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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KLC1 Gene

protein-coding GIFtS: 60
GCID: GC14P104028

kinesin light chain 1

(Previous names: kinesin 2 60/70kDa, kinesin 2 )
(Previous symbol: KNS2)

Explore 10 diseases affiliated with
KLC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Kinesin Light Chain 1¹ ²		HKLC1J¹
KNS2¹ ² ³ ⁵		HKLC1N¹
KLC¹ ² ³		HKLC1P¹
KNS2A¹ ² ⁵		HKLC1R¹
Kinesin 2 60/70kDa¹ ²		HKLC1S¹
KLC 1² ³		Kinesin 2¹
HKLC1B¹		Medulloblastoma Antigen MU-MB-2.50²
HKLC1G¹

External Ids:	HGNC: 6387¹	Entrez Gene: 3831²	Ensembl: ENSG00000126214⁷	OMIM: 600025⁵	UniProtKB: Q07866³

Export aliases for KLC1 gene to outside databases

Previous GC identifers: GC14P103167 GC14P104030 GC14P104095

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KLC1:

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various

cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains

bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy

chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in

binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as

adapter molecules and not motors per se. Although previously named 'kinesin 2', this gene is not a member of the

kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms

with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or

biological validity of most of these variants have not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: KLC1_HUMAN, Q07866

Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The

light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity

Gene Wiki entry for KLC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KLC1 gene promoter:
AP-1 Bach2 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) AP-4 POU3F2 NF-E2 p45 c-Myb NF-E2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KLC1 promoter sequence

Search SABiosciences Chromatin IP Primers for KLC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KLC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.3 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.3

KLC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KLC1 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P104028: view genomic region (about GC identifiers)

Start:	104,028,233 bp from pter	End:	104,167,888 bp from pter
Size:	139,656 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KLC1_HUMAN, Q07866 (See protein sequence)

Recommended Name: Kinesin light chain 1

Size: 573 amino acids; 65310 Da

Subunit: Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9 (By similarity).

Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections (By

similarity). Interacts with adenovirus hexon-interlacing protein; this interaction leads to capsid disruption at the

nuclear pore complex during virus entry into host cell

Subcellular location: Cytoplasm, cytoskeleton (Probable)

Caution: It is uncertain whether Met-1 or Met-5 is the initiator

Sequence caution: Sequence=AAA16576.1; Type=Erroneous initiation; Sequence=AAF72543.1; Type=Erroneous initiation;

Sequence=AAO62549.1; Type=Erroneous initiation; Sequence=DAA01265.1; Type=Erroneous initiation; Sequence=DAA01266.1;

Type=Erroneous initiation; Sequence=DAA01268.1; Type=Erroneous initiation; Sequence=DAA01291.1; Type=Erroneous

initiation; Sequence=DAA01292.1; Type=Erroneous initiation; Sequence=DAA01295.1; Type=Erroneous initiation;

Sequence=DAA01296.1; Type=Erroneous initiation; Sequence=DAA01297.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for KLC1:

3NF1 (3D)

Secondary accessions: A6NF62 Q7RTM2 Q7RTM3 Q7RTM5 Q7RTP9 Q7RTQ5 Q7RTQ6 Q86SF5 Q86TF5 Q86V74 Q86V75

Q86V76 Q86V77 Q86V78 Q86V79 Q96H62

Alternative splicing: 9 isoforms: Q07866-1 Q07866-2 Q07866-3 Q07866-4 Q07866-5 Q07866-6 Q07866-7 Q07866-8

Q07866-9 (Contains a phosphoserine at position 600)

Explore the universe of human proteins at neXtProt for KLC1: NX_Q07866

Post-translational modifications:

Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07866

KLC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001123579.1 NP_005543.2 NP_891553.2

ENSEMBL proteins:

ENSP00000450786 ENSP00000341154 ENSP00000369377 ENSP00000374394 ENSP00000450617

ENSP00000452487 ENSP00000334618 ENSP00000452481 ENSP00000334523 ENSP00000246489

ENSP00000450616 ENSP00000450648 ENSP00000451242 ENSP00000414982 ENSP00000412693

ENSP00000441347 ENSP00000452167 ENSP00000452095 ENSP00000451732 ENSP00000442554

ENSP00000451691

Reactome Protein details: Q07866
Human Recombinant Protein Products:

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	Novus Biologicals KLC1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for KLC1

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0005871	kinesin complex	ISS	--
GO:0005874	microtubule	IEA	--
GO:0030424	axon	--	--

KLC1 for ontologies About GeneDecksing

KLC1 Antibody Products:

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	GenScript Superior Antibodies for KLC1
	Novus Biologicals KLC1 Antibodies
	Abcam antibodies for KLC1
	Uscn Antibodies for KLC1
	ThermoFisher Antibodies for KLC1

Assay Products for KLC1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for KLC1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for KLC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

KLC1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR011990 TPR-like_helical

IPR015792 Kinesin_light_repeat

IPR002151 Kinesin_light

IPR001440 TPR-1

IPR015390 Rabaptin_Rab5-bd_dom

Graphical View of Domain Structure for InterPro Entry Q07866

ProtoNet protein and cluster: Q07866

1 Blocks protein family: IPB002151 Kinesin light chain

UniProtKB/Swiss-Prot: KLC1_HUMAN, Q07866

Similarity: Belongs to the kinesin light chain family

Similarity: Contains 6 TPR repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KLC1_HUMAN, Q07866

Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The

light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity

miRNA Products:		miRTarBase miRNAs that target KLC1: hsa-mir-197 (MIRT004189)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat KLC1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KLC1 (see all 9):
		hsa-miR-3128 hsa-miR-411 hsa-miR-4306 hsa-miR-185 hsa-miR-3126-3p hsa-miR-1286 hsa-miR-3174 hsa-miR-92b*

		SwitchGear 3'UTR luciferase reporter plasmid: KLC1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for KLC1
		Search LifeMap BioReagents cell lines for KLC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLC1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003774	motor activity	TAS	8786116
GO:0003777	microtubule motor activity	IEA	--
GO:0005515	protein binding	IPI	19861499

KLC1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for KLC1:

Decreased cilium length after

Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Klc1):

behavior/neurological

cellular

growth/size

nervous system

other

KLC1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Kinesins

Kinesins

1.00

Kinesins move along microtubules consuming ATP

0.95

MHC class II antigen presentation

MHC class II antigen presentation

1.00

Transport of antigen loaded MHC II molecules to surface

0.59

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

1.00

Selected targets of ESR1

Selected targets of ESR1

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for KLC1

	Selected targets of ESR1
	Cytoplasmic microtubules

1 BioSystems Pathway for KLC1

Arf6 trafficking events

5/8 Reactome Pathways for KLC1 (see all 8)

	Hemostasis
	Adaptive Immune System
	Transport of antigen loaded MHC II molecules to surface
	Kinesins move along microtubules consuming ATP
	Factors involved in megakaryocyte development and platelet production

KLC1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KLC1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/65 Interacting proteins for KLC1 (Q07866^{2, 3} ENSP00000414982⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 65)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAB	P31946²^,³, ENSP00000300161⁴	MINT-50991 I2D: score=4 STRING: ENSP00000300161
LRSAM1	Q6UWE0²^,³	MINT-64684 I2D: score=5
MAPK6	Q16659²^,³	MINT-8261329 I2D: score=2
SFN	P31947²^,³	MINT-3976028 I2D: score=2
SPAG9	O60271³, ENSP00000262013⁴	I2D: score=7 STRING: ENSP00000262013

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007018	microtubule-based movement	TAS	--
GO:0007596	blood coagulation	TAS	--
GO:0008088	axon cargo transport	--	--
GO:0019048	virus-host interaction	IEA	--
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS	--

KLC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KLC1
Search CenterWatch for drugs/clinical trials and news about KLC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KLC1 gene (3 alternative transcripts):

NM_001130107.1 NM_005552.4 NM_182923.3

Unigene Cluster for KLC1:

Kinesin light chain 1

Hs.20107 [show with all ESTs]

Unigene Representative Sequence: AK092888

18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):

