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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLF12 Gene

protein-coding   GIFtS: 55
GCID: GC13M074260

Kruppel-like factor 12
 Explore 7 diseases affiliated with
KLF12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KLF12    

Aliases
for KLF12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Kruppel-Like Factor 121 2     AP-2 Repressor2
AP2REP1 2 3 5     AP-2rep Transcription Factor2
AP-2rep1 2     KLF12 Zinc Finger Transcriptional Repressor2
Transcriptional Repressor AP-2rep2 3     Krueppel-Like Factor 122
HSPC1221     

External Ids:    HGNC: 63461   Entrez Gene: 112782   Ensembl: ENSG000001189227   OMIM: 6075315   UniProtKB: Q9Y4X43   

Export aliases for KLF12 gene to outside databases

Previous GC identifers: GC13M072227 GC13M068255 GC13M073196 GC13M072058 GC13M073158 GC13M054957


Summaries
for KLF12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for KLF12:
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of
gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the
Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific
site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1.
Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KLF12_HUMAN, Q9Y4X4
Function: Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the
AP-2-alpha gene promoter

Gene Wiki entry for KLF12


Genomic Views
for KLF12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLF12 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLF12 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLF12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22   Ensembl cytogenetic band:  13q22.1   HGNC cytogenetic band: 13q22

KLF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF12 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M074260:  view genomic region     (about GC identifiers)

Start:
 74,260,149 bp from pter      End:
 74,708,394 bp from pter
Size:
 448,246 bases      Orientation:
 minus strand

Proteins
for KLF12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KLF12_HUMAN, Q9Y4X4 (See protein sequence)
Recommended Name: Krueppel-like factor 12  
Size: 402 amino acids; 44240 Da
Subcellular location: Nucleus
Secondary accessions: A8K5T2 Q5VZM7 Q9UHZ0
Alternative splicing: 2 isoforms:  Q9Y4X4-1   Q9Y4X4-2   

Explore the universe of human proteins at neXtProt for KLF12: NX_Q9Y4X4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y4X4

    • KLF12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_009180.3  
    ENSEMBL proteins: 
     ENSP00000366897   ENSP00000366894  

    Human Recombinant Protein Products: 
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    Novus Biologicals KLF12 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for KLF12

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    KLF12 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KLF12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KLF12 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9Y4X4

    ProtoNet protein and cluster: Q9Y4X4

    UniProtKB/Swiss-Prot: KLF12_HUMAN, Q9Y4X4
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Function
    for KLF12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KLF12_HUMAN, Q9Y4X4
    Function: Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the
    AP-2-alpha gene promoter

    10/72 SABiosciences Target genes for KLF12 (see all 72):
    ACP6 ALPK1 ANKDD1B BLOC1S3 C3orf65 CHMP6 CLEC14A CNOT6 COX4I2 DBT

    miRNA
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    8/252 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF12 (see all 252):
    hsa-miR-579 hsa-miR-376b hsa-miR-631 hsa-miR-106a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-938 hsa-miR-574-3p
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF12 (see all 7)
    OriGene shRNA RFP: KLF12
    OriGene siRNA: KLF12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF12

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16615998
    GO:0003700sequence-specific DNA binding transcription factor activity IDA16615998
    GO:0003714transcription corepressor activity TAS10704285
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--


    KLF12 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for KLF12:
     Decreased homologous recombina  G0/1 arrest  Increased G1 DNA content 


    Pathways & Interactions
    for KLF12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KLF12

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for KLF12 (Q9Y4X42, 3 ENSP000003668944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EHMT2Q96KQ72, 3, ENSP000003646874MINT-67897 I2D: score=5 STRING: ENSP00000364687
    CTBP1Q133633, ENSP000002909214I2D: score=2 STRING: ENSP00000290921
    SIRT2ENSP000002493964STRING: ENSP00000249396
    --ENSP000003973234STRING: ENSP00000397323
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA16615998
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS10704285
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--


    KLF12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KLF12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KLF12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLF12
    1 Novoseek chemical compound relationship for KLF12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 36.6 4 10704285 (2), 11373277 (1)

    Search CenterWatch for drugs/clinical trials and news about KLF12 

    Transcripts
    for KLF12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KLF12 gene (2 alternative transcripts): 
    NM_016285.2  NM_007249.4  

    Unigene Cluster for KLF12:

    Kruppel-like factor 12
    Hs.373857  [show with all ESTs]
    Unigene Representative Sequence: NM_007249
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377669(uc001vjf.3 uc010aeq.3) ENST00000472022(uc001vjg.3)
    ENST00000377666

    miRNA
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    8/252 QIAGEN miScript miRNA Assays for microRNAs that regulate KLF12 (see all 252):
    hsa-miR-579 hsa-miR-376b hsa-miR-631 hsa-miR-106a hsa-miR-199a-3p hsa-miR-4305 hsa-miR-938 hsa-miR-574-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLF12 (see all 7)
    OriGene shRNA RFP: KLF12
    OriGene siRNA: KLF12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLF12
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLF12
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLF12

    Additional cDNA sequence: 

    AF113122.1 AF161471.1 AF330041.1 AJ243274.1 AK094419.1 AK096503.1 AK126412.1 AK291397.1 
    AY584194.1 BC019680.1 HF546212.1 

    9 DOTS entries:

    DT.411533  DT.414059  DT.100663571  DT.95196464  DT.95318373  DT.120768979  DT.75197796  DT.92418886 
    DT.100749748 

    24/142 AceView cDNA sequences (see all 142):

