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KLF11 Gene

protein-coding   GIFtS: 55
GCID: GC02P010182

Kruppel-Like Factor 11

(Previous name: TGFB inducible early growth response 2)
(Previous symbol: TIEG2)
  See KLF11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kruppel-Like Factor 111 2     FKLF12 5
TIEG21 2 3 5     MODY72 5
FKLF2 3 5     TGFB Inducible Early Growth Response 21
Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 22 3     Tieg32
TIEG-22 3     Krueppel-Like Factor 112
TGFB-Inducible Early Growth Response Protein 22 3     

External Ids:    HGNC: 118111   Entrez Gene: 84622   Ensembl: ENSG000001720597   OMIM: 6033015   UniProtKB: O149013   

Export aliases for KLF11 gene to outside databases

Previous GC identifers: GC02P010135 GC02P010100


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLF11 Gene:
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in
epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this
gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two
different isoforms have been found for this gene. (provided by RefSeq, Apr 2010)

GeneCards Summary for KLF11 Gene:
KLF11 (Kruppel-like factor 11) is a protein-coding gene. Diseases associated with KLF11 include maturity-onset diabetes of the young, type 7, and maturity-onset diabetes of the young. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF11_HUMAN, O14901
Function: Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower
degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth.
Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis

Gene Wiki entry for KLF11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005334.17  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF11 gene promoter:
         HFH-3   Max1   Sp1   Tal-1   LUN-1   LCR-F1   E47   Roaz   FOXI1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLF11 promoter sequence
   Search Chromatin IP Primers for KLF11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

KLF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF11 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P010182:  view genomic region     (about GC identifiers)

Start:
10,182,976 bp from pter      End:
10,194,963 bp from pter
Size:
11,988 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLF11_HUMAN, O14901 (See protein sequence)
Recommended Name: Krueppel-like factor 11  
Size: 512 amino acids; 55139 Da
Caution: PubMed:11087666 sequence was originally thought to originate from mouse
1 PDB 3D structure from and Proteopedia for KLF11:
1PO4 (3D)    
Secondary accessions: B4DZE7 Q9EPF4
Alternative splicing: 2 isoforms:  O14901-1   O14901-2   

Explore the universe of human proteins at neXtProt for KLF11: NX_O14901

Explore proteomics data for KLF11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KLF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001171187.1  NP_001171189.1  NP_003588.1  

    ENSEMBL proteins: 
     ENSP00000386058   ENSP00000307023   ENSP00000387866   ENSP00000388263   ENSP00000444690  
     ENSP00000442722  

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for KLF11 (5 products) 

     
    antibodies-online peptides for KLF11

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O14901

    ProtoNet protein and cluster: O14901

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: KLF11_HUMAN, O14901
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with KLF11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF11_HUMAN, O14901
    Function: Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower
    degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth.
    Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis
    Induction: By TGFB1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IDA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9748269
    GO:0044212transcription regulatory region DNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with KLF11           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Klf11):
     hematopoietic system  normal  tumorigenesis 

    Find genes that share phenotypes with KLF11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Klf11tm1Czs for KLF11

       genOway: Develop your customized and physiologically relevant rodent model for KLF11

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    miRTarBase miRNAs that target KLF11:
    hsa-mir-93-5p (MIRT028132), hsa-mir-130b-3p (MIRT020284), hsa-mir-200b-3p (MIRT024132), hsa-mir-200c-3p (MIRT021077), hsa-mir-141-3p (MIRT021660), hsa-mir-429 (MIRT016644), hsa-mir-200a-3p (MIRT020356)

    Block miRNA regulation of human, mouse, rat KLF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF11 (see all 43):
    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-106a hsa-miR-624* hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidKLF11 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF11_HUMAN, O14901: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with KLF11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLF11 About    
    See pathways by source

    SuperPathContained pathways About
    1EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway


    1 BioSystems Pathway for KLF11
        EGFR1 Signaling Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLF11
    Interactions:

