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Aliases for KLF10 Gene

Aliases for KLF10 Gene

  • Kruppel Like Factor 10 2 3 5
  • Transforming Growth Factor-Beta-Inducible Early Growth Response Protein 1 3 4
  • TGFB-Inducible Early Growth Response Protein 1 3 4
  • EGR-Alpha 3 4
  • TIEG1 3 4
  • TIEG 3 4
  • Zinc Finger Transcription Factor TIEG 3
  • TGFB Inducible Early Growth Response 2
  • Early Growth Response-Alpha 3
  • Krueppel-Like Factor 10 3
  • TIEG-1 4
  • EGRA 3

External Ids for KLF10 Gene

Previous HGNC Symbols for KLF10 Gene

  • TIEG

Previous GeneCards Identifiers for KLF10 Gene

  • GC08M103731
  • GC08M103661
  • GC08M098862

Summaries for KLF10 Gene

Entrez Gene Summary for KLF10 Gene

  • This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

GeneCards Summary for KLF10 Gene

KLF10 (Kruppel Like Factor 10) is a Protein Coding gene. Diseases associated with KLF10 include Hemoglobinopathy and Pancreatic Cancer. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and core promoter sequence-specific DNA binding. An important paralog of this gene is KLF11.

UniProtKB/Swiss-Prot for KLF10 Gene

  • Transcriptional repressor which binds to the consensus sequence 5-GGTGTG-3. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.

Gene Wiki entry for KLF10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLF10 Gene

Genomics for KLF10 Gene

Regulatory Elements for KLF10 Gene

Enhancers for KLF10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G102650 1.8 FANTOM5 ENCODE dbSUPER 17.2 +0.7 737 9.3 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 KLF10 LOC107986898 RNU6-1224P ATP6V1C1 AZIN1 LOC101927245
GH08G102567 1.6 FANTOM5 Ensembl ENCODE 14.8 +87.4 87419 1.7 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 YBX1 ZNF766 GATA2 ZNF207 FOS KLF10 RNU6-1224P LOC107986898 RNU6ATAC8P UBR5 LOC105375683 ATP6V1C1 AZIN1 LOC105375684 GC08M102622
GH08G102786 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -133.5 -133499 5.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF143 FOS SP5 REST KLF10 LOC401472 AZIN1 ATP6V1C1 GC08P102794 ADI1P2
GH08G102744 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -90.0 -89997 3.1 PKNOX1 ATF1 CREB3L1 TCF12 EGR1 FOS CREM SMARCA5 NCOA1 ZEB2 KLF10 GC08P102794 ADI1P2
GH08G102781 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -126.8 -126773 2.0 PKNOX1 WRNIP1 ARID4B ZNF48 RAD21 YY1 ZNF121 RELB IKZF2 CREM KLF10 GC08P102794 ADI1P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLF10 on UCSC Golden Path with GeneCards custom track

Promoters for KLF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000228232 702 4401 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D

Genomic Location for KLF10 Gene

Chromosome:
8
Start:
102,648,777 bp from pter
End:
102,655,902 bp from pter
Size:
7,126 bases
Orientation:
Minus strand

Genomic View for KLF10 Gene

Genes around KLF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLF10 Gene

Proteins for KLF10 Gene

  • Protein details for KLF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13118-KLF10_HUMAN
    Recommended name:
    Krueppel-like factor 10
    Protein Accession:
    Q13118
    Secondary Accessions:
    • A8MVH0
    • B2R794
    • L0R4P6
    • L0R679
    • O75411
    • Q503B2

    Protein attributes for KLF10 Gene

    Size:
    480 amino acids
    Molecular mass:
    52555 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for KLF10 Gene

    Alternative splice isoforms for KLF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLF10 Gene

Post-translational modifications for KLF10 Gene

  • Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
  • Ubiquitination at posLast=223223
  • Modification sites at PhosphoSitePlus

Other Protein References for KLF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KLF10 Gene

Domains & Families for KLF10 Gene

Gene Families for KLF10 Gene

Protein Domains for KLF10 Gene

Suggested Antigen Peptide Sequences for KLF10 Gene

Graphical View of Domain Structure for InterPro Entry

Q13118

UniProtKB/Swiss-Prot:

KLF10_HUMAN :
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Sp1 C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with KLF10: view

Function for KLF10 Gene

Molecular function for KLF10 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor which binds to the consensus sequence 5-GGTGTG-3. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation.
UniProtKB/Swiss-Prot Induction:
By TGFB1 and BMP2.

