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KLC2 Gene

protein-coding   GIFtS: 61
GCID: GC11P066026

Kinesin Light Chain 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kinesin Light Chain 21 2
KLC 22 3

External Ids:    HGNC: 207161   Entrez Gene: 648372   Ensembl: ENSG000001749967   OMIM: 6117295   UniProtKB: Q9H0B63   

Export aliases for KLC2 gene to outside databases

Previous GC identifers: GC19U990148 GC11P067706 GC11P066275 GC11P065800 GC11P065781 GC11P062350


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KLC2 Gene:
Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules.
Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1
stoichiometric ratio (Rahman et al., 1998 (PubMed 9624122)).(supplied by OMIM, Mar 2008)

GeneCards Summary for KLC2 Gene:
KLC2 (kinesin light chain 2) is a protein-coding gene. GO annotations related to this gene include microtubule motor activity and kinesin binding. An important paralog of this gene is ENSG00000256500.

UniProtKB/Swiss-Prot: KLC2_HUMAN, Q9H0B6
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity
(By similarity)

Gene Wiki entry for KLC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KLC2 gene promoter:
         E2F-1   E2F   E2F-2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLC2 promoter sequence
   Search Chromatin IP Primers for KLC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KLC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

KLC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLC2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066026:  view genomic region     (about GC identifiers)

Start:
66,024,765 bp from pter      End:
66,035,332 bp from pter
Size:
10,568 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KLC2_HUMAN, Q9H0B6 (See protein sequence)
Recommended Name: Kinesin light chain 2  
Size: 622 amino acids; 68935 Da
Subunit: Oligomeric complex composed of two heavy chains and two light chains (By similarity)
2 PDB 3D structures from and Proteopedia for KLC2:
3CEQ (3D)        3EDT (3D)    
Secondary accessions: A8MXL7 B2RDY4 Q9H9C8 Q9HA20
Alternative splicing: 2 isoforms:  Q9H0B6-1   Q9H0B6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLC2: NX_Q9H0B6

Explore proteomics data for KLC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys294
  • Modification sites at PhosphoSitePlus

  • See KLC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128246.1  NP_001128247.1  NP_001128248.1  NP_073733.1  

    ENSEMBL proteins: 
     ENSP00000436577   ENSP00000437026   ENSP00000396952   ENSP00000377631   ENSP00000314837  
     ENSP00000377641   ENSP00000434538   ENSP00000431253   ENSP00000377630   ENSP00000377629  
     ENSP00000399403   ENSP00000408484  
    Reactome Protein details: Q9H0B6

    KLC2 Human Recombinant Protein Products:

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    Novus Biologicals KLC2 Protein
    Novus Biologicals KLC2 Lysates
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    Cloud-Clone Corp. Proteins for KLC2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR015792 Kinesin_light_repeat
     IPR002151 Kinesin_light
     IPR015390 Rabaptin_Rab5-bd_dom
     IPR013105 TPR_2

    Graphical View of Domain Structure for InterPro Entry Q9H0B6

    ProtoNet protein and cluster: Q9H0B6

    1 Blocks protein domain: IPB002151 Kinesin light chain

    UniProtKB/Swiss-Prot: KLC2_HUMAN, Q9H0B6
    Similarity: Belongs to the kinesin light chain family
    Similarity: Contains 6 TPR repeats


    Find genes that share domains with KLC2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLC2_HUMAN, Q9H0B6
    Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
    The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity
    (By similarity)

         Genatlas biochemistry entry for KLC2:
    kinesin,light chain,beta 2,with homology to purple sea urchin SPKLC,widely expressed

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI14985359
    GO:0019894kinesin binding ISS--
         
    Find genes that share ontologies with KLC2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KLC2:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KLC2
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    miRNA
    Products:
        
    miRTarBase miRNAs that target KLC2:
    hsa-mir-92a-3p (MIRT049334), hsa-mir-30c-5p (MIRT047944), hsa-mir-331-3p (MIRT043375), hsa-mir-484 (MIRT042175)

