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Aliases for KLC1 Gene

Aliases for KLC1 Gene

  • Kinesin Light Chain 1 2 3 5
  • Kinesin 2 60/70kDa 2 3
  • KNS2 3 4
  • KLC 3 4
  • Medulloblastoma Antigen MU-MB-2.50 3
  • Kinesin 2 2
  • KNS2A 3
  • KLC 1 4

External Ids for KLC1 Gene

Previous HGNC Symbols for KLC1 Gene

  • KNS2

Previous GeneCards Identifiers for KLC1 Gene

  • GC14P103167
  • GC14P104030
  • GC14P104095
  • GC14P104028
  • GC14P103564
  • GC14P103565

Summaries for KLC1 Gene

Entrez Gene Summary for KLC1 Gene

  • Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLC1 Gene

KLC1 (Kinesin Light Chain 1) is a Protein Coding gene. Diseases associated with KLC1 include medulloblastoma. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include microtubule motor activity and tubulin binding. An important paralog of this gene is KLC4.

UniProtKB/Swiss-Prot for KLC1 Gene

  • Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Gene Wiki entry for KLC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLC1 Gene

Genomics for KLC1 Gene

Regulatory Elements for KLC1 Gene

Promoters for KLC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KLC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KLC1 Gene

Chromosome:
14
Start:
103,561,896 bp from pter
End:
103,714,249 bp from pter
Size:
152,354 bases
Orientation:
Plus strand

Genomic View for KLC1 Gene

Genes around KLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLC1 Gene

Proteins for KLC1 Gene

  • Protein details for KLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07866-KLC1_HUMAN
    Recommended name:
    Kinesin light chain 1
    Protein Accession:
    Q07866
    Secondary Accessions:
    • A6NF62
    • F8VTM4
    • Q7RTM2
    • Q7RTM3
    • Q7RTM5
    • Q7RTP9
    • Q7RTQ3
    • Q7RTQ5
    • Q7RTQ6
    • Q86SF5
    • Q86TF5
    • Q86V74
    • Q86V75
    • Q86V76
    • Q86V77
    • Q86V78
    • Q86V79
    • Q96H62

    Protein attributes for KLC1 Gene

    Size:
    573 amino acids
    Molecular mass:
    65310 Da
    Quaternary structure:
    • Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9. Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections. Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with adenovirus hexon-interlacing protein; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell.
    SequenceCaution:
    • Sequence=AAA16576.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF72543.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO62549.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DAA01265.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01266.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01268.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01289.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01291.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01292.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01295.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01296.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KLC1 Gene

    Alternative splice isoforms for KLC1 Gene

neXtProt entry for KLC1 Gene

Proteomics data for KLC1 Gene at MOPED

Post-translational modifications for KLC1 Gene

  • Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KLC1 (KLC1)

No data available for DME Specific Peptides for KLC1 Gene

Domains & Families for KLC1 Gene

Gene Families for KLC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q07866

UniProtKB/Swiss-Prot:

KLC1_HUMAN :
  • Belongs to the kinesin light chain family.
  • Contains 6 TPR repeats.
Family:
  • Belongs to the kinesin light chain family.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with KLC1: view

Function for KLC1 Gene

Molecular function for KLC1 Gene

UniProtKB/Swiss-Prot Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
genes like me logo Genes that share phenotypes with KLC1: view

Animal Models for KLC1 Gene

MGI Knock Outs for KLC1:

Animal Model Products

miRNA for KLC1 Gene

miRTarBase miRNAs that target KLC1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KLC1 Gene

Localization for KLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLC1 Gene

Cell projection, growth cone. Cytoplasmic vesicle. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KLC1 Gene COMPARTMENTS Subcellular localization image for KLC1 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for KLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with KLC1: view

Pathways & Interactions for KLC1 Gene

genes like me logo Genes that share pathways with KLC1: view

Pathways by source for KLC1 Gene

1 BioSystems pathway for KLC1 Gene
1 KEGG pathway for KLC1 Gene

SIGNOR curated interactions for KLC1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for KLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007596 blood coagulation TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with KLC1: view

Drugs & Compounds for KLC1 Gene

(3) Drugs for KLC1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1684
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1044
leucovorin Approved Pharma 952
genes like me logo Genes that share compounds with KLC1: view

Transcripts for KLC1 Gene

Unigene Clusters for KLC1 Gene

Kinesin light chain 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ^ 16a ·
SP1: - - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - -
SP10: - - - - - - - -
SP11: - -
SP12:
SP13: -

ExUns: 16b ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for KLC1 Gene

GeneLoc Exon Structure for
KLC1
ECgene alternative splicing isoforms for
KLC1

Expression for KLC1 Gene

mRNA expression in normal human tissues for KLC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KLC1 Gene

This gene is overexpressed in Fetal Brain (13.3), Peripheral blood mononuclear cells (8.2), and Spinal cord (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLC1 Gene



