Aliases for KLC1 Gene
External Ids for KLC1 Gene
Previous HGNC Symbols for KLC1 Gene
Previous GeneCards Identifiers for KLC1 Gene
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for KLC1 Gene
KLC1 (Kinesin Light Chain 1) is a Protein Coding gene. Diseases associated with KLC1 include Medulloblastoma. Among its related pathways are Golgi-to-ER retrograde transport and Signaling by Rho GTPases. GO annotations related to this gene include microtubule motor activity and tubulin binding. An important paralog of this gene is KLC4.
UniProtKB/Swiss-Prot for KLC1 Gene
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.