Gene Ontology (GO) - Molecular Function for KLF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9748269
GO:0005515 protein binding IPI 10976766
genes like me logo Genes that share ontologies with KLF10: view
genes like me logo Genes that share phenotypes with KLF10: view

Animal Models for KLF10 Gene

MGI Knock Outs for KLF10:

Animal Model Products

miRNA for KLF10 Gene

miRTarBase miRNAs that target KLF10
Targeted motifs for KLF10 Gene
HOMER Transcription Factor Regulatory Elements motif KLF10
  • Consensus sequence: GGGGGTGTGTCC Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for KLF10 Gene

Localization for KLF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLF10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLF10 gene
Compartment Confidence
nucleus 5
extracellular 2

Gene Ontology (GO) - Cellular Components for KLF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,TAS --
genes like me logo Genes that share ontologies with KLF10: view

Pathways & Interactions for KLF10 Gene

genes like me logo Genes that share pathways with KLF10: view

Gene Ontology (GO) - Biological Process for KLF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS 9748269
GO:0001501 skeletal system development TAS 10816551
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 10816551
genes like me logo Genes that share ontologies with KLF10: view

No data available for SIGNOR curated interactions for KLF10 Gene

Drugs & Compounds for KLF10 Gene

(3) Drugs for KLF10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KLF10: view

Transcripts for KLF10 Gene

mRNA/cDNA for KLF10 Gene

Unigene Clusters for KLF10 Gene

Kruppel-like factor 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLF10 Gene

No ASD Table

Relevant External Links for KLF10 Gene

GeneLoc Exon Structure for
KLF10
ECgene alternative splicing isoforms for
KLF10

Expression for KLF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLF10 Gene

This gene is overexpressed in Muscle - Skeletal (x5.6).

Protein differential expression in normal tissues from HIPED for KLF10 Gene

This gene is overexpressed in Tlymphocyte (40.0) and Peripheral blood mononuclear cells (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KLF10 Gene



Protein tissue co-expression partners for KLF10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLF10 Gene:

KLF10

SOURCE GeneReport for Unigene cluster for KLF10 Gene:

Hs.435001

Evidence on tissue expression from TISSUES for KLF10 Gene

  • Nervous system(4.6)
  • Eye(4.1)
  • Muscle(3.3)
  • Liver(2.4)
  • Lung(2.1)
  • Heart(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with KLF10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLF10 Gene

Orthologs for KLF10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KLF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLF10 34 35
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia TIEG1 35
  • 92 (a)
OneToOne
KLF10 34
  • 89.7 (n)
dog
(Canis familiaris)
Mammalia KLF10 35 34
  • 91.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Klf10 34 16 35
  • 84.27 (n)
rat
(Rattus norvegicus)
Mammalia Klf10 34
  • 83.58 (n)
oppossum
(Monodelphis domestica)
Mammalia KLF10 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLF10 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLF10 35 34
  • 67.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLF10 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia klf10 34
  • 59.14 (n)
zebrafish
(Danio rerio)
Actinopterygii FP017249.1 35
  • 59 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7373 35
  • 23 (a)
OneToMany
Species where no ortholog for KLF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KLF10 Gene

ENSEMBL:
Gene Tree for KLF10 (if available)
TreeFam:
Gene Tree for KLF10 (if available)

Paralogs for KLF10 Gene

Paralogs for KLF10 Gene

(3) SIMAP similar genes for KLF10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KLF10: view

Variants for KLF10 Gene

Sequence variations from dbSNP and Humsavar for KLF10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000275005 -- 102,655,249(+) CACTC(C/T)TCCCC intron-variant, upstream-variant-2KB
rs1000331445 -- 102,655,477(+) CATGG(C/T)TGATG intron-variant, upstream-variant-2KB
rs1000435798 -- 102,649,336(+) TATCT(A/T)AGAGT nc-transcript-variant, utr-variant-3-prime
rs1000635523 -- 102,654,249(+) GCCGC(A/G)GGCGC intron-variant, upstream-variant-2KB
rs1000768482 -- 102,648,531(+) AAAAA(A/T)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KLF10 Gene

Variant ID Type Subtype PubMed ID
esv33118 CNV loss 17666407
nsv1075158 CNV deletion 25765185
nsv1126857 CNV deletion 24896259

Variation tolerance for KLF10 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLF10 Gene

Human Gene Mutation Database (HGMD)
KLF10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLF10 Gene

Disorders for KLF10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KLF10 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hemoglobinopathy
  • hemoglobinopathies
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search KLF10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLF10

Genetic Association Database (GAD)
KLF10
Human Genome Epidemiology (HuGE) Navigator
KLF10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLF10
genes like me logo Genes that share disorders with KLF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLF10 Gene

Publications for KLF10 Gene

  1. TGFbeta-inducible early gene (TIEG) also codes for early growth response alpha (EGRalpha): evidence of multiple transcripts from alternate promoters. (PMID: 9721211) Fautsch M.P. … Wieben E.D. (Genomics 1998) 2 3 4 22 64
  2. Identification and characterization of a consensus DNA binding element for the zinc finger transcription factor TIEG/EGRalpha. (PMID: 12804117) Chrisman H.R. … Tindall D.J. (DNA Cell Biol. 2003) 3 4 22 64
  3. Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta- inducible early gene-1 by human seven in absentia homologue. (PMID: 12072443) Johnsen S.A. … Spelsberg T.C. (J. Biol. Chem. 2002) 3 4 22 64
  4. Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation. (PMID: 8584037) Blok L.J. … Tindall D.J. (Mol. Endocrinol. 1995) 2 3 4 64
  5. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. (PMID: 8532536) Subramaniam M. … Spelsberg T.C. (Nucleic Acids Res. 1995) 3 4 22 64

Products for KLF10 Gene

Sources for KLF10 Gene

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