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Aliases for KLC4 Gene

Aliases for KLC4 Gene

  • Kinesin Light Chain 4 2 3
  • Kinesin-Like Protein 8 3 4
  • KNSL8 3 4
  • Kinesin-Like 8 2
  • BA387M24.3 3
  • KLC 4 4

External Ids for KLC4 Gene

Previous HGNC Symbols for KLC4 Gene

  • KNSL8

Previous GeneCards Identifiers for KLC4 Gene

  • GC06P043136
  • GC06P043008
  • GC06P042744

Summaries for KLC4 Gene

GeneCards Summary for KLC4 Gene

KLC4 (Kinesin Light Chain 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is KLC2.

UniProtKB/Swiss-Prot for KLC4 Gene

  • Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Gene Wiki entry for KLC4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLC4 Gene

Genomics for KLC4 Gene

Regulatory Elements for KLC4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLC4 Gene

Start:
43,040,777 bp from pter
End:
43,075,099 bp from pter
Size:
34,323 bases
Orientation:
Plus strand

Genomic View for KLC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLC4 Gene

Proteins for KLC4 Gene

  • Protein details for KLC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSK0-KLC4_HUMAN
    Recommended name:
    Kinesin light chain 4
    Protein Accession:
    Q9NSK0
    Secondary Accessions:
    • B3KNY4
    • B3KPI3
    • B3KSQ3
    • B4DME9
    • Q66K28
    • Q96EG6

    Protein attributes for KLC4 Gene

    Size:
    619 amino acids
    Molecular mass:
    68640 Da
    Quaternary structure:
    • Oligomeric complex composed of two heavy chains and two light chains.
    SequenceCaution:
    • Sequence=BAC86788.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLC4 Gene

Proteomics data for KLC4 Gene at MOPED

Post-translational modifications for KLC4 Gene

  • Ubiquitination at Lys307
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KLC4 Gene

Domains for KLC4 Gene

Gene Families for KLC4 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Suggested Antigen Peptide Sequences for KLC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSK0

UniProtKB/Swiss-Prot:

KLC4_HUMAN :
  • Q9NSK0
Family:
  • Belongs to the kinesin light chain family.
Similarity:
  • Contains 7 TPR repeats.
genes like me logo Genes that share domains with KLC4: view

Function for KLC4 Gene

Molecular function for KLC4 Gene

UniProtKB/Swiss-Prot Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Gene Ontology (GO) - Molecular Function for KLC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLC4: view

Phenotypes for KLC4 Gene

GenomeRNAi human phenotypes for KLC4:
genes like me logo Genes that share phenotypes with KLC4: view

Animal Model Products

CRISPR Products

miRNA for KLC4 Gene

miRTarBase miRNAs that target KLC4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLC4 Gene

Localization for KLC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLC4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLC4 Gene COMPARTMENTS Subcellular localization image for KLC4 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KLC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005871 kinesin complex IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KLC4: view

Pathways for KLC4 Gene

genes like me logo Genes that share pathways with KLC4: view

Gene Ontology (GO) - Biological Process for KLC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KLC4: view

Transcripts for KLC4 Gene

Unigene Clusters for KLC4 Gene

Kinesin light chain 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLC4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KLC4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLC4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - - - -
SP13: - - - - -
SP14:

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KLC4 Gene

GeneLoc Exon Structure for
KLC4
ECgene alternative splicing isoforms for
KLC4

Expression for KLC4 Gene

mRNA expression in normal human tissues for KLC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLC4 Gene

This gene is overexpressed in Liver (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLC4 Gene

SOURCE GeneReport for Unigene cluster for KLC4 Gene Hs.655123

genes like me logo Genes that share expressions with KLC4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KLC4 Gene

Orthologs for KLC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLC4 35
  • 99.74 (n)
  • 100 (a)
KLC4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLC4 35
  • 89.02 (n)
  • 94.01 (a)
KLC4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLC4 35
  • 90.69 (n)
  • 95.94 (a)
KLC4 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klc4 35
  • 87.83 (n)
  • 94.35 (a)
Klc4 16
Klc4 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLC4 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KLC4 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klc4 35
  • 87.94 (n)
  • 95.8 (a)
chicken
(Gallus gallus)
Aves KLC4 35
  • 74.85 (n)
  • 79.63 (a)
KLC4 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLC4 36
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii klc1b 35
  • 71 (n)
  • 76.5 (a)
klc4 36
  • 69 (a)
OneToMany
klc4 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Klc 36
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klc-1 36
  • 42 (a)
ManyToMany
klc-2 36
  • 58 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for KLC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLC4 Gene

ENSEMBL:
Gene Tree for KLC4 (if available)
TreeFam:
Gene Tree for KLC4 (if available)

Paralogs for KLC4 Gene

Paralogs for KLC4 Gene

Selected SIMAP similar genes for KLC4 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with KLC4: view

Variants for KLC4 Gene

Sequence variations from dbSNP and Humsavar for KLC4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs869069 -- 43,070,325(-) TCAGA(C/T)ATTTG intron-variant
rs1214705 -- 43,065,136(+) ATGGC(A/G)TGATC intron-variant
rs2152048 -- 43,073,381(+) tgcag(G/T)ggctc intron-variant
rs4711739 -- 43,063,678(+) cctct(C/T)gagta intron-variant
rs4711740 -- 43,069,063(+) AGATC(A/G)CACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLC4 Gene

Variant ID Type Subtype PubMed ID
nsv462927 CNV Loss 19166990
nsv462930 CNV Loss 19166990
esv2446917 CNV Deletion 19546169
esv2731992 CNV Deletion 23290073
nsv437509 CNV Loss 16327808
esv275497 CNV Gain+Loss 21479260

Relevant External Links for KLC4 Gene

HapMap Linkage Disequilibrium report
KLC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLC4 Gene

Disorders for KLC4 Gene

No disorders were found for KLC4 Gene.

No data available for UniProtKB/Swiss-Prot for KLC4 Gene

Publications for KLC4 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for KLC4 Gene

Sources for KLC4 Gene

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