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Aliases for KLC1 Gene

Aliases for KLC1 Gene

  • Kinesin Light Chain 1 2 3
  • KNS2 3 4 6
  • Kinesin 2 60/70kDa 2 3
  • KNS2A 3 6
  • KLC 3 4
  • Medulloblastoma Antigen MU-MB-2.50 3
  • Kinesin 2 2
  • KLC 1 4

External Ids for KLC1 Gene

Previous HGNC Symbols for KLC1 Gene

  • KNS2

Previous GeneCards Identifiers for KLC1 Gene

  • GC14P103167
  • GC14P104030
  • GC14P104095
  • GC14P104028

Summaries for KLC1 Gene

Entrez Gene Summary for KLC1 Gene

  • Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for KLC1 Gene

KLC1 (Kinesin Light Chain 1) is a Protein Coding gene. Diseases associated with KLC1 include medulloblastoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Hemostasis. GO annotations related to this gene include microtubule motor activity and tubulin binding. An important paralog of this gene is KLC4.

UniProtKB/Swiss-Prot for KLC1 Gene

  • Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity

Gene Wiki entry for KLC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLC1 Gene

Genomics for KLC1 Gene

Regulatory Elements for KLC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KLC1 Gene

Start:
103,561,896 bp from pter
End:
103,714,249 bp from pter
Size:
152,354 bases
Orientation:
Plus strand

Genomic View for KLC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KLC1 Gene

Proteins for KLC1 Gene

  • Protein details for KLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07866-KLC1_HUMAN
    Recommended name:
    Kinesin light chain 1
    Protein Accession:
    Q07866
    Secondary Accessions:
    • A6NF62
    • F8VTM4
    • Q7RTM2
    • Q7RTM3
    • Q7RTM5
    • Q7RTP9
    • Q7RTQ3
    • Q7RTQ5
    • Q7RTQ6
    • Q86SF5
    • Q86TF5
    • Q86V74
    • Q86V75
    • Q86V76
    • Q86V77
    • Q86V78
    • Q86V79
    • Q96H62

    Protein attributes for KLC1 Gene

    Size:
    573 amino acids
    Molecular mass:
    65310 Da
    Quaternary structure:
    • Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9. Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections. Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with adenovirus hexon-interlacing protein; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell.
    SequenceCaution:
    • Sequence=AAA16576.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF72543.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO62549.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DAA01265.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01266.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01268.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01289.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01291.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01292.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01295.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01296.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=DAA01297.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KLC1 Gene

    Alternative splice isoforms for KLC1 Gene

neXtProt entry for KLC1 Gene

Proteomics data for KLC1 Gene at MOPED

Post-translational modifications for KLC1 Gene

  • Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631.
  • Ubiquitination at Lys309
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KLC1 Gene

Domains for KLC1 Gene

Gene Families for KLC1 Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Suggested Antigen Peptide Sequences for KLC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q07866

UniProtKB/Swiss-Prot:

KLC1_HUMAN :
  • Q07866
Family:
  • Belongs to the kinesin light chain family.
Similarity:
  • Contains 6 TPR repeats.
genes like me logo Genes that share domains with KLC1: view

Function for KLC1 Gene

Molecular function for KLC1 Gene

UniProtKB/Swiss-Prot Function: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity

Gene Ontology (GO) - Molecular Function for KLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity TAS 8786116
GO:0003777 microtubule motor activity IEA --
GO:0005515 protein binding IPI 11238452
GO:0015631 tubulin binding --
genes like me logo Genes that share ontologies with KLC1: view
genes like me logo Genes that share phenotypes with KLC1: view

Animal Model Products

CRISPR Products

miRNA for KLC1 Gene

miRTarBase miRNAs that target KLC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KLC1 Gene

Localization for KLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KLC1 Gene

Cell projection, growth cone. Cytoplasmic vesicle. Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for KLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005871 kinesin complex ISS --
GO:0005874 microtubule IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with KLC1: view

No data available for Subcellular locations from COMPARTMENTS for KLC1 Gene

Pathways for KLC1 Gene

genes like me logo Genes that share pathways with KLC1: view

Pathways by source for KLC1 Gene

Gene Ontology (GO) - Biological Process for KLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport --
GO:0007018 microtubule-based movement TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007596 blood coagulation TAS --
GO:0008088 axon cargo transport --
genes like me logo Genes that share ontologies with KLC1: view

Compounds for KLC1 Gene

(5) PharmGKB related drug/compound annotations for KLC1 Gene

Drug/compound Annotation
cisplatin CA
docetaxel CA
fluorouracil CA
irinotecan CA
leucovorin CA
genes like me logo Genes that share compounds with KLC1: view

Transcripts for KLC1 Gene

Unigene Clusters for KLC1 Gene

Kinesin light chain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KLC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KLC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ^ 16a ·
SP1: - - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: -
SP9: - - -
SP10: - - - - - - - -
SP11: - -
SP12:
SP13: -

