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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KLC2 Gene

protein-coding   GIFtS: 60
GCID: GC11P066026

Kinesin Light Chain 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinesin Light Chain 21 2
KLC 22 3

External Ids:    HGNC: 207161   Entrez Gene: 648372   Ensembl: ENSG000001749967   OMIM: 6117295   UniProtKB: Q9H0B63   

Export aliases for KLC2 gene to outside databases

Previous GC identifers: GC19U990148 GC11P067706 GC11P066275 GC11P065800 GC11P065781 GC11P062350


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLC2 Gene:
Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules.
Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1
stoichiometric ratio (Rahman et al., 1998 (PubMed 9624122)).(supplied by OMIM, Mar 2008)

GeneCards Summary for KLC2 Gene: 
KLC2 (kinesin light chain 2) is a protein-coding gene. Diseases associated with KLC2 include vaccinia, and neuronitis, and among its related super-pathways are Immune System and Kinesins. GO annotations related to this gene include microtubule motor activity and kinesin binding. An important paralog of this gene is ENSG00000256500.

UniProtKB/Swiss-Prot: KLC2_HUMAN, Q9H0B6
Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity
(By similarity)

Gene Wiki entry for KLC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KLC2 gene promoter:
         E2F-1   E2F   E2F-2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKLC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KLC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1

KLC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLC2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066026:  view genomic region     (about GC identifiers)

Start:
66,024,765 bp from pter      End:
66,035,332 bp from pter
Size:
10,568 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KLC2_HUMAN, Q9H0B6 (See protein sequence)
Recommended Name: Kinesin light chain 2  
Size: 622 amino acids; 68935 Da
Subunit: Oligomeric complex composed of two heavy chains and two light chains (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (Probable)
2 PDB 3D structures from and Proteopedia for KLC2:
3CEQ (3D)        3EDT (3D)    
Secondary accessions: A8MXL7 B2RDY4 Q9H9C8 Q9HA20
Alternative splicing: 2 isoforms:  Q9H0B6-1   Q9H0B6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KLC2: NX_Q9H0B6

Explore proteomics data for KLC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0B6

  • KLC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KLC2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001128246.1  NP_001128247.1  NP_001128248.1  NP_073733.1  

    ENSEMBL proteins: 
     ENSP00000436577   ENSP00000437026   ENSP00000396952   ENSP00000377631   ENSP00000314837  
     ENSP00000377641   ENSP00000434538   ENSP00000431253   ENSP00000377630   ENSP00000377629  
     ENSP00000399403   ENSP00000408484  
    Reactome Protein details: Q9H0B6
    Human Recombinant Protein Products for KLC2: 
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    Novus Biologicals KLC2 Protein
    Novus Biologicals KLC2 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KLC2 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005871kinesin complex ISS--
    GO:0005874microtubule IEA--
    GO:0016938kinesin I complex NAS--

    KLC2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5/7 InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR015792 Kinesin_light_repeat
     IPR002151 Kinesin_light
     IPR015390 Rabaptin_Rab5-bd_dom
     IPR013105 TPR_2

    Graphical View of Domain Structure for InterPro Entry Q9H0B6

    ProtoNet protein and cluster: Q9H0B6

    1 Blocks protein domain: IPB002151 Kinesin light chain

    UniProtKB/Swiss-Prot: KLC2_HUMAN, Q9H0B6
    Similarity: Belongs to the kinesin light chain family
    Similarity: Contains 6 TPR repeats


    KLC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KLC2_HUMAN, Q9H0B6
    Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.
    The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity
    (By similarity)

         Genatlas biochemistry entry for KLC2:
    kinesin,light chain,beta 2,with homology to purple sea urchin SPKLC,widely expressed

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003777microtubule motor activity IEA--
    GO:0005515protein binding IPI14985359
    GO:0019894kinesin binding ISS--
         
    KLC2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KLC2:
     Proliferating cells 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidKLC2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KLC2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2MHC class II antigen presentation
    MHC class II antigen presentation0.32
    Kinesins0.32
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    4Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules0.32
    5Salmonella infection
    Salmonella infection

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for KLC2
        Cytoplasmic microtubules



    5/6        Reactome Pathways for KLC2 (see all 6)
        Hemostasis
    Factors involved in megakaryocyte development and platelet production
    Adaptive Immune System
    Immune System
    Kinesins


    1         Kegg Pathway  (Kegg details for KLC2):
        Salmonella infection


    KLC2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KLC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for KLC2 (Q9H0B62, 3 ENSP000003148374) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384322, 3, ENSP000002403164MINT-2876052 I2D: score=3 STRING: ENSP00000240316
    S100A8P051092, 3MINT-63398 I2D: score=4 
    AIMP2Q131552, 3MINT-8258951 I2D: score=2 
    PIK3R3Q925692, 3MINT-8266260 I2D: score=2 
    SFNP319472, 3MINT-3975908 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement TAS--
    GO:0007596blood coagulation TAS--
    GO:0008088axon cargo transport IEA--
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    KLC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KLC2

    Search CenterWatch for drugs/clinical trials and news about KLC2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KLC2 gene (4 alternative transcripts): 
    NM_001134774.1  NM_001134775.1  NM_001134776.1  NM_022822.2  

    Unigene Cluster for KLC2:

    Kinesin light chain 2
    Hs.280792  [show with all ESTs]
    Unigene Representative Sequence: AK126489
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531240 ENST00000526758 ENST00000440228 ENST00000394067 ENST00000316924(uc010row.1 uc001ohb.2 uc010rox.1 uc001ohc.2 uc001ohd.2)
    ENST00000394078 ENST00000461611 ENST00000475757 ENST00000394066 ENST00000394065(uc001ohe.1)
    ENST00000483152 ENST00000534023 ENST00000417856(uc010rov.1) ENST00000421552

    miRNA
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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate KLC2 (see all 36):
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    Additional mRNA sequence: 

    AK022449.1 AK022907.1 AK094593.1 AK126489.1 AK315725.1 AL136864.1 BC034373.1 BC128203.1 

    14 DOTS entries:

    DT.300696  DT.100779576  DT.95293736  DT.100699970  DT.100031611  DT.100679944  DT.99965383  DT.102823601 
    DT.120738316  DT.120738323  DT.95293725  DT.100732117  DT.91891031  DT.95185892 

    24/705 AceView cDNA sequences (see all 705):

    BQ686658 BC034373 AW733009 BQ881775 BM811154 AL558136 BI763877 BM750031 
    BE263864 BX107600 BU630601 BI861010 BM851993 BE170824 CR598883 CR605155 
    BI764071 AA434103 CA398202 BM789623 AK094593 BE514115 CA489174 AI284573 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KLC2 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
    SP1:                                                                                                                                                            
    SP2:                                -     -           -                                                                                                         
    SP3:                    -     -     -                 -                                                                                                         
    SP4:                                -     -           -     -     -     -                                                                                       
    SP5:                    -     -     -     -           -                                                                                                         

    ExUns: 16a · 16b ^ 17 ^ 18
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for KLC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KLC2 expression in normal human tissues (normalized intensities)      KLC2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTGCTGC
    KLC2 Expression
    About this image


    KLC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             cerebellum   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See KLC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KLC2

    SOURCE GeneReport for Unigene cluster: Hs.280792
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KLC2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Klc21 , 5 kinesin light chain 21, 5 88.05(n)1
    95.96(a)1
      19 (4.25 cM)5
    165941  NM_008451.21  NP_032477.21 
     51077465 
    chicken
    (Gallus gallus)
    Aves KLC26
    kinesin light chain 2
    69(a)
    1 ↔ 1
    3(4299439-4314233)
    lizard
    (Anolis carolinensis)
    Reptilia KLC26
    --
    --
    79(a)
    72(a)
    1 ↔ 1
    possible ortholog
    GL343519.1(108822-134647)
    2(144116959-144163051)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043636.12   -- 76.91(n)    BC043636.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc556662 similar to kinesin 2 60/70kDa 77.5(n)   393913  BC045419.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Klc6
    Kinesin light chain
    66(a)
    1 → many
    3L(12739716-12743156)
    worm
    (Caenorhabditis elegans)
    Secernentea klc-26
    klc-16
    Protein KLC-1, isoform b
    57(a)
    41(a)
    many ↔ many
    many ↔ many
    V(5575410-5581713)
    IV(11083735-11086053)


    ENSEMBL Gene Tree for KLC2 (if available)
    TreeFam Gene Tree for KLC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KLC2 gene
    ENSG000002565002  KLC42  KLC32  KLC12  NPHP32  
    5 SIMAP similar genes for KLC2 using alignment to 9 protein entries:     KLC2_HUMAN (see all proteins):
    KNS2    KLC1    KLC3    KLC4    NPHP3

    KLC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/278 SNPs in KLC2 are shown (see all 278)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413884171,2
    --66022783(+) AGCCTC/TCTGAG 1 -- us2k10--------
    rs1451659381,2
    --66023015(+) ATCACA/CGATCC 1 -- us2k10--------
    rs1387927481,2
    --66023062(+) GAAAAC/TTGACC 1 -- us2k10--------
    rs1917696701,2
    --66023069(+) GACCAA/GCTGAA 1 -- us2k10--------
    rs1835090571,2
    --66023142(+) ACAACA/GGAAGT 2 -- us2k10--------
    rs789074411,2
    F--66023161(+) GAGAGG/CGGGGC 2 -- us2k12Minor allele frequency- C:0.03NA 122
    rs675602911,2
    C--66023242(+) TTTTT-/TTTTTT 4 -- us2k10--------
    rs1882892941,2
    --66023394(+) ACCACA/GCACAG 4 -- us2k10--------
    rs1818158321,2
    --66023427(+) AGACAA/GGGTTT 4 -- us2k10--------
    rs1405571201,2
    --66023523(+) TGAGCC/TACTGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for KLC2 (66024765 - 66035332 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KLC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897772CNV Loss21882294
    dgv1187n71CNV Loss21882294
    esv1000442OTHER Inversion20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611729    OMIM disorders: --

    2 diseases for KLC2:    About MalaCards
    vaccinia    neuronitis


    KLC2 for disorders           About GeneDecksing


    Export disorders for KLC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KLC2 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with KLC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. (PubMed id 9624122)1, 3 Rahman A....Goldstein L.S. (1998)
    7. Role of kinesin light chain-2 of kinesin-1 in the tra ffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells. (PubMed id 19773350)1, 9 Trejo H.E....Sznajder J.I. (2010)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64837 HGNC: 20716 AceView: KLC2andRAB1B Ensembl:ENSG00000174996 euGenes: HUgn64837
    ECgene: KLC2 Kegg: 64837 H-InvDB: KLC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KLC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KLC2 gene:
    Search GeneIP for patents involving KLC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     Regulatory tfbs in KLC2 promoter
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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