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Aliases for KLF10 Gene

Aliases for KLF10 Gene

  • Kruppel-Like Factor 10 2 3
  • TIEG 3 4 6
  • Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1 3 4
  • TGFB-Inducible Early Growth Response Protein 1 3 4
  • EGR-Alpha 3 4
  • TIEG1 3 4
  • Zinc Finger Transcription Factor TIEG 3
  • TGFB Inducible Early Growth Response 2
  • Early Growth Response-Alpha 3
  • Krueppel-Like Factor 10 3
  • TIEG-1 4
  • EGRA 3

External Ids for KLF10 Gene

Previous Symbols for KLF10 Gene

  • TIEG

Summaries for KLF10 Gene

Entrez Gene Summary for KLF10 Gene

  • This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for KLF10 Gene

KLF10 (Kruppel-Like Factor 10) is a Protein Coding gene. Diseases associated with KLF10 include pancreatic cancer and hemoglobinopathy. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KLF2.

UniProtKB/Swiss-Prot for KLF10 Gene

  • Transcriptional repressor which binds to the consensus sequence 5-GGTGTG-3. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.

Gene Wiki entry for KLF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF10 Gene

Genomics for KLF10 Gene

Genomic Location for KLF10 Gene

Start:
102,648,777 bp from pter
End:
102,655,902 bp from pter
Size:
7,126 bases
Orientation:
Minus strand

Genomic View for KLF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF10 Gene

Regulatory Elements for KLF10 Gene

Proteins for KLF10 Gene

  • Protein details for KLF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13118-KLF10_HUMAN
    Recommended name:
    Krueppel-like factor 10
    Protein Accession:
    Q13118
    Secondary Accessions:
    • A8MVH0
    • B2R794
    • L0R4P6
    • L0R679
    • O75411
    • Q503B2

    Protein attributes for KLF10 Gene

    Size:
    480 amino acids
    Molecular mass:
    52555 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLF10 Gene

    Alternative splice isoforms for KLF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF10 Gene

Proteomics data for KLF10 Gene at MOPED

Post-translational modifications for KLF10 Gene

  • Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys223

Other Protein References for KLF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF10 Gene

Domains for KLF10 Gene

Gene Families for KLF10 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • KLF :Kruppel-like transcription factors

Protein Domains for KLF10 Gene

UniProtKB/Swiss-Prot:

KLF10_HUMAN
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.:
    • Q13118
Similarity:
  • Contains 3 C2H2-type zinc fingers.:
    • Q13118
genes like me logo Genes that share domains with KLF10: view

Function for KLF10 Gene

Molecular function for KLF10 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor which binds to the consensus sequence 5-GGTGTG-3. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.
UniProtKB/Swiss-Prot Induction: By TGFB1 and BMP2.

Gene Ontology (GO) - Molecular Function for KLF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10816551
GO:0005515 protein binding IPI 10976766
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with KLF10: view
genes like me logo Genes that share phenotypes with KLF10: view

Animal Models for KLF10 Gene

MGI Knock Outs for KLF10:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KLF10 Gene

Localization for KLF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLF10 Gene COMPARTMENTS Subcellular localization image for KLF10 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for KLF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with KLF10: view

Pathways for KLF10 Gene

genes like me logo Genes that share pathways with KLF10: view

Pathways by source for KLF10 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for KLF10 Gene

Gene Ontology (GO) - Biological Process for KLF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 9748269
GO:0001501 skeletal system development TAS 10816551
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 10816551
genes like me logo Genes that share ontologies with KLF10: view

Compounds for KLF10 Gene

(3) Novoseek inferred chemical compound relationships for KLF10 Gene

Compound -log(P) Hits PubMed IDs
homoharringtonine 76.8 2
zinc 46.8 10
estrogen 24.1 5
genes like me logo Genes that share compounds with KLF10: view

Transcripts for KLF10 Gene

mRNA/cDNA for KLF10 Gene

Unigene Clusters for KLF10 Gene

Kruppel-like factor 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLF10 Gene