    Block miRNA regulation of human, mouse, rat KLC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KLC2 (see all 36):
    hsa-miR-15a hsa-miR-139-5p hsa-miR-486-3p hsa-miR-449a hsa-miR-409-5p hsa-miR-424 hsa-miR-761 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidKLC2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat KLC2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 4): KLC2 (NM_001134776)
    Sino Biological Human cDNA Clone for KLC2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KLC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLC2
    Addgene plasmids for KLC2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KLC2_HUMAN, Q9H0B6: Cytoplasm, cytoskeleton (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005871kinesin complex ISS--
    GO:0005874microtubule IEA--
    GO:0016938kinesin I complex NAS--

    Find genes that share ontologies with KLC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KLC2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    4Salmonella infection (KEGG)
    Salmonella infection0.30
    5MHC class II antigen presentation
    MHC class II antigen presentation


    Find genes that share SuperPaths with KLC2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for KLC2
        MHC class II antigen presentation
    Kinesins


    1 Kegg Pathway  (Kegg details for KLC2):
        Salmonella infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KLC2
    Interactions:

        Search GeneGlobe Interaction Network for KLC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KLC2 (Q9H0B62, 3 ENSP000003148374) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384322, 3, ENSP000002403164MINT-2876052 I2D: score=3 STRING: ENSP00000240316
    S100A8P051092, 3MINT-63398 I2D: score=4 
    AIMP2Q131552, 3MINT-8258951 I2D: score=2 
    PIK3R3Q925692, 3MINT-8266260 I2D: score=2 
    SFNP319472, 3MINT-3975908 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement TAS--
    GO:0007596blood coagulation TAS--
    GO:0008088axon cargo transport IEA--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with KLC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KLC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KLC2 gene (4 alternative transcripts): 
    NM_001134774.1  NM_001134775.1  NM_001134776.1  NM_022822.2  

    Unigene Cluster for KLC2:

    Kinesin light chain 2
    Hs.280792  [show with all ESTs]
    Unigene Representative Sequence: AK126489
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531240 ENST00000526758 ENST00000440228 ENST00000394067 ENST00000316924(uc010row.1 uc001ohb.2 uc010rox.1 uc001ohc.2 uc001ohd.2)
    ENST00000394078 ENST00000461611 ENST00000475757 ENST00000394066 ENST00000394065(uc001ohe.1)
    ENST00000483152 ENST00000534023 ENST00000417856(uc010rov.1) ENST00000421552

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate KLC2 (see all 36):
    hsa-miR-15a hsa-miR-139-5p hsa-miR-486-3p hsa-miR-449a hsa-miR-409-5p hsa-miR-424 hsa-miR-761 hsa-miR-15b
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KLC2
    Addgene plasmids for KLC2 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KLC2
      QuantiTect SYBR Green Assays in human, mouse, rat KLC2
      QuantiFast Probe-based Assays in human, mouse, rat KLC2

    Additional mRNA sequence: 

    AK022449.1 AK022907.1 AK094593.1 AK126489.1 AK315725.1 AL136864.1 BC034373.1 BC128203.1 

    14 DOTS entries:

    DT.300696  DT.100779576  DT.95293736  DT.100699970  DT.100031611  DT.100679944  DT.99965383  DT.102823601 
    DT.120738316  DT.120738323  DT.95293725  DT.100732117  DT.91891031  DT.95185892 

    Selected AceView cDNA sequences (see all 705):

    BM476064 BM423911 BX464225 BE514115 BI522605 AA434103 BQ722819 BI906801 
    BP372300 BI837011 U66621 BE263864 W95610 BQ008186 CR605155 AI350693 
    BQ932462 AK094593 BQ878543 AW248294 CR604733 CR625419 BE730933 CA398202 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KLC2 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                                                                                                                                                            
    SP2:                                -     -           -                                                                                                         
    SP3:                    -     -     -                 -                                                                                                         
    SP4:                                -     -           -     -     -     -                                                                                       
    SP5:                    -     -     -     -           -                                                                                                         

