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Aliases for KLC2 Gene

Aliases for KLC2 Gene

  • Kinesin Light Chain 2 2 3
  • KLC 2 4

External Ids for KLC2 Gene

Summaries for KLC2 Gene

Entrez Gene Summary for KLC2 Gene

  • Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1 stoichiometric ratio (Rahman et al., 1998 [PubMed 9624122]).[supplied by OMIM, Mar 2008]

GeneCards Summary for KLC2 Gene

KLC2 (Kinesin Light Chain 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include microtubule motor activity and kinesin binding. An important paralog of this gene is KLC4.

UniProtKB/Swiss-Prot for KLC2 Gene

  • Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Gene Wiki entry for KLC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLC2 Gene

Genomics for KLC2 Gene

Genomic Location for KLC2 Gene

Start:
66,257,294 bp from pter
End:
66,267,861 bp from pter
Size:
10,568 bases
Orientation:
Plus strand

Genomic View for KLC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLC2 Gene

Regulatory Elements for KLC2 Gene

Proteins for KLC2 Gene

  • Protein details for KLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0B6-KLC2_HUMAN
    Recommended name:
    Kinesin light chain 2
    Protein Accession:
    Q9H0B6
    Secondary Accessions:
    • A8MXL7
    • B2RDY4
    • Q9H9C8
    • Q9HA20

    Protein attributes for KLC2 Gene

    Size:
    622 amino acids
    Molecular mass:
    68935 Da
    Quaternary structure:
    • Oligomeric complex composed of two heavy chains and two light chains.

    Three dimensional structures from OCA and Proteopedia for KLC2 Gene

    Alternative splice isoforms for KLC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KLC2 Gene

Proteomics data for KLC2 Gene at MOPED

Post-translational modifications for KLC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys294

No data available for DME Specific Peptides for KLC2 Gene

Domains for KLC2 Gene

Gene Families for KLC2 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

UniProtKB/Swiss-Prot:

KLC2_HUMAN
Family:
  • Belongs to the kinesin light chain family.:
    • Q9H0B6
Similarity:
  • Contains 6 TPR repeats.:
    • Q9H0B6
genes like me logo Genes that share domains with KLC2: view

Function for KLC2 Gene

Molecular function for KLC2 Gene

GENATLAS Biochemistry: kinesin,light chain,beta 2,with homology to purple sea urchin SPKLC,widely expressed
UniProtKB/Swiss-Prot Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).

Gene Ontology (GO) - Molecular Function for KLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 14985359
GO:0019894 kinesin binding ISS --
genes like me logo Genes that share ontologies with KLC2: view

Phenotypes for KLC2 Gene

GenomeRNAi human phenotypes for KLC2:
genes like me logo Genes that share phenotypes with KLC2: view

miRNA for KLC2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLC2 Gene

Localization for KLC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLC2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLC2 Gene COMPARTMENTS Subcellular localization image for KLC2 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005871 kinesin complex ISS --
GO:0005874 microtubule IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with KLC2: view

Pathways for KLC2 Gene

genes like me logo Genes that share pathways with KLC2: view

Gene Ontology (GO) - Biological Process for KLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007596 blood coagulation TAS --
GO:0008088 axon cargo transport IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KLC2: view

Transcripts for KLC2 Gene

Unigene Clusters for KLC2 Gene

Kinesin light chain 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KLC2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1:
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8: - - - - - -
SP9: - - - -
SP10: -

ExUns: 16a · 16b ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for KLC2 Gene

GeneLoc Exon Structure for
KLC2
ECgene alternative splicing isoforms for
KLC2

Expression for KLC2 Gene

mRNA expression in normal human tissues for KLC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLC2 Gene

SOURCE GeneReport for Unigene cluster for KLC2 Gene Hs.280792

genes like me logo Genes that share expressions with KLC2: view

Orthologs for KLC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLC2 36
  • 99.41 (n)
  • 99.68 (a)
KLC2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KLC2 36
  • 90.41 (n)
  • 94.21 (a)
KLC2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KLC2 36
  • 89.07 (n)
  • 95.34 (a)
KLC2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Klc2 36
  • 88.05 (n)
  • 95.96 (a)
Klc2 16
Klc2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KLC2 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Klc2 36
  • 87.83 (n)
  • 96.3 (a)
lizard
(Anolis carolinensis)
Reptilia KLC2 37
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13210 36
zebrafish
(Danio rerio)
Actinopterygii klc2 36
  • 73.61 (n)
  • 81.31 (a)
klc2 37
  • 80 (a)
OneToOne
zgc55666 36
fruit fly
(Drosophila melanogaster)
Insecta Klc 37
  • 67 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klc-1 37
  • 41 (a)
ManyToMany
klc-2 37
  • 58 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 62 (a)
OneToMany
Species with no ortholog for KLC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KLC2 Gene

ENSEMBL:
Gene Tree for KLC2 (if available)
TreeFam:
Gene Tree for KLC2 (if available)

Paralogs for KLC2 Gene

Paralogs for KLC2 Gene

Selected SIMAP similar genes for KLC2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with KLC2: view

Variants for KLC2 Gene

Sequence variations from dbSNP and Humsavar for KLC2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs474005 -- 66,265,830(+) ACTGC(C/T)TGATG intron-variant
rs510761 -- 66,260,882(+) gagcc(A/C)ccgtg intron-variant
rs521109 -- 66,263,477(+) CAATT(A/G)TGAGA intron-variant
rs525698 -- 66,263,979(+) CAGGC(C/T)GGGGG intron-variant
rs527959 -- 66,264,826(+) TTGGG(A/C)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLC2 Gene

Variant ID Type Subtype PubMed ID
esv1000442 OTHER Inversion 20482838
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294

Relevant External Links for KLC2 Gene

HapMap Linkage Disequilibrium report
KLC2

Disorders for KLC2 Gene

No disorders were found for KLC2 Gene.

No data available for UniProtKB/Swiss-Prot for KLC2 Gene

Publications for KLC2 Gene

  1. Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. (PMID: 19773350) Trejo H.E. … Sznajder J.I. (FASEB J. 2010) 3 23
  2. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. (PMID: 9624122) Rahman A. … Goldstein L.S. (J. Biol. Chem. 1998) 2 3
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KLC2 Gene

  • Addgene plasmids for KLC2

Sources for KLC2 Gene

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