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Aliases for KLC4 Gene

Aliases for KLC4 Gene

  • Kinesin Light Chain 4 2 3 5
  • Kinesin-Like Protein 8 3 4
  • KNSL8 3 4
  • Kinesin-Like 8 2
  • BA387M24.3 3
  • KLC 4 4

External Ids for KLC4 Gene

Previous HGNC Symbols for KLC4 Gene

  • KNSL8

Previous GeneCards Identifiers for KLC4 Gene

  • GC06P043136
  • GC06P043008
  • GC06P042744

Summaries for KLC4 Gene

GeneCards Summary for KLC4 Gene

KLC4 (Kinesin Light Chain 4) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Golgi-to-ER retrograde transport. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is KLC2.

UniProtKB/Swiss-Prot for KLC4 Gene

  • Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Gene Wiki entry for KLC4 Gene

Additional gene information for KLC4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLC4 Gene

Genomics for KLC4 Gene

Regulatory Elements for KLC4 Gene

Enhancers for KLC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H043266 2 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +232.7 232676 13.1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 POLH ZNF318 GTPBP2 POLR1C RPS2P29 ABCC10 XPO5 CUL7 UBR2 RRP36
GH06H042901 1.5 Ensembl ENCODE dbSUPER 11.2 -137.7 -137727 3.3 FOXA2 ARNT ZFP64 ARID4B DMAP1 ZNF2 YY1 TCF12 SLC30A9 ZNF143 RPL7L1 PEX6 CNPY3 ENSG00000231113 PPP2R5D KLC4 RN7SL403P CUL7 KLHDC3 MEA1
GH06H043119 1.3 Ensembl ENCODE dbSUPER 11.7 +82.6 82613 8.7 ZBTB21 ZIC2 ZNF324 ZNF121 ZFHX2 GLIS2 POLR2A ZBTB48 EGR1 SCRT2 CUL7 PTK7 KLC4 RN7SL403P PPP2R5D ENSG00000231113 CNPY3 DNPH1 KLHDC3 MEA1
GH06H042928 1.4 ENCODE dbSUPER 10.7 -110.0 -109989 5.6 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZNF610 PEX6 ZNF318 POLH XPO5 RRP36 CUL7 GTPBP2 ABCC10 PPP2R5D RPS2P29
GH06H043141 1.3 Ensembl ENCODE 11.4 +102.7 102686 3.6 HDGF ARID4B SIN3A ZNF2 ZNF143 SP5 MXD4 REST ZNF592 KAT8 CUL7 DNPH1 KLC4 RN7SL403P KLHDC3 MEA1 PPP2R5D RPL7L1 SRF PIR51341
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLC4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KLC4 Gene

Genomic Locations for KLC4 Gene
chr6:43,040,777-43,075,099
(GRCh38/hg38)
Size:
34,323 bases
Orientation:
Plus strand
chr6:43,008,515-43,042,837
(GRCh37/hg19)

Genomic View for KLC4 Gene

Genes around KLC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLC4 Gene

Proteins for KLC4 Gene

  • Protein details for KLC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSK0-KLC4_HUMAN
    Recommended name:
    Kinesin light chain 4
    Protein Accession:
    Q9NSK0
    Secondary Accessions:
    • B3KNY4
    • B3KPI3
    • B3KSQ3
    • B4DME9
    • Q66K28
    • Q96EG6

    Protein attributes for KLC4 Gene

    Size:
    619 amino acids
    Molecular mass:
    68640 Da
    Quaternary structure:
    • Oligomeric complex composed of two heavy chains and two light chains.
    SequenceCaution:
    • Sequence=BAC86788.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLC4 Gene

Post-translational modifications for KLC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLC4 Gene

Domains & Families for KLC4 Gene

Gene Families for KLC4 Gene

Suggested Antigen Peptide Sequences for KLC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSK0

UniProtKB/Swiss-Prot:

KLC4_HUMAN :
  • Belongs to the kinesin light chain family.
Family:
  • Belongs to the kinesin light chain family.
genes like me logo Genes that share domains with KLC4: view

Function for KLC4 Gene

Molecular function for KLC4 Gene

UniProtKB/Swiss-Prot Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Phenotypes From GWAS Catalog for KLC4 Gene

Gene Ontology (GO) - Molecular Function for KLC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 15324660
genes like me logo Genes that share ontologies with KLC4: view

Phenotypes for KLC4 Gene

genes like me logo Genes that share phenotypes with KLC4: view

miRNA for KLC4 Gene

miRTarBase miRNAs that target KLC4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLC4 Gene

Localization for KLC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLC4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLC4 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
mitochondrion 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KLC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KLC4: view

Pathways & Interactions for KLC4 Gene

genes like me logo Genes that share pathways with KLC4: view

Gene Ontology (GO) - Biological Process for KLC4 Gene

None

No data available for SIGNOR curated interactions for KLC4 Gene

Drugs & Compounds for KLC4 Gene

No Compound Related Data Available

Transcripts for KLC4 Gene

Unigene Clusters for KLC4 Gene

Kinesin light chain 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLC4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - - - -
SP13: - - - - -
SP14:

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KLC4 Gene

GeneLoc Exon Structure for
KLC4
ECgene alternative splicing isoforms for
KLC4

Expression for KLC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLC4 Gene

This gene is overexpressed in Liver (x4.2).

Protein differential expression in normal tissues from HIPED for KLC4 Gene

This gene is overexpressed in Heart (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLC4 Gene



Protein tissue co-expression partners for KLC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLC4 Gene:

KLC4

SOURCE GeneReport for Unigene cluster for KLC4 Gene:

Hs.655123

Evidence on tissue expression from TISSUES for KLC4 Gene

  • Nervous system(4.9)
  • Intestine(4.6)
  • Adrenal gland(4.4)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with KLC4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLC4 Gene

Orthologs for KLC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLC4 33 34
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia KLC4 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLC4 33 34
  • 90.69 (n)
cow
(Bos Taurus)
Mammalia KLC4 33 34
  • 89.02 (n)
rat
(Rattus norvegicus)
Mammalia Klc4 33
  • 87.94 (n)
mouse
(Mus musculus)
Mammalia Klc4 33 16 34
  • 87.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLC4 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLC4 33 34
  • 74.85 (n)
lizard
(Anolis carolinensis)
Reptilia KLC4 34
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii klc1b 33
  • 71 (n)
klc4 34 34
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Klc 34
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klc-2 34
  • 58 (a)
ManyToMany
klc-1 34
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
OneToMany
Species where no ortholog for KLC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLC4 Gene

ENSEMBL:
Gene Tree for KLC4 (if available)
TreeFam:
Gene Tree for KLC4 (if available)

Paralogs for KLC4 Gene

Paralogs for KLC4 Gene

genes like me logo Genes that share paralogs with KLC4: view

Variants for KLC4 Gene

Sequence variations from dbSNP and Humsavar for KLC4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000433413 -- 43,072,965(+) CCGGG(A/G)TAAGT splice-donor-variant
rs1000539582 -- 43,067,405(+) AATTT(A/C/G)TAAGG intron-variant
rs1000810369 -- 43,060,798(+) GTAAT(A/G)TGGAT intron-variant, upstream-variant-2KB
rs1001398014 -- 43,068,300(+) AACCC(C/T)GTCTC intron-variant
rs1001765872 -- 43,068,512(+) TTTGT(G/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLC4 Gene

Variant ID Type Subtype PubMed ID
nsv950169 CNV deletion 24416366
nsv602992 CNV loss 21841781
nsv462930 CNV loss 19166990
nsv462927 CNV loss 19166990
nsv437509 CNV loss 16327808
nsv1142639 CNV deletion 24896259
nsv1017398 CNV gain 25217958
esv3567716 CNV deletion 23714750
esv275497 CNV gain+loss 21479260
esv2731992 CNV deletion 23290073
esv2446917 CNV deletion 19546169
dgv10640n54 CNV loss 21841781

Variation tolerance for KLC4 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLC4 Gene

Human Gene Mutation Database (HGMD)
KLC4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLC4 Gene

Disorders for KLC4 Gene

Relevant External Links for KLC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLC4

No disorders were found for KLC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLC4 Gene

Publications for KLC4 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for KLC4 Gene

Sources for KLC4 Gene

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