714transcription corepressor activity TAS10704285
         
    KLF12 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for KLF12:
     Decreased homologous recombina  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLF12
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLF12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KLF12

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for KLF12 (see all 68):
    ACP6,  ALPK1,  ANKDD1B,  BLOC1S3,  C3orf65,  CHMP6,  CLEC14A,  CNOT6,  COX4I2,  DBT

    miRNA
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    miRTarBase miRNAs that target KLF12:
    hsa-mir-101-3p (MIRT027368), hsa-mir-23a-3p (MIRT050396)

    Block miRNA regulation of human, mouse, rat KLF12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF12 (see all 252):
    hsa-miR-579 hsa-miR-376b hsa-miR-631 hsa-miR-106a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-938 hsa-miR-574-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLF12

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    GenScript: all cDNA clones in your preferred vector: KLF12 (NM_007249)
    Sino Biological Human cDNA Clone for KLF12
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF12

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF12_HUMAN, Q9Y4X4: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    KLF12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLF12
    Interactions:

        GeneGlobe Interaction Network for KLF12

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for KLF12 (Q9Y4X42, 3 ENSP000003668944) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206376Q96KQ72, 3MINT-67897 I2D: score=5 
    ENSG00000232045Q96KQ72, 3MINT-67897 I2D: score=5 
    ENSG00000236759Q96KQ72, 3MINT-67897 I2D: score=5 
    ENSG00000238134Q96KQ72, 3MINT-67897 I2D: score=5 
    ENSG00000227333Q96KQ72, 3, ENSP000003973234MINT-67897 I2D: score=5 STRING: ENSP00000397323
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16615998
    GO:0006351transcription, DNA-templated ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10704285
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    KLF12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF12

    1 Novoseek inferred chemical compound relationship for KLF12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 36.6 4 10704285 (2), 11373277 (1)



    KLF12 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KLF12 gene (2 alternative transcripts): 
    NM_016285.2  NM_007249.4  

    Unigene Cluster for KLF12:

    Kruppel-like factor 12
    Hs.373857  [show with all ESTs]
    Unigene Representative Sequence: NM_007249
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377669(uc001vjf.3 uc010aeq.3) ENST00000472022(uc001vjg.3)
    ENST00000377666
    miRNA
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    Block miRNA regulation of human, mouse, rat KLF12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF12 (see all 252):
    hsa-miR-579 hsa-miR-376b hsa-miR-631 hsa-miR-106a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-938 hsa-miR-574-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KLF12
    Predesigned siRNA for gene silencing in human, mouse, rat KLF12
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    OriGene clones in human, mouse for KLF12 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: KLF12 (NM_007249)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF12
    Primer
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    OriGene qPCR primer pairs and template standards for KLF12
    OriGene qSTAR qPCR primer pairs in human, mouse for KLF12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF12
      QuantiTect SYBR Green Assays in human, mouse, rat KLF12
      QuantiFast Probe-based Assays in human, mouse, rat KLF12

    Additional mRNA sequence: 

    AF113122.1 AF161471.1 AF330041.1 AJ243274.1 AK094419.1 AK096503.1 AK126412.1 AK291397.1 
    AY584194.1 BC019680.1 HF546212.1 

    9 DOTS entries:

    DT.411533  DT.414059  DT.100663571  DT.95196464  DT.95318373  DT.120768979  DT.75197796  DT.92418886 
    DT.100749748 

    Selected AceView cDNA sequences (see all 142):

    AK096503 F10254 AA814471 BM666156 AA349967 NM_007249 AW264146 AI754391 
    AA020009 AA904480 BU732372 AA349966 AA284116 AF161471 NM_016285 AW057828 
    AA720881 BU581678 AL701841 BM713563 AI431961 AW469631 AA281012 AI090652 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLF12 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                    -                           
    SP2:              -     -     -                                                                     
    SP3:        -     -     -     -                                                                     
    SP4:                                                                    -           -               
    SP5:              -     -     -     -                                                               


    ECgene alternative splicing isoforms for KLF12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGTTAAAT
    KLF12 Expression
    About this image


