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KLF10 Gene

protein-coding   GIFtS: 62
GCID: GC08M103661

Kruppel-Like Factor 10

(Previous name: TGFB inducible early growth response)
(Previous symbol: TIEG)
  See KLF10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Kruppel-Like Factor 101 2     TGFB Inducible Early Growth Response1
TIEG1 2 3 5     EGRA2
Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 12 3     Early Growth Response-Alpha2
EGR-alpha2 3     Krueppel-Like Factor 102
TIEG12 3     Zinc Finger Transcription Factor TIEG2
TGFB-Inducible Early Growth Response Protein 12 3     TIEG-13

External Ids:    HGNC: 118101   Entrez Gene: 70712   Ensembl: ENSG000001550907   OMIM: 6018785   UniProtKB: Q131183   
ORGUL members:         

Export aliases for KLF10 gene to outside databases

Previous GC identifers: GC08M103731 GC08M098862


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLF10 Gene:
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein
is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of
this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Jun 2013)

GeneCards Summary for KLF10 Gene:
KLF10 (Kruppel-like factor 10) is a protein-coding gene. Diseases associated with KLF10 include hemoglobinopathy, and nephroblastoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF1.

UniProtKB/Swiss-Prot: KLF10_HUMAN, Q13118
Function: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the
consensus sequence 5'-GGTGTG-3'

Gene Wiki entry for KLF10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLF10 gene promoter:
         CBF-B   Lmo2   CP1A   CP1C   CBF-C   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): KLF10 promoter sequence
   Search Chromatin IP Primers for KLF10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

KLF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLF10 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M103661:  view genomic region     (about GC identifiers)

Start:
103,661,005 bp from pter      End:
103,668,130 bp from pter
Size:
7,126 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KLF10_HUMAN, Q13118 (See protein sequence)
Recommended Name: Krueppel-like factor 10  
Size: 480 amino acids; 52555 Da
1 PDB 3D structure from and Proteopedia for KLF10:
2EPA (3D)    
Secondary accessions: A8MVH0 B2R794 L0R4P6 L0R679 O75411 Q503B2
Alternative splicing: 4 isoforms:  Q13118-1   Q13118-2   Q13118-3   Q13118-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLF10: NX_Q13118

Explore proteomics data for KLF10 at MOPED

Post-translational modifications: 

  • Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable)1
  • Ubiquitination2 at Lys223
  • Modification sites at PhosphoSitePlus

  • See KLF10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001027453.1  NP_005646.1  

    ENSEMBL proteins: 
     ENSP00000285407   ENSP00000379222  

    KLF10 Human Recombinant Protein Products:

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    Novus Biologicals KLF10 Proteins
    Novus Biologicals KLF10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for KLF10 

     
    antibodies-online proteins for KLF10 (8 products) 

     
    antibodies-online peptides for KLF10

    KLF10 Antibody Products:

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    antibodies-online antibodies for KLF10 (33 products) 

    KLF10 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for KLF10 
    antibodies-online kits for KLF10 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type
    KLF: Kruppel-like transcription factors

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q13118

    ProtoNet protein and cluster: Q13118

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: KLF10_HUMAN, Q13118
    Similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family
    Similarity: Contains 3 C2H2-type zinc fingers


    Find genes that share domains with KLF10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLF10_HUMAN, Q13118
    Function: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the
    consensus sequence 5'-GGTGTG-3'
    Induction: By TGFB1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS10816551
    GO:0005515protein binding IPI10976766
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with KLF10           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for KLF10:
     Increased gamma-H2AX phosphory  Increased resistance to MDM2 i 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Klf10):
     cellular  homeostasis/metabolism  integument  limbs/digits/tail  skeleton 
     tumorigenesis 

    Find genes that share phenotypes with KLF10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for KLF10: Klf10tm1Wkle Klf10tm1Sub

       genOway: Develop your customized and physiologically relevant rodent model for KLF10

    miRNA
    Products:
        
    miRTarBase miRNAs that target KLF10:
    hsa-mir-197-3p (MIRT004212), hsa-mir-340-5p (MIRT019621), hsa-mir-30b-5p (MIRT023455), hsa-mir-215-5p (MIRT024713), hsa-mir-98-5p (MIRT027610), hsa-mir-192-5p (MIRT026652), hsa-mir-19b-3p (MIRT031303), hsa-mir-378a-3p (MIRT043862)

    Block miRNA regulation of human, mouse, rat KLF10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF10 (see all 23):
    hsa-miR-30c hsa-miR-142-5p hsa-miR-548k hsa-miR-106a hsa-miR-30d hsa-miR-340 hsa-miR-519a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidKLF10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for KLF10
    Predesigned siRNA for gene silencing in human, mouse, rat KLF10

