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Aliases for KLC3 Gene

Aliases for KLC3 Gene

  • Kinesin Light Chain 3 2 3 5
  • Kinesin Light Chain 2 3 4
  • KLC2L 3 4
  • KLC2 3 4
  • KLC2-Like 4
  • KNS2B 3
  • KLCt 3

External Ids for KLC3 Gene

Previous GeneCards Identifiers for KLC3 Gene

  • GC19P050538
  • GC19P045847
  • GC19P042276
  • GC19P045851

Summaries for KLC3 Gene

Entrez Gene Summary for KLC3 Gene

  • This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLC3 Gene

KLC3 (Kinesin Light Chain 3) is a Protein Coding gene. Among its related pathways are Salmonella infection (KEGG) and Immune System. GO annotations related to this gene include microtubule binding and kinesin binding. An important paralog of this gene is KLC4.

UniProtKB/Swiss-Prot for KLC3 Gene

  • Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

Gene Wiki entry for KLC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLC3 Gene

Genomics for KLC3 Gene

Regulatory Elements for KLC3 Gene

Enhancers for KLC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KLC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLC3 Gene

Chromosome:
19
Start:
45,333,434 bp from pter
End:
45,351,559 bp from pter
Size:
18,126 bases
Orientation:
Plus strand

Genomic View for KLC3 Gene

Genes around KLC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLC3 Gene

Proteins for KLC3 Gene

  • Protein details for KLC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P597-KLC3_HUMAN
    Recommended name:
    Kinesin light chain 3
    Protein Accession:
    Q6P597
    Secondary Accessions:
    • A0AVM3
    • A2RUT6
    • Q6GMU2
    • Q8NAL1
    • Q8WWJ9

    Protein attributes for KLC3 Gene

    Size:
    504 amino acids
    Molecular mass:
    55364 Da
    Quaternary structure:
    • Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C and ODF1 (By similarity).

    Alternative splice isoforms for KLC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLC3 Gene

Proteomics data for KLC3 Gene at MOPED

Post-translational modifications for KLC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KLC3 Gene

No data available for DME Specific Peptides for KLC3 Gene

Domains & Families for KLC3 Gene

Gene Families for KLC3 Gene

Protein Domains for KLC3 Gene

Suggested Antigen Peptide Sequences for KLC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P597

UniProtKB/Swiss-Prot:

KLC3_HUMAN :
  • The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).
  • Belongs to the kinesin light chain family.
  • Contains 5 TPR repeats.
Domain:
  • The heptad repeat (HR) motif is sufficient for interaction with kinesin heavy (KHL) chains and ODF1. The TPR region is involved in mitochondrial binding (By similarity).
Family:
  • Belongs to the kinesin light chain family.
Similarity:
  • Contains 5 TPR repeats.
genes like me logo Genes that share domains with KLC3: view

Function for KLC3 Gene

Molecular function for KLC3 Gene

UniProtKB/Swiss-Prot Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.

Gene Ontology (GO) - Molecular Function for KLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with KLC3: view
genes like me logo Genes that share phenotypes with KLC3: view

Animal Model Products

miRNA for KLC3 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLC3 Gene

Localization for KLC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLC3 Gene

Cytoplasm, cytoskeleton. Note=Elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLC3 Gene COMPARTMENTS Subcellular localization image for KLC3 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for KLC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031514 motile cilium IEA --
GO:0035253 ciliary rootlet IEA --
genes like me logo Genes that share ontologies with KLC3: view

Pathways & Interactions for KLC3 Gene

genes like me logo Genes that share pathways with KLC3: view

Gene Ontology (GO) - Biological Process for KLC3 Gene

None

No data available for SIGNOR curated interactions for KLC3 Gene

Drugs & Compounds for KLC3 Gene

(6) Drugs for KLC3 Gene - From: PharmGKB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2569
Oxaliplatin Approved, Investigational Pharma Antitumor agent, Platinum 1338
GSK-923295 Investigational Pharma CENP-E inhibitor,small-molecule, Kinesin protein inhibitors 0
platinum Pharma 0
Platinum compounds Pharma 0

(2) ApexBio Compounds for KLC3 Gene

Compound Action Cas Number
GSK-923295 CENP-E inhibitor,small-molecule 1088965-37-0
MPI-0479605 Mps1 inhibitor,selective and ATP competitive 1246529-32-7
genes like me logo Genes that share compounds with KLC3: view

Transcripts for KLC3 Gene

Unigene Clusters for KLC3 Gene

Kinesin light chain 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLC3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for KLC3 Gene

GeneLoc Exon Structure for
KLC3
ECgene alternative splicing isoforms for
KLC3

Expression for KLC3 Gene

mRNA expression in normal human tissues for KLC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KLC3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x16.7), Skin - Sun Exposed (Lower leg) (x15.9), and Esophagus - Mucosa (x4.8).

Protein differential expression in normal tissues from HIPED for KLC3 Gene

This gene is overexpressed in Cervix (30.3), Peripheral blood mononuclear cells (8.9), and Monocytes (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLC3 Gene



SOURCE GeneReport for Unigene cluster for KLC3 Gene Hs.298079

genes like me logo Genes that share expression patterns with KLC3: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KLC3 Gene

Orthologs for KLC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLC3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLC3 35
  • 89.07 (n)
  • 91.85 (a)
KLC3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLC3 35
  • 88.8 (n)
  • 91.85 (a)
KLC3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klc3 35
  • 85.69 (n)
  • 91.05 (a)
Klc3 16
Klc3 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KLC3 35
  • 99.34 (n)
  • 99.6 (a)
KLC3 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Klc3 35
  • 83.9 (n)
  • 88.07 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 3 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia KLC3 36
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii klc3 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Klc 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klc-1 36
  • 34 (a)
ManyToMany
klc-2 36
  • 43 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for KLC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLC3 Gene

ENSEMBL:
Gene Tree for KLC3 (if available)
TreeFam:
Gene Tree for KLC3 (if available)

Paralogs for KLC3 Gene

Paralogs for KLC3 Gene

(6) SIMAP similar genes for KLC3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KLC3: view

Variants for KLC3 Gene

Sequence variations from dbSNP and Humsavar for KLC3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12977048 -- 45,344,298(+) AACCT(C/T)CGCCT intron-variant, upstream-variant-2KB
rs12977807 -- 45,345,877(+) CAGGT(A/T)TGTAG intron-variant
rs12978429 -- 45,345,837(+) GGTCA(G/T)CTGAG intron-variant
rs12979984 -- 45,346,432(+) CTGGG(C/G)GTGTC intron-variant
rs12981960 -- 45,349,701(+) TGGGG(G/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLC3 Gene

Variant ID Type Subtype PubMed ID
nsv833844 CNV Loss 17160897
nsv912146 CNV Loss 21882294
nsv833845 CNV Loss 17160897
nsv470146 CNV Loss 18288195
nsv458711 CNV Gain 19166990
dgv29n64 CNV Gain 17921354
nsv442466 CNV CNV 18776908

Variation tolerance for KLC3 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLC3 Gene

HapMap Linkage Disequilibrium report
KLC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLC3 Gene

Disorders for KLC3 Gene

Relevant External Links for KLC3

Genetic Association Database (GAD)
KLC3
Human Genome Epidemiology (HuGE) Navigator
KLC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLC3

No disorders were found for KLC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KLC3 Gene

Publications for KLC3 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins. (PMID: 25209998) Atherton J. … Moores C.A. (Elife 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KLC3 Gene

Sources for KLC3 Gene

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