    KLF12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)
             Arterial Endothelial Cells Paired Dorsal Aorta
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Arterial Endothelial Cells Paired Dorsal Aorta
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
    KLF12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.373857
        Custom PCR Arrays for KLF12
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    QuantiFast Probe-based Assays in human, mouse, rat KLF12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KLF12 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf121 , 5 Kruppel-like factor 121, 5 90.63(n)1
    97.01(a)1
      14 (50.90 cM)5
    165971  NM_010636.31  NP_034766.21 
     998744865 
    chicken
    (Gallus gallus)
    Aves KLF121 Kruppel-like factor 12 83.42(n)
    90.1(a)
      418817  XM_003640556.2  XP_003640604.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLF126
    Kruppel-like factor 12
    73(a)
    1 ↔ 1
    3(87894431-88146020)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD326024.12   -- 83.66(n)    CD326024.1 
    zebrafish
    (Danio rerio)
    Actinopterygii klf12b1 Kruppel-like factor 12b 71.27(n)
    78.24(a)
      100126139  NM_001109865.1  NP_001103335.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98953 transcription factor 80(a)
    (best of 2)
      59C1   --


    ENSEMBL Gene Tree for KLF12 (if available)
    TreeFam Gene Tree for KLF12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF12 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  
    SP22  KLF102  KLF42  SP12  KLF162  KLF32  KLF92  SP72  
    SP92  
    10 SIMAP similar genes for KLF12 using alignment to 1 protein entry:     KLF12_HUMAN:
    KLF7    KLF2    KLF6    KLF8    ZNF323    ZNF702P
    KLF9    KLF3    ZNF697    KLF5

    KLF12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF12 (see all 9298)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711156301,2
    C--55289322(+) AAAAA-/AAAAA/A
    AAAAAAAAA
    GTCAA
    1 -- int11NA 2
    rs563216021,2
    C--55319647(+) AAAAA-/A/AA  
            
    CTTTA
    1 -- int11NA 2
    rs342533221,2
    C--55371263(+) CATGTCTC/-CTCCT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1813257321,2
    --74259678(+) CTATAA/TAATTA 1 -- ds50010--------
    rs1855886751,2
    --74259687(+) TATTAA/GTACTA 1 -- ds50010--------
    rs1901516101,2
    --74259745(+) TAAAAC/GACACT 1 -- ds50010--------
    rs1173381251,2
    C,F--74259787(+) ATTATT/CTGAGC 1 -- ds50011Minor allele frequency- C:0.02EA 120
    rs1818543461,2
    --74260029(+) TTATAA/TTCATT 1 -- ds50010--------
    rs1150746541,2
    C,F--74260042(+) AATATT/CAAGCT 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1486424711,2
    --74260097(+) GCTTTG/TTTAGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for KLF12 (74260149 - 74510149 bp, first 250kb of KLF12)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for KLF12 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747650CNV Deletion23290073
    esv2248184CNV Deletion18987734
    esv2747645CNV Deletion23290073
    esv2475756CNV Deletion19546169
    esv1702957CNV Deletion17803354
    esv2666233CNV Deletion23128226
    esv2657851CNV Deletion23128226
    esv2747648CNV Deletion23290073
    esv2747646CNV Deletion23290073
    esv2747644CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607531    OMIM disorders: --

    8 diseases for KLF12:    
    About MalaCards
    wegener's granulomatosis    coronary artery disease    rheumatoid arthritis    arthritis
    pancreatic cancer    schizophrenia    pancreatitis    endotheliitis


    KLF12 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KLF12
    Human Genome Epidemiology (HuGE) Navigator: KLF12 (6 documents)

    Export disorders for KLF12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF12 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with KLF12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12). (PubMed id 10704285)1, 2, 3, 9 Roth C.... Buettner R. (Genomics 2000)
    2. Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PubMed id 23134681)1, 2 Camacho-Vanegas O.... Martignetti J.A. (FASEB J. 2013)
    3. No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort. (PubMed id 19907058)1, 4 Eyre S....Barton A. (Ann. Rheum. Dis. 2010)
    4. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. (PubMed id 20101243)1, 4 Petersen G.M....Chanock S.J. (Nat. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. (PubMed id 21076409)1, 4 Sotoodehnia N....Arking D.E. (Nat. Genet. 2010)
    7. A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis. (PubMed id 20049410)1, 4 Wieczorek S....Epplen J.T. (J. Mol. Med. 2010)
    8. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    9. Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. (PubMed id 18668548)1, 4 JuliA A....Marsal S. (Arthritis Rheum. 2008)
    10. Single nucleotide polymorphisms in the gene encoding KrA1ppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (Diabetologia 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11278 HGNC: 6346 AceView: KLF12 Ensembl:ENSG00000118922 euGenes: HUgn11278
    ECgene: KLF12 H-InvDB: KLF12

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLF12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLF12 gene:
    Search GeneIP for patents involving KLF12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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