    ExUns: 16a · 16b ^ 17 ^ 18
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for KLC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KLC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTGCTGC
    KLC2 Expression
    About this image


    KLC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    KLC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KLC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.280792
        Custom PCR Arrays for KLC2
    Primer
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    OriGene qPCR primer pairs and template standards for KLC2
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    QuantiFast Probe-based Assays in human, mouse, rat KLC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KLC2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klc21 , 5 kinesin light chain 21, 5 88.05(n)1
    95.96(a)1
      19 (4.25 cM)5
    165941  NM_008451.21  NP_032477.21 
     51077465 
    lizard
    (Anolis carolinensis)
    Reptilia KLC26
    kinesin light chain 2
    79(a)
    1 ↔ 1
    GL343519.1(108822-134647)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043636.12   -- 76.91(n)    BC043636.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556662 similar to kinesin 2 60/70kDa 77.5(n)   393913  BC045419.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klc6
    Kinesin light chain
    67(a)
    1 → many
    3L(12739716-12743156)
    worm
    (Caenorhabditis elegans)
    Secernentea klc-26
    klc-16
    Protein KLC-1, isoform b
    58(a)
    41(a)
    many ↔ many
    many ↔ many
    V(5575410-5581713) WBGene00002215
    IV(11083735-11086053) WBGene00002214


    ENSEMBL Gene Tree for KLC2 (if available)
    TreeFam Gene Tree for KLC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KLC2 gene
    ENSG000002565002  KLC42  KLC32  NPHP3-ACAD112  KLC12  
    5 SIMAP similar genes for KLC2 using alignment to 9 protein entries:     KLC2_HUMAN (see all proteins):
    KNS2    KLC1    KLC3    KLC4    NPHP3

    Find genes that share paralogs with KLC2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KLC2 (see all 278)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413884171,2
    --66022783(+) AGCCTC/TCTGAG 1 -- us2k10--------
    rs1451659381,2
    --66023015(+) ATCACA/CGATCC 1 -- us2k10--------
    rs1387927481,2
    --66023062(+) GAAAAC/TTGACC 1 -- us2k10--------
    rs1917696701,2
    --66023069(+) GACCAA/GCTGAA 1 -- us2k10--------
    rs1835090571,2
    --66023142(+) ACAACA/GGAAGT 2 -- us2k10--------
    rs789074411,2
    F--66023161(+) GAGAGG/CGGGGC 2 -- us2k12Minor allele frequency- C:0.03NA 122
    rs675602911,2
    C--66023242(+) TTTTT-/TTTTTT 4 -- us2k10--------
    rs1882892941,2
    --66023394(+) ACCACA/GCACAG 4 -- us2k10--------
    rs1818158321,2
    --66023427(+) AGACAA/GGGTTT 4 -- us2k10--------
    rs1405571201,2
    --66023523(+) TGAGCC/TACTGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLC2 (66024765 - 66035332 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897772CNV Loss21882294
    dgv1187n71CNV Loss21882294
    esv1000442OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KLC2
    DNA2.0 Custom Variant and Variant Library Synthesis for KLC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611729    OMIM disorders: --


    Find genes that share disorders with KLC2           About GenesLikeMe


    Export disorders for KLC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KLC2 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with KLC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. (PubMed id 9624122)1, 3 Rahman A....Goldstein L.S. (J. Biol. Chem. 1998)
    7. Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. (PubMed id 19773350)1, 9 Trejo H.E....Sznajder J.I. (FASEB J. 2010)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64837 HGNC: 20716 AceView: KLC2andRAB1B Ensembl:ENSG00000174996 euGenes: HUgn64837
    ECgene: KLC2 Kegg: 64837 H-InvDB: KLC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KLC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KLC2 gene:
    Search GeneIP for patents involving KLC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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