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Aliases for KLF11 Gene

Aliases for KLF11 Gene

  • Kruppel Like Factor 11 2 3 5
  • Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 2 3 4
  • TGFB-Inducible Early Growth Response Protein 2 3 4
  • TIEG-2 3 4
  • TIEG2 3 4
  • FKLF 3 4
  • TGFB Inducible Early Growth Response 2 2
  • Krueppel-Like Factor 11 3
  • FKLF1 3
  • MODY7 3
  • Tieg3 3

External Ids for KLF11 Gene

Previous HGNC Symbols for KLF11 Gene

  • TIEG2

Previous GeneCards Identifiers for KLF11 Gene

  • GC02P010135
  • GC02P010100
  • GC02P010182

Summaries for KLF11 Gene

Entrez Gene Summary for KLF11 Gene

  • The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

GeneCards Summary for KLF11 Gene

KLF11 (Kruppel Like Factor 11) is a Protein Coding gene. Diseases associated with KLF11 include Maturity-Onset Diabetes Of The Young, Type Vii and Maturity-Onset Diabetes Of The Young. Among its related pathways are B cell receptor signaling pathway (KEGG) and TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is KLF10.

UniProtKB/Swiss-Prot for KLF11 Gene

  • Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).

Gene Wiki entry for KLF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF11 Gene

Genomics for KLF11 Gene

Regulatory Elements for KLF11 Gene

Enhancers for KLF11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F009797 1.7 FANTOM5 Ensembl ENCODE 13.5 -242.4 -242363 7.0 PKNOX1 SIN3A ARID4B DMAP1 ZNF2 SLC30A9 ZNF143 FOS DEK ZNF263 KLF11 ENSG00000233502 ADAM17 GRHL1 PIR61604 LOC105373421
GH02F010300 1.5 FANTOM5 ENCODE 13.5 +260.6 260577 5.8 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 KLF11 LOC101929882 HPCAL1 PIR41580
GH02F010131 1.6 FANTOM5 Ensembl ENCODE 11.1 +92.0 92045 6.6 PKNOX1 ARNT ZFP64 ARID4B DMAP1 FEZF1 SLC30A9 ZNF766 ZNF548 FOS LOC101929882 ENSG00000206647 KLF11 RRM2 C2orf48 TAF1B
GH02F010159 1.3 Ensembl ENCODE 11.1 +118.3 118281 3.7 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LOC101929882 KLF11 GC02M010155 ENSG00000206647 MIR4261
GH02F010269 1.3 Ensembl ENCODE 11 +228.3 228258 3.5 HDGF ATF1 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF48 SLC30A9 CBX5 LOC101929882 LOC101929691 PDIA6 HPCAL1 KLF11 PQLC3 SNORA80B LOC105373428 RN7SL66P LOC105373424
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLF11 on UCSC Golden Path with GeneCards custom track

Promoters for KLF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001649927 851 2601 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP3 SP5

Genomic Location for KLF11 Gene

Chromosome:
2
Start:
10,042,849 bp from pter
End:
10,054,836 bp from pter
Size:
11,988 bases
Orientation:
Plus strand

Genomic View for KLF11 Gene

Genes around KLF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF11 Gene

Proteins for KLF11 Gene

  • Protein details for KLF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14901-KLF11_HUMAN
    Recommended name:
    Krueppel-like factor 11
    Protein Accession:
    O14901
    Secondary Accessions:
    • B4DZE7
    • Q9EPF4

    Protein attributes for KLF11 Gene

    Size:
    512 amino acids
    Molecular mass:
    55139 Da
    Quaternary structure:
    • Interacts with SIN3A.

    Three dimensional structures from OCA and Proteopedia for KLF11 Gene

    Alternative splice isoforms for KLF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF11 Gene

Post-translational modifications for KLF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for KLF11

No data available for DME Specific Peptides for KLF11 Gene

Domains & Families for KLF11 Gene

Gene Families for KLF11 Gene

Protein Domains for KLF11 Gene

Graphical View of Domain Structure for InterPro Entry

O14901

UniProtKB/Swiss-Prot:

KLF11_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
  • Contains 3 C2H2-type zinc fingers.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with KLF11: view

Function for KLF11 Gene

Molecular function for KLF11 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).
UniProtKB/Swiss-Prot Induction:
By TGFB1.