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): KLF10 (NM_005655)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLF10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLF10

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for KLF10 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLF10_HUMAN, Q13118: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with KLF10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLF10 About    
    See pathways by source

    SuperPathContained pathways About
    1Development TGF beta receptor signaling
    Development TGF beta receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for KLF10 (see all 54)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 GeneGo (Thomson Reuters) Pathway for KLF10
        Development TGF-beta receptor signaling


        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLF10: 
              Insulin Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Synaptic Plasticity in human mouse rat
              PPAR Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for KLF10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KLF10 (Q131181, 2, 3 ENSP000002854074) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BOP1Q141372, 3, ENSP000003041514MINT-8259161 I2D: score=2 STRING: ENSP00000304151
    LENG1Q96BZ82, 3, ENSP000002222244MINT-8259194 I2D: score=2 STRING: ENSP00000222224
    PIGCQ925352, 3, ENSP000002583244MINT-8259205 I2D: score=2 STRING: ENSP00000258324
    TNS1Q9HBL02, 3, ENSP000001718874MINT-8259241 I2D: score=2 STRING: ENSP00000171887
    SF3B3Q153932, 3MINT-8259227 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9748269
    GO:0001501skeletal system development TAS10816551
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007179transforming growth factor beta receptor signaling pathway TAS10816551

    Find genes that share ontologies with KLF10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLF10

    3 Novoseek inferred chemical compound relationships for KLF10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    homoharringtonine 76.8 2 17659279 (2)
    zinc 46.8 13 10506214 (2), 9153278 (2), 9492071 (1), 10762604 (1) (see all 8)
    estrogen 24.1 7 18483178 (3), 9492071 (1), 17729309 (1)



    Find genes that share compounds with KLF10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLF10 gene (2 alternative transcripts): 
    NM_001032282.3  NM_005655.3  

    Unigene Cluster for KLF10:

    Kruppel-like factor 10
    Hs.435001  [show with all ESTs]
    Unigene Representative Sequence: NM_001032282
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285407(uc011lhk.1) ENST00000395884(uc011lhj.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KLF10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLF10 (see all 23):
    hsa-miR-30c hsa-miR-142-5p hsa-miR-548k hsa-miR-106a hsa-miR-30d hsa-miR-340 hsa-miR-519a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidKLF10 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF10
      QuantiTect SYBR Green Assays in human, mouse, rat KLF10
      QuantiFast Probe-based Assays in human, mouse, rat KLF10

    Additional mRNA sequence: 

    AK312894.1 BC011538.1 BC095399.1 BT006634.1 HF546210.1 HF546211.1 S81439.1 U21847.1 
    X75691.1 

    5 DOTS entries:

    DT.97861928  DT.92432050  DT.121491926  DT.92432046  DT.121430175 

    Selected AceView cDNA sequences (see all 222):

    BM463731 CA976153 BQ215325 BU684687 H99660 CB145828 CB243793 AI979158 
    N24450 AL602758 AI554466 BQ029659 AA295613 AA883174 BM755411 BM787811 
    BM976714 BX107482 AA934495 CR598827 AV714317 BM843232 BQ229661 AW193350 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLF10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGTAAA
    KLF10 Expression
    About this image


    KLF10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Septum   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Neural Tube (Nervous System)
             Telencephalon
    KLF10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLF10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435001
        Pathway & Disease-focused RT2 Profiler PCR Arrays including KLF10: 
              Insulin Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              Synaptic Plasticity in human mouse rat
              PPAR Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for KLF10
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLF10
    QuantiTect SYBR Green Assays in human, mouse, rat KLF10
    QuantiFast Probe-based Assays in human, mouse, rat KLF10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLF10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for KLF10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klf101 , 5 Kruppel-like factor 101, 5 84.27(n)1
    85.59(a)1
      15 (15.15 cM)5
    218471  NM_013692.21  NP_038720.11 
     382944135 
    chicken
    (Gallus gallus)
    Aves KLF101 Kruppel-like factor 10 67.82(n)
    67.21(a)
      420255  XM_004939982.1  XP_004940039.1 
    lizard
    (Anolis carolinensis)
    Reptilia KLF106
    Kruppel-like factor 10
    68(a)
    1 ↔ 1
    4(13891911-13896454)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA982994.12   -- 73.25(n)    CA982994.1 
    zebrafish
    (Danio rerio)
    Actinopterygii FP017249.16
    Uncharacterized protein
    59(a)
    many ↔ many
    16(56271964-56272543) ENSDARG00000069685


