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Aliases for KLC4 Gene

Aliases for KLC4 Gene

  • Kinesin Light Chain 4 2 3 5
  • Kinesin-Like Protein 8 3 4
  • KNSL8 3 4
  • Kinesin-Like 8 2
  • BA387M24.3 3
  • KLC 4 4

External Ids for KLC4 Gene

Previous HGNC Symbols for KLC4 Gene

  • KNSL8

Previous GeneCards Identifiers for KLC4 Gene

  • GC06P043136
  • GC06P043008
  • GC06P042744

Summaries for KLC4 Gene

GeneCards Summary for KLC4 Gene

KLC4 (Kinesin Light Chain 4) is a Protein Coding gene. Among its related pathways are Innate Immune System and Golgi-to-ER retrograde transport. GO annotations related to this gene include microtubule motor activity. An important paralog of this gene is KLC2.

UniProtKB/Swiss-Prot for KLC4 Gene

  • Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Gene Wiki entry for KLC4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLC4 Gene

Genomics for KLC4 Gene

Regulatory Elements for KLC4 Gene

Enhancers for KLC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G043266 2 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +232.7 232676 13.1 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 SP3 CUL7 POLH RPS2P29 RRP36 KLC4 ENSG00000271754 DNPH1 UBR2 ENSG00000271970 CUL9
GH06G043119 1.6 Ensembl ENCODE dbSUPER 11.7 +82.6 82613 8.7 FOXA2 PKNOX1 MLX ZFP64 ARID4B DMAP1 FEZF1 FOS ZNF263 SP3 CUL7 BICRAL POLH ENSG00000271970 RPL24P4 RPL34P14 RPS2P29 UBR2 PEX6 PTK7
GH06G042901 1.5 Ensembl ENCODE dbSUPER 11.2 -137.7 -137727 3.3 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 TCF12 RPL7L1 PEX6 CNPY3 ENSG00000231113 PPP2R5D RN7SL403P KLC4 CUL7 KLHDC3 MEA1
GH06G043141 1.4 Ensembl ENCODE 11.4 +102.7 102686 3.6 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF2 ZNF302 ZNF143 KLF13 ZNF263 CUL7 ENSG00000271970 BICRAL POLH RPL24P4 RPL34P14 RPS2P29 DNPH1 PEX6 KLC4
GH06G042928 1.4 ENCODE dbSUPER 10.7 -110.0 -109989 5.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PEX6 POLH PPP2R5D RRP36 RPL24P4 BICRAL RPL34P14 KLHDC3 MEA1 KLC4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KLC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLC4 Gene

Chromosome:
6
Start:
43,040,777 bp from pter
End:
43,075,099 bp from pter
Size:
34,323 bases
Orientation:
Plus strand

Genomic View for KLC4 Gene

Genes around KLC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLC4 Gene

Proteins for KLC4 Gene

  • Protein details for KLC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSK0-KLC4_HUMAN
    Recommended name:
    Kinesin light chain 4
    Protein Accession:
    Q9NSK0
    Secondary Accessions:
    • B3KNY4
    • B3KPI3
    • B3KSQ3
    • B4DME9
    • Q66K28
    • Q96EG6

    Protein attributes for KLC4 Gene

    Size:
    619 amino acids
    Molecular mass:
    68640 Da
    Quaternary structure:
    • Oligomeric complex composed of two heavy chains and two light chains.
    SequenceCaution:
    • Sequence=BAC86788.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for KLC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLC4 Gene

Post-translational modifications for KLC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KLC4 Gene

Domains & Families for KLC4 Gene

Gene Families for KLC4 Gene

Suggested Antigen Peptide Sequences for KLC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSK0

UniProtKB/Swiss-Prot:

KLC4_HUMAN :
  • Belongs to the kinesin light chain family.
Family:
  • Belongs to the kinesin light chain family.
genes like me logo Genes that share domains with KLC4: view

Function for KLC4 Gene

Molecular function for KLC4 Gene

UniProtKB/Swiss-Prot Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Gene Ontology (GO) - Molecular Function for KLC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KLC4: view