ENST00000557172 ENST00000348520(uc001yno.3 uc001yns.3) ENST00000380038(uc010tye.1)

ENST00000555467 ENST00000389744(uc001ynm.1 uc021seh.1) ENST00000557575

ENST00000553286 ENST00000347839 ENST00000555836 ENST00000334553(uc010tyf.2)

ENST00000246489 ENST00000554228(uc001ynr.1 uc010awu.1 uc001ynq.1 uc001ynp.1)

ENST00000557450 ENST00000554280 ENST00000452929 ENST00000445352 ENST00000537046

ENST00000553325

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		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate KLC1 (see all 9):
		hsa-miR-3128 hsa-miR-411 hsa-miR-4306 hsa-miR-185 hsa-miR-3126-3p hsa-miR-1286 hsa-miR-3174 hsa-miR-92b*

		SwitchGear 3'UTR luciferase reporter plasmid: KLC1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLC1

Additional cDNA sequence:

AB451299.1 AB451431.1 AF527736.1 AK024714.1 AK054874.1 AK092888.1 AK294508.1 AL133587.1

AY180163.1 AY180164.2 AY180166.1 AY180167.1 AY180168.1 AY180170.1 AY244715.5 BC008881.2

BC127808.1 L04733.1

24/41 DOTS entries (see all 41):

DT.100866309 DT.80100166 DT.91813991 DT.100866304 DT.80100167 DT.120790828 DT.100866300 DT.436007

DT.97854045 DT.432421 DT.91723587 DT.100030587 DT.100761563 DT.100866295 DT.100866311 DT.120790683

DT.120790759 DT.97854044 DT.120790708 DT.100866294 DT.100866303 DT.100866308 DT.120790820 DT.95107444

24/579 AceView cDNA sequences (see all 579):

BQ963020 AA323263 AW068178 CD557651 CA306755 AW574693 BQ002171 BU859440

BF445730 BQ723461 CR619184 BM970244 AI422004 BU173048 BU680791 BM467738

CD671375 BK001169 BM699985 BE264005 BM828388 BI335731 BM794298 BQ955402

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for KLC1 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	·	15e	^	16a	·
SP1:																															-								-		-		-		-		-		-		-
SP2:																															-								-
SP3:																															-				-				-
SP4:																															-				-		-		-		-		-		-		-		-		-
SP5:																															-						-		-		-		-		-		-		-		-

ExUns:	16b	^	17	^	18a	·	18b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for KLC1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KLC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAACTTCC

About this image

KLC1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Eye

Gut Tube

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KLC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KLC1

SOURCE GeneReport for Unigene cluster: Hs.20107

UniProtKB/Swiss-Prot: KLC1_HUMAN, Q07866

Tissue specificity: Found in a variety of tissues. Mostly abundant in brain and spine

SABiosciences Custom PCR Arrays for KLC1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KLC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KLC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for KLC1 gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	KLC1¹	kinesin light chain 1	84.41(n) 97.19(a)		423484 XM_421389.3 XP_421389.2
lizard (Anolis carolinensis)	Reptilia	-- KLC3⁶	--	80(a) 76(a)	1 ↔ many possible ortholog	1(6057973-6129101) AAWZ02038453(1352-6180)
African clawed frog (Xenopus laevis)	Amphibia	kns2-prov²	kinesin 2	85.11(n)		BC046850.1
zebrafish (Danio rerio)	Actinopterygii	zgc66299²	similar to kinesin 2	80.29(n)		393928 BC055591.1
fruit fly (Drosophila melanogaster)	Insecta	Klc¹	Kinesin light chain	65.33(n) 70.94(a)		39445 NM_079325.3 NP_524049.1
worm (Caenorhabditis elegans)	Secernentea	klc-2¹	Protein KLC-2	62.45(n) 65.66(a)		178942 NM_001028493.2 NP_001023664.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G31240⁶ AT3G27960⁶ (see all 6)	tetratricopeptide repeat-containing protein tetratricopeptide repeat domain-containing protein... (see all 6)	9(a) 9(a) (see all 6)	possible ortholog possible ortholog (see all 6)	2(13317415-13319560) 3(10380380-10383092)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	tetratricopeptide repeat containing protein, putat... tetratricopeptide repeat containing protein, putat... (see all 4)	9(a) 9(a) (see all 4)	possible ortholog possible ortholog (see all 4)	2(35212441-35215229) 3(2756578-2761240)