    ENSEMBL Gene Tree for KLF10 (if available)
    TreeFam Gene Tree for KLF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLF10 gene
    KLF12  SP82  KLF172  KLF52  KLF142  SP62  KLF152  KLF22  
    KLF72  KLF82  KLF132  SP42  KLF112  SP32  SP52  KLF62  
    SP22  KLF42  SP12  KLF162  KLF122  KLF32  KLF92  SP72  
    SP92  
    3 SIMAP similar genes for KLF10 using alignment to 1 protein entry:     KLF10_HUMAN:
    KLF11    TIEG2    KLF7

    Find genes that share paralogs with KLF10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLF10 (see all 224)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27348251,2
    --98869271(-) AGGGGA/CGGGGG 1 -- us2k10--------
    rs27348241,2
    C,F,H--98869284(-) CGCCTC/TTCTAG 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1865987241,2
    --98869291(+) GGCGGG/TGCCGC 1 -- us2k10--------
    rs1923854381,2
    --98869316(+) GGCGAC/TTGCAG 1 -- us2k10--------
    rs78352701,2
    C,F--98869340(+) TGCGGA/GGGGCC 1 -- us2k14Minor allele frequency- G:0.26NA WA EA 360
    rs726851251,2
    F--103660508(+) ATTAGC/AACTTT 2 -- int11Minor allele frequency- A:0.04NA 120
    rs1909894141,2
    C--103660531(+) TGGGCA/GGATCA 2 -- int10--------
    rs1831764541,2
    --103660542(+) CTTGAC/GGTCAG 2 -- int10--------
    rs1407201341,2
    --103660553(+) GAGTTG/TGAGAC 2 -- int10--------
    rs1456182641,2
    --103660573(+) CAACAC/TGGCGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for KLF10 (103661005 - 103668130 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KLF10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33118CNV Loss17666407

    Human Gene Mutation Database (HGMD): KLF10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLF10
    DNA2.0 Custom Variant and Variant Library Synthesis for KLF10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601878    OMIM disorders: --

    4 diseases for KLF10:    
    About MalaCards
    hemoglobinopathy    nephroblastoma    pallister-hall syndrome    pancreatic cancer

    3 diseases from the University of Copenhagen DISEASES database for KLF10:
    Nephroblastoma     Pallister-Hall syndrome     Denys-Drash syndrome

    Find genes that share disorders with KLF10           About GenesLikeMe

    7 Novoseek inferred disease relationships for KLF10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreas exocrine 43.2 1 10762604 (1)
    pancreatic carcinoma 41.7 5 9492071 (1), 12173049 (1), 9443078 (1)
    breast cancer 21.8 6 9443078 (2), 9492071 (1), 15492278 (1), 15218362 (1)
    osteosarcoma 16 3 10816551 (1), 12173049 (1)
    cancer 7.06 3 18930345 (2), 9443078 (1)
    tumors 1.85 14 15218362 (5), 9492071 (1), 9443078 (1), 12841681 (1) (see all 6)
    lymphoma 0 2 15492278 (1), 15927846 (1)

    Genetic Association Database (GAD): KLF10
    Human Genome Epidemiology (HuGE) Navigator: KLF10 (6 documents)

    Export disorders for KLF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLF10 gene, integrated from 10 sources (see all 102):
    (articles sorted by number of sources associating them with KLF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters. (PubMed id 9721211)1, 2, 3, 9 Fautsch M.P.... Wieben E.D. (Genomics 1998)
    2. Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. (PubMed id 8584037)1, 2, 3 Blok L.J.... Tindall D.J. (Mol. Endocrinol. 1995)
    3. Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta- inducible early gene-1 by human seven in absentia homologue. (PubMed id 12072443)1, 2, 9 Johnsen S.A....Spelsberg T.C. (J. Biol. Chem. 2002)
    4. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. (PubMed id 8532536)1, 2, 9 Subramaniam M....Spelsberg T.C. (Nucleic Acids Res. 1995)
    5. Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha. (PubMed id 12804117)1, 2, 9 Chrisman H.R. and Tindall D.J. (DNA Cell Biol. 2003)
    6. Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors. (PubMed id 23134681)1, 2 Camacho-Vanegas O.... Martignetti J.A. (FASEB J. 2013)
    7. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    8. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    10. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7071 HGNC: 11810 AceView: TIEG Ensembl:ENSG00000155090 euGenes: HUgn7071
    ECgene: KLF10 H-InvDB: KLF10

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for KLF10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KLF10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for KLF10 gene:
    Search GeneIP for patents involving KLF10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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