Gene Ontology (GO) - Molecular Function for KLF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA 21171965
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9748269
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLF11: view
genes like me logo Genes that share phenotypes with KLF11: view

Human Phenotype Ontology for KLF11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for KLF11 Gene

MGI Knock Outs for KLF11:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for KLF11 Gene

Localization for KLF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF11 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2

Gene Ontology (GO) - Cellular Components for KLF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with KLF11: view

Pathways & Interactions for KLF11 Gene

genes like me logo Genes that share pathways with KLF11: view

Pathways by source for KLF11 Gene

Gene Ontology (GO) - Biological Process for KLF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IDA 21171965
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 21171965
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9748269
genes like me logo Genes that share ontologies with KLF11: view

No data available for SIGNOR curated interactions for KLF11 Gene

Drugs & Compounds for KLF11 Gene

(2) Drugs for KLF11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF11: view

Transcripts for KLF11 Gene

Unigene Clusters for KLF11 Gene

Kruppel-like factor 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF11 Gene

No ASD Table

Relevant External Links for KLF11 Gene

GeneLoc Exon Structure for
KLF11
ECgene alternative splicing isoforms for
KLF11

Expression for KLF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KLF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of KLF11 Gene:

KLF11

SOURCE GeneReport for Unigene cluster for KLF11 Gene:

Hs.12229

mRNA Expression by UniProt/SwissProt for KLF11 Gene:

O14901-KLF11_HUMAN
Tissue specificity: Ubiquitous. Higher expression in erythroid cells.
genes like me logo Genes that share expression patterns with KLF11: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KLF11 Gene

Orthologs for KLF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF11 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia KLF11 34 35
  • 83.5 (n)
rat
(Rattus norvegicus)
Mammalia Klf11 34
  • 80.93 (n)
mouse
(Mus musculus)
Mammalia Klf11 34 16 35
  • 80.9 (n)
cow
(Bos Taurus)
Mammalia KLF11 34
  • 80.81 (n)
TIEG2 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF11 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF11 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF11 34 35
  • 65.37 (n)
lizard
(Anolis carolinensis)
Reptilia KLF11 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf11 34
  • 61.6 (n)
Str.6240 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16840 34
zebrafish
(Danio rerio)
Actinopterygii klf11b 34 35
  • 58.84 (n)
klf11a 35
  • 46 (a)
OneToMany
Dr.9448 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.975 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 35
  • 24 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3473 34
Species where no ortholog for KLF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF11 Gene

ENSEMBL:
Gene Tree for KLF11 (if available)
TreeFam:
Gene Tree for KLF11 (if available)

Paralogs for KLF11 Gene

Paralogs for KLF11 Gene

(7) SIMAP similar genes for KLF11 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KLF11: view

Variants for KLF11 Gene

Sequence variations from dbSNP and Humsavar for KLF11 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121912645 Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508], Pathogenic 10,048,376(+) AGGGA(G/T)CCCTC reference, missense
rs34336420 Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508], Pathogenic 10,047,996(-) TGTCC(A/G)TGAGG reference, missense
rs145933214 Likely benign 10,047,747(+) CACGG(A/G)TGTTC reference, missense
rs550497503 Likely benign 10,043,708(+) GGCCG(A/G)CCTGC upstream-variant-2KB, utr-variant-5-prime
rs587780378 Uncertain significance 10,047,804(+) GAGGG(G/T)CTTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KLF11 Gene

Variant ID Type Subtype PubMed ID
nsv828308 CNV gain 20364138
nsv828297 CNV loss 20364138
nsv508826 CNV insertion 20534489
nsv1072388 CNV deletion 25765185
esv3589791 CNV loss 21293372
esv2719633 CNV deletion 23290073
esv2719632 CNV deletion 23290073
dgv3715n100 CNV gain 25217958
dgv1862n106 CNV deletion 24896259

Variation tolerance for KLF11 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF11 Gene

Human Gene Mutation Database (HGMD)
KLF11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF11 Gene

Disorders for KLF11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KLF11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young, type vii
  • maturity-onset diabetes of the young, type 7
maturity-onset diabetes of the young
  • mason-type diabetes
- elite association - COSMIC cancer census association via MalaCards
Search KLF11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KLF11_HUMAN
  • Maturity-onset diabetes of the young 7 (MODY7) [MIM:610508]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. {ECO:0000269 PubMed:15774581}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for KLF11

Genetic Association Database (GAD)
KLF11
Human Genome Epidemiology (HuGE) Navigator
KLF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF11
genes like me logo Genes that share disorders with KLF11: view

No data available for Genatlas for KLF11 Gene

Publications for KLF11 Gene

  1. Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. (PMID: 15774581) Neve B. … Froguel P. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 46 64
  2. Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family. (PMID: 11087666) Scohy S. … Szpirer C. (Genomics 2000) 2 3 4 22 64
  3. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. (PMID: 9748269) Cook T. … Urrutia R. (J. Biol. Chem. 1998) 2 3 4 22 64
  4. Identification of minimal promoter and genetic variants of Kruppel-like factor 11 gene and association analysis with type 2 diabetes in Japanese. (PMID: 19122346) Kuroda E. … Takeda J. (Endocr. J. 2009) 3 22 46 64
  5. FKLF, a novel Kruppel-like factor that activates human embryonic and fetal beta-like globin genes. (PMID: 10207080) Asano H. … Stamatoyannopoulos G. (Mol. Cell. Biol. 1999) 3 4 22 64

Products for KLF11 Gene

Sources for KLF11 Gene

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