SOURCE GeneReport for Unigene cluster for KLC1 Gene Hs.20107

mRNA Expression by UniProt/SwissProt for KLC1 Gene

Q07866-KLC1_HUMAN
Tissue specificity: Found in a variety of tissues. Mostly abundant in brain and spine.
genes like me logo Genes that share expression patterns with KLC1: view

Protein tissue co-expression partners for KLC1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KLC1 Gene

Orthologs for KLC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KLC1 35
  • 90.47 (n)
  • 97.52 (a)
KLC1 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia KLC1 35
  • 92.12 (n)
  • 98.35 (a)
-- 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Klc1 35
  • 86.8 (n)
  • 97.24 (a)
Klc1 16
Klc1 36
  • 96 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KLC1 35
  • 98.79 (n)
  • 98.84 (a)
rat
(Rattus norvegicus)
Mammalia Klc1 35
  • 86.73 (n)
  • 98.18 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KLC1 35
  • 84.41 (n)
  • 97.19 (a)
-- 36
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia klc1 35
  • 82.46 (n)
  • 97.48 (a)
Str.3663 35
African clawed frog
(Xenopus laevis)
Amphibia kns2-prov 35
zebrafish
(Danio rerio)
Actinopterygii klc1a 35
  • 75.5 (n)
  • 85.9 (a)
zgc66299 35
klc1a 36
  • 86 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010258 35
  • 63.04 (n)
  • 71.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klc 35
  • 65.92 (n)
  • 72.15 (a)
Klc 36
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klc-2 35
  • 61.98 (n)
  • 65.06 (a)
klc-1 36
  • 43 (a)
ManyToMany
klc-2 36
  • 62 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.705 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for KLC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLC1 Gene

ENSEMBL:
Gene Tree for KLC1 (if available)
TreeFam:
Gene Tree for KLC1 (if available)

Paralogs for KLC1 Gene

Paralogs for KLC1 Gene

genes like me logo Genes that share paralogs with KLC1: view

Variants for KLC1 Gene

Sequence variations from dbSNP and Humsavar for KLC1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1606 -- 103,694,944(-) GCTGG(C/T)GACTA intron-variant
rs6593 -- 103,696,945(-) CTTCC(C/T)GTCCC intron-variant
rs709400 -- 103,683,138(-) GATTA(C/T)CATTA intron-variant
rs8702 -- 103,686,015(-) TTGCT(C/G)TAAGG intron-variant, utr-variant-3-prime
rs11837 -- 103,696,988(-) ATGCT(A/G)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLC1 Gene

Variant ID Type Subtype PubMed ID
nsv832883 CNV Loss 17160897
nsv902300 CNV Loss 21882294
nsv902308 CNV Loss 21882294
esv2543794 CNV Deletion 19546169
esv2001728 CNV Deletion 18987734
esv2663768 CNV Deletion 23128226
dgv1995n71 CNV Loss 21882294
dgv658e1 CNV Complex 17122850
nsv527425 CNV Loss 19592680
nsv470673 CNV Loss 18288195
nsv902313 CNV Loss 21882294
nsv902314 CNV Loss 21882294
nsv902315 CNV Loss 21882294
esv2749175 CNV Deletion 23290073

Variation tolerance for KLC1 Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KLC1 Gene

HapMap Linkage Disequilibrium report
KLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLC1 Gene

Disorders for KLC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KLC1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
medulloblastoma
  • medulloblastoma, desmoplastic
- elite association - COSMIC cancer census association via MalaCards
Search KLC1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KLC1

Genetic Association Database (GAD)
KLC1
Human Genome Epidemiology (HuGE) Navigator
KLC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KLC1
genes like me logo Genes that share disorders with KLC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KLC1 Gene

Publications for KLC1 Gene

  1. Cloning and genetic characterization of the human kinesin light-chain (KLC) gene. (PMID: 8274221) Cabeza-Arvelaiz Y. … Lachman L.B. (DNA Cell Biol. 1993) 2 3 4 67
  2. Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension. (PMID: 19046961) Szolnoki Z. … Somogyvari F. (Clin. Biochem. 2009) 3 23
  3. Evaluation of the genetic variants of kinesin motor protein in ischemic stroke. (PMID: 19717019) Szolnoki Z. … Somogyvari F. (J Stroke Cerebrovasc Dis 2009) 3 23
  4. A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: gene-environmental interactions behind vascular white matter demyelinization. (PMID: 17917076) Szolnoki Z. … Somogyvari F. (J. Mol. Neurosci. 2007) 3 23
  5. Evaluation of the roles of the A185C and C406T kinesin light-chain 1 variants in the development of leukoaraiosis. (PMID: 17977659) Szolnoki Z. … Somogyvari F. (Neurosci. Lett. 2007) 3 23

Products for KLC1 Gene

Sources for KLC1 Gene

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