No ASD Table

Relevant External Links for KLF10 Gene

GeneLoc Exon Structure for
KLF10
ECgene alternative splicing isoforms for
KLF10

Expression for KLF10 Gene

mRNA expression in normal human tissues for KLF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF10 Gene

This gene is overexpressed in Muscle - Skeletal (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KLF10 Gene

SOURCE GeneReport for Unigene cluster for KLF10 Gene Hs.435001

genes like me logo Genes that share expressions with KLF10: view

Orthologs for KLF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF10 36
  • 99.72 (n)
  • 99.58 (a)
KLF10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLF10 36
  • 89.7 (n)
  • 92.9 (a)
TIEG1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLF10 36
  • 91.39 (n)
  • 94.36 (a)
KLF10 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klf10 36
  • 84.27 (n)
  • 85.59 (a)
Klf10 16
Klf10 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLF10 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF10 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klf10 36
  • 83.58 (n)
  • 84.97 (a)
chicken
(Gallus gallus)
Aves KLF10 36
  • 67.82 (n)
  • 67.21 (a)
KLF10 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF10 37
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf10 36
  • 59.14 (n)
  • 53.73 (a)
zebrafish
(Danio rerio)
Actinopterygii FP017249.1 37
  • 59 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 37
  • 23 (a)
OneToMany
Species with no ortholog for KLF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF10 Gene

ENSEMBL:
Gene Tree for KLF10 (if available)
TreeFam:
Gene Tree for KLF10 (if available)

Paralogs for KLF10 Gene

Selected SIMAP similar genes for KLF10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLF10: view

Variants for KLF10 Gene

Sequence variations from dbSNP and Humsavar for KLF10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs6935 -- 102,649,114(-) ATAGG(A/C)GTTTT utr-variant-3-prime, nc-transcript-variant
rs980112 -- 102,653,285(+) ATATT(C/T)TACTT intron-variant
rs1050969 -- 102,649,502(-) TCCTT(A/G)ATTTA utr-variant-3-prime, nc-transcript-variant
rs1065641 -- 102,652,774(-) TACTC(A/C)TTTTC intron-variant
rs2471847 -- 102,653,944(-) GCCCC(A/C/T)TCCGT utr-variant-5-prime, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for KLF10 Gene

Variant ID Type Subtype PubMed ID
esv33118 CNV Loss 17666407

Relevant External Links for KLF10 Gene

HapMap Linkage Disequilibrium report
KLF10
Human Gene Mutation Database (HGMD)
KLF10

Disorders for KLF10 Gene

(3) University of Copenhagen DISEASES for KLF10 Gene

(7) Novoseek inferred disease relationships for KLF10 Gene

Disease -log(P) Hits PubMed IDs
pancreas exocrine 43.2 1
pancreatic carcinoma 41.7 3
breast cancer 21.8 5
osteosarcoma 16 2
cancer 7.06 3

Relevant External Links for KLF10

Genetic Association Database (GAD)
KLF10
Human Genome Epidemiology (HuGE) Navigator
KLF10
genes like me logo Genes that share disorders with KLF10: view

No data available for UniProtKB/Swiss-Prot for KLF10 Gene

Publications for KLF10 Gene

  1. TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters. (PMID: 9721211) Fautsch M.P. … Wieben E.D. (Genomics 1998) 2 3 4 23
  2. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. (PMID: 8532536) Subramaniam M. … Spelsberg T.C. (Nucleic Acids Res. 1995) 3 4 23
  3. Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta- inducible early gene-1 by human seven in absentia homologue. (PMID: 12072443) Johnsen S.A. … Spelsberg T.C. (J. Biol. Chem. 2002) 3 4 23
  4. Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha. (PMID: 12804117) Chrisman H.R. … Tindall D.J. (DNA Cell Biol. 2003) 3 4 23
  5. Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. (PMID: 8584037) Blok L.J. … Tindall D.J. (Mol. Endocrinol. 1995) 2 3 4

Products for KLF10 Gene

Sources for KLF10 Gene

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