Aliases for KLF11 Gene
External Ids for KLF11 Gene
Previous HGNC Symbols for KLF11 Gene
Previous GeneCards Identifiers for KLF11 Gene
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
GeneCards Summary for KLF11 Gene
KLF11 (Kruppel-Like Factor 11) is a Protein Coding gene. Diseases associated with KLF11 include maturity-onset diabetes of the young, type vii and maturity-onset diabetes of the young. Among its related pathways are EGFR1 Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is SP4.
UniProtKB/Swiss-Prot for KLF11 Gene
Transcription factor (PubMed:9748269, PubMed:10207080). Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth (PubMed:9748269, PubMed:10207080, PubMed:16131492). Represses transcription of SMAD7 which enhances TGF-beta signaling (By similarity). Induces apoptosis (By similarity).