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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLC4 Gene

protein-coding   GIFtS: 55
GCID: GC06P043008

Kinesin Light Chain 4

(Previous name: kinesin-like 8)
(Previous symbol: KNSL8)
  Search for KLC4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Light Chain 41 2
KNSL81 2 3
Kinesin-Like 81 2
Kinesin-Like Protein 82 3
KLC 42 3
bA387M24.32

External Ids:    HGNC: 216241   Entrez Gene: 899532   Ensembl: ENSG000001371717   UniProtKB: Q9NSK03   

Export aliases for KLC4 gene to outside databases

Previous GC identifers: GC06P043136 GC06P042744


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KLC4 Gene: 
KLC4 (kinesin light chain 4) is a protein-coding gene. Among its related super-pathways are Immune System and Kinesins. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is KLC2.

UniProtKB/Swiss-Prot: KLC4_HUMAN, Q9NSK0
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity
(By similarity)

Gene Wiki entry for KLC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLC4 gene promoter:
         E2F-3a   E2F-4   RFX1   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLC4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLC4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

KLC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLC4 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P043008:  view genomic region     (about GC identifiers)

Start:
43,008,515 bp from pter      End:
43,042,837 bp from pter
Size:
34,323 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLC4_HUMAN, Q9NSK0 (See protein sequence)
Recommended Name: Kinesin light chain 4  
Size: 619 amino acids; 68640 Da
Subunit: Oligomeric complex composed of two heavy chains and two light chains (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Sequence caution: Sequence=BAC86788.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: B3KNY4 B3KPI3 B3KSQ3 Q66K28 Q96EG6
Alternative splicing: 4 isoforms:  Q9NSK0-1   Q9NSK0-2   Q9NSK0-3   Q9NSK0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLC4: NX_Q9NSK0

Explore proteomics data for KLC4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NSK0

  • KLC4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLC4 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_612352.1  NP_958929.1  NP_958930.1  NP_958931.1  

    ENSEMBL proteins: 
     ENSP00000418759   ENSP00000340221   ENSP00000395806   ENSP00000419784   ENSP00000417652  
     ENSP00000410358   ENSP00000259708   ENSP00000419102   ENSP00000418031   ENSP00000420144  
     ENSP00000418546   ENSP00000377620   ENSP00000419634   ENSP00000417620   ENSP00000377622  
    Reactome Protein details: Q9NSK0
    Human Recombinant Protein Products for KLC4: 
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    Novus Biologicals KLC4 Protein
    Novus Biologicals KLC4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLC4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005871kinesin complex IEA--
    GO:0005874microtubule IEA--

    KLC4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5/7 InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR015792 Kinesin_light_repeat
     IPR002151 Kinesin_light
     IPR015390 Rabaptin_Rab5-bd_dom
     IPR013105 TPR_2

    Graphical View of Domain Structure for InterPro Entry Q9NSK0

    ProtoNet protein and cluster: Q9NSK0

    1 Blocks protein domain: IPB002151 Kinesin light chain

    UniProtKB/Swiss-Prot: KLC4_HUMAN, Q9NSK0
    Similarity: Belongs to the kinesin light chain family
    Similarity: Contains 7 TPR repeats


    KLC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLC4_HUMAN, Q9NSK0
    Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
    The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity
    (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding ----
         
    KLC4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLC4:
     Decreased melanin production 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KLC4 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidKLC4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLC4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLC4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2MHC class II antigen presentation
    MHC class II antigen presentation0.32
    Kinesins0.32
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    4Salmonella infection
    Salmonella infection
    5Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/6        Reactome Pathways for KLC4 (see all 6)
        Hemostasis
    Factors involved in megakaryocyte development and platelet production
    Adaptive Immune System
    Immune System
    Kinesins


    1         Kegg Pathway  (Kegg details for KLC4):
        Salmonella infection


    KLC4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for KLC4 (Q9NSK02, 3 ENSP000002597084) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384322, 3, ENSP000002403164MINT-2877853 I2D: score=3 STRING: ENSP00000240316
    YWHAZP631042, 3, ENSP000003095034MINT-51025 I2D: score=4 STRING: ENSP00000309503
    TCEA2Q155603, ENSP000003435154I2D: score=1 STRING: ENSP00000343515
    YWHAEP622583, ENSP000002643354I2D: score=1 STRING: ENSP00000264335
    YWHAHQ049173, ENSP000002489754I2D: score=1 STRING: ENSP00000248975
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLC4

    Search CenterWatch for drugs/clinical trials and news about KLC4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLC4 gene (4 alternative transcripts): 
    NM_138343.2  NM_201521.1  NM_201522.1  NM_201523.1  

    Unigene Cluster for KLC4:

    Kinesin light chain 4
    Hs.655123  [show with all ESTs]
    Unigene Representative Sequence: AK055293
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000467906(uc003otr.1 uc003otv.1 uc011dvd.1) ENST00000347162
    ENST00000453940 ENST00000479632 ENST00000470728 ENST00000458460(uc003otu.3)
    ENST00000259708(uc003otw.1 uc003oty.1) ENST00000472792 ENST00000479388
    ENST00000460283 ENST00000481499 ENST00000394056(uc003otx.1) ENST00000481888
    ENST00000472172 ENST00000468114 ENST00000469987 ENST00000463063 ENST00000463168

    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate KLC4 (see all 11):
    hsa-miR-4324 hsa-miR-492 hsa-miR-3653 hsa-miR-3921 hsa-miR-3667-3p hsa-miR-544b hsa-miR-548t hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidKLC4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK055293.1 AK056393.1 AK094102.1 AK127894.1 AK297433.1 AL162078.1 BC012357.1 BC080637.1 
    BC103727.1 BX640717.1 

    19 DOTS entries:

    DT.75103454  DT.95117659  DT.97815284  DT.101983590  DT.106584  DT.75101705  DT.121375032  DT.101983589 
    DT.40231072  DT.100739598  DT.95315793  DT.97781150  DT.121375015  DT.92432263  DT.92432267  DT.95117655 
    DT.95117665  DT.95176286  DT.40125059 

    24/186 AceView cDNA sequences (see all 186):

    AA682343 AL162078 BU541349 AK127894 AI929528 BQ894804 BG753171 AL702524 
    NM_201521 BC012357 BQ771889 AI017685 BQ072813 NM_201522 BQ072463 CF242910 
    NM_201523 BQ719078 CB305435 AI929486 BQ072431 CA394980 NM_138343 AW083465 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for KLC4 (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^
    SP1:                                      -                 -     -                                                                 -                           
    SP2:              -     -     -     -     -     -           -     -                                                                 -                           
    SP3:                                -     -     -           -     -                                                                 -                           
    SP4:              -     -     -     -     -     -     -     -     -                                                                                             
    SP5:              -     -     -     -     -     -           -     -     -                                                                                       

    ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for KLC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLC4 expression in normal human tissues (normalized intensities)      KLC4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTCACTT
    KLC4 Expression
    About this image


    KLC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
             ileum   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   

    See KLC4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLC4

    SOURCE GeneReport for Unigene cluster: Hs.655123
        SABiosciences Custom PCR Arrays for KLC4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLC4 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klc41 , 5 kinesin light chain 41, 5 87.83(n)1
    94.35(a)1
      17 (22.90 cM)5
    747641  NM_029091.21  NP_083367.11 
     466306315 
    chicken
    (Gallus gallus)
    Aves KLC41 kinesin light chain 4 74.54(n)
    78.87(a)
      769965  XM_001233278.2  XP_001233279.2 
    zebrafish
    (Danio rerio)
    Actinopterygii klc1b1 kinesin light chain 1b 71.06(n)
    76.5(a)
      335499  NM_199954.1  NP_956248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klc6
    Kinesin light chain
    67(a)
    1 → many
    3L(12739716-12743156)
    worm
    (Caenorhabditis elegans)
    Secernentea klc-26
    klc-16
    Protein KLC-1, isoform b
    57(a)
    41(a)
    many ↔ many
    many ↔ many
    V(5575410-5581713)
    IV(11083735-11086053)


    ENSEMBL Gene Tree for KLC4 (if available)
    TreeFam Gene Tree for KLC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLC4 gene
    KLC22  ENSG000002565002  KLC32  KLC12  NPHP32  
    5 SIMAP similar genes for KLC4 using alignment to 9 protein entries:     KLC4_HUMAN (see all proteins):
    KNS2    KLC1    KLC3    KLC2    NPHP3

    KLC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/353 SNPs in KLC4 are shown (see all 353)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617433331,2
    C,F--43029249(+) AGGCCA/GTGAGG 8 H R mis13Minor allele frequency- G:0.00NS WA NA 4698
    rs1995667971,2
    --43029250(+) GGCCAC/TGAGGA 8 H syn10--------
    rs115589791,2,4
    C,F--43029288(+) GCTTCG/ACCGTT 8 /H /R mis1 ese35Minor allele frequency- A:0.02NA NS EA EU 5403
    rs1415463111,2
    F--43029313(+) GAGCTC/TGGGCT 8 L syn11Minor allele frequency- T:0.00NA 4520
    rs1494861571,2
    --43029593(+) TGATTC/TGGTAT 4 -- int10--------
    rs1880582721,2
    --43029673(+) AGAGGG/TTATAA 4 -- int10--------
    rs1438462671,2
    --43029769(+) ATGCCA/GTAAAC 4 -- int10--------
    rs1915958621,2
    --43029853(+) GTGAAC/TAGCAA 4 -- int10--------
    rs1841153381,2
    --43030139(+) CACCAC/TGCCCG 4 -- int10--------
    rs1872586681,2
    --43030186(+) ACCATA/GTTGGC 4 -- int10--------

    HapMap Linkage Disequilibrium report for KLC4 (43008515 - 43042837 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KLC4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2446917CNV Deletion19546169
    esv2731992CNV Deletion23290073
    nsv462930CNV Loss19166990
    nsv437509CNV Loss16327808
    nsv462927CNV Loss19166990
    esv275497CNV Gain+Loss21479260

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLC4 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with KLC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 89953 HGNC: 21624 AceView: KNSL8 Ensembl:ENSG00000137171 euGenes: HUgn89953
    ECgene: KLC4 Kegg: 89953 H-InvDB: KLC4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLC4 gene:
    Search GeneIP for patents involving KLC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in KLC4 promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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