ENSEMBL Gene Tree for KLC1 (if available)
TreeFam Gene Tree for KLC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for KLC1 gene

KLC2² KLC4² ENSG00000256500² KLC3² NPHP3²

6 SIMAP similar genes for KLC1 using alignment to 17 protein entries: KLC1_HUMAN (see all proteins):

KNS2 APOPT1 KLC4 KLC3 KLC2 NPHP3

KLC1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3212131^1,2	C,F,H	--	84341777(-)	`CTACAA/GTGGCA`	3	--	ds500¹		5		NS EA	588
rs79981537^1,2	F,	--	84341793(+)	`CTGCAC/TTTTTG`	3	--	ds500¹		1		EA	120
rs79120854^1,2	F,	--	84341935(+)	`GAAAAC/TGGCAA`	3	--	ds500¹		1		WA	118
rs3212130^1,2	C,H,	--	84341936(-)	`TTTGCC/TGTTTT`	3	--	ds500¹		5		NS EA	556
rs79320199^1,2	F,	--	84342054(+)	`AAGGTG/CGGGGG`	3	--	ds500¹		1		WA	118
rs3212127^1,2	C,	--	84342205(-)	`tgctcT/Ggagta`	3	--	ds500¹		1		NS	174
rs45625536^1,2	C	--	84342310(-)	`CCCACA/TCAGTG`	3	--	ut3¹		0	--	--	--	--
rs75104408^1,2	F,	--	84342313(+)	`TGAGTG/CGGGGG`	3	--	ut3¹		1		WA	118
rs3212126^1,2	H	--	84342333(-)	`CCACCG/ATACAA`	3	--	ut3¹		5		NS EA	588
rs78863423^1,2	F,	--	84342377(+)	`GGCCAC/TGCCAC`	3	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for KLC1 (104028233 - 104167888 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for KLC1
3 CNVs: 43894 102027 3949

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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KLC1 for disorders           About GeneDecksing

OMIM gene information: 600025    OMIM disorders: --

10 diseases for KLC1:    About MalaCards

medulloblastoma childhood medulloblastoma multiple sclerosis cataract

alzheimer's disease hypertension melanoma pancreatitis

neuronitis ataxia

Human Genome Epidemiology (HuGE) Navigator: KLC1 (14 documents)

Export disorders for KLC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for KLC1 gene, integrated from 9 sources (see all 71):
(articles sorted by number of sources associating them with KLC1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and genetic characterization of the human kinesin light-chain (KLC) gene. (PubMed id 8274221)^{1, 2, 3} Cabeza-Arvelaiz Y.... Lachman L.B. (1993)
Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene. (PubMed id 12839500)^{1, 2, 9} McCart A.E.... Rothnagel J.A. (2003)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. (PubMed id 11106729)^{1, 3} Bowman A.B....Goldstein L.S. (2000)
Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease. (PubMed id 15364413)^{1, 9} Dhaenens C.M....Sablonniere B. (2004)
Evaluation of the roles of the A185C and C406T kinesin light-chain 1 variants in the development of leukoaraiosis. (PubMed id 17977659)^{1, 9} Szolnoki Z....Somogyvari F. (2007)
Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. (PubMed id 12893827)^{1, 9} Matsuda S....D'Adamio L. (2003)
Evaluation of the genetic variants of kinesin motor p rotein in ischemic stroke. (PubMed id 19717019)^{1, 9} Szolnoki Z....Somogyvari F. (2009)
Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension. (PubMed id 19046961)^{1, 9} Szolnoki Z....Somogyvari F. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3831	HGNC: 6387	AceView: KNS2	Ensembl:ENSG00000126214	euGenes: HUgn3831
ECgene: KLC1	H-InvDB: KLC1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for KLC1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KLC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for KLC1 gene:
Search GeneIP for patents involving KLC1

GeneCards and IP:
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kinesin light chain 1

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