ExUns: 16b ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for KLC1 Gene

GeneLoc Exon Structure for
KLC1
ECgene alternative splicing isoforms for
KLC1

Expression for KLC1 Gene

mRNA expression in normal human tissues for KLC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KLC1 Gene

SOURCE GeneReport for Unigene cluster for KLC1 Gene Hs.20107

mRNA Expression by UniProt/SwissProt for KLC1 Gene

Q07866-KLC1_HUMAN
Tissue specificity: Found in a variety of tissues. Mostly abundant in brain and spine.
genes like me logo Genes that share expressions with KLC1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for KLC1 Gene

Orthologs for KLC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KLC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KLC1 35
  • 98.79 (n)
  • 98.84 (a)
cow
(Bos Taurus)
Mammalia KLC1 35
  • 90.47 (n)
  • 97.52 (a)
KLC1 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
KLC1 35
  • 92.12 (n)
  • 98.35 (a)
mouse
(Mus musculus)
Mammalia Klc1 35
  • 86.8 (n)
  • 97.24 (a)
Klc1 16
Klc1 36
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Klc1 35
  • 86.73 (n)
  • 98.18 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 95 (a)
OneToMany
KLC1 35
  • 84.41 (n)
  • 97.19 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia kns2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia klc1 35
  • 82.46 (n)
  • 97.48 (a)
Str.3663 35
zebrafish
(Danio rerio)
Actinopterygii klc1a 35
  • 75.5 (n)
  • 85.9 (a)
klc1a 36
  • 86 (a)
OneToMany
zgc66299 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010258 35
  • 63.04 (n)
  • 71.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Klc 35
  • 65.92 (n)
  • 72.15 (a)
Klc 36
  • 70 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea klc-1 36
  • 43 (a)
ManyToMany
klc-2 35
  • 61.98 (n)
  • 65.06 (a)
klc-2 36
  • 62 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.705 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToMany
Species with no ortholog for KLC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KLC1 Gene

ENSEMBL:
Gene Tree for KLC1 (if available)
TreeFam:
Gene Tree for KLC1 (if available)

Paralogs for KLC1 Gene

Paralogs for KLC1 Gene

genes like me logo Genes that share paralogs with KLC1: view

Variants for KLC1 Gene

Sequence variations from dbSNP and Humsavar for KLC1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1606 -- 103,694,944(-) GCTGG(C/T)GACTA intron-variant
rs6593 -- 103,696,945(-) CTTCC(C/T)GTCCC intron-variant
rs8702 -- 103,686,015(-) TTGCT(C/G)TAAGG intron-variant, utr-variant-3-prime
rs11837 -- 103,696,988(-) ATGCT(A/G)GCTCA intron-variant
rs709400 -- 103,683,138(-) GATTA(C/T)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KLC1 Gene

Variant ID Type Subtype PubMed ID
nsv832883 CNV Loss 17160897
nsv902300 CNV Loss 21882294
nsv902308 CNV Loss 21882294
esv2543794 CNV Deletion 19546169
esv2001728 CNV Deletion 18987734
esv2663768 CNV Deletion 23128226
dgv1995n71 CNV Loss 21882294
dgv658e1 CNV Complex 17122850
nsv527425 CNV Loss 19592680
nsv470673 CNV Loss 18288195
nsv902313 CNV Loss 21882294
nsv902314 CNV Loss 21882294
nsv902315 CNV Loss 21882294
esv2749175 CNV Deletion 23290073

Relevant External Links for KLC1 Gene

HapMap Linkage Disequilibrium report
KLC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLC1 Gene

Disorders for KLC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KLC1 Gene including...

Search for KLC1 Gene in MalaCards »

Relevant External Links for KLC1

Genetic Association Database (GAD)
KLC1
Human Genome Epidemiology (HuGE) Navigator
KLC1
genes like me logo Genes that share disorders with KLC1: view

No data available for UniProtKB/Swiss-Prot for KLC1 Gene

Publications for KLC1 Gene

  1. Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene. (PMID: 12839500) McCart A.E. … Rothnagel J.A. (Traffic 2003) 3 4 23
  2. A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: gene-environmental interactions behind vascular white matter demyelinization. (PMID: 17917076) Szolnoki Z. … Somogyvari F. (J. Mol. Neurosci. 2007) 3 23 48
  3. Evaluation of the roles of the A185C and C406T kinesin light-chain 1 variants in the development of leukoaraiosis. (PMID: 17977659) Szolnoki Z. … Somogyvari F. (Neurosci. Lett. 2007) 3 23 48
  4. A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant. (PMID: 17999208) Szolnoki Z. … Somogyvari F. (Neuromolecular Med. 2007) 3 23 48
  5. Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension. (PMID: 19046961) Szolnoki Z. … Somogyvari F. (Clin. Biochem. 2009) 3 23 48

Products for KLC1 Gene

  • Addgene plasmids for KLC1

Sources for KLC1 Gene

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