    AA281012 BE881661 AI431961 BM713563 AA814471 AL701841 BU581678 AA720881 
    AF161471 AA284116 NM_016285 AW057828 AA349966 BU732372 AA904480 AA020009 
    AI754391 NM_007249 AW264146 AA349967 BM666156 F10254 AK096503 AA232907 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KLF12 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                                    -                           
    SP2:              -     -     -                                                                     
    SP3:        -     -     -     -                                                                     
    SP4:                                                                    -           -               
    SP5:              -     -     -     -                                                               


    ECgene alternative splicing isoforms for KLF12

    Expression
    for KLF12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGGTTAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KLF12 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Lateral Plate MesodermPaired Dorsal AortaArterial endothelial cellsEndothelium
    OvaryAntral FollicleCumulus CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KLF12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLF12

    SOURCE GeneReport for Unigene cluster: Hs.373857
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    In Situ
    Assay Products:     
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    Orthologs
    for KLF12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KLF12 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KLF121 Kruppel-like factor 12 83.84(n)
    90.86(a)    		   418817  XM_003640556.1  XP_003640604.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    KLF126
    		 --
    		 89(a)
    81(a)
    		 possible ortholog
    possible ortholog
    		 3(88021848-88042132)
    3(88120827-88146020)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CD326024.12   -- 83.66(n)    CD326024.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii klf12b1 Kruppel-like factor 12b 71.76(n)
    79.71(a)    		   100126139  NM_001109865.1  NP_001103335.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 6(a)
    		 possible ortholog
    		 GroupUn.224(42583-44730)
    worm
    (Caenorhabditis elegans)    		 Secernentea F56F11.33 zinc finger protein 73(a)
    (best of 3)    		   III(2946712-2952243)   --


    ENSEMBL Gene Tree for KLF12 (if available)
    TreeFam Gene Tree for KLF12 (if available) 

    Paralogs
    for KLF12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLF12 gene
    KLF12  KLF112  KLF62  KLF102  KLF42  KLF52  KLF142  KLF162  
    KLF22  KLF152  KLF92  KLF32  KLF72  KLF132  KLF82  
    13 SIMAP similar genes for KLF12 using alignment to 2 protein entries:     KLF12_HUMAN (see all proteins):
    DKFZp313F0536    KLF7    KLF2    KLF6    KLF8    ZNF323
    ZNF702P    KLF9    KLF3    ZNF697    KLF5    KLF14
    KLF4

    KLF12 for paralogs           About GeneDecksing



    Genomic Variants
    for KLF12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7966 NCBI SNPs in KLF12 are shown (see all 7966)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1813257321,2
    		--74259678(+) CTATAA/TAATTA 1 -- ds50010--------
    rs1855886751,2
    		--74259687(+) TATTAA/GTACTA 1 -- ds50010--------
    rs1901516101,2
    		--74259745(+) TAAAAC/GACACT 1 -- ds50010--------
    rs1173381251,2
    		F,--74259787(+) ATTATT/CTGAGC 1 -- ds50011Minor allele frequency- C:0.02EA 120
    rs1818543461,2
    		--74260029(+) TTATAA/TTCATT 1 -- ds50010--------
    rs1150746541,2
    		F,--74260042(+) AATATT/CAAGCT 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1486424711,2
    		--74260097(+) GCTTTG/TTTAGA 1 -- ds50010--------
    rs1420477431,2
    		--74260099(+) TTTTTA/TAGAAT 1 -- ds50010--------
    rs1507267071,2
    		--74260301(+) TTAAAA/GGTTTA 1 -- ut310--------
    rs1869187801,2
    		--74260399(+) AAAACA/TATAAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KLF12 (74260149 - 74510149 bp, first 250kb of KLF12)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KLF12
         1 CNV: 47860

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    Disorders / Diseases
    for KLF12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KLF12 for disorders           About GeneDecksing

    OMIM gene information: 607531    OMIM disorders: --

    7 diseases for KLF12:    About MalaCards
    wegener's granulomatosis    rheumatoid arthritis    arthritis    gastric cancer
    pancreatic cancer    pancreatitis    schizophrenia

    Genetic Association Database (GAD): KLF12
    Human Genome Epidemiology (HuGE) Navigator: KLF12 (6 documents)

    Export disorders for KLF12 gene to outside databases

    Publications
    for KLF12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLF12 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with KLF12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12). (PubMed id 10704285)1, 2, 3, 9 Roth C.... Buettner R. (2000)
    2. Single nucleotide polymorphisms in the gene encoding Kruppel-like factor 7 are associated with type 2 diabetes. (PubMed id 15937668)1, 4 Kanazawa A....Maeda S. (2005)
    3. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    7. Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1. (PubMed id 11373277)1, 9 Schuierer M....Buettner R. (2001)
    8. Defining a common region of deletion at 13q21 in human cancers. (PubMed id 11433524)2, 9 Chen C.... Dong J.T. (2001)
    9. Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter. (PubMed id 11406275)1, 9 Zhu C.H....Domann F.E. (2001)
    10. Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1 Demirkan A....Schmitz G. (2012)

    External Searches for KLF12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing KLF12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11278 HGNC: 6346 AceView: KLF12 Ensembl:ENSG00000118922 euGenes: HUgn11278
    ECgene: KLF12 H-InvDB: KLF12

    Other Databases showing KLF12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KLF12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLF12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF12 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for KLF12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KLF12 gene:
    Search GeneIP for patents involving KLF12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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