        GeneGlobe Interaction Network for KLF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KLF11 (O149012, 3 ENSP000003070234) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2865198 MINT-2865179 I2D: score=3 STRING: ENSP00000244769
    MAPK1P284823, ENSP000002158324I2D: score=3 STRING: ENSP00000215832
    SIN3AQ96ST33, ENSP000003536224I2D: score=2 STRING: ENSP00000353622
    HDAC1Q135473, ENSP000003626494I2D: score=3 STRING: ENSP00000362649
    CBX5ENSP000002098754STRING: ENSP00000209875
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle IDA--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA--
    GO:0006366transcription from RNA polymerase II promoter TAS9748269
    GO:0006915apoptotic process IEA--
    GO:0008285negative regulation of cell proliferation IDA--

    Find genes that share ontologies with KLF11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF11

    2 Novoseek inferred chemical compound relationships for KLF11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 51.5 7 10207080 (2), 9748269 (2), 10762604 (1), 16131492 (1) (see all 5)
    glucose 0 2 17479246 (1), 15774581 (1)



    Find genes that share compounds with KLF11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLF11 gene (3 alternative transcripts): 
    NM_001177716.1  NM_001177718.1  NM_003597.4  

    Unigene Cluster for KLF11:

    Kruppel-like factor 11
    Hs.12229  [show with all ESTs]
    Unigene Representative Sequence: BC063286
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000401510 ENST00000305883(uc002raf.1) ENST00000448523 ENST00000440320
    ENST00000540845(uc021vdq.1) ENST00000535335(uc010yjc.2)
    miRNA
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    hsa-miR-323-3p hsa-miR-142-5p hsa-miR-106a hsa-miR-624* hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-4267
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    Additional mRNA sequence: 

    AF028008.1 AF272830.1 AJ275989.1 AK002186.1 AK289816.1 AK302880.1 AK315345.1 AK316439.1 
    BC063286.1 BC069383.1 BC074922.2 

    6 DOTS entries:

    DT.100790704  DT.95286433  DT.416694  DT.95241358  DT.100736160  DT.120954830 

    Selected AceView cDNA sequences (see all 144):

    AK002186 BF792123 AA827570 BM990922 W92007 AA317057 AI755210 W72848 
    BX384577 CB158319 CA391197 W92006 BM682480 BM999025 W76035 BU735999 
    BM726044 BQ881155 AA948039 AA923750 BM995507 BG701929 BQ002805 BC074922 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KLF11 Expression
    About this image


    KLF11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Testis (Reproductive System)
    KLF11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12229

    UniProtKB/Swiss-Prot: KLF11_HUMAN, O14901
    Tissue specificity: Ubiquitous. Higher expression in erythroid cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLF11 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf111 , 5 Kruppel-like factor 111, 5 80.9(n)1
    76.85(a)1
      12 (8.49 cM)5
    1946551  NM_178357.31  NP_848134.11 
     246513715 
    chicken
    (Gallus gallus)
    Aves KLF111 Kruppel-like factor 11 65.37(n)
    60.94(a)
      421934  NM_001006417.1  NP_001006417.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLF116
    Kruppel-like factor 11
    56(a)
    1 ↔ 1
    1(148050180-148071864)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168402 Xenopus laevis transcribed sequence with moderate similarity more 75.43(n)    BJ084655.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.94482 Transcribed sequence with moderate similarity to protein more 79.49(n)    BM156058.1 


    ENSEMBL Gene Tree for KLF11 (if available)
    TreeFam Gene Tree for KLF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF11 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  SP32  SP52  KLF62  SP22  
    KLF102  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    7 SIMAP similar genes for KLF11 using alignment to 5 protein entries:     KLF11_HUMAN (see all proteins):
    TIEG2    KLF9    KLF14    KLF16    KLF7    ZNF697
    KLF10

    Find genes that share paralogs with KLF11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF11 (see all 416)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343364201,2,,4
    C,FMaturity-onset diabetes of the young 7 (MODY7)4 pathogenic110188123(-) TGTCCG/ATGAGG 6 /T /M mis14Minor allele frequency- A:0.02NA WA 4744
    VAR_0315244
    Maturity-onset diabetes of the young 7 (MODY7)4--see VAR_0315242 A S mis40--------
    rs1219126451,2
    Cpathogenic110188503(+) AGGGAG/TCCCTC 6 A S mis10--------
    rs1430343181,2
    C--10034155(+) TTAAG-/ACTTA 
            
    ACTTT
    1 -- us2k10--------
    rs1494581121,2
    --10034204(+) CTCCGA/GGGTCT 1 -- us2k10--------
    rs1439494591,2
    C--10034213(+) CTTCAA/TGCGAG 1 -- us2k10--------
    rs1150006051,2
    F--10153582(+) CTTTCG/ATCTTA 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1886050541,2
    C--10181719(+) GATTCA/GCTCGT 1 -- us2k10--------
    rs1430295881,2
    C--10181823(+) AAAGGC/GGCAGT 1 -- us2k10--------
    rs1141939091,2
    C,F--10181936(+) ACTGCG/AGGTGA 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for KLF11 (10182976 - 10194963 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KLF11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719632CNV Deletion23290073
    esv2719633CNV Deletion23290073
    nsv508826CNV Insertion20534489
    nsv873633CNV Loss21882294
    nsv828297CNV Loss20364138
    nsv828308CNV Gain20364138

    Human Gene Mutation Database (HGMD): KLF11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF11
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603301   
    OMIM disorders: 610508  
    UniProtKB/Swiss-Prot: KLF11_HUMAN, O14901
  • Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A form of diabetes that is characterized by
    an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of
    age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for KLF11:    
    About MalaCards
    maturity-onset diabetes of the young, type 7    maturity-onset diabetes of the young    maturity-onset diabetes of the young, type 1    pancreatic cancer


    Find genes that share disorders with KLF11           About GenesLikeMe

    1 Novoseek inferred disease relationship for KLF11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 27.4 5 15300592 (5)

    Genetic Association Database (GAD): KLF11
    Human Genome Epidemiology (HuGE) Navigator: KLF11 (8 documents)

    Export disorders for KLF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF11 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with KLF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. (PubMed id 15774581)1, 2, 4, 9 Neve B.... Froguel P. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    2. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. (PubMed id 9748269)1, 2, 3, 9 Cook T.... Urrutia R. (J. Biol. Chem. 1998)
    3. Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family. (PubMed id 11087666)1, 2, 3, 9 Scohy S.... Szpirer C. (Genomics 2000)
    4. FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes. (PubMed id 10207080)1, 2, 9 Asano H.... Stamatoyannopoulos G. (Mol. Cell. Biol. 1999)
    5. Identification of minimal promoter and genetic variants of Kruppel-like factor 11 gene and association analysis with type 2 diabetes in Japanese. (PubMed id 19122346)1, 4, 9 Kuroda E....Takeda J. (Endocr. J. 2009)
    6. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    7. Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G&gt;C. (PubMed id 18505768)1, 4 GutiAcrrez-Aguilar R....Neve B. (J. Clin. Endocrinol. Metab. 2008)
    8. Association analysis of KrA1ppel-like factor 11 variants with type 2 diabetes in Pima Indians. (PubMed id 18593768)1, 4 Ma L....Baier L.J. (J. Clin. Endocrinol. Metab. 2008)
    9. The association of genetic variants in KrA1ppel-like factor 11 and Type 2 diabetes in the Japanese population. (PubMed id 18199129)1, 4 Tanahashi T....Itakura M. (Diabet. Med. 2008)
    10. The KrA1ppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people. (PubMed id 17130512)1, 4 Florez J.C....Groop L. (Diabetes 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8462 HGNC: 11811 AceView: TIEG2 Ensembl:ENSG00000172059 euGenes: HUgn8462
    ECgene: KLF11 H-InvDB: KLF11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KLF11 gene:
    Search GeneIP for patents involving KLF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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