Phenotypes for KLC4 Gene

genes like me logo Genes that share phenotypes with KLC4: view

Animal Model Products

CRISPR Products

miRNA for KLC4 Gene

miRTarBase miRNAs that target KLC4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLC4 Gene

Localization for KLC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLC4 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KLC4 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KLC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005871 kinesin complex IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KLC4: view

Pathways & Interactions for KLC4 Gene

genes like me logo Genes that share pathways with KLC4: view

Gene Ontology (GO) - Biological Process for KLC4 Gene

None

No data available for SIGNOR curated interactions for KLC4 Gene

Drugs & Compounds for KLC4 Gene

No Compound Related Data Available

Transcripts for KLC4 Gene

Unigene Clusters for KLC4 Gene

Kinesin light chain 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLC4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - - - -
SP13: - - - - -
SP14:

ExUns: 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KLC4 Gene

GeneLoc Exon Structure for
KLC4
ECgene alternative splicing isoforms for
KLC4

Expression for KLC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KLC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLC4 Gene

This gene is overexpressed in Liver (x4.2).

Protein differential expression in normal tissues from HIPED for KLC4 Gene

This gene is overexpressed in Heart (22.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KLC4 Gene



Protein tissue co-expression partners for KLC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KLC4 Gene:

KLC4

SOURCE GeneReport for Unigene cluster for KLC4 Gene:

Hs.655123

Evidence on tissue expression from TISSUES for KLC4 Gene

  • Nervous system(4.9)
  • Intestine(4.6)
  • Adrenal gland(4.4)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with KLC4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLC4 Gene

Orthologs for KLC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLC4 35 34
  • 99.74 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLC4 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLC4 34 35
  • 90.69 (n)
cow
(Bos Taurus)
Mammalia KLC4 34 35
  • 89.02 (n)
rat
(Rattus norvegicus)
Mammalia Klc4 34
  • 87.94 (n)
mouse
(Mus musculus)
Mammalia Klc4 34 16 35
  • 87.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KLC4 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves KLC4 35 34
  • 74.85 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KLC4 35
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii klc1b 34
  • 71 (n)
klc4 35 35
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Klc 35
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klc-2 35
  • 58 (a)
ManyToMany
klc-1 35
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 63 (a)
OneToMany
Species where no ortholog for KLC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLC4 Gene

ENSEMBL:
Gene Tree for KLC4 (if available)
TreeFam:
Gene Tree for KLC4 (if available)

Paralogs for KLC4 Gene

Paralogs for KLC4 Gene

genes like me logo Genes that share paralogs with KLC4: view

Variants for KLC4 Gene

Sequence variations from dbSNP and Humsavar for KLC4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000433413 -- 43,072,965(+) CCGGG(A/G)TAAGT splice-donor-variant
rs1000539582 -- 43,067,405(+) AATTT(A/C/G)TAAGG intron-variant
rs1000810369 -- 43,060,798(+) GTAAT(A/G)TGGAT intron-variant, upstream-variant-2KB
rs1001398014 -- 43,068,300(+) AACCC(C/T)GTCTC intron-variant
rs1001765872 -- 43,068,512(+) TTTGT(G/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLC4 Gene

Variant ID Type Subtype PubMed ID
dgv10640n54 CNV loss 21841781
esv2446917 CNV deletion 19546169
esv2731992 CNV deletion 23290073
esv275497 CNV gain+loss 21479260
esv3567716 CNV deletion 23714750
nsv1017398 CNV gain 25217958
nsv1142639 CNV deletion 24896259
nsv437509 CNV loss 16327808
nsv462927 CNV loss 19166990
nsv462930 CNV loss 19166990
nsv602992 CNV loss 21841781
nsv950169 CNV deletion 24416366

Variation tolerance for KLC4 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLC4 Gene

Human Gene Mutation Database (HGMD)
KLC4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KLC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLC4 Gene

Disorders for KLC4 Gene

Relevant External Links for KLC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLC4

No disorders were found for KLC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLC4 Gene

Publications for KLC4 Gene

  1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for KLC4 Gene

Sources for KLC4 Gene

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