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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KLC4 Gene

protein-coding GIFtS: 52
GCID: GC06P043008

kinesin light chain 4

(Previous name: kinesin-like 8 )
(Previous symbol: KNSL8)

Explore 2 diseases affiliated with
KLC4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kinesin Light Chain 4¹ ²
KNSL8¹ ² ³
BA387M24.3¹
Kinesin-Like 8¹ ²
Kinesin-Like Protein 8² ³
KLC 4² ³

External Ids:	HGNC: 21624¹	Entrez Gene: 89953²	Ensembl: ENSG00000137171⁷	UniProtKB: Q9NSK0³

Export aliases for KLC4 gene to outside databases

Previous GC identifers: GC06P043136 GC06P042744

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KLC4_HUMAN, Q9NSK0

Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The

light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By

similarity)

Gene Wiki entry for KLC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLC4 gene promoter:
E2F-3a E2F-4 RFX1 E2F-1 E2F-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLC4 promoter sequence

Search SABiosciences Chromatin IP Primers for KLC4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLC4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.1

KLC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLC4 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P043008: view genomic region (about GC identifiers)

Start:	43,008,515 bp from pter	End:	43,042,837 bp from pter
Size:	34,323 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLC4_HUMAN, Q9NSK0 (See protein sequence)

Recommended Name: Kinesin light chain 4

Size: 619 amino acids; 68640 Da

Subunit: Oligomeric complex composed of two heavy chains and two light chains (By similarity)

Subcellular location: Cytoplasm, cytoskeleton (Probable)

Sequence caution: Sequence=BAC86788.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Secondary accessions: B3KNY4 B3KPI3 B3KSQ3 Q66K28 Q96EG6

Alternative splicing: 4 isoforms: Q9NSK0-1 Q9NSK0-2 Q9NSK0-3 Q9NSK0-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLC4: NX_Q9NSK0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NSK0

KLC4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_612352.1 NP_958929.1 NP_958930.1 NP_958931.1

ENSEMBL proteins:

ENSP00000418759 ENSP00000340221 ENSP00000395806 ENSP00000419784 ENSP00000417652

ENSP00000410358 ENSP00000259708 ENSP00000418031 ENSP00000419102 ENSP00000420144

ENSP00000418546 ENSP00000377620 ENSP00000419634 ENSP00000417620 ENSP00000377622

Reactome Protein details: Q9NSK0
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for KLC4
	Novus Biologicals KLC4 Protein Novus Biologicals KLC4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KLC4

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005871	kinesin complex	IEA	--
GO:0005874	microtubule	IEA	--

KLC4 for ontologies About GeneDecksing

KLC4 Antibody Products:

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	ThermoFisher Antibodies for KLC4

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	Uscn ELISAs and CLIAs for KLC4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLC4 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR011990 TPR-like_helical

IPR015792 Kinesin_light_repeat

IPR002151 Kinesin_light

IPR015390 Rabaptin_Rab5-bd_dom

IPR013105 TPR_2

Graphical View of Domain Structure for InterPro Entry Q9NSK0

ProtoNet protein and cluster: Q9NSK0

1 Blocks protein family: IPB002151 Kinesin light chain

UniProtKB/Swiss-Prot: KLC4_HUMAN, Q9NSK0

Similarity: Belongs to the kinesin light chain family

Similarity: Contains 7 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KLC4_HUMAN, Q9NSK0

Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The

light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By

similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): KLC4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLC4
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate KLC4 (see all 11):
		hsa-miR-4324 hsa-miR-492 hsa-miR-3653 hsa-miR-3921 hsa-miR-3667-3p hsa-miR-544b hsa-miR-548t hsa-miR-3658

		SwitchGear 3'UTR luciferase reporter plasmid: KLC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLC4 (see all 7) OriGene shRNA RFP: KLC4 OriGene siRNA: KLC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLC4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for KLC4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLC4 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLC4 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): KLC4 (NM_201523)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLC4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KLC4
		Search LifeMap BioReagents cell lines for KLC4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLC4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003777	microtubule motor activity	IEA	--

KLC4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KLC4:

Decreased melanin production

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Kinesins

Kinesins

1.00

Kinesins move along microtubules consuming ATP

0.95

MHC class II antigen presentation

MHC class II antigen presentation

1.00

Transport of antigen loaded MHC II molecules to surface

0.59

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

1.00

Platelet activation, signaling and aggregation

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for KLC4 (see all 8)

	Hemostasis
	Adaptive Immune System
	Transport of antigen loaded MHC II molecules to surface
	Kinesins move along microtubules consuming ATP
	Factors involved in megakaryocyte development and platelet production

KLC4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KLC4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/34 Interacting proteins for KLC4 (Q9NSK0^{2, 3} ENSP00000259708⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COIL	P38432²^,³, ENSP00000240316⁴	MINT-2877853 I2D: score=3 STRING: ENSP00000240316
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-51025 I2D: score=4 STRING: ENSP00000309503
TCEA2	Q15560³, ENSP00000343515⁴	I2D: score=1 STRING: ENSP00000343515
YWHAE	P62258³, ENSP00000264335⁴	I2D: score=1 STRING: ENSP00000264335
YWHAH	Q04917³, ENSP00000248975⁴	I2D: score=1 STRING: ENSP00000248975

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLC4
Search CenterWatch for drugs/clinical trials and news about KLC4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLC4 gene (4 alternative transcripts):

NM_138343.2 NM_201521.1 NM_201522.1 NM_201523.1

Unigene Cluster for KLC4:

Kinesin light chain 4

Hs.655123 [show with all ESTs]

Unigene Representative Sequence: AK055293

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000467906(uc003otr.1 uc003otv.1 uc011dvd.1) ENST00000347162

ENST00000453940 ENST00000479632 ENST00000470728 ENST00000458460(uc003otu.3)

ENST00000259708(uc003otw.1 uc003oty.1) ENST00000479388 ENST00000472792

ENST00000460283 ENST00000481499 ENST00000394056(uc003otx.1) ENST00000481888

ENST00000472172 ENST00000468114 ENST00000469987 ENST00000463063 ENST00000463168

miRNA Products:		OriGene 3'-UTR Clone (see all 4): KLC4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLC4
		8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate KLC4 (see all 11):
		hsa-miR-4324 hsa-miR-492 hsa-miR-3653 hsa-miR-3921 hsa-miR-3667-3p hsa-miR-544b hsa-miR-548t hsa-miR-3658

		SwitchGear 3'UTR luciferase reporter plasmid: KLC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KLC4 (see all 7) OriGene shRNA RFP: KLC4 OriGene siRNA: KLC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KLC4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KLC4 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KLC4 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): KLC4 (NM_201523)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLC4

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KLC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLC4

Additional cDNA sequence:

AK055293.1 AK056393.1 AK094102.1 AK127894.1 AK297433.1 AL162078.1 BC012357.1 BC080637.1

BC103727.1 BX640717.1

19 DOTS entries:

DT.75103454 DT.95117659 DT.97815284 DT.101983590 DT.106584 DT.75101705 DT.121375032 DT.101983589

DT.40231072 DT.100739598 DT.95315793 DT.97781150 DT.121375015 DT.92432263 DT.92432267 DT.95117655

DT.95117665 DT.95176286 DT.40125059

24/186 AceView cDNA sequences (see all 186):

AI929486 AI076952 BU541349 AK094102 BQ072431 AI929528 BQ688778 NM_201522

AK127894 AW207184 NM_138343 NM_201523 BG753171 AW204073 AA682343 BQ719078

BC012357 BM711543 BQ948563 AI041608 BQ070342 BM757199 BQ071076 AW083465

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for KLC4 (see all 14) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10	^	11	^	12	^
SP1:													-						-		-																						-
SP2:					-		-		-		-		-		-				-		-																						-
SP3:											-		-		-				-		-																						-
SP4:					-		-		-		-		-		-		-		-		-
SP5:					-		-		-		-		-		-				-		-		-

ExUns:	13	^	14	^	15	^	16	^	17	^	18
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KLC4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTCACTT

About this image
See KLC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLC4

SOURCE GeneReport for Unigene cluster: Hs.655123

SABiosciences Custom PCR Arrays for KLC4

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLC4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLC4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KLC4 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KLC4¹	kinesin light chain 4	74.54(n) 78.87(a)		769965 XM_001233278.2 XP_001233279.2
lizard (Anolis carolinensis)	Reptilia	KLC4⁶ KLC3⁶	--	76(a) 69(a)	1 ↔ 1 possible ortholog	2(144120921-144163040) AAWZ02038453(1352-6180)
zebrafish (Danio rerio)	Actinopterygii	klc1b¹	kinesin light chain 1b	71.06(n) 76.5(a)		335499 NM_199954.1 NP_956248.1
fruit fly (Drosophila melanogaster)	Insecta	Klc⁶	Kinesin light chain	65(a)	1 → many	3L(12739716-12743156)
worm (Caenorhabditis elegans)	Secernentea	klc-2⁶ klc-1⁶	Kinesin Light Chain family member (klc-1)	57(a) 42(a)	1 ↔ many possible ortholog	V(5575394-5581697) IV(11084084-11086032)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G10840⁶ AT2G31240⁶ (see all 6)	tetratricopeptide repeat-containing protein (see all 6)	9(a) 9(a) (see all 6)	possible ortholog possible ortholog (see all 6)	4(6656516-6659265) 2(13317415-13319560)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	tetratricopeptide repeat containing protein, putat... tetratricopeptide repeat domain containing protein... (see all 4)	8(a) 8(a) (see all 4)	possible ortholog possible ortholog (see all 4)	2(35212441-35215229) 2(29281836-29285765)

ENSEMBL Gene Tree for KLC4 (if available)
TreeFam Gene Tree for KLC4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for KLC4 gene

KLC2² ENSG00000256500² KLC3² KLC1² NPHP3²

5 SIMAP similar genes for KLC4 using alignment to 9 protein entries: KLC4_HUMAN (see all proteins):

KNS2 KLC1 KLC3 KLC2 NPHP3

KLC4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61743333^1,2	C,F,	--	43029249(+)	`AGGCCA/GTGAGG`	8	H R	mis¹		3		NS WA NA	4698
rs199566797^1,2		--	43029250(+)	`GGCCAC/TGAGGA`	8	H	syn¹		0	--	--	--	--
rs11558979^1,2	C,F,	--	43029288(+)	`GCTTCG/ACCGTT`	8	/H /R	mis¹ ese³		5		NA NS EA EU	5403
rs141546311^1,2	F	--	43029313(+)	`GAGCTC/TGGGCT`	8	L	syn¹		1		NA	4520
rs149486157^1,2		--	43029593(+)	`TGATTC/TGGTAT`	4	--	int¹		0	--	--	--	--
rs188058272^1,2		--	43029673(+)	`AGAGGG/TTATAA`	4	--	int¹		0	--	--	--	--
rs143846267^1,2		--	43029769(+)	`ATGCCA/GTAAAC`	4	--	int¹		0	--	--	--	--
rs191595862^1,2		--	43029853(+)	`GTGAAC/TAGCAA`	4	--	int¹		0	--	--	--	--
rs184115338^1,2		--	43030139(+)	`CACCAC/TGCCCG`	4	--	int¹		0	--	--	--	--
rs187258668^1,2		--	43030186(+)	`ACCATA/GTTGGC`	4	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for KLC4 (43008515 - 43042837 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for KLC4
1 CNV: 99518

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KLC4

DNA2.0 Custom Variant and Variant Library Synthesis for KLC4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

KLC4 for disorders About GeneDecksing

2 diseases for KLC4: About MalaCards

ataxia neuronitis

Export disorders for KLC4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KLC4 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with KLC4)

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A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89953	HGNC: 21624	AceView: KNSL8	Ensembl:ENSG00000137171	euGenes: HUgn89953
ECgene: KLC4	H-InvDB: KLC4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KLC4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KLC4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KLC4 gene:
Search GeneIP for patents involving KLC4

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kinesin light chain 4

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